Gene MbrePTP-sf1-3 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily MbrePTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP034_AA protein Get Run
MbreP034_AA_14-288 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0039614 (Phosphotyrosine protein) phosphatases II 13-291 6.9e-84 277.1 In-house 15-293 (297) alignment 
Range on Protein: 13-291
Range on HMM: 15-293/297.0
TFTNIRKLCAQRNQNQGAGFVTDFQALASIGVGnpSTASKAPENIVKNRYVNITAYDASRVVLKD-----HDTDYINASWCPSYTS-PRGFIATQGPVPS
. . .  |.  ...|.  .. ..|. | |. .    . .. |||. ||||..| .|| |||.||.     .|.||||||. . |   .| ||||||| |.
plsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe

SFDDFWWMIWSYKVGEIVMVTRELETNVlKCHRYWPEDNAevQYGKVKVKFTRSAMHAHHIERHFEVGLasGGPTRDVVQLAFQSWPDHGVPLTSVEFLE
...|||.|.| ..|  |||.|.. | .. ||..||||.    .||...|....  .... . |..||    .|..| | .. . .||||||| ..  .||
tvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellle

FRAEVLKFHERD-TKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNNWL
|  .| ......  . |...|||||||||||.||....|.|.... .|... .. .||..|. .|||  || ......|. |.. |
flelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 13-288 6.5e-80 263.5 In-house 10-291 (298) alignment 
Range on Protein: 13-288
Range on HMM: 10-291/298.0
TFTNIRKLCAQRNQNQGAGFVTDFQALASIGV---GNPSTASKAPENIVKNRYVNITAYDASRVVLKD----HDTDYINASWCPSYTSPRGFIATQGPVP
. . ..|| | ..... .|. ..|| | |.      . ......|||  |||| .| |.| |||||..    ...||||||.  .|.    |||||.|..
lkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPlt

SSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNAEvQYGKVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFL
... ||| |.. ...| |||.|   |.. .|.|.|||....| .||...|.  ..  .|  | |...|  ..   .| |.|| | ||||.||| ..   |
etvedFWrmvteedigtiVmltnleeldktkyhkywPdegke.tygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvl

EFRAEVLKFHERDTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALN
.....| . ...  ..|. ..|||||||.||.||||. |..|..   | .  ..  ||..|  .||| .||......||.||.
dllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
0051299 (Phosphotyrosine protein) phosphatases II 15-287 5.3e-88 290.5 In-house 8-286 (288) alignment 
Range on Protein: 15-287
Range on HMM: 8-286/288.0
TNIRKLCAQRNQNQGAGFVTDFQALASIGVGNPSTASKAPENIVKNRYVNITAYDASRVVLKD----HDTDYINASWCPSYTSPRGFIATQGPVPSSFDD
....||. .. .|. .|.   |..| |. . .. .|.. |||. ||||..| .|| |||.|..    ...||||||. . | ..| ||||||| |....|
eellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntved

FWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEdNAEVQYGKVKVKFTRSAMHAHHIERHFEVGLA----SGGPTRDVVQLAFQSWPDHGVPLTSVEFLE
||.|.| ..|  |||.|.. | .. ||..|||. .  ..||...|....  .... . |..||        .| .| | .. . .||||||| .  ..|.
FWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellld

FRAEVLKFHErDTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDAL
|  .| |... ... |...|||||||||||.||.|..|.|.... .|..  .. .||..|..||||. || .|....|..|
flrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPRD_pd Subfamily PTPRD 16-333 1.7e-96 319.1 In-house 9-320 (564) alignment 
Range on Protein: 16-333
Range on HMM: 9-320/564.0
NIRKLCAQRNQNQGAGFVTDFQALASIgVGNPSTASKAPENIVKNRYVNITAYDASRVVL----KDHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDF
.... .|. ..|... | .... . .     . .|...|.|  |||| ||.|||.|||||    .|...||||||.. .|.... .||||||......||
elkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedF

WWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNaEVQYGKVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEV
| |.| ...  |||.|.  | .  |||.||||.. . .||...|... .   |. . |.|..  ..   .| | |  | |||||||| .  ..|... .|
WRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkv

LKFHeRDTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNNwlkKHKDiIDRERERmaaEQAR
 . . .... || .|||||||||||.|.||  |....| . |.|  .. .||..||.||||  ||...|...|.||.     ... .. |. .   .. .
raln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac...gnte.vesenlk...qhlq

ELEKQRQEQLAAAAAAEVQRRT
.|.......  .  ..| || .
kLaeveedtemtgleleFqrLa
0040438 (Phosphotyrosine protein) phosphatases II 16-291 6e-85 280.6 In-house 4-280 (317) alignment 
Range on Protein: 16-291
Range on HMM: 4-280/317.0
NIRKLCAQRNQNQGAGFVTDFQALASIGVGnPSTASKAPENIVKNRYVNITAYDASRVVLKD----HDTDYINASWCPSYTSPRGFIATQGPVPSSFDDF
.. ... ......  ..   |. | |. .  . . .. |||. ||||..|  ||.|||.|..    .|.||||||. . .  .| ||||||| |....||
dlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WWMIWSYKVGEIVMVTRELETNVLKCHRYWPEdNAEVQYGKVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEV
|.|.| ..|. |||.|.. | .. ||..|||. . ...||...|...    .|. . |..||    ....| | .. . .||||||| .  ..|.|  .|
wrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleav

LKFHErDTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNNWL
 .. | | . |...|||||||||||.||....|.|.... .|... .. .||..|. .||| .|| ......|. |.. |
reale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkl
0045450 (Phosphotyrosine protein) phosphatases II 16-287 2.1e-83 275.9 In-house 13-304 (307) alignment 
Range on Protein: 16-287
Range on HMM: 13-304/307.0
NIRKLCAQRNQNQGAGFVTDFQALASIGV--GNPSTASKAPENIVKNRYVNITAYDASRVVLKD-----HDTDYINASWC--------PSYTSPRGFIAT
.. .|.... ..  .|.   |. | |. |   .. .... |||. ||||..| .|| .||.|..     .|.||||||.         ..| ..| ||||
kllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIat

QGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNAEVQYGKVKVKFTRSAMHAHHIERHFEVGLA-SGGPTRDVVQLAFQSWPDHGVPL
||| |....|||.|.| ..|. |||.|.. | .  ||..|||... |..||...|....   ... . |..||      |..| | .. . .||||||| 
qgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp

TSVEFLEFRAEVLKFHERD-TKAPICIHCSAGVGRTGTYIAIDTALQQVQERAE---VNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDAL
.  |.|.|  ||.|..|..  . |...|||||||||||.||....|.|.... .   |... .. .||..|  .||.  || ......|. |
sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0043336 (Phosphotyrosine protein) phosphatases II 16-285 1.1e-81 269.6 In-house 6-275 (278) alignment 
Range on Protein: 16-285
Range on HMM: 6-275/278.0
NIRKLCAQRNQNQGAGFVTDFQALASIGVgNPSTASKAPENIVKNRYVNITAYDASRVVLKDHD----TDYINASWCPSYTSPRGFIATQGPVPSSFDDF
.. |...... |  ...  .|. | |. . .. . .. |||. ||||..| .|| |||.|.. .    .||||||. . |  ||.||||||| |....||
dllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedF

WWMIWSYKVGEIVMVTRELETNVLKCHRYWPedNAEVQYGKVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEV
|.|.| ..|  |||.|.. | .. ||..|||  .  ..||...|....   ... . |..||     |..| |... . .||||||| .   .|.|  .|
wrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkav

LKFHErDTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLD
... | | . |...|||||||||||.||....|.|.. . .|... .. .||..|  .|||  || ......|.
reale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 16-291 4.5e-76 251.0 In-house 9-287 (319) alignment 
Range on Protein: 16-291
Range on HMM: 9-287/319.0
NIRKLCAQRNQNQGAGFVTDFQALASiGVGNPSTASKAPENIVKNRYVNITAYDASRVVLKD----HDTDYINASWCPSYTSPRGFIATQGPVPSSFDDF
.... . . ...   ..  .|. |   .| .  . .. .||  |||| || ||| .||||..    ...||||||.  .|   . |||||.|.   ..||
eLkerlkalastgetllekefkllke.avndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedf

WWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNAeVQYGKVKVKFTRSAMHAHHIERHFEVGLASGGP-TRDVVQLAFQSWPDHGVPLTSVEFLEFRAE
| |.| ...  .||.|.  |   .|...|||| |  ..||.. |.       .. | |....  .|.   ||.|..  ...||||.|| ..   |..  .
WrmvWeeessivvmltklveklkvklkkywpeenf.eeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkr

VLKFHERDTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNNWL
. | .|. .. || .|||||||||||.|..| .|..|.| . ...  .. .||  ||.|||. .|| ......|.|..   
irksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_PTPN6_pd Subfamily PTPN6 16-289 2.6e-68 225.3 In-house 12-299 (306) alignment 
Range on Protein: 16-289
Range on HMM: 12-299/306.0
NIRKLCAQRNQNQGAGFVTDFQALASIGVGNP--STASKAPENIVKNRYVNITAYDASRVVLKDHD---TDYINASWCP--SYTSPRGFIATQGPVPSSF
....|  .... . |||  .|..|    . .    . .. |||  |||| ||  .| .||.||...   .|||||.     . .| . .||||| ...  
rvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettv

DDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNAEVQYGKVKVKFTRSAMHAHHIERHFEVG-LASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEF
 ||| |.|  .   |||.|.|.| .  || ||||. ... .|||..|. ...  .|. | |.. |    ... .|.|.|. |.||||||||     .|.|
sdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdf

RAEVLKFHERDT---KAPICIHCSAGVGRTGTYIAIDTALQQVQER---AEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNN
  .| . .|. .   . ||..|||||.|||||.| ||. |......   |...|  .. ..|..|. .||| .|| .|.|..   ...
ledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_PTPN9_pd Subfamily PTPN9 16-285 1.3e-67 222.9 In-house 2-288 (297) alignment 
Range on Protein: 16-285
Range on HMM: 2-288/297.0
NIRKLCAQRNQNQGAGFVTDFQALASIGVGNPSTASKAPENIVKNRYVNITAYDASRVVLK----DHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDF
.|..| |  ....  | . ..... .  |    .||| . |. |||| ..  || .||||.    |. .|||||...  |  ...|||||||..  ..||
eieelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WWMIWSYKVGEIVMVTRELETNVLKCHRYWP-EDNAEVQYGKVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAE
| |.|  .|  |||.|| .|.  ||| .||| |...  ..|...|.     .. .. .| .|.  .  . .| |.   | ||||.||| .. ..|... .
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlek

VLKFH--------E----RDTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLD
| .          .    . .. || .|||||.|||||.|..| .|....| . |..   . .||. | |..||  ||.. .. ||.
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 16-289 8.3e-65 213.6 In-house 6-280 (287) alignment 
Range on Protein: 16-289
Range on HMM: 6-280/287.0
NIRKLCAQRNQNQGAGFVTDFQALASIGVG-NPSTASKAPENIVKNRYVNITAYDASRVVLKDHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWM
.. .. |. ...   || . |. | ...   .  | . |..|  |||. .|  .|  ||.||... |||||..  .| . . ||....|. .   .|| .
kfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkl

IWSYKVGEIVMVTRELETNVLKCHRYWPEDNAeVQYGKVKVKFTRSAMHAHHIERHFEVGLAS-GGPTRDVVQLAFQSWPDHG-VPLTSVEFLEFRaEVL
|.  .|  |||...| |..  .|..||||... | .|. .....   ..|. |||..||   .  |... |.|  . .|...| |.     .| .  |  
iddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvie.emy

KFHERDTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNN
| . . ....| .|||..|||.....|..|.......   ...  .. . |. .  .||||.|| .. ..||  |. 
ktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 17-292 2.5e-131 431.9 In-house 2-281 (281) alignment 
Range on Protein: 17-292
Range on HMM: 2-281/281.0
IRKLCAQRNQNQGAGFVTDFQALASIGVGNPSTASKAPENIVKNRYVNITAYDASRVVL----KDHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFW
.|| ..|..||. |||......||.|||.|..|||||.||..||||.||.||||.||..    ....||||||...|.|......||||||||.|...||
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW

WMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNAEVQYGKVKVKFTRSAMHAHHIERHFEVgLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVL
.|.|..|| .|||||||.|.. ||||||||.||.|..||.|.||.|.....|..|||.|..  ...|.||.|.|||...||||||| |. |.||||.|||
qmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevl

KFHERDTKAPICIHCSAGVGRTGTYIAIDTALQQV-QERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNNWLK
|..|..||||..|||||||||||||||.|.....| .|..|....|.. .||..||.|||||.||..|.|.|||||...||
kltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldkelk
subfamily_PTPRB_pd Subfamily PTPRB 17-289 2.1e-89 294.5 In-house 12-287 (293) alignment 
Range on Protein: 17-289
Range on HMM: 12-287/293.0
IRKLCAQRNQNQGAGFVTDFQALASIGVGNPSTASKAPENIVKNRYVNITAYDASRVVL----KDHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFW
. .  .. .... ..|. ... | ..|  .  .|.....|  |||| || .||.||| |    .....|||||.. | |.||| |||||||.|...||||
feehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfW

WMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNAEVQYGKVKVKFTRSAMHAHHIERHFEVGLasGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVL
 |.|  |.  |||.|. .|    ||..|||.|. .|.||..||... .    ... |....    .  .|.| |. |.|||||||| ..  .|.|  .| 
rmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvr

KFH-ERDTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNN
. . .  .|.|| .|||||||||||.||.|. ||...|.  |.| .|. .||..||..|||..|| ..|..||| |..
eaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_Ptp69D_pd Subfamily Ptp69D 18-288 1.8e-71 235.8 In-house 10-287 (307) alignment 
Range on Protein: 18-288
Range on HMM: 10-287/307.0
RKLCAQRNQNQGAGFVTDFQALASIGVGNPSTASKAPENIVKNRYVNITAYDASRVVLK----DHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWW
..   .|...   |.. ... | .  .   ...|.  || .|||| .|.|.|  ||.||    ..|.||||||.  .|   . ||| |.|| .  .||| 
eealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWR

MIWSYKVGEIVMVTRELETNVLKCHRYWPEDnAEVQYGKVKVKFTRSAMHAHHIERHFEVGLAS--G---GPTRDVVQLAFQSWPDHGVPLTSVEFLEFR
||.  .|  |||.. . |.|  ||..|||..  |||||.. ||. ..  | ..|.|...|      .     .| |||  ...|.|  || ..   |.. 
miaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllkli

AEVLKfHERDTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALN
 .| . ...  ..|| .||||||||.|...|.|  |||...  .|.| ... .||..||..||  .|| .... .||  .
eqvre.lyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_CG7180_pd Subfamily CG7180 18-286 1e-50 167.0 In-house 6-289 (296) alignment 
Range on Protein: 18-286
Range on HMM: 6-289/296.0
RKLCAQRNQNQgAGFVTDFQALASIGVGNPSTASKApENIVKNRYVNITAYDASRVVLK----DHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWW
.||. .|.. . . .   ..  . .  |.  .. .. ||. |||.|..  ||  ||||.    ....|||||..  |.. .. .| |..|. .. |.|| 
lklvdkrrkfr.veyklelkltprleigdCagglrk.enreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWr

MIWSYKVGEIVMVTRELETNVlKCHRYWPEDNaEVQYGKVKVKFTRSAMHAHHIERHFEVGLA----------SGGPTRDVVQLAFQSWPD-HGVPLTSV
...  ..  .|..|.. . .  ... |||..  . |||.. |. ...   |.   | | .                .|| | .. .. |.  . ||| . 
lvydeeisavvvLtktfdfak.mypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstn

EFLEFRAEVLKFHERD----TKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDA
 ..|.|  | .. |.     ...|.....| |..|.| |.||| .|..|..  ||..   . .||..|. .|..| .| |.  |.|.|
alielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 19-287 9.8e-80 262.7 In-house 10-279 (288) alignment 
Range on Protein: 19-287
Range on HMM: 10-279/288.0
KLCAQRNQNQGAGFVTDFQALASIGVGNPSTASKAPENIVKNRYVNITAYDASRVVLKD----HDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWM
.  |. .... .||. ....||...  . .||.. ..|  |||| || .||  || ||.    ...||||||.  .. . . .||||||.... .||| .
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

IWSYKVGEIVMVTRELETNVLKCHRYWPEDNAEVQYGKVKVKFTRSAMHAHHIERHFEVGlaSGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKF
.. .|.  |||.|  .| .  ||..|||... ...||.|.|. . |    ....|.....    .  ... |.....|||||||  . ..||..  |   
vyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkva

HERDtKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDAL
.. |   || .|||||||||||.||.|.....|.|   ... ... .||..|...|||. || ....|.|.  
nqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 20-286 8.2e-68 223.6 In-house 14-278 (315) alignment 
Range on Protein: 20-286
Range on HMM: 14-278/315.0
LCAQRNQNQGAGFVTDFQALASiGVGNPSTASKAPENIVKNRYVNITAYDASRVVL----KDHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMI
  ||.. .   ||  |....   |   |   .|  ||  ||||.|| ||| ||| |    .| ..||.||.. . |. .| .||.||| ..| .||| ..
yvaqkkastkngfkqdyesipg.gqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlv

WSYKVGEIVMVTRELETNVLKCHRYWPEDnaEVQYGKVKVKFTRSAMHAHHIERHFevGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFH
. ...|.|||.|   | .  |. .|||..  .| |||. |      .. .   | .     .|   |.|||| . |||| |||  .. ....   | ..|
feedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhh

ERDTkAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDA
. .  ..| .|||||||||||.|..|. |.|..    ...  .| ..|| |  |||...|| ......|..
tnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
0036941 (Phosphotyrosine protein) phosphatases II 21-290 2.3e-84 278.5 In-house 4-280 (297) alignment 
Range on Protein: 21-290
Range on HMM: 4-280/297.0
CAQRNQNQGAGFVTDFQALASIGVGNPSTASKAPENIVKNRYVNITAYDASRVVLKDHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKV
.  ..... |.. . |. | .. .  . .... |||. |||| .| .|| .||.|.| ..||||||. . |  .| ||||||| |....|||.|.| ..|
kllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

GEIVMVTRELETNVLKCHRYWPED-NAEVQYGKVKVKFTRSAM--HAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHER
  |||.|.. | .  ||..|||.. . ...||...|....     ... . |..||    .|..| | .. . .||||||| .  ..|.|  .|.|... 
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

D-TKAPICIHCSAGVGRTGTYIAIDTALQQVQ---ERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNNW
   . |...||||||||.||.||.|..|||..   .. .|.|  .. .||..|...|||. || ... ..|. |.. 
lpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
subfamily_PTPRG_pd Subfamily PTPRG 21-289 1.1e-68 226.8 In-house 10-289 (563) alignment 
Range on Protein: 21-289
Range on HMM: 10-289/563.0
CAQRNQNQGAGFVTDFQALASIGVGN--PSTASKAPENIVKNRYVNITAYDASRVVLKD-----HDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWW
 |.   ..  ||  .|.|| |  . .  . ..|..|||  ||||.||.||| ||| |..     .. |||||..   |   . |||||||... ||||| 
vaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWr

MIWSYKVGEIVMVTRELETNVLKCHRYWPEDNAEvQYGKVKVKFTRSAMHAHHIERHFEVGL-----ASG-GPTRDVVQLAFQSWPDHGVPLTSVEFLEF
|||  .|  |||.|   | .  ||..|||.|..| .||...|. ... ..|   .|.. .        .     . | |  . .|||||||  |.  | |
miWeqnvaiivmitnlvergrrkcdvYWPkdese.tygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLif

RAEVlKFHERDTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNN
     .  ....  || .|||||||||||||..|| |.|.|..  ||.  .. ..| .|||.|||  || ..|...|.|.. 
vkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_PTPRA_pd Subfamily PTPRA 21-286 1.1e-65 216.8 In-house 23-294 (330) alignment 
Range on Protein: 21-286
Range on HMM: 23-294/330.0
CAQRNQNQGAGFVTDFQALASIGVGNPSTASKAPENIVKNRYVNITAYDASRVVLKD----HDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIW
  .|  ..   |  .|.|| .  . .   ...  ||  |||.|||  || |||.|      ...||||||.   |     |||.|||   . .||| |||
irirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiw

SYKVGEIVMVTRELETNVLKCHRYWPEDnAEVQYGKVKVKFTRSAMHAHHIERHFEVG-LA---SGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVL
 .|   |||.|   | .  ||..|||..   | ||...|.   . .  .   |.| |  |.      ..| | |. |.|||| ||| ...  |.. ..| 
eqksativmltelkerkeekcaqywPde.GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvk

KFHERDTKaPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDA
| ... .  || .|||||||||||.|..|. |..|.    |..  .. .||. |  ||||  || ...||.|. 
klnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 21-289 9.7e-65 213.3 In-house 11-285 (290) alignment 
Range on Protein: 21-289
Range on HMM: 11-285/290.0
CAQRNQNQGAGFVTDFQALASIGVGNPSTASKAPENIVKNRYVNITAYDASRVVLK---DH-D--TDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWM
 |. ....  || ..|..| |    .  |   ...|  .||. ||  ||  |..|.   .| |   .||||..   |   . .|||||||..   ||| .
vanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkl

IWSYKVGEIVMVTRELETNVLKCHRYWPEDNAEVqYGKVKVKFTRSAMHAHHIERHFEVGLASG-GPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLK
||  ||  |||.| . | .  ||. |||. ...  ||....| .   .. . |||..||   .  |... |.|. ...|...|        |   .|. |
iwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk

FHERDTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNN
 . .... .| .|||..|||.....|..|......    ... ... ..|. .  .|||| || .....|| .|..
tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
0050432 (Phosphotyrosine protein) phosphatases II 23-293 8.4e-89 293.2 In-house 35-305 (308) alignment 
Range on Protein: 23-293
Range on HMM: 35-305/308.0
QRNQNQGAGFVTDFQALASIGVGNPSTASKAPENIVKNRYVNITAYDASRVVLkDHDTDYINASWCPSY--TSPRGFIATQGPVPSSFDDFWWMIWSYKV
  ....  .. . |..| |. . .. .... |||. ||||..| .|| |||.| |...||||||. . |   .|| ||||||| |....|||.|.| ..|
lekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnv

GEIVMVTRELETNVLKCHRYWPED--NAEVQYGKVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHerd
  |||.|.. | .. ||..|||..  .  ..|||..|....  ...... |..|.   ..|..| | .. . .|||||||    ..|.|  .| |..   
rvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...

TKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNNWLKK
 . ||..|||||||||||.||.|..|.|...  .|..  .. .||..|..||||. || ......|. |...|.|
pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk
subfamily_PTPRK_pd Subfamily PTPRK 23-286 2.5e-66 218.6 In-house 15-276 (314) alignment 
Range on Protein: 23-286
Range on HMM: 15-276/314.0
QRNQNQGAGFVTDFQALASIgvgnpSTASKAPENIVKNRYVNITAYDASRVVLKDHD----TDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSY
. ....| ||  ....|          |.|  ||  |||. .| ||| |||.|.  |    .|||||..  ||. |. ||.||||...   ||| ... .
llkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvyde

KVGEIVMVTRELETNVLKCHRYWPEDNAEvqYGKVKVKFTRSAMHAHHIERHFEVGL--ASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHE
.   |||.|   |.  .|| .|||||     ||..||.. .. ..|  . | | |     .   .| | |. | .||||.||     .|.. ..| | .|
ncasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqe

RdTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDA
  .. .| .||||| |||||.||||. |. ....  |..  .. .||...  ||.|  || ... |.|.|
e.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 23-286 3.6e-62 205.5 In-house 27-290 (319) alignment 
Range on Protein: 23-286
Range on HMM: 27-290/319.0
QRNQNQGAGFVTDFQALASIGVG-NPSTASKAPENIVKNRYVNITAYDASRVVLKDHD----TDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWS
.  ...   .  .|.... .||     | .  ..|  |||..|| |.| ..| |.  .    .||||||.   | ..  .||.||| . . .||| ||| 
sdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiwe

YKVGEIVMVTreletnVLKCHRYWPEDnAEVQYGKVKVKFTRSAMHAHHIERHFEVGL-ASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHE
|..  ||..|        || .||| . ....... ||| .     | .. |..|.   .     |.. |  |. |||.|||  ..... .   | ....
yncstivllt......kdkcsqywplk.ivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhlts

R-DTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDA
. . .|.| .||||||||||.||..|. |....|   |..  .. .||| || .|| ..|| ...  .|. 
kenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 23-287 7.4e-62 204.3 In-house 17-288 (325) alignment 
Range on Protein: 23-287
Range on HMM: 17-288/325.0
QRNQNQgAGFVTDFQALASIGvGNPSTASKAPENIVKNRYVNITAYDASRVVLK----DHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSY
.. |.|  ||  .|. | | . |   ...  |||. |||. |. |.| |||||.    | ..||||||.  ..     |.|.| | ... .|.| ..  .
kkaqdq.dgfahefgllpsdd.giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldW

KvGEIVMVTRELETNVLKCHRYWPED-NAEVQYGKVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHER
.   .|.|. ||...  .|  |||..    ...| ..||.      . .. | ..|  ...| || | |. .|||.| ||.     .. .   | . .||
r.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavser

DTK-----APICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDAL
 |      .|| .||||||||||..|.. .||..| | ..|.|   . .||..|  ||.|| ||  ... . .|.
vtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 23-299 7.2e-41 134.9 In-house 15-294 (305) alignment 
Range on Protein: 23-299
Range on HMM: 15-294/305.0
QRNQNQGAGFVTDFQALASIGVGNPSTASKAPENIVKNRYVNITAYDASRVVLKD-HDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVG
.  ... ||. ..|.|.  .   .   | |  ..  |||| ..   |  || |.     .|| | .  . | |. || || |.  .  |||.| .  || 
rtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkve

EIVMVTRELETNVLKCHRYWPEDNAEV-Q----YGKVKVKFTRSAMHAHHIERHFEVG------LASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAe
 | |.   ||    ||. |.. .. .| .      |. |||  |.    . . . .|         .|. .| | .  .  ||| ||| . .  ||. . 
aifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelle.

vlkfHERDTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEV-NIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLdalnNWLKKhKDIID
    . | .| || .|||||.||||. . ..  |.|. .   . . | |. ..|. ||  .|| ||| .||.|.|    |...| |...|
....karpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvil....nyfrk.kklld
0047943 (Phosphotyrosine protein) phosphatases II 24-286 2.3e-84 278.4 In-house 6-271 (273) alignment 
Range on Protein: 24-286
Range on HMM: 6-271/273.0
RNQNQGAGFVTDFQALASIGVGNPSTASKAPENIVKNRYVNITAYDASRVVLKDHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEI
..... ...   |..| |. .  . .... |||. |||| .| .|| |||.|.| ..||||||. . | ..| ||||||| |....|||.|.| ..|  |
ekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

VMVTRELETNVLKCHRYWPEDNA--EVQYGKVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHERD-TK
||.|.. | .  ||..|||...   ...|||..|....   ..... |..|.   . | .| | .. . .||||||| .  ..|||  .| |..| .  .
VmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn

APICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDA
 |...|||||||||||.||.|..|.|.... .|... .. .||..|  ||||. || ......|. 
gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 24-287 2e-69 229.0 In-house 16-283 (305) alignment 
Range on Protein: 24-287
Range on HMM: 16-283/305.0
RNQNQGAGFVTDFQALASIgvGNPSTASKAPENIVKNRYVNITAYDASRVVLKDH----DTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYK
 . ..  |. .....|..   ...    |  .|  |||...|| .| .|. |. .    |.||||||.  .| .   .|..|||...  .||| .|. .|
arvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveek

VGEIVMVTRELETNVLKCHRYWPEDNAE-VQYGKVKVKFTRSAMHAHHIERHFEVGL-ASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHER
| .|||.|.  | .  ||..||||  .| ...|...|. . ..  . .|||....    .   .| |.|. . .||||||| ..  .|..  .| | ...
vstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk

DTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDAL
| . |. .||||||||||..||.| ||.....  .|..  .. |||..|  |||| .|| ..| .. . .
dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 24-288 1.4e-50 167.1 In-house 14-280 (439) alignment 
Range on Protein: 24-288
Range on HMM: 14-280/439.0
RNQNQGAGFVTDFQALASIGVGNPSTASKAPE--NIVKNRYVNITAYDASRVVLKD----HDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWS
 ..|.   |   |. . |.       || | .  .  |||| ...|.| .||.|..      . |||| .   |  .. .||||||   . |||| ... 
ldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlvie

YKVGEIVMVTreletNVLKCHRYWPEDnAEVQYGKVKVKFTRSAMHAHHIERHFEVGL--ASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFH
 |. .|||.|     |... ..||| | ||| || . |.  |     ... | | |     ..   | |.|. . .|||. ||  .   |.|   .    
kktvtivmlt.....nlvesykywpsd.aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsan

ERDTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALN
...   |. .||||||||||| ||.| ||.|..   .|.|. |.  ||..|. |||...|| .... ||. . 
dkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavlediv
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 24-296 4.7e-44 145.6 In-house 9-283 (307) alignment 
Range on Protein: 24-296
Range on HMM: 9-283/307.0
RNQNQGAG-FVTDFQALASIGVgNPSTASKAPENIVKNRYVNITAYDASRVVLKDH--DTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKV
|  ..|   .| .|. ||     .  |.     |  |||| .. . | .|.|.| .   .||| | .    . |. ||..|||  ..  .|| |.   ||
rtldkgvqalvdefrvlakktp.egvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekv

GEIVMVTRELETNVLKCHRYWPEDN-AEVQYGKVKVKFTRSAMHAHHIER---H---FEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFraevLK
  ..|. . .|.  .||..||| ..  .  .|.     . . . |...          .. .  .. .| . .| .. |||.||| . .  ...    |.
esvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainl....le

FHeRDTKAPICIHCSAGVGRTGTYIAIDTALQQ-VQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDalnNWLKKHKD
   |  . |. .||||||||.|| .||    .. ..     ... .. .||..|.. .|| ||| |.|.|.|.    .|...|.
av.rydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle...yflelyke
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 25-288 1.9e-64 212.6 In-house 12-277 (515) alignment 
Range on Protein: 25-288
Range on HMM: 12-277/515.0
NQNQG-AGFVTDFQALASIGVgNPSTASKAPENIVKNRYVNITAYDASRVVL----KDHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYK
|.|.  . |  .|. |    .  | | ..   |  |||| ||  || .|| |     . . ||.|||  ||. . . .||.||| ..| |||| ... ..
nknrhttlfseefhdlpgpni.ypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqen

VGEIVMVTRELETNVLKCHRYWPE-DNAEVQYGKVKVKFTRSAMHAHHIERHFEVglASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHERD
|  |.|||.  | .  || .|||.     |..|..||.       .  | |...|    |  .| | |  |. |||.|||  .  .| .  ||   |.. 
vttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqy

TkAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALN
|  |. ||||||||||| .|.||  . ....   |..  .. ..||.| ..|||  |||... .||. | 
t.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 26-287 5.6e-49 161.6 In-house 16-236 (392) alignment 
Range on Protein: 26-287
Range on HMM: 16-236/392.0
QNQGAGFVTDFQALASIGVgNPSTASKAPENIVKNRYVNITAYDASRVVL----KDHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVG
. . | |. .|. | .  .  | |... . |. |||| ||  ||..||.|       |.||.|||. ||. . . .||.||| ..|.|||| |..  .| 
nrhsalffeefhdlpgpdi.ypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvt

EIVMVTRELETNvlkchrywpednaevqygkvkvkftrsamhahhierhfevglaSGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHERDTkA
 |.|||.  | .                                            |  .| | |  |  |||..||  .  .|.|  ||   . . |  
tiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyt.h

PICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDAL
|. |||||||||||  |.||. . . ..   |..  .. ..|..| .||||  |||...  ||. |
pliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 27-304 1.8e-78 258.8 In-house 17-299 (318) alignment 
Range on Protein: 27-304
Range on HMM: 17-299/318.0
NQGAGFVTDFQALASIGVGNPSTASKAPENIVKNRYVNITAYDASRVVLKD----HDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGE
.    . .....|.       |. |  | |  ||||.||.||| .|| |..    ...|||||.. . |.. . .||.|.|.|  ..||| |.|  .   
sGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsav

IVMVTRELETNVLKCHRYWPEDNAeVQYGKVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHERDTKAP
|||.|.| |    |.|||||....  .|||..|. . .   .... |.|.|       .|.| |  . ||||.|||  ....|..  .| | ... .. |
ivmltqeeergkakvhryWPskgs.rsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagp

ICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNNWLKK--HKDIIDRERER
| .||||||||||..||.|. |..... | |..  .. |||..|| ||||  || ....|.|.||.   ..   .|. .| || 
ivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirel
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 27-102 4.4e-13 43.2 In-house 20-95 (95) alignment 
Range on Protein: 27-102
Range on HMM: 20-95/95.0
NQGAGFVTDFQALaSIGVGNPSTASKAPENIVKNRYVNITAYDASRVVLK-DHDTDYINASWCPSYTSPRGFIATQG
|    |  .|... |.  | | |.  .  || |||..||  |||.||||    |.||||| .   |.    .||.||
nsdqefdnefksi.smtsgapytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaqg
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 28-287 7.7e-48 157.7 In-house 13-293 (301) alignment 
Range on Protein: 28-287
Range on HMM: 13-293/301.0
QGAGFVTDFQALASiGVGNPSTASKAPENIVKNRYVNITAYDASRVVLKDH------DTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVG
.  .|  ....| . |  ...| .   || . ||. ||| ||  |..|| .       ..|||||.  .|.. . |||.|||. .   ||| .|| .|. 
hsnkfeeqykelke.gedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

EIVMVTRELETNVLKCHRYWPE-DNAEVQYGKVKVKFTRSAMHAHHIERHFEVGLASGGP---------------TRDVVQLAFQSWPDHGVPLTSVEFL
.||||| . |.   ||..|||. .. . ..|...|... ....  .. |.. | .  |                 ..||.||   .||..||       |
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvL

EFRAEVLKFHERDTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDAL
.   .|..   .  ..|. .|||..|.|.|.|.... .| |..    |..  ..  .|. .  .|.|  ||  ...|.   |
qviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 29-289 8.3e-65 213.7 In-house 18-281 (315) alignment 
Range on Protein: 29-289
Range on HMM: 18-281/315.0
GAGFVTDFQALASIGVgNPSTASKAPENIVKNRYVNITAYDASRVVL----KDHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIV
 | |  .|. |    .  . .... ..|  |||| ||  .| .||.|    .. | ||||||  .|. . . .||.||| ..| |||| |.. .||  ||
talfseefhdlpdPdi.yrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttiv

MVTRELETNVLKCHRYWPE-DNAEVQYGKVKVKFTRSAMHAHHIERHFevGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFhERDTKAPI
|||   | . .|| .|||. .   |..|..||.       .  . |..  ..  .  .| | |  |. |||.||.  .  .|..  ||    ..  . ..
mvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsl

CIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALN--N
 .||||||||||  |.||  ..|....  |..  .. .||..| ..|||  .||... .||. |   |
lvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrn
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 30-88 4e-09 30.3 In-house 22-83 (440) alignment 
Range on Protein: 30-88
Range on HMM: 22-83/440.0
AGFVTDFqALASIGVGNPSTASKAPENIVKNRYVNITAYDASRVVLKD----HDTDYINASWC
  |  .. .|   |. .||  .  |.| ||||| || ||| |||.|..     |.||||||. 
rafedew.sllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyi
0046845 (Phosphotyrosine protein) phosphatases II 32-293 8e-86 283.2 In-house 2-280 (284) alignment 
Range on Protein: 32-293
Range on HMM: 2-280/284.0
FVTDFQALASIGVGN--PSTASKAPENIVKNRYVNITAYDASRVVLKD-----HDTDYINASWCPSY-----TSPRGFIATQGPVPSSFDDFWWMIWSYK
.  .|..| |. |    . .....|||. ||||..| .|| |||.||      .|.||||||. . |      ... |||||||.|....|||.|.| ..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VGEIVMVTRELETNVLKCHRYWPEDNAEVQYGKVKVKFTRSAMHAHHIERHFEVGLAS-GGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHER-
|  |||.|.. | .. ||..|||...  ..||...|....  .. ... |..|.   . .|..| | .. . |||||||| ..  .|||  .| ...|. 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

DTKAPICIHCSAGVGRTGTYIAIDTALQQVQERA---EVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNNWLKK
... ||..|||||||||||.||.|..|.|....    .|..  .. .||..|..||||..|| .|....|..|...|..
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 32-285 5e-46 151.9 In-house 8-264 (283) alignment 
Range on Protein: 32-285
Range on HMM: 8-264/283.0
FVTDFQALASIGVGN-PSTASKAPENIVKNRYVNITAYDASRVVLKDHDTDYINASWCP---SYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVT
.   .. |  ..| . ... . | ||  |||. .| ..|  || || .  |||||.. |   ||   ...|..|.|.     ||| |..  |.  |||.|
nklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmlt

RELETNVLKCHRYWPEDNAeVQYGKVKVKFTRSAMHAHHIERHFEVGLA-SGGPTRDVVQLAFQSWPDHGvPLTSVEFL-EFrAEVLKFHERDTKAPICI
.  | .  || .|||.. . ..||.  |   .   .   | . . .    |   |  .    .. | . | . . .. |  |   |     .  |.|| .
klqedlrikCsqyWPkrGs.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkf.nkvislqteskkgPivv

HCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLD
|||.|.|||...||. .......  . |.. |..  .|..|  .|||  ||  ||..||.
hCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
DSPc_SM00195 33-287 6e-79 260.4 In-house 3-262 (263) alignment 
Range on Protein: 33-287
Range on HMM: 3-262/263.0
VTDFQALASIGVGNPSTASKAPENIVKNRYVNITAYDASRVVLKDHD----TDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTR
 ..|. | .    ...| .. ..|  |||| ||  || .|| ||. .    .|||||..   ..... .|||||| || ..|||.|.|  ||  |||.|.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

ELETNVLKCHRYWPED-NAEVQYGKVKVKFTRSAMHA-HHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHERDtKAPICIH
| | .  ||.|||||. . . ..||..||...   .  . | |..|.       ||.| |. ...||||||| .  ..||.  .| | ...  ..||..|
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVh

CSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDAL
||||||||||...||..|....|  .|.|..|. .||..|  |||| .||.......|...
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 33-287 6e-79 260.4 In-house 3-262 (263) alignment 
Range on Protein: 33-287
Range on HMM: 3-262/263.0
VTDFQALASIGVGNPSTASKAPENIVKNRYVNITAYDASRVVLKDHD----TDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTR
 ..|. | .    ...| .. ..|  |||| ||  || .|| ||. .    .|||||..   ..... .|||||| || ..|||.|.|  ||  |||.|.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

ELETNVLKCHRYWPED-NAEVQYGKVKVKFTRSAMHA-HHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHERDtKAPICIH
| | .  ||.|||||. . . ..||..||...   .  . | |..|.       ||.| |. ...||||||| .  ..||.  .| | ...  ..||..|
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVh

CSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDAL
||||||||||...||..|....|  .|.|..|. .||..|  |||| .||.......|...
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN3_pd Subfamily PTPN3 33-287 1.4e-71 235.7 In-house 18-275 (280) alignment 
Range on Protein: 33-287
Range on HMM: 18-275/280.0
VTDFQALASIGVGNPSTASKAPENIVKNRYVNITAYDASRVVLKDHDTDYINASWC----PSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTR
.. |. |     |   .|.. |||..|||| .|..||| || ||. .||||||..     || .    .||||||....  ||| |.|  |.  |||.| 
laqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmltt

ELETNVLKCHRYWPEDNAEVQYGKVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHErDTKAPICIHCS
 .|    |||.|||| . |..||. .|| .... .  .. |.. .  ..    | ..|| . .|||||||  | .||||  .| | ..  .. |. .|||
lverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrs.gkeePvvvhCs

AGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDAL
||.|||| .|...|||. .... .|.. .|. ..|. |  .|||..|| .| . .| . 
aGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 33-293 2.1e-34 113.8 In-house 9-265 (267) alignment 
Range on Protein: 33-293
Range on HMM: 9-265/267.0
VTDFQALASIGVGNPS-TASKAPENIVKNRYVNITAYDASRVVLKDHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELE
  .|. .  |   .   . | | .|  .||. .   || .||.|.... .|||||.  .|   . ||.||.|.  .  ||. .|  .||  ||..|.  .
ekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvft

TNVLKchrYWPED-NAEVQYGKVKVKFTRSAMHAHHIERHFEVGLASGgPTRDVVQLAFQSWPdhgVPLTSVEFLEFRAEVL-KFHERDTKAPICIHCSA
 |. .   .||       .|  . |...       .    .|. .     ...|.   .. |    .      .|.    .| | .  .   |. ..||.
dnirl...fwPPkmgqakkyqdltvehslekeendyqiitlelkfkne.sahnvtlyyykkwn...intnnkpylkplfgilaknqlengnrPlvvacsd

GVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNNWLKK
||||.||.. ||. |.....   ..|   . ..|. |  .|.|  .| |.|... .  .  ||.
GvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaegrlke
subfamily_PTPN14_pd Subfamily PTPN14 34-289 4.7e-56 185.0 In-house 27-298 (300) alignment 
Range on Protein: 34-289
Range on HMM: 27-298/300.0
TDFQALASIGVGNPSTASKAPENIVKNRYVNITAYDASRVVL---KDHDTDYINASWCPS--YTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTR
|... ..        ...| |||  |||. ..  |. .|| |   |. .|.|||||       .. | .|..|||..    ||| |.|  .|  |||.|.
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlte

ELETNVLKCHRYWPED---NAEVQYGKVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVL--KFHE------R
| |    |...|.|..   . .|..|| ||    |      | . ...     .  |.|. | .. |||||||    .||..  ||   . .       .
eeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsevesk

DTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNN
..| |. .||||||||||  |  |  .. ..   |..|. ....||. | ..|||.||| .|.||..  |.|
eskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 34-291 6.7e-19 62.6 In-house 26-284 (303) alignment 
Range on Protein: 34-291
Range on HMM: 26-284/303.0
TDFQALASIgVGNPSTASKAPENIVKNRYVNITAYDASRVVLKdhDTDYINASWCPSYTSPRGfIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETN
 .|. ..|  .    .  .  .|. |||.|..   | |.| |   |. || ||.    .| .  | || |.. .  ||| ||   ||  ....  . | .
nefekvvsy.lppsvsknqfvknmdknrfvdvicldhskvkls..dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseyd

VLKCHRYWPEDNAEVQYGKVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQL-AFQSWPDHGVPLT-SVEFLEFRAEVLKFHERDTKA-PICIHCSAG
 |  .  .|...  ... .  ..              . |   | |  .  ...  ...||   .|   | .|.    ..  .  . ... |      .|
klggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsg

VGRTGTYIAIDTAL-QQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDA-LNNWL
.||.||.  ..||     .|.| ...   . ..|. |   || ..|...|. .. .  |.| .
cgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngi
0045098 (Phosphotyrosine protein) phosphatases II 35-290 6.5e-74 244.1 In-house 12-275 (278) alignment 
Range on Protein: 35-290
Range on HMM: 12-275/278.0
DFQALASIGVGNPSTASKAPENIVKNRYVNITAYDASRVVlkdhdtDYINASWCPSYtsPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNV
.|. | . |  .  | .  ..|. ||||..| .|| |||.      ||||||. ..|  |. ||||||| || ..||| |.|....  |||.|...| ..
efefllllgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgr

LKCHRYWPEdNAEVQYGKVKVKFTRSAMHAHHIERHFEVGLA----SGGPTRDVVQLAFQSWPDHGVPLTS--VEFLEFRAEVLKFHE------------
 ||..|||| .  ..||...|...   .. . . |...|       .....| | .| . .||||||| ..    |||.  .......            
ekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslll

RDTKAPICIHCSAGVGRTGTYIAIDTALQQVqErAEVNIDAIIGQLRQHRNF-MVQTVAQYAYVHKVVLDALNNW
 | . |. .|||||||||||..|... |... |   |... .. .||..|.. .||.  || ......|. |...
ldsggpvlVHCsaGvgRtGtlvaaylmlell.e.ggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_PTPN13_pd Subfamily PTPN13 35-288 2.6e-65 215.4 In-house 16-270 (273) alignment 
Range on Protein: 35-288
Range on HMM: 16-270/273.0
DFQALASIGVGNPSTASKAPENIVKNRYVNITAYDASRVVLKDHDTdYINASWCPSYT--SPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELET
.|. |  .   . .. .|  ||  |||| |.  ||..|| |.|. . |||||.           .||.|||.| . .||| |.|  |.  |.||| | |.
efkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekek

NVLKCHRYWPEDNAE-V-QYGKVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHErdTKAPICIHCSAG
. .|||||||| . . .  .....|.  .   .     |...|     | .|.|..| | .||||||| ...|.|.| ||| ....   ..|| .|||||
gkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaG

VGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALN
.||.||.|.||..|. ..   |...  |. .||. |. .|||  || .|.|..|..|.
iGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 35-297 1.2e-60 200.4 In-house 3-262 (284) alignment 
Range on Protein: 35-297
Range on HMM: 3-262/284.0
DFQALASIGV-GNPSTASKAPENIVKNRYVNITAYDASRVVLKDHD----TDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTre
.|.... .|| |   | .  ..|  |||...| |.| ..| |.  .    .||||||.   | ..  .|||||| . . .||| ||| |..  ||..|  
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..

letnVLKCHRYWPEDnAEVQYGKVKVKFTRSAMHAHHIERHFEVGL-ASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHER-DTKAPICIHC
      || .||| . ....... ||| .     . .. |..|.   .     |.. |  |. |||.|||  ..... .   | ..... . .|.| .||
....kdkcsqywplk.ivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhc

SAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDalnNWLKKHKDI
||||||||.||..|. |....|   |..  .. .||| || .|| ..|| ...  .|.   . |  | |.
sagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle...ehlfghsdv
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 35-286 2.5e-42 139.5 In-house 16-268 (281) alignment 
Range on Protein: 35-286
Range on HMM: 16-268/281.0
DFQALASIGVGNPSTASKAPENIVKNRYVNITAYDASRVVLKD-----HDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRE
.|  |      .  |. . | |  ||||.|| . | ||| ||        |||| | .  |    ||.| ||||   .  ||| |||  .   |||. . 
efsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqf

LETNVLKCHRYWPEDN-AEVQYGKVKVKFTRSAMHAHHIERHfeVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFraeVLKFheRDTKAPICIHCS
||||  ||  |.| .  . .|. |. |..  |..    .  .  . |.  | || . .  .. |||  || .|  .|.    . |   |   .|  ||||
letnrekcaeyfprnahcclqfdklsvsyedstvnkslvttr..lnlsyegetrlithwlwkewpdwqvpessevmlki...lrki..rarstppvihcs

AGVGRTGTYIAIDTALQQVQERAE-VNIDAIIGQLRQ-HRNFMVQTVAQYAYVHKVVLDA
|||||.|| .|.. ||| .. .    .|  |. .||   |   |||. ||  . ||.|| 
agvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_ptpA1_pd Subfamily ptpA1 41-240 8.4e-34 112.0 In-house 33-249 (418) alignment 
Range on Protein: 41-240
Range on HMM: 33-249/418.0
SIGVGNPSTASKaPENIVKNRYVNITAYDASRVVLKD----HDTDYINASWCPSyTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLK
|.|  . |   |   |  |||| ||   . .|| ||       .||||| .    . |. ||.||||.| .  ||| |.|  ..  |||..|| |   .|
svgpsetsegdk.khntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrik

CHRYWPEDNAEVQ---YGKVKVKFTRSAMHA-HH---IERH---FEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKF-----HERDTKA
| |||||.    |   ||. .  |   ..         ||     .. |.  | |||. |  .. |||| .|  .  | ..   . .         | . 
cdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnv

PICIHCSAGVGRTGTYIAI
|| .|||||||||||. . 
piivhcsagvgrtgtfcta
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 44-129 1.1e-06 22.4 In-house 22-109 (332) alignment 
Range on Protein: 44-129
Range on HMM: 22-109/332.0
VGNPSTASKAPENIVKNRYVNITAYDASRVVLK--DHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRE
.  | |  |  .|.  ||   . ..| ||| |   |   |. ||||   |.    .| .| |.    .  .| . | .   ...|  .
mtypntydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgd
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 46-288 4.5e-61 201.6 In-house 41-285 (297) alignment 
Range on Protein: 46-288
Range on HMM: 41-285/297.0
NPSTASKAPENIVKNRYVNITAYDASRVVLK----DHDTDYINASWCPSYTSprGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVlKCHRYW
 |.| ..   |. |.|| ||  || ||| |.    | | ||.|||. ...     .|.|| | ... .||| |.. ..|  |||.. . |..  || |||
qpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryW

PEdNAEVQYGKVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPL--TSVEFLEFRAEVLKFHERDTKAPICIHCSAGVGRTGTYIA
.. .. ...|.| |. .  .     |.|..||   .   .| | |  | .|||. |.   .   .|..  || | ..  ...|. .||.||||||| ...
sd.kgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvllt

IDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALN
||  . ....  ||.|  .. .|||.| ..|||  ||..|...||.|| 
idsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_PTPN12_pd Subfamily PTPN12 47-295 3.7e-67 221.2 In-house 31-285 (290) alignment 
Range on Protein: 47-295
Range on HMM: 31-285/290.0
PSTASKAPENIVKNRYVNITAYDASRVVLKD----HDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWP
...|....||. |||| .|  || |||.|.     .. |||||..    ...  .||.|||.|   |||| |||...|  .||. ||.| .  ||.||||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

ED-NAEVQYGKVKVKFTRSA-MHAHHIERHFEVGLAsgGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHErDTKAPICIHCSAGVGRTGTYIAI
|  . |...|...|. ..   ..  .. | ..|     . .| | |. ...||||||| .  . ||. ..| ...| . .||...||||||||||| |||
eegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiai

DTALQQVQERA---EVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNNWLKKHK
| . ......    |...  .. .||..|. .|||  || .|.| |.. ... |.  .
dyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiie
subfamily_PTPN1_pd Subfamily PTPN1 47-289 2.8e-56 185.4 In-house 23-273 (290) alignment 
Range on Protein: 47-289
Range on HMM: 23-273/290.0
PSTASKAPENIVKNRYVNITAYDASRVVLKDHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNA
| ...| |||  .||| ... || ||..|...|.||||||        | .| ||||.|.  | || |.|  |   .||. . .| . .||..|||... 
ptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee

--EVQYG--KVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHE-RDTKAPICIHCSAGVGRTGTYIAID
  |...   |.|||. .  .. ... |..|.   .   ||....  . .||| ||| .   ||.|  .| .     . . |  ||||||.||.||.. .|
ekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvd

TALQQVQERAE---VNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNN
| | ..... .   |.|   . .||..|  ..||  |  . .  .|.  . 
tclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv
subfamily_PTPRN_pd Subfamily PTPRN 47-292 2.1e-50 166.1 In-house 45-297 (297) alignment 
Range on Protein: 47-292
Range on HMM: 45-297/297.0
P--STASKAPENIVKNRYVNITAYDASRVVLKDH----DTDYINASWCPSyTSPR--GFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCH
|  ....||..|. |||. .. .|| ||| ||..    ..||||||     . ||   .||||||..|.  ||| |.|   |  ||..||  |..| .|.
pstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaild.hdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqck

RYWPEDNAEVqYGKVKVKFTRSAMHA-HHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHeRDTKAPICIHCSAGVGRTGTY
||||.. .|| |.  .|..    . .  .. | | .       || | |. | |||..||| ..  .||||  | | . |   .|| .|||.|.||||.|
rywpdeGsev.yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksy.rGrscpivvhcsdGaGrtGvy

IAIDTALQQVQER-AEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNNWLK
|.||  |....    |..| | .  ||. |. .|.| .|. .. ..| . .|. ||
ilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevnailk
0040439 (Phosphotyrosine protein) phosphatases II 48-287 2.1e-76 252.1 In-house 3-246 (249) alignment 
Range on Protein: 48-287
Range on HMM: 3-246/249.0
STASKAPENIVKNRYVNITAYDASRVVLKD----HDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPE
 . .. |||. ||||..| .|| |||.|..     ..||||||. . | ..| ||||||| |....|||.|.| .... |||.|.. | .  ||..|||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

dNAEVQYGKVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHERD-TKAPICIHCSAGVGRTGTYIAIDT
 . ...||...|....  .... . |..|.     |..| | .. . .||||||| .  ..|.|  .|.|..|.. .. |...|||||||||||.||...
.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

ALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDAL
.|.|.... .|... .. .||..|. .||.  || ......|. |
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0049772 (Phosphotyrosine protein) phosphatases II 48-292 2.4e-37 124.7 In-house 38-285 (314) alignment 
Range on Protein: 48-292
Range on HMM: 38-285/314.0
STASKAPENIVKNRYVNITAYDaSRVVLKD---HDTDYINASWCPSYtspRGFIATQGPVPSSFDDF----------WWMI--WSYKVGEIVM-------
 .... ..|. |||| .|  .| .||.|.    ...||||||.  ..   . ||||||| .  ..||          | |.  . ..|  |||       
ilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------VTRELETNvlkchrywpednaevQ----------YgkvkvkftrsamhahhierhfEVGLASGGPTRDVVQLAFQSWPDHGVPlTS
               ..  . .                                                |.      ..| ....    .||...| ..
delsrLdaAlgKtpllildgng...............neptaadlellk.....................eelydpelferlgikylripvpDgsap.ll

VEFLEFRAEVLKFherDTKAPICIHCSAGVGRTGTYIAIDTALQQVqeraEVNIDAIIGQLRQHRN-----FMVQTVAQYAYVHKVVLDALNNWLK
  |.|| . ....   |.. |. .||.||.|||||.....  . .      |... .. ..|. |       ....  || ......|..|.. .|
edfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflkk
0037934 (Phosphotyrosine protein) phosphatases II 49-285 6.3e-71 234.0 In-house 3-240 (243) alignment 
Range on Protein: 49-285
Range on HMM: 3-240/243.0
TASKAPENIVKNRYVNITAYDASRVVLKDhdTDYINASWCPSYtsPRgFIATQGPVPSSFDD----FWWMIWSYKVGEIVMVTRELETNVLKCHRYWPed
. .. |||. |||| .| .|| |||.|..  .|||||.... .  || .|||||| |....|    || |.|..... |||.|.. | ...||..|||  
siallpenlsknrysdilpydhsrvkleg..sdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..

nAEVQYGKVKVKFTRSAMHAHHIERHFEVGLAS-GGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHER-------DTKAPICIHCSAGVGRTGT
  ||.||...|... .  ... . |....   . ...|| |... . .||||||| .   .|.|  || .| |.       |.. |...|||||||||||
.gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGt

YIAIDTALQQVqeraEVNIDAIIGQLRQHRNF-MVQTVAQYAYVHKVVLD
.||... |...    .|... .. .||..|.. .|||  || ......| 
liaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 49-211 1.3e-29 98.0 In-house 26-193 (297) alignment 
Range on Protein: 49-211
Range on HMM: 26-193/297.0
TASKAPENIVKNRYVNITAYDASRVVLKDH--DTDYINASWC--PSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPED
...| .  . |||| .| |.| .|| |.    ..||||| .   |   ..  .| .|||. .. |||| ...   |. ||||..  |    ||  |||. 
ssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

NAEV-QYGKVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEV
. |  . |.| |.|  |    ..     |. |     .| |    | ||||||||    .   |.|.|
vqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqv
subfamily_egg_pd Subfamily egg 49-310 3e-23 77.0 In-house 33-292 (307) alignment 
Range on Protein: 49-310
Range on HMM: 33-292/307.0
TASKAPENIVKNRYVNITAYDASRVVLKD----HDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNvlKCHRYWPED
| . . .|  | |   .   | ||| |.     .  |.| |           || .| |.  . |||| |..  .|  |||.|   |..  .|. |||  
ttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkese..rceyywpka

NAE-VQ--YGKVKVKFTRSAMHAHHIERHFEVGLasGGPTRDVVQLafQSWPDHgVPLTSVEFLEFRaeVLKfHERDTKAPICIHCSAGVGRTGTYIAID
... ..   | ....  .   .|  . |  .. |   |. ..   |  . |    |  .|  .  .|  ||. . |.   |. ...  || ...| .||.
esdslvtvpGslrienlkvdskadplfrvtklkl..vGgddeerfl..ehwqgd.vnnssdvysplr..vlr.klrnlskpvvvqdilGvskaatlvaie

TALQQVQER--AEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNNWLKKHKDiIDRERERMAAEQA
.|| ..         .   .  ||..|.. |..| .| .|...||  . . .   |. .| . ||   |..
iallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsake.ldvdyerwleers
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 49-129 3.5e-09 30.6 In-house 30-119 (347) alignment 
Range on Protein: 49-129
Range on HMM: 30-119/347.0
TASKAPENIVKNRYVNITAYDASRVVLKD---------HDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRE
|...   .. |||  .    ||.||||           .   |||||      . . .| || |.|..  ||| |.   || ..| .   
tsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifep
subfamily_eak_pd Subfamily eak 50-208 6.3e-12 39.5 In-house 46-204 (332) alignment 
Range on Protein: 50-208
Range on HMM: 46-204/332.0
ASKAPENIVKNrYVNITAYDASRVVLKDH---DTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDN-
 ..  |.. .|  |.|  ||   | |         |||||        | .| |  .  .    || |.   |   ||..  ..| .. |  .|.|..  
etarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktr

AEVQYGKVKVKFTRSaMHAHHIE-RHFEvgLASGGPTRDVVQLAFQSWPDHGVPLTSvEFLEFR
 |...|...|.     ..   .| | .|  |  |  |  |    .  | .  .|    .|| .|
eelkfGildverkef.vkrniletrlle..lskGnethrvlhykvfGwtettlpkye.dflalr
0042113 (Phosphotyrosine protein) phosphatases II 51-287 2.3e-76 251.7 In-house 4-243 (245) alignment 
Range on Protein: 51-287
Range on HMM: 4-243/245.0
SKAPENIVKNRYVNITAYDASRVVLKDHD----TDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEdNA
.. |||. ||||..| .|| .||.|....    .||||||. . |  ...||||||| |....|||.|.|....  |||.|.| | .  ||..|||. . 
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge

EVQYGKVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHERDTKAPICIHCSAGVGRTGTYIAIDTALQQ
...||...|....   ... . |..||     ...| |... . .||||||| ..  .|.|  .|.|. ..| . |...|||||||||||.||....|.|
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

VQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDAL
.... .|... .. .||..|  .|||  || ......|. |
lekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 51-288 9.3e-71 232.9 In-house 4-243 (250) alignment 
Range on Protein: 51-288
Range on HMM: 4-243/250.0
SKAPENIVKNRYVNITAYDASRVVLK----DHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLkCHRYWPEDNA
.| |.|  |||| .| |.| |||||.    |...||||||.  .|.  . |||||||..... ||| |.. .|.| |||.|   |..   .|.||| ..|
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

EvQYGKVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHERDTKAPICIHCSAGVGRTGTYIAIDTALQQ
| .||.|.|.   . ..|  . |.. .  |.    | |.|| | .||| ||| .    ||.. .| . ...  .||. ..|||||||.|..||||. |..
e.kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

VQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALN
...   |..  .| .||..|  .|.. .|| .|....| ||.
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_PTPN23_pd Subfamily PTPN23 51-294 5.3e-62 204.2 In-house 38-287 (288) alignment 
Range on Protein: 51-294
Range on HMM: 38-287/288.0
SKAPENIVKNRYVNITAYDASRVVLKDHDTDYINASWCPSYT--SPrGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNAE-
. |  .  |||. .|  || .||.|...  ||||||.  . .  .|  |||||.| .|.  ||| |... |.  |||.. . |..  |..||||||. | 
aiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkget

VQYGKVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLK---FHERDTKAPICIHCSAGVGRTGTYIAIDTAL
|..|...|   .     .|.||....   .   ...|. | ..|||..||| .  ..|.|  || .    ..| .|.|. .||||||||||..  . .|.
vkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaav

QQVQERAE-VNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNNWLKKH
......   ..|  .. .||. | ||||...|.  . ..|| | .. |.|.
relekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvldkr
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 51-284 2.1e-52 172.6 In-house 3-238 (239) alignment 
Range on Protein: 51-284
Range on HMM: 3-238/239.0
SKAPENIVKNRYVNITAYDASRVVLK----DHDTDYINASWCPSY-TSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDN
.|   |  |||| || .|| |||||.    |  .||||||.   |  ||. .||||| |  |  ||| |.|  .   |||.|  .|    |||.|||.  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

AevQYGKVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHErDTKAPICIHCSAGVGRTGTYIAIDTALQ
.  .| ...| . .. . | .| | | .        | | |  |  |||.|||  .   | .| .. |        |  |||||||||||... ||. |.
s..kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdsl.pgarpwvihcsagvgrtgaflvidamlr

QVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVL
| ...  |.|   .  .|. | .||||  || ..|  ||
qakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 52-285 3.8e-59 195.0 In-house 24-266 (274) alignment 
Range on Protein: 52-285
Range on HMM: 24-266/274.0
KAPENIVKNRYVNITAYDASRVVL-----KDHDTDYINASWCPSYT-SPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDN
. . .  |||| .|   . |||.|     .|.|..|||| .   |    . ..|||||.|.  .||| ||.  .|  |||.|.  |.|  ||..|.|...
dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

AE---VQYGKVKVKFTRSAMHAHHIERHFEVGLASGgpTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHERDT-K-APICIHCSAGVGRTGTYIAI
      .||.|..|..    . ..  |.. .  ..   .|.|.   . .|||| .|    ..|.. .|| . .|... | ||. .|||||.|||| .|||
dyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai

DTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLD
. |..|..|.  |..  |. .||..|  ||||  || ..|...  
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 52-286 9.3e-53 173.8 In-house 3-239 (239) alignment 
Range on Protein: 52-286
Range on HMM: 3-239/239.0
KAPENIVKNRYVNITAYDASRVVLK----DHDTDYINASWCPSY-TSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNA
|   |  |||| || .|| |||||.    |  .||||||.   |  ||. .||||| |  |  ||| |.|  .   |||.|  .|    |||.|||.  .
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

evQYGKVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHErDTKAPICIHCSAGVGRTGTYIAIDTALQQ
  .| ...| . .. . | .| | | .        | | |  |  |||.|||  .   | .| .. |        |  |||||||||||... ||. |.|
..kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdsl.pgarpwvihcsagvgrtgaflvidamlrq

VQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDA
 ...  |.|   .  .|. | .||||  || ..|  ||.|
akkqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 52-145 2.1e-06 21.5 In-house 92-182 (244) alignment 
Range on Protein: 52-145
Range on HMM: 92-182/244.0
KAPENIVKNRYVNITAYDASRVVLKDH--DTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTreletNVLKCHRYWPEDN
  |.|  |||      .| .|| |        |||||.         .| || |.  .  ||| |.   .|  .|..       | .   |||. .
fnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlg.....sveeedeywpdse
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 55-284 2.7e-57 188.7 In-house 2-236 (237) alignment 
Range on Protein: 55-284
Range on HMM: 2-236/237.0
ENIVKNRYVNITAYDASRVVLKDH--DTDYINASWCPSYT-SPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNAEVQYG
|| .|||| ||.||| ||||||    ..|||||..  ..  .|. .||.|||. || |||| |.|  |   |||.|  .| | ||||.|||. .    ||
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

KVKVKFTRSAMHAHHIERHFEVGLASG-GPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHER-DTKAPICIHCSAGVGRTGTYIAIDTALQQVQE
.. | ...    . .  | . .         | . |  | ||||.|||  .  .| || ....  .     .|  ||||||||||| .. ||. |.| .|
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqake

RAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVL
.  |.|   .  . . | ...||  || ..|...|
kkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 55-286 9.7e-56 183.7 In-house 19-263 (270) alignment 
Range on Protein: 55-286
Range on HMM: 19-263/270.0
ENIVKNRYVNITAYDASRVVLK----DHDTDYINASWCP-SYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNAE--
 . . ||| .|    |.||.|.    |. | |||| . .    ... .||..||.|..  .|| |||. ||  |||.|   | .  || ||||... |  
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

-VQYGKVKVKFTRSAMHAHHIERHFEVGlaSGGPTRDVVQLAFQSWPDHGVPLTSV------EFLEFRAEVLKFHERDTKA-PICIHCSAGVGRTGTYIA
 ...||.||  . .. .  .| .. ..   . | .| .|   ...||||||| ..       . |.  ..| .....  || |. .||||||||||| ||
kledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDA
.|.|.. ..|. .|.. ||| .||..|  .||.. ||....|.|.  
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 55-283 9.1e-50 164.0 In-house 37-273 (287) alignment 
Range on Protein: 55-283
Range on HMM: 37-273/287.0
ENIVKNRYVNITAYDASRVVLK---DHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNAEVQYG
 .. |||| ..  .| .||.|    .. .||||| . .|||    |||.|||....  ||| ...  ..  ....|||.|   |||..|||| .  .. |
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

KVKV-KFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHE--RDT--KAPICIHCSAGVGRTGTYIAIDTALQQ
   |  . .. .. ..  | . .  . .  .| | || . ||||.... |.| .. |  .| .. |  ||.    |. .|...|.||.|...|. . ...
GysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsr

VQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVV
 ..  .|.. |.. .||..|. .||.| |. .. . .
ledlGrvdvaavvirlreyraalvqavvqlrllyeal
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 55-296 1.7e-44 146.7 In-house 54-295 (305) alignment 
Range on Protein: 55-296
Range on HMM: 54-295/305.0
ENIVKNRYVNITAYDASRVVLK-DHDTDYINASW--CPSYTSpRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNAEVQYG
 .| |||| .. . | | | |.    .||| | .  ||     . ||..|||.  . |.||||.   || .|||. . .|.  ||| .|||  . | .  
iaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipe.krficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel

KVKVKFtRSAMHAHHIERHFEVGLA------SGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVlkfheRDTKAPICIHCSAGVGRTGTYIAIDTALQ
|  .        .. .||  |. ..      ||. .  | .| .  ||| |||   .  ||. . .     | .| || .|||||.||||| .||.  |.
ksgivv.envsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai.....rgskvpivvhcsagigrtgtivaieyile

QVQERAEV-NIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLdalNNWLKKHKD
.. |  ..  .  ..  ||..| | .|.  || ..|.|.|   | .|.|.|.
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvml...nyflekyke
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 55-295 3.9e-35 116.3 In-house 42-280 (288) alignment 
Range on Protein: 55-295
Range on HMM: 42-280/288.0
ENIVKNRYVNITAYDASRVVLKDHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNAEV-QYGKV
.| ...|| |.   |..|| |.|    ||.|   .|   .| .| .| |. .  . .| |. .  |  |||... ||    |   |.|    |  ..|..
anptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl

kvkFTRSAMHAHHIERHFEVGLASG---GPTRD-VVQLAFQSWPDHGVPLTSVEFLEFRAEVlkfheRDTKAPICIHCSAGVGRTGTYIAIDTALQQVQE
    |    .   |..  .| |      | ..  | .| .. |.|.|||   . .| .   .     .... || .|.||||||||| | |  ||.... 
...ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrl

RAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALN-NWLKKHK
   . |  .. .||..|   .||  || |||..||. |   . |. .
ddflgirsllaklreerfkaiqtemqylyvhrcvleelllkkykvlr
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 55-294 3.6e-24 79.7 In-house 50-288 (302) alignment 
Range on Protein: 55-294
Range on HMM: 50-288/302.0
ENIVKNRYVNITAYDASRVVLKDHDTDYINASWC--PSYTspRGFIATQGPVPSSF---DDFWWMIWSYKVGEIVMVTRELETNVlKCHRYWP-EDNAEV
.|. ||.  .. ..|. .| |. .  .|.|||    |. |  |  | .| |. .|    ..|| |... |. ..|.. .| | .    . ..| . .. .
knlkknqsedvpildsnlvkleaepdsyvnaskvevPelt..rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdyk

QYGKVKVKFTRsAMHAHHIERHFEVGLASGGPTRDVVQL--AFQSWPDHGVPLTSVEFLEFRAEVlKFHERDTKAPICIHCSAGVGRTGTYIAIDTALQQ
.|||. |   .   .|.  . .. . .   | .  |.     .. |... ||    |  .  |.|   .. ...... |    |.|| |. ..  .|...
eygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavavek

VQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLdalnNWLKKH
.|. .|.||  |. ..|. |  .|... ||. .. ..|     ..||.
lqkgkepnikeivksiRsqRpravdslkQyvslyiall....lyikkk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 55-156 1e-21 72.1 In-house 46-163 (350) alignment 
Range on Protein: 55-156
Range on HMM: 46-163/350.0
ENIVKNRYVNITAYDASRVVLK---------D---HDTDYINASWC----PSYTSPRGF--IATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLK
|   ||||.||  |. ||| ||         .      |||||..     .|     .|  ||||.|.|| .|||. .|   ||  |...| . | |. |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CHRYWPEDNAEVQygKVKVK
|.|||.| . . .  .||..
cyrYWqegsyddi..tvkla
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 55-156 1.1e-14 48.8 In-house 51-155 (310) alignment 
Range on Protein: 55-156
Range on HMM: 51-155/310.0
ENIVKNRYVNITAYDASRVVLK---DHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNAEVQYG
... |||| ..   |.||| ||       ||| | .  .      || .|||.  .  ||| ||.  .   |... .  |    ||  |||       ||
kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

KVKVK
 ..| 
cirvt
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 55-162 2.4e-13 44.1 In-house 47-170 (349) alignment 
Range on Protein: 55-162
Range on HMM: 47-170/349.0
ENIVKNRYVNITAYDASRVVLKDH------------------DTDYINASWC--PSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNV
|   |||| .|  |. |||.||                      ||||| .   . ..  . .|||| |.||. |||. .|   .|  .. .. . |...
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl

LKCHRYWPEDNaevqYGKVKVKFTRSAM
 ||..|| | .    |  ..||.  | .
ekcdiywqels....ysnitvklqnssl
Y_phosphatase Protein-tyrosine phosphatase 56-284 4.2e-73 241.0 Pfam-A 1-234 (235) alignment 
Range on Protein: 56-284
Range on HMM: 1-234/235.0
NIVKNRYVNITAYDASRVVL--KDHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWP-EDNAEVQYGK
|  |||| .|..|| .|| |  .....|||||..  .|.... |||||||..|...|||.|.| .||  |||.|.. | .  ||..||| |.. ...||.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

VKVKFT-RSA-MHAHHIERHFEVGLASGGP-TRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHeRDTKAPICIHCSAGVGRTGTYIAIDTALQQVQE
.||. . ..   ... . |..|.    .   .| | || ...||||||| .. ..|..  .| | . .....|...|||||||||||..|.|..|.|...
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

RAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVL
. ||..  |. .||..|. |||...||....|..|
eeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 56-284 4.2e-73 241.0 In-house 1-234 (235) alignment 
Range on Protein: 56-284
Range on HMM: 1-234/235.0
NIVKNRYVNITAYDASRVVL--KDHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWP-EDNAEVQYGK
|  |||| .|..|| .|| |  .....|||||..  .|.... |||||||..|...|||.|.| .||  |||.|.. | .  ||..||| |.. ...||.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

VKVKFT-RSA-MHAHHIERHFEVGLASGGP-TRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHeRDTKAPICIHCSAGVGRTGTYIAIDTALQQVQE
.||. . ..   ... . |..|.    .   .| | || ...||||||| .. ..|..  .| | . .....|...|||||||||||..|.|..|.|...
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

RAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVL
. ||..  |. .||..|. |||...||....|..|
eeevdvlqivkelRkqRpgmvqsleqYiflykail
0041856 (Phosphotyrosine protein) phosphatases II 56-287 2.2e-45 149.8 In-house 1-171 (182) alignment 
Range on Protein: 56-287
Range on HMM: 1-171/182.0
NIVKNRYVNITAYDASRvvlkdhDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTreletnvlkCHRYWPEDNaevqygkvkv
|. ||||..|  || ||      | |||||..  ..  .. ||||||| .|.. ||. |....... ||..|         ...||||.           
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell..........

kftrsamhahhierhfevglasggpTRDVVQLAFQSWPDHGVPLtSVEFLEFRAEVLKfherdTKAPICIHCSAGVGRTGTYIAIDTALQQvqeraEVNI
                         .| ..|. . .|||||||    |.|.|  |||.      . |. .|||||||||||..|..  ...     .|..
.........................erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsl

DAIIGQLRQHRNFMVQTVAQYAYVHKVVLDAL
. .. ..|..|. ||.|  || ... ..|. |
eeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 56-285 3.8e-39 129.1 In-house 56-281 (290) alignment 
Range on Protein: 56-285
Range on HMM: 56-281/290.0
NIVKNRYVNITAYDASRVVLKD-HDTDYINASWCPSYTSPrgFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNAEV-QYGKV
.. |||| ...  | .||.||| .| ||. | .     ..  || |||.. ..  |.| |.   ||  |||.   .|    ||..|.|| . ||  .|..
efkknrykdvvcndktrvilkdGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGei

KVKFTRSAMH-AHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVlkfheRDTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAE
 |  . .  . |. | . . |     |    .  |  .||||. |.|... .|     .     | .  |. .|||||.|||||..||...|| . .  |
tvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril.....rkasGpvvvhcsaGiGrtGtfvaievglqilldGke

VNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLD
...  ..  ||. |   ||   ||  . ...||
ldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 56-285 1.9e-38 127.0 In-house 35-268 (285) alignment 
Range on Protein: 56-285
Range on HMM: 35-268/285.0
NIVKNRYVNITAYDASRVVLKDHDTDYINASWCPSYT-SPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNAEV-QYGKV
|   ||| .. . . .|||||.|| ||| |||          .|.||||.| .. ||| ||.  |.  ..|.   .|  | ||  |.||   || ..|| 
npdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgky

KVKFTRSAMH--AHHIERHFEVGL---ASGGPTRdVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHERDTkaPICIHCSAGVGRTGTYIAIDTALQQVQ
.. .|       |  |   . |     ||  |   . ..    |||.  |  .  ..|.   | |   ...  |||.||||||||| |.. || |  .. 
eitlteckeeaiagtilnaltvintedasseply.mnhvqvpwwpdqlapedarpmielykwvkkvnpkek..picvhcsagvgrtatfvgidyatirim

ERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLD
|  ....  |. ..|  |   ||.  |. ... |...
enpniemldivremramrfqavqshmqflflyvvlme
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 59-279 1.3e-38 127.4 In-house 53-273 (301) alignment 
Range on Protein: 59-279
Range on HMM: 53-273/301.0
KNRYVNITAYDASRV-VLKDHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNA-EVQYGKVKVK
|.|| ..     . | |..|     | | | |.   |. |||||||.... .||| |.  |.| .|||.....| .. ||. | | . . ... |. |.|
khryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkik

F--TRSAMHAHHIERHFEVGLASGG-PTRDVVQLAFQSWPDHGVPLTSVEFLEFrAEVLKfherDTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEV
   . . .. . ..|..||  ..|  .|| |.   ...|.|.||| . .|  ..  |..|    ... || .|||||.||. ..|. .   ..|.   ..
iknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdl.melvk....ksekPivvhcsaGiGrsvafigteylareveadpti

NIDAIIGQLRQHRNFMVQTVAQYAYV
..   . .||.||   |||. |  ..
eltealkhlrehrwngvqtnsqlywm
subfamily_CG42327_pd Subfamily CG42327 59-201 6.1e-15 49.7 In-house 31-180 (319) alignment 
Range on Protein: 59-201
Range on HMM: 31-180/319.0
KNRYVNITAYDASRVVLK----DHDTDYINASWCPSYT-SPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNA---EVQY
|.|..|.     .||||.    |  . |..||.   |  .|  .||.| .  .|  ||| ..|  .   || .|   |  . .| .|.|  ..   .  |
ksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsly

GKVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFqSWPDHGVPLTS
|...| .   . . ...   . .    .  .|..    .  |.. .||   
Gdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaee
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 60-304 2.1e-28 93.9 In-house 47-295 (312) alignment 
Range on Protein: 60-304
Range on HMM: 47-295/312.0
NRYVNITAYDASRVVLKDHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNAEVQYGKVKVkFTR
||| ||  .|  |  |   .  || | .    | |  |..||||. ..   || .  |     |....  .|    || .|  .  . |.    .| .| 
nrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv.yte

SAM--------HAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEfraeVLKFHERDtKAPICIHCSAGVGRTGTYIAIDTALQQVQERA
.          . .   | . | . . |    . .  . ||||||.| .    |     .|    .| | |.  ||||||||||| . |.. .  ..   
ycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalr....llsavkkd.kkpviahcsagvgrtgtlaliesmiaalrhpr

EVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNN--WLKKHKDIIDRERER
  |.  .   ||. |   |....|| |. ..||. | .    |. ..   . .| 
kqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrneqewtkfket
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 64-310 1.2e-24 82.0 In-house 26-262 (290) alignment 
Range on Protein: 64-310
Range on HMM: 26-262/290.0
NITAYDASRVVLKDHDT----DYINASWCpSYTSPRGFIATQGPVP-------SSFDDFWWMIWSYKVGEIVMVTRELETNVL----KCHRYWPEDNA-E
...   |.|||||.. .    ||| |.   .. .   .|.|| |         |   .||||.   || ..||.    | .       | .| ||    |
evpLveatrvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgee

VQYGKVKVKFTRSAMHAHHIERHFEVGLASgGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVlKfherDTKAPICIHCSAGVGRTGTYIAIDTALQQV
.... ..|| .    .   ..|. .|     .    |    ...| .  |. ..  .|.    | |      |.|. .||  |. |  .  ||. . | .
lkfkgltvkCkskekeddvetRelvvkfdd.eeeftvtHsllkgWnklnvqedtktllsliqkv.k....asktpvivHcvdGiSrsAalaaiilgyQki

Q-ERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLdalnnwlkkhkdiidrererMAAEQA
   . .|.. ... .||..|. ....  ..|.|  ...                    . | ..
aetsgsvkledvlkalrkqralaitsalelafvdagiv....................llaiev
0046846 (Phosphotyrosine protein) phosphatases II 74-285 9.6e-39 128.3 In-house 6-171 (176) alignment 
Range on Protein: 74-285
Range on HMM: 6-171/176.0
VLKDHDTDYINASWCPSYTsprgFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEdnaEVQYGKvkvkftrsamhahhierhfev
   | | |||||..  ..     .||||||.|... ||. |....... .|..| | |.. |||..||||   . ..|                      
lgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi.....................

glasggptrdvvQLAFQSWPDHGVPLTsVEFLEFRAEVLKFHERDtkAPICIHCSAGVGRTGTYIAIDtalqQVQERAEVNIDAIIGQLRQHRN-FMVQT
            |  .  |||||||     .||. ... .. ...   |. .|||||.|||||..|..     .. .  .... .. ..|..|  ..|||
............qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqt

VAQYAYVHKVVLD
 .|| ......| 
peQyrflyefell
0043147 (Phosphotyrosine protein) phosphatases II 77-280 5.6e-41 135.5 In-house 2-154 (172) alignment 
Range on Protein: 77-280
Range on HMM: 2-154/172.0
DHDTDYINASWCPSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTREletnvlkchrywpednaevqygkvkvkftrsamhahhierhfevGLA
|...||||||. . |  |. ||||||| .. ..||| |....... ||..|..                                             . 
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lyd

SGGPTRDVVQLAFQSWPDHGVPlTSVEFLEFRAEVLKFHERDTKAPICIHCSAGVGRTGTYIAIDTALqqvqerAEVNIDAIIGQLRQHRNFMVQTVAQY
  . .| ..|. . .||||||| ..  .|||   . ... .. . |...||||||||||| .|..  |        .... .. ..|..|. .||.  ||
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

AYVH
 ...
rfly
0051082 (Phosphotyrosine protein) phosphatases II 79-283 1.7e-33 110.7 In-house 2-149 (151) alignment 
Range on Protein: 79-283
Range on HMM: 2-149/151.0
DTDYINASWCPSYtsprgFIATQGPVPssfdDFWWMIWSYKVGEIVMVTRELETNvlKCHRYWPEDNaevqygkvkvkftrsamhahhierhfevglasg
 .||||.|.  ..     .....|| .    ||. .......  ||... | |..  .|..|.|| .                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

gptRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKfherDTKAPICIHCSAGVGRTGTYIAIDTALQQvqeraeVNIDAIIGQLRQHRNFMVQTVAQYAY
   ..|... . .|||.|.||.  ..|||  ..|.    . . |. .|||||.||||| .|..  |..      |...... ..|..|  .||.  |. .
...ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

VHKVV
.....
qlfal
0044763 (Phosphotyrosine protein) phosphatases II 79-282 2e-29 97.9 In-house 17-166 (178) alignment 
Range on Protein: 79-282
Range on HMM: 17-166/178.0
DTDYINASWCPSYtsprgFIATQGPVpssfDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNAevqygkvkvkftrsamhahhierhfevglasg
 .||||||.   .     ..... |      |.. ... .... ||..| ||| . |||..||||..                                 
rsdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................................

gptrdvVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHErDTKAPICIHCSAGVGRTGTYIAIDTALQQvqeraEVNIDAIIGQLRQHRNfMVQTVAQYAY
      .|  .  .||||||  .  |||| . . .... . . |. .||||||||.|| .|..  ...      ......| ..|..|. .|..  |. .
......iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrq

VHKV
....
Lyef
0051429 (Phosphotyrosine protein) phosphatases II 80-304 1.4e-48 161.2 In-house 4-242 (272) alignment 
Range on Protein: 80-304
Range on HMM: 4-242/272.0
TDYINASWCPSYTS---PRGFIATQGPVPSSFDDFWWMiWSYKVGEIVMVTRELETNVLKCHRYWP-----------EDNAEVQYGKVKVKFTRSAMHAH
..||||.. . |..   |. .....|| | . .|||.. .....  ||....| | . |||.||||           ..  .. ||.. |...   .. .
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

HIERHFEVGLA-SGGPTRDVVQLAFQSWPDHGVPLTSveFLEFRAEVLKfherdtKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVN--------ID
.| |.... |  | | .| | .| ...|||||||  .  .||. ...|.      . |. .|||||..||||..|..  |..| . . |.        ..
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

AIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNNWLKKHKDIIDRERER
... .||..|  .||| .||.......|..|...|  . . ...  . 
eaveelraqrpgavqteeqylflyeallellrsllsvraeyllaalda
0036282 (Phosphotyrosine protein) phosphatases II 80-281 3.4e-44 145.9 In-house 2-164 (174) alignment 
Range on Protein: 80-281
Range on HMM: 2-164/174.0
TDYINASWCPSYTSPRGFIATQGPVPssfddFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEdnaevqygkvkvkftrsamhahhierhfevglASGG
.||||||..  .  ....||.||| .     || |......  .||...| | .  ||..||||                                 .  
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

PTRDVVQLAFQSWPDHGVPLTSVeFLEFRAEVLKFHERDTKAPICIHCSAGVGRTGTYIAIDTALQQVQeRAEVNIDAIIGQLRQHRNFMVQTVAQYAYV
..| ..|. .  ||||||| .|. .|||  .| .....| . |. .||||||||||| .|..  |..      |.. ... .||..|  ||||  || ..
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

HK
..
yy
0049260 (Phosphotyrosine protein) phosphatases II 89-281 3.9e-37 122.6 In-house 3-144 (152) alignment 
Range on Protein: 89-281
Range on HMM: 3-144/152.0
PSYTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWpednaevqygkvkvkftrsamhahhierhfevglasggptrdvvQLA
. |  |. ||||||| | ...||| |....... |||.|..|| . |||..|.                                            |  
dgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qyl

FQSWPDHGVPLTSVEFLEFRAEVLKFhERDTKAPICIHCSAGVGRTGTYIAIDTALqqvqerAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHK
.  |||||||  |  .|..   . |.  .| . |. .|||||||||||..|..  |        |... .. ..|..|. .|..  |. ....
hlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 91-157 3.1e-08 27.4 In-house 232-295 (440) alignment 
Range on Protein: 91-157
Range on HMM: 232-295/440.0
YTSPRGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTReleTNVLKCHRYWPEDNAEVQYGKVKVKF
|.    ||||| |. |.  ||| ..  |..  |.|. .    |   |  ||| .   | .|   |  
yskknafiatqmpldstvldfwrlvhdyristiimlnq...lndktcsiywpvntrsvtfgpftvgh
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 95-281 1.1e-21 71.9 In-house 5-198 (199) alignment 
Range on Protein: 95-281
Range on HMM: 5-198/199.0
RGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNA-EVQYGKVKVKFTRSAMHAHH-IERHFEVG-LASGGPTRDVVQLAFQS
| .|||| |.  .. ||| |.|    | ||||  .   .      |||  ..   .|| . |     . .. . |     .   ..   ||.. .  | |
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPLTS--VEFLEFRAEVLKFHERDTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAE--VNIDAIIGQLRQHRNFMVQTVAQYAYVHK
| ..  |  .  | |.    || | .|..  ||. .||| | | || ..|.|  ..  .|     |..  .  .||| |  .. .. .| ....
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 95-281 1.2e-21 71.8 In-house 4-197 (198) alignment 
Range on Protein: 95-281
Range on HMM: 4-197/198.0
RGFIATQGPVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNA-EVQYGKVKVKFTRSAMHAHH-IERHFEVG-LASGGPTRDVVQLAFQS
| .|||| |.  .. ||| |.|    | ||||  .   .      |||  ..   .|| . |     . .. . |     .   ..   ||.. .  | |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPLTS--VEFLEFRAEVLKFHERDTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAE--VNIDAIIGQLRQHRNFMVQTVAQYAYVHK
| ..  |  .  | |.    || | .|..  ||. .||| | | || ..|.|  ..  .|     |..  .  .||| |  .. .. .| ....
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 103-287 2.2e-19 64.0 In-house 99-288 (302) alignment 
Range on Protein: 103-287
Range on HMM: 99-288/302.0
PVPSSFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDN-AEVQYGKVKVKFTR-----------SAMHAHHIERHFEVGLAsgGPTRDVVQLAFQ
|  |. . .| .|  |.|. .| ..   | .  ||  |. ..   |...|.  ||               ... . .| . |         . |  ||| 
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkk..kvkktvdilafs

SWPDHGVPLTSVEFLefraEVLKFHERdTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDAL
.||||| |  .   |    ..||| |   |  . .||||||||||| .||   .|  ...   ..  |.  .|| |   ||.  |  |.  .|  .|
awpdhGapkeaytal....dilkfces.ykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkgl
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 106-308 8.7e-12 38.3 In-house 129-330 (346) alignment 
Range on Protein: 106-308
Range on HMM: 129-330/346.0
SSFDDFWWMIWSYKVGEIV-MVTRELETNVlkCHRYWPEDNAEVQY-GKVKVKFTRSAMHAHHIERHFEVgLASGGPTRDVVQLAFQ-SWPDHGVPLTSV
|  .|||.||.  ..  .  ||  .   |       . ..|   || ||. ..  |. .     |   || |  |     ..|.  .  |     |  ..
sfvedfwymiyqeqihlvylmvpddklknt..ttslfndenggyqytgkmfinnrradvsgdpkeytiev.lpegnsdsvicqvhhhapwkhlqqppktl

EFLEFRAEVLKfHERDTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNNWLKKHKDIIDRER
  . .  . |   ..  .| .|.    | ||. ..|    |..|...  | ||  |. ...| |   |.. |||| .. .|.| .      .|. .... 
piikmihqfls.ekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiarkrggkkapvnkdi

ERMAAE
.|. .|
nrfide
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 107-287 5.6e-17 56.7 In-house 40-221 (255) alignment 
Range on Protein: 107-287
Range on HMM: 40-221/255.0
SFDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNAE-VQYGKVKVKFTRsaMHAHHIERHFEVGLASG--GPTRDVVQLAFQSWPDHGVPLTSVE
. | |. .|   |  ..||..   | .| ||..|.| .  |  .. .|.|  |.    |. . |  |. .  |    |..|    .. |...  |  . |
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

FLEfraeVLKFHeRDTkAPICIHCSAGVGRTGTYIAIDTALQ----QVQERAEVNI--DAIIGQLRQHRNFMVQTVAQYAYVHKVVLDAL
 |.    .||   ||.  .. .|||.|.||. ... .. . |    ....   |..    .. .||..|.  ..|  | |.   .||| .
iln....ilkvv.rds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_hpo-7_pd Subfamily hpo-7 108-292 2.7e-14 47.7 In-house 47-232 (263) alignment 
Range on Protein: 108-292
Range on HMM: 47-232/263.0
FDDFWWMIWSYKVGEIVMVTRELETNVLKCHRYWPEDNA-EVQYGKVKVKFTRSAMhaHHIERHFEVG--LASGGPTRDVVQLAFQSWPDHGVPLTSVEF
 | |. .|   |  ..||..   | .| || .|.| .     .. .|.|  |..      . .  |.   |     |..| .  .. |...  |  . | 
idkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelarei

LEfraeVLKFHeRDTkAPICIHCSAGVGRTGTYIAIDTALQ----QVQERAEVNID--AIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNNWLK
|.    .||   |.   .. .|||.|.||.  .  .... |    ....   |..|   .. .||..|.  ..|  | |.   .||| . |   
ln....ilkva.rns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfa
0048179 (Phosphotyrosine protein) phosphatases II 116-281 5.1e-21 70.4 In-house 26-139 (144) alignment 
Range on Protein: 116-281
Range on HMM: 26-139/144.0
WSYKVGEIVMVTRELETNVLKCHrywpednaevqygkvkvkftrsamhahhierhfevglasggptrdVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFH
...... .. .| | | . |...                                             ..|. . .|||||||  .  .||| . . ...
kklgittvinlteeyepeflere.............................................giqylhlpwpDhgvpdllellleflefieeal

ERDtkAPICIHCSAGVGRTGTYIAIDTALqqvqeRAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHK
|..   |. .|||||||||||..|..  .     .  .... .. ..|..| ..|..  |. ....
eeg..gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 129-282 3.6e-06 20.7 In-house 142-297 (332) alignment 
Range on Protein: 129-282
Range on HMM: 142-297/332.0
ELETNVLKCHRYWPEDNAEVQYGKVKVKFtrSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVpLtSVEFLEFRAEVLKFHER-DTKA-----P
| | .   |...||| ... ..  . ..   |  |.    . |.. ..     .. | . |  | |    |    .|..|| .   . |   |.     |
ecelkakicrkfwpekrskkdfpalsiqa..sddhsethmktfnltvtekkqdhqtvlmhfyewadask.l.peymldmrasiklqyirsskktgvcigp

ICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKV
| . |..|| .   . .||  . .. |   | .   .  .. .|   ..||  |.   ..
imlvcatgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystacem
0048076 (Phosphotyrosine protein) phosphatases II 149-283 5.6e-23 76.6 In-house 12-139 (145) alignment 
Range on Protein: 149-283
Range on HMM: 12-139/145.0
QYGKVKVKFTRSAMHAHHIERHFEVGLASGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHERDtkAPICIHCSAGVGRTGTYIAIDTALQqvq
 .| . .   .  .. ..| . . .     ...| ..|. . .|||||||  .  .||| . . ......   |. .|||||||||||..|..  |.   
ylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll...

erAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVV
    |... .. ..|..| ..|... |. ......
..lgvsleealelvrsqrpgavpnpgqlrflyefe
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 165-284 7.6e-15 49.5 In-house 199-341 (350) alignment 
Range on Protein: 165-284
Range on HMM: 199-341/350.0
HHIERHFEVGLASGGPTRdVVQLAFQSWPDHGV---PLTSVEFLEFRAEVL------KFHERDTKAPICIHCSAGVGRTGTYIAIDTALQ------QVQE
.. .   .. ||.  |   | || .. |.| ..   |   .. || . ...      .. . .  .|| .|||||||||||....|  |.      ....
kdnnsltaitlaasdPyv.vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltk

RA---------EVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVL
.          .  |  |. .||. |  |||.. |. .... .|
esrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 177-299 4e-22 73.1 In-house 84-208 (440) alignment 
Range on Protein: 177-299
Range on HMM: 84-208/440.0
SGGPTRDVVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHERDTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQY
.|  .| . |  .|.|||.|||  .   |..  .| . .|.  ..|. .|||||.||||  ||.|. |....   ...| ..|  .|. |  ||||  ||
ngiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqy

AYVHKVVLDALN--NWLKKHKDIID
|.||..||..|   . |  . || .
afvheavlegllcgdtlileddite
PTEN_1 179-239 1.5e-06 23.1 In-house 85-149 (196) alignment 
Range on Protein: 179-239
Range on HMM: 85-149/196.0
GPTRDVVQLAFQ----SWPDHGVPLTSVEFLEFRAEVLKFHERDTKAPICIHCSAGVGRTGTYIA
.. ..  .  ..    ...|||.|  |  | . .       ... .  . .|| ||.||.|| .|
ydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 183-284 1.8e-10 34.7 In-house 219-341 (349) alignment 
Range on Protein: 183-284
Range on HMM: 219-341/349.0
DVVQLAFQSWPDHGVPLT---SVEFLEFRAEVL------KFHERDTKAPICIHCSAGVGRTGTYIAIDTALQ------------QVQERAEVNIDAIIGQ
 ..|| .. |.| .. |     .. || . ...      .. . |  ... .||||| ||||... .|  |.            ..|   .  |  |. .
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

LRQHRNFMVQTVAQYAYVHKVVL
||. |  ||| .||.  ... .|
lrkqrismvqnlaqfiaiyealL
PTPc_DSPc_SM00012 184-284 4.9e-32 105.6 In-house 2-104 (105) alignment 
Range on Protein: 184-284
Range on HMM: 2-104/105.0
VVQLAFQSWPDHGVPLTSVEFLEFRAEVLKFHERDT-KAPICIHCSAGVGRTGTYIAIDTALQQVQER-AEVNIDAIIGQLRQHRNFMVQTVAQYAYVHK
| .. . .||||||| .| ..||. ..| |...  . ..|...|||||||||||..|.|..|||....  ||.|  |. .||..|. |||| .|| ....
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VVL
..|
all
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 187-284 1e-11 39.0 In-house 195-287 (310) alignment 
Range on Protein: 187-284
Range on HMM: 195-287/310.0
LAFQSWPDHGVPLTSVEFLEFRaevLKfhERDTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVL
. .  ||| |||   .  .  |   |    .  . |  .|||||..|... .|.. .......  .|... .. .|...|   .||  || ....| .
ikwpnwpdrgvpdekchtvpqr...ll..aqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri
subfamily_PTPDC1_pd Subfamily PTPDC1 190-281 1.6e-06 22.7 In-house 88-170 (182) alignment 
Range on Protein: 190-281
Range on HMM: 88-170/182.0
QSWPDHGVPltSVEFLEFRAEVLKFHERDTkaPICIHCSAGVGRTGTYIAIDTALQQvqeraEVNIDAIIGQLRQHRNFMVQTVAQYAYVHK
 .|.|.||.  |.| .     |..|  ..    . .|| || ||||  ||     ..     ... .  |  .|..|   .||  |   |..
fgwkDygva..sleriLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyak.....rltaekaiklvrskrpksiqtreqvelvke
0038934 (Phosphotyrosine protein) phosphatases II 191-286 4.2e-10 35.1 In-house 86-176 (194) alignment 
Range on Protein: 191-286
Range on HMM: 86-176/194.0
SWPDHGVPLTSVEFLEFRAEVLKFHERDTKAPICIHCSAGVGRTGTYIAIdtALQQVqerAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDA
 .||.|.. .    |.|   | .|...|..  . .|| ||.||||| .|   .| ..      . .. |. .|. |. ..... .. ...| . . 
pfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa..YLiyr...lgmsaeeAialfrekRpgaipnqdyleallkrykel
subfamily_VSP_pd Subfamily VSP 194-282 1.7e-07 25.3 In-house 103-194 (212) alignment 
Range on Protein: 194-282
Range on HMM: 103-194/212.0
DHGVPLTSvEFLEFRAEVLKFHERDTKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAiIGQLR-----QHRNFMVQTVAQYAYVHKV
|| ||  . |.| |  || .. |.|.|  . |||  | ||||| .       .. |.|.  .|  .|. |      ..   ||| .|. ||. .
dhnvpkle.ellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldy.fgerrtdktegekfqGvqtpsqkryvgyl
subfamily_PTEN_pd Subfamily PTEN 194-280 1.9e-07 26.3 In-house 89-173 (184) alignment 
Range on Protein: 194-280
Range on HMM: 89-173/184.0
DHGVPLTSVeFLEFRAEVLKFHERDTKAPICIHCSAGVGRTGTYIAIDtALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVH
||  |  .. . |.  .. |. |.|.|  . .|| || ||||. |.    |.. . . . .. ..  . | . .  |.  .|  ||.
Dhnppplel.leeivediekwleedkknvvvvHCkaGkGRtGvlivay.llkslllekaeealelfaeaRtknkkgvtiPsqrRYve
subfamily_eak_pd Subfamily eak 214-296 1.2e-07 25.4 In-house 231-314 (332) alignment 
Range on Protein: 214-296
Range on HMM: 231-314/332.0
FHERDTKAPIcIHCSAGVGRTGTYIAIDTALQQVQERAE--VNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALNNWLKKHKD
.|   . ||| | .. |  |.|... ||  .. .... .    .. .| . ...|.  | .  |.......||| | .  .. .|
ihtppsfapi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrd
subfamily_CG42327_pd Subfamily CG42327 216-283 1.1e-15 52.1 In-house 243-311 (319) alignment 
Range on Protein: 216-283
Range on HMM: 243-311/319.0
ERDTKAPICIHCSAGVGRTGTYIAIDTALQQVQER-AEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVV
.|. . |. .||| ||||||. || | |.....|    |.|  .. ..|. |   |.|. ||....||.
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 219-287 4.5e-12 40.4 In-house 227-295 (297) alignment 
Range on Protein: 219-287
Range on HMM: 227-295/297.0
TKAPICIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDAL
 .|.. .||||||||.|  .  |. |.... .   .. ||. .||. |  .|||. |. .....||  |
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 224-287 1e-10 35.8 In-house 2-65 (69) alignment 
Range on Protein: 224-287
Range on HMM: 2-65/69.0
CIHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDAL
 .|||.| |||||.|||   . ...    |.|   .  .|. |  ||    .| ..|  . .||
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 225-288 1.2e-10 35.5 In-house 2-65 (69) alignment 
Range on Protein: 225-288
Range on HMM: 2-65/69.0
IHCSAGVGRTGTYIAIDTALQQVQERAEVNIDAIIGQLRQHRNFMVQTVAQYAYVHKVVLDALN
.|||.| |||||.|||   . ...    |.|   .  .|. |  ||    .| ..|  . .|| 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealk