Gene SSH-2 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily Slingshot
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP020_AA protein Get Run
MbreP020_AA_342-477 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
DEK_C DEK C terminal domain 291-337 1.8e-15 46.0 Pfam-A 5-51 (54) alignment 
Range on Protein: 291-337
Range on HMM: 5-51/54.0
LLPEIKKIIAASDLDTLTSKEVRLALELKFGRTLKQFKGYIDEQMIV
.  |...| . .||.|.|.|.|| .|| ..|  |...| .|....  
ikeevreiLkeaDLetvTkkqvrkeLearlgvdLserKafIkdliee
subfamily_Slingshot_pd Subfamily Slingshot 327-477 1.1e-74 243.4 In-house 1-151 (169) alignment 
Range on Protein: 327-477
Range on HMM: 1-151/169.0
FKGYIDEQMIVAFGQMAPPSPISDLIFLGTEWNACNLEELRENGCSHILNVTEEVPSYFEQDFEYLRISLPDEETENLLQHWNRTFDFIELARANDSRVL
.| .||..|.| .||.. .| | | ..||.||||.|||||.|||...|||||.|. ..|...||||.|.. |||...||..||.|..||| |....|.||
ykefidnemlvilgqldsaskifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvl

VHCKMGVSRSASTVMAYLMRFHGWTRDHTFEYVRERRNVVQPNKGFWEQLK
||||||||||||||.|| |. .|.. ....|||.|||.|..|||||..||.
vhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqle
0044763 (Phosphotyrosine protein) phosphatases II 335-477 7e-40 131.9 In-house 13-164 (178) alignment 
Range on Protein: 335-477
Range on HMM: 13-164/178.0
MIVAFGQMAPPSPISDLIFLGTEWNACNLEELRENGCSHILNVTEEVPSYFEQD---------FEYLRISLPDEETENLLQHWNRTFDFIELAR-ANDSR
. .  ... ..| | . ..||. ..|..|| |.|.|..||.|.|||.. .|...         ..||.| .||  . .||.|. ....||| |.  ....
eglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggp

VLVHCKMGVSRSASTVMAYLMRFHGWTRDHTFEYVRERRNvVQPNKGFWEQLK
|||||..||.||.. |.||||. .|.. .. .|.|||||. ..|| |...||.
vlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLy
subfamily_LRR-DSP_pd Subfamily LRR-DSP 340-477 7.2e-29 94.7 In-house 115-252 (263) alignment 
Range on Protein: 340-477
Range on HMM: 115-252/263.0
GQMAPPSPISDLIFLGTEWNACNLEELRENGCSHILNVTEEVPSYFEQDFEYLRI-SLPDEETENLLQHWNRTFDFIELARANdSRVLVHCKMGVSRSAS
 . . |. | | .|||.   | |   |...| .|||    ..  .| . | || |  . | .  .. ||...|  |||  | .   |||||. |||||..
lvssvPdeiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkk.GGvlvhcraGvsrsst

TVMAYLMRFHGWTRDHTFEYVRERRNVVQPNKGFWEQLK
 |..|||. .  .  .... | ..|. .|||.|| .|||
lvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlk
0045098 (Phosphotyrosine protein) phosphatases II 341-476 8.2e-27 89.7 In-house 18-264 (278) alignment 
Range on Protein: 341-476
Range on HMM: 18-264/278.0
QMAPPSPISDLIFLGTEW-----------------------------------------NACNLEELRENGCSHILNVT---------------------
 . .|| |.. ..||  .                                          | ... |.|.|...|...|                     
llgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslt

-------------------------------EEVPSYFEQDFEYLRISLPDEETENLLQHWNRTFDFIELARA--------------NDSRVLVHCKMGV
                               |. .|.. . . || .   .  ....|... . ..||. |..              .. .|||||..||
ygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGv

SRSASTVMAYLMRFH---GWTRDHTFEYVRERRNV-VQPNKGFWEQL
.|..  |.||||. .   |.. .......|..|.  ...|......|
gRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrfl
subfamily_DSP10_pd Subfamily DSP10 342-476 4e-37 121.5 In-house 11-146 (159) alignment 
Range on Protein: 342-476
Range on HMM: 11-146/159.0
MAPPSPISDLIFLGTEWNACNLEELRENGCSHILNVTEEVPSYFEQ-DFEYLRISLPDEETENLLQHWNRTFDFIELARANDSRVLVHCKMGVSRSASTV
 || |..   .||| | .| .|. |.. . ...|||| .|| .||. ...| || . | ...|| |...  ..||| || ..|||||||. |.||||. |
tapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvv

MAYLMRFHGWTRDHTFEYVRERRNVVQPNKGFWEQL
.||||.  . .  . ...|.|.| .. || .|  ||
iaYlmkhlnlslndaykfvkekrpiisPnLnfmGqL
0041856 (Phosphotyrosine protein) phosphatases II 344-476 1.7e-32 107.8 In-house 18-165 (182) alignment 
Range on Protein: 344-476
Range on HMM: 18-165/182.0
PPSPISDLIFLGTEWN--------------ACNLEELRENGCSHILNVTeeVPSYFEQ-----DFEYLRISLPDEETENllqhWNRTFDFIELARANDSR
... | . ..||  ..              |..|. |.|.|...|.|.|   . |. .      ..||... || .. .    .. ..|||| ..... .
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggp

VLVHCKMGVSRSASTVMAYLMRFHGWTRDHTFEYVRERRN--VVQPNKGFWEQL
|||||..||.|... |.||||. .|.. ......||.||.  |..|| .|..||
vlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflql
0049260 (Phosphotyrosine protein) phosphatases II 344-477 5.6e-30 99.4 In-house 7-143 (152) alignment 
Range on Protein: 344-477
Range on HMM: 7-143/152.0
PPSPISDLIFLGTEWNACNLEELRENGCSHILNVTEEVPS---YFEQDFEYLRISLPDEETENLLQHWNRTFDFIEL-ARANDSRVLVHCKMGVSRSAST
.| ..   ...| .. | ... |.|.|...|...||...    ..|| ..||..  ||  . .| |.    ..|||  |. .. .|||||. ||.|..  
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtl

VMAYLMRfHGWTRDHTFEYVRERRNVVQPNKGFWEQLK
|.||||. .|.. ......|||.|... ||.|....|.
vaaylml.lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_DSP1_pd Subfamily DSP1 345-476 3.2e-41 135.1 In-house 17-149 (163) alignment 
Range on Protein: 345-476
Range on HMM: 17-149/163.0
PS-PISDLIFLGTEWNACNLEELRENGCSHILNVTEEVPSYFEQDFEYLRISLPDEETENLLQHWNRTFDFIELARANDSRVLVHCKMGVSRSASTVMAY
|.  | | ..||.| .| ||| |...| ..||||..|.. .||. ||| .. | |...... .....  .||. ..... .||.||..|.|||.. ..||
PvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclay

LMRFHGWTRDHTFEYVRERRNVVQPNKGFWEQL
||. . .. .  |..|..||....|| ||  ||
lmktkrvsleeafdfvkqrRsiisPnagFvlqL
subfamily_DSP6_pd Subfamily DSP6 345-476 1.3e-36 119.5 In-house 14-147 (158) alignment 
Range on Protein: 345-476
Range on HMM: 14-147/158.0
PSPISDLIFLGTEWNACNLEELRENGCSHILNVTEEVPSYFEQ--DFEYLRISLPDEETENLLQHWNRTFDFIELARANDSRVLVHCKMGVSRSASTVMA
|  | .|..||.. .|.||| |.. . ...||||...|. ||.  ...||.|.. |. ..|| ...  ...||. || ..| |||||  |.|||   ..|
pveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtla

YLMRFHGWTRDHTFEYVRERRNVVQPNKGFWEQL
|||. .  . ......|..|.  . ||  | .||
ylmkklalslndaydlvkkrksnisPnfnfmgql
0048076 (Phosphotyrosine protein) phosphatases II 345-476 5.5e-36 118.7 In-house 4-135 (145) alignment 
Range on Protein: 345-476
Range on HMM: 4-135/145.0
PSPISDLIFLGTEWNACNLEELRENGCSHILNVTEEVPSYFEQDFEYLRISLPDEETENLLQHWNRTFDFIELARANDSRVLVHCKMGVSRSASTVMAYL
|| | . ..||  ..|..||.|...|  ..||.| | . .......||....|| .. .||... . ..||| |.... .|||||..||.|... |.|||
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MRFHGWTRDHTFEYVRERRNVVQPNKGFWEQL
|. .|.. ....|.||..|  . || |....|
mlllgvsleealelvrsqrpgavpnpgqlrfl
PTPc_motif_SM00404 345-476 3.3e-35 116.0 In-house 2-134 (140) alignment 
Range on Protein: 345-476
Range on HMM: 2-134/140.0
PSPISDLIFLGTEWNACNLEELRENGCSHILNVTEEVPS-YFEQDFEYLRISLPDEETENLLQHWNRTFDFIELARANDSRVLVHCKMGVSRSASTVMAY
|| |.. ..||.. .| |.. | ..| .|..||||||.  . ...|..|.| | |.|...|....... |||| |...  .|||||..||||||. ..||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMRFHGWTRDHTFEYVRERRNVVQPNKGFWEQL
||| .... .. .|.|.|||. ..|| .|..||
lmryrqlslaeayefvkerRpiispnlnfvrqL
0048179 (Phosphotyrosine protein) phosphatases II 345-476 4.9e-35 115.7 In-house 4-137 (144) alignment 
Range on Protein: 345-476
Range on HMM: 4-137/144.0
PSPISDLIFLGTEWNACNLEELRENGCSHILNVTEEVPSYFEQDF--EYLRISLPDEETENLLQHWNRTFDFIELARANDSRVLVHCKMGVSRSASTVMA
|| | . ..||  . |..||.|...| ....|.||| . .|. ..  .||....|| .. .||........||| |.... .|||||..||.|... |.|
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YLMRFHGWTRDHTFEYVRERRNVVQPNKGFWEQL
|||. .|.. ......||.||  . || |....|
ylmkklglsleealalvrsrrpgavpnpgqlrfL
subfamily_DSP8_pd Subfamily DSP8 345-476 1.9e-30 99.5 In-house 15-147 (159) alignment 
Range on Protein: 345-476
Range on HMM: 15-147/159.0
PSPISDLIFLGTEWNACNLEELRENGCSHILNVTEEVPSY-FEQDFEYLRISLPDEETENLLQHWNRTFDFIELARANDSRVLVHCKMGVSRSASTVMAY
|  | . ..||.. .. . | |...| |..||. .. |.  . .. ..||. . |. .|.||. ......||. |.....|||||.  | ||||. ..||
ptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiay

LMRFHGWTRDHTFEYVRERRNVVQPNKGFWEQL
.|.    . |.....|.|.|....||  | .||
imktlemsldeayrfvkekrptispnlnflgqL
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 345-476 1.6e-28 93.0 In-house 7-140 (148) alignment 
Range on Protein: 345-476
Range on HMM: 7-140/148.0
PSPISD-LIFLGTEWNACNLEELRENGCSHILNVTEEVPSYFEQ-DFEYLRISLPDEETENLLQHWNRTFDFIELARANDSRVLVHCKMGVSRSASTVMA
|| | |  .|||    | .|| |.. | ..| | |.| .  ..|   ||| ..| |.. |.| . ..   .|.. |...  |||||..||||||.  ...
pseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalall

YLMRFHGWTRDHTFEYVRERRNVVQPNKGFWEQL
.|..|.  .  . ...|...|. |.||.|| .||
wlidfkrvslkealalvkskrryvdpnlgfLkqL
subfamily_DSP14_pd Subfamily DSP14 346-476 6.4e-38 124.2 In-house 8-137 (157) alignment 
Range on Protein: 346-476
Range on HMM: 8-137/157.0
SPISDLIFLGtEWNACNLEELRENGCSHILNVTEEVPSYFEQDFEYLRISLPDEETENLLQHWNRTFDFIELARANDSRVLVHCKMGVSRSASTVMAYLM
| | . .||.    | . |.|.... ..|.||| |.|.   .|.|.... . |.....| .|.... | || ..... ..||||..||||||| ..||||
sqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylm

RFHGWTRDHTFEYVRERRNVVQPNKGFWEQL
...  .  .....|...|....|| |||.||
kyeklsLreayklvksaRpiirPNvGFwkql
0049772 (Phosphotyrosine protein) phosphatases II 346-476 9.6e-33 109.6 In-house 155-266 (314) alignment 
Range on Protein: 346-476
Range on HMM: 155-266/314.0
SpisdliflgTEWNACNLEELRengcshilnvtEEV--PSYFEQD-FEYLRISLPDeETENLLQHWNRTFDFIELArANDSRVLVHCKMGVSRSAS-TVM
           |..|..||.|.           ||.  |..||.  ..|||| .|| ....||..... ..||| |  ....||||||.|..|...  |.
g.........neptaadlellk...........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvva

AYLMRFHGWTRDHTFEYVRERRNvVQPNKGFWEQL
||||. .|.. . ..|.||..|  ..||.||.|||
aylmkllgvsleealedvrlkRp.inpnpgfieql
0051082 (Phosphotyrosine protein) phosphatases II 346-476 9.7e-27 88.8 In-house 9-146 (151) alignment 
Range on Protein: 346-476
Range on HMM: 9-146/151.0
SPISDLIFLGTEWNACNLEELRENGCSHILNVTEEV-----PSYFEQ-DFEYLRISLPDEETENLLQHWNRTFDFIELARAN-DSRVLVHCKMGVSRSAS
| . . ....    | .||.|.|.|...|.|...|.     |.|... ..|.|.| ..|  . .| ....   .|.||.... .  |||||..|..|.. 
syvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGt

TVMAYLMRfHGWTRDHTFEYVRERRN-VVQPNKGFWEQL
 |..|||  .|.. . ..|..|..|  ||||| .|. ||
lvalylml.lgvsleealeeyrlkrpgvvqpnqqflfql
PTEN_1 347-477 2.1e-29 97.7 In-house 43-185 (196) alignment 
Range on Protein: 347-477
Range on HMM: 43-185/196.0
PISDLIFLGTEWNA-CNLEELRENGCSHILNVTEEVPS---------YFEQDFEYLRISLPDEETENLLQHWNRTFDFIELARANDS--RVLVHCKMGVS
 |..  ..| .  . ..|..| |.|  ...|..|| .          .|....|||... .|  . .| ...    .||| ......   |||||| |..
eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlg

RSASTVMAYLMRFHGWTRDHTFEYVRERRNVVQPNKGFWEQLK
||.  |.||||. ...| | ..|.|||.| .. || ...|.|.
RsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerll
subfamily_DSP19_pd Subfamily DSP19 348-477 3.3e-41 135.2 In-house 15-144 (152) alignment 
Range on Protein: 348-477
Range on HMM: 15-144/152.0
ISDLIFLGTEWNACNLEELRENGCSHILNVTEEVPSYFEQDFEYLRISLPDEETENLLQHWNRTFDFIELARANDSRVLVHCKMGVSRSASTVMAYLMRF
... ..||    | . |.|.|..  |||||. .||  | .||.|| |.. |.. ..||.......|||| || .| .|||||. ||||||| |.||||. 
veprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkk

HGWTRDHTFEYVRERRNVVQPNKGFWEQLK
.  .  ...|.||| |  ..||.||..|||
eelsleealelvrearpcikPneGFikqLk
subfamily_DSP12_pd Subfamily DSP12 348-477 9.4e-33 107.8 In-house 5-137 (155) alignment 
Range on Protein: 348-477
Range on HMM: 5-137/155.0
ISDLIFLGTEWNACNLEELRENGCSHILNVTEE-VPSYFEQ--DFEYLRISLPDEETENLLQHWNRTFDFIELARANDSRVLVHCKMGVSRSASTVMAYL
| . ..||.  .. . | |.| . .|.| |..| .|.. ..    ... | . ||..|..|.| ....|||| |....  |||||..|||||...|.|||
ilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYl

MRFHGWTRDHTFEYVRERRNVVQPNKGFWEQLK
|. ...  .. .. |.| .. ..||.|| ||||
mkkeklslekAlklvkekkpeiepNegFleQLk
subfamily_MKPLT_pd Subfamily MKPLT 348-476 1.2e-32 106.7 In-house 25-153 (164) alignment 
Range on Protein: 348-476
Range on HMM: 25-153/164.0
ISDLIFLGTEWNACNLEELRENGCSHILNVTEEVPSYFEQDFEYLRISLPDEETENLLQHWNRTFDFIELARANDSRVLVHCKMGVSRSASTVMAYLMRF
. | ..||   .| | . |..    ||.||..|  . | . .|||.... || .|.| .. .|. .|.  |  .  |||||| .|.|||.|. .|.|...
ledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiks

HGWTRDHTFEYVRERRNVVQPNKGFWEQL
.||| ....||..||| .|.||.||  ||
kgwtlkeayeylkerrsivapnrGflkql
subfamily_MKPLV_pd Subfamily MKPLV 348-476 1.2e-32 106.7 In-house 25-153 (164) alignment 
Range on Protein: 348-476
Range on HMM: 25-153/164.0
ISDLIFLGTEWNACNLEELRENGCSHILNVTEEVPSYFEQDFEYLRISLPDEETENLLQHWNRTFDFIELARANDSRVLVHCKMGVSRSASTVMAYLMRF
. | ..||   .| | . |..    ||.||..|  . | . .|||.... || .|.| .. .|. .|.  |  .  |||||| .|.|||.|. .|.|...
ledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiks

HGWTRDHTFEYVRERRNVVQPNKGFWEQL
.||| ....||..||| .|.||.||  ||
kgwtlkeayeylkerrsivapnrGflkql
0046846 (Phosphotyrosine protein) phosphatases II 348-476 4e-29 97.0 In-house 15-165 (176) alignment 
Range on Protein: 348-476
Range on HMM: 15-165/176.0
ISDLIFLGTEW----------NACNLEELRENGCSHILNVTEEV-----------PSYFEQDFEYLRISLPDEETENLlQHWNRTFDFIELARANDSRVL
| . ..||  .           | .||.|.|.|.....|.||||           | . . ...||..  ||  . .| ... . ..||. |. .. .||
inanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeggpvl

VHCKMGVSRSASTVMAYLMRF-HGWTRDHTFEYVRERRN-VVQPNKGFWEQL
|||..|..|..  |.|||..  .|.. ......|||.|   . .. .....|
VHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrfl
0043147 (Phosphotyrosine protein) phosphatases II 349-477 9.6e-32 105.4 In-house 23-154 (172) alignment 
Range on Protein: 349-477
Range on HMM: 23-154/172.0
SDLIFLGTEWNACNLEELRENGCSHILNVTEE---VPSYFEQDFEYLRISLPDEETEnLLQHWNRTFDFIEL--ARANDSRVLVHCKMGVSRSASTVMAY
 .  ... .  | ... |.|.|..||.|.||.    . .......||... ||  .  ||... ....||.   |. .. .|||||..||.|..  |.||
iatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaay

LMRfHGWTRDHTFEYVRERRNVVQPNKGFWEQLK
||. .|.. ......|||.|. . .|.... .|.
lml.lglsleeavalvrekRpgavqnpsqyrfly
0036282 (Phosphotyrosine protein) phosphatases II 349-476 3.9e-25 84.0 In-house 16-162 (174) alignment 
Range on Protein: 349-476
Range on HMM: 16-162/174.0
SDLIFLGTEWNAcNLEELRENGCSHILNVTEEV---------------PSYFEQDFEYLRISLPDEETENLLQhWNRTFDFIELARAN--DSRVLVHCKM
.. ...|    | ..|.|.|.|........||.                .. . ...||..  || .. .| . . . ..|.| |...  .  |||||..
tprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsa

GVSRSASTVMAYLMRFHGW-TRDHTFEYVRERR---NVVQPNKGFWEQL
||.|..  |.||||  ... . .. ...|||.|     . .. .....|
GvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrfl
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 349-476 3.5e-22 72.4 In-house 7-145 (154) alignment 
Range on Protein: 349-476
Range on HMM: 7-145/154.0
SDLIFLGTEWNACNLEELRENGCSHILNVTEEVPSYFEQD---------FEYLRISLPDEETENLLQHWNRTFDFIELAR--ANDSRVLVHCKMGVSRSA
.  .....   | |  .|...   .||||   ..  | ..         .|||.. | |.   ..... ...|.||. |    ....||||.. ||||||
aiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsa

STVMAYLMRFHGWTRDHTFEYVRERRNVVQPNKGFWEQL
. ...|||     .   ..| ... | ...||.|| .||
allisylmdklkislslalellkdsryiikPnqGflkql
subfamily_DSP3_pd Subfamily DSP3 350-476 8.2e-29 94.3 In-house 16-150 (162) alignment 
Range on Protein: 350-476
Range on HMM: 16-150/162.0
DLIFLGTEWNACNLEELRENGCSHILNVTEE----V---PSYFE-QDFEYLRISLPDEETENLLQHWNRTFDFIELARAN-DSRVLVHCKMGVSRSASTV
. ...| |  | . ..|.. |  |.|| .|     |   .....  ...|| . . |  . .| ........||. | .. ...|||||..||||||  |
pklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlv

MAYLMRFHGWTRDHTFEYVRERRNVvQPNKGFWEQL
.|||| ..  |  .  . ||..|.. .||.|| .||
layLmirrkmtlveairtvrkkRei.lPneGFlkqL
0042113 (Phosphotyrosine protein) phosphatases II 350-476 5.1e-23 77.2 In-house 52-235 (245) alignment 
Range on Protein: 350-476
Range on HMM: 52-235/245.0
DLIFLGTEWNACNLE----ELRENGCSHILNVTEEV----------------------------------------------PSYFEQDFEYLRISLPDE
. ....    . ..|     |.|.|...|...|||.                                               ..  ... |.... || 
pkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdh

ETENLLQHWNRTFDFIELARA--NDSRVLVHCKMGVSRSASTVMAYLM-----RFHGWTRDHTFEYVRERRNVVQPNKGFWEQL
 . .||..  . ..|.. |.|  .. .|||||..||.|..  ..||||     . .|.. .......|..|  . .. .....|
gvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrfl
subfamily_STYXL1_pd Subfamily STYXL1 350-477 4.4e-21 68.7 In-house 17-147 (157) alignment 
Range on Protein: 350-477
Range on HMM: 17-147/157.0
DLIFLGTEWNACNLEELRENGCSHILNVTEEVPSYFEQDF---EYLRISLPDEETENLLQHWNRTFDFIELARANDSRVLVHCKMGVSRSASTVMAYLMR
. ..||.. .|.| .  ..      .||. .    .. .    . |.|.. ||.  .||.. ..  .|||  . ... |||  . |.||||. ..|||| 
gklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmy

FHGWTRDHTFEYVRERRNVVQPNKGFWEQLK
 . .|  ....|... .. |.||..| |||.
skkitlkkaykylkkCkenvkPnrafveqls
DSPc Dual specificity phosphatase, catalytic domain 352-476 5.1e-32 105.5 Pfam-A 1-127 (133) alignment 
Range on Protein: 352-476
Range on HMM: 1-127/133.0
IFLGTEWNACnLEELRENGCSHILNVTEEVPS---YFEQDFEYLRISLPDEETENLLQHWNRTFDFIELARANDSRVLVHCKMGVSRSASTVMAYLMRFH
..||.. .|  |. | ..| ....|||.|||    . ....||||| . ||..... .. ... .||| |...  .|||||..|.||||. ..||||. .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GWTRDHTFEYVRERRNVVQPNKGFWEQL
... .. .|.|.|||. . || ||. ||
nlslneAyefvkerrskispnagflrqL
DSPc Dual specificity phosphatase, catalytic domain 352-476 5.1e-32 105.5 In-house 1-127 (133) alignment 
Range on Protein: 352-476
Range on HMM: 1-127/133.0
IFLGTEWNACnLEELRENGCSHILNVTEEVPS---YFEQDFEYLRISLPDEETENLLQHWNRTFDFIELARANDSRVLVHCKMGVSRSASTVMAYLMRFH
..||.. .|  |. | ..| ....|||.|||    . ....||||| . ||..... .. ... .||| |...  .|||||..|.||||. ..||||. .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GWTRDHTFEYVRERRNVVQPNKGFWEQL
... .. .|.|.|||. . || ||. ||
nlslneAyefvkerrskispnagflrqL
subfamily_DSP15_pd Subfamily DSP15 352-477 7.1e-27 88.4 In-house 9-133 (151) alignment 
Range on Protein: 352-477
Range on HMM: 9-133/151.0
IFLGTEWNACNLEELRENGCSHILNVTEEvPSYFEQDFEYLRISLPDEETENLLQHWNRTFDFIELARANDSRVLVHCKMGVSRSASTVMAYLMRFHGWT
..||   .. . | |.|.  .|||.| .. .  . .|.||. |.. |    .| .. . . .||  .| ..  ||||| .|||||.  |.||||      
lylgnfrdskdeelLkeknithilsvhdn.akkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvteln

RDHTFEYVRERRNVVQPNKGFWEQLK
   ..| ....| | .|| || .|||
wrdalevikaaRsvanPnfGfkrqlk
subfamily_STYX_pd Subfamily STYX 353-477 8.5e-24 77.5 In-house 20-151 (166) alignment 
Range on Protein: 353-477
Range on HMM: 20-151/166.0
FLGTEWNA--CNLEELRENGCSHILNVTEE-----VPSYFEQDFEYLRISLPDEETENLLQHWNRTFDFIELARANDSRVLVHCKMGVSRSASTVMAYLM
|||    |    || |...| .||. . ..     .   |...| || . . |. .||....  .. .||. .  .  .|||| . |.||||. |.||.|
flgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayim

RFHGWTRDHTFEYVRERRNVVQPNKGFWEQLK
  .|    ..| ||.|||  ..||.|| .|||
etyglkyreafayvqerrfcinpnegfvsqlk
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 353-475 1.3e-15 50.8 In-house 7-133 (145) alignment 
Range on Protein: 353-475
Range on HMM: 7-133/145.0
FLGTEWNACNLEELRENGCSHILNVT--EEV--PSYFEQDFEYLRISLPDEETENLLQHWNRTFDFIELARANDSRVLVHCKMGVSRSASTVMAYLMRFH
. |.  .| ..  |.| | | |.|..  . |   .   ...| | |.  | |. .| ||..   |||.  . . . |.|||  ||||| .  .|.||.. 
yvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkyc

GWTRDHTFEYVRERRNVVQPNKGFWEQ
. |  ..   || .|    ||  |  .
nmtlseaarqvrsnrllaypnvtflkn
0051429 (Phosphotyrosine protein) phosphatases II 356-476 3.7e-20 68.2 In-house 28-217 (272) alignment 
Range on Protein: 356-476
Range on HMM: 28-217/272.0
TEW---NACNLEELRENGCSHILNVTEEVPSYFEQ------DFEYLRISLPDEETENLLQHW--------------------------------------
  .   .| ... |.|.|...|.....|.   ...      ...||.....|....  |...                                      
ggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhy

----------NRTFDFIELARAnDSRVLVHCKMGVSRSASTVMAYLMRfHGWT--------------RDHTFEYVRERRNVVQPNKGFWEQL
          .   ...|| .. . .|||||. |..|..  |...|.  .|..               ... |..|..|  . .. .....|
tdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylfl
0038934 (Phosphotyrosine protein) phosphatases II 359-476 2.7e-19 65.0 In-house 45-169 (194) alignment 
Range on Protein: 359-476
Range on HMM: 45-169/194.0
NACNLEELRENGCSHILNVTEEVPSYFEQDF-----EYLRISLPDEE---TENLLQHWNRTFDFIElARANDSRVLVHCKMGVSRSASTVMAYLMRFHGW
. ... .|.  .. .....|.. . |  ..|     |||..  ||     . ..|... .  |..  .. ..  |.||||.|..|..  | |||.  .|.
dlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefl.nedpggvvaVHCkaGlgRtGtlvaaYLiyrlgm

TRDHTFEYVRERRNVVQPNKGFWEQL
. .   ...||.|. . || ...|.|
saeeAialfrekRpgaipnqdyleal
0037934 (Phosphotyrosine protein) phosphatases II 360-476 6.6e-26 86.8 In-house 62-234 (243) alignment 
Range on Protein: 360-476
Range on HMM: 62-234/243.0
ACNLEELRENGCSHILNVTEEV---------------------------------------------PSYFEQDFEYLRISLPD----EETENLLQHWNR
| ... | |.|...|...||.|                                             . .. ... |.... ||    ...|.||.... 
asfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldflde

TFDFIEL-----ARANDSRVLVHCKMGVSRSASTVMAYLMRFH-GWTRDHTFEYVRERRNV-VQPNKGFWEQL
. .|||      |. ....|||||..||.|..  ..||||  . |.. .......||.|.  . .. .....|
vrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrfl
0040439 (Phosphotyrosine protein) phosphatases II 360-476 1.5e-25 85.7 In-house 68-238 (249) alignment 
Range on Protein: 360-476
Range on HMM: 68-238/249.0
ACNLEELRENGCSHILNVTEEVPS-------------------------------------------YFEQDFEYLRISLPDEETENLLQHWNRTFDFIE
. ... |.|.|...|...|..|.                                            |. .....| |  .|    .. .. . ..||||
edfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfie

LARA------NDSRVLVHCKMGVSRSASTVMAYLM-----RFHGWTRDHTFEYVRERRNVVQPNKGFWEQL
..|       ....|||||..||.|..  ..||||     . .|.. .......|..|. . .| .....|
avrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrfl
0045450 (Phosphotyrosine protein) phosphatases II 364-476 9e-24 80.2 In-house 125-296 (307) alignment 
Range on Protein: 364-476
Range on HMM: 125-296/307.0
EELRENGCSHILNVTEEVPS----------------------------YFEQDFEYLRISLPDE-----------------ETENLLQHWNRTFDFIELA
. |.|.|...|...||.|.                             . .... .... . |                     .. .... ..||||..
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

RA------NDSRVLVHCKMGVSRSASTVMAYLMRFHG--------WTRDHTFEYVRERRNVVQPNKGFWEQL
|.      ....|||||..||.|... ..||||  ..        .. .......||.|  . .| .....|
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfl
0040438 (Phosphotyrosine protein) phosphatases II 364-476 1.5e-21 72.4 In-house 104-268 (317) alignment 
Range on Protein: 364-476
Range on HMM: 104-268/317.0
EELRENGCSHILNVTEEVPSY---------------------------FEQDFEYLRISLPDE----------------ETENLLQHWNRTFDFIELARA
. . |.|...|...||...                              ......... . |                    .. ....  .||.|..|.
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

N----DSRVLVHCKMGVSRSASTVMAYLM-----RFHGWTRDHTFEYVRERRNVVQPNKGFWEQL
.    .. |||||..||.|... ..||||     . .|.. .......||.|. . .. .....|
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrfl
0039614 (Phosphotyrosine protein) phosphatases II 364-476 4.6e-20 67.7 In-house 119-281 (297) alignment 
Range on Protein: 364-476
Range on HMM: 119-281/297.0
EELRENGCSHILNVTEEVPS-------------------------YFEQDFE-----------------YLRISLPDEETENLLQHWNRTFDFIELARA-
. ..|.|...|...|..|.                          . ....                  .. .. ||  . ..|..  . ..... |.| 
rmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealae

--NDSRVLVHCKMGVSRSASTVMAYLM-----RFHGWTRDHTFEYVRERRNVVQPNKGFWEQL
  .. .|||||..||.|... ..||||     . .|.. .......||.|. . .. .....|
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrfl
0043336 (Phosphotyrosine protein) phosphatases II 365-476 1.2e-16 56.5 In-house 107-269 (278) alignment 
Range on Protein: 365-476
Range on HMM: 107-269/278.0
ELRENGCSHILNVTEEVP---------------------------------------------SYFEQDFEYLRISLPDEETE-NLLQHWNRTFDFIELA
 ..|.|...|...||.|                                              ..  .   |  .. || ..  .| ....   ...|  
mvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal

RANDSRVLVHCKMGVSRSASTVMAYLM-----RFHGWTRDHTFEYVRERRNVVQPNKGFWEQL
. ... |||||. ||.|..  ...||.     . .|.. .......||.|    ..  ....|
edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrfl
0036941 (Phosphotyrosine protein) phosphatases II 366-476 1e-18 63.1 In-house 98-269 (297) alignment 
Range on Protein: 366-476
Range on HMM: 98-269/297.0
LRENGCSHILNVTEEVPSYF-------------------------------EQDFEYLRISLPD----------------EETENLLQHWNRTFDFIELA
. |.....|...||.|.  .                               ..|. .  . . |                    .. ....  .|||||.
vweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielv

RA------NDSRVLVHCKMGVSRSASTVMAYLM--------RFHGWTRDHTFEYVRERRNVVQPNKGFWEQL
|       ....|||||..||.||.. ..|.||        . .|..   .. ..||.|. . .. .....|
rkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfl
0047943 (Phosphotyrosine protein) phosphatases II 366-475 4e-13 44.9 In-house 97-263 (273) alignment 
Range on Protein: 366-475
Range on HMM: 97-263/273.0
LRENGCSHILNVTEEVPS-------YFEQD-------FEYLRISLPDEE--------------------------------TENLLQHWNRTFDFIELAR
. |.....|  .||.|         |. ..       .. ... | .||                                  .  ....  ..||||.|
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

A------NDSRVLVHCKMGVSRSASTVMAYLM-----RFHGWTRDHTFEYVRERRNVVQPNKGFWEQ
       ... |.|||. ||.|... ....|.     . .|.. . .. ..|..|  . ..  ....
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrf
0050432 (Phosphotyrosine protein) phosphatases II 366-466 6.7e-11 37.5 In-house 128-281 (308) alignment 
Range on Protein: 366-466
Range on HMM: 128-281/308.0
LRENGCSHILNVTEEVPSYFEQDFEYLRISLP----------------------------------------------DEETENLLQHWNRTFDFIELAR
. |.....|  .|..|    |. ..|   .|                                               . .  .  ....  .||.||.|
vweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvr

AN--DSRVLVHCKMGVSRSASTVMAYLM-----RFHGWTRDHTFEYVRERRNVV
    .. ..|||. ||.|..  ....|.     . .|..  ... ..||.|. .
kslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgm
0051299 (Phosphotyrosine protein) phosphatases II 367-467 1.5e-11 39.8 In-house 113-269 (288) alignment 
Range on Protein: 367-467
Range on HMM: 113-269/288.0
RENGCSHILNVTEEVPS-----------------------------------------------YFEQDFEYLRISLPDEETENLLQHWNRTFDFIELAR
 |.....|  .|..|                                                 . .. ...  .  ..    .  ....  .||..|.|
weqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvr

AN----DSRVLVHCKMGVSRSASTVMAYLM-----RFHGWTRDHTFEYVRERRNVVQ
      .. |.|||. ||.|..  ....|.     . .|..  ......||.|. . 
kalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmv
0046845 (Phosphotyrosine protein) phosphatases II 368-464 3.9e-10 35.1 In-house 99-254 (284) alignment 
Range on Protein: 368-464
Range on HMM: 99-254/284.0
ENGCSHILNVTEEV------------------------------------------------PSYFEQDFEYLRISLPDEETENLLQHWNRTFDFIELAR
|.....|  .||.|                                                ...  .   .  .| ||  .   ...  . ..... ..
eqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrell

AN---DSRVLVHCKMGVSRSASTVMAYLMRFH--------GWTRDHTFEYVRERRN
 |   .. ..|||. ||.|..  ....|.  .        |..  ... ..||.|.
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRp
subfamily_PTPMT1_pd Subfamily PTPMT1 373-476 1.1e-16 55.8 In-house 61-161 (171) alignment 
Range on Protein: 373-476
Range on HMM: 61-161/171.0
HILNVTEEvpsYFEQDFEYLRISLPDEETENLLQHWNRTFDFIELARANDSRVLVHCKMGVSRSASTVMAYLMRFHGWTRDHTFEYVRERRNVVQPNKGF
.. | |||   . ... |.|... .|   .  |.. ... .|||  . . .|| |||| | .|||. | .|||  . .. ..  ......|. .. .|  
alanstee...wkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkq

WEQL
|..|
wkal
subfamily_MSG5_pd Subfamily MSG5 376-476 3.7e-14 46.2 In-house 53-153 (165) alignment 
Range on Protein: 376-476
Range on HMM: 53-153/165.0
NVTEEVPSYFE--QDFEYLRISLpdEETENLLQHWNRTFDFIELARANDSRVLVHCKMGVSRSASTVMAYLMRFHGWTRDHTFEYVRERRNVVQPNKGFW
||..|..         .|  |    | . .. .  .|    |  |...  ..||||. |.||||| ..||.|.... .  .... .. . . ..|. |. 
nvakeindlellvpavkyyhiew..ehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsigli

EQL
 ||
fql
subfamily_Laforin_pd Subfamily Laforin 384-465 7.1e-08 25.5 In-house 72-153 (183) alignment 
Range on Protein: 384-465
Range on HMM: 72-153/183.0
YFEQDFEYLRISLPDEETENLLQHWNRTFDFIELARANDSRVLVHCKMGVSRSASTVMAYLMRFHGWTRDHTFEYVRERRNV
| |. . |. . ..|  ||. ..   ..  ..     .  .| |||. || ||.. |  .|.   ||.  .   ..  .| |
ykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpv
0048567 (Phosphotyrosine protein) phosphatases II 405-463 7.1e-08 27.0 In-house 39-118 (157) alignment 
Range on Protein: 405-463
Range on HMM: 39-118/157.0
LQHWNR------------------TFDFIELARANDSRVLVHCKMGV---SRSASTVMAYLMRFHGWTRDHTFEYVRERR
|....                     .|... . .. .. ||||.|    .|.|  . .||.  .|.| . .....|  |
lvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivr