Gene PTEN-2 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily PTEN
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP029_AA protein Get Run
MbreP029_AA_2-187 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0037934 (Phosphotyrosine protein) phosphatases II 3-181 1.4e-29 98.7 In-house 3-240 (243) alignment 
Range on Protein: 3-181
Range on HMM: 3-240/243.0
TIAKHLVSKKKRRFM--------------DEGFDLDLTFITRNIVAMGFPAEGRE---------GIYRNHMRDVK-------------------------
.||.......|.|..              .  ....|. .|... |...| ..            ..... . .                          
siallpenlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygd

---RFFDYRCKDHYRVYNLCSER--DYDPQKFYGRVAKYPFDDHNAPP-FLLMQPFCEDVHQYLSE-------DSRNVAVIHCKAGKGRTGVMISAYLMH
   .. ... .|.| |..|. |.   .|....  ..  .|. ||..|. .  .. |...|.....|       || .. ..||.||.||||..| ||||.
ftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylml

CGLFEKTEEALEFYGHARTMngKGVTIPSQVRYVHYYGRY
  |    |||....   | .  |.|..||| |..... ..
lllgvdleeavkllreqRpg..kavqtpsqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 3-183 4.5e-28 93.9 In-house 36-276 (317) alignment 
Range on Protein: 3-183
Range on HMM: 36-276/317.0
TIAKHLVSKKKRRF-------------MDEGFDLDLTFI----------TRNIVAMGFPAEG-----REGIYRNHMRDVKRFFDYR--------------
..|.....|.|.|.              ..|.|||...|          .|...|...| ..      . ..... . . .. .                
svaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplg

----------------CKDHYRVYNLCSERDYDPQKFYGRVAKYPF-DDHNAPP-FLLMQPFCEDVHQYLSeDSRNVAVIHCKAGKGRTGVMISAYLMH-
                 .... ...|. | ..|..... ..  |.. .||..|| . |.. |.| |...|. |. .. ..||.||.||||..| ||||. 
etltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmle

----CGlFEKTEEALEFYGHARtmnGKGVTIPSQVRYVHYYGRYVR
     | .   |||.... ..|   ...|. |.| |..... ..  
qlekeg.gvdveeavkelreqR...pgavqtpeqyrflydalleyl
subfamily_VSP_pd Subfamily VSP 4-180 1e-64 212.3 In-house 15-196 (212) alignment 
Range on Protein: 4-180
Range on HMM: 15-196/212.0
IAKHLVSKKKRRFMDEGFDLDLTFITRNIVAMGFPAEGREGIYRNHMRDVKRFFDYRCKDHYRVYNLCSERDYDPQKFYGRVAKYPFDDHNAPPFLLMQP
.|..|||. |||.. .|||||||..|  |.|| ||. |.. .||| ...| ||.| . .|||.|.||||||.||.. |  || .   |||| | .  .  
aarrlvsenkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellv

FCEDVHQYLSEDSRNVAVIHCKAGKGRTGVMISAYLMHCGLFEKTEEALEFYGHARTMNG-----KGVTIPSQVRYVHYYGR
|...|...|..| .|| .|||| |||||| .. |.|.. ..||...|.|...|. || ..     .||  ||| |||.|.  
ftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleq
0039614 (Phosphotyrosine protein) phosphatases II 4-182 6.1e-32 106.7 In-house 50-288 (297) alignment 
Range on Protein: 4-182
Range on HMM: 50-288/297.0
IAKHLVSKKKRRFM--------------DEGFDLDLTFI-----------TRNIVAMGFPAEGREGIYRNHMRDVK------------------------
||.. ..|.|.|..               .|.|||...|           ||...|...| ..  . . . ... .                        
iallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpee

---------RFFDYRCKDHYRVYNLCSERdYDPQKFYGRVAKYPFDDHNAPP-FLLMQPFCEDVHQYLSED-SRNVAVIHCKAGKGRTGVMISAYLMH--
         .. ..  .|.| |..|. .. ... ... ..  ... ||..|| . |.. |.| |...|.|. . .. ..||.||.||||..| ||||.  
ggtygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleq

--CGLFEKTEEALEFYGHARtmnGKGVTIPSQVRYVHYYGRYV
  ..     .||....  .|   ...|..||| |..... .. 
lekeggvdvleavkelreqR...pgavqtpsqyrflydallel
0042113 (Phosphotyrosine protein) phosphatases II 4-179 8.8e-29 96.0 In-house 3-239 (245) alignment 
Range on Protein: 4-179
Range on HMM: 3-239/245.0
IAKHLVSKKKRRF-------------MDEGFDLDLTFI----------TRNIVAMGFPAEGREG-----IYRNHMRDVK---------------------
.|.....|.|.|.             ...|.|||...|          |... |...|...  .     ..... . .                      
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

---------RFFDYRCKDHYRVYNLCSER-DYDPQKFYGRVAKYPFDDHNAPP-FLLMQPFCEDVHQYLSEDSRNVAVIHCKAGKGRTGVMISAYLMH--
         .. ..  .|.| |..|. ..  .|....  ..  .|..||..|.   |.. |.| |...|.||| .. ..||.||.||||..| ||||.  
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

--CGLFEKTEEALEFYGHARtmnGKGVTIPSQVRYVHYYG
    |    |||....   |   .. |..||| |..... 
lekelgvsleeavkelrsqR...pgavqtpsqyrflyeal
0045450 (Phosphotyrosine protein) phosphatases II 4-179 1.1e-28 96.4 In-house 49-300 (307) alignment 
Range on Protein: 4-179
Range on HMM: 49-300/307.0
IAKHLVSKKKRRFMD-------------------------------------EGFDLDLTFI----------------------------------TRNI
||.....|.|.|..|                                     .|.||...||                                  .|..
iallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrek

VAMGFPAEGREGIYRNhmrDVKRFFDYRCKDHYRVYNLCSERdYDPQKFYGRVAKYPF---DDHNAPP-FLLMQPFCEDVHQYLSED-SRNVAVIHCKAG
 |. .| || |  |.|   .. .. ..  .|.| |..|. .. .|. ..  .|  ...    ||..|| |  .  |.| |...|.|. . .. ..||.||
caqywPdegeeltygn...ftvtllseehldgytvrtlevtd.ldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaG

KGRTGVMISAYLMHCGLF-------EKTEEALEFYGHARtmnGKGVTIPSQVRYVHYYG
.||||..| |||| ..|           .||....   |   ...|. |.| |..... 
vgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR...pgavqnpeqyrflyeal
0043336 (Phosphotyrosine protein) phosphatases II 4-178 1.5e-28 95.5 In-house 39-272 (278) alignment 
Range on Protein: 4-178
Range on HMM: 39-272/278.0
IAKHLVSKKKRRF-------------MDEGFDLDLTFI----------TRNIVAMGFPAEGREGIYRNHMRDVK--------------------------
||... .|.|.|.              ..|.|||...|          .|...|...| .. .. ... ... .                          
iallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggs

--------RFFDYRCKDHYRVYNLCSERDYDPQKFYGRVAKY-PFDDHNAP-PFLLMQPFCEDVHQYLSeDSRNVAVIHCKAGKGRTGVMISAYLMH---
        .. ..  .|.| |..|. .. .|........  | .. ||..| .. |.. |...|...|. || .. ..||.||.||||..| .||..   
ltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleql

-CGLFEKTEEALEFYGHARtmnGKGVTIPSQVRYVHYY
  ...   |||.... . |   .. |. ||| |.....
ekeggvdleeavkelreqR...pgavqtpsqyrflyea
0040439 (Phosphotyrosine protein) phosphatases II 4-179 2.7e-27 91.4 In-house 5-242 (249) alignment 
Range on Protein: 4-179
Range on HMM: 5-242/249.0
IAKHLVSKKKRRFM---------------DEGFD--------LDLTFITRNIVAMGFPAEGREGIYRNHMRDVK--------------------------
.|.....|.|.|..               ...|.        .|.. |.|...|...| ..  . ... ... .                          
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplgg

---------RFFDYRCKDHYRVYNLCSERDYDPQKFYGRVAKY-PFDDHNAP-PFLLMQPFCEDVHQYLSED-SRNVAVIHCKAGKGRTGVMISAYLMHC
         .....  ||.| |..|. .. ||..... ..  | .. ||..|  |  .  |.| |...|.|. . .. ..||.||.||||..| ||||..
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmle

GL-FEKTEEALEFYGHARTMNGKGVTIPSQVRYVHYYG
 |  |..  ..| . . |.. ...|. |.| |..... 
qlekelgvdleeavkllrsqRpgavqnpeqyrflyeal
0046845 (Phosphotyrosine protein) phosphatases II 4-178 6.6e-24 80.2 In-house 22-269 (284) alignment 
Range on Protein: 4-178
Range on HMM: 22-269/284.0
IAKHLVSKKKRRFMD-----------------------------EGFDLDLTFITRNIVAMGFPAEG-----------------------------REGI
.|...  ..| |..|                             .|.||||| |.....|. .| ..                                 
vallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaq

YRNHMRDVKRF-------FDYRCKDHYRVYNLCSERDY-DPQKFYGRVAKY-PFDDHNAPP-FLLMQPFCEDVHQYLSE-DSRNVAVIHCKAGKGRTGVM
|.... .|...        ..  ||.| |..|. ..   . . .. ..  | .. ||..|| .  .. |...|...|.. .. .. |.||.||.||||..
YwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtf

ISAYLMHCGLFEK----TEEALEFYGHARTMNGKGVTIPSQVRYVHYY
| ..|... | ..    .  .|| . . |..    |. ..| |.|...
ialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyea
subfamily_PTEN_pd Subfamily PTEN 5-186 1e-85 281.3 In-house 2-183 (184) alignment 
Range on Protein: 5-186
Range on HMM: 2-183/184.0
AKHLVSKKKRRFMDEGFDLDLTFITRNIVAMGFPAEGREGIYRNHMRDVKRFFDYRCKDHYRVYNLCSERDYDPQKFYGRVAKYPFDDHNAPPFLLMQPF
 ...|||||.|| ..|.||||..||.||.|||.|||. |..|||...||..|.. ..||||..|||.|||.|| .|| ||||.|||||||.||. |....
lrkivskkkkrfkedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleei

CEDVHQYLSEDSRNVAVIHCKAGKGRTGVMISAYLMHCGLFEKTEEALEFYGHARTMNGKGVTIPSQVRYVHYYGRYVREQR
.||....|.||..||.|.|||||||||||.|.|||....|.||.|||||.. .||| |.|||||||| |||.|| ....|..
vediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyeklleeek
0044763 (Phosphotyrosine protein) phosphatases II 9-187 8.1e-24 79.6 In-house 7-175 (178) alignment 
Range on Protein: 9-187
Range on HMM: 7-175/178.0
VSKKKRRFMDEGFDLDLTFITRNIVAMGFPAegregiyrnhMRDVKRFFDYRCKdhyRVYNLCSE--------RDYDPQKFYGRVAKYPFDDHNAPP-FL
|.  ... .  .. .....|. .. ....|.           .|.. . .. ..    . ||..|          |.|...  .. ..|..||..|. . 
vllsnleglersdyinaseilpglylgslpp..........addlellkelgit...hivnlteelelgflkcdpywpeeagiqylhipipDhgvpdlle

LMQPFCEDVHQYLSEDSRNVAViHCKAGKGRTGVMISAYLMHCGlfekTEEALEFYGHARTMNGkGVTIPSQVRYVHYYGRYVREQRE
 .. |.| ....|.|. ..|.| ||.||.||.|... ||||..        . | . . | .   .|. |.|.|..... ........
hflefvefieealdekggpvlV.HCsaGvgRsgtlvaaylmkkl....glsleeaielvrerRp.ivpnpgqlrqLyefelrllkesd
0036941 (Phosphotyrosine protein) phosphatases II 10-178 1.8e-19 65.6 In-house 39-272 (297) alignment 
Range on Protein: 10-178
Range on HMM: 39-272/297.0
SKKKRRFMD------------------------EGFDLDLTFI---------------------TRNIVAMG-------------FPAEGREGIYRNHMR
 ..| |..|                        .|.||. .||                     .. || .              .| | .| .. ....
nleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdft

DVKRFFDYRCKDHYRVYNLCSERDYDPQKFYGRVAKYP-FDDHNAPP-FLLMQPFCEDVHQYLSED-SRNVAVIHCKAGKGRTGVMISAYLMHCGL----
   . ...  .|.| ...|. .   ...... ..  |.  .||..|. .  .  |.| |...|..  | .. ..||.||.||.|..| |.||.. |    
vtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledkl

FEKTEEALEFYGHARTMNGKGVTIPSQVRYVHYY
 |..   ||.. . |..    |. ..| |.....
keggvdileavkklReqRpgavqtleqyrflyea
PTEN_1 11-182 4.8e-45 148.8 In-house 8-192 (196) alignment 
Range on Protein: 11-182
Range on HMM: 8-192/196.0
KKKRRFMDEGFDLDLTFITRNIVAMG-FPAEG-----REGIYRNHMRDVKRFFDYRCKDH-YRVYNLCSERD-----YDPQK-FYGRVA--KYPFDDHNA
 .|..  .....||||.||. |.||| .|...      || ||....|| ...| . .|. . |.||..|..     ||... | ..|   ..|..||.|
sskknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhga

PPFLLMQPFCEDVHQYLSEDS-RNVAVIHCKAGKGRTGVMISAYLMHCGLfEKTEEALEFYGHARTMNGKGvtIPSQVRYVHYYGRYV
|..  .. .|......|..|. .||...|||||.||.|... ||||..|     .||||..  .|. ...   .||| |...|. .  
pslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn..spsqerlleyfaell
0041856 (Phosphotyrosine protein) phosphatases II 12-185 8.9e-31 102.3 In-house 3-173 (182) alignment 
Range on Protein: 12-185
Range on HMM: 3-173/182.0
KKRRFMD---EGFDLDLTFITRNIVAMGFPAEGREGIYRNHMRDVKRFFDYRCKDHYR-VYNLCsERDYDPQKFYG---RVAKYPFDDHNAPPFLLMQPF
.|.|..|     ...||..|. |......||   .  .......| .|...  . ... . ||. |. |.|....    .. ..|..||..|..  .  |
dknrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpdldelldf

CEDVHQylsedSRNVAVIHCKAGKGRTGVMISAYLMHCGlFEKTEEALEFYGHARtmnGKGVTIPSQVRYVHYYGRYVREQ
.|.|..     . .. ..||.||.||||... ||||..      |||....  .|    ..|..|.| ...... ......
ieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrR...pgmvitpnqyfflqlallellll
subfamily_Tensin_pd Subfamily Tensin 14-199 3.8e-42 136.9 In-house 2-188 (189) alignment 
Range on Protein: 14-199
Range on HMM: 2-188/189.0
RRFMDEGFDLDLTFITRNIVAMGFPAEGREGIYRNHMRDVKRFFDYRCKDHYRVYNLcSERDYDPQKFYGRVAKYPFDDHNAPPFLLMQPFCEDVHQYLS
 |...| .|||||.||  |.|. ||||| |  ||....|| .... . .|.|.|.|| ||. || .|.  .|  . . |. ||..  .   |......|.
vryveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnl.sekrydisklnkkvldfGWPdllaPsleklcsicksldsWlk

EDSRNVAVIHCKAGKGRTGVMISAYLMHCGLFEKTEEALEFYGHARTMNGK--GVTIPSQVRYVHYYGRYVREQREFEPIPLIMKRII
.| .||.|.||| ||||.||..|||. .  . . ...||. .   | .. |  |.| ||| |||.|.  ..  . ...  ||... .|
adpqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkiklnssplflhyvi
0046846 (Phosphotyrosine protein) phosphatases II 15-183 1.8e-33 111.1 In-house 2-173 (176) alignment 
Range on Protein: 15-183
Range on HMM: 2-173/176.0
RFMDEGFDLDLTFITRNIVAMGFPAEGREGIYRNHMRDVKRFFDYrckDHYRVYNLCSERDYD----------PQKFYGRVAKYPFDDHNAPPFLLMQPF
|..  |.||||..|. |......|. . ....|... ........   ... | ||..|....           .|.  ..  .|..||..|.. |.. .
rlrllgldldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllel

CEDVHQYLSEDsrNVAVIHCKAGKGRTGVMISAYLMHCGLFEKTEEALEFYGHARTMngKGVTIPSQVRYVHYYGRYVR
.| ....|.|.  .. ..||.||.||||... |||.... . . ||||...   | .  . |. |.|.|..... ....
lefirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl..gavqtpeQyrflyefellll
0043147 (Phosphotyrosine protein) phosphatases II 20-183 2.3e-31 104.2 In-house 10-161 (172) alignment 
Range on Protein: 20-183
Range on HMM: 10-161/172.0
GFDLDLTFITRNIVAMGFPaegregiYRNHMRDVKRFFDYRCKDHyrVYNLCsERDYDPQKFY---GRVAKYPFDDHNAPPFLLMQPFCEDVHQYLSEDS
 ..|||..|.....|. .|       .||.. |. |..  .  .|  ..||. |. |||....    ..  .|..||..|.. |.. |.| ....| ...
asyldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnlt.ellydpellerlgiqylylpwpDhgvpllellleflefidellalsp

RNVAVIHCKAGKGRTGVMISAYLMHCGLfeKTEEALEFYGHARtmnGKGVTIPSQVRYVHYYGRYVR
 .. ..||.||.||||... ||||..||  . |||.... ..|   ...|..||| |...|. ....
ggpvlVHCsaGvgRtgtlvaaylmllgl..sleeavalvrekR...pgavqnpsqyrflyyfeklll
0045098 (Phosphotyrosine protein) phosphatases II 20-185 1.1e-27 92.6 In-house 4-274 (278) alignment 
Range on Protein: 20-185
Range on HMM: 4-274/278.0
GFDLDLTFITRNIVAMGFPAEGREGIYRNHMR--------------------------------------------------------------------
...|||. .. .....|.| |  ...|....                                                                     
lasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgr

-----------------------DVKRFfDYRCKDHYRVYNLCSERDYDPqKFYGRVAKY-PFDDHNAPPFL---LMQPFCEDVHQYLS-----------
                       ..... |. .. ...|.||..|| ... ... .. .| |..||..|..     .. ..| ....|.           
ekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredle.srgvthlhylpwpdhgvpslpilksflellefirealkllaslllssll

-EDSRNVAVIHCKAGKGRTGVMISAYLMHCGLfEKTEEALEFYGHARTMNGK-GVTIPSQVRYVHYYGRYVREQ
 .|| .. ..||.||.||||... |||| . | |..  .|| . . |.. .   |....| |..... ......
lldsggpvlVHCsaGvgRtGtlvaaylmlell.eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0036282 (Phosphotyrosine protein) phosphatases II 21-182 7.5e-43 141.6 In-house 8-169 (174) alignment 
Range on Protein: 21-182
Range on HMM: 8-169/174.0
FDLDLTFITRNIVAMGFPAEGREGIYRNHMRDVKRFFDYRCKDHYRVYNLCSERDYDPQKFYGRVAKYPFDDHNAPPFLLMQPFCEDVHQYLSEDSRNVA
..|||. ||....|...|..  | ..... ..| .. . . ...|...|...|. .|. ..  .. ..|..||..|..  .. |.. |...||||. .. 
spldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpv

VIHCKAGKGRTGVMISAYLMHCGLFEKTEEALEFYGHARTMNGKGVTIPSQVRYVHYYGRYV
..||.||.||||... ||||..||.|....||...  .|......|..||| |...|.....
lVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
subfamily_Auxilin_pd Subfamily Auxilin 22-182 8.7e-41 132.4 In-house 8-164 (166) alignment 
Range on Protein: 22-182
Range on HMM: 8-164/166.0
DLDLTFITRNIVAMGFPAEGREGIYRNHMRDVKRFFDYRCKDHYRVYNLcSERDYDPQKFYGRVAKYPFDDHNAPPFLLMQPFCEDVHQYLSEDSRNVAV
|||...||  |. | ||||| |  |.|.. ||. | . | ...| |||| |.|.|...|. .|| .. .  ..||.   .   | .....| .|..|| |
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynl.sqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvv

IHCKAGKGRTGVMISAYLMHCGLFEKTEEALEFYGHARTMNGkgvTIPSQVRYVHYYGRYV
.||| |.  ..|..||.|..| |....|.|....   |.  |     ||. ||..| .  .
vhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig...lspsekryleyladll
0049772 (Phosphotyrosine protein) phosphatases II 22-181 2e-25 85.6 In-house 118-276 (314) alignment 
Range on Protein: 22-181
Range on HMM: 118-276/314.0
DLDLTFITR---------------------NIVAMGFPaegregiyrnHMRDVKRFFDYRckdhyrvynlcsERDYDPQKFYGRVAKY---PFDDHNAPP
||..  |                       .. ..|..           . ..... ...            |. |||..| ... ||   |..|..||.
dlnvrdivmsrdevladelsrLdaAlgKtpllildgng..........neptaadlellk............eelydpelferlgikylripvpDgsapl

FLLMQPFCEDVHQYlseDSRNVAVIHCKAGKGRTGV-MISAYLMHCGLFeKTEEALEFYGHARTMNGKGVTIPSQVRYVHYYGRY
.  .. |.| ....   |  .. ..||||||||||. .. ||||..  .   |||||..  .|..| . ..|... .|. .. ..
ledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnpgfieqleqyefileal
0051082 (Phosphotyrosine protein) phosphatases II 23-178 3e-25 84.0 In-house 6-147 (151) alignment 
Range on Protein: 23-178
Range on HMM: 6-147/151.0
LDLTFITRNIVAMGFPAEgregiyrnhmrDVKRFFdyRCKDHYRVYNLCS--ERDYDPQKFYG---RVAKYPFDDHNAPPFLLMQPFCEDVHQYLSEDSR
......| .. ..|.| .           |. ...  .  ... ..||.|  ||.|.|. .     .|  .|..|. .|.. |..... .....| ... 
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NVAVIHCKAGKGRTGVMISAYLMHCGlfEKTEEALEFYGHARTmngkGVTIPSQVRYVHYY
.. ..||.|||||||... .|||..|     |||||.|   |.    ||..|.| ......
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp....gvvqpnqqflfqlf
subfamily_CDC14_pd Subfamily CDC14 26-149 5.9e-09 30.2 In-house 173-295 (328) alignment 
Range on Protein: 26-149
Range on HMM: 173-295/328.0
TFITRN-IVAMGFPAEGREGIYRNHMRDVKRFFDYRCKDH-YRVYNLcSERDYDPQKFYGRVA---KYPFDDHNAPPFLLMQPFCEdvhqyLSEDSRNVA
..|. . ..|.  | . ..   . ...  .....|  | .   |  |  .. || .||           | |   |.  ... | |     ..|...  .
nwivPdkflalagPhnkskledgyplhaPeklleyfrknnvttvvrL.nkklYdakkftdaGfdhkDlffiDGstPsdaivkkfle.....iaekaeGai

VIHCKAGKGRTGVMISAYLMHCGLFEKTE
..||||| |||| .|..|||.   |  .|
avhCkaGLGrtGtLiacylmkhyrftaae
0038934 (Phosphotyrosine protein) phosphatases II 27-185 3.3e-37 123.4 In-house 15-173 (194) alignment 
Range on Protein: 27-185
Range on HMM: 15-173/194.0
FITRNIVAMGFPAEG-----REGIYRNHMRDVKRFFDYRCKDHYRVYNLC-SERDYDPQKFYG---RVAKYPFDDH-NAPPFLLMQPFCEDVHQYLSEDS
.|| ...|...|..|      |..||....|. |..... .... |..|. .|| |||..|..   .. |.|| |. ..|.. ... |.. |...|.||.
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

RNVAVIHCKAGKGRTGVMISAYLMHCGLFeKTEEALEFYGHARtmngkgvtiPSQVRYVHYYGRYVREQ
 .| ..|||||.||||... |||...  . . |||....  .|         |.......|.  ...  
ggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekR.........pgaipnqdyleallkry
0049260 (Phosphotyrosine protein) phosphatases II 33-182 5.4e-32 106.0 In-house 5-149 (152) alignment 
Range on Protein: 33-182
Range on HMM: 5-149/152.0
VAMGFPAEGREGIYRNHMRDVKRFFDYRCKDHYRVYNLCSERDYDPQKFYGRVAKYPFDDHNAPPFLLMQPFCEDVHQYLSEDSRNVAVIHCKAGKGRTG
.||.|.. . .|...|.. |..|..     ... ... ..|....  ..| ..  .|..||..|..  . .|. .... | .|. .. ..||.||.||||
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtg

VMISAYLMHcglfeKTEEALEFYGHARTMNGKGVTIPSQVRYVHYYGRYV
... ||||.     .  ...|.. . |... ..|. |.| |..... ...
tlvaaylml.....lgvsleeavalvrekRpgavpnpgqlrflyefekll
0048179 (Phosphotyrosine protein) phosphatases II 37-180 3.6e-26 87.0 In-house 3-142 (144) alignment 
Range on Protein: 37-180
Range on HMM: 3-142/144.0
FPAEGREGIYRNHMRDVKRFFDYRCKDHYRVYNLCSERDYDPQKFYG-RVAKYPFDDHNAPPF-LLMQPFCEDVHQYLSEDsrNVAVIHCKAGKGRTGVM
.|.|  .|.|.... .....  ..  ... |.||..|....  ...| .. ..|..||..|..  |.. |.| ....|.|.  .. ..||.||.||||..
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtl

ISAYLMHcglfEKTEEALEFYGHARTMNGKGVTIPSQVRYVHYYGR
. ||||.    ..   . | . . |...  .|. |.|.|....|..
vaaylmk....klglsleealalvrsrrpgavpnpgqlrfLleyek
0048076 (Phosphotyrosine protein) phosphatases II 37-180 1.6e-25 84.8 In-house 3-140 (145) alignment 
Range on Protein: 37-180
Range on HMM: 3-140/145.0
FPAEGREGIYRNHMRDVKRFFDYRCKDHYRVYNLCSERDYDPQKFYgRVAKYPFDDHNAPPF-LLMQPFCEDVHQYLSEDsrNVAVIHCKAGKGRTGVMI
.|.|  .|.|.. . .....  ..  ....|.||.||...  .. . ..  .|..||..|..  |.. |.| ....|.|.  .. ..||.||.||||...
wpseilpglylgslptaldlellkdlgittvlnltselellerlgi.qylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlv

SAYLMHCglfeKTEEALEFYGHARTMNGKGVTIPSQVRYVHYYGR
 ||||..    .   . | . . |..  ..|. |.|.|..... .
aaylmll....lgvsleealelvrsqrpgavpnpgqlrflyefel
0051429 (Phosphotyrosine protein) phosphatases II 51-178 2.8e-11 39.1 In-house 36-220 (272) alignment 
Range on Protein: 51-178
Range on HMM: 36-220/272.0
RDVKRFFDYRCKdhyRVYNLCSERDYDPQK-----FYGRVAKYPFDDHNAPPFLLMQ-------------------------------------------
.|..|. ....|    . .|.||  .. .|        |.  .|. |. ||. |...                                           
adfwrlkelgik...tivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpd

-----PFCEDVHQYLSEdsRNVAVIHCKAGKGRTGVMISAYLMHCGLFEKT-EE--------ALEFYGHARTMNGKGVTIPSQVRYVHYY
       . .. ..| .   .  ..||.|||.|||... ..|.  |. . |  .        ..|.. . | .  . |  . |..... .
hgvpqeallellellld..ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyea
0051299 (Phosphotyrosine protein) phosphatases II 56-177 1.7e-21 72.4 In-house 153-280 (288) alignment 
Range on Protein: 56-177
Range on HMM: 153-280/288.0
FFDYRCKDHYRVYNLCSERD----YDPQKFYGRVAKYP-FDDHNAPP-FLLMQPFCEDVHQYLSeDSRNVAVIHCKAGKGRTGVMISAYLMHCGL-FEKT
. ..  .|.| |..|. ..     .| .... ..  |. . ||..|. . |.  |...|...|. .. .. |.||.||.||||..| ..|... | .|..
llseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekegg

EEALEFYGHARTMNGKGVTIPSQVRYVHY
 ..||.. . |..    |. |.| |.|..
vdvleavkrlreqRpgmvqtpeqyrfvye
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 56-139 4.5e-06 20.9 In-house 138-223 (274) alignment 
Range on Protein: 56-139
Range on HMM: 138-223/274.0
FFDYRCKDHYRVYNLCSERDYDPQKFYGRV-AKYPfdDHNAPP-FLLMQPFCEDVHQYLSEDSRN--VAVIHCKAGKGRTGVMISAYL
. .   ...|.| .|  .   .... .    ...|  ||..|     .  ....|..  .|.. .   .|.|| || ||||. |.. .
vekiverndysvrklvlkylerersvkhywytdWP..dhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi
0047943 (Phosphotyrosine protein) phosphatases II 57-178 2.7e-21 71.7 In-house 142-267 (273) alignment 
Range on Protein: 57-178
Range on HMM: 142-267/273.0
FDYRCKDHYRVYNLCSERDYDPQKFYGRVAKYP-FDDHNAP-PFLLMQPFCEDVHQYLSED-SRNVAVIHCKAGKGRTGVMISAYLMHCGL-FEKTEEAL
 ..  ||.| |..|. ..  ...... ..  |. . ||..|  .  .  |.|.|...|... | .. |.||.||.||||..| ..|... |  |..  .|
lseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvl

EFYGHARTMNGKGVTIPSQVRYVHYY
| . . |..   .|. |.| |.....
eavkllrsqRpgmvqtpeqyrflyea
0050432 (Phosphotyrosine protein) phosphatases II 58-178 2.5e-16 55.3 In-house 174-294 (308) alignment 
Range on Protein: 58-178
Range on HMM: 174-294/308.0
DYRCKDHYRVYNLCSERDYDPQKFYGRVAKYPF-DDHNAPP-FLLMQPFCEDVHQYLsedSRNVAVIHCKAGKGRTGVMISAYLMHCGL-FEKTEEALEF
..  .|.| |..|. .   |.. .. ..  |.   ||..|| .  .  |.| |...|   . .. |.||.|| ||||..| ..|... |  |..  ..| 
seevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfea

YGHARTMNGKGVTIPSQVRYVHYY
. . |..    |. |.| ......
vkklReqRpgmvqtpeqylflyra
subfamily_PRL_pd Subfamily PRL 71-178 2.6e-10 34.5 In-house 41-145 (151) alignment 
Range on Protein: 71-178
Range on HMM: 41-145/151.0
CSERDYDPQKFY---GRVAKYPFDDHNAPPFLLMQPFCEDVHQYLSEDSRNVAVIHCKAGKGRTGVMISAYLMHCGLfeKTEEALEFYGHARtmngKGVT
. |  || .|.     .|  ..||| ..||  ... . | ...  .|.. ..  .|| || ||. |...  |. .|.  |.|.|.||  . |    .|  
vceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm..kyedavefirekr....rgai

IPSQVRYVHYY
   |..... |
nskqlkfleky
subfamily_DSP11_pd Subfamily DSP11 73-160 7.9e-09 29.6 In-house 67-158 (178) alignment 
Range on Protein: 73-160
Range on HMM: 67-158/178.0
ERDYDPQKFYGRVA---KYPFDDHNAPPFLLMQPFCEDVHQYL--SEDSRNVAVIHCKAGKGRTGVMISAYLMHCGLFeKTEEALEFYGHART
.| |.....  .     |     |. |   |.. |.| |...|  ..|. ..  .||  |  ||| .|  ||...  . ..|.|.| . .|| 
dryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegy.epedaieafeearG
subfamily_PTPDC1_pd Subfamily PTPDC1 86-186 2.9e-10 34.9 In-house 86-179 (182) alignment 
Range on Protein: 86-186
Range on HMM: 86-179/182.0
AKYPFDDHNAPPFLLMQPFCEDVHQYLSEDsrNVAvIHCKAGKGRTGVMISAYLMHCGLFEkTEEALEFYghaRTMNGKGVTIPSQVRYVHYYGRYVREQ
 .....|.....   .      |.. |.|.  .|| .|| ||.|||||.|..||..   .. .|.|...    |    | .   .||. |. .  .. ..
ynfgwkDygvasleriLdivkvvafalqeg..kva.vhChaGlGrtGvliacylvyakrlt.aekaiklv...rskrpksiqtreqvelvkefalflipl

R
|
r
0048567 (Phosphotyrosine protein) phosphatases II 89-181 5.3e-09 30.6 In-house 44-137 (157) alignment 
Range on Protein: 89-181
Range on HMM: 44-137/157.0
PFDDHNAPPFLLMQPFCEDVHQYLS--EDSRNVAVIHCKAGK---GRTGVMISAYLMHCGLFekteEALEFYGHARTMNGKGVTIPSQVRYVHYYGRY
.| |.  ..  .   |.  ....|.  |  ... ..|||||    |||...|..||. .  |     . |.... | .. . |  . .  ....|. .
fffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgf....tpeeaiaplrivrpgsvpfrdasyllslynlt
PTPc_motif_SM00404 90-159 9.4e-07 23.8 In-house 54-121 (140) alignment 
Range on Protein: 90-159
Range on HMM: 54-121/140.0
FDD-HNAPPFLLMQPFCEDVHQYlsEDSRNVAVIHCKAGKGRTGVMISAYLMHCGLFeKTEEALEFYGHAR
 || .... .  ..   . ...   |...   ..||.||  |.. .| ||||.   . ...||.||. . |
lddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmryrql.slaeayefvkerR
PTPc_DSPc_SM00012 91-177 1.7e-10 36.4 In-house 11-101 (105) alignment 
Range on Protein: 91-177
Range on HMM: 11-101/105.0
DDHNAPP-FLLMQPFCEDVHQYLSEDS-RNVAVIHCKAGKGRTGVMISAYLMHCGLFEKT--EEALEFYGHARTMNGKGVTIPSQVRYVHY
 ||..|     .  ....|..  .. . ..  |.||.|| ||||... ...... | ..|   . ...  . |..  . |.   |. ... 
pdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr
DSPc Dual specificity phosphatase, catalytic domain 91-162 1e-07 26.9 Pfam-A 48-117 (133) alignment 
Range on Protein: 91-162
Range on HMM: 48-117/133.0
DD-HNAPPFLLMQPFCEDVHQYlSEDSRNVaVIHCKAGKGRTGVMISAYLMHCGLFeKTEEALEFYGHARTMN
.| ...     ..   | ...   .. ..| ..||.||  |.. .| ||||    . ...||.||    | . 
edetetkiskeleeavefieka.eqkgkkv.lVHCqaGisRSatliiaYlmktknl.slneAyefvkerrski
DSPc Dual specificity phosphatase, catalytic domain 91-162 1e-07 26.9 In-house 48-117 (133) alignment 
Range on Protein: 91-162
Range on HMM: 48-117/133.0
DD-HNAPPFLLMQPFCEDVHQYlSEDSRNVaVIHCKAGKGRTGVMISAYLMHCGLFeKTEEALEFYGHARTMN
.| ...     ..   | ...   .. ..| ..||.||  |.. .| ||||    . ...||.||    | . 
edetetkiskeleeavefieka.eqkgkkv.lVHCqaGisRSatliiaYlmktknl.slneAyefvkerrski
Y_phosphatase Protein-tyrosine phosphatase 91-175 2.6e-06 22.4 Pfam-A 144-229 (235) alignment 
Range on Protein: 91-175
Range on HMM: 144-229/235.0
DDHNAPP-FLLMQPFCEDVHQYLsEDSRNVAVIHCKAGKGRTGVMISAYLMHCGLFE-KTEEALEFYGHARTMNGKGVTIPSQVRYV
 ||..|     .  ....|...  |....  |.||.|| ||||..... .. . | . .. . |..  . |.   . |.  .|  ..
pdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl
Y_phosphatase Protein-tyrosine phosphatase 91-175 2.6e-06 22.4 In-house 144-229 (235) alignment 
Range on Protein: 91-175
Range on HMM: 144-229/235.0
DDHNAPP-FLLMQPFCEDVHQYLsEDSRNVAVIHCKAGKGRTGVMISAYLMHCGLFE-KTEEALEFYGHARTMNGKGVTIPSQVRYV
 ||..|     .  ....|...  |....  |.||.|| ||||..... .. . | . .. . |..  . |.   . |.  .|  ..
pdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl
subfamily_RNGTT_pd Subfamily RNGTT 102-160 1.7e-07 25.1 In-house 98-155 (189) alignment 
Range on Protein: 102-160
Range on HMM: 98-155/189.0
QPFCEDVHQYLSEDSRNVAVIHCKAGKGRTGVMISAYLMHCGLFEkTEEALEFYGHART
. | . |... .. ...|  .||. |  ||| .| .||..   ..  |.|.. . .|| 
kefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedws.veaavalFakaRp
subfamily_PTPMT1_pd Subfamily PTPMT1 106-159 4.7e-07 24.4 In-house 98-148 (171) alignment 
Range on Protein: 106-159
Range on HMM: 98-148/171.0
EDVHQYLSEDSRnVaVIHCKAGKGRTGVMISAYLMHCGLFEkTEEALEFYGHAR
| .... |. .| |  .|||||.||.. ....|||.   .. .||||..  . |
efiekvaskgkr.v.YvHCkaGrgRsatlvacylmkkekls.peeAlkalkkkR
Y_phosphatase3 Tyrosine phosphatase family 107-147 1e-06 23.9 Pfam-A 115-154 (164) alignment 
Range on Protein: 107-147
Range on HMM: 115-154/164.0
DVHQYLSEDSrNVAVIHCKAGKGRTGVMISAYLMHCGLFEK
.| . | |.. . ...||.||| ||||..   |  .|  |.
kvlealaeee.gpvlfHCtaGKDRTGvvaalllsllgvdee
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 190-317 9.9e-32 100.9 Pfam-A 3-133 (134) alignment 
Range on Protein: 190-317
Range on HMM: 3-133/134.0
PIPLIMKRIILHGIPDF-KDGTCVPQFTLRHGPQHVLTFKSGWYEGISREQGTATLELKPHTPVCGDVKLEFIHRK-GSSGKEKMFHLWFNTFFIV--NN
| .| .|.|||.|||.| ..|.| |...   | . | . .. . .   |.. |......   ||.|||..||.|..  .. |||.|..||||.||   .|
pkrlelksiilegiPnfktrggckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsklpkkekifrvwFNTsFieknqn

RFYAAQSEVDKANKDKkNKIYPEGFAIEILFD
. .  ..|.|||.||| .| ....|..|..|.
vltlpkneLDkalkdk.dkkfsknfkvelvfe