Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| 0040695 | (Phosphotyrosine protein) phosphatases II | 106-497 | 2.7e-30 | 99.4 | In-house | 15-316 (388) | alignment | ||
Range on Protein: 106-497
Range on HMM: 15-316/388.0
ARVVRTLLERDYHVRAIDNRNGRLCSHYPFELYileghkgsdelinnadeldmVFS-----GESQYARCRRRFVVPVILI----DSMNICRSATLSRsge
.. |. |..|. | |.|. ||..|| |. | . ..||.|... .||.. . . ..||...
relkrlglgldlwrisivNenyelcpsYPallv....................VPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplv...
ivyrqsctavskvygalwedasteaaaharqnnelipatsdsvymaaatatdmATAQERMSALERCRRADVELLRHLRVQFIADLMiekKKVKYGLHVSS
.. |. . |. ..|...||. |.. .| ||. .|... . . .
.....................................................glllsrsledeklleailkllpnlskllivdlr...pklnalanral
SEKADTSGMYDSFDLVALPYPGVEWFNSmreqhynpfkivrslpvlvpvsfltiP---------------------Cmactffnwshpevsvdltipkqa
... . ..| ...|. |..|.......
gggvenedaypnaeliflnipnihvvre..........................slqklldaclnvpdslnllslle.......................
ralvdtdwsNYKKWDLVTLTKNYLKLMLAHIRtnkeDADQGLLVHCISGWDRTPLFTSLLRLSLWADgliHQSLSAEEMLyltVGYDWLLFGHLLPSRLN
... .||. |. ....|.. ... . . ..||||..|||||....||..|.|... ...| .| . ..||.||| ...||.
.........esgwldliklilelavlivklld....lgnssvlvhcsdgwdrtsqlssLaqllldPy...YRTleGFqvL...iekeWlsfghkfadRlg
KGEE---------------------------IFLFCFDVLQYLDSDEFS
.|. .| |.. .| .| .|
hleseidskefsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlys
|
|||||||||
| subfamily_MTMR14_pd | Subfamily MTMR14 | 107-498 | 6.6e-162 | 530.3 | In-house | 1-352 (357) | alignment | ||
Range on Protein: 107-498
Range on HMM: 1-352/357.0
RVVRTLLERDYHVRAIDNRNGRLCSHYPFELYIL-----EGHKGSDELINNA---DELDMVFSgESQYARCRRRFVVPVILIDSMNICRSATLSRSGEIV
..|..||.|||....|||.||.|||.||..|.|| ||..|..||...| ..|..... ...|||||.||||||||.|..|||||||||...||.
kkveellkrdyslsvidntnGelcsrypvkllileyelgegsegekelvesaydvqrlrellt.kakyarcrerfvvpvilldgknicrsatlsvaaeiy
YRqsctavskvYGALWEDASTEAAAHARQNNELIPATSDsvymaaatatdmatAQERMSALERCRRADVELLRHLRVQFIADLMIEKKKVKYGLHVSSSE
.| .|. ......|.|.......||| |..| ..|....|.|.|..|..||..|.|..|.|||.|||||||||.|||||
gr.........sGlnylasggeeadadkedeelitaked..............qaeeqalldrvrksdikllktlkvklivdlmvekkkvkyglavssse
KADTSGMYDSFDLVALPYPGVEWFNSMREQHYnpfkivrslpvlvpvsfltipCMACTFFNWSHPEVSVDLTIPKQARALVDTDWSNYKKWDLVTLTKNY
|||.. .|..|.|..|||||||.|...|...| .....|.||...||...|.||....| ||.|||.|||||||.||.||
kadkekrykdftllslPyPGveffkkfrdnky.....................saknlfynWkqdevdaelniPdklaasvdidwseykkWdlvaltqny
LKLMLAHIrtnKEDADQGLLVHCISGWDRTPLFTSLLRLSLWADGLIHQSLSAEEMLYLTVGYDWLLFGHLLPSRLNKGEEIFLFCFDVLQYLDSDEFSL
|||.|... |||.|.||||||||||||||||.|||||||||||||||||||.|.|||||.|||.|||| ||.||.|||||..||||||....|.|||.
lklllkyv...kededsGllvhcisGWdrtPlfvsllrlslWadglihqslsaaellyltvaydWflfghqlpdrlkkgeeilffcfdvlkfitseefsi
|
|||||||||
| 0051082 | (Phosphotyrosine protein) phosphatases II | 265-438 | 1.3e-06 | 23.6 | In-house | 24-116 (151) | alignment | ||
Range on Protein: 265-438
Range on HMM: 24-116/151.0
ADVELLRHLRVQFIADLMIEKKKVKYGLHVSSSEkadtsgmydsfdlvalpypgvewfnsmreqhynpfkivrslpvlvpvsfltI-----PCMACTFFN
...|||..| .. | .|. |. .. . . . | |.. ....
dflellkelgiktivnlrseeergycpeylpelg...................................................ievlhipildwpdpg
wshpevsvdltipkqaralvdtdwsnykkwdlvtlTKNYLKLMLAHIRTNKEDADQGLLVHCISGWDRTPLFTSLLRLS
. ... .|. .. .. .. .|||| .|..|| .. |...
...................................lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml
|
|||||||||
| 0051429 | (Phosphotyrosine protein) phosphatases II | 374-442 | 1e-06 | 24.2 | In-house | 115-178 (272) | alignment | ||
Range on Protein: 374-442
Range on HMM: 115-178/272.0
QARALVDTDWSNYKKWDLVTLTKNYLKLMLAHIRTnkedaDQGLLVHCISGWDRTPLFTSLLRLSLWAD
.| . . | | ...|. .|..... .. .|||| .|.||| .. ||.| | .
sagearevmhlhytdwpdhgvpqeallellellld.....ggpvlvHCsaGkdRTGtvvallllllgvs
|
|||||||||
| 0049772 | (Phosphotyrosine protein) phosphatases II | 390-441 | 4.3e-06 | 22.2 | In-house | 190-241 (314) | alignment | ||
Range on Protein: 390-441
Range on HMM: 190-241/314.0
DLVTLTKNYLKLMLAHIRTNkeDADQGLLVHCISGWDRTP--LFTSLLRLSLWA
| . . .... .|..|... |.. .|||| .|..||. ... .| . |.
Dgsaplledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgv
|
|||||||||
| subfamily_Dicty-MTMR1-like_pd | Subfamily Dicty-MTMR1-like | 407-476 | 1e-06 | 20.2 | In-house | 215-278 (404) | alignment | ||
Range on Protein: 407-476
Range on HMM: 215-278/404.0
RTNKEDADQGLLVHCISGWDRTPLFTSLLrlSLWADGlIHQSLSAeemLYLTVGYDWLLFGHLLPSRLNK
. |. . ||||. |||||. .|| | .| .. ... . . .|| |||. .| ..
veliekekssvlvhcsdgwDrtsqlssls..qllldp.yyrtieg...FivliekewlsfGhkfaqRigq
|
|||||||||
| subfamily_MTMR1_pd | Subfamily MTMR1 | 409-479 | 1.6e-07 | 22.9 | In-house | 207-271 (389) | alignment | ||
Range on Protein: 409-479
Range on HMM: 207-271/389.0
NKEDADQGLLVHCISGWDRTPLFTSLLRLSLwaDGLiHQSLSAEEMLyltVGYDWLLFGHLLPSRLNKGEE
. | . |||| ||||| .||| | | | ..... |.| . .|| ||| . .|| .|..
kvetektsvlvhcsdGWDRtaqltsLamlll..Dsy.yRtieGfevl...iekeWlsfGHkfkeRlghgdk
|
|||||||||
| subfamily_MTMR3_pd | Subfamily MTMR3 | 410-492 | 1.1e-07 | 24.0 | In-house | 265-344 (442) | alignment | ||
Range on Protein: 410-492
Range on HMM: 265-344/442.0
KEDADQGLLVHCISGWDRTPLFTSLLRLSLwaDGlIHQSLSAEEMLyltVGYDWLLFGHLLPSRLNKGEEI---FLFCFDVLQYLD
. . .|||| |||||. ..| .| | | ...| ..| | .|| ||| . | ||.. | ||.||
vdkegrpvlvhCsdGWdrttqivalaklll..dp.yyrtleGfkvl...vereWldfGhkfadrcghgenvddanercPvflqwld
|
|||||||||
| Myotub-related | Myotubularin-like phosphatase domain | 412-477 | 7.6e-06 | 17.9 | Pfam-A | 229-288 (353) | alignment | ||
Range on Protein: 412-477
Range on HMM: 229-288/353.0
DADQGLLVHCISGWDRTPLFTSLLRLSLwaDGLiHQSLSAeemLYLTVGYDWLLFGHLLPSRLNKG
.. |||| ||||| .|| | | | ... . . | .|| ||| . .| .
seessVlvhcsdGwDrtaqvvslaqlll..dpy.yRtieG...fqvLvekeWlsfGhkFaeRvghl
|
|||||||||
| Myotub-related | Myotubularin-like phosphatase domain | 412-477 | 7.6e-06 | 17.9 | In-house | 229-288 (353) | alignment | ||
Range on Protein: 412-477
Range on HMM: 229-288/353.0
DADQGLLVHCISGWDRTPLFTSLLRLSLwaDGLiHQSLSAeemLYLTVGYDWLLFGHLLPSRLNKG
.. |||| ||||| .|| | | | ... . . | .|| ||| . .| .
seessVlvhcsdGwDrtaqvvslaqlll..dpy.yRtieG...fqvLvekeWlsfGhkFaeRvghl
|
|||||||||
| subfamily_Ank-MTMR1_pd | Subfamily Ank-MTMR1 | 415-475 | 4.8e-06 | 17.6 | In-house | 234-288 (405) | alignment | ||
Range on Protein: 415-475
Range on HMM: 234-288/405.0
QGLLVHCISGWDRTPLFTSLLRLSLwaDGLiHQSLSAeemLYLTVGYDWLLFGHLLPSRLN
. .|||| |||||| ||| .. | | .... . . . .|| ||| . ||
nsilvhcsdgwdrtpqitsltqill..dpy.yrtivg...fqvliekewlsfghkfslrlg
|
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