Gene PTEN-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily PTEN
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP028_AA protein Get Run
MbreP028_AA_446-631 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
BNIP2 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 242-319 7.7e-08 19.0 Pfam-A 20-96 (127) alignment 
Range on Protein: 242-319
Range on HMM: 20-96/127.0
SASAMDRSAVEEPDEDQDASLDEPDSEDDVDSSSDEEEIDRKPSLPDAASAASVVEHDnVIHQGWLFKEGGQIRSWRR
  | .. .  |....| | |||. | .|| ||   |.|.. .  .| |..|..  |.   ..|    .|  ..| || 
disslsddvsessvddldlslddldtpddedsldvegeleweddtpkagaasesaees.slpqysaeeeardsrnWrk
PH PH domain 301-410 1.1e-16 51.3 Pfam-A 1-102 (104) alignment 
Range on Protein: 301-410
Range on HMM: 1-102/104.0
VIHQGWLFKEGGQIRSWRRRYFVLQSNGLLVYFPDAPqasGRNSTPINAIDVVGAEVTQSTSS------KRPHGFIVASDQSakrrssatnkrEKYVLAG
||..|.| | ... ..|..|||||.|| ||.. ..       ...|. .|.. ...|.  .|.      .... | .  ...           |.|.|  
vikeGyllkksellktwkkryfvLtsnyLlyfksskk...ksykapkgsiplndctvkkasstkfgaqkesnnyfeitfknv...........esyllsa

SSDADRDAWMARIRYC
.|. .| .|.. .. .
eseeerkrWvqalknl
PH_11 Pleckstrin homology domain 304-407 1.1e-07 21.9 Pfam-A 2-109 (112) alignment 
Range on Protein: 304-407
Range on HMM: 2-109/112.0
QGWLFKEGGQ-IRSWRRRYFVLQSNGLLVYFPD-APQASGRNSTPINAIDVVGAEVTQSTSSKR---PHGFiVASDQSAKRRSSATNKREKYVLAGSSDA
.|.| | | . . .|.||.|.|. ...| |.     .  ..  |  . . .. ...  |  . .   ...   | ..| .. .|   . ....|.| .. 
kGylkkkgskllkgWkrrwfiLrkdnvleYyksprdksdvalitkesekvilkkdlsisnrlskianikdk.kalelshsnefsiaaeekslflkgdnne

DRDAWMARI
.. .|.  .
eteeWveal
subfamily_VSP_pd Subfamily VSP 445-634 7.2e-58 190.0 In-house 14-208 (212) alignment 
Range on Protein: 445-634
Range on HMM: 14-208/212.0
NKVRQLVSKQKIRFQKDGFDLDLTYITPNIVAMGYPAEGTEAVYRNRYEDTLRFLEERHPGAYRVYNLCSERAYPPSRFHNRVGVYPFDDHNPAPLPLVL
. .|.|||..| |...|||||||||.|  |.|| .|. | ...|||  ..  |||...|. .|.|.|||||||| .. |.|||     ||||   |  .|
kaarrlvsenkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleell

ACCADIHAWLAANPErNVAAIHCKAGKGRTGLIISCYLMYAGICPDPDSAMTMFGAKRTHNG-----KGVTIPSQRRYIRYFHTMLQG-DRTVPPA
  . ... ||..... || ||||| |||||| |. ..|....|.   . ..  || .||...     .||  |||.||. |.. . .  .|..|||
vftkevkewlekdlk.nvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvktkynrklppa
subfamily_PTEN_pd Subfamily PTEN 447-628 3.2e-80 263.4 In-house 2-182 (184) alignment 
Range on Protein: 447-628
Range on HMM: 2-182/184.0
VRQLVSKQKIRFQKDGFDLDLTYITPNIVAMGYPAEGTEAVYRNRYEDTLRFLEERHPGAYRVYNLCSERAYPPSRFHNRVGVYPFDDHNPAPLPLVLAC
.|..|||.|.||..||.||||.|||.||.|||||||..||.|||..||. .|||..| . |..|||.|||.|  ..|..|| |||||||||.|| |. ..
lrkivskkkkrfkedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleei

CADIHAWLAANPeRNVAAIHCKAGKGRTGLIISCYLMYAGICPDPDSAMTMFGAKRTHNGKGVTIPSQRRYIRYFHTMLQGD
. ||..||.... .||...||||||||||..|..||...........|...| ..||.|.|||||||||||..|....|. .
vediekwleedk.knvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyeklleee
0039614 (Phosphotyrosine protein) phosphatases II 447-624 4e-31 104.0 In-house 51-287 (297) alignment 
Range on Protein: 447-624
Range on HMM: 51-287/297.0
VRQLVSKQKIRFQ--------------KDGFDLDLTYI-----------TPNIVAMGYPAEGT-----EAVYRNRYEDTL--------------------
 .  ..| | |..              .||.|||..||           |....|...| ..|     . |.... .  .                    
allpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeg

--------RFLEERHPGAYRVYNLCSERaYPPSRFHNRVGVYPFDDHNPAP-LPLVLACCADIHAWLAANPERNVAAIHCKAGKGRTGLIISCYLMY---
        ..|.. | . | |..|. .. . .||..... .... ||.. | | |.|  .  .. .||..|. .. ..||.||.|||| .| .|||.   
gtygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleql

-AGICPDPDSAMTMFGAKRthnGKGVTIPSQRRYIRYFHTM
  . ..|...|. ..  .|   ...|..||| |.....  .
ekeggvdvleavkelreqR...pgavqtpsqyrflydalle
0045450 (Phosphotyrosine protein) phosphatases II 448-623 6.7e-26 87.2 In-house 51-301 (307) alignment 
Range on Protein: 448-623
Range on HMM: 51-301/307.0
RQLVSKQKIRFQK-------------------------------------DGFDLDLTYI----------------------------------TPNIVA
. ...| | |..                                      ||.||....|                                  . .. |
llpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekca

MGYPAEGTEAVYRNryeDTLRFLEERHPGAYRVYNLCSERaYPPSRFHNRVGVYPF---DDHNPAP-LPLVLACCADIHAWLAANPERNVAAIHCKAGKG
. .| ||.| .|.|   .| ..|.| | . | |..|. .. . .. .. .| ....    ||.  | .  .|. .  ....|...|. .. ..||.||.|
qywPdegeeltygn...ftvtllseehldgytvrtlevtd.ldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvg

RTGLIISCYLMYAGIC-------PDPDSAMTMFGAKRthnGKGVTIPSQRRYIRYFHT
||| .| .|||. ..        .|...|. .. ..|   ...|. |.| |.....  
RtGtfiaaylmlrqlekegtlldvdlleavkllreqR...pgavqnpeqyrflyeall
0037934 (Phosphotyrosine protein) phosphatases II 450-624 5.4e-29 96.9 In-house 8-240 (243) alignment 
Range on Protein: 450-624
Range on HMM: 8-240/243.0
LVSKQKIRFQ--------------KDGFDLDLTYITPNIVAMGYPAEGTEAV---------YRNRYEDTL----------------------------RF
.... | |..               | ....|.|.||.. |...| ..| .          .... .  .                            ..
penlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtl

LEERHPGAYRVYNLCSER--AYPPSRFHNRVGVYPFDDHNPAP-LPLVLACCADIHAWLAA------NPERNVAAIHCKAGKGRTGLIISCYLMYAGICP
|.|.| . | |..|. |.  .....|.. ..  .|. ||.. .    .|. . ...... .      ... .. ..||.||.||||..| .|||.  .. 
lseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgv

DPDSAMTMFGAKRTHngKGVTIPSQRRYIRYFHTM
|...|. .. ..| .  |.|..|||.|...... .
dleeavkllreqRpg..kavqtpsqyrflyealle
0044763 (Phosphotyrosine protein) phosphatases II 450-631 5.9e-24 80.1 In-house 6-176 (178) alignment 
Range on Protein: 450-631
Range on HMM: 6-176/178.0
LVSKQKIRFQKDGFDLDLTYITPNIVAMGYPAegteavyrnryEDTLRFLEERHPGayRVYNLCSE--------RAYPPSRFHNRVGVYPFDDHNPAP-L
.|. ....    .. .....|.|.. ....|.           .| |..| | . .   . ||..|         .| |.... ..  .|..||.. . |
rvllsnleglersdyinaseilpglylgslpp...........addlellkelgit..hivnlteelelgflkcdpywpeeagiqylhipipDhgvpdll

PLVLACCADIHAWLAANPerNVAAIHCKAGKGRTGLIISCYLMYAGICpDPDSAMTMFGAKRthnGkGVTIPSQRRYIRYFHTMLQGDRTV
  .|.... |...|. ..  .. ..||.||.||.|... .|||.   . ....|. .. ..|     .|. |.|.|....|. .|.. ...
ehflefvefieealdekg..gpvlVHCsaGvgRsgtlvaaylmkklgl.sleeaielvrerR...p.ivpnpgqlrqLyefelrllkesdl
0042113 (Phosphotyrosine protein) phosphatases II 452-623 4e-27 90.6 In-house 9-240 (245) alignment 
Range on Protein: 452-623
Range on HMM: 9-240/245.0
SKQKIRF-------------QKDGFDLDLTYI----------TPNIVAMGYPAEGTEA-----VYRNRYED-----------------------------
.|.| |.             . ||.|||..||          ||.. |...|...| .     ..... .                              
nkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygd

-TLRFLEERHPGAYRVYNLCSER-AYPPSRFHNRVGVYPFDDHNPAP-LPLVLACCADIHAWLAAnPERNVAAIHCKAGKGRTGLIISCYLMY----AGI
 | ..|.| | . | |..|. ..  ...||.....  .|..||.... | |.| ..  .. .||. .. .. ..||.||.||||..| .|||.    .  
ftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmleqlekel

CPDPDSAMTMFGAKRthnGKGVTIPSQRRYIRYFHT
. ....|. ..  .|   .. |..||| |...... 
gvsleeavkelrsqR...pgavqtpsqyrflyeall
PTEN_1 455-627 9e-48 157.7 In-house 10-194 (196) alignment 
Range on Protein: 455-627
Range on HMM: 10-194/196.0
KIRFQKDGFDLDLTYITPNIVAMG-YPAEG-----TEAVYRNRYEDTLRFLEERHP-GAYRVYNLCSERAY-----PPS-RFHNRVG--VYPFDDHNPAP
| .  .....|||||||. |.|||  |...      | .||....|  ..|..... |.. |.||..|...     ... .|...|    .|..||.. .
kknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgaps

LPLVLACCADIHAWLAANPERNVAAIHCKAGKGRTGLIISCYLMYAGIcPDPDSAMTMFGAKRTHNGKGvtIPSQRRYIRYFHTMLQG
|  ... |.... || ..|..||...|||||.||.|... .||||.|   ..| |. .. .||.....   .|||.|...||. .|..
lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn..spsqerlleyfaellae
0040438 (Phosphotyrosine protein) phosphatases II 455-624 3.8e-23 77.7 In-house 46-274 (317) alignment 
Range on Protein: 455-624
Range on HMM: 46-274/317.0
K-------------IRFQKDGFDLDLTYI----------TPNIVAMGYPAEGTEAVYR-----NRYED------------------------------TL
|             .... .|.|||..||          .....|...| ..| . .      .. .                               | 
knrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftv

RFLEERHPGAYRVYNLCSERAYPPSRFHNRVGVYPF-DDHNPAP-LPLVLACCADIHAWLAanPERNVAAIHCKAGKGRTGLIISCYLM-----YAGiCP
..|.| . . . ...|. |  . .  .....  |.. .||.. | . |.|. .  ....|.  .. .. ..||.||.|||| .| .|||     . | ..
tllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gv

DPDSAMTMFGAKRthnGKGVTIPSQRRYIRYFHTM
|...|. .. ..|   ...|. |.| |.. ... .
dveeavkelreqR...pgavqtpeqyrflydalle
0043336 (Phosphotyrosine protein) phosphatases II 456-621 5.9e-27 90.2 In-house 62-272 (278) alignment 
Range on Protein: 456-621
Range on HMM: 62-272/278.0
IRFQKDGFDLDLTYI----------TPNIVAMGYPAEGTEAVYRNRYED----------------------------------TLRFLEERHPGAYRVYN
.... .|.|||..||          .....|...| ..|.. ...   .                                  | ..|.| | . | |..
vklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrt

LCSER-AYPPSRFHNRVGVYPFDDHNPA-PLPLVLACCADIHAWLAanPERNVAAIHCKAGKGRTGLIISCYLMY----AGICPDPDSAMTMFGAKRthn
|. ..  ...||.....  ... ||.   .| |.|  . ... .|.  .. .. ..||.||.||||..| .||..     . ..|...|. ..  .|   
levtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR...

GKGVTIPSQRRYIRYF
.. |. ||| |.....
pgavqtpsqyrflyea
subfamily_Tensin_pd Subfamily Tensin 457-628 3.3e-42 137.1 In-house 3-174 (189) alignment 
Range on Protein: 457-628
Range on HMM: 3-174/189.0
RFQKDGFDLDLTYITPNIVAMGYPAEGTEAVYRNRYEDTLRFLEERHPGAYRVYNLcSERAYPPSRFHNRVGVYPFDDHNPAPLPLVLACCADIHAWLAA
|. .. .||||||||  |.|. .||||.|. ||.  .|  ..|...|   |.|.|| ||. |  |.....|  . . |.   .|  . . | ....|| |
ryveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnl.sekrydisklnkkvldfGWPdllaPsleklcsicksldsWlka

NPErNVAAIHCKAGKGRTGLIISCYLMYAGICPDPDSAMTMFGAKRTHNGK--GVTIPSQRRYIRYFHTMLQGD
.|. ||...||| ||||.|...|.|. |. |.   |.|.  |  ||  . |  |.| ||||||..||  .|.| 
dpq.nvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgk
0046846 (Phosphotyrosine protein) phosphatases II 457-626 1.3e-34 114.8 In-house 2-173 (176) alignment 
Range on Protein: 457-626
Range on HMM: 2-173/176.0
RFQKDGFDLDLTYITPNIVAMGYPAEGTEAVYRNRYEDTLRFLEErhpGAYRVYNLCSER--------AYPPS--RFHNRVGVYPFDDHNPAPLPLVLAC
|....|.||||.||..|......|. . . ..|. ...  ...|.   | . | ||..|.         |.|   ... .. ..|..||.. .| |.| .
rlrllgldldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllel

CADIHAWLAANperNVAAIHCKAGKGRTGLIISCYLMYAGICPDPDSAMTMFGAKRTHngKGVTIPSQRRYIRYFHTMLQ
.. |. .| ..   .. ..||.||.||||... .||.. . . ... |. .. ..| .  . |. |.|.|....|. .|.
lefirealkeg...gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl..gavqtpeQyrflyefellll
0040439 (Phosphotyrosine protein) phosphatases II 460-624 4.5e-23 77.6 In-house 34-244 (249) alignment 
Range on Protein: 460-624
Range on HMM: 34-244/249.0
KDGFD--------LDLTYITPNIVAMGYPAEGTEAVYRNRYED-----------------------------------TLRFLEERHPGAYRVYNLCSER
...|.        .|..||.....|...| ..| . ...   .                                   | ..|.. . . | |..|. ..
pglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltn

-AYPPSRFHNRVGVYPFDDHNPA-PLPLVLACCADIHAWLAANPERNVAAIHCKAGKGRTGLIISCYLMY----AGICPDPDSAMTMFGAKRthnGKGVT
  ...||  . . .... ||.    .. .|. .  .. .|...|. .. ..||.||.||||..| .|||.       . |...|. ..  .|   ...|.
lydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqR...pgavq

IPSQRRYIRYFHTM
 |.| |.. ..  .
npeqyrflyealle
0043147 (Phosphotyrosine protein) phosphatases II 461-625 1.6e-30 101.5 In-house 9-160 (172) alignment 
Range on Protein: 461-625
Range on HMM: 9-160/172.0
DGFDLDLTYITPNIVAMGYPaegteavYRNRYEDTLRFLEERHPGAyrVYNLCSE--RAYPPSRFHNRVGVYPFDDHNPAPLPLVLACCADIHAWLaANP
. ..|||.||.....|. .|       .|| ..| .|.| |.. ..  ..||...   ... .|.  ..  .|..||.. .| |.| ..  |. .| |. 
nasyldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidell.als

ERNVAAIHCKAGKGRTGLIISCYLMYagICPDPDSAMTMFGAKRthnGKGVTIPSQRRYIRYFHTML
. .. ..||.||.||||... .|||.   . ... |. .. .||   ...|..|||.|...||. .|
pggpvlVHCsaGvgRtgtlvaaylml..lglsleeavalvrekR...pgavqnpsqyrflyyfekll
0041856 (Phosphotyrosine protein) phosphatases II 461-625 3.6e-28 93.8 In-house 13-170 (182) alignment 
Range on Protein: 461-625
Range on HMM: 13-170/182.0
DGFDLDLTYITPNIVAMGYPAEGTEAVYRNRYEDTLRFLEERHPGAY-RVYNLCsERAYPPSRFHN---RVGVYPFDDHNPAPlplVLACCADIHAWLAa
  ...||.||..|......||   .| ... .... .||.  .   .  . ||. |. |.|.....   ..  .|..||.. .   .  ... |...|. 
ydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpd...ldelldfieevle.

npERNVAAIHCKAGKGRTGLIISCYLMYAGiCPDPDSAMTMFGAKRTHngkGVTIPSQRRYIRYFHTML
  | .. ..||.||.|||| .. .|||.     ....|. ..  .| .   .|..|.| ......  .|
..eggpvlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrRpg...mvitpnqyfflqlallel
0045098 (Phosphotyrosine protein) phosphatases II 461-625 2e-23 78.6 In-house 3-271 (278) alignment 
Range on Protein: 461-625
Range on HMM: 3-271/278.0
DGFDLDLTYITPNIVAMGYPAEGTEAVYRNRYE-------------------------------------------------------------------
....|||.... .....|.| | |.|.|.. ..                                                                   
alasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelg

------------------------DTLRFlEERHPGAYRVYNLCSERAYPPSRFHNRVGVYPFDDHNPAPLP---LVLACCADIHAWLA-----------
                        .. .. .. .   ..|.||..||.. .||. . .  .|..||.. .||    .| ..  |...|.           
rekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssll

ANPERNVAAIHCKAGKGRTGLIISCYLMYAGI--CPDPDSAMTMFGAKRthNGKGVTIPSQRRYIRYFHTML
.... .. ..||.||.|||| .. .|||.  .    |...| ...  .|  .|  |....| |.. .|. .|
lldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqR..pglavqnleqyrflyefllel
0046845 (Phosphotyrosine protein) phosphatases II 461-622 5.8e-22 73.8 In-house 66-270 (284) alignment 
Range on Protein: 461-622
Range on HMM: 66-270/284.0
DGFDLDLTYITPNIVAMGYPAEGT-----------------------------EAVYRNRYEDTLRF-------LEERHPGAYRVYNLCSERA--YPPSR
||.|||||||.....|. .| ..|                              | |.. ....|..       |.| . . | |..|. ..     .||
dgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesr

FHNRVGVYPFDDHNPAP-LPLVLACCADIHAWLAANPERNVAAIHCKAGKGRTGLIISCYLMYAGI-------CPDPDSAMTMFGAKRTHngkGVTIPSQ
...   . .. ||.  | .  .|. . ... .| ..|  .. ..||.||.|||| .| ..|..  .       ..|. .|. ..  .| .    |. ..|
tvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpg...mvqtleq

RRYIRYFH
 |.. .. 
yrfvyeal
0036941 (Phosphotyrosine protein) phosphatases II 461-625 1.7e-15 52.6 In-house 72-276 (297) alignment 
Range on Protein: 461-625
Range on HMM: 72-276/297.0
DGFDLDLTYI---------------------TPNIVAMG-------------YPAEGTEAVYRNRYedTLRFLEERH--PGAYRVYNLCSER-AYPPSRF
||.||. ..|                     .. || .              .| |  | .. ...  |...|.. .   . | ...|. .   ...||.
dgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdf..tvtllsvevvllddytlrtlevtdtgngesrt

HNRVGVYPFDDHNPAP-LPLVLACCADIHAWLAANPERNVAAIHCKAGKGRTGLIISCYLMY-------AGICPDPDSAMTMFGAKRTHngkGVTIPSQR
 .   .   .||.. .    .|. .  .. .|.. |. ..  .||.||.||.| .| ..||.          ..|. .|. ..  .| .    |. ..| 
vthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpg...avqtleqy

RYIRYFHTML
|.....  .|
rflyeallel
0036282 (Phosphotyrosine protein) phosphatases II 462-627 1e-40 134.6 In-house 7-171 (174) alignment 
Range on Protein: 462-627
Range on HMM: 7-171/174.0
GFDLDLTYITPNIVAMGYPAEGTEAVYRNRYEDTLRFLEERHPGAYRVYNLCSERAYPPSRFHNRVGVYPFDDHNPAPLPLVLACCADIHAWLAAnPERN
 ..|||.||||...|...|..  | ..... .. ...|||...| |...|...|. . ..|.. ..  .|..||.. .|. .| ..  .. .|.  .. .
aspldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealse.dpgg

VAAIHCKAGKGRTGLIISCYLMYAGICPDPDSAMTMFGAKRTHNGKGVTIPSQRRYIRYFHTMLQG
. ..||.||.||||... .|||. |...... |. .. ..|......|..|||.|...||. .|.|
pvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekllsg
subfamily_Auxilin_pd Subfamily Auxilin 464-626 4.2e-42 136.7 In-house 8-165 (166) alignment 
Range on Protein: 464-626
Range on HMM: 8-165/166.0
DLDLTYITPNIVAMGYPAEGTEAVYRNRYEDTLRFLEERHPGAYRVYNLcSERAYPPSRFHNRVGVYPFDDHNPAPLPLVLACCADIHAWLAANPeRNVA
|||..|||  |. | .||||.|  |.|  .|   ||| |||. | |||| |.| |.......||  . .  ..  .|  ... |.....|| ..| .|| 
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynl.sqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdp.knvv

AIHCKAGKGRTGLIISCYLMYAGICPDPDSAMTMFGAKRTHNGkgvTIPSQRRYIRYFHTMLQ
 .||| |.  .....| .|... . ..|.||...| .||.  |     ||..||. |.  .|.
vvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig...lspsekryleyladlla
0049772 (Phosphotyrosine protein) phosphatases II 464-626 2.1e-21 72.4 In-house 118-278 (314) alignment 
Range on Protein: 464-626
Range on HMM: 118-278/314.0
DLDLTYITP---------------------NIVAMGYPaegteavyrnryedtlrfleeRHPGAYRVYNLCsERAYPPSRFHNRVGVY---PFDDHNPAP
||.. .| .                     .. ..|..                      .| | .. .|. |. |.|..| ...  |   |..|... .
dlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....................neptaadlellk.eelydpelferlgikylripvpDgsapl

LPLVLACCADIHAWlaanPERNVAAIHCKAGKGRTG-LIISCYLMYAGICpDPDSAMTMFGAKRTHNGKGVTIPSQRRYIRYFHTMLQ
|  ...... |...    .. .. ..|||||||||| ... .|||..  . ... |. .. .||. | . ..|.....|. ... .|.
ledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnpgfieqleqyefilealle
0051082 (Phosphotyrosine protein) phosphatases II 465-622 6.7e-26 86.1 In-house 6-148 (151) alignment 
Range on Protein: 465-622
Range on HMM: 6-148/151.0
LDLTYITPNIVAMGYPAEgteavyrnryeDTLRFLeeRHPGAYRVYNLCS--ERAYPPSRFHN---RVGVYPFDDHNPAPLPLVLACCADIHAWLAAnPE
....|.|... ..|.| .           | |..|  .. | . ..||.|  ||.| |.....   .|  .|..|. . .||| .. ..... .|.. ..
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld.kk

RNVAAIHCKAGKGRTGLIISCYLMYAGicPDPDSAMTMFGAKRThngkGVTIPSQRRYIRYFH
 .. ..||.|||||||... .|||. |   ....|. .. .||.    ||..|.| ... .|.
ngpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp....gvvqpnqqflfqlfa
0038934 (Phosphotyrosine protein) phosphatases II 469-606 4.2e-30 100.2 In-house 15-160 (194) alignment 
Range on Protein: 469-606
Range on HMM: 15-160/194.0
YITPNIVAMGYPAEG-----TEAVYRNRYEDTLRFLEERHPGAYRVYNLC-SERAYPPSRFHN---RVGVYPFDDH-NPAPLPLVLACCADIHAWLAANP
.||....|...|..|     .| .||. .|| .|.|.... . . |..|. .|| | |..|..   ..  .|| |. .. .| ..|  .  .. .|...|
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

ErNVAAIHCKAGKGRTGLIISCYLMYAGICpDPDSAMTMFGAKRTHNG
. .| |.|||||.||||... .||.|   . ... |. .|  || .  
g.gvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekRpgai
0049260 (Phosphotyrosine protein) phosphatases II 475-626 5.5e-29 96.2 In-house 5-150 (152) alignment 
Range on Protein: 475-626
Range on HMM: 5-150/152.0
VAMGYPAEGTEAVYRNRYEDTLRFLEERHPGAYRVYNLCSERAYPPSRFHNRVGVYPFDDHNPAPLPLVLACCADIHAWLaANPERNVAAIHCKAGKGRT
.||.... .|.....| ..| .|.| | . ... ... ..|....   .. ..  .|..||.. .|. .|  . ... .| |  . .. ..||.||.|||
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRt

GLIISCYLMYagICPDPDSAMTMFGAKRthnGKGVTIPSQRRYIRYFHTMLQ
|... .|||.     ... |. .. .||    ..|. |.|.|.. .|...|.
gtlvaaylml..lgvsleeavalvrekR...pgavpnpgqlrflyefekllk
0048076 (Phosphotyrosine protein) phosphatases II 479-626 1.2e-23 78.8 In-house 3-143 (145) alignment 
Range on Protein: 479-626
Range on HMM: 3-143/145.0
YPAEGTEAVYRNRYEDTLRFLEERHPGAYRVYNLCSERAYPPsRFHNRVGVYPFDDHNPAPL-PLVLACCADIHAWLAANperNVAAIHCKAGKGRTGLI
.|.| .. .|.. . ..|.. . .. | ..|.||.||. ..  |.. ..  .|..||.. .|  |.|.... |...|...   .. ..||.||.||||..
wpseilpglylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeg...gpvlVHCsaGvgRtgtl

ISCYLMYAgICPDPDSAMTMFGAKRTHngkGVTIPSQRRYIRYFHTMLQ
. .|||.     ....|. .. ..| .   .|. |.|.|....|...|.
vaaylmll.lgvsleealelvrsqrpg...avpnpgqlrflyefelell
0048179 (Phosphotyrosine protein) phosphatases II 479-624 1.5e-22 75.3 In-house 3-143 (144) alignment 
Range on Protein: 479-624
Range on HMM: 3-143/144.0
YPAEGTEAVYRNRYEDTLRFLEERHPGAYRVYNLCSErAYPPSRFHN--RVGVYPFDDHNPAPL-PLVLACCADIHAWLAANperNVAAIHCKAGKGRTG
.|.| .. .|.. . ..|.. . .. | . |.||..|  .|..  ..  ..  .|..||.. .|  |.|.... |...|. .   .. ..||.||.||||
npseilpglylgslptaldlellkklgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieealeeg...gpvlVHCsaGvgRtg

LIISCYLMYAGIcPDPDSAMTMFGAKRThngKGVTIPSQRRYIRYFHTM
... .|||.     ....|. .. ..|     .|. |.|.|........
tlvaaylmkklg.lsleealalvrsrrp...gavpnpgqlrfLleyekl
0051429 (Phosphotyrosine protein) phosphatases II 480-605 5.7e-11 38.1 In-house 76-207 (272) alignment 
Range on Protein: 480-605
Range on HMM: 76-207/272.0
PAEGTEAVYRNRYEDTLRFLEERHPGAYRVYNLCSERAYPPSRFhNRVGVYPFDDHNPAPLPLvlACCADIHAWLAAnpeRNVAAIHCKAGKGRTGLIIS
| ....|   . .  ....|.| .   | ...|. .. ....    .| .. . |    . |     . .. ..|..    .   .||.|||.|||... 
pilddsaptilygalrvtllseellldyilrellltlllsagea.revmhlhytdwpdhgvpq..eallellellld...ggpvlvHCsaGkdRTGtvva

CYLMYAGICPD------------PDSAMTMFGAKRTHN
..|...|.. .            .. |. .  |.| . 
llllllgvsletivddYlltnlyleeaveelraqrpga
0047943 (Phosphotyrosine protein) phosphatases II 495-621 1.6e-19 65.9 In-house 138-267 (273) alignment 
Range on Protein: 495-621
Range on HMM: 138-267/273.0
TLRFLEERHPGAYRVYNLCSER-AYPPSRFHNRVGVYPFDDHNPA-PLPLVLACCADIHAWLAANPERNVAAIHCKAGKGRTGLIISCYLMY----AGIC
| ..|.| . . | |..|. ..  .. ||. . . .... ||.    |  .| .. ... .|.|.|. .. ..||.||.|||| .| ..|..    .. .
tvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekegg

PDPDSAMTMFGAKRTHngkGVTIPSQRRYIRYF
.|...|. ..  .| .   .|. |.|.|.. ..
vdvleavkllrsqRpg...mvqtpeqyrflyea
0051299 (Phosphotyrosine protein) phosphatases II 495-619 3.7e-15 51.6 In-house 150-279 (288) alignment 
Range on Protein: 495-619
Range on HMM: 150-279/288.0
TLRFLEERHPGAYRVYNLCSERA--YPPSRFHNRVGVYPF----DDHNPAPLPLVLACCADIHAWLAanPERNVAAIHCKAGKGRTGLIISCYLMY----
| ..|.| . . | |..|. ..   . .. .. .| .. .    |.. |  . |.|. . ... .||  .  .. ..||.||.|||| .| ..|..    
tvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqle

AGICPDPDSAMTMFGAKRTHngkGVTIPSQRRYIR
.. ..|. .|. ..  .| .    |. |.| |.. 
keggvdvleavkrlreqRpg...mvqtpeqyrfvy
0050432 (Phosphotyrosine protein) phosphatases II 496-618 5.2e-11 37.9 In-house 170-291 (308) alignment 
Range on Protein: 496-618
Range on HMM: 170-291/308.0
LRFLEERHPGAYRVYNLCSERAYPPSRFHNRVGVYPF--DDHNPAPLPLVLACCADIHAWLaanpERNVAAIHCKAGKGRTGLIISCYLM----YAGICP
...|.| . . | |..|. .    .  .. ..  |.   |.. |  .  .|. .  .. .|    . .. ..||.|| |||| .| ..|.     .. ..
vtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggv

DPDSAMTMFGAKRTHngkGVTIPSQRRYI
|. .|. ..  .| .    |. |.| ...
dvfeavkklReqRpg...mvqtpeqylfl
0048567 (Phosphotyrosine protein) phosphatases II 531-585 8.8e-07 23.4 In-house 44-102 (157) alignment 
Range on Protein: 531-585
Range on HMM: 44-102/157.0
PFDDHNPAPLPLVLACCADIHAWLAANP-ERNVAAIHCKAGK---GRTGLIISCYLMYA
.| |. | .| ..   .  .. .|     .... |.|||||    |||...|.|||.. 
fffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilh
PTPc_DSPc_SM00012 535-590 1.2e-06 24.0 In-house 14-69 (105) alignment 
Range on Protein: 535-590
Range on HMM: 14-69/105.0
HNPAPLPLVLACCADIHAWLAANPERNVAAIHCKAGKGRTGLIISCYLMYAGICPD
. | .   .|  ..... .  .. ...   .||.|| |||| ..  ....  ..  
gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleke
subfamily_PTPDC1_pd Subfamily PTPDC1 560-604 9e-11 36.5 In-house 114-157 (182) alignment 
Range on Protein: 560-604
Range on HMM: 114-157/182.0
RNVAAIHCKAGKGRTGLIISCYLMYAGICpDPDSAMTMFGAKRTH
..  |.|| ||.||||..|.|||.||    ... |...  .||..
egkvavhChaGlGrtGvliacylvyakrl.taekaiklvrskrpk
subfamily_CDC14_pd Subfamily CDC14 562-584 2.1e-07 25.1 In-house 265-287 (328) alignment 
Range on Protein: 562-584
Range on HMM: 265-287/328.0
VAAIHCKAGKGRTGLIISCYLMY
 .|.||||| |||| .|.||||.
aiavhCkaGLGrtGtLiacylmk
DSPc Dual specificity phosphatase, catalytic domain 562-605 2.4e-06 22.4 Pfam-A 75-117 (133) alignment 
Range on Protein: 562-605
Range on HMM: 75-117/133.0
VAAIHCKAGKGRTGLIISCYLMYAGICpDPDSAMTMFGAKRTHN
  ..||.||  |.. .| .|||.   . . ..|. ..  .| . 
kvlVHCqaGisRSatliiaYlmktknl.slneAyefvkerrski
DSPc Dual specificity phosphatase, catalytic domain 562-605 2.4e-06 22.4 In-house 75-117 (133) alignment 
Range on Protein: 562-605
Range on HMM: 75-117/133.0
VAAIHCKAGKGRTGLIISCYLMYAGICpDPDSAMTMFGAKRTHN
  ..||.||  |.. .| .|||.   . . ..|. ..  .| . 
kvlVHCqaGisRSatliiaYlmktknl.slneAyefvkerrski
subfamily_PTPMT1_pd Subfamily PTPMT1 563-605 2.8e-08 28.4 In-house 110-151 (171) alignment 
Range on Protein: 563-605
Range on HMM: 110-151/171.0
AAIHCKAGKGRTGLIISCYLMYAGICpDPDSAMTMFGAKRTHN
  .|||||.||.. ...||||.   . .|..|...  .|| . 
vYvHCkaGrgRsatlvacylmkkekl.speeAlkalkkkRkii
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 633-765 2.8e-24 76.8 Pfam-A 2-133 (134) alignment 
Range on Protein: 633-765
Range on HMM: 2-133/134.0
PATPLTLTGIRLHGVPNYDFSGGCQPYYQVYQEGVLIFsSKPAELRQLQAYkRQTHRDIRFSCNMAIEGNIRIELWDCDRGFHSEEKMFAATFFTGMVE-
. ..|.|..|.|.|.||.. .|||.|. .||.. . .| ...|. .. . . |. .  . .. .. .|| ...|. . |    ..||.| . | | ..| 
npkrlelksiilegiPnfktrggckpkvkvyngkkkvf.kelasykdster.raktfivkepnrlpveGDvlveflhkdsklpkkekifrvwFNTsFiek

-GTSLRMVRQELDGAHKKKhLKMFEPQFAMELTFK
  . | . ..|||.|.|.|  | |...|..|| |.
nqnvltlpkneLDkalkdk.dkkfsknfkvelvfe