Gene Tensin in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily Tensin
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP030_AA protein Get Run
MbreP030_AA_129-300 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
C1_1 Phorbol esters/diacylglycerol binding domain (C1 domain) 71-117 2e-06 17.5 Pfam-A 1-51 (53) alignment 
Range on Protein: 71-117
Range on HMM: 1-51/53.0
HVFVEGQ-GFGKPCRICTDRV---WRRAAMCTNCRYICHERCIGQARKHLD
| .|...    . |  | . .   . ..  |..| ...|..|. .. |  .
HhwvhrnfkqptfCkhCgkflwgkgkqglkCswCqllvHkkCfekvpkecg
subfamily_VSP_pd Subfamily VSP 124-298 6.3e-46 151.0 In-house 8-198 (212) alignment 
Range on Protein: 124-298
Range on HMM: 8-198/212.0
KTSTLVRQIRKVVTGNKVRYVTEVVDLDLTYITPRIIAMSLPATGLQAAYRNNLKDVAAFLNSKHGSNYMIFNV-SDKKYDIEEFHNQVLDFGWPDHMAP
. . | . .|..|. || ||  .  ||||||.| ||||||.|..| |. ||| ...|| ||. ||  .| ..|. |...|| . |.|.|      ||  |
qkrklekaarrlvsenkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvp

SLERLASICNSIDSWIEADPNNVIAVHCKGGKGRTALS-----TNSPS----------FGADIISFTSDKKSSGITNPSQRRYVLYFEAVL
.||.| .... .  |.|.|..||.|.|||||||||         .|            ||      |  .|  |.  |||.||| |.| | 
kleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvk
0039614 (Phosphotyrosine protein) phosphatases II 130-299 4.6e-25 84.1 In-house 49-289 (297) alignment 
Range on Protein: 130-299
Range on HMM: 49-289/297.0
RQIRKVVTGNKVRYV--------------TEVVDLDLTYI-----------TPRIIAMSLPATG-----LQAAYRNNLKDVA------------------
.  .... ..| ||.               . ||||..||           |...||.. | ..     ..  .... . .                   
siallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpe

----------AFLNSKHGSNYMIFNVSDKKYDIEEFHNQVLDFGWPDHMAP-SLERLASICNSIDSWIEAD-PNNVIAVHCKGGKGRTAL----------
           .|. .| ..|.... . .... . ...... .||||| .| ||| | .... ........ ......|||..|.|||.           
eggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleq

--STNSPSfGADIISFTSDKKSSGITNPSQRRYVLYFEAVLA
  ..  ..   .....   ... ....||| |.. .... | 
lekeggvd.vleavkelreqRpgavqtpsqyrflydallell
subfamily_PTEN_pd Subfamily PTEN 132-301 2.9e-51 169.1 In-house 2-182 (184) alignment 
Range on Protein: 132-301
Range on HMM: 2-182/184.0
IRKVVTGNKVRYVTEVVDLDLTYITPRIIAMSLPATGLQAAYRNNLKDVAAFLNSKHGSNYMIFNV-SDKKYDIEEFHNQVLDFGWPDHMAPSLERLASI
.||.|  .| |. .. .||||.|||..||||. ||..|.|.|||.|.||  ||..||  .|.|.|. |..||| ..|...|  ..  ||..|.|| |..|
lrkivskkkkrfkedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleei

CNSIDSWIEADPNNVIAVHCKGGKGRTALST-------NSPSFGADIISF---TSDKKSSGITNPSQRRYVLYFEAVLAGQ
...|..|.|.|..||..|||| ||||| . .       .  .   .....   .  |...|.| ||||||| |.|..|  .
vediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyeklleee
PTEN_1 133-300 1.7e-37 124.2 In-house 3-194 (196) alignment 
Range on Protein: 133-300
Range on HMM: 3-194/196.0
RKVVTGNKVRYVTEVVDLDLTYITPRIIAMS-LPATG-----LQAAYRNNLKDVAAFLNSKHGSN-YMIFNVSDKK------YDIEE-FHNQVL--DFGW
|.  . .| ..  .  .|||||||.|||||.  |...      .  ||..||||||.|....... ....|.|...      || || |...|   .|..
rlskrsskknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpi

PDHMAPSLERLASICNSIDSWIEADP-NNVIAVHCKGGKGRTA-------LSTNSpSFGADIISFTSDKKSSGITN-PSQRRYVLYFEAVLAG
.|| ||||..|  ||.|...|. .|| .||..||||.|.||..       ....  .   . ...  .| . |  | |||.|.. ||.  ||.
eDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapnspsqerlleyfaellae
0037934 (Phosphotyrosine protein) phosphatases II 134-297 1.5e-25 85.6 In-house 7-240 (243) alignment 
Range on Protein: 134-297
Range on HMM: 7-240/243.0
KVVTGNKVRYV--------------TEVVDLDLTYITPRIIAMSLPATG---------LQAAYRNNLKDVA----------------------------A
...  .| ||               .  ....|.|.|||.||...| ..         ..  .... . .                              
lpenlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvt

FLNSKHGSNYMIFNVSDKK---YDIEEFHNQVLDFGWPDHMAPS-LERLASICNSIDSWIEA-------DPNNVIAVHCKGGKGRTA-------LSTN-S
.|...|...|...... .    .| . .. ... ..|||| .|.  | | .... . ..||.       |......|||..|.|||.       . .. .
llseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllg

pSFGADIISFTSDKKSS-GITNPSQRRYVLYFEAV
     ... .  ....  ....|||.|.. .... 
.vdleeavkllreqRpgkavqtpsqyrflyealle
0042113 (Phosphotyrosine protein) phosphatases II 136-296 1.6e-21 72.3 In-house 8-240 (245) alignment 
Range on Protein: 136-296
Range on HMM: 8-240/245.0
VTGNKVRY-------------VTEVVDLDLTYI----------TPRIIAMSLPATGLQA-----AYRNNLKDVA--------------------------
. ..| ||               .  |||..||          ||..||.. |...  .      ...... .                           
enkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltyg

----AFLNSKHGSNYMIFNVSDK--KYDIEEFHNQVLDFGWPDHMAPS-LERLASICNSIDSWIEADPNNVIAVHCKGGKGRTAL------------STN
     .|. .| ..|...... .  ..| . ...... ..|||| .|. || | .... .......|.|....|||..|.|||..            .. 
dftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekel

SPSfGADIISFTSDKKSSGITNPSQRRYVLYFEA
  |   ... .  ....  ...||| |.. ....
gvs.leeavkelrsqRpgavqtpsqyrflyeall
0040438 (Phosphotyrosine protein) phosphatases II 136-299 3.5e-19 64.6 In-house 42-276 (317) alignment 
Range on Protein: 136-299
Range on HMM: 42-276/317.0
VTGNKVRY-------------VTEVVDLDLTYI----------TPRIIAMSLPATG-----LQAAYRNNLKDVAAFLNSK--------------------
. ..| ||               .  |||..||          ....||.. |  .     ..  ...... .  . ...                    
enkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltyg

------------HGSNYMIFNVSDKKYDIEEFHNQVLDFGWPDHMAP-SLERLASICNSIDSWIEaDPNNVIAVHCKGGKGRTAL------------STN
            .| ..  . |.|.. . . . ..    ||||| .| |.. | .... .....| ||.....|||..|.|||.              ..
dftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg

SPSfGADIISFTSDKKSSGITNPSQRRYVLYFEAVLA
 ..   ... .   ... ....|.| |.. .... . 
gvd.veeavkelreqRpgavqtpeqyrflydalleyl
0045450 (Phosphotyrosine protein) phosphatases II 136-297 2.4e-16 55.8 In-house 54-302 (307) alignment 
Range on Protein: 136-297
Range on HMM: 54-302/307.0
VTGNKVRYVT-------------------------------------EVVDLDLTYI----------------------------------TPRIIAMSL
. ..| ||.                                      .. ||....|                                  . ...|.  
enkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqyw

PATGLQAAYRNnlkDVAAFLNSKHGSNYMIFNVSDKKYDIEEFHNQVLDF---GWPDHMAP-SLERLASICNSIDSWIEAD-PNNVIAVHCKGGKGRTAL
| .| .  |.|   ..  .|. .| ..| ....  . .| .... .|  |   ||||| .| |.| | .... .....|.. ......|||..|.|||. 
Pdegeeltygn...ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGt

--------------------StnspsfGADIISFTSDKKSSGITNPSQRRYVLYFEAV
                    .        .....  .... ...||.| |.. .... 
fiaaylmlrqlekegtlldvd......lleavkllreqRpgavqnpeqyrflyealle
0044763 (Phosphotyrosine protein) phosphatases II 138-299 7.8e-18 60.2 In-house 9-171 (178) alignment 
Range on Protein: 138-299
Range on HMM: 9-171/178.0
GNKVRYVTEVVDLDLTYITPRIIAMSLPATG-LQAAYRNNLKDVAAFLNSKHgsnymIFNVSDKKYDIEEFHNQVLDFGWPDHMAPS-LERLASICNSID
 ......  .  .....|.|.....|||.   |.  ...... .  . . ..      . ... .|. ||.. |.| ...||| .|. || .  ... |.
lsnleglersdyinaseilpglylgslppaddlellkelgithivnlteele.....lgflkcdpywpeeagiqylhipipDhgvpdllehflefvefie

SWIEaDPNNVIAVHCKGGKGRTALST------NSPSFGADIISFTSDKKSsGITNPSQRRYVLYFEAVLA
.... .......|||. |.||...               ..|..   ... ...||.|.|....||  | 
eald.ekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll
subfamily_Tensin_pd Subfamily Tensin 140-315 1.5e-73 239.4 In-house 1-188 (189) alignment 
Range on Protein: 140-315
Range on HMM: 1-188/189.0
KVRYVTEVVDLDLTYITPRIIAMSLPATGLQAAYRNNLKDVAAFLNSKHGSNYMIFNVSDKKYDIEEFHNQVLDFGWPDHMAPSLERLASICNSIDSWIE
|||||.| ||||||||| ||||.|.||.||...||.||||||..|.|||...|..||.|.|.|||......||||||||..|||||.|.|||.|.|||..
kvryveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWlk

ADPNNVIAVHCKGGKGRTAL--------STNSPSFGADIISFT----SDKKSSGITNPSQRRYVLYFEAVLAGQLKVYRKHLVLEHVY
|||.||..|||||||||...        |..| |  |....|.    .|.|.||.|.||||||| ||...|.|..|.  . | | .| 
adpqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkiklnssplflhyvi
0043336 (Phosphotyrosine protein) phosphatases II 141-296 1.8e-21 72.3 In-house 49-274 (278) alignment 
Range on Protein: 141-296
Range on HMM: 49-274/278.0
VRY-------------VTEVVDLDLTYI----------TPRIIAMSLPATGLQAAYRNNLKD----------------------------------VAAF
 ||               .  |||..||          ....||.. | ..  . ... ...                                  .  .
nrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtl

LNSKHGSNYMIFNVSDK--KYDIEEFHNQVLDFGWPDHMAP-SLERLASICNSIDSWIEaDPNNVIAVHCKGGKGRTAL------------STNSPSfGA
|. .| ..|....   .  ... . .....  .||||| .| ||. | .... .....| |.|....|||..|.|||..            ..  ..   
lkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvd.le

DIISFTSDKKSSGITNPSQRRYVLYFEA
.....   .. . ...||| |.. ....
eavkelreqRpgavqtpsqyrflyeall
0046846 (Phosphotyrosine protein) phosphatases II 142-298 2.8e-24 81.2 In-house 2-172 (176) alignment 
Range on Protein: 142-298
Range on HMM: 2-172/176.0
RYVTEVVDLDLTYITPRIIAMSLPATGLQAAYRNNLKDVAAFLNSkhgSNYMIFNVSDKK-----------YDIEEFHNQVLDFGWPDHMAPSLERLASI
|..  . ||||.||....|..|.|...    .|.  .... ...      ....|. . .            ..|... |.| ..|||| .|.|| | ..
rlrllgldldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllel

CNSIDSWIEADpnNVIAVHCKGGKGRTALS-------TNS---PsfgADIISFTSDKKS-SGITNPSQRRYVLYFEAVL
.. |.......  ....|||..|.|||..        ..    .    .....  ....   ...|.|.|.. .||  |
lefirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsv...eealalvreqRplgavqtpeQyrflyefelll
0043147 (Phosphotyrosine protein) phosphatases II 146-298 2.1e-23 78.3 In-house 9-160 (172) alignment 
Range on Protein: 146-298
Range on HMM: 9-160/172.0
EVVDLDLTYITPRIIAMSLPatglqaaYRNNLKDVAAFLNSKHGSNymIFNVSDK---KYDIEEFHNQVLDFGWPDHMAPSLERLASICNSIDSWIEADP
 . .|||.||..|.||.  |       .||.| |. ..| ... .   |.|. .    ... |..  |.| ..|||| .|.|| | .... ||...  .|
nasyldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalsp

NNVIAVHCKGGKGRTALS------TnSPSFGADIISFTSDKKSSGITNPSQRRYVLYFEAVL
.....|||..|.|||..               .....  .|.. ...||||.|...|||  |
ggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
0046845 (Phosphotyrosine protein) phosphatases II 146-295 3.8e-18 61.3 In-house 66-270 (284) alignment 
Range on Protein: 146-295
Range on HMM: 66-270/284.0
EVVDLDLTYITPRIIAMSLPATG-----------------------------LQAAYRNNLKDVAAF-------LNSKHGSNYMIFNVSDKKY---DIEE
.. |||||||....||.. |  .                               | |... ..|  .       |. .. ..|...... ...   . . 
dgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesr

FHNQVLDFGWPDHMAP-SLERLASICNSIDSWIEA-DPNNVIAVHCKGGKGRTA-----------LSTNS---PSFGADIISFTSDKKSSGITNPSQRRY
....   ..|||| .| |.| | .... .....|. .....|.|||..|.|||.           | ...        .....  ...   .....| |.
tvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrf

VLYFE
| .. 
vyeal
0036282 (Phosphotyrosine protein) phosphatases II 148-300 9.6e-32 105.4 In-house 8-171 (174) alignment 
Range on Protein: 148-300
Range on HMM: 8-171/174.0
VDLDLTYITPRIIAMSLPATGLQAAYRNNLKDVAAFLNSKHGSNYMIFNVS-DKKYDIEEFHNQVLDFGWPDHMAPSLERLASICNSIDSWIEADPNNVI
 .|||.|||||.||.. |.. ..  .......|  .|..|.  .|...|   ....| |... |.|...|||| .|.|. | .... ...... ||....
spldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpv

AVHCKGGKGRTAL--------STNSpSFGADIISFTSDKK---SSGITNPSQRRYVLYFEAVLAG
.|||..|.|||..             .   |....   ..   . ....|||.|.. ||| .| |
lVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyyfekllsg
0041856 (Phosphotyrosine protein) phosphatases II 148-297 1.3e-25 85.5 In-house 15-169 (182) alignment 
Range on Protein: 148-297
Range on HMM: 15-169/182.0
VDLDLTYITPRIIAMSLPATGLQAAYRNNLKDVAAFLNSKHGSNY-MIFNVSDKKYDIEEFHN---QVLDFGWPDHMAPSlerLASICNSIDSWIEadPN
 ..||.||.......|||||   |.... |..||.||.  .. .. .| |...  |. |....   |.|...|||| .|.   | .... |. ..|  ..
hsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd...ldelldfieevle..eg

NVIAVHCKGGKGRTA------LSTNSPSFGADIISFTSDKKSSGITNPSQRRYVLYFEAV
....|||..|.|||.      |         .....   ... ....|.| ... ...  
gpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlalle
subfamily_Auxilin_pd Subfamily Auxilin 149-298 4.8e-41 133.2 In-house 8-164 (166) alignment 
Range on Protein: 149-298
Range on HMM: 8-164/166.0
DLDLTYITPRIIAMSLPATGLQAAYRNNLKDVAAFLNSKHGSNYMIFNVSDKKYDIEEFHNQVLDFGWPDHMAPSLERLASICNSIDSWIEADPNNVIAV
|||..||| ||| || || |.. .|.||..||..||.|.| ..|...|.|...|. ......|.. ||| . ||.|| | ..|  ..||...||.||. |
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvvv

HCKGGKGRTALSTNSP--------SFGADIISFTSDKKSSGITnPSQRRYVLYFEAVL
||| |.  .|.   .         .  . .  |.  ... |.. ||..||. |. ..|
hckDGraasavlvsallvfcrllsepesavrlfsvkrlpigls.psekryleyladll
0045098 (Phosphotyrosine protein) phosphatases II 149-299 3.1e-18 61.6 In-house 6-272 (278) alignment 
Range on Protein: 149-299
Range on HMM: 6-272/278.0
DLDLTYITPRIIAMSLPATGLQAAYRNNLK----------------------------------------------------------------------
.|||.... ...... | . . | |..||.                                                                      
sldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrek

---------------------DVAAFlNSKHGSNYMIFNVSDKKYDIEEFHNQVLDF-GWPDHMAPSLE---RLASICNSIDSWIE------------AD
                     ..  . .  .   ... |.. ...|.|... ..|.. .|||| .|||.    . .... |.....             |
caqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllld

PNNVIAVHCKGGKGRTA-----------LstNSPSFGADIISFTSDKKSS-GITNPSQRRYVLYFEAVLA
......|||. |.|||.           |  ..     .....   ..    ..|..| |.. .|.. | 
sggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
0040439 (Phosphotyrosine protein) phosphatases II 150-297 1.1e-18 63.2 In-house 47-244 (249) alignment 
Range on Protein: 150-297
Range on HMM: 47-244/249.0
LDLTYITPRIIAMSLPATGLQAAYRNNLKD-----------------------------------VAAFLNSKHGSNYMIFNVSDKK-YDIEEFHNQVLD
.|..||..|.||.. | ..  ..... |..                                   .  .|. .. ..|.....  .. || |... ... 
idgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiq

F-GWPDHMAP-SLERLASICNSIDSWIEAD-PNNVIAVHCKGGKGRTAL------------STNSPSfGADIISFTSDKKSSGITNPSQRRYVLYFEAV
. .|||| .| |.| | .... .....|.. ......|||..|.|||..             ..  .   .....  .... ...||.| |....... 
ytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvd.leeavkllrsqRpgavqnpeqyrflyealle
0051082 (Phosphotyrosine protein) phosphatases II 150-259 1.6e-15 52.5 In-house 6-108 (151) alignment 
Range on Protein: 150-259
Range on HMM: 6-108/151.0
LDLTYITPRIIAMSLPATglqaayrnnlkDVAAFLnsKHGSNYMIFNVSDKK---YDIEEFHN---QVLDFGWPDHMAPSLERLASICNSIDSWIEADPN
....|.|....... |             |. ..|  |.   ..|.|. ...   |. | ...   .||.. ..|. .|.|. .  ..... .......|
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NVIAVHCKGGKGRTAL
....|||..|||||..
gpvlvHCsaGkgRTGt
0038934 (Phosphotyrosine protein) phosphatases II 154-289 3.4e-26 87.5 In-house 15-167 (194) alignment 
Range on Protein: 154-289
Range on HMM: 15-167/194.0
YITPRIIAMSLPATG-----LQAAYRNNLKDVAAFLNSKHGSNYMIFNVS--DKKYDIEEFHN---QVLDFGWPDH-MAPSLERLASICNSIDSWIEADP
.||.|.||...|..|     ..  ||....|.  .|....  .... ...  .. || |||..   ..|.. .||.  .|||| | .... .| ....||
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

NNVIAVHCKGGKGRTAL------STNSPSFGADIISFTSDKKSSGITNPSQRR
..|.|||||.|.|||..               . | . ..|. ..| |... .
ggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyle
0049772 (Phosphotyrosine protein) phosphatases II 154-258 1.1e-14 50.4 In-house 118-227 (314) alignment 
Range on Protein: 154-258
Range on HMM: 118-227/314.0
YITPRIIAM---------------------SLPATGLQaayrnNLKDVAAFLNSKhgsnymifnvsDK---KYDIEEFHNQVLDFGWPDHMAPSLERLAS
 . .|.| |                      |...|..     |. ..| . . |           .    . . |. . ..|.. .||. ||.|| . .
dlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk...........eelydpelferlgikylripvpDgsaplledfde

ICNSIDSWieaDPNNVIAVHCKGGKGRTA
... |...   |......||||.|||||.
flefieea...dkggpvlvHCkaGkgRtg
0049260 (Phosphotyrosine protein) phosphatases II 160-297 1.7e-19 65.4 In-house 5-148 (152) alignment 
Range on Protein: 160-297
Range on HMM: 5-148/152.0
IAMSLPATGLQAAYRNNLKDVAAFLNSKHGSNYMIFN-VSDKKYDIEEFHNQVLDFGWPDHMAPSLERLASICNSIDSWIEADPNNVIAVHCKGGKGRTA
.||. .... |. ..|.|.|.  .| . . . .   .  ...... .|.. |.| . |||| .|.|. |  ... .. ..  |......|||..|.|||.
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtg

LS------TnSPSFGADIISFTSDKKSSGITNPSQRRYVLYFEAV
.               .....   |.. ...||.|.|....|| .
tlvaaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekl
0048179 (Phosphotyrosine protein) phosphatases II 165-297 1.1e-17 59.5 In-house 4-143 (144) alignment 
Range on Protein: 165-297
Range on HMM: 4-143/144.0
PATGLQAAYRNNLKDVAAFLNSKHGSNYMIFNVSDKKYDIEEFHN--QVLDFGWPDHMAPSL-ERLASICNSIDSWIEadPNNVIAVHCKGGKGRTA---
|.  |.  |...| ..  . . |.   ....|.... .  .. ..  |.| ..|||| .|.| | | .... |....|  ......|||..|.|||.   
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlv

---LSTNSPSFGADIISFTSDKKSSGITNPSQRRYVLYFEAV
   |         ... .   . . ...||.|.|..|..|  
aaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
0048076 (Phosphotyrosine protein) phosphatases II 166-297 1.9e-18 62.0 In-house 5-141 (145) alignment 
Range on Protein: 166-297
Range on HMM: 5-141/145.0
ATGLQAAYRNNLKDVAAFLNSKHGSNYMIFNVSDKKYDIEEFHNQVLDFGWPDHMAPSL-ERLASICNSIDSWIEADpnNVIAVHCKGGKGRTA------
.  |.  |...| ..  . . |.   ....|... ... |... |.| ..|||| .|.| | | .... |.......  ....|||. |.|||.      
seilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaay

LSTNSPSFGADIISFTSDKKSSGITNPSQRRYVLYFEAV
|         ... .   . . ...||.|.|....||  
lmlllgvsleealelvrsqrpgavpnpgqlrflyefele
0051429 (Phosphotyrosine protein) phosphatases II 178-259 4.5e-07 25.3 In-house 47-166 (272) alignment 
Range on Protein: 178-259
Range on HMM: 47-166/272.0
KDVAAFLNSK-----------HGSNYMIFNVSDKKYDIEEF----------------------------------HNQVLDFGWPDHMAPS--LERLASI
| .  . .             .| .|. ... |  .   ..                                  . . .  .|||| .|.  | .| ..
ktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellel

CNSidswieadpNNVIAVHCKGGKGRTAL
...         .. . |||..||.||..
lld.........ggpvlvHCsaGkdRTGt
0051299 (Phosphotyrosine protein) phosphatases II 184-293 5.4e-12 41.2 In-house 154-280 (288) alignment 
Range on Protein: 184-293
Range on HMM: 154-280/288.0
LNSKHGSNYMIFNVSDK------KYDIEEFHNQVLDFGWPDHMAPS-LERLASICNSIDSWIEaDPNNVIAVHCKGGKGRTALS-----------TNSPS
|. .. ..|.....  .      . . . . ..   ..|||| .|. .| | .... ...... .......|||. |.|||.             ..   
lseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggv

FGADIISFTSDKKSSGITNPSQRRYVLY
   ... .   ..   ...|.| |.| .
dvleavkrlreqRpgmvqtpeqyrfvye
0047943 (Phosphotyrosine protein) phosphatases II 185-294 4.2e-14 48.1 In-house 143-267 (273) alignment 
Range on Protein: 185-294
Range on HMM: 143-267/273.0
NSKHGSNYMIFNVSDK--KYDIEEFHNQVLDFGWPDHMAP-SLERLASICNSIDSWIEAD-PNNVIAVHCKGGKGRTAL------------STNSPSfGA
. .. ..|.....  .  ... . . .... .||||| .| ||| | .... .....||.  |....|||..|.|||.              .. ..   
seetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd.vl

DIISFTSDKKSSGITNPSQRRYVLYF
... .  ...  ....|.|.|.. ..
eavkllrsqRpgmvqtpeqyrflyea
0036941 (Phosphotyrosine protein) phosphatases II 191-298 1.1e-11 40.1 In-house 153-276 (297) alignment 
Range on Protein: 191-298
Range on HMM: 153-276/297.0
NYMIFNVSDKKYDIEEFHNQVLDFGWPDHMAPS-LERLASICNSIDSWIEAD-PNNVIAVHCKGGKGRTAL---------------STNSPSfGADIISF
 .  . |.|.... . . ..   .||||| .|.  . | .... .......  ..... |||..|.||..                 .. ..   ... .
tlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvd.ileavkk

TSDKKSSGITNPSQRRYVLYFEAVL
  ...   .....| |.. .... |
lReqRpgavqtleqyrflyeallel
0050432 (Phosphotyrosine protein) phosphatases II 191-259 1.2e-09 33.4 In-house 182-248 (308) alignment 
Range on Protein: 191-259
Range on HMM: 182-248/308.0
NYMIFNVSDKKYDIEEFHNQVLDFGWPDHMAPS-LERLASICNSIDSWIeadPNNVIAVHCKGGKGRTAL
 .  . ....... . . ..    .|||| .|. .| | .... .....   |...|.|||. | |||. 
tvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGt
subfamily_PTPDC1_pd Subfamily PTPDC1 201-259 3.2e-07 24.9 In-house 72-130 (182) alignment 
Range on Protein: 201-259
Range on HMM: 72-130/182.0
KYDIEEFHNQ---VLDFGWPDHMAPSLERLASICNSIDSWIEADpnnVIAVHCKGGKGRTAL
 || |.. .|   |  |||.|. ..||||.  |   ... .. .    .||||  |.||| .
sYdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGv
PTPc_DSPc_SM00012 209-259 1.3e-07 27.2 In-house 3-55 (105) alignment 
Range on Protein: 209-259
Range on HMM: 3-55/105.0
NQVLDFGWPDHMAPS-LERLASICNSIDSWIEADP-NNVIAVHCKGGKGRTAL
...   ||||| .|.  . . ......... ..   .. . |||. | |||. 
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgt
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 306-459 5.1e-22 69.5 Pfam-A 3-133 (134) alignment 
Range on Protein: 306-459
Range on HMM: 3-133/134.0
RKHLVLEHVYLQGIPAFDGSGGCRPYLSIMEDFRVVYQSPEPIRTFRRD-DKFIQFDLDQGLHLAGDVVIECYHRP--SRGADVlMFRIQFPTCVVADrv
.| | | ...|.|||.|. .|||.|.. ...   .| ....  .  ... .| . ......| . |||..|..|.   .  ..  .||..| |. . .  
pkrlelksiilegiPnfktrggckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsklpkkek.ifrvwFNTsFiek..

sdcmfivvppprrtwvpmrlipmsaWVQVYTFEKHQLDEAYKD--ARFPEETNISCMFR
                           .| |..| .||.| ||   .|... ... .|.
.........................nqnvltlpkneLDkalkdkdkkfsknfkvelvfe
SH2 SH2 domain 689-767 5.5e-10 29.8 Pfam-A 1-77 (77) alignment 
Range on Protein: 689-767
Range on HMM: 1-77/77.0
WYFADFTKEATDRLLLEKGQPGEFVVRRDPLDSHTFYLSVRCPEsVVVHLLVQWVPRQqQFELDHRACFADMQQLIKFY
||. . ..|   |||||....|.|.||       .. |||.  .  | |  .|   .. .. .  .. | ..|.|...|
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddg.kvkhyriqsleng.kyyitenekfsslqeLvehY