Gene VSP in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily VSP
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP031_AA protein Get Run
MbreP031_AA_511-715 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Amidohydro_2 Amidohydrolase 85-288 2.5e-24 72.6 Pfam-A 62-251 (273) alignment 
Range on Protein: 85-288
Range on HMM: 62-251/273.0
LAEQADIPLGIVGYANLADAQAPALVASMMEGNRGKYMRGIRMILNHNPSWPKVEHDEhltstefARGYAELAKHKLSFDLQ----------ANPHQLER
.|| |. | ...| | |..  ... || ...    .  .|...  ... ..|  ....        ..|. .....| ....          ....|.. 
aaeaakrpdrflggaalpprdpedavaelerrveelgfkGvklhphlgggdpdddrly.......rpiyeaaeelglpvqiHtgglggagetlraaqply

AAALAAKHPEVPMIVDHLGTLklnvegsaqrteaLANWRAGMHLLaAAGPHVYVKLSMLAYTesnWHEGSDATVDDLVHEVIALFGTDRCMLASNYPVDK
.. ||...|.......|.|                ...|. ..|| .  |.|||.|| |. .   ..  | .. .  . |.....| ||.. .|.||. .
leglarrfPkLkfvlaHaGgp.............fellrealrll.krypnvyvdlsglfpe...qstdspvadppalaelleevgpdrilFGsDyPhpp

AEFNVQPAQLWARV
 |. .. ..|.. .
genplealklldll
Virul_fac_BrkB Virulence factor BrkB 392-484 5.9e-06 12.1 Pfam-A 109-206 (260) alignment 
Range on Protein: 392-484
Range on HMM: 109-206/260.0
WWVHRVVDNIYTRLFGLLLVLIDVILVFVRLSNA-----HWKFNSHHKDPIAYDVVSTIIVVYFMIELCARIYAIGPRHFVRLPWEMFDALIVLVTFI
.. .|... ... |.||||.|  ...||.   .      ........   . . ........ ... |.| .| . |.. |.. . .  ||.. | ..
flrkrllslllllllglllllslalsvflksalladllpllgllleisellllqllrllvslllltllfallyrflpnrkvkwraalpGallaavlwl
Ion_trans Ion transport protein 442-517 1.4e-10 29.1 Pfam-A 2-84 (200) alignment 
Range on Protein: 442-517
Range on HMM: 2-84/200.0
VSTIIVVYFMIELCARIYAIGP--RHFVRLPWEMFDALIVLVTFIFEFAFEAGR-----VIILARLVRIFLILRLLSEQNKLK
. ....| |..| . .|.| |.  ....| || ..| |.||....  ......      .. ..||.|.. .|||.|   .|.
leyvftviftlemllkiialgfkkftylrdpwnilDflvvlpslvslilrllnkesaegllsvlrllrvlRllrlisrieglr
subfamily_VSP_pd Subfamily VSP 506-716 2e-116 381.3 In-house 2-212 (212) alignment 
Range on Protein: 506-716
Range on HMM: 2-212/212.0
ILRLLSEQNKLKRAARLLVSQNKRRYRQDGFDLDLTFVTDRVIAMSFPSSGRTAIYRNPIAEVARFFNTKFPNAYLIVNCCSERDYDHAFFNNSVKNCRI
|||||....||..||| |||.|||||.|||||||||.||.|.|||||||||....|||||.|||||..||....| .||.||||.||...|||.||...|
ilrlltqkrklekaarrlvsenkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkrili

DDHNVPPLNEIFSICREFQDFLSKDEKRVLAIHCKGGKGRTGTIICSWLLYSGMFTQAQEALDFFAERRTDKGVGNMFQGVQTPSQYRFVGYVEDIIQKY
|||||| |.|......|....|.||.|.||||||||||||||||.|..||.|..|..|.|.||.|.||||||..|..|||||||||.|.|||.|....||
ddhnvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvktky

NRIPPPTKTLH
||  ||.|||.
nrklppaktlk
0040438 (Phosphotyrosine protein) phosphatases II 512-715 2.4e-24 81.6 In-house 30-288 (317) alignment 
Range on Protein: 512-715
Range on HMM: 30-288/317.0
EQNKLKRAARLLVSQNKRRY-------------RQDGFDLDLTFV----------TDRVIAMSFPSSGRTAIYRNPIAEVarffntkfpNAYLIVNCCSE
 .    . |.|.....|.||               .|.|||....          ... ||...| .. .. . . . |          .  .||. ...
lkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweq.........gvtvivmLtel

RDYD---------------------------HaFFNNSVKNCRI-------------------DDHNVPP-LNEIFSICREFQDFLSkDEKRVLAIHCKG
 ...                           .   .  . . ..                   .||.||| .......... ...|. |.. ....||..
eelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsa

GKGRTGTIICSWLL-----YSGmFTQAQEALDFFAERRtdkgvgnmFQGVQTPSQYRFVGYVEDIIQKYNRIPPPTKTL
|.|||||.|. .|.     . | .  ..||.... |.|         ..||||.||||. ...  . |..   .| . |
GvgRtGtfiaaylmleqlekeg.gvdveeavkelreqR........pgavqtpeqyrflydalleylkrkltlepasel
0039614 (Phosphotyrosine protein) phosphatases II 515-699 2.7e-28 94.7 In-house 47-285 (297) alignment 
Range on Protein: 515-699
Range on HMM: 47-285/297.0
KlKRAARLLVSQNKRRYR--------------QDGFDLDLTFV-----------TDRVIAMSFPSSG-----RTAIYRNPIAEVA---------------
  .. |.| ....|.||.               ||.|||....           |...||...|...        .... .  .                
d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqy

-------------RFFNTKFPNAYLIVNCCSERdYDHAFFNNSVKNCRIDDHNVPP-LNEIFSICREFQDFLSKD-EKRVLAIHCKGGKGRTGTIICSWL
             .. ...  . | . . . .. ..  .. . .    . ||.||| |. ....... ...|... .... ..||..|.|||||.|. .|
wpeeggtygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaayl

LY----SGMFTQAQEALDFFAERRtdkgvgnmFQGVQTPSQYRFVGYVE
..    ..    ..||.... |.|         ..|||||||||. ...
mleqlekeggvdvleavkelreqR........pgavqtpsqyrflydal
0043336 (Phosphotyrosine protein) phosphatases II 515-698 2.7e-26 88.1 In-house 35-272 (278) alignment 
Range on Protein: 515-698
Range on HMM: 35-272/278.0
KLKRAARLLVSQNKRRY-------------RQDGFDLDLTFV----------TDRVIAMSFPSSGRTAIYRNPIAE------------------------
  .. |.|. ...|.||               .|.|||....          ....||...|... .. ... . |                        
dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYw

----------VARFFNTKFPNAYLIVNCCSER-DYDHAFFNNSVKNCRIDDHNVP-PLNEIFSICREFQDFLSkDEKRVLAIHCKGGKGRTGTIICSWLL
          . .. ...  . | . . . ..  ..  .. . .    . ||.|| .|. ...........|. |.. ....||..|.|||||.|. .||
pggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyll

Y----SGMFTQAQEALDFFAERRtdkgvgnmFQGVQTPSQYRFVGYV
.    .. .  ..||.... |.|        .. |||||||||. ..
leqlekeggvdleeavkelreqR........pgavqtpsqyrflyea
0045450 (Phosphotyrosine protein) phosphatases II 517-698 1.5e-23 79.5 In-house 47-299 (307) alignment 
Range on Protein: 517-698
Range on HMM: 47-299/307.0
KRAARLLVSQNKRRYRQ-------------------------------------DGFDLDLTFV----------------------------------TD
 ..|.|.....|.||.                                      ||.||...|.                                  ..
ysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgr

RVIAMSFPSSGRTAIYRNpiaEVARFFNTKFPNAYLIVNCCSERdYDHAFFNNSVKNCRI---DDHNVPP-LNEIFSICREFQDFLSKD-EKRVLAIHCK
. .|. .|..| .  |.|    . .. ...  . | . . . .. .|  ..   |.        ||.||| ..|......| ...|... .. . ..||.
ekcaqywPdegeeltygn...ftvtllseehldgytvrtlevtd.ldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCs

GGKGRTGTIICSWLLYSGMF-------TQAQEALDFFAERRtdkgvgnmFQGVQTPSQYRFVGYV
.|.|||||.|. .|.....          ..||.... |.|         ..||.|.||||. ..
aGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR........pgavqnpeqyrflyea
0046845 (Phosphotyrosine protein) phosphatases II 518-698 1.8e-22 75.5 In-house 21-269 (284) alignment 
Range on Protein: 518-698
Range on HMM: 21-269/284.0
RAARLLVSQNKRRYRQ-----------------------------DGFDLDLTFVTDRVIAMSFPSSG-----------------------------RTA
..|.|.  ..| ||..                             ||.||||| .. . ||...| ..                               |
svallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekca

IYRNPIAEVARF-------FNTKFPNAYLIVNCCSERD--YDHAFFNNSVKNCRIDDHNVPP-LNEIFSICREFQDFLSK-DEKRVLAIHCKGGKGRTGT
 |.... || ..        ...  . | . . . ..    .  .. .      . ||.||| .. .....|. ...|.. . . . ..||..|.|||||
qYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGt

IICSWLLYSGMFTQA-------QEALDFFAERRtdkgvgnmFQGVQTPSQYRFVGYV
.|. .||.. . ..        .||. .. |.|        .. |||..||||| ..
fialdllleqlekeglllgvdvleavkrlreqR........pgmvqtleqyrfvyea
0040439 (Phosphotyrosine protein) phosphatases II 519-698 2.2e-22 75.4 In-house 5-241 (249) alignment 
Range on Protein: 519-698
Range on HMM: 5-241/249.0
AARLLVSQNKRRYR---------------QDGFD--------LDLTFVTDRVIAMSFPSSGRTAIYRNPIAEvarffntkfPNAYLIVNCCSER------
 |.|.....|.||.               ...|.        .|.. ...|.||...| .. .. ... . |          .   ||...|.       
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwe.........lgitvivmLtslvelgrek

---------------------------------------DYDHAFFNNSVKNCRIDDHNVP-PLNEIFSICREFQDFLSKD-EKRVLAIHCKGGKGRTGT
                                        ..  .  . .    . ||.||  .......... ...|... .. ....||..|.|||||
caqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGt

IICSWLL-----YSGMFTqAQEALDFFAERRtdkgvgnmFQGVQTPSQYRFVGYV
.|. .|.     . . .. ..||.... ..|        ...||.|.||||. ..
fiaaylmleqlekelgvd.leeavkllrsqR........pgavqnpeqyrflyea
0037934 (Phosphotyrosine protein) phosphatases II 520-699 2.9e-27 91.2 In-house 5-238 (243) alignment 
Range on Protein: 520-699
Range on HMM: 5-238/243.0
ARLLVSQNKRRYR--------------QDGFDLDLTFVTDRVIAMSFPSSG---------RTAIYRNPIAEVA---------------------------
|.|.....|.||.               | ....|. ||.|.||...| ..            .... |  .                            
allpenlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdft

-RFFNTKFPNAYLIVNCCSER--DYDHAFFNNSVKNCRIDDHNVPP-LNEIFSICREFQDFLSK-------DEKRVLAIHCKGGKGRTGTIICSWLLYSG
 .. ...  . | . . . |.   .|. ...  .    . ||.||.  . . ....| ..|...       |.......||..|.|||||.|. .|... 
vtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmlll

MFTQAQEALDFFAERRTDkgvgnmfQGVQTPSQYRFVGYVE
.   ..||.... |.|          .|||||||||. ...
lgvdleeavkllreqRpg.......kavqtpsqyrflyeal
0042113 (Phosphotyrosine protein) phosphatases II 520-698 1.6e-25 85.4 In-house 4-238 (245) alignment 
Range on Protein: 520-698
Range on HMM: 4-238/245.0
ARLLVSQNKRRY-------------RQDGFDLDLTFV----------TDRVIAMSFPSSGRTAIYRNPIAEVarffntkfpNAYLIVNCCSER-------
|.|.....|.||               ||.|||....          |...||...|... .. . . . |          .   ||....|        
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwel.........gittivmLteeeelgrvkc

--------------------------------------DYDHAFFNNSVKNCRIDDHNVPP-LNEIFSICREFQDFLSKDEKRVLAIHCKGGKGRTGTII
                                       .|  .... .    ..||.||. |. ....... ...|..|.. ....||..|.|||||.|
aqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfi

CSWLLY----SGMFTQAQEALDFFAERRtdkgvgnmFQGVQTPSQYRFVGYV
. .|..    . .   ..||.... ..|         . |||||||||. ..
aaylmleqlekelgvsleeavkelrsqR........pgavqtpsqyrflyea
subfamily_PTEN_pd Subfamily PTEN 521-704 1.8e-63 208.8 In-house 3-181 (184) alignment 
Range on Protein: 521-704
Range on HMM: 3-181/184.0
RLLVSQNKRRYRQDGFDLDLTFVTDRVIAMSFPSSGRTAIYRNPIAEVARFFNTKFPNAYLIVNCCSERDYDHAFFNNSVKNCRIDDHNVPPLNEIFSIC
| .||..|.|...||.||||...|...|||..|. .  |.||| . .| .|...|. . | | | .|||.||.. |.. |. . .|||| |||. . .|.
rkivskkkkrfkedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeiv

REFQDFLSKDEKRVLAIHCKGGKGRTGTIICSWLLYSGMFTQAQEALDFFAERRTDKGvgnmfQGVQTPSQYRFVGYVEDIIQK
.. ...|..|.|.| ..||| ||||||..|...||.|.....|.|||..||| || ..     .||. ||| |.| |.|.....
ediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknk.....kgvtiPsqrRYveYyekllee
PTEN_1 523-702 8.3e-45 148.0 In-house 5-192 (196) alignment 
Range on Protein: 523-702
Range on HMM: 5-192/196.0
LVSQNKRRYRQDGFDLDLTFVTDRVIAMS-FPSSG-----RTAIYRNPIAEVARFFNTKFPN-AYLIVNCCSERD-----YDHA-FFNNSVK--NCRIDD
  . .|.........||||..|.|.|||. .|| .         ||... .||...... .. ..|.|| ..|..     ||.  ||.. |.  .. |.|
skrsskknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieD

HNVPPLNEIFSICREFQDFLSKDE-KRVLAIHCKGGKGRTGTIICSWLLYSGMfTQAQEALDFFAERRTDKGVGnmfqgvqTPSQYRFVGYVEDII
|..|.|.|.| ||..| . |..|. ..| ..|||.|.||.||.....|.|.|    |.|||....|.|.  ..        .||| |.. |.... 
hgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn.......spsqerlleyfaell
0044763 (Phosphotyrosine protein) phosphatases II 523-708 9.8e-23 76.1 In-house 6-176 (178) alignment 
Range on Protein: 523-708
Range on HMM: 6-176/178.0
LVSQNKRRYRQDGFDLDLTFVTDRVIAMSFPSsgrtaiyrnpiaevA-RFFNTKFPNAYLIVNCCSE--------RDYDHAFFNNSVKNCRIDDHNVPPL
.|. ..... . .. .............|.|.              |  .   |  .  .|||...|          |.   ..  .... |.||.||.|
rvllsnleglersdyinaseilpglylgslpp..............addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdl

NEIFSICREFQDFLSKDEKRVLAIHCKGGKGRTGTIICSWLLYSGMFtQAQEALDFFAERRtdkgvgnmFqGVQTPSQYRFVGYVEDIIQKYNRI
 |.|  . || . . ...... ..||. |.||.||... .|...  .  ..||.... |||        . .|..|.|.|.. ..| ...|.. .
lehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkklgl.sleeaielvrerR........p.ivpnpgqlrqLyefelrllkesdl
0041856 (Phosphotyrosine protein) phosphatases II 526-708 6.2e-30 99.5 In-house 2-176 (182) alignment 
Range on Protein: 526-708
Range on HMM: 2-176/182.0
QNKRRYRQ---DGFDLDLTFVTDRVIAMSFPSSGRTAIYRNPIAEVARFFNTKFPNAY-LIVNCCsERDYDHAFFNN---SVKNCRIDDHNVPPLNEIFS
..|.||.      ...||..........|.|..   | ..... .||.|...   . . .|||.. |. |.  ....    ...  ..||.||.|.|...
ldknrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpdldelld

ICREFQDflskdEKRVLAIHCKGGKGRTGTIICSWLLYSGmFTQAQEALDFFAERRtdkgvgnmFQGVQTPSQYRFVGYVEDIIQKYNRI
...| ..     |... ..||..|.|||||... .|...     ..||.... .||        ...|.||.||.|. ...  ..... .
fieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrR........pgmvitpnqyfflqlallellllkkt
subfamily_Tensin_pd Subfamily Tensin 529-706 6.1e-42 136.2 In-house 2-175 (189) alignment 
Range on Protein: 529-706
Range on HMM: 2-175/189.0
RRYRQDGFDLDLTFVTDRVIAMSFPSSGRTAIYRNPIAEVARFFNTKFPNAYLIVNCcSERDYDHAFFNNSVKNCRIDDHNVPPLNEIFSICREFQDFLS
 || .. .|||||..|.|.||.|||..|  . ||. . .||.....|  . ||. |  ||. ||   .|. | .    |.  |.|. . |||.... .|.
vryveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnl.sekrydisklnkkvldfGWPdllaPsleklcsicksldsWlk

KDEKRVLAIHCKGGKGRTGTIICSWLLYSGMFTQAQEALDFFAERRTdkgVGNMFQGVQTPSQYRFVGYVEDIIQKYN
.| ..|...||||||||.| .. ... || . . |..||| || .|    . .  .|.. ||| |.| |......   
adpqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrf...lddklsgetqPsqrryveyfsglLsgki
0046846 (Phosphotyrosine protein) phosphatases II 530-702 3.8e-31 103.6 In-house 2-172 (176) alignment 
Range on Protein: 530-702
Range on HMM: 2-172/176.0
RYRQDGFDLDLTFVTDRVIAMSFPSSGRTAIYRNPIAEVARFFNTkfpNAYLIVNCCSERDYDH-------AF---FNNSVKNCRIDDHNVPPLNEIFSI
|.|..|.||||.......|..|.|  .   ..|.  . ......    . ...||...|.....            ..  .... ..||.||.|. ....
rlrllgldldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllel

CREFQDFLSKDekRVLAIHCKGGKGRTGTIICSWLLYSGMFTQAQEALDFFAERRTDkgvgnmfQGVQTPSQYRFVGYVEDII
... ...|...  .. ..||..|.|||||... .||.....  ..|||... |.|         . ||||.||||. ..|  .
lefirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl.......gavqtpeQyrflyefelll
0043147 (Phosphotyrosine protein) phosphatases II 530-703 3.9e-28 93.7 In-house 5-161 (172) alignment 
Range on Protein: 530-703
Range on HMM: 5-161/172.0
RYRQDGFDLDLTFVTDRVIAMSFPssgrtaiYRNPIAEVARFFNTKFPNAylIVNCCsER---DYDHAFFNNSVKNCRIDDHNVPPLNEIFSICREFQDF
..  . ..|||....||.||. .|       .||..|.. |.. ..  ..  |||.. |.    ..   ..  .  . ..||.||.|. . ....  ...
sdyinasyldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnlt.ellydpellerlgiqylylpwpDhgvpllellleflefidel

LSKDEKRVLAIHCKGGKGRTGTIICSWLLYSGMftQAQEALDFFAERRtdkgvgnmFQGVQTPSQYRFVGYVEDIIQ
| .... . ..||..|.|||||... .|.. |.   ..||.... |.|        ...||.||||||. | |... 
lalspggpvlVHCsaGvgRtgtlvaaylmllgl..sleeavalvrekR........pgavqnpsqyrflyyfeklll
0045098 (Phosphotyrosine protein) phosphatases II 534-701 1.2e-20 69.6 In-house 3-270 (278) alignment 
Range on Protein: 534-701
Range on HMM: 3-270/278.0
DGFDLDLTFVTDRVIAMSFPSSGRTAIYRNPIA-------------------------------------------------------------------
....|||.  .........||.  .|.|.....                                                                   
alasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelg

------------------------EVARFfNTKFPNAYLIVNCCSERDYDHAFFNNSVKNCRIDDHNVPPLN---EIFSICREFQDFLS-----------
                        .. .. ..     .|..|...|| ..  .. . ..   ..||.||.|.    ....... ...|.           
rekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssll

-KDEKRVLAIHCKGGKGRTGTIICSWLLYSGMfTQAQEALDFFAERRTDKgvgnMFQGVQTPSQYRFVGYVEDI
  |.. . ..||. |.|||||... .|... .  .   .|. ..| |. .    ... ||...||||. ...  
lldsggpvlVHCsaGvgRtGtlvaaylmlell.eggvdlleavkelrsqR....pglavqnleqyrflyeflle
0036282 (Phosphotyrosine protein) phosphatases II 536-701 2.9e-38 126.6 In-house 8-168 (174) alignment 
Range on Protein: 536-701
Range on HMM: 8-168/174.0
FDLDLTFVTDRVIAMSFPSSGRTAIYRNPIAEVARFFNTKFPNAYLIVNCCSERDYDHAFFNNSVKNCRIDDHNVPPLNEIFSICREFQDFLSKDEKRVL
..|||. .|.|.||...| .    .... |  | .. . | .. |.. | ..|. .|   ..  .. . ..||.||.|......... ...||.|.....
spldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpv

AIHCKGGKGRTGTIICSWLLYSGMFTQAQEALDFFAERRTdkgvgNMFQGVQTPSQYRFVGYVEDI
..||..|.|||||... .|.. |... ...|||...|.|.        ..|||||||||. |.|..
lVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRl.....qrpgmvqtpsQyrflyyfekl
subfamily_Auxilin_pd Subfamily Auxilin 537-703 1.4e-41 135.0 In-house 8-165 (166) alignment 
Range on Protein: 537-703
Range on HMM: 8-165/166.0
DLDLTFVTDRVIAMSFPSSGRTAIYRNPIAEVARFFNTKFPNAYLIVNCcSERDYDHAFFNNSVKNCRIDDHNVPPLNEIFSICREFQDFLSKDEKRVLA
|||....| |.| ||||. |    |.| | .|. | ....|. ||..|  |.|.|..| ... | .. .  ...|.|......||... .| ||.|.|. 
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynl.sqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvv

IHCKGGKGRTGTIICSWLLYSGMFTQAQEALDFFAERRTDKGvgnmfqgvQTPSQYRFVGYVEDIIQ
.||| |.  ........|..  .......|...|. .|. .|         .||. |.. |. |...
vhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig........lspsekryleyladlla
0051082 (Phosphotyrosine protein) phosphatases II 538-694 2.4e-22 74.6 In-house 6-144 (151) alignment 
Range on Protein: 538-694
Range on HMM: 6-144/151.0
LDLTFVTDRVIAMSFPSSgrtaiyrnpiaEVARFFntKFPNAYLIVNCCS--ERDYDHAFFNN---SVKNCRIDDHNVPPLNEIFSICREFQDFLSKDEK
.....||........|..           .. ...  |  . . |||..|  ||.|.. ....    |... |.|. .|.| ..| ...|| ..| ....
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

RVLAIHCKGGKGRTGTIICSWLLYSGmfTQAQEALDFFAERRTdkgvgnmfQGVQTPSQYRF
 ....||..|||||||... .|.. |    ..|||... ..|.          ||.. |..|
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp........gvvqpnqqflf
0038934 (Phosphotyrosine protein) phosphatases II 542-706 2.4e-32 107.5 In-house 15-174 (194) alignment 
Range on Protein: 542-706
Range on HMM: 15-174/194.0
FVTDRVIAMSFPSSG-----RTAIYRNPIAEVARFFNTKFPNAYLIVNC-CSERDYDHAFFNN---SVKNCRIDD-HNVPPLNEIFSICREFQDFLSKDE
..|.|.||...|.||      . .||...  . |.....  . .|...  ..|| ||.  | .    . .. . | ..||.|. ......  ..||..|.
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

KRVLAIHCKGGKGRTGTIICSWLLYSGMFtQAQEALDFFAERRtdkgvgnmfqgvqtPSQYRFVGYVEDIIQKYN
. | |.|||.|.|||||.....|.|.  .  |.||...|.|.|              |.... ..|.|.. . |.
ggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekR..............pgaipnqdyleallkryk
0049772 (Phosphotyrosine protein) phosphatases II 546-697 2.1e-18 62.6 In-house 122-274 (314) alignment 
Range on Protein: 546-697
Range on HMM: 122-274/314.0
RVIAM---------------------SFPSSGRTaiyrnPIAEVARFFNTKfpnaylivnccsERDYDHAFFNNSVKNC---RIDDHNVPPLNEIFSICR
|.| |                       . .|..     ..  .|.. . |            |. ||. .| . . .     ..|...|.|. . ....
rdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk............eelydpelferlgikylripvpDgsaplledfdefle

EFQDFlskDEKRVLAIHCKGGKGRTGT-IICSWLLYSGMFtQAQEALDFFAERRTdKGVGNMFQgvQTPSQYRFVGY
 ....   |.......|||.||||||| ... .|..   .  ..|||... ..|.  .    |   ... || |. .
fieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp.inpnpgfi..eqleqyefile
0049260 (Phosphotyrosine protein) phosphatases II 548-701 7.2e-28 92.6 In-house 5-148 (152) alignment 
Range on Protein: 548-701
Range on HMM: 5-148/152.0
IAMSFPSSGRTAIYRNPIAEVARFFNTKFPNAYLIVNCCSERDYDHAFFNNSVKNCRIDDHNVPPLNEIFSICREFQDFLSKDEKRVLAIHCKGGKGRTG
.||.|.  .  ....|..|.. |.. .   .... .. ..|....   .   .... ..||.||.| ... .. .| ..| .|.. . ..||..|.||||
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtg

TIICSWLLYsgMFTQAQEALDFFAERRtdkgvgnmFQGVQTPSQYRFVGYVEDI
|... .|..  .   ..||.... |.|         ..|..|.|.||. ..|..
tlvaaylml..lgvsleeavalvrekR........pgavpnpgqlrflyefekl
0048179 (Phosphotyrosine protein) phosphatases II 552-701 7.5e-22 73.0 In-house 3-143 (144) alignment 
Range on Protein: 552-701
Range on HMM: 3-143/144.0
FPSSGRTAIYRNPIAEVARFFNTKFPNAYLIVNCCSERDYDHAFFNN-SVKNCRIDDHNVPPL-NEIFSICREFQDFLSKDekRVLAIHCKGGKGRTGTI
.||     .|....  . .. . |  . ....|...|.....  ...  . .. ..||.||.| . . .... ....|...  .. ..||..|.|||||.
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtl

ICSWLLYSGMfTQAQEALDFFAERRTdkgvgnmfQGVQTPSQYRFVGYVEDI
.. .|..      ..|||... .||         ..|..|.|.||. . |..
vaaylmkklg.lsleealalvrsrrp........gavpnpgqlrfLleyekl
0048076 (Phosphotyrosine protein) phosphatases II 552-701 2.6e-21 71.2 In-house 3-141 (145) alignment 
Range on Protein: 552-701
Range on HMM: 3-141/145.0
FPSSGRTAIYRNPIAEVARFFNTKFPNAYLIVNCCSERDYDHaFFNNSVKNCRIDDHNVPPL-NEIFSICREFQDFLSKDekRVLAIHCKGGKGRTGTII
.||     .|....  . .. . |  . ....|..||...    ..  . .. ..||.||.| . . ....  ...|...  .. ..||. |.|||||..
wpseilpglylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlv

CSWLLYSGMfTQAQEALDFFAERRtdkgvgnmFQGVQTPSQYRFVGYVEDI
. .|...     ..|||... ..|        ...|..|.|.||. ..| .
aaylmlllg.vsleealelvrsqr........pgavpnpgqlrflyefele
0047943 (Phosphotyrosine protein) phosphatases II 574-696 1.4e-15 53.0 In-house 144-265 (273) alignment 
Range on Protein: 574-696
Range on HMM: 144-265/273.0
TKFPNAYLIVNCCSER-DYDHAFFNNSVKNCRIDDHNVP-PLNEIFSICREFQDFLSKD-EKRVLAIHCKGGKGRTGTIICSWLL-----YSGMFTqAQE
..  . | . . . .. .... .. . .    . ||.||  |......... ...|... .. . ..||..|.|||||.|. .||     . |... . |
eetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd.vle

ALDFFAERRtdkgvgnmFQGVQTPSQYRFVG
|. .. ..|        . .||||.||||. 
avkllrsqR........pgmvqtpeqyrfly
subfamily_PRL_pd Subfamily PRL 577-675 2e-08 28.4 In-house 33-131 (151) alignment 
Range on Protein: 577-675
Range on HMM: 33-131/151.0
PNAYLIVNCCsERDYDHAFFNN---SVKNCRIDDHNVPPLNEIFSICREFQDFLSKDEKRVLAIHCKGGKGRTGTIICSWLLYSGMftQAQEALDFFAER
 ..  .| .| |  || . ...   .|..   || .||| . . .  .  ..  ... |...|.||  | ||.  ...  |. .||  . ..|..|  |.
eevktvvrvc.eptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm..kyedavefirek

RT
| 
rr
0051299 (Phosphotyrosine protein) phosphatases II 578-696 2.9e-15 51.9 In-house 160-279 (288) alignment 
Range on Protein: 578-696
Range on HMM: 160-279/288.0
NAYLIVNCCSER-----DYDHAFFNNSVKNCRIDDHNVPP-LNEIFSICREFQDFLSkDEKRVLAIHCKGGKGRTGTIICSWLLYSGM-FTQAQEALDFF
. | . . . ..       .  .. .      . ||.||. ........|.....|. . . . ..||. |.|||||.|. .||.. . ...  ..|...
ddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleav

AERRTDKGVgnmfqGVQTPSQYRFVG
.  |. .        ||||.||||| 
krlreqRpg.....mvqtpeqyrfvy
0050432 (Phosphotyrosine protein) phosphatases II 579-695 5.1e-13 44.5 In-house 167-291 (308) alignment 
Range on Protein: 579-695
Range on HMM: 167-291/308.0
AYLIVNCCSERDYDHAFFNNSVKN--------------CRIDDHNVPP-LNEIFSICREFQDFLskdEKRVLAIHCKGGKGRTGTIICSWLLYSGM-FTQ
 . . . . | . |.  ..  ..|                  ||.||| .......... ...|   .. . ..||. | |||||.|. .||.. .  ..
kftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeg

AQEALDFFAERRTDKgvgnmFQGVQTPSQYRFV
   ... ..  |. .      . ||||.||.|.
gvdvfeavkklReqR.....pgmvqtpeqylfl
DSPc Dual specificity phosphatase, catalytic domain 582-677 2.6e-10 35.3 Pfam-A 22-116 (133) alignment 
Range on Protein: 582-677
Range on HMM: 22-116/133.0
IVNCCSERDYDHA--FFNNSVKNCRIDDHNVPPLNEIFSICREFQDFLSKDEKRVLaIHCKGGKGRTGTIICSWLLYSGMFtQAQEALDFFAERRtDK
..|. .| . ..|    ..   .. ..|..   . . .. . || . . ...|.|| .||. |  |..|.|. .|...  . ...||..|. ||| .|
vinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvl.VHCqaGisRSatliiaYlmktknl.slneAyefvkerr.sk
DSPc Dual specificity phosphatase, catalytic domain 582-677 2.6e-10 35.3 In-house 22-116 (133) alignment 
Range on Protein: 582-677
Range on HMM: 22-116/133.0
IVNCCSERDYDHA--FFNNSVKNCRIDDHNVPPLNEIFSICREFQDFLSKDEKRVLaIHCKGGKGRTGTIICSWLLYSGMFtQAQEALDFFAERRtDK
..|. .| . ..|    ..   .. ..|..   . . .. . || . . ...|.|| .||. |  |..|.|. .|...  . ...||..|. ||| .|
vinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvl.VHCqaGisRSatliiaYlmktknl.slneAyefvkerr.sk
PTPc_motif_SM00404 582-677 7.8e-09 30.5 In-house 31-123 (140) alignment 
Range on Protein: 582-677
Range on HMM: 31-123/140.0
IVNCCSERDYDHAFFNNSVKNCRIDDHNVPPLNEIFSICREFQDFLSKDEKRVLaIHCKGGKGRTGTIICSWLLYSGMFtQAQEALDFFAERRtDK
..|. .| . . .  .  .... .||... .| . .. . .| .   |....|| .||. |  |..|.|. .|...  . ...||..|. ||| ..
vinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvl.VHCqaGvSRSatliiaYlmryrql.slaeayefvkerR.pi
subfamily_DSP1_pd Subfamily DSP1 582-675 2.1e-06 21.9 In-house 47-137 (163) alignment 
Range on Protein: 582-675
Range on HMM: 47-137/163.0
IVNCCSERD--YDHaffNNSVKNCRIDDHNVPPLNEIFSICREFQDFLSKDEKRVLaIHCKGGKGRTGTIICSWLLYSGMFtQAQEALDFFAERRT
|.|. .| |  ...     . |.  ..|..   . ..|.   || |   | . .|| |||. |  |  |..  .|. .  . . .|| ||  .||.
ilnvskeldnvfed...lfeYkklkleDspkadislvfeeviefidevkkknGkvl.ihCqaGisRsstlclaylmktkrv.sleeafdfvkqrRs
subfamily_DSP11_pd Subfamily DSP11 588-674 2.6e-09 31.2 In-house 67-157 (178) alignment 
Range on Protein: 588-674
Range on HMM: 67-157/178.0
ERDYDHAFFNNS-VKN--CRIDDHNVPPLNEIFSICREFQDFL--SKDEKRVLAIHCKGGKGRTGTIICSWLLYSgMFTQAQEALDFFAERR
.| |..  .... ||    ..  |.||  . . . ... ..||  .||.......||  |  ||| .|| .|.   .  ....|.. | | |
dryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidv.egyepedaieafeear
subfamily_RNGTT_pd Subfamily RNGTT 589-675 1e-08 29.1 In-house 66-155 (189) alignment 
Range on Protein: 589-675
Range on HMM: 66-155/189.0
RDYDHAFFNN-SVKNCRID--DHNV-PPLNEIFSICREFQDFLSKDEKRVLAIHCKGGKGRTGTIICSWLLYSGMFtQAQEALDFFAERRT
| ||.  ...  .|  ...   . . |  ... .. .  ..| .|  ..|...||. |  ||| .|.|.|.    . ....|.. ||. | 
ryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedw.sveaavalFakaRp
subfamily_DSP23_pd Subfamily DSP23 589-660 3.1e-06 21.9 In-house 43-112 (148) alignment 
Range on Protein: 589-660
Range on HMM: 43-112/148.0
RDYDHAFFNNSVKNCRIDDHNVPPLNEIFSICREFQDFLSKDEkrVLAIHCKGGKGRTGTIICSWLLYSGMF
|   .|  | .... ||||.  | |...  . |  ..  .|.|   ...||  |.|||||..  .|.    .
rphveatpnltlvrlriddyhppaleqvvefvrvveeaeekne..avsvhcllgrgrtgtmlacylvkerkl
subfamily_PTPDC1_pd Subfamily PTPDC1 600-676 2.2e-12 41.8 In-house 85-157 (182) alignment 
Range on Protein: 600-676
Range on HMM: 85-157/182.0
VKNCRIDDHNVPPLNEIFSICREFQDFLSKDekrVLAIHCKGGKGRTGTIICSWLLYSGMFTqAQEALDFFAERRTD
| |. ..|..|..|..|. | .  .  |...    .|.||  |.|||| .|...|.|.  .| |..|...  ..|..
vynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyakrlt.aekaiklvrskrpk
0051429 (Phosphotyrosine protein) phosphatases II 602-703 2.3e-11 39.4 In-house 127-226 (272) alignment 
Range on Protein: 602-703
Range on HMM: 127-226/272.0
NCRIDDHNVPP--LNEIFSICREfqdflskdeKRVLAIHCKGGKGRTGTIICSWLLYSGMFTQ------------AQEALDFFAERRtdkgvgnmFQGVQ
 ... ||.||.  | |.......         .. . .||..||.||||... .||. |.  .            ..||..   ..|         . ||
ytdwpdhgvpqeallellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqr........pgavq

TPSQYRFVGY-VEDIIQ
|. ||.|.   . ... 
teeqylflyeallellr
subfamily_PTPMT1_pd Subfamily PTPMT1 602-675 1.9e-08 28.9 In-house 78-149 (171) alignment 
Range on Protein: 602-675
Range on HMM: 78-149/171.0
NCRIDDHN-VPPLNEIFSICrEFQDFLSKDEKRVlAIHCKGGKGRTGTIICSWLLYSGMFTqAQEALDFFAERRT
. .. |.   | |....    || .   .. |||  .|||.|.||..|.. ..|...  ..  .|||.. ...| 
qlatvDfteapdleklekgv.efiekvaskgkrv.YvHCkaGrgRsatlvacylmkkekls.peeAlkalkkkRk
0036941 (Phosphotyrosine protein) phosphatases II 603-706 1.3e-13 46.3 In-house 176-280 (297) alignment 
Range on Protein: 603-706
Range on HMM: 176-280/297.0
CRIDDHNVPP-LNEIFSICREFQDFLSKD-EKRVLAIHCKGGKGRTGTIICSWLL--------YSGMFTqAQEALDFFAERRtdkgvgnmFQGVQTPSQY
  ..||.||.  .............|..  .. .  .||..|.||.||.|. .|.        . | ..   ||. .. |.|        .. |||..||
tgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvd.ileavkklReqR........pgavqtleqy

RFVGYVEDIIQKYN
||. ...    |..
rflyeallellkkk
PTPc_DSPc_SM00012 605-695 1.1e-09 33.8 In-house 10-99 (105) alignment 
Range on Protein: 605-695
Range on HMM: 10-99/105.0
IDDHNVPP-LNEIFSICREFQDFLSKDE-KRVLAIHCKGGKGRTGTIICSWLLYSGMFTQA--QEALDFFAERRtdkgvGNMFQGVQTPSQYRFV
. ||.||   ..|....|..... .| | .  . .||. | |||||...  .|.. . ..    . .... | |         . |||  || |.
wpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelr.....kqRpgmvqteeqylfl
subfamily_CDC14_pd Subfamily CDC14 606-669 8.7e-08 26.4 In-house 242-299 (328) alignment 
Range on Protein: 606-669
Range on HMM: 242-299/328.0
DDHNVPPLneifSICREFQDFLSKDeKRVLAIHCKGGKGRTGTIICSWLLYSGMFTqAQEALDF
 |  .|.     .| ..| . . |  .  .|.||| | |||||.| ..|..   || |.||. .
iDGstPsd....aivkkfleiaeka.eGaiavhCkaGLGrtGtLiacylmkhyrft.aaeaiaw
subfamily_PTPN12_pd Subfamily PTPN12 606-696 4.7e-07 24.0 In-house 181-270 (290) alignment 
Range on Protein: 606-696
Range on HMM: 181-270/290.0
DDHNVPP-LNEIFSICREFQDFLSkDEKRVLAIHCKGGKGRTGTIICSWLLYSGMFTQAQ-EALDFFA---ERRTDKGvgNMfqgVQTPSQYRFVG
 ||.||   ...... ...... . .|.  |..||  | |||||||   . .. . ..   | || |    | |...    .   |||  ||..| 
PDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqra..al...vqtkeqyelvy
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 607-697 4e-07 24.4 In-house 190-277 (319) alignment 
Range on Protein: 607-697
Range on HMM: 190-277/319.0
DHNVPP-LNEIFSICREFQDFLSKDEKRVLAIHCKGGKGRTGTIICSWLLYSGMftQAQEALDFFAERRTDKGVGNMFqgVQTPSQYRFVGY
||.||  .  .  . .. .   .| ... . .||  | ||||| |        .  . ...|| |   .. .   |.   ||.|.||.|. .
dhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlerv..keegvlDvfstvsrlRtqRnim..vqrpeqYkfiye
0048567 (Phosphotyrosine protein) phosphatases II 607-674 7.3e-07 23.7 In-house 47-118 (157) alignment 
Range on Protein: 607-674
Range on HMM: 47-118/157.0
DHNVPPLNEIFSICREFQDFLS--KDEKRVLAIHCKGGK---GRTGTIICSWLLYSGMFTqAQEALDFFAERR
|.  ..|. ... .. . .||.  . .....|.||| |    |||.|.|...|..   || ..||.....  |
dfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgft.peeaiaplrivr
subfamily_PTPN14_pd Subfamily PTPN14 613-696 9.8e-06 19.8 In-house 209-289 (300) alignment 
Range on Protein: 613-696
Range on HMM: 209-289/300.0
LNEIFSICREFQDFL-SKDEKRVLAIHCKGGKGRTGTIICSWLLYSGMftQAQEALDFFAERRTDKGvgNMFQGVQTPSQYRFVG
|.|. |..|....   ||..|  . .||  | |||| .| | || . .  . .| .|     .. .        ||| .||.|| 
LeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatl..ehneeidikkvlarLre..qrmllvqtlaqYkfvY
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 785-822 2.8e-09 28.3 Pfam-A 62-99 (134) alignment 
Range on Protein: 785-822
Range on HMM: 62-99/134.0
SGTAVRQDVKTMFYSEDLPAYYDKCPFYFWFNTGFVPE
 .  |. ||.  |...|   ..... |..|||| |...
nrlpveGDvlveflhkdsklpkkekifrvwFNTsFiek
LIM LIM domain 851-906 7.4e-16 46.1 Pfam-A 1-56 (58) alignment 
Range on Protein: 851-906
Range on HMM: 1-56/58.0
CPSCGKSVYFAEKH-TALGKDWHKMCLKCEKCKKILANGSFLEHGGKPYCQKpCYEA
| .|.| .. .|    ||||..|. |..|..|.| |...|| |. ||.||.| .|  
CagCnkkiadrelvlkalgkvyHeeCFtCseCqkplkeksffekdgklyCkk.dylk