Gene RNGTT-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily RNGTT
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP017_AA protein Get Run
MbreP017_AA_18-176 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0038934 (Phosphotyrosine protein) phosphatases II 10-171 5.8e-40 132.4 In-house 2-164 (194) alignment 
Range on Protein: 10-171
Range on HMM: 2-164/194.0
VPERWLPCPRFGKLIDageGHFWPFKTPLGRRYMDDVPIERAWTPEMAKARYKD---ELRFVINLTKTTRYYEAEEFG-NDVHTQQIQCAGHGERPTPEQ
.|.||| ..|.|..|    |.| .||.||  .. . .. .  ..||.    .|.   .|. ||.||.|.|||..|||  ....  .... ..|. |. |.
lPdrwlkyervgdiit...grfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPslei

VKVFIHVCKTFWQKQPGCTIGVHCTHGFNRTGFMICCYLIEEMDCAVEDALQLFAKSRDPGIYKYG
.. |......| ...||....|||..|..|||.....|||. ... .|.|..||.  | ..|....
llrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqd
subfamily_DSP11_pd Subfamily DSP11 10-164 3.2e-34 112.4 In-house 1-158 (178) alignment 
Range on Protein: 10-164
Range on HMM: 1-158/178.0
VPERWLPCPRFGKLIDAgeGHFWPFKTPLGRRYMDDVPIERAWTPEMAKARY---KDELRFVINLTKTTRYYEAEEFGND-VHTQQIQCAGHGErPTPEQ
||.||      |. |.     | .||||| ... ..|. |. .||.    .    . .| .||.||.|.|||. .|. .  |. ....|.||   |. | 
vPdrwkkykpvgdkieg..trfiafktPlkesfdkkveeekrftpkdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhev.pkeel

VKVFIHVCKTFW--QKQPGCTIGVHCTHGFNRTGFMICCYLIEEMDCAVEDALQLFAKSRD
|| |... | |   .|. .  |||||||| ||||..|| |||. ..   |||.. | . | 
vkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearG
subfamily_RNGTT_pd Subfamily RNGTT 11-169 9.9e-73 237.9 In-house 1-160 (189) alignment 
Range on Protein: 11-169
Range on HMM: 1-160/189.0
PERWLPCPRFGKLIdagEGHFWPFKTPLGRRYMDDVPIERAWTPEMAKARYK---DELRFVINLTKTTRYYEAEEFGN-DVHTQQIQCAGHGERPTPEQV
||||| ||| ||||   ...|.||||||..||.||...|....|.|.....|   ..|..||.||.|.|||..||. . .......||||.||.|..|||
PerWlnCPrkgkli...aekflpfktplskrydddlaeenrfepsmllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqv

KVFIHVCKTFWQKQPGCTIGVHCTHGFNRTGFMICCYLIEEMDCAVEDALQLFAKSRDPGIYK
| ||.....|..|.| ..||||||||||||||.|..||.|..|..||.|..||||.|.|||||
kefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiyk
PTEN_1 55-168 3.5e-18 61.1 In-house 58-176 (196) alignment 
Range on Protein: 55-168
Range on HMM: 58-176/196.0
EMAKARYKDELRFVINLTKTTR-----YYEAEEFGNDVHTQQIQCAGHGErPTPEQVKVFIHVCKTFWQKQP-GCTIGVHCTHGFNRTGFMICCYLIEEM
.. . ...| ...|.||.         |.. |.| ..|   ..    ||  |. ...  .. ...  ....| | .. |||..| .|.|.....||.. .
adldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhga.pslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykg

DCAVEDALQLFAKSRDPGIY
   ...||.|... | ||  
kltadeAlelvrekRppgap
subfamily_PTEN_pd Subfamily PTEN 58-163 3.2e-13 45.1 In-house 55-156 (184) alignment 
Range on Protein: 58-163
Range on HMM: 55-156/184.0
KARYKDELRfVINLTkTTRYYEAEEFGNDVHTQQIQcaGHgERPTPEQVKVFIHVCKTFWQKQPGCTIGVHCTHGFNRTGFMICCYLIEEMDCAVE-DAL
. ..||. . ..||. . |.|....| . |.. ...   | . |. | .. ...  ... ....   . |||  |  ||| .|..||.... .  . .||
ekkhkdhyk.iynlr.serkydskkfdgrvavypfd..Dh.nppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeeal

QLFAKSR
.|||. |
elfaeaR
subfamily_VSP_pd Subfamily VSP 59-163 4.5e-11 37.1 In-house 70-170 (212) alignment 
Range on Protein: 59-163
Range on HMM: 70-170/212.0
ARYKDELRfVINLTkTTRYYEAEEFGNDVHtqQIQCAGHgERPTPEQVKVFIHVCKTFWQKQPGCTIGVHCTHGFNRTGFMICCYLIEEMD-CAVEDALQ
 ...|. . |.||  . | |. . | | |.  .|.   | . |. |.. || .  | . .|..   . .||  | .||| ..|..|..       ...|.
tkhrdhyk.vvnlc.seraydekyfnnrvk..riliddh.nvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesld

LFAKSR
 |.. |
yfgerr
0041856 (Phosphotyrosine protein) phosphatases II 60-168 1.8e-19 65.4 In-house 54-155 (182) alignment 
Range on Protein: 60-168
Range on HMM: 54-155/182.0
RYKDELRFVINLTkTTRYYEAEEFGNDVHTQQIQCAGHGERPtPEQVKVFIHVCKTfwqkqPGCTIGVHCTHGFNRTGFMICCYLIEEMDCAVEDALQLF
 ..   . ..|||   .|.  ..  . .. ..... .||  . ....  ||. ..      .|... |||..| .|||.....||...... .|.|..|.
lkelgittivnlt.eelywpellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklv

AKSRDPGIY
 . |  .. 
rsrRpgmvi
0049772 (Phosphotyrosine protein) phosphatases II 60-164 3.1e-18 62.0 In-house 161-255 (314) alignment 
Range on Protein: 60-164
Range on HMM: 161-255/314.0
RYKDELRfvinltktTRYYEAEEFGND-VHTQQIQCAGhGERPTPEQVKVFIHVCKTFwqkQPGCTIGVHCTHGFNRTG-FMICCYLIEEMDCAVEDALQ
.. ..|.        ...|..| | .  ..  .| . . |. |..|... |.......   ..|  . |||..| .||| |....||.  ... .|.||.
adlellk........eelydpelferlgikylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleeale

LFAKSRD
 . . | 
dvrlkRp
0045450 (Phosphotyrosine protein) phosphatases II 61-166 6.8e-17 57.6 In-house 61-286 (307) alignment 
Range on Protein: 61-166
Range on HMM: 61-286/307.0
YKD-------------------------------------------------------------------ELRFVINLTKTT--------RYYEAE----
|||                                                                     . ...||...        .|.  |    
ykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeel

-----------------------------EFGNDVHTQQIQC---AGHGERPTPEQVKVFIHVCKTFWQKQ-PGCTIGVHCTHGFNRTGFMICCYLIEEM
                             . |.  . .....    .||  |..|..  ||. .... ..  .|. . |||..| .||| .|..||. ..
tygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrq

D--------CAVEDALQLFAKSRDPG
         . ...|..|. . |  .
lekegtlldvdlleavkllreqRpga
0051082 (Phosphotyrosine protein) phosphatases II 61-165 4.4e-16 54.3 In-house 30-134 (151) alignment 
Range on Protein: 61-165
Range on HMM: 30-134/151.0
YKDELRFVINLTKTT-RYYEAEEFGN-DVHTQQIQCAGHGERPTPEQVKVFIHVCKTFWQkQPGCTIGVHCTHGFNRTGFMICCYLIEeMDCAVEDALQL
..  .. ..||.... |.|..| . . ...  .|.. .. . ..|.  . .... . . . ...  . |||..| .|||.....||.  ... .|.||. 
kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylml.lgvsleealee

FAKSRDP
. ..|  
yrlkrpg
0048567 (Phosphotyrosine protein) phosphatases II 61-176 5.1e-10 33.9 In-house 11-130 (157) alignment 
Range on Protein: 61-176
Range on HMM: 11-130/157.0
YKDELRFVINLTKTTRYYEAEEFG-ND--VHTQQIQCAGhgeRPTPEQVKVFIHVCKTFWQ--KQPGCTIGVHCTHGF---NRTGFMICCYLIEEMDCAV
..| | |..   .....|.|  |  .|  |.   ..  |    ..  ..  ||.. . |..  .  |..| |||..|     ||...|.||||  ..   
ipdrlyfallprlpkslynalyFsiddglvyedfffdfG...PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftp

EDALQLFaKSRDPGIYKYGKATFF
|.|.... .  .||.. . .|...
eeaiapl.rivrpgsvpfrdasyl
0048076 (Phosphotyrosine protein) phosphatases II 62-170 7.2e-18 60.1 In-house 27-129 (145) alignment 
Range on Protein: 62-170
Range on HMM: 27-129/145.0
KDELRFVINLTKTTRYYEaeefGNDVHTQQIQCAGHGERPTPEQVKVFIHVCKTFWQKqpGCTIGVHCTHGFNRTGFMICCYLIEEMDCAVEDALQLFAK
.  .. |.||| .....|     .... ... . .||. . .|..  |.. .... ..  |. . |||..| .|||.....||. .... .|.||.|. .
dlgittvlnltselelle....rlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmlllgvsleealelvrs

SRDPGIYKY
 |  ...  
qrpgavpnp
0044763 (Phosphotyrosine protein) phosphatases II 62-170 8.8e-18 60.0 In-house 46-157 (178) alignment 
Range on Protein: 62-170
Range on HMM: 46-157/178.0
KDELRFVINLTKTTRYYEAEEFGND-----VHTQQIQCAGHGERPTPEQVKVFIHVCKTFWQkQPGCTIGVHCTHGFNRTGFMICCYLIEEMDCAVEDAL
.  .. ..|||......  ...  .     .. ..| . .||. . .|..  |.. .... . ..|... |||..|..|.| ....||. .... .|.|.
elgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkklglsleeai

QLFAKSRDpGIYKY
.|. . |  ...  
elvrerRp.ivpnp
0046846 (Phosphotyrosine protein) phosphatases II 62-164 1.4e-14 49.7 In-house 45-152 (176) alignment 
Range on Protein: 62-164
Range on HMM: 45-152/176.0
KDELRFVINLTKTT-------RYYEAEEFGNDVHTQQIQCAGHGERPTpEQVKVFIHVCKTFWQKQpgCTIGVHCTHGFNRTGFMICCYLIEE-MDCAVE
.   . |.|||. .        .|  |. ..... ...    ||  .  |..  ..  .... ..    .. ||| .| .||| ....||.|  ..  ||
elgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsve

DALQLFAKSRD
.||.|. . | 
ealalvreqRp
subfamily_CDC14_pd Subfamily CDC14 62-156 2.9e-09 31.2 In-house 210-297 (328) alignment 
Range on Protein: 62-156
Range on HMM: 210-297/328.0
KDELRFVINLTKTtrYYEAEEFGNDVHTQQIQCAGHGERPTPEQVKVFIHVCKTFwqkqpGCTIGVHCTHGFNRTGFMICCYLIEEMDCAVEDAL
| ... |. | |    |.|..| .     . .    |  |. . || |......        .| |||  |. ||| .| |||...   . ..|.
knnvttvvrLnkk..lYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacylmkhyrftaaeai
0048179 (Phosphotyrosine protein) phosphatases II 63-169 5.3e-18 60.6 In-house 28-130 (144) alignment 
Range on Protein: 63-169
Range on HMM: 28-130/144.0
DELRFVINLTKTtrYYEAEEFGNDVHTQQIQCAGHGERPTPEQVKVFIHVCKTFWQkqPGCTIGVHCTHGFNRTGFMICCYLIEEMDCAVEDALQLFAKS
  .. ||||| .  |. ...  . .. ... . .||  . .|..  |.. .... .  .|. . |||..|..|||.....||. .... .|.||.|. . 
lgittvinltee..yepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmkklglsleealalvrsr

RDPGIYK
|  ... 
rpgavpn
subfamily_DSP23_pd Subfamily DSP23 63-173 7e-13 43.5 In-house 30-135 (148) alignment 
Range on Protein: 63-173
Range on HMM: 30-135/148.0
DELRFVINLTKTTRYYeaEEFGNDVHTQQIQCAGHgERPTPEQVKVFIHVCKTFWQKqpGCTIGVHCTHGFNRTGFMICCYLIEEMDCAVEDALQLFAKS
  .|... ||. .|     |   ..  ....   .   |..|||. |..| .   .|  . ...|||  |. ||| |. |||. | . |  .|.    . 
lgvrylvslteegrph..veatpnltlvrlriddy.hppaleqvvefvrvveeaeek..neavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrl

RDPGIYKYGKA
|   .  . . 
rpgsvetveqe
0040438 (Phosphotyrosine protein) phosphatases II 64-169 5.1e-17 57.6 In-house 110-261 (317) alignment 
Range on Protein: 64-169
Range on HMM: 110-261/317.0
ELRFVINLTKTTRY--------Y---------------EAEEFGNDVHTQQIQC-------------------AGHGERPTPEQVKVFIHVCKTFWQkQP
 .. ...||... .        .                 ||  ....  ....                     ||  |.|...  |.. .... . .|
gvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dp

GCTIGVHCTHGFNRTGFMICCYLI-----EEMDCAVEDALQLFAKSRDPGIYK
|. . |||..| .|||..|..||.     .|... ||.|.. . . |  ... 
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqt
0037934 (Phosphotyrosine protein) phosphatases II 64-167 9.9e-17 56.8 In-house 72-225 (243) alignment 
Range on Protein: 64-167
Range on HMM: 72-225/243.0
ELRFVINLTKTT----------------------------------------RYYE-AEEFGNDVHTQQIQCAGHGERPTPEQVKVFIHVCKTFWQK---
  . ...||...                                        ....  ... ...| ...   .||  ..||..  |.. ...| ..   
gitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieells

----QPGCTIGVHCTHGFNRTGFMICCYLIEEM-DCAVEDALQLFAKSRDP-GI
     .| .. |||..| .||| .|..||. .. .. .|.|..|. . |   ..
llaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkav
0040439 (Phosphotyrosine protein) phosphatases II 64-166 1.6e-16 56.2 In-house 78-228 (249) alignment 
Range on Protein: 64-166
Range on HMM: 78-228/249.0
ELRFVINLTKTTRY---------------------------------------YEAEEFGNDVHTQQIQC---AGHGERPTPEQVKVFIHVCKTFWQKQ-
  . ...||.....                                        .  ..|.... ..||.     ||  |..|..  ||. .... ..  
gitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelp

PGCTIGVHCTHGFNRTGFMICCYLI-----EEMDCAVEDALQLFAKSRDPG
.|. . |||..| .|||..|..||.     .| .  .|.|..|. . |  .
kggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpga
0042113 (Phosphotyrosine protein) phosphatases II 64-166 1.7e-15 52.6 In-house 76-224 (245) alignment 
Range on Protein: 64-166
Range on HMM: 76-224/245.0
ELRFVINLTKTTRYY------------------------------------------EAEEFGNDVHTQQIQCAGHGERPTPEQVKVFIHVCKTFWQKQP
 .. ...||... .                                              |  ...| ... . .||. ...|..  |.. .... .. .
gittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaeds

GCTIGVHCTHGFNRTGFMICCYLI-----EEMDCAVEDALQLFAKSRdPG
. .. |||..| .||| .|..||.     .|..  .|.|.. . . | ||
ngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqR.pg
DSPc Dual specificity phosphatase, catalytic domain 64-167 2.6e-13 45.0 Pfam-A 18-117 (133) alignment 
Range on Protein: 64-167
Range on HMM: 18-117/133.0
ELRFVINLTKTTRYYeaeEFGNDVHTQQIQCAGHGerPTPEQVKVFIHVCKTFWQ--KQPGCTIGVHCTHGFNRTGFMICCYLIEEMDCAVEDALQLFAK
.. .|||.||...      . .. . .....  .    | ...  ..  ...| .  .| |... |||..| .|.. .|..||.... . ...|.... .
gitlvinvtkevpnn...naikkseieylripved..etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvke

SRdPGI
 | . |
rr.ski
DSPc Dual specificity phosphatase, catalytic domain 64-167 2.6e-13 45.0 In-house 18-117 (133) alignment 
Range on Protein: 64-167
Range on HMM: 18-117/133.0
ELRFVINLTKTTRYYeaeEFGNDVHTQQIQCAGHGerPTPEQVKVFIHVCKTFWQ--KQPGCTIGVHCTHGFNRTGFMICCYLIEEMDCAVEDALQLFAK
.. .|||.||...      . .. . .....  .    | ...  ..  ...| .  .| |... |||..| .|.. .|..||.... . ...|.... .
gitlvinvtkevpnn...naikkseieylripved..etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvke

SRdPGI
 | . |
rr.ski
0045098 (Phosphotyrosine protein) phosphatases II 65-166 6.3e-13 44.2 In-house 89-252 (278) alignment 
Range on Protein: 65-166
Range on HMM: 89-252/278.0
LRFVINLTKTTRY-------------------------------------------YEAEEFGNDVHTQQIQCAGHGERPTPEQV--KVFIHVCKTFWQK
 . ...||. . .                                           .  .| .   . ..... .  .  .|..   | |.....   . 
itvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirea

Q---------------PGCTIGVHCTHGFNRTGFMICCYLIEEM---DCAVEDALQLFAKSRdPG
.               .|... ||| .| .||| ....||. |.    . ...|.. . . | ||
lkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqR.pg
0051429 (Phosphotyrosine protein) phosphatases II 65-166 7.8e-10 34.4 In-house 46-207 (272) alignment 
Range on Protein: 65-166
Range on HMM: 46-207/272.0
LRFVINLTKTT--RYYEAEEFGNDVHTQQIQCAGHGERPTP---------------------------------------------------EQVKVFIH
.. ...|....   ..  . .  ...  .. . .... .                                                     |... ...
iktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallelle

VCKTfwqkqpGCTIGVHCTHGFNRTGFMICCYLIEeMDCA--------------VEDALQLFAKSRDPG
.. .      |  . |||..| .|||......|.  ..                .|.|..   . |   
llld......ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpga
0043147 (Phosphotyrosine protein) phosphatases II 66-168 1e-19 66.4 In-house 46-145 (172) alignment 
Range on Protein: 66-168
Range on HMM: 46-145/172.0
RFVINLTkTTRYYEAEEFGNDVHTQQIQCAGHGERpTPEQVKVFIHVCKTFWQKQPGCTIGVHCTHGFNRTGFMICCYLIEeMDCAVEDALQLFAKSRDP
. ..||| .  |.   .. .... . . .  ||   ..|..  |.. .... ...||... |||..|..|||.....||.. ... .|.|..|. . |  
thivnlt.ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpg

GIY
...
avq
0039614 (Phosphotyrosine protein) phosphatases II 66-165 1.4e-13 46.4 In-house 127-269 (297) alignment 
Range on Protein: 66-165
Range on HMM: 127-269/297.0
RFVINLTKTTRY----------------------YEAEEfGNDV--------------HTQQIQCAGHGERPTPEQVKVFIHVCKTFWQKQ----PGCTI
. ...|||.. .                       . |.  ...              . ...|. |  .  .|. .........  .. .    .|. .
tvivmLtklvelgrkcaqywpeeggtygdftvtllkveh.ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpv

GVHCTHGFNRTGFMICCYLI-----EEMDCAVEDALQLFAKSRdP
 |||..| .||| .|..||.     .| .  |..|.. . . | |
lVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR.p
0036282 (Phosphotyrosine protein) phosphatases II 67-163 3.1e-19 64.8 In-house 53-146 (174) alignment 
Range on Protein: 67-163
Range on HMM: 53-146/174.0
FVINLTKTTRYYeaeEFGNDVHTQQIQCAGHGERPTPEqVKVFIHVCKTFWQKQPGCTIGVHCTHGFNRTGFMICCYLIEEMDC-AVEDALQLFAKSR
 .||.. ..|..   .  .... ... . .||. .... .  |.  .... .. ||... |||..|..|||.....||.. . .  ..|||.|... |
kcinywpelred...lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelR
0043336 (Phosphotyrosine protein) phosphatases II 67-165 1.5e-12 43.0 In-house 115-257 (278) alignment 
Range on Protein: 67-165
Range on HMM: 115-257/278.0
FVINLTKTT-------------------------------------------RYYEAEefgndVHTQQIQCAGHGERPTPEQVKVFIHVCKTFWQK--QP
 ...||. .                                           ...  .      . ..... |  .  .||... ... .|.....   .
tivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdges.....rtvthyhylgwpdhgvpeslsllldflkavrealeds

GCTIGVHCTHGFNRTGFMICCYLI-----EEMDCAVEDALQLFAKSRdP
.  . |||..| .||| .|..||.      |    .|.|.. . . | |
ngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR.p
PTPc_motif_SM00404 67-167 8.5e-12 40.1 In-house 30-124 (140) alignment 
Range on Protein: 67-167
Range on HMM: 30-124/140.0
FVINLTKTTRYYeaeefG--NDVHTQQIQCAGHGERP---TPEQVKVFIHVCktfwqKQPGCTIGVHCTHGFNRTGFMICCYLIEEMDCAVEDALQLFAK
.|||.|.. .          ....  ||.   ... .     ..|. ||. .     .. |... |||..| .|.. .|..||.... . ...|.... .
hvinvteevslt.....kensgfqilqiplddnekdklskyldkvldfiena.....ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvke

SRdPGI
 | | |
rR.pii
0049260 (Phosphotyrosine protein) phosphatases II 68-170 1.6e-17 59.1 In-house 37-136 (152) alignment 
Range on Protein: 68-170
Range on HMM: 37-136/152.0
VINLTKTTRyYEAEEFG--NdvHTQQIQCAGHGERPTPEQVKVFIHVCKTFwQKQPGCTIGVHCTHGFNRTGFMICCYLIEeMDCAVEDALQLFAKSRDP
...||. .     . .      . .....  ||  . .. .. ...... . ....|... |||..|..|||.....||.. ... .|.|..|. . |  
ivmltelle.lgklkceqyi..qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvrekRpg

GIYKY
...  
avpnp
0047943 (Phosphotyrosine protein) phosphatases II 69-163 8.4e-11 37.3 In-house 148-251 (273) alignment 
Range on Protein: 69-163
Range on HMM: 148-251/273.0
INLTKTTRYYEAEEFGNDVHTQQIQCAGHGERPTPEQVKVFIHVCKTFWQKQP----GCTIGVHCTHGFNRTGFMICCYLI-----EEMDCAVEDALQLF
 . |..| . .  ..|.  . ..... |  .  .|.... ... ..  ....     . .. ||| .| .||| .|...|.     .|    |..|..|.
ddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkll

AKSR
 . |
rsqR
0050432 (Phosphotyrosine protein) phosphatases II 70-163 7.2e-13 44.0 In-house 180-278 (308) alignment 
Range on Protein: 70-163
Range on HMM: 180-278/308.0
NLTKTTRYYEAEEFGNDVHTQQIQCAGHGERPTPEQVKVFIHVCKTFWQKQPGCTIGVHCTHGFNRTGFMICCYLI-----EEMDCAVEDALQLFAKSR
. |..| . .  . |.  . ..... .  .  .|.... ... ..   ...||..| ||| .| .||| .|...|.     .|  . |..|.. . . |
dytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqR
0036941 (Phosphotyrosine protein) phosphatases II 71-163 2e-10 36.0 In-house 109-256 (297) alignment 
Range on Protein: 71-163
Range on HMM: 109-256/297.0
LT--------KTTRYYEAE-----------------------------------EFGNDVHTQQIQCAGHGERPTPEQVKVFIHVCKTFWQKQ----PGC
||        |  .|.  |                                   . |.  . ..... |  .  .|| .. ... .. .....    .| 
ltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsgg

TIGVHCTHGFNRTGFMICCYLI--------EEMDCAVEDALQLFAKSR
 . ||| .| .|.| .|...|.        .|  . . .|.. . . |
pvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqR
subfamily_PTPMT1_pd Subfamily PTPMT1 73-164 6.3e-07 24.0 In-house 64-149 (171) alignment 
Range on Protein: 73-164
Range on HMM: 64-149/171.0
KTTRYYEAEefgnDVHTQQIQCAGHGERPTPEQVKVFIHVCKTFWQKqpGCTIGVHCTHGFNRTGFMICCYLIEEMDCAVEDALQLFAKSRD
..|. .. .    .|.  |..   . | |. |...  ... . . .|  | .. |||  |  |.. .. |||. .  .  |.||.  .| |.
nsteewkkl....gveqlqlatvDfteapdleklekgvefiekvask..gkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRk
0051299 (Phosphotyrosine protein) phosphatases II 76-163 4.8e-11 38.1 In-house 167-265 (288) alignment 
Range on Protein: 76-163
Range on HMM: 167-265/288.0
RYYEAE----EFGNDVHTQQIQCAGHGERPTPEQVKVFIHVCKTFWQK--QPGCTIGVHCTHGFNRTGFMICCYLI-----EEMDCAVEDALQLFAKSR
 . .        |.  . ..... .  .  .|. .. ... .. ....  ..|... ||| .| .||| .|...|.     .|  . |..|.. . . |
levtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqR
DSPc_SM00195 76-144 8.9e-06 20.6 In-house 154-217 (263) alignment 
Range on Protein: 76-144
Range on HMM: 154-217/263.0
RyyeaeefGNDVHTQQIQCAGHGERPTPEQVKVFIHVCKTFWQKQP--GCTIGVHCTHGFNRTGFMICCYL
.        ..  ..|.|. .  .. .|.. | .... ... ...     .| |||  | .||| ...  .
k.......eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidi
PTPc_SM00194 76-144 8.9e-06 20.6 In-house 154-217 (263) alignment 
Range on Protein: 76-144
Range on HMM: 154-217/263.0
RyyeaeefGNDVHTQQIQCAGHGERPTPEQVKVFIHVCKTFWQKQP--GCTIGVHCTHGFNRTGFMICCYL
.        ..  ..|.|. .  .. .|.. | .... ... ...     .| |||  | .||| ...  .
k.......eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidi
subfamily_PRL_pd Subfamily PRL 78-164 1.9e-10 35.0 In-house 46-131 (151) alignment 
Range on Protein: 78-164
Range on HMM: 46-131/151.0
YEAEEFG-NDVHTQQIQCAgHGERPTPEQVKVFIHVCKTFWQKQPGCTIGVHCTHGFNRTGFMICCYLIEEmDCAVEDALQLFAKSRD
|..|..  .... .... .  |  |. | |. .....|. ....|..|..|||  |. |.  ...  |||.     |||...  . | 
ydteklekegievldlafd.dGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalaliea.Gmkyedavefirekrr
0046845 (Phosphotyrosine protein) phosphatases II 80-164 6.7e-12 40.8 In-house 161-254 (284) alignment 
Range on Protein: 80-164
Range on HMM: 161-254/284.0
AEEFGNDVHTQQIQCAGHGERPTPEQVKVFIHVCKTFWQK-QPGCTIGVHCTHGFNRTGFMICCYLIEEM--------DCAVEDALQLFAKSRD
 .|     | . ..   ||  |.||..  |.. .... ..  .|..| ||| .| .||| .|...|. |.         . |..|.. . . | 
tgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRp
Y_phosphatase Protein-tyrosine phosphatase 85-145 6.3e-06 21.1 Pfam-A 131-193 (235) alignment 
Range on Protein: 85-145
Range on HMM: 131-193/235.0
NDVHTQQIQCAGHGERPTPEQVKVFIHVCKTFWQKQ--PGCTIGVHCTHGFNRTGFMICCYLI
.  ...|... .  .. .||..| ...... . ...      . ||| .| .||| ...  ..
ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil
Y_phosphatase Protein-tyrosine phosphatase 85-145 6.3e-06 21.1 In-house 131-193 (235) alignment 
Range on Protein: 85-145
Range on HMM: 131-193/235.0
NDVHTQQIQCAGHGERPTPEQVKVFIHVCKTFWQKQ--PGCTIGVHCTHGFNRTGFMICCYLI
.  ...|... .  .. .||..| ...... . ...      . ||| .| .||| ...  ..
ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil
PTPc_DSPc_SM00012 93-147 1.7e-06 23.5 In-house 6-64 (105) alignment 
Range on Protein: 93-147
Range on HMM: 6-64/105.0
QCAGHGERPTPEQVKVFIHVCKTFWQKQPG----CTIGVHCTHGFNRTGFMICCYLIEE
.. |  .  .||... ...... . ...        . ||| .| .||| ... ... .
hytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillq
subfamily_PTPDC1_pd Subfamily PTPDC1 106-176 1.1e-08 29.7 In-house 101-168 (182) alignment 
Range on Protein: 106-176
Range on HMM: 101-168/182.0
VKVFIHVCKTFWQKQpgcTIGVHCTHGFNRTGFMICCYLIEEMDCAVEDALQLFAKSRDPGIYKYGKATFF
.   . | .   |..    ..|||  |  ||| .|.|||.   . . |.|..|  . |   |.  ..  . 
iLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelv
mRNA_cap_enzyme mRNA capping enzyme, catalytic domain 389-585 2.5e-50 160.2 Pfam-A 1-192 (192) alignment 
Range on Protein: 389-585
Range on HMM: 1-192/192.0
QPVSLNRDSLLDLSRADYMISWKSDGTRYLMLLADQKVYFVGRDNNYFCVAgKVRFPNQD---LKSVHQNTLLDGEMVYDCWKDpatkkkQYRARFYIFD
|||||.|. |  |. .||..|.|.||.|.|.|.....||.. |||... |  ...||..     . ||..||||||.| |  ..      . . |..|.|
qpvslsrenlkllkqkdYyvseKaDGlRvlllitkkevylidrdnevylve.nlkfplklekekekvhhgtllDGElvidtvee......eqklryliyD

MIACNGESFRHKPYNERLEAVQTHILNPRLKQStWPGYKEKYAQEPFSVRLKPFLPLADFQSDQWRKMRSQVQHKDDGLLLVRVAHEYKAGSCKALLKWK
..|.|||.  ..| ..|||.... |..|| ..      . |...|||.|||| |..|   .     |.  .. |. ||| .. | . |.|| .| |||||
ilaingelvserplskRleilkkeiikpraeek.lkthiiktelepfkvrlksfilllalekllskkkikklsheiDGLIfqsvdtpYvagrdknllKWK
DNA_ligase_A_M ATP dependent DNA ligase domain 403-510 6.6e-13 37.6 Pfam-A 18-144 (202) alignment 
Range on Protein: 403-510
Range on HMM: 18-144/202.0
RADYMISWKSDGTRYLMLLADQKVYFVGRDNNYFCVA--GKVRFPNQDLKSVHQNTLLDGEMVY-----------DCWKDPATKKK------QYRARFYI
........| || |  .   ...|... |  . .  .    . . .. ... ... .||||.|.             ..... |||      .....|..
egafiveeKyDGeRvqvhkdgdevkllSRrgkditakkpellkalkeaflkdvksvildGElvavdketgeilpfqtlasrknkkkvkveekeaelsffv

FDMIACNGESFRHKPYNERLEAVQTHI
||.. ..|||. ..|..|| . ... .
FDvlyldgesltdepleeRrklLeeif
mRNA_cap_C mRNA capping enzyme, C-terminal domain 589-698 2.9e-18 55.6 Pfam-A 2-103 (105) alignment 
Range on Protein: 589-698
Range on HMM: 2-103/105.0
LNTIDFRLKVEDIG-----DRTVGTL-YVQdvrgrgserpevkfT--------GmgspelntFVPQERQQLWAYDGKIVECNWLSDLNRWNILLERKDKT
|||.||.||.|.       ....| | ||.                                   .  ...  ..||||||..  . .||..| .||||.
lntvDfllklekeeedglLeeekgkldyve..............ggsdefitak........ekeklksdekelkgkIvEcklddkkgrWkflriRkDKs

HPNAFHTAINVVGSIRDGIELREL
.|| ..|| .|. ||.|...  ||
epNsistaekvlksiednvtkeeL