Gene RNGTT-2 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily RNGTT
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP018_AA protein Get Run
MbreP018_AA_351-481 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Abhydrolase_5 Alpha/beta hydrolase family 98-265 2.1e-13 36.7 Pfam-A 60-145 (145) alignment 
Range on Protein: 98-265
Range on HMM: 60-145/145.0
TARNVLIGHSYGTSLVVQLYQslptsfqsqvvglvccnavtqdascllqasmralslvptpvlglirrwqarrgsESQSVARMVAADAtnetkvmqlHwn
. | .|.|||.|......| .                                                      . ..|. .|. ..         .  
lervilvGhSlGGgvalelag......................................................rddrvkglvllap.........f..

twtpthvlqamaaglqvVSLADYARVTIPVLLLAGAEDTVVPPEHTYSIYDTVPRVHGPHIAPNAKHN
                  . .| |..|.||||. |..|.|||||.   ... .|  .  .. ..| |.
.................pdgedlakltlpvllihGtrDgvvppeeaeklakalpgdaelvviegasHf
Abhydrolase_6 Alpha/beta hydrolase family 99-276 1.5e-18 53.8 Pfam-A 66-227 (228) alignment 
Range on Protein: 99-276
Range on HMM: 66-227/228.0
ARNVLIGHSYGTSLVVQLYQSLPTsfqsQVVGLVCCNAVTQ-----DascllqasmralslvptpV---LGLIRRWQARRGSESQSVARMVAADATNETK
.. ||.|||.|....... .. |      | ||| .... .     .                        |.||. |.|    . .|.   |.. ... 
gpvvlvGHSlGgavalaaaarrpd....lvrglvlidppgplpaspl..................rpagppllrrllagraaalrdlaarafarlfdgde

VMQLHWNtwTPTHVLQAMAA-GLQVVSLADYARVTIPVLLLAGAEDTVVPPEHTYSIYDTVPRVHgPHIAPNAKHNLIEEASELVNA
...|  .  . ....... |  |.    ...||...|||..||..| |||||.   . . .|..   .. |.| |.| .|| . |..
lealvra..daaalaellraalldadlrealarldvPvlviageaDrvvppeearrlaealpgar.vvvlpgagHllfleapdevae
Abhydrolase_1 alpha/beta hydrolase fold 102-279 5.5e-12 33.0 Pfam-A 47-229 (230) alignment 
Range on Protein: 102-279
Range on HMM: 47-229/230.0
VLIGHSYGTSLVVQLYQSLPTsfqsQVVGLVCCNAV----TQDASCLLQAsMRALSLVPTPVLG-LIRRWQARRGSES---QSVARMVAADATNETKVMQ
.|.|||.|. .. ....  |.     | ..|....|    .   | .|.. .  | |.  .| | | .. .. .|  |   ||. |    |  .. .  .
tlvGhSmGGmialayaaeypd....rvkamvllgtvavlsdglssdvlnr.gstltlladnvagrlskgikplqgdasvqaqsllrpqvtdflkrfdans

LHW---NTWTPTHVLQAMAAGLQVVSLADYARVTIPVLLLAGAEDTVVPPEHTYSIYDTVPRvHGPHIAPNAKHNLIEEASELVNALLT
. .   ....... |.|..  |.    ..  ....|.|.. | .| .||... ... ...|. .  .  ... | . ... ...|.|..
yaregetraldgkllaalgrdlvwdvtetlktilvptlvisgtdDplvpykaseklaelipk.sqlvvidgpgHlafldkpdeinkliv
Peptidase_S9 Prolyl oligopeptidase family 177-253 8.6e-07 14.7 Pfam-A 98-173 (213) alignment 
Range on Protein: 177-253
Range on HMM: 98-173/213.0
VARMVAADATNETkVMQLHWNTWTPTHVLQAMAAGLQVVSLADYARVTIPVLLLAGAEDTVVPPEHTYSIYDTVPRV
|. ... . ...   .. ... ..     ...   |. .| ||  ... |.||. | ||. |||.... ....  . 
vvdwltymsdtsl.lteaeymeygnpeeneegyeelspyspadnvkaypplllihGeeDdrvppaealklvaaLqka
AXE1 Acetyl xylan esterase (AXE1) 213-269 4.5e-06 11.6 Pfam-A 253-307 (320) alignment 
Range on Protein: 213-269
Range on HMM: 253-307/320.0
QVVSLADyaRVTIPVLLLAGAEDTVVPPEHTYSIYDTVPRVHGPHIAPNAKHNLIEE
 |. ||.  |.  |||| .| ||.| ||   ...|  .      .. .. .|. ...
DvknlAk..rikapvllavgLeDkvcpPstvfaaynkleteKelkvyeeyahealka
PhoPQ_related PhoPQ-activated pathogenicity-related protein 220-278 6.7e-06 11.1 Pfam-A 257-314 (367) alignment
FSH1 Serine hydrolase (FSH1) 220-263 8.5e-06 11.7 Pfam-A 157-206 (212) alignment 
Range on Protein: 220-263
Range on HMM: 157-206/212.0
YARVTIPVLLLAGAEDTVVPPEHTYSIYDTVPR------VHGPHIAPNAK
  ....|.|   | .||||..| . ...... .       .| |  || |
edkiqtpsLhvlGelDtvvdeerseaLaeafknsskvlkHpggHfvPnkk
0038934 (Phosphotyrosine protein) phosphatases II 352-479 1.7e-23 78.7 In-house 48-176 (194) alignment 
Range on Protein: 352-479
Range on HMM: 48-176/194.0
KAFKTKFTNVGLVIDVSREPPPYltNAPDVP----PYVKIATVSK-REPEAESVAKLHKVLDNFWANpdNARKDVIIHCHYGFNRSGFMACSYLVKRRGF
. .|..  ..|||||.. . . |  .. ...     |.|. ....   |  | . .  ...| | ..  .. . | .||..|..|.|.....||..|.|.
rylkllnvklglvidltnteryY..dpeefekagieylklpfpddgtvPsleillrfldlvdeflne..dpggvvaVHCkaGlgRtGtlvaaYLiyrlgm

GAREALHAFRKARPPGIKHEHFRAEFLRRYASV
 |.||.. || .||..| . ..  ..|.||  .
saeeAialfrekRpgaipnqdyleallkrykel
subfamily_RNGTT_pd Subfamily RNGTT 354-481 7.6e-45 146.9 In-house 48-176 (189) alignment 
Range on Protein: 354-481
Range on HMM: 48-176/189.0
FKTKFTNVGLVIDVSREPPPYLTNAPDV--PPYVKIATVSKRE-PEAESVAKLHKVLDNFWAnpDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGARE
.||. ...|||||.... ..| ... .     |||... .|.| ||||.|....|....|..  .|... ...||..||||.||...||||... .....
lktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffk..knpeevigvhCthGfnRtGFlivsyLvekedwsvea

ALHAFRKARPPGIKHEHFRAEFLRRYASVNS
|...|.|||||||..|....|.|||||.|..
avalFakaRppGiykedylkellrrYadvee
subfamily_DSP11_pd Subfamily DSP11 357-471 1e-18 61.9 In-house 53-169 (178) alignment 
Range on Protein: 357-471
Range on HMM: 53-169/178.0
KFTNVGLVIDVSREPPPYLTNAP-DV-PPYVKIATVSKREPEAESVAKLHKVLDNFWANPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHA
| ...|||||..     | ...  |    |.|. .. .. |. | | |.......|  . ..  | . .||  | ||.|.. | ||... |. ...|..|
knkklGLvidltntdryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaiea

FRKARPPGIKHEHFRAE
| .||   . .|..  .
feearGhslerenylkd
DSPc Dual specificity phosphatase, catalytic domain 357-471 2.6e-14 48.2 Pfam-A 15-126 (133) alignment 
Range on Protein: 357-471
Range on HMM: 15-126/133.0
KFTNVGLVIDVSREPPPYLTNAPDVPPYVKIAtVSKrEPEAESVAKLHKVLdNFWANPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFR
.  .. |||.|..| |   . ..    |..|  |   | |.. ...| ..  .| .. .. .| |..||  | .||. ... || |.... ..||.....
eklgitlvinvtkevpnnnaikkseieylrip.ved.etetkiskeleeav.efiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvk

KARpPGIKHE-HFRAE
. | . | .  .| ..
err.skispnagflrq
DSPc Dual specificity phosphatase, catalytic domain 357-471 2.6e-14 48.2 In-house 15-126 (133) alignment 
Range on Protein: 357-471
Range on HMM: 15-126/133.0
KFTNVGLVIDVSREPPPYLTNAPDVPPYVKIAtVSKrEPEAESVAKLHKVLdNFWANPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFR
.  .. |||.|..| |   . ..    |..|  |   | |.. ...| ..  .| .. .. .| |..||  | .||. ... || |.... ..||.....
eklgitlvinvtkevpnnnaikkseieylrip.ved.etetkiskeleeav.efiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvk

KARpPGIKHE-HFRAE
. | . | .  .| ..
err.skispnagflrq
0048179 (Phosphotyrosine protein) phosphatases II 359-470 4.1e-16 54.5 In-house 28-135 (144) alignment 
Range on Protein: 359-470
Range on HMM: 28-135/144.0
TNVGLVIDVSREPPPYLTNAPdVPPYVKIATVSKREPEA-ESVAKLHKVLDNFWANPdnarKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRK
 ....||... | .|.    . .  |... .     |.  | . .. . .... ...    . |..||..|..|.|.... ||.|..|. . |||. .|.
lgittvinlteeyepeflere.giqylhlpwpDhgvpdllellleflefieealeeg....gpvlVHCsaGvgRtgtlvaaylmkklglsleealalvrs

ARPPGIKHEHFRA
.|| .. ..... 
rrpgavpnpgqlr
0048076 (Phosphotyrosine protein) phosphatases II 359-470 5.7e-16 54.0 In-house 28-133 (145) alignment 
Range on Protein: 359-470
Range on HMM: 28-133/145.0
TNVGLVIDVSREPPPYLtnaPDVPPYVKIATVSKREPEA-ESVAKLHKVLDNFWANPdnarKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRK
 ....|.....|.. .    . .  |. . .    .|.  | . .. . .... ...    . |..||. | .|.|.... ||....|. . |||. .|.
lgittvlnltselelle...rlgiqylylpwpDhgvpdllellleflefieealkeg....gpvlVHCsaGvgRtgtlvaaylmlllgvsleealelvrs

ARPPGIKHEHFRA
.|| .. ..... 
qrpgavpnpgqlr
PTPc_motif_SM00404 359-470 6.4e-13 43.8 In-house 26-132 (140) alignment 
Range on Protein: 359-470
Range on HMM: 26-132/140.0
TNVGLVIDVSREPP-PyltnapDVPPYVKIATVSKREPEAESVAKLHKVLDNFWANPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRK
 .. .||.|..| . .      .  . ..|  .  .. | . ..|  . . .|  |  . .. |..||  | .||. ... || ..|.. ..||......
lgithvinvteevslt......kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvke

ARpPGIKHE-HFRA
 | | |..  .| .
rR.piispnlnfvr
0044763 (Phosphotyrosine protein) phosphatases II 360-471 1.9e-16 55.7 In-house 48-162 (178) alignment 
Range on Protein: 360-471
Range on HMM: 48-162/178.0
NVGLVIDVSREPPPY----LTNAPDV--PPYVKIATVSKREPE-AESVAKLHKVLDNFWANPDnarKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREAL
......... | ...    .  .|.     |..| ..   .|.  | . .... .... ....   . |..||..|..||| ... ||.|..|. . ||.
githivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekg...gpvlVHCsaGvgRsgtlvaaylmkklglsleeai

HAFRKARPpGIKHEHFRAE
. .|..|| .. .....  
elvrerRp.ivpnpgqlrq
0043147 (Phosphotyrosine protein) phosphatases II 360-470 5.7e-15 50.9 In-house 44-151 (172) alignment 
Range on Protein: 360-470
Range on HMM: 44-151/172.0
NVGLVIDVSREPPPYLTNAPDVPPYVKIATVSKREPEAESVAKLHKVLDNFWANPDNarKDVIIHCHYGFNRSGFMACSYLVKrRGFGAREALHAFRKAR
........ ..  ..    . .  |  .       | .| . .. . .|.. |. ..  . |..||..|..|.|.... ||.. .|. . ||.. .|..|
githivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspg..gpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekR

PPGIKHEHFRA
| .. ..... 
pgavqnpsqyr
0041856 (Phosphotyrosine protein) phosphatases II 360-466 9.9e-15 50.0 In-house 58-157 (182) alignment 
Range on Protein: 360-466
Range on HMM: 58-157/182.0
NVGLVIDVSrePPPYLTNAP--DVPPYVKIATVSKREPEAESVAKLHKVLDNfwanpdnARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRK
.........  ...|  .     .  |...       |. ... .. .   .         . |..||..| .|.|.... ||.|..|....||.. .|.
gittivnlt..eelywpellerlgiqylylpwpDhgvpdldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrs

ARPPGIKHE
.|| .. ..
rRpgmvitp
0042113 (Phosphotyrosine protein) phosphatases II 360-468 6.6e-13 44.1 In-house 76-231 (245) alignment 
Range on Protein: 360-468
Range on HMM: 76-231/245.0
NVGLVIDVSREPPP-------------------------------------------YLTNAPDVPPYVKIATVSKREPE-AESVAKLHKVLDNFWANpd
..  ......| .                                            .      |  |  .      .|.  |.. .... .... |.  
gittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae..

NARKDVIIHCHYGFNRSGFMACSYLV-----KRRGFGAREALHAFRKARPPGIKHEHF
.. . |..||. | .|.| ... ||.     |..|. . ||.. .|. ||  .  ...
dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsq
0051082 (Phosphotyrosine protein) phosphatases II 360-463 3.2e-11 38.5 In-house 33-136 (151) alignment 
Range on Protein: 360-463
Range on HMM: 33-136/151.0
NVGLVIDVSREPPPYlTNAPDVPP----YVKIATVSKREPEA----ESVAKLHKVLDNfwanpdNARKDVIIHCHYGFNRSGFMACSYLVKrRGFGAREA
..  ....  |.... ...  .|     .. |  ..  .|      ..|......|..      .  . |..||. | .|.|.... ||.. .|. . ||
giktivnlrseeerg.ycpeylpelgievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylml.lgvsleea

LHAFRKARPPGI
|. .|. ||  .
leeyrlkrpgvv
0051429 (Phosphotyrosine protein) phosphatases II 360-479 1.1e-10 37.2 In-house 45-231 (272) alignment 
Range on Protein: 360-479
Range on HMM: 45-231/272.0
NVGLVIDVSREPPPYLTNAPDVPP---YVKIATVSKREPEA----------------------------------------------------ESVAKLH
..  ..|. .|      . . ..|   |. . ...  .|.                                                     |.. .| 
giktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallell

KVLDNfwanpdnaRKDVIIHCHYGFNRSGFMACSYLVKrRGFG--------------AREALHAFRKARPPGIKHEH-------FRAEFLRRYASV
..| .         . |..||. | .|.|.... .|.  .|..              ..||..  |..||  . .|.       . .|.||...||
ellld........ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsllsv
subfamily_DSP14_pd Subfamily DSP14 360-460 2.5e-06 21.5 In-house 31-125 (157) alignment 
Range on Protein: 360-460
Range on HMM: 31-125/157.0
NVGLVIDVSREPPPylTNAPDVPpYVKIATvsKREPEAESVAKLHKVLDNFwANPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRKAR
.. |.|.|..| |   |...|.  .||..   . .|||. .. . .| |.   . ...   ...||  |  ||  ..  ||.| .    ||| .. ..||
kitliinvtvelpn..tklkdie.rvkvpv..eDnpeaklakhfdevadki.eevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaR

P
|
p
0049260 (Phosphotyrosine protein) phosphatases II 362-470 1e-14 49.9 In-house 35-140 (152) alignment 
Range on Protein: 362-470
Range on HMM: 35-140/152.0
GLVIDVSREPPPYLTNAPDVPPYVKIATVSKREPEAESVAKLHKVLDNFWanPDNARKDVIIHCHYGFNRSGFMACSYLVKrRGFGAREALHAFRKARPP
. .. . .. . .    .  . |  . .     |. . . .    .....    .  . |..||..|..|.|.... ||.. .|. . ||.  .|..|| 
ttivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvrekRpg

GIKHEHFRA
.. ..... 
avpnpgqlr
subfamily_DSP23_pd Subfamily DSP23 363-464 5.3e-11 37.4 In-house 34-130 (148) alignment 
Range on Protein: 363-464
Range on HMM: 34-130/148.0
LVIDVSREPPPYLTNAPDVPpYVKIATVSKREPEAESVAKLHKVLDNfwAnpDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRKARPPG
 .. .. | .|    .|..  .|..       |  | | .. .|...  |  ..  . | .||  |. |.| |   |||| |.. | ||.   |. ||  
ylvslteegrphveatpnlt.lvrlriddyhppaleqvvefvrvvee..a..eekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgs

IK
..
ve
0036282 (Phosphotyrosine protein) phosphatases II 377-469 1.6e-15 52.7 In-house 65-159 (174) alignment 
Range on Protein: 377-469
Range on HMM: 65-159/174.0
NAPDVPPYVKIATVSKREPEAESVAKLHKVLDNFWANpdNARKDVIIHCHYGFNRSGFMACSYLVKRRGF-GAREALHAFRKAR---PPGIKHEHFR
  . .  |... ..   .|. . . .. | .... ..  .  . |..||. |..|.|.... ||..|... ....||. .|..|   |... .....
lerlgiqylylpwpDhgvpdlsillefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQy
0037934 (Phosphotyrosine protein) phosphatases II 379-468 1.3e-13 46.6 In-house 133-230 (243) alignment 
Range on Protein: 379-468
Range on HMM: 133-230/243.0
PDVPPYVKIATVSKREPE-AESVAKLHKVLDNFWAN-----PDNARKDVIIHCHYGFNRSGFMACSYLVKRR-GFGAREALHAFRKARPP-GIKHEHF
  |  |  ..      |.  |.. .... . .|  .      ..  . |..||. | .|.| ... ||.... |... ||.. .|. ||  ..  ...
rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsq
0049772 (Phosphotyrosine protein) phosphatases II 384-477 2.9e-16 55.5 In-house 183-270 (314) alignment 
Range on Protein: 384-477
Range on HMM: 183-270/314.0
YVKIATVSKREPEAESVAKLHKVLDNFwanpdNARKDVIIHCHYGFNRSG-FMACSYLVKRRGFGAREALHAFRKARPPGIKHeHFRaEFLRRYA
|. | .    .|  | . .. ......     .. . |..||. | .|.| |... ||.|..|. ..|||. .|..|| .... .|. |.|..| 
ylripvpDgsaplledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRpinpnp.gfi.eqleqye
0046846 (Phosphotyrosine protein) phosphatases II 392-468 4.5e-13 44.8 In-house 87-161 (176) alignment 
Range on Protein: 392-468
Range on HMM: 87-161/176.0
KREPEAESVAKLHKVLDNFWANPdnarKDVIIHCHYGFNRSGFMACSYLVKR-RGFGAREALHAFRKARP-PGIKHEHF
   |. | . .| . ....  .     . |..||. | .|.| ... ||... .|. . |||. .|. ||   . ....
hgvpdlelllellefirealkeg....gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQ
subfamily_DSP19_pd Subfamily DSP19 395-461 2e-07 25.5 In-house 67-132 (152) alignment 
Range on Protein: 395-461
Range on HMM: 67-132/152.0
PEAESVAKLHKVLDnFWANPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRKARPP
||.. .. |...|| |  .  ..   |..||. |  ||  .. .||.|..    .|||.  |.|||.
petdllsylkeald.FieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpc
0040439 (Phosphotyrosine protein) phosphatases II 396-468 3.3e-12 42.0 In-house 158-234 (249) alignment 
Range on Protein: 396-468
Range on HMM: 158-234/249.0
EAESVAKLHKVLDNFWANPdNARKDVIIHCHYGFNRSGFMACSYLV-----KRRGFGAREALHAFRKARPPGIKHEHF
  |.. .. . .... ..  .  . |..||. | .|.|.... ||.     |..|. . ||.. .|..|| ..  ...
sfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeq
0046845 (Phosphotyrosine protein) phosphatases II 397-464 1.2e-08 30.2 In-house 184-258 (284) alignment 
Range on Protein: 397-464
Range on HMM: 184-258/284.0
AESVAKLHKVLDNFWANpDNARKDVIIHCHYGFNRSGFMACSYLVKRR--------GFGAREALHAFRKARPPGIK
.|.. .. . ....  |  .  . ...||. | .|.| ... .|....        |. . ||.. .|. ||  . 
pedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvq
subfamily_DSP1_pd Subfamily DSP1 397-460 9.3e-06 19.8 In-house 74-137 (163) alignment 
Range on Protein: 397-460
Range on HMM: 74-137/163.0
AESVAKLHKVLDNFWANPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRKARP
 . . .. .   .|  .  ...  |.|||. |  ||  .   ||.|.. .   || .  .. |.
kadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRs
0040438 (Phosphotyrosine protein) phosphatases II 398-465 1.2e-11 39.9 In-house 192-261 (317) alignment 
Range on Protein: 398-465
Range on HMM: 192-261/317.0
ESVAKLHKVLDNFWAnpdNARKDVIIHCHYGFNRSGFMACSYLV-----KRRGFGAREALHAFRKARPPGIKH
... .. . .... .   .  . |..||. | .|.|.... ||.     |..|. . ||.. .|..|| ..  
dllldfleavreale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqt
subfamily_DSP10_pd Subfamily DSP10 398-460 7.6e-06 19.9 In-house 72-134 (159) alignment 
Range on Protein: 398-460
Range on HMM: 72-134/159.0
ESVAKLHKVLDNFWANPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRKARP
. . .  ..  .|  .  .  . |..||. |  ||  .. .||.|...   ..| .  ...||
qnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrp
0045450 (Phosphotyrosine protein) phosphatases II 399-468 1.1e-11 40.5 In-house 216-292 (307) alignment 
Range on Protein: 399-468
Range on HMM: 216-292/307.0
SVAKLHKVLDNFWANPdNARKDVIIHCHYGFNRSGFMACSYLVKRRG--------FGAREALHAFRKARPPGIKHEHF
.. .. . .... ..  .  . |..||. | .|.| ... ||..|..        . ..||.. .|. || ..  ...
elldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeq
0039614 (Phosphotyrosine protein) phosphatases II 399-468 1.4e-11 39.9 In-house 204-277 (297) alignment 
Range on Protein: 399-468
Range on HMM: 204-277/297.0
SVAKLHKVLDNFWANPdNARKDVIIHCHYGFNRSGFMACSYLV-----KRRGFGAREALHAFRKARPPGIKHEHF
.. .. . .... |.  .  . |..||. | .|.| ... ||.     |..|. . ||.. .|..|| ..  ...
llleflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsq
0050432 (Phosphotyrosine protein) phosphatases II 399-463 3e-08 28.8 In-house 218-282 (308) alignment 
Range on Protein: 399-463
Range on HMM: 218-282/308.0
SVAKLHKVLDNFWanPDnarKDVIIHCHYGFNRSGFMACSYLV-----KRRGFGAREALHAFRKARPPGI
.. .. . ....   |.   . ...||. | .|.| ... .|.     | .|. . ||.. .|. ||  .
illdflelvrksl..pg...gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmv
subfamily_PTPMT1_pd Subfamily PTPMT1 399-479 1.1e-07 26.5 In-house 89-167 (171) alignment 
Range on Protein: 399-479
Range on HMM: 89-167/171.0
SVAKLHKVLdNFWANPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRKARPpGIKHEHFRAEFLRRYASV
...||.| . .|  .  .  | | .||. |  ||. .. .||.|.. .   |||.| .| |.  |. .... . |..| . 
dleklekgv.efiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRk.iirlakkqwkalqeyeek
PTEN_1 400-481 1.8e-19 65.3 In-house 113-193 (196) alignment 
Range on Protein: 400-481
Range on HMM: 113-193/196.0
VAKLHKVLDNFWANPDNaRKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRKARPPGIKHEHFRAEFLRRYASVNS
. .  |.... . . .| .. |..||. | .|||.....||...... |.|||  .|..|||| ..  .. ..|. .|. ..
lfdicksfiewllsdpn.gnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaella
0048567 (Phosphotyrosine protein) phosphatases II 400-463 1.1e-11 39.3 In-house 56-122 (157) alignment 
Range on Protein: 400-463
Range on HMM: 56-122/157.0
VAKLHKVLDNFWANPDNARKDVIIHCHYGF---NRSGFMACSYLVKRRGFGAREALHAFRKARPPGI
. .. ..|..|.  ...|.| ...||..|     |.......||... || ..||.. .| .||. .
lyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsv
0036941 (Phosphotyrosine protein) phosphatases II 400-465 6.6e-09 30.9 In-house 190-262 (297) alignment 
Range on Protein: 400-465
Range on HMM: 190-262/297.0
VAKLHKVLDNFWANPdNARKDVIIHCHYGFNRSGFMACSYLV--------KRRGFGAREALHAFRKARPPGIKH
. .. . .... ..  .  . |..||. | .||| ... .|.        |..|.   ||.. .|. ||  .  
lldfielvrkvlkll.psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqt
subfamily_PTEN_pd Subfamily PTEN 400-459 6.1e-07 24.6 In-house 98-156 (184) alignment 
Range on Protein: 400-459
Range on HMM: 98-156/184.0
VAKLHKVLDNfWANPDNaRKDVIIHCHYGFNRSGFMACSYLVKRRGFGAR-EALHAFRKAR
.... . ... | . |. .. |..||. |  |.| . ..||.|.. .    |||. | .||
leeivediek.wleedk.knvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaR
0043336 (Phosphotyrosine protein) phosphatases II 402-464 1.1e-09 33.6 In-house 197-261 (278) alignment 
Range on Protein: 402-464
Range on HMM: 197-261/278.0
KLHKVLDNFWAnpdNARKDVIIHCHYGFNRSGFMACSYLV-----KRRGFGAREALHAFRKARPPGIK
.. |..... .   .  . |..||. | .|.| ... ||.     |..|. . ||.. .|. ||  . 
dflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavq
subfamily_CDC14_pd Subfamily CDC14 405-462 5.2e-07 23.8 In-house 250-307 (328) alignment 
Range on Protein: 405-462
Range on HMM: 250-307/328.0
KVLDNFWANPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRKARPPG
... .| .  ..|.  ...||. |. | | .  .||.|. .| | ||.  .| .||  
aivkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGs
0051299 (Phosphotyrosine protein) phosphatases II 406-463 8.7e-08 27.4 In-house 210-269 (288) alignment 
Range on Protein: 406-463
Range on HMM: 210-269/288.0
VLDNFWAnpdNARKDVIIHCHYGFNRSGFMACSYLV-----KRRGFGAREALHAFRKARPPGI
 .... |   .  . |..||. | .|.| ... .|.     |..|. . ||.. .|. ||  .
lvrkala...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmv
0047943 (Phosphotyrosine protein) phosphatases II 409-465 2.4e-09 32.5 In-house 197-257 (273) alignment 
Range on Protein: 409-465
Range on HMM: 197-257/273.0
NFWAN-PDNarKDVIIHCHYGFNRSGFMACSYLV-----KRRGFGAREALHAFRKARPPGIKH
.. .. |.|  . |..||. | .|.| ... .|.     |..|. . ||.. .|. || ..  
kalealpsn..gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqt
subfamily_DSP12_pd Subfamily DSP12 410-468 9.8e-07 23.3 In-house 74-132 (155) alignment 
Range on Protein: 410-468
Range on HMM: 74-132/155.0
FWANPDNARKDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRKARPPGIKHEHF
|  .  . .. |..||..|  ||  .   ||.|. ..   .||.. ....|     | |
FieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegF
0045098 (Phosphotyrosine protein) phosphatases II 412-468 9.8e-11 37.0 In-house 194-260 (278) alignment 
Range on Protein: 412-468
Range on HMM: 194-260/278.0
AN------PDNARKDVIIHCHYGFNRSGFMACSYLVKRR---GFGAREALHAFRKARPP-GIKHEHF
         ..  . |..||..| .|.| ... ||....   |. . ||.. .|. ||   . ....
slllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleq
subfamily_PTPDC1_pd Subfamily PTPDC1 419-465 3.9e-08 28.0 In-house 115-161 (182) alignment 
Range on Protein: 419-465
Range on HMM: 115-161/182.0
KDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRKARPPGIKH
. | .||| |  | | . ..|||  . . | .|..  |. ||  |. 
gkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqt
subfamily_DSP3_pd Subfamily DSP3 419-459 1e-06 22.5 In-house 98-138 (162) alignment 
Range on Protein: 419-459
Range on HMM: 98-138/162.0
KDVIIHCHYGFNRSGFMACSYLVKRRGFGAREALHAFRKAR
  |..||. |. ||  ..  ||. || . . ||... || |
gkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkR