Gene PTEN-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily PTEN
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP028_AA protein Get Run
MbreP028_AA_446-631 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
BNIP2 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 242-319 7.7e-08 19.0 Pfam-A 20-96 (127) alignment
Range on Protein: 242-319
Range on HMM: 20-96/127.0
SASAMDRSAVEEPDEDQDASLDEPDSEDDVDSSSDEEEIDRKPSLPDAASAASVVEHDnVIHQGWLFKEGGQIRSWRR
  | .. .  |....| | |||. | .|| ||   |.|.. .  .| |..|..  |.   ..|    .|  ..| || 
disslsddvsessvddldlslddldtpddedsldvegeleweddtpkagaasesaees.slpqysaeeeardsrnWrk

PH PH domain 301-410 1.1e-16 51.3 Pfam-A 1-102 (104) alignment
Range on Protein: 301-410
Range on HMM: 1-102/104.0
VIHQGWLFKEGGQIRSWRRRYFVLQSNGLLVYFPDAPqasGRNSTPINAIDVVGAEVTQSTSS------KRPHGFIVASDQSakrrssatnkrEKYVLAG
||..|.| | ... ..|..|||||.|| ||.. ..       ...|. .|.. ...|.  .|.      .... | .  ...           |.|.|  
vikeGyllkksellktwkkryfvLtsnyLlyfksskk...ksykapkgsiplndctvkkasstkfgaqkesnnyfeitfknv...........esyllsa

SSDADRDAWMARIRYC
.|. .| .|.. .. .
eseeerkrWvqalknl

PH_11 Pleckstrin homology domain 304-407 1.1e-07 21.9 Pfam-A 2-109 (112) alignment
Range on Protein: 304-407
Range on HMM: 2-109/112.0
QGWLFKEGGQ-IRSWRRRYFVLQSNGLLVYFPD-APQASGRNSTPINAIDVVGAEVTQSTSSKR---PHGFiVASDQSAKRRSSATNKREKYVLAGSSDA
.|.| | | . . .|.||.|.|. ...| |.     .  ..  |  . . .. ...  |  . .   ...   | ..| .. .|   . ....|.| .. 
kGylkkkgskllkgWkrrwfiLrkdnvleYyksprdksdvalitkesekvilkkdlsisnrlskianikdk.kalelshsnefsiaaeekslflkgdnne

DRDAWMARI
.. .|.  .
eteeWveal

subfamily_VSP_pd Subfamily VSP 445-634 7.2e-58 190.0 In-house 14-208 (212) alignment
Range on Protein: 445-634
Range on HMM: 14-208/212.0
NKVRQLVSKQKIRFQKDGFDLDLTYITPNIVAMGYPAEGTEAVYRNRYEDTLRFLEERHPGAYRVYNLCSERAYPPSRFHNRVGVYPFDDHNPAPLPLVL
. .|.|||..| |...|||||||||.|  |.|| .|. | ...|||  ..  |||...|. .|.|.|||||||| .. |.|||     ||||   |  .|
kaarrlvsenkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleell

ACCADIHAWLAANPErNVAAIHCKAGKGRTGLIISCYLMYAGICPDPDSAMTMFGAKRTHNG-----KGVTIPSQRRYIRYFHTMLQG-DRTVPPA
  . ... ||..... || ||||| |||||| |. ..|....|.   . ..  || .||...     .||  |||.||. |.. . .  .|..|||
vftkevkewlekdlk.nvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvktkynrklppa

subfamily_PTEN_pd Subfamily PTEN 447-628 3.2e-80 263.4 In-house 2-182 (184) alignment
Range on Protein: 447-628
Range on HMM: 2-182/184.0
VRQLVSKQKIRFQKDGFDLDLTYITPNIVAMGYPAEGTEAVYRNRYEDTLRFLEERHPGAYRVYNLCSERAYPPSRFHNRVGVYPFDDHNPAPLPLVLAC
.|..|||.|.||..||.||||.|||.||.|||||||..||.|||..||. .|||..| . |..|||.|||.|  ..|..|| |||||||||.|| |. ..
lrkivskkkkrfkedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleei

CADIHAWLAANPeRNVAAIHCKAGKGRTGLIISCYLMYAGICPDPDSAMTMFGAKRTHNGKGVTIPSQRRYIRYFHTMLQGD
. ||..||.... .||...||||||||||..|..||...........|...| ..||.|.|||||||||||..|....|. .
vediekwleedk.knvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyeklleee

0039614 (Phosphotyrosine protein) phosphatases II 447-624 4e-31 104.0 In-house 51-287 (297) alignment
Range on Protein: 447-624
Range on HMM: 51-287/297.0
VRQLVSKQKIRFQ--------------KDGFDLDLTYI-----------TPNIVAMGYPAEGT-----EAVYRNRYEDTL--------------------
 .  ..| | |..              .||.|||..||           |....|...| ..|     . |.... .  .                    
allpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeg

--------RFLEERHPGAYRVYNLCSERaYPPSRFHNRVGVYPFDDHNPAP-LPLVLACCADIHAWLAANPERNVAAIHCKAGKGRTGLIISCYLMY---
        ..|.. | . | |..|. .. . .||..... .... ||.. | | |.|  .  .. .||..|. .. ..||.||.|||| .| .|||.   
gtygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleql

-AGICPDPDSAMTMFGAKRthnGKGVTIPSQRRYIRYFHTM
  . ..|...|. ..  .|   ...|..||| |.....  .
ekeggvdvleavkelreqR...pgavqtpsqyrflydalle

0045450 (Phosphotyrosine protein) phosphatases II 448-623 6.7e-26 87.2 In-house 51-301 (307) alignment
Range on Protein: 448-623
Range on HMM: 51-301/307.0
RQLVSKQKIRFQK-------------------------------------DGFDLDLTYI----------------------------------TPNIVA
. ...| | |..                                      ||.||....|                                  . .. |
llpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekca

MGYPAEGTEAVYRNryeDTLRFLEERHPGAYRVYNLCSERaYPPSRFHNRVGVYPF---DDHNPAP-LPLVLACCADIHAWLAANPERNVAAIHCKAGKG
. .| ||.| .|.|   .| ..|.| | . | |..|. .. . .. .. .| ....    ||.  | .  .|. .  ....|...|. .. ..||.||.|
qywPdegeeltygn...ftvtllseehldgytvrtlevtd.ldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvg

RTGLIISCYLMYAGIC-------PDPDSAMTMFGAKRthnGKGVTIPSQRRYIRYFHT
||| .| .|||. ..        .|...|. .. ..|   ...|. |.| |.....  
RtGtfiaaylmlrqlekegtlldvdlleavkllreqR...pgavqnpeqyrflyeall

0037934 (Phosphotyrosine protein) phosphatases II 450-624 5.4e-29 96.9 In-house 8-240 (243) alignment
Range on Protein: 450-624
Range on HMM: 8-240/243.0
LVSKQKIRFQ--------------KDGFDLDLTYITPNIVAMGYPAEGTEAV---------YRNRYEDTL----------------------------RF
.... | |..               | ....|.|.||.. |...| ..| .          .... .  .                            ..
penlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtl

LEERHPGAYRVYNLCSER--AYPPSRFHNRVGVYPFDDHNPAP-LPLVLACCADIHAWLAA------NPERNVAAIHCKAGKGRTGLIISCYLMYAGICP
|.|.| . | |..|. |.  .....|.. ..  .|. ||.. .    .|. . ...... .      ... .. ..||.||.||||..| .|||.  .. 
lseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgv

DPDSAMTMFGAKRTHngKGVTIPSQRRYIRYFHTM
|...|. .. ..| .  |.|..|||.|...... .
dleeavkllreqRpg..kavqtpsqyrflyealle

0044763 (Phosphotyrosine protein) phosphatases II 450-631 5.9e-24 80.1 In-house 6-176 (178) alignment
Range on Protein: 450-631
Range on HMM: 6-176/178.0
LVSKQKIRFQKDGFDLDLTYITPNIVAMGYPAegteavyrnryEDTLRFLEERHPGayRVYNLCSE--------RAYPPSRFHNRVGVYPFDDHNPAP-L
.|. ....    .. .....|.|.. ....|.           .| |..| | . .   . ||..|         .| |.... ..  .|..||.. . |
rvllsnleglersdyinaseilpglylgslpp...........addlellkelgit..hivnlteelelgflkcdpywpeeagiqylhipipDhgvpdll

PLVLACCADIHAWLAANPerNVAAIHCKAGKGRTGLIISCYLMYAGICpDPDSAMTMFGAKRthnGkGVTIPSQRRYIRYFHTMLQGDRTV
  .|.... |...|. ..  .. ..||.||.||.|... .|||.   . ....|. .. ..|     .|. |.|.|....|. .|.. ...
ehflefvefieealdekg..gpvlVHCsaGvgRsgtlvaaylmkklgl.sleeaielvrerR...p.ivpnpgqlrqLyefelrllkesdl

0042113 (Phosphotyrosine protein) phosphatases II 452-623 4e-27 90.6 In-house 9-240 (245) alignment
Range on Protein: 452-623
Range on HMM: 9-240/245.0
SKQKIRF-------------QKDGFDLDLTYI----------TPNIVAMGYPAEGTEA-----VYRNRYED-----------------------------
.|.| |.             . ||.|||..||          ||.. |...|...| .     ..... .                              
nkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygd

-TLRFLEERHPGAYRVYNLCSER-AYPPSRFHNRVGVYPFDDHNPAP-LPLVLACCADIHAWLAAnPERNVAAIHCKAGKGRTGLIISCYLMY----AGI
 | ..|.| | . | |..|. ..  ...||.....  .|..||.... | |.| ..  .. .||. .. .. ..||.||.||||..| .|||.    .  
ftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmleqlekel

CPDPDSAMTMFGAKRthnGKGVTIPSQRRYIRYFHT
. ....|. ..  .|   .. |..||| |...... 
gvsleeavkelrsqR...pgavqtpsqyrflyeall

PTEN_1 455-627 9e-48 157.7 In-house 10-194 (196) alignment
Range on Protein: 455-627
Range on HMM: 10-194/196.0
KIRFQKDGFDLDLTYITPNIVAMG-YPAEG-----TEAVYRNRYEDTLRFLEERHP-GAYRVYNLCSERAY-----PPS-RFHNRVG--VYPFDDHNPAP
| .  .....|||||||. |.|||  |...      | .||....|  ..|..... |.. |.||..|...     ... .|...|    .|..||.. .
kknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgaps

LPLVLACCADIHAWLAANPERNVAAIHCKAGKGRTGLIISCYLMYAGIcPDPDSAMTMFGAKRTHNGKGvtIPSQRRYIRYFHTMLQG
|  ... |.... || ..|..||...|||||.||.|... .||||.|   ..| |. .. .||.....   .|||.|...||. .|..
lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn..spsqerlleyfaellae

0040438 (Phosphotyrosine protein) phosphatases II 455-624 3.8e-23 77.7 In-house 46-274 (317) alignment
Range on Protein: 455-624
Range on HMM: 46-274/317.0
K-------------IRFQKDGFDLDLTYI----------TPNIVAMGYPAEGTEAVYR-----NRYED------------------------------TL
|             .... .|.|||..||          .....|...| ..| . .      .. .                               | 
knrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftv

RFLEERHPGAYRVYNLCSERAYPPSRFHNRVGVYPF-DDHNPAP-LPLVLACCADIHAWLAanPERNVAAIHCKAGKGRTGLIISCYLM-----YAGiCP
..|.| . . . ...|. |  . .  .....  |.. .||.. | . |.|. .  ....|.  .. .. ..||.||.|||| .| .|||     . | ..
tllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gv

DPDSAMTMFGAKRthnGKGVTIPSQRRYIRYFHTM
|...|. .. ..|   ...|. |.| |.. ... .
dveeavkelreqR...pgavqtpeqyrflydalle

0043336 (Phosphotyrosine protein) phosphatases II 456-621 5.9e-27 90.2 In-house 62-272 (278) alignment
Range on Protein: 456-621
Range on HMM: 62-272/278.0
IRFQKDGFDLDLTYI----------TPNIVAMGYPAEGTEAVYRNRYED----------------------------------TLRFLEERHPGAYRVYN
.... .|.|||..||          .....|...| ..|.. ...   .                                  | ..|.| | . | |..
vklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrt

LCSER-AYPPSRFHNRVGVYPFDDHNPA-PLPLVLACCADIHAWLAanPERNVAAIHCKAGKGRTGLIISCYLMY----AGICPDPDSAMTMFGAKRthn
|. ..  ...||.....  ... ||.   .| |.|  . ... .|.  .. .. ..||.||.||||..| .||..     . ..|...|. ..  .|   
levtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR...

GKGVTIPSQRRYIRYF
.. |. ||| |.....
pgavqtpsqyrflyea

subfamily_Tensin_pd Subfamily Tensin 457-628 3.3e-42 137.1 In-house 3-174 (189) alignment
Range on Protein: 457-628
Range on HMM: 3-174/189.0
RFQKDGFDLDLTYITPNIVAMGYPAEGTEAVYRNRYEDTLRFLEERHPGAYRVYNLcSERAYPPSRFHNRVGVYPFDDHNPAPLPLVLACCADIHAWLAA
|. .. .||||||||  |.|. .||||.|. ||.  .|  ..|...|   |.|.|| ||. |  |.....|  . . |.   .|  . . | ....|| |
ryveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnl.sekrydisklnkkvldfGWPdllaPsleklcsicksldsWlka

NPErNVAAIHCKAGKGRTGLIISCYLMYAGICPDPDSAMTMFGAKRTHNGK--GVTIPSQRRYIRYFHTMLQGD
.|. ||...||| ||||.|...|.|. |. |.   |.|.  |  ||  . |  |.| ||||||..||  .|.| 
dpq.nvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgk

0046846 (Phosphotyrosine protein) phosphatases II 457-626 1.3e-34 114.8 In-house 2-173 (176) alignment
Range on Protein: 457-626
Range on HMM: 2-173/176.0
RFQKDGFDLDLTYITPNIVAMGYPAEGTEAVYRNRYEDTLRFLEErhpGAYRVYNLCSER--------AYPPS--RFHNRVGVYPFDDHNPAPLPLVLAC
|....|.||||.||..|......|. . . ..|. ...  ...|.   | . | ||..|.         |.|   ... .. ..|..||.. .| |.| .
rlrllgldldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllel

CADIHAWLAANperNVAAIHCKAGKGRTGLIISCYLMYAGICPDPDSAMTMFGAKRTHngKGVTIPSQRRYIRYFHTMLQ
.. |. .| ..   .. ..||.||.||||... .||.. . . ... |. .. ..| .  . |. |.|.|....|. .|.
lefirealkeg...gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl..gavqtpeQyrflyefellll

0040439 (Phosphotyrosine protein) phosphatases II 460-624 4.5e-23 77.6 In-house 34-244 (249) alignment
Range on Protein: 460-624
Range on HMM: 34-244/249.0
KDGFD--------LDLTYITPNIVAMGYPAEGTEAVYRNRYED-----------------------------------TLRFLEERHPGAYRVYNLCSER
...|.        .|..||.....|...| ..| . ...   .                                   | ..|.. . . | |..|. ..
pglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltn

-AYPPSRFHNRVGVYPFDDHNPA-PLPLVLACCADIHAWLAANPERNVAAIHCKAGKGRTGLIISCYLMY----AGICPDPDSAMTMFGAKRthnGKGVT
  ...||  . . .... ||.    .. .|. .  .. .|...|. .. ..||.||.||||..| .|||.       . |...|. ..  .|   ...|.
lydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqR...pgavq

IPSQRRYIRYFHTM
 |.| |.. ..  .
npeqyrflyealle

0043147 (Phosphotyrosine protein) phosphatases II 461-625 1.6e-30 101.5 In-house 9-160 (172) alignment
Range on Protein: 461-625
Range on HMM: 9-160/172.0
DGFDLDLTYITPNIVAMGYPaegteavYRNRYEDTLRFLEERHPGAyrVYNLCSE--RAYPPSRFHNRVGVYPFDDHNPAPLPLVLACCADIHAWLaANP
. ..|||.||.....|. .|       .|| ..| .|.| |.. ..  ..||...   ... .|.  ..  .|..||.. .| |.| ..  |. .| |. 
nasyldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidell.als

ERNVAAIHCKAGKGRTGLIISCYLMYagICPDPDSAMTMFGAKRthnGKGVTIPSQRRYIRYFHTML
. .. ..||.||.||||... .|||.   . ... |. .. .||   ...|..|||.|...||. .|
pggpvlVHCsaGvgRtgtlvaaylml..lglsleeavalvrekR...pgavqnpsqyrflyyfekll

0041856 (Phosphotyrosine protein) phosphatases II 461-625 3.6e-28 93.8 In-house 13-170 (182) alignment
Range on Protein: 461-625
Range on HMM: 13-170/182.0
DGFDLDLTYITPNIVAMGYPAEGTEAVYRNRYEDTLRFLEERHPGAY-RVYNLCsERAYPPSRFHN---RVGVYPFDDHNPAPlplVLACCADIHAWLAa
  ...||.||..|......||   .| ... .... .||.  .   .  . ||. |. |.|.....   ..  .|..||.. .   .  ... |...|. 
ydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpd...ldelldfieevle.

npERNVAAIHCKAGKGRTGLIISCYLMYAGiCPDPDSAMTMFGAKRTHngkGVTIPSQRRYIRYFHTML
  | .. ..||.||.|||| .. .|||.     ....|. ..  .| .   .|..|.| ......  .|
..eggpvlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrRpg...mvitpnqyfflqlallel

0045098 (Phosphotyrosine protein) phosphatases II 461-625 2e-23 78.6 In-house 3-271 (278) alignment
Range on Protein: 461-625
Range on HMM: 3-271/278.0
DGFDLDLTYITPNIVAMGYPAEGTEAVYRNRYE-------------------------------------------------------------------
....|||.... .....|.| | |.|.|.. ..                                                                   
alasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelg

------------------------DTLRFlEERHPGAYRVYNLCSERAYPPSRFHNRVGVYPFDDHNPAPLP---LVLACCADIHAWLA-----------
                        .. .. .. .   ..|.||..||.. .||. . .  .|..||.. .||    .| ..  |...|.           
rekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssll

ANPERNVAAIHCKAGKGRTGLIISCYLMYAGI--CPDPDSAMTMFGAKRthNGKGVTIPSQRRYIRYFHTML
.... .. ..||.||.|||| .. .|||.  .    |...| ...  .|  .|  |....| |.. .|. .|
lldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqR..pglavqnleqyrflyefllel

0046845 (Phosphotyrosine protein) phosphatases II 461-622 5.8e-22 73.8 In-house 66-270 (284) alignment
Range on Protein: 461-622
Range on HMM: 66-270/284.0
DGFDLDLTYITPNIVAMGYPAEGT-----------------------------EAVYRNRYEDTLRF-------LEERHPGAYRVYNLCSERA--YPPSR
||.|||||||.....|. .| ..|                              | |.. ....|..       |.| . . | |..|. ..     .||
dgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesr

FHNRVGVYPFDDHNPAP-LPLVLACCADIHAWLAANPERNVAAIHCKAGKGRTGLIISCYLMYAGI-------CPDPDSAMTMFGAKRTHngkGVTIPSQ
...   . .. ||.  | .  .|. . ... .| ..|  .. ..||.||.|||| .| ..|..  .       ..|. .|. ..  .| .    |. ..|
tvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpg...mvqtleq

RRYIRYFH
 |.. .. 
yrfvyeal

0036941 (Phosphotyrosine protein) phosphatases II 461-625 1.7e-15 52.6 In-house 72-276 (297) alignment
Range on Protein: 461-625
Range on HMM: 72-276/297.0
DGFDLDLTYI---------------------TPNIVAMG-------------YPAEGTEAVYRNRYedTLRFLEERH--PGAYRVYNLCSER-AYPPSRF
||.||. ..|                     .. || .              .| |  | .. ...  |...|.. .   . | ...|. .   ...||.
dgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdf..tvtllsvevvllddytlrtlevtdtgngesrt

HNRVGVYPFDDHNPAP-LPLVLACCADIHAWLAANPERNVAAIHCKAGKGRTGLIISCYLMY-------AGICPDPDSAMTMFGAKRTHngkGVTIPSQR
 .   .   .||.. .    .|. .  .. .|.. |. ..  .||.||.||.| .| ..||.          ..|. .|. ..  .| .    |. ..| 
vthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpg...avqtleqy

RYIRYFHTML
|.....  .|
rflyeallel

0036282 (Phosphotyrosine protein) phosphatases II 462-627 1e-40 134.6 In-house 7-171 (174) alignment
Range on Protein: 462-627
Range on HMM: 7-171/174.0
GFDLDLTYITPNIVAMGYPAEGTEAVYRNRYEDTLRFLEERHPGAYRVYNLCSERAYPPSRFHNRVGVYPFDDHNPAPLPLVLACCADIHAWLAAnPERN
 ..|||.||||...|...|..  | ..... .. ...|||...| |...|...|. . ..|.. ..  .|..||.. .|. .| ..  .. .|.  .. .
aspldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealse.dpgg

VAAIHCKAGKGRTGLIISCYLMYAGICPDPDSAMTMFGAKRTHNGKGVTIPSQRRYIRYFHTMLQG
. ..||.||.||||... .|||. |...... |. .. ..|......|..|||.|...||. .|.|
pvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekllsg

subfamily_Auxilin_pd Subfamily Auxilin 464-626 4.2e-42 136.7 In-house 8-165 (166) alignment
Range on Protein: 464-626
Range on HMM: 8-165/166.0
DLDLTYITPNIVAMGYPAEGTEAVYRNRYEDTLRFLEERHPGAYRVYNLcSERAYPPSRFHNRVGVYPFDDHNPAPLPLVLACCADIHAWLAANPeRNVA
|||..|||  |. | .||||.|  |.|  .|   ||| |||. | |||| |.| |.......||  . .  ..  .|  ... |.....|| ..| .|| 
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynl.sqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdp.knvv

AIHCKAGKGRTGLIISCYLMYAGICPDPDSAMTMFGAKRTHNGkgvTIPSQRRYIRYFHTMLQ
 .||| |.  .....| .|... . ..|.||...| .||.  |     ||..||. |.  .|.
vvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig...lspsekryleyladlla

0049772 (Phosphotyrosine protein) phosphatases II 464-626 2.1e-21 72.4 In-house 118-278 (314) alignment
Range on Protein: 464-626
Range on HMM: 118-278/314.0
DLDLTYITP---------------------NIVAMGYPaegteavyrnryedtlrfleeRHPGAYRVYNLCsERAYPPSRFHNRVGVY---PFDDHNPAP
||.. .| .                     .. ..|..                      .| | .. .|. |. |.|..| ...  |   |..|... .
dlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....................neptaadlellk.eelydpelferlgikylripvpDgsapl

LPLVLACCADIHAWlaanPERNVAAIHCKAGKGRTG-LIISCYLMYAGICpDPDSAMTMFGAKRTHNGKGVTIPSQRRYIRYFHTMLQ
|  ...... |...    .. .. ..|||||||||| ... .|||..  . ... |. .. .||. | . ..|.....|. ... .|.
ledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnpgfieqleqyefilealle

0051082 (Phosphotyrosine protein) phosphatases II 465-622 6.7e-26 86.1 In-house 6-148 (151) alignment
Range on Protein: 465-622
Range on HMM: 6-148/151.0
LDLTYITPNIVAMGYPAEgteavyrnryeDTLRFLeeRHPGAYRVYNLCS--ERAYPPSRFHN---RVGVYPFDDHNPAPLPLVLACCADIHAWLAAnPE
....|.|... ..|.| .           | |..|  .. | . ..||.|  ||.| |.....   .|  .|..|. . .||| .. ..... .|.. ..
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld.kk

RNVAAIHCKAGKGRTGLIISCYLMYAGicPDPDSAMTMFGAKRThngkGVTIPSQRRYIRYFH
 .. ..||.|||||||... .|||. |   ....|. .. .||.    ||..|.| ... .|.
ngpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp....gvvqpnqqflfqlfa

0038934 (Phosphotyrosine protein) phosphatases II 469-606 4.2e-30 100.2 In-house 15-160 (194) alignment
Range on Protein: 469-606
Range on HMM: 15-160/194.0
YITPNIVAMGYPAEG-----TEAVYRNRYEDTLRFLEERHPGAYRVYNLC-SERAYPPSRFHN---RVGVYPFDDH-NPAPLPLVLACCADIHAWLAANP
.||....|...|..|     .| .||. .|| .|.|.... . . |..|. .|| | |..|..   ..  .|| |. .. .| ..|  .  .. .|...|
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

ErNVAAIHCKAGKGRTGLIISCYLMYAGICpDPDSAMTMFGAKRTHNG
. .| |.|||||.||||... .||.|   . ... |. .|  || .  
g.gvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekRpgai

0049260 (Phosphotyrosine protein) phosphatases II 475-626 5.5e-29 96.2 In-house 5-150 (152) alignment
Range on Protein: 475-626
Range on HMM: 5-150/152.0
VAMGYPAEGTEAVYRNRYEDTLRFLEERHPGAYRVYNLCSERAYPPSRFHNRVGVYPFDDHNPAPLPLVLACCADIHAWLaANPERNVAAIHCKAGKGRT
.||.... .|.....| ..| .|.| | . ... ... ..|....   .. ..  .|..||.. .|. .|  . ... .| |  . .. ..||.||.|||
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRt

GLIISCYLMYagICPDPDSAMTMFGAKRthnGKGVTIPSQRRYIRYFHTMLQ
|... .|||.     ... |. .. .||    ..|. |.|.|.. .|...|.
gtlvaaylml..lgvsleeavalvrekR...pgavpnpgqlrflyefekllk

0048076 (Phosphotyrosine protein) phosphatases II 479-626 1.2e-23 78.8 In-house 3-143 (145) alignment
Range on Protein: 479-626
Range on HMM: 3-143/145.0
YPAEGTEAVYRNRYEDTLRFLEERHPGAYRVYNLCSERAYPPsRFHNRVGVYPFDDHNPAPL-PLVLACCADIHAWLAANperNVAAIHCKAGKGRTGLI
.|.| .. .|.. . ..|.. . .. | ..|.||.||. ..  |.. ..  .|..||.. .|  |.|.... |...|...   .. ..||.||.||||..
wpseilpglylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeg...gpvlVHCsaGvgRtgtl

ISCYLMYAgICPDPDSAMTMFGAKRTHngkGVTIPSQRRYIRYFHTMLQ
. .|||.     ....|. .. ..| .   .|. |.|.|....|...|.
vaaylmll.lgvsleealelvrsqrpg...avpnpgqlrflyefelell

0048179 (Phosphotyrosine protein) phosphatases II 479-624 1.5e-22 75.3 In-house 3-143 (144) alignment
Range on Protein: 479-624
Range on HMM: 3-143/144.0
YPAEGTEAVYRNRYEDTLRFLEERHPGAYRVYNLCSErAYPPSRFHN--RVGVYPFDDHNPAPL-PLVLACCADIHAWLAANperNVAAIHCKAGKGRTG
.|.| .. .|.. . ..|.. . .. | . |.||..|  .|..  ..  ..  .|..||.. .|  |.|.... |...|. .   .. ..||.||.||||
npseilpglylgslptaldlellkklgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieealeeg...gpvlVHCsaGvgRtg

LIISCYLMYAGIcPDPDSAMTMFGAKRThngKGVTIPSQRRYIRYFHTM
... .|||.     ....|. .. ..|     .|. |.|.|........
tlvaaylmkklg.lsleealalvrsrrp...gavpnpgqlrfLleyekl

0051429 (Phosphotyrosine protein) phosphatases II 480-605 5.7e-11 38.1 In-house 76-207 (272) alignment
Range on Protein: 480-605
Range on HMM: 76-207/272.0
PAEGTEAVYRNRYEDTLRFLEERHPGAYRVYNLCSERAYPPSRFhNRVGVYPFDDHNPAPLPLvlACCADIHAWLAAnpeRNVAAIHCKAGKGRTGLIIS
| ....|   . .  ....|.| .   | ...|. .. ....    .| .. . |    . |     . .. ..|..    .   .||.|||.|||... 
pilddsaptilygalrvtllseellldyilrellltlllsagea.revmhlhytdwpdhgvpq..eallellellld...ggpvlvHCsaGkdRTGtvva

CYLMYAGICPD------------PDSAMTMFGAKRTHN
..|...|.. .            .. |. .  |.| . 
llllllgvsletivddYlltnlyleeaveelraqrpga

0047943 (Phosphotyrosine protein) phosphatases II 495-621 1.6e-19 65.9 In-house 138-267 (273) alignment
Range on Protein: 495-621
Range on HMM: 138-267/273.0
TLRFLEERHPGAYRVYNLCSER-AYPPSRFHNRVGVYPFDDHNPA-PLPLVLACCADIHAWLAANPERNVAAIHCKAGKGRTGLIISCYLMY----AGIC
| ..|.| . . | |..|. ..  .. ||. . . .... ||.    |  .| .. ... .|.|.|. .. ..||.||.|||| .| ..|..    .. .
tvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekegg

PDPDSAMTMFGAKRTHngkGVTIPSQRRYIRYF
.|...|. ..  .| .   .|. |.|.|.. ..
vdvleavkllrsqRpg...mvqtpeqyrflyea

0051299 (Phosphotyrosine protein) phosphatases II 495-619 3.7e-15 51.6 In-house 150-279 (288) alignment
Range on Protein: 495-619
Range on HMM: 150-279/288.0
TLRFLEERHPGAYRVYNLCSERA--YPPSRFHNRVGVYPF----DDHNPAPLPLVLACCADIHAWLAanPERNVAAIHCKAGKGRTGLIISCYLMY----
| ..|.| . . | |..|. ..   . .. .. .| .. .    |.. |  . |.|. . ... .||  .  .. ..||.||.|||| .| ..|..    
tvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqle

AGICPDPDSAMTMFGAKRTHngkGVTIPSQRRYIR
.. ..|. .|. ..  .| .    |. |.| |.. 
keggvdvleavkrlreqRpg...mvqtpeqyrfvy

0050432 (Phosphotyrosine protein) phosphatases II 496-618 5.2e-11 37.9 In-house 170-291 (308) alignment
Range on Protein: 496-618
Range on HMM: 170-291/308.0
LRFLEERHPGAYRVYNLCSERAYPPSRFHNRVGVYPF--DDHNPAPLPLVLACCADIHAWLaanpERNVAAIHCKAGKGRTGLIISCYLM----YAGICP
...|.| . . | |..|. .    .  .. ..  |.   |.. |  .  .|. .  .. .|    . .. ..||.|| |||| .| ..|.     .. ..
vtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggv

DPDSAMTMFGAKRTHngkGVTIPSQRRYI
|. .|. ..  .| .    |. |.| ...
dvfeavkklReqRpg...mvqtpeqylfl

0048567 (Phosphotyrosine protein) phosphatases II 531-585 8.8e-07 23.4 In-house 44-102 (157) alignment
Range on Protein: 531-585
Range on HMM: 44-102/157.0
PFDDHNPAPLPLVLACCADIHAWLAANP-ERNVAAIHCKAGK---GRTGLIISCYLMYA
.| |. | .| ..   .  .. .|     .... |.|||||    |||...|.|||.. 
fffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilh

PTPc_DSPc_SM00012 535-590 1.2e-06 24.0 In-house 14-69 (105) alignment
Range on Protein: 535-590
Range on HMM: 14-69/105.0
HNPAPLPLVLACCADIHAWLAANPERNVAAIHCKAGKGRTGLIISCYLMYAGICPD
. | .   .|  ..... .  .. ...   .||.|| |||| ..  ....  ..  
gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleke

subfamily_PTPDC1_pd Subfamily PTPDC1 560-604 9e-11 36.5 In-house 114-157 (182) alignment
Range on Protein: 560-604
Range on HMM: 114-157/182.0
RNVAAIHCKAGKGRTGLIISCYLMYAGICpDPDSAMTMFGAKRTH
..  |.|| ||.||||..|.|||.||    ... |...  .||..
egkvavhChaGlGrtGvliacylvyakrl.taekaiklvrskrpk

subfamily_CDC14_pd Subfamily CDC14 562-584 2.1e-07 25.1 In-house 265-287 (328) alignment
Range on Protein: 562-584
Range on HMM: 265-287/328.0
VAAIHCKAGKGRTGLIISCYLMY
 .|.||||| |||| .|.||||.
aiavhCkaGLGrtGtLiacylmk

DSPc Dual specificity phosphatase, catalytic domain 562-605 2.4e-06 22.4 Pfam-A 75-117 (133) alignment
Range on Protein: 562-605
Range on HMM: 75-117/133.0
VAAIHCKAGKGRTGLIISCYLMYAGICpDPDSAMTMFGAKRTHN
  ..||.||  |.. .| .|||.   . . ..|. ..  .| . 
kvlVHCqaGisRSatliiaYlmktknl.slneAyefvkerrski

DSPc Dual specificity phosphatase, catalytic domain 562-605 2.4e-06 22.4 In-house 75-117 (133) alignment
Range on Protein: 562-605
Range on HMM: 75-117/133.0
VAAIHCKAGKGRTGLIISCYLMYAGICpDPDSAMTMFGAKRTHN
  ..||.||  |.. .| .|||.   . . ..|. ..  .| . 
kvlVHCqaGisRSatliiaYlmktknl.slneAyefvkerrski

subfamily_PTPMT1_pd Subfamily PTPMT1 563-605 2.8e-08 28.4 In-house 110-151 (171) alignment
Range on Protein: 563-605
Range on HMM: 110-151/171.0
AAIHCKAGKGRTGLIISCYLMYAGICpDPDSAMTMFGAKRTHN
  .|||||.||.. ...||||.   . .|..|...  .|| . 
vYvHCkaGrgRsatlvacylmkkekl.speeAlkalkkkRkii

PTEN_C2 C2 domain of PTEN tumour-suppressor protein 633-765 2.8e-24 76.8 Pfam-A 2-133 (134) alignment
Range on Protein: 633-765
Range on HMM: 2-133/134.0
PATPLTLTGIRLHGVPNYDFSGGCQPYYQVYQEGVLIFsSKPAELRQLQAYkRQTHRDIRFSCNMAIEGNIRIELWDCDRGFHSEEKMFAATFFTGMVE-
. ..|.|..|.|.|.||.. .|||.|. .||.. . .| ...|. .. . . |. .  . .. .. .|| ...|. . |    ..||.| . | | ..| 
npkrlelksiilegiPnfktrggckpkvkvyngkkkvf.kelasykdster.raktfivkepnrlpveGDvlveflhkdsklpkkekifrvwFNTsFiek

-GTSLRMVRQELDGAHKKKhLKMFEPQFAMELTFK
  . | . ..|||.|.|.|  | |...|..|| |.
nqnvltlpkneLDkalkdk.dkkfsknfkvelvfe