Gene MbreMyotubularin-Un-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily Myotubularin-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP024_AA protein Get Run
MbreP024_AA_1801-2213 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
UPF0061 Uncharacterized ACR, YdiU/UPF0061 family 123-471 6.6e-101 324.2 Pfam-A 54-394 (487) alignment 
Range on Protein: 123-471
Range on HMM: 54-394/487.0
DDFVAA-FAGNVPIPG-AEYAAHCYCGHQFGYFSGQLGDGAAMYLGEVVNERNERWELQFKGAGLTPFSRQADGRKVLRSSIREFLCSEAMHALNIPTTR
. .. | . ..  ..|   . |  | |.||| |..||||| .. ||.|    .|  . | |||||||.|| |||| ||||||||.| |||.| | |||||
naldeavqdqekllsGsisplatvysGfqfGsfaaqLGdGrgvllgdvrlkdkesldwqlkGaGltPysrfadGravLrssirevlasealhslGipttr

AGSLITSD-TRVVRDifytgslIQERATVITRLAPSFLRFGSFEVVKEKDpktmqegsspgQVELTKKLLDYLLAHHFADIWSQDSSPEDKFAEFLAEVT
| ||...| ... |.        || |.|. |.|||..|.| || .. .            ..|  ..|.|| . . ||..  | .  |||. ||. .| 
alslvllddskarre.......eqePaavlirfapshirlGnfellryrh...........dlekliqLsdyvieeyfaevkiqveddedkydeffrdvv

RRTAALVAQWQCVGWCHGVLNTDNMSVLGLTIDYGPFGFMEQYDPNFICNRSDDGGRYDYQSQPEICRWNLHRLADVLVPHLPLERARDIIDRhYTRTFE
 |.| ||||||.||..||||||||||.||||.|||||.|...|.|.||.| .| ..|| .. || ...|||.|||  | . |. |   . ..  | . | 
srvaklvaqWqavGfahGvlntdnmsilGltldyGPfafldkyepsfianhddtakrysfanqPavilWnLqrlakdLssllasealneaLek.ykkvfl

QAYMDGMRAKLGL-------LYPQGE-DQELIKALFTVMAKTSADFTNTFRLLSRFSIDD
  |.. |. .||.       |  | | .. |.. |. ..|..  |..|.|. |. . |.|
tryaelmsqrLGvdldlekrlseqkelcdvlveelldilaaekvdynnffiqLqnyfikd
UPF0061 Uncharacterized ACR, YdiU/UPF0061 family 542-629 1.3e-08 19.8 Pfam-A 407-487 (487) alignment 
Range on Protein: 542-629
Range on HMM: 407-487/487.0
EAMDEdnlTHWQLWFNKY-AARLQvdndtalkQDQMAR--DAVESRRRQVMDEHNPSFVLRNHVAQTAIAKAEQ-GDFSEVQRVLEELRRPF
| ...    ... .| ..   .||        || . .  .   . | ..... || .|||. |.....  .|. ||.|..... | || |.
eflns...aeteeafaagangklq........qdvlkevppeelaarasllkkanPllvlrswvleevvdasekdgdtsalkkLyeklrnpy
DENN DENN (AEX-3) domain 776-874 6e-17 51.4 Pfam-A 85-184 (185) alignment 
Range on Protein: 776-874
Range on HMM: 85-184/185.0
IDLLLQYLCPRDVVHIVLHAVLGRKIIVAGRHMTGVAHACAAIQQLMYPLSVWSVFIPNLPRHLVADVtPIPSQYLVGIHSDDLP--LADVGDGIVVQLD
.  |.. | .. |....  ..| |.||.  .... . ... |. .|.|||.   ..|| ||..|.  .   |  ...|..|. |     .  | ..| ||
leelfrcLsienvlqlfeavLlErriillSeklarLtsvaealvallyPlkWqhiyiPvlpaslldvl.eaPtPfiiGvesslleleekpledvvlvDld

D
.
t
Myotub-related Myotubularin-like phosphatase domain 1793-2151 7.7e-53 172.5 Pfam-A 19-350 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 1793-2151 7.7e-53 172.5 In-house 19-350 (353) alignment
subfamily_MTMR9_pd Subfamily MTMR9 1794-2207 8.6e-139 454.9 In-house 8-392 (393) alignment 
Range on Protein: 1794-2207
Range on HMM: 8-392/393.0
ATRQDTLFSDFDRMNILGVDHSsgVLPGWR-AVPNHGFRKVHSYPELFLLPDALDpSEEAGAMSAFVHN-RIPILQWTNATTGAAILmgaACAQASCSSv
||......|.|||.|......|  ....|| ...|..|....|||| ...|.|.| .||..|..||... |.|.|......|.|..|   ...|..|.| 
atiledgysafdrenefaklis..asdewRissvNknfkvcasypesvivPkaid.deelkasaafreggrfPvLsylhketkavll...rssqplcgs.

QafyralldlrvkpvrGQNAQGSQRLMDLKLQKLpvSKGSDAQPQIVVLGDNASTQDPQI-PGVTFIDVTMASRPLiTSVATIHEMAREL--SVLAAGLD
.               |........|..|.|.||  .||......... ..||......| . |.......|||.| .|||.|......|  .. .|||.
s...............gkrckedekllnlvlkkl..kkGlivdtrsksaaenarskgggietevkysqwkkasrsl.esvasiqdslaklleacsdagls

TGSFWRDLDKIGWLTQVADLLHWSNVIADLCTETHAVVVIAMEHGCDAAMQLTSLAMLQLDTHYRQLDAFMAhIINRVWIQHGHPFAARAGLVAAKPspR
|..|...|.|.|||.||||||....|.|....|..|.||...|.|.||..|.||||.|.||...|....|.| .|.|.|||.|||||.||  ||||.  .
tdkflsrleksgwlsqvadlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfea.liereWiqaGHPFasRaskvaake..t

SAELSGvaglpaPTFGLFLDCVYQMLSQFPAQFEFNAELLEAIFHHSYSARFGNFLCNDQAYRDRLGIDMD--DLFAFVmDAHAKTPQYANLMYSAcNAH
...|||      |.| ||||||||.||||||.||||.|||...|.||||..||.|||...|.|..|.....  .|...| ....|..|..|..|.| ||.
kkklsg......pvfllFLDcvyqilsqfpasFEFneelLillfehsyssqfgtflcdneaerkelklkkktvslwsyv.nrpeklkqflnplyea.nae

VLRTNAALPMMQLWRQVYMPT
|.....|.....||...|...
viwpsvapqslelWselylrw
subfamily_MTMR5_pd Subfamily MTMR5 1799-1884 1.8e-07 22.4 In-house 9-94 (483) alignment 
Range on Protein: 1799-1884
Range on HMM: 9-94/483.0
TLFSDFDRMNILGVDHSSGVLPgWRA-VPNHGFRKVHSYPELFLLPDALDPSEEAGAMSAFVHNRIPILQWTNATTGAAILMGAACA
. . |..|. .  . ..| . . .|    |. .   .||| |...|.... .. |     | .||.|.  | .. ..| .. ...  
ayvqdykRlGlgalngaskrgk.frisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfe
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 1802-2205 1.6e-41 134.8 In-house 23-400 (404) alignment 
Range on Protein: 1802-2205
Range on HMM: 23-400/404.0
SDFDRMNILGVDhssgvlpGWRA-VPNHGFRKVHSYPELFLLPDALDPSEEAGAMSAFVHNRIPILQWTNATTGAAIlmgAACAQASCSsVQAFyRALLD
... |..| .          ||    |  ... ..||.|. .|  .  .|   ..|   ..|||.| | .  ... |   . ..|     ..   |.  |
eEykRlgikses.......eWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknsti...tRssqplvG.ltks.rseed

-LRVKPVRGQNAQGSqrlmdlklqklpvskgS----DAQPQIvvlgdNASTQDPQIPGVTFIDVTMASRPLITSVATIHEMARELSVLA---AGLDTG--
 . .. .|  ..|..                .    ||.|..     ||...  .. |.  |.    .     ... |||.   |  |        .   
Eklinsirkaktqle................tlyildarpka.....navansakgagyedisryenceieflnienihelreslkklkkavnsiiekek

SFWRDLDKIGWLTQVADLLHWSNVIADLCTETHAVVVIAMEHGCDAAMQLTSLAMLQLDTHYRQLDAFMAhIINRVWIQHGHPFAARAGLvaakpsprsa
 .. .|.. .|| ..  ||. |. |..|  . .  |.. .  | |.  ||.||..| ||..|| . .|.  .|.. |.. || || | |           
nwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFiv.liekewlsfGhkfaqRigq..........

ELSGVAGLPAPTFGLFLDCVYQMLSQFPAQFEFNAELLEAIFHHSYSARFGNFLCNDQAYRD--RLGIDMDDLFAfVMDAHAktPQYANLMYSACNAHVL
. .      .| |  |.|||||.. ||| .||||...|  | ...||.|||.||.. .  |   .|  ..  |.| ...|.    .| | .| . . .  
ttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydsekeRqqnnlaketvslWa.lleank..seylnplyilekkeqk

--------RTNAALPMMQLWRQVYM
        ...| . ...||.. |.
enitssessssadikliklWseyyl
subfamily_MTMR1_pd Subfamily MTMR1 1821-2205 1e-49 161.9 In-house 26-384 (389) alignment 
Range on Protein: 1821-2205
Range on HMM: 26-384/389.0
GWRAVP-NHGFRKVHSYPELFLLPDALDPSEEAGAMSAFVHNRIPILQWTNATTGAAILMGAACAQascsSVQAFYRALLDLRVKPVRGQNAQGsQRLMD
 ||..  |. .    .||... .| . . ..  .. .   ..|.|.|.| | ...|.||  ..  .     ...  ..  .  .. ..  |||  ..|. 
lWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplv....Glsgkrskedekylqaileanaqs.eklli

LKLQklPVSKGsdAQPQIVvLGDNASTQDPQIPGVTFIDVTMasrplITSVATIHEMARElsVLAAGLDTGSFWRDLDKIGWLTQVADLLHWSNVIADLC
|  .  . ...   . ..   .. .|..  .   ..|.|..      | .|   ..  .|  .. . .|  ..  .|..  || .. ..|. .  |..  
ldar..ssvna..vankak.gkgyeseeaYknaelifldihn.....ihvvReslkklke..lvlpnvddkkwlsalestkWlehiklilagavkivekv

TETHAVVVIAMEHGCDAAMQLTSLAMLQLDTHYRQLDAFMAhIINRVWIQHGHPFAARAGLvaakpsprsAELSGVAGLPAPTFGLFLDCVYQMLSQFPA
..... |.. .. | |   ||||||||.||..|| .. |   .|.. |.. ||.|. | |          .. .      .| |  |.|||.|.  ||| 
etektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfev.liekeWlsfGHkfkeRlgh.........gdknssdaersPvFlqfiDcvwqltrqfpt

QFEFNAELLEAIFHHSYSARFGNFLCNDQAYRDRLGIDMDDlFAFVMDAHAKTPQYANLMYSAC-NAHVLRTNAALPMMQLWRQVYM
 ||||.|.|  .  |.||..||.||.| .. | .  ..     ..    .... .. | .|.   . .||  .|.| ...||.. |.
AFefneefLitlldhlysclfGtflfnsekervkekvkekt.vslwsyvnsskeeftnplyaeelekkvlypkaslrrlelWkeyyl
0040695 (Phosphotyrosine protein) phosphatases II 1825-2206 1.8e-51 169.0 In-house 31-384 (388) alignment 
Range on Protein: 1825-2206
Range on HMM: 31-384/388.0
VPNHGFRKVHSYPELFLLPDALDPSEEAGAMSAFVHNRIPILQWTNATTGAAILMGAACAQASCSSVQAFYRALLDLRVKPVRgqnaqgsqrlmdlklqk
  | ..   .||| |...|  .. .. . ... . ..|||.| . ....||..|  .   .  . | .  .. ||.  .|  .                 
ivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrsledeklleailkllp.................

lpvskgsdaqpqivvlgdnastqdpQI---------------------PGVTFIDVTMASRPLITSVATIHEMA----RELSVLAAGLDTGSFWRDLDKI
                         .                       || ..| .   . .  ..  || .     . |...    |. ...  |...
.........................nlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldaclnvpdslnllsllees

GWLTQVADLLHWSNVIADLCTETHAVVVIAMEHGCDAAMQLTSLAMLQLDTHYRQLDAFMAHiINRVWIQHGHPFAARAGLVAAKPsprsaelsgVAGLP
||| ..  .| .. .|..| .  . .|..  . | |   ||.|||.| || .|| |. |.   | . |.. ||.|| | |..                  
gwldliklilelavlivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvL.iekeWlsfghkfadRlghlesei.........dskef

APTFGLFLDCVYQMLSQFPAQFEFNAELLEAIFHHSYSARFGNFLCNDQAYRDRLGIdMDDLFAFVMDAHAKTPQYANLMYSACNAHVLRTNAALPMMQL
.|.| ||||||.|.| ||| .||||  ||  ...|.|| |||.||.|..  | .|.. .. .. ..      . .. |..|.    .||. .  .. ..|
sPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlyscrfgtFlfnsekerlelsv.sertlslwsyllsrkseflnplYdpsslevllpslsvldlll

WRQVYMP
| ..|..
Wleyylr
subfamily_MTMR3_pd Subfamily MTMR3 1967-2206 2.8e-37 121.5 In-house 215-441 (442) alignment 
Range on Protein: 1967-2206
Range on HMM: 215-441/442.0
ITSVATIHEMARELsvLAAGLDTGSFWRDLDKIGWLTQVADLLHWSNVIADLCTETHAVVVIAMEHGCDAAMQLTSLAMLQLDTHYRQLDAFMAhIINRV
| .| .  .  |.|  |. . |.  ..  |.|  || ... ||. .  ...   .    |..    | | . |...|| | || .|| |. | . ...| 
ihavrksfnslral..lsqspdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalakllldpyyrtleGfkv.lvere

WIQHGHPFAARAGLvaaKPS-PRSAElsgvaglPAPTFGLFLDCVYQMLSQFPAQFEFNAELLEAIFHHSYSARFGNFLCNDQAYRDRLGIDMDDLfAFV
|.. || || |.|    ..    . |        .| |  .||.|.|.  |||. ||||   |  . .|.||. || ||.| .  | .  .    |    
WldfGhkfadrcgh...genvddane.......rcPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekereeekvkertl.svW

MDAHAKTPQYANLMYSACNAHVLRTNAALPMMQLWRQVYMP
   .||  .| ||.|.  . .|| ..  .  ..||..||..
sllrakekeyrnllykekteavllpavsvrelklwsevyle
subfamily_MTMR6_pd Subfamily MTMR6 1987-2205 1.9e-36 118.2 In-house 187-393 (397) alignment 
Range on Protein: 1987-2205
Range on HMM: 187-393/397.0
LDTGSFWRDLDKIGWLTQVADLLHWSNVIADLCTETHAVVVIAMEHGCDAAMQLTSLAMLQLDTHYRQLDAFMAhIINRVWIQHGHPFAARAGLVaakpS
 .. .|.. |.. |||  .  .|. | .||   .| .| |..    | | . | .||| | ||..|| .. |.  .|.. |.  || |  |.||.    .
ksvseflsglessgwlkhikavldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrtikGflv.liekewlsfGhkfsercGll....d

PRSAELSgvaglpaPTFGLFLDCVYQMLSQFPAQFEFNAELLEAIFHHSYSARFGNFLCNDQAYRDRLGIDM--DDLFAFVMDahaKTPQYANLMYSACN
  | |.|       | |  ||.||.|.|.|||  |||| . | .. .| ||..||.||.| .  |  | .      |.|....   .. .|.| .|.| .
edskevs.......PiftqflecvwqlleqfpkafefnerfllelhdhvyscqfGtflgncekdrrdlklkertkslwaylle...rkddylnplykaet

A-HVLRTNAALPMMQLWRQVYM
  .||... |  ...||| .|.
ekevlkpdtapaalklwralyn
subfamily_MTMR5_pd Subfamily MTMR5 1988-2201 1.1e-39 128.6 In-house 262-476 (483) alignment 
Range on Protein: 1988-2201
Range on HMM: 262-476/483.0
DTGSFWRDLDKIGWLTQVADLLHWSNVIADLCTETHAVVVIAMEHGCDAAMQLTSLAMLQLDTHYRQLDAFMAhIINRVWIQHGHPFAARAGLVAAKPSP
.. || . ...  ||.|.  ||. |....||     . |....| | |.  |..||| | || .|| |. | . .... |.  || |. |. .. .. | 
esqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqllldpyYRtleGFkv.LveKEWLafGHrFtkrsnqtlsaqss

rsaelsGVaglpAPTFGLFLDCVYQMLSQFPAQFEFNAELLEAIFHHSYSARFGNFLCNDQAYRDRLGI--------DMD----DLFAFVMDAHAKTPQY
      |.    ||.|  |||||.|. .||| .||||   |. . .|| | ||  || . .  |   |.         ..     .. ..   | ..| .
......gf....aPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesgllyeekaekrakkagksvwdyidrqhkrspif

ANLMYSACNAHVLRTNAALPMMQLWR
 | .||  ...||| .. .. ...| 
ynflyspdesevlrPssnvsslkvWd
subfamily_pats1_pd Subfamily pats1 1990-2077 5.4e-11 33.6 In-house 367-456 (691) alignment 
Range on Protein: 1990-2077
Range on HMM: 367-456/691.0
GSFWRDLDKIGWLTQVADLLHWSNVIADLCTETHAVVVIAMEHGCDAAMQL---TSLAMLQLDTHYRQLDAFMAhIINRVWIQHGHPFAAR
 . |... .  |.  |  ||. .  .. |  | ..|..     . .  ..|   .|||.. .| .|| || |.  .|.. |...|.||. .
ddewkeieeskwvdsvkllleaavkvsnlldeGssvllknsidsPlieldlasisslaqvlsdPfyrtldGfkv.liekewlsyGfPfski
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 1991-2205 3.3e-23 74.1 In-house 202-402 (405) alignment 
Range on Protein: 1991-2205
Range on HMM: 202-402/405.0
SFWRDLDKIGWLTQVADLLHWSNVIADLCTETHAVVViAMEHGCDAAMQLTSLAMLQLDTHYRQLDAFMAhIINRVWIQHGHPFAARAGLVAAKPSPRSa
 ||  ... ||....  .|  . . |.|     ...|     | | . |.|||. . || .|| .  |   .|.. |.  || |. | | .  .   || 
rfwgyieetgwishiksileaatfsaelilkgnsilv.hcsdgwdrtpqitsltqilldpyyrtivgfqv.liekewlsfghkfslrlghlpgneeers.

elsgvaglpaPTFGLFLDCVYQMLSQFPAQFEFNAELLEAIFHHSYSARFGNFLCNDQAYRDRLGIDMDDlFAFVMDAHAKTPQYANLMYSACNAHVLRT
          | |  ||||..|.|||||  |||   ||  |    .|...| || | .  | .  . .    .   . . .  .. |  |   . . .. 
..........pifqqfldccfqllsqfpllfeftpslllfisdnihsckygtflnncekdrvqdqvktkt.isiwsevnlnvnkflnpyynpqdiqsikp

NAALPMMQLWRQVYM
.     ..||. .||
klysrclelwkacym
subfamily_MTMR10_pd Subfamily MTMR10 1992-2194 4.6e-31 99.9 In-house 155-346 (380) alignment 
Range on Protein: 1992-2194
Range on HMM: 155-346/380.0
FWRDLDKIGWLTQVADLLHWSNVIADLCTETHAVVVIAMEHGCDAAMQLTSLAMLQLDTHYRQLDAFMaHIINRVWIQHGHPFAARAGLVAAKPSPRSae
.   |.| .||  |  .|. .  .... .|..  |..  . | | .. . ||| |.|| ||| .. |    |.. |.  ||||  |.| .. ... .|  
wlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisGfq.sliqkewvaaghpfldrlghikpsekses..

lsgvaglpaPTFGLFLDCVYQMLSQFPAQFEFNAELLEAIFHHSYSARFGNFLCNDQAYRDRLGIDMDDLFAFVMDAHAKTPQYANLMYSA-CNAHVLRT
         |.| ||||||.| | |||..|||.  .| |.. .|.|  |..||.| .. | .   .   |   ... . .  .  .| |.. ..|.  . 
.........pvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltflfnseeqrlkavvsssplliakselkendllkdeldyrqglyaeiiks

NAAL
. .|
irrl
subfamily_pats1_pd Subfamily pats1 2100-2151 7.9e-13 39.6 In-house 553-604 (691) alignment 
Range on Protein: 2100-2151
Range on HMM: 553-604/691.0
APTFGLFLDCVYQMLSQFPAQFEFNAELLEAIFHHSYSARFGNFLCNDQAYR
.| |  ||| |.|.  .||  ||||  ||  . ..|.|.||||||...   .
sPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrd