Gene OCA-2 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family OCA
Subfamily OCA
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP027_AA protein Get Run
MbreP027_AA_62-399 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_OCA_pd Subfamily OCA 61-118 6.2e-06 15.8 In-house 138-195 (282) alignment
Range on Protein: 61-118
Range on HMM: 138-195/282.0
TAHLETVANFRDICRVAT---LIKPYCIFRSSTPSQATQKdaaLLMEQVGIKTIIDFREQS
...|... ..|... |..    .......|...|.... .   .|....|.||..  . ..
fprlyslvpprnfslveeykdkpvisgllrlllpeeenlp...fLidrlglktaliLdaee

0051429 (Phosphotyrosine protein) phosphatases II 63-126 6.1e-10 34.7 In-house 2-64 (272) alignment
Range on Protein: 63-126
Range on HMM: 2-64/272.0
HLETVANFRDICRVATLIKPYCIFRSSTPSQATQKDAALLmEQVGIKTIIDFREQSESLRDCGA
.|... |.||.      .||  ..||. |...|..| . | .. |||||.|.|. .|  |.   
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcd

0051082 (Phosphotyrosine protein) phosphatases II 64-399 5.6e-19 63.7 In-house 2-133 (151) alignment
Range on Protein: 64-399
Range on HMM: 2-133/151.0
LETVANFRDICRVatlikpycIFRSSTPsqaTQKDAALLmEQVGIKTIIDFREQSESLrdcgacLLRE-----Qypefdlesqpgdkckeimrrmekipi
|... ||...           ..||. |   .. . .|| .. |||||...|.  |         . |     .                          
lsdyinfsyvtgg........lyrsggp...ladflell.kelgiktivnlrseeerg......ycpeylpelg..........................

ttfaaqdirqatspsiprrpsaierdrerraraqqstssdsstepsrptfrldasvmvdevfdshdaastphatqtdkatptasqkepatgagdnntlda
                                                                                                    
....................................................................................................

edievvtlpgqrrlvrvpycprkvM-------------KkvvfgmlnnkdlgkvacwmflgglffrkkwrergksvakrrfnkvgllgfykvlMTRSYAA
                        .             .                                                      .  |..|
........................ievlhipildwpdpg......................................................lplsfda

ICSVLQICADARNHPIMLHCSHGKDRTGVTTAVLLAALGVSDEAIAADYALSDD
. ..|....| .|.|.  |||.||.|||.  |..| .|||| |.. ..| |.  
vleflellldkkngpvlvHCsaGkgRTGtlvalylmllgvsleealeeyrlkrp

Y_phosphatase3 Tyrosine phosphatase family 69-153 2.2e-09 32.5 Pfam-A 1-88 (164) alignment
Range on Protein: 69-153
Range on HMM: 1-88/164.0
NFRDICRVAT----LIKPYCIFRSSTPSQATQKDAALLMeQVGIKTIIDFREQSESLRDCGACLLREQYPEFDLESQPGDKCKEIMRRM
||||.  ..|     ..|  ..||.. |..|..|.| |  ..||||..|.|...|  ..        .| .......  .. .|. .|.
NfRDlGgyptadgrtvrpgvlyRSaalsklteadlaaLa.elgiktvvDLRseeEvekepdklpegvkyvnlpvlkeeaespeelaerl

0044763 (Phosphotyrosine protein) phosphatases II 76-386 2.7e-08 29.2 In-house 22-139 (178) alignment
Range on Protein: 76-386
Range on HMM: 22-139/178.0
VATLIKPYcIFRSSTPSqatqKDAALLMEQVGIKTIIDFREQSESLRdcgacllreQ----------Ypefdlesqpgdkckeimrrmekipittfaaqd
 |. | |. ....| |.     |   |. . ||..|....|  |  .         .                                           
naseilpg.lylgslpp....addlellkelgithivnlteelelgf.........lkcdpywpeeag................................

irqatspsiprrpsaierdrerraraqqstssdsstepsrptfrldasvmvdevfdshdaastphatqtdkatptasqkepatgagdnntldaedievvt
                                                                                                    
....................................................................................................

lpgqrrlvrvpycprkvmkkvvfgmlnnkdlgkvacwmflgglffrkkwrergksvakRRFNKVGLLGFYKVLMTRSYAAICSVLQICADARNHPIMLHC
                                                           .. .... ..    ...   ...  .. . | ...|.  ||
..........................................................iqylhipipDhgvpdllehflefvefieealdekggpvlVHC

SHGKDRTGVTTAV-LLAALGVS
|.|..|.|.  |  |.  ||.|
saGvgRsgtlvaaylmkklgls

Y_phosphatase3 Tyrosine phosphatase family 324-397 1.2e-19 65.9 Pfam-A 91-163 (164) alignment
Range on Protein: 324-397
Range on HMM: 91-163/164.0
RRFNKVGLLGFYKVLMTRSYAAICSVLQICADARnHPIMLHCSHGKDRTGVTTAVLLAALGVSDEAIAADYALS
.. ..  .  .|. ..... .|. .||...|... .|...||..|||||||..|.||..|||..|.|||||.|.
aeeaeeamaeayreiledekkayrkvlealaeee.gpvlfHCtaGKDRTGvvaalllsllgvdeetiaaDYllt

0036282 (Phosphotyrosine protein) phosphatases II 324-385 3.5e-08 28.8 In-house 70-131 (174) alignment
Range on Protein: 324-385
Range on HMM: 70-131/174.0
RRFNKVGLLGFYKVLMTRSYAAICSVLQICADARNHPIMLHCSHGKDRTGVTTAVLLAALGV
 .. ...  ..    ..  . ... | ..... ...|.  |||.|..|||.  | .|   | 
iqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgl

subfamily_OCA_pd Subfamily OCA 325-467 3e-21 66.0 In-house 146-278 (282) alignment
Range on Protein: 325-467
Range on HMM: 146-278/282.0
RFNKVGLLGFYKVlmtrsYAAICSVLQ-ICADARNHPIMLhcshgkDRTGVTTAVLLAALGVSDEAIAaDYalsddYGNSPEGRQRFDTECPELDPDEWA
......|.  ||.     ...|...|. .... .|.|...      ||.|..||..|.| .|..|.|| |.     . .| .. .....|. .   |.. 
pprnfslveeykd.....kpvisgllrlllpeeenlpfLi......drlglktaliLdaeeveretia.df.....lasseiklvslrnevlkdlldndn

-------RARPETMLQLMQWvREEFGGIDGYLDLIGFDGHWRHKLRQNLLV
       .|. .|.|.....  ...| .. ||. |||.......|...||.
yavelscqaktdtvlkvLrk.dkkygstsiyleyigFtledqeslksilli

0051429 (Phosphotyrosine protein) phosphatases II 334-466 7.8e-29 96.6 In-house 126-272 (272) alignment
Range on Protein: 334-466
Range on HMM: 126-272/272.0
FYKVLMTRSY--AAICSVLQICADarNHPIMLHCSHGKDRTGVTTAVLLAALGVSDEAIAADYALSDDY--------------GNSPEGRQRFDTECPEL
.|    ....   |....|....|  ..|.. |||.||||||.  |.|| .||||.|.|..||.|.. |               .  |.  .|  |.   
hytdwpdhgvpqeallellellld..ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyealle

DPDEWARARPETMLQLMQWVREEFGGIDGYLDLIGFDGHWRHKLRQNLL
  .... .|.|..|. .....||.|...|||  .|.. .....||..||
llrsllsvraeyllaaldaideeyGsvegYLrdlglseeelerLrellL

Y_phosphatase2 Tyrosine phosphatase family 339-379 1.4e-07 23.4 Pfam-A 72-112 (165) alignment
Range on Protein: 339-379
Range on HMM: 72-112/165.0
MTRSYAAICSVLQICADARNHPIMLHCSHGKDRTGVTTAVL
.   .  .  .|..  . .|.|..|||..|| |||.  ..|
veiksdllkkalklllnkenypvllhckrGkhrtglvigcl

0049772 (Phosphotyrosine protein) phosphatases II 343-396 6.8e-11 37.9 In-house 196-252 (314) alignment
Range on Protein: 343-396
Range on HMM: 196-252/314.0
YAAICSVLQICAD-ARNHPIMLHCSHGKDRTG--VTTAVLLAALGVSDEAIAADYAL
 . . ..|... .  ...|.  ||..||.|||  |..| |. .|||| | . .|. |
ledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrl

0042113 (Phosphotyrosine protein) phosphatases II 345-394 2.2e-09 32.6 In-house 163-218 (245) alignment
Range on Protein: 345-394
Range on HMM: 163-218/245.0
AICSVLQICADARNHPIMLHCSHGKDRTGVTTAVLL------AALGVSDEAIAADY
..  |....|. .|.|.. |||.|..|||.  |..|      . |||| | . ...
flefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkel

0049260 (Phosphotyrosine protein) phosphatases II 345-388 5e-07 25.0 In-house 76-119 (152) alignment
Range on Protein: 345-388
Range on HMM: 76-119/152.0
AICSVLQICADARNHPIMLHCSHGKDRTGVTTAVLLAALGVSDE
 .. .....|  ...|.  |||.|..|||.  | .|  |||| |
flllfieklaldkggpvlVHCsaGvgRtgtlvaaylmllgvsle

0045450 (Phosphotyrosine protein) phosphatases II 345-388 8.3e-07 24.5 In-house 220-264 (307) alignment
Range on Protein: 345-388
Range on HMM: 220-264/307.0
AICSVLQICADA-RNHPIMLHCSHGKDRTGVTTAVLLAALGVSDE
 |  |......  ...|.. |||.|..|||.  | .|.  .. .|
fieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqleke

PTPc_DSPc_SM00012 345-388 1.3e-06 23.9 In-house 21-69 (105) alignment
Range on Protein: 345-388
Range on HMM: 21-69/105.0
AICSVLQICADARN-----HPIMLHCSHGKDRTGVTTAVLLAALGVSDE
.|...|. . . .|     .|...|||.| .|||. .|. ..   ...|
silellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleke

0041856 (Phosphotyrosine protein) phosphatases II 345-386 2.8e-06 22.6 In-house 97-138 (182) alignment
Range on Protein: 345-386
Range on HMM: 97-138/182.0
AICSVLQICADaRNHPIMLHCSHGKDRTGVTTAV-LLAALGVS
 ... .... . ...|.  |||.|..|||.  |  |.  ||||
elldfieevle.eggpvlVHCsaGvgRtgtlvaaylmkklgvs

0043147 (Phosphotyrosine protein) phosphatases II 345-386 3.8e-06 22.2 In-house 87-128 (172) alignment
Range on Protein: 345-386
Range on HMM: 87-128/172.0
AICSVLQICADARNHPIMLHCSHGKDRTGVTTAVLLAALGVS
..  . ...|  ...|.  |||.|..|||.  | .|  ||.|
flefidellalspggpvlVHCsaGvgRtgtlvaaylmllgls

0043336 (Phosphotyrosine protein) phosphatases II 346-394 6.3e-08 27.9 In-house 199-252 (278) alignment
Range on Protein: 346-394
Range on HMM: 199-252/278.0
ICSVLQICAdARNHPIMLHCSHGKDRTGVTTAVLLA------ALGVSDEAIAADY
.  |.....  .|.|.. |||.|..|||.  |..|.       .||. | . ...
lkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkel

0040439 (Phosphotyrosine protein) phosphatases II 346-394 6.4e-08 28.0 In-house 166-221 (249) alignment
Range on Protein: 346-394
Range on HMM: 166-221/249.0
ICSVLQICADA-RNHPIMLHCSHGKDRTGVTTAVLLA------ALGVSDEAIAADY
|  |....... ...|.. |||.|..|||.  | .|.       |||. | . ...
ieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkll

0048179 (Phosphotyrosine protein) phosphatases II 346-388 1.3e-06 23.7 In-house 69-114 (144) alignment
Range on Protein: 346-388
Range on HMM: 69-114/144.0
ICSVLQICADA--RNHPIMLHCSHGKDRTGVTTAV-LLAALGVSDE
....|... .|  ...|.  |||.|..|||.  |  |.  ||.| |
lleflefieealeeggpvlVHCsaGvgRtgtlvaaylmkklglsle

0039614 (Phosphotyrosine protein) phosphatases II 346-386 1.5e-06 23.4 In-house 209-256 (297) alignment
Range on Protein: 346-386
Range on HMM: 209-256/297.0
ICSVLQICADA-RNHPIMLHCSHGKDRTGVTTAVLLA------ALGVS
.  | ...| . ...|.  |||.|..|||.  | .|.        ||.
lelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd

0048076 (Phosphotyrosine protein) phosphatases II 347-390 9.1e-07 24.2 In-house 68-114 (145) alignment
Range on Protein: 347-390
Range on HMM: 68-114/145.0
CSVLQIC--ADARNHPIMLHCSHGKDRTGVTTAV-LLAALGVSDEAI
...|...  | ....|.  |||.|..|||.  |  |.  |||| | .
leflefieealkeggpvlVHCsaGvgRtgtlvaaylmlllgvsleea

0040438 (Phosphotyrosine protein) phosphatases II 348-381 1.9e-06 22.8 In-house 199-232 (317) alignment
Range on Protein: 348-381
Range on HMM: 199-232/317.0
SVLQICADARNHPIMLHCSHGKDRTGVTTAVLLA
. .. . . ...|.. |||.|..|||.  |..|.
eavrealedpggpvlVHCsaGvgRtGtfiaaylm

0045098 (Phosphotyrosine protein) phosphatases II 348-385 7.8e-06 21.0 In-house 187-233 (278) alignment
Range on Protein: 348-385
Range on HMM: 187-233/278.0
SVLQICA---------DARNHPIMLHCSHGKDRTGVTTAVLLAALGV
..|.  |         . ...|.  |||.|..|||.  |. |    .
ealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell

0037934 (Phosphotyrosine protein) phosphatases II 349-394 3.2e-07 25.6 In-house 169-216 (243) alignment
Range on Protein: 349-394
Range on HMM: 169-216/243.0
VLQICADARNHPIMLHCSHGKDRTGVTTAVLLAAL--GVSDEAIAADY
.|.. |. ...|. .|||.|..|||.  | .|  |  ||. | . ...
llsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkll

Y_phosphatase3C Tyrosine phosphatase family C-terminal region 424-466 1.8e-11 33.5 Pfam-A 25-68 (68) alignment
Range on Protein: 424-466
Range on HMM: 25-68/68.0
RARPETMLQLMQWVREEFGGIDGYL-DLIGFDGHWRHKLRQNLL
 .|.|.. . .....|..|...||| . .|.. . . .||..||
gvreeyleaaldtideryGsvegYLeeaLGlseedierLRerlL