Gene MbrePTP-sf1-6 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily MbrePTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP037_AA protein Get Run
MbreP037_AA_674-941 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
HC2 Histone H1-like nucleoprotein HC2 335-477 7.7e-11 28.6 Pfam-A 4-146 (194) alignment 
Range on Protein: 335-477
Range on HMM: 4-146/194.0
AAEKAAADKAAAE--AAEKAAAEKAAAeaaEKAAAEKAAAEKAAAEKAAAEAAEKAAAEAAEKAAAEKAAAEKAAAEKAAAEKAAAEKAAAEKAAAEKAA
.. | .. |.||   |. |.|| ||||   .|... |.|| |.|| |..| ..  .   || |||| |||  ||.|.|..|.|..| ||.| |||| |..
vqKKrsskKtAakkaavrKpaAkKaaa...kktvvrKvaaKKtaarKtvakktvakkkvaakkaaakkaavkkavakkvvakkkvakKavAKKaaakKvv

AEKAAAEKAAAEK-AAAEKAAAEKAAAEKAAAEKAAAEKAAAEKAA
| |..| |..| | ||| |.|| ||.| |||| |||| ||.| |||
akkvvakKtvakkaaaakKpaakkavakkaaarKaaakKavaKkaa
HC2 Histone H1-like nucleoprotein HC2 391-527 4.5e-15 42.4 Pfam-A 8-146 (194) alignment 
Range on Protein: 391-527
Range on HMM: 8-146/194.0
EAAEKAAAEKAAAEKAAAEKAAAEKAAAEKAAAEKAAAEKAAAEKAAAEKAA-AEKAAAEKAAAEKAAAEKAAAEKAAAEKAAAEKAAAEKAAAEKAAAE
... |.|| |||. |.|| ||||.|... |.|| |.|| |..| |. |.| . | |||| |||  ||.|.|..|.|..| ||.| |||| |..| |..| 
rsskKtAakkaavrKpaAkKaaakktvvrKvaaKKtaarKtvakktvakkkvaakkaaakkaavkkavakkvvakkkvakKavAKKaaakKvvakkvvak

KAAAEK-AAAEKAAAEKAAAEKAAAEKAAAEKAAAEKAA
|..| | ||| |.|| ||.| |||| |||| ||.| |||
KtvakkaaaakKpaakkavakkaaarKaaakKavaKkaa
HC2 Histone H1-like nucleoprotein HC2 460-594 1.2e-16 47.5 Pfam-A 7-148 (194) alignment 
Range on Protein: 460-594
Range on HMM: 7-148/194.0
KAAAEKAAAEKAAAEKAAAEKAAAEKAAAEKAAAEKAAAEKAAAEKAAAE------KAAAEKAAAEKAAAEKAAAEKAAAEKAAAEKAAAEKAAAEKAAA
| .. |.|| |||. |.|| ||||.|... |.|| |.|| |..| |. |.      |||| |||  ||.|.|..|.|..| ||.| |||| |..| |..|
KrsskKtAakkaavrKpaAkKaaakktvvrKvaaKKtaarKtvakktvakkkvaakkaaakkaavkkavakkvvakkkvakKavAKKaaakKvvakkvva

EKAAAEK-AAAEKAAAEKAAAEKAAAEKAAAEKAAAEKAAAE
 |..| | ||| |.|| ||.| |||| |||| ||.| |||. 
kKtvakkaaaakKpaakkavakkaaarKaaakKavaKkaast
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 668-945 3.7e-85 280.8 In-house 8-285 (318) alignment 
Range on Protein: 668-945
Range on HMM: 8-285/318.0
MRRIQQLDQptdSGYSGYAEEYEGITEGNDNTSQ---ATRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVS
 .....| .   ||.  . |||| ..  ......    .  |.  ||| |..||||.|||. ... ....||||||..|||.  |..||.|.||| |.  
eshvrrlre...sGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieD

FWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEAATKYGDVIVRPLSQEENKVYIKRVFQLQKDG--ETREIAQFEFLNWPDHGAPDSTMDMIEYRTAV
||.|.|||..  |||.| . .  ..|.|.|||.. ...||.. |   .. | . |. | |......  |.|.. |... .|||.| |.|......    |
fWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqv

RSYTGLKNKHPIVVHCSAGVGRTGTFIALDRLFRAVDHAdlENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQQLR
...   ....||||||||||||||.|||.| | . . .   . .||  .| ..|. | .|||.  |||.|...|.....    
skaqqksgagpivvhCsaGvGrtGvfiavdillerikae..alvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdt
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 669-941 1.1e-78 259.6 In-house 12-284 (319) alignment 
Range on Protein: 669-941
Range on HMM: 12-284/319.0
RRIQQLDQptdSGYSGYAEEYEGITEGNDNT-SQA-TRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFW
.|...|..   .|  . ..|.. . |....| ..| . .|.  |||.|. |||..||....    ...|||||.|.|||.  ..|||||.||  |   ||
erlkalas...tgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfW

QMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEAATKYGDVIVRPLSQEENKVYIKRVFQLQK---DGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVR
.|.||...  .||.| | .  .||...|||.|  ..|| .|| ....|| . ||.| ..|.|   . ||||. .| ...||||. |.... ...    .|
rmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrir

SYTGLKNKHPIVVHCSAGVGRTGTFIALDRLFRAVDHADLenLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMM
  .  ... |||||||||||||||||.||  .  | .  .  |||  .| ..|  | .|||   ||..|...| ... 
ksrektqsgPivvhCsaGvGRtGtfivldamlervkeegv..lDvfstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_PTPN6_pd Subfamily PTPN6 670-945 1.2e-69 229.6 In-house 12-302 (306) alignment 
Range on Protein: 670-945
Range on HMM: 12-302/306.0
RIQQLDQP-TDSGYSGYAEEYEGITEGN-----DNTSQATRDNRLLNRYSNVTAYDHSRVKVApTSHNNNTDYINANFVDG--YHGPKEFIATQGPLPVT
|...|..  .. . .|. ||.| . . .     . .  |  .|.  ||| |.  .||.||...  ..  ..||||||....      |..||||| |. |
rvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclett

CVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEAA-TKYGDVIVRPLSQEENKVYIKRVFQLQ---KDGETREIAQFEFLNWPDHGAPDSTMDMIE
   ||.|.|....  |||.|  .  .. || .||||| . ..||.. |. .|..... || | ....   |..|.||. |..| .||||| | ..  ...
vsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLd

YRTAVRSYTG-LK--NKHPIVVHCSAGVGRTGTFIALDRLFRAVDHADLE-NLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQQLR
. . |.. .  |.  .. |||||||||.||||||| .| | . . .  |. ..|.. .|  .|. |  .||   || ...|..| |. .. .
fledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkk
subfamily_PTPN14_pd Subfamily PTPN14 670-941 3.9e-58 191.8 In-house 12-297 (300) alignment 
Range on Protein: 670-941
Range on HMM: 12-297/300.0
RIQQLDQPTDSGYsgYAEEYEGITEGNDNTS---QATRDNRLLNRYSNVTAYDHSRVKVAPTSHNnNTDYINANFVDGYHGPK--EFIATQGPLPVTCVS
|...|..  ..|      ||| |.. . ..     .  .|   ||. .|  |...||...|| .| .|.||||  .    | |  ..|..||||. |.  
rakilekkleegk..vfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqd

FWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDE----AATKYGDVIVRPLSQEENKVYIKRVFQLQK--DGETREIAQFEFLNWPDHGAPDSTMDMIEY
||||.|||.   |||.|. ... . |...|.|..       ..|   |    .|. . .| . ..|.    .| |..  . . .||||| |.   ....|
fWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsy

RTAVRSYTGL--------KNKHPIVVHCSAGVGRTGTFIALDRLFRAVDHAdlENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMM
   |.|            ..| |..|||||||||||  |  | |  ...|   |..|.. |.| .|. | ..||.| ||....|.|  |. 
LeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehn..eeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_PTPRK_pd Subfamily PTPRK 671-935 4.7e-73 240.7 In-house 13-272 (314) alignment 
Range on Protein: 671-935
Range on HMM: 13-272/314.0
IQQLdqPTDSGYsGYAEEYEGITEGNDNTSQatRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIW
|..|  ..  || |. |||| . || | . .   .||  ||. .. |||.|||.. ..  ....|||||...|.|. |..||.|||||. |   ||....
iall..kraegy.gfkeeyeslfegwdaakk..denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvy

EQQAVAIVMVTALIQGNRVKCHQYWPDEAATkYGDVIVRPLSQEENKVYIKRVFQLQK----DGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYT
.... .|||.| |..  |||| .|||... . |||. |  .. | .. ...|.|...|      |.||. ||.||.||||. | |   ....   | . .
dencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksq

GLkNKHPIVVHCSAGVGRTGTFIALDRLFRAVDHADLenLDVRAVVANMRHSRTMMVQALPQYEYIHKT
   .. .|||||||| ||||||||.| .   ... ..  .||  .| ..| ... ||..  || .|.  
ee.eaGrivvhCsaGaGrtGtfiaidivldmieregv..vdvfnavktlrsrkvnmveteeqykfiydv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 671-940 1.6e-68 226.0 In-house 12-279 (315) alignment 
Range on Protein: 671-940
Range on HMM: 12-279/315.0
IQQLDQPTDSGYSGYAEEYEGITEGNDNTSQATR--DNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQM
|  . |   |   |. ..|| |  |.    . ..   |.  ||| |. |||.|||..  .  ....||.||||.|||  .. .||.|||.. .   ||..
ityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrl

IWEQQAVAIVMVTALIQGNRVKCHQYWPDEaATKYGDVIVRPLSQEENKVYIKRVFQLQKDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGl
..|..   |||.| |..|.. |. .||||.    || . |   |.| |. |  | .    . . ||. |...  ||| | | .|. ....   |. .   
vfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhht.

KNKHPIVVHCSAGVGRTGTFIALDRLfraVDHADLEN-LDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYM
..  .||||||||||||||||.|| .   .|.|. || .||  .. ..|. |  |||.. ||..|...| . .
nsvgaivvhcsaGvGrtGtfitldav...ldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 672-944 6.7e-125 410.8 In-house 4-280 (281) alignment 
Range on Protein: 672-944
Range on HMM: 4-280/281.0
QQLDQPTDSGYSGYAEEYEGITE-GNDNTSQATR--DNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQM
..|.| ... ..|..||||.... |.|||..|..  .|.| |||||..|||..||||.|...|.||||||||||.||.|.||.||||||.| ..|.||||
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

IWEQQAVAIVMVTALIQGNRVKCHQYWPDEA-ATKYGDVIVRPLSQEENKVYIKRVFQL-QKDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYT
.|||.. ||||||. |.....|||.||||.. ..|||||.|. ...||.. ||.|.|.| ...|||||..|.....|||||.|..|....|.|..|...|
vweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlklt

GLKNKHPIVVHCSAGVGRTGTFIALDRLFRAVDhADLENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQQL
  |.|.|.|.|||||||||||.||||||..||. |.||.|||.||||..|..|..|||.. |||...|...|.....|
ekktkaplvihCsaGvGrtGtyialDrlvkave.aeleeldvkavvaelrkernlmvqtvvqyefvykavldaldkel
0045450 (Phosphotyrosine protein) phosphatases II 675-941 1.4e-76 253.5 In-house 19-305 (307) alignment 
Range on Protein: 675-941
Range on HMM: 19-305/307.0
DQPTDSGYSGYAEEYEGITEGNDN-----TSQATRDNRLLNRYSNVTAYDHSRVKVAPTSHN-NNTDYINANFV--------DGYHGPKEFIATQGPLPV
 . . .. .|...|.| . . ..      .. .   |. .|||... .|||.|||. ..... ...|||||..|        |||. ...||||||||| 
llllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

TCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDE-AATKYGDVIVRPLSQEENKVYIKRVFQLQ---KDGETREIAQFEFLNWPDHGAPDSTMDMI
|. .||.|.|||.  .|||.| |.  .|.||.||||||     ||.. |. || |. . |. |.. ..   ..||.|.. .| ...|||||.|.|. ...
tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeell

EYRTAVRSYTGLK-NKHPIVVHCSAGVGRTGTFIALDRLFRAVDHADLEN-LDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMM
.   .||.. .   ...|..|||||||||||||||.. . | ...    . .|.. .|. .|  |  .|| . ||..... |... .
dfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
0051299 (Phosphotyrosine protein) phosphatases II 676-940 3.9e-87 287.6 In-house 16-286 (288) alignment 
Range on Protein: 676-940
Range on HMM: 16-286/288.0
QPTDSGYSGYAEEYEGITEGN---DNTSQATRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQ
. . .|..|..||.| ... .   . .. .   |.  ||||.. .|||||||. ... ....|||||...|||. ...||||||||| |. .||.|.|||
kllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweq

QAVAIVMVTALIQGNRVKCHQYWPDEAATKYGDVIVRPLSQEENKVYIKRVFQLQ------KDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYT
.   |||.| |.  .|.||.||||..  ..|||. |. || |... |..|.....      .|||.|.. .| ..||||||.|||. .....  .||.. 
nvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkal

GlKNKHPIVVHCSAGVGRTGTFIALDRLFRAVDHAdlENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYM
  ....|.|||||||||||||||||| |.. ...   . .||  .|. .|. | .||| . ||......| .|.
a.sgggpvvVHCsaGvgRtgtfialdllleqleke..ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 678-940 2.5e-78 258.3 In-house 22-290 (298) alignment 
Range on Protein: 678-940
Range on HMM: 22-290/298.0
TDSGYSGYAEEYEGITEGND----NTSQA--TRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWE
 . . .|||.|.. ......    .....  ...|.  |||... |.|.||| .  .. ....||||| |...|.| . |||||.||. | . ||.|..|
kkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvte

QQAVAIVMVTALIQGNRVKCHQYWPDEAATKYGDVIVRPLSQEENKVYIKRVFQLQKD--GETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGLK
... .|||.| | . ...|.|.||||| ...||.. |. ||.||   .|.| ....|    ..||. |..| .|||.|.|  .  ...... || ..   
edigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqa

NKHPIVVHCSAGVGRTGTFIALDRLFRAVDHAdlENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYM
 ..|..|.|||||||.|||||.| ..  | .   . .||. ||  .|..|. .||.  || .|..   ...
gnkpvivqCsaGvgRsGtfiaidsvlervkke..qvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 678-951 5.9e-47 155.2 In-house 11-288 (307) alignment 
Range on Protein: 678-951
Range on HMM: 11-288/307.0
TDSGYSGYAEEYEGITEGNDN--TSQATRDNRLLNRYSNVTAYDHSRVKVapTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAV
 | | .   .|.. ... . .  | .| . |   |||..| . |..|. |  . .   .||| ||..     || ||..||||  |  ||| |. ...  
ldkgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivv..kfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekve

AIVMVTALIQGNRVKCHQYWPDEAATK--YGD---------VIVRPLSQEENKVYIKRvFQLQKDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRS
...|.  .|.  ..||.|||| |   |  .|.         . .. |. .|. . .   ....  ...| | .... ||||.|.|.  .  |.   ||| 
svimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvtt.lkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry

ytglkNKHPIVVHCSAGVGRTGTFIALDRLFRAVdHADLENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQQLRQVKQAL
     .. |.||||||||||.|| .|.  .   .  |  .  |.. .| ..|  |   .|.  || |.|. | .|.... ..  . |
.....dtnpvvvhcsaGvGrsGtivaislvqdkm.iaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeel
0050432 (Phosphotyrosine protein) phosphatases II 679-942 9.9e-87 286.4 In-house 38-301 (308) alignment 
Range on Protein: 679-942
Range on HMM: 38-301/308.0
DSGYSGYAEEYEGITEGND---NTSQATRDNRLLNRYSNVTAYDHSRVKVaptshNNNTDYINANFVDGY--HGPKEFIATQGPLPVTCVSFWQMIWEQQ
  ..... ||.| ...  .    .. .  .|. .|||... .|||||||.     ....|||||..||||  . |..||||||||| |. .||.|.|||.
aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqn

AVAIVMVTALIQGNRVKCHQYWPDE---AATKYGDVIVRPLSQEENKVYIKRVFQLQK--DGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTgl
   |||.| |.. .|.||.||||.|     ..||.. |. ||.|... |..|...|..  |||.|.. .| ..||||||.|.|. .....  .||..   
vrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..

kNKHPIVVHCSAGVGRTGTFIALDRLFRAVDHAdlENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQ
 ...|||||||||||||||||||| |.. ...    ..||  .|. .|. | .||| . ||......| .|.. 
.pggpivVHCsaGvGRtGtfialdllleqleke..ggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 679-943 4.3e-82 270.4 In-house 17-282 (288) alignment 
Range on Protein: 679-943
Range on HMM: 17-282/288.0
DSGYSGYAEEYEGIT--EGNDN-TSQATRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAV
 .. .|. |||. ..  | ... |      |   ||| |. .||. |||.    .....|||||...||... |..|||||||. |   ||....|... 
arnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

AIVMVTALIQGNRVKCHQYWPDEAA-TKYGDVIVRPLSQEENKVYIKRVFQLQKDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSyTGLKNKHPI
 |||.|.|..|.. ||..||||.   ..||.| |  ....| . ...| . |.|... .|| |...| ||||| |.|.....|... |   .  ..  ||
tivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkv.anqadtgpi

VVHCSAGVGRTGTFIALDRLFRAVDHadLENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQQ
.||||||||||||||||| |  ||..   . .|| ..||..|..|...|| | |||.|...| . . ..
ivhCsaGvGrtgtFialdalidavee..edyiDvagtvaklRkqRallvqtlkqYefiyevllslieed
subfamily_PTPN9_pd Subfamily PTPN9 679-942 3.8e-76 250.9 In-house 12-292 (297) alignment 
Range on Protein: 679-942
Range on HMM: 12-292/297.0
DSGYSGYAEEYEGITEGNDN---TSQATRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAV
. | .|  .||. | . . .   . . .| |   |||..|  ||..||..| .......|||||||||||. .| ||||||||. |.  ||.|.|||...
ekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevl

AIVMVTALIQGNRVKCHQYWP--DEAATKYGDVIVRPLSQEENKVYIKRVFQLQ--KDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGL---
 |||.| ...  |.|| ||||  .|.....||. |. ...||.. | .||....  |..|.|..  | || |||.| |.|...... . .||.. .|   
vivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavk

---------KNKHPIVVHCSAGVGRTGTFIALDRLFRAVDHadLENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQ
          .. |||||||||.|||||||.||     ...  ....||. .|  .|  |. ..|   |||. .... .| ..
elgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrlee..vgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 680-941 4.9e-58 191.4 In-house 17-279 (287) alignment 
Range on Protein: 680-941
Range on HMM: 17-279/287.0
SGYSGYAEEYEGITE---GND-NTSQATRDNRLLNRYSNVTAYDHSRVKVAptshNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAV
 |  |. . .  . .    .|  | . . .|. .||....  .|  || .     ... ||||| |.|||.  |.||....|.  | . ||..|....  
kgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvt

AIVMVTALIQGNRVKCHQYWPDEAATKYGDVIVRPLSQEENKVYIKRVFQLQK---DGETREIAQFEFLNWPDHG-APDSTMDMIEYRTAVRSYTgLKNK
||||.. . . .. .|.||||.|... .|.  .. |..| |. ||.| .....   .|..... |... ||...|  ..    ..     ...    . .
aivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqr.krgn

HPIVVHCSAGVGRTGTFIALDRlfrAVDHADLE-NLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMM
 .||||||..|||...|.| .    ...... |  .||  |. ..|  .  .||.  ||..| . .  |. 
tsivvhCsdtvGrsamfcaaat...tinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_PTPRG_pd Subfamily PTPRG 681-948 1.8e-73 242.7 In-house 17-295 (563) alignment 
Range on Protein: 681-948
Range on HMM: 17-295/563.0
GYSGYAEEYEGIT-----EGNDNTSQATRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNT-DYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQA
|  |..||.| ..     .  | ..   ..|.  |||.|..|||.||||..|.. .... ||||||..|||.  |.||||||||. |.  ||.|||||..
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnv

VAIVMVTALIQGNRVKCHQYWPDEAATKYGDVIVRPLSQEENKVYIKRVFQLQK----D----GETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVrSYT
  |||.| | . .| ||..||| . . .|| . |.  ..|   .| .| .....    .     . ... |... .|||||.|....  . .     |..
aiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks.saa

GLKNKHPIVVHCSAGVGRTGTFIALDRLFRAVDHAdlENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQQLRQVK
  ..  |||||||||||||||.|.|| | . . .   .  .|  ..  .|  | ..||   || ..|..| . .. .  ...
nkaeaGPivvHcsaGvgrtGtyivldtllkqiqqe..navnvfgflkhiraqRnflvqteEqYiflhdalleaiasketell
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 681-941 8.7e-61 200.3 In-house 18-284 (290) alignment 
Range on Protein: 681-941
Range on HMM: 18-284/290.0
GYSGYAEEYEGITEGND---NTSQATRDNRLLNRYSNVTAYDHSRVKVAPTSHNNN--TDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAV
| .|. .... .  |.     | . | .|.||||..|.  ||  |. . | | ...   .|||| ...||.  |..||||||.. | | ||..||...  
gnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvt

AIVMVTALIQGNRVKCHQYWPDEAATKYGDVIVRPLSQEENKVYIKRVFQLQKDG---ETREIAQFEFLNWPDHG---APDSTMDMIEYRTAVRSYTGlk
.|||.|  |. ..|||.|||||. ...|| . .. |..|. . ||.| ......    ..... |... ||...|   .| . . .|| ..  .  .|  
iivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg..

nKHPIVVHCSAGVGRTGTFIALDRlfrAVDHADLE-NLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMM
 ...||||||..|||...|.|..    .....  |   || .|. ..|  .  .||.  ||..|.. .  |. 
.ntsivvHCSdtvgrsavfcaaat...tinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_PTPRD_pd Subfamily PTPRD 683-948 2.4e-97 321.9 In-house 23-289 (564) alignment 
Range on Protein: 683-948
Range on HMM: 23-289/564.0
SGYAEEYEGITEGNDNTSQATR--DNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMV
    |||. |.||.  | .| .   |.  |||.|..|||||||.  ..  ....|||||.|.|||. .|..|||||||. |.  ||.|.|||.   |||.
lkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVml

TALIQGNRVKCHQYWPDEAATKYGDVIVRPLSQEENKVYIKRVFQL--QKDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTgLKNKHPIVVHC
| |   ..||||.|||..  ..||...| . ..|| . |. | |.|  .|. |.||. || | .|||||.|.|. .... .. ||...  ....||||||
tkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhC

SAGVGRTGTFIALDRLFRAVDHadLENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQQLRQVK
|||||||||||..| . . . .   ...|.. .|...|. | .|||   || .||... ...  .  .|.
SaGVGRTGtfividamlerike..ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnteve
subfamily_PTPRB_pd Subfamily PTPRB 683-943 8.9e-94 308.8 In-house 25-288 (293) alignment 
Range on Protein: 683-943
Range on HMM: 25-288/293.0
SGYAEEYEGITE---GNDNTSQATRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVM
 ...|||| . .    .  ..  .  ||  |||.|. .|||||||.|........||||||...||. |.|||||||||| |   ||.|.||... .|||
lrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivm

VTALIQGNRVKCHQYWPDE-AATKYGDVIVRPLSQEENKVYIKRVFQLQKDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYT-GLKNKHPIVVH
.|.|. . .|||..|||..  .. |||. |  ...|| . .. | ....|. |.|.. |..|. ||||| |..|  ....  .||...   ..|.|||||
ltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvh

CSAGVGRTGTFIALDRLFRAVDHADLenLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQQ
|||||||||||||||||..|... |.  .|. ..||..|..|...||.  || .||... |.....
CsaGvGRtGtfialdrllqaieeedy..vdifgivaelReeRnllvqtekqYifihqcvldllrkk
0047943 (Phosphotyrosine protein) phosphatases II 683-940 5.6e-81 267.3 In-house 12-272 (273) alignment 
Range on Protein: 683-940
Range on HMM: 12-272/273.0
SGYAEEYEGITEGN---DNTSQATRDNRLLNRYSNVTAYDHSRVKVaptsHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVM
....||.| ...     . .  .  .|. .|||... .|||||||.    .....|||||..||||. ...||||||||| |. .||.|.|||..  |||
tllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVm

VTALIQGNRVKCHQYWPDEA---ATKYGDVIVRPLSQEENKVYIKRVFQLQK--DGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGLK-NKHP
.| |.. .|.||.||||.|     ..||...|. ||.|... |..|...|..  .||.|.. .| ...|||||.|.|. ...|.  .||..     ...|
LtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngp

IVVHCSAGVGRTGTFIALDRLFRAVDHAdlENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYM
.|||||||||||||||||| |.. . .    ..||  .|. .|  | .||| . ||......| .|.
vvVHCsaGvgRtgtfialdllldqleke..ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Ptp69D_pd Subfamily Ptp69D 683-942 9.8e-78 256.4 In-house 22-288 (307) alignment 
Range on Protein: 683-942
Range on HMM: 22-288/307.0
SGYAEEYEGIT--EGNDNTSQA-TRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVM
 |.|.||| .   | . .|. .   .| | ||| ...|.|. |||....  ....|||||.|. ||.  |.||| |.|.  |   ||.||.||.   |||
fglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivm

VTALIQGNRVKCHQYWPDEAATKYGDVIVRPLSQEENKVYIKRVFQLQKDG-------ETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGLKnKH
.. | . || ||..|||.|  ..|||..|.. |.|. . ||.| ... | .       ..|.. |.....|.|  .|...  .... . ||.   |. . 
lsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rs

PIVVHCSAGVGRTGTFIALDRLFRAVDHADleNLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQ
||||||||||||.|.|.||| |.  .   |  ..|. ..| ..|. |...|| | ||..... | ||.. 
PivvhCsaGvgrsgifvaldsllqqlkaed..kvdifetvkdLrsqRnllvqsleqYvflyralldyssy
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 683-941 1e-69 230.0 In-house 22-284 (305) alignment 
Range on Protein: 683-941
Range on HMM: 22-284/305.0
SGYAEEYEGITEGNDN-TSQATRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVT
.|. ..|. ..| ..    . .  |.  ||....| .|..|............|||||..||||.. |..|..||||. | . ||..|.| . . |||.|
kgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmlt

ALIQGNRVKCHQYWPDEAAT--KYGDVIVRPLSQEENKVYIKRVFQLQK---DGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGLKNKHPIVV
 |..|.. ||.||||.. .   ..|...|   |... . ||.| ... .   | |.| . |... .||||| |...  ...    |.      .. |..|
klveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllV

HCSAGVGRTGTFIALDRLFRAVDHAdlENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMM
||||||||||.|||.|  .  . .   | .||  |. ..|..|  ||| | || ..|  |.... 
hCsagvgRtGvfiavdialerlkkE..evvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 683-948 2.9e-54 179.4 In-house 23-296 (325) alignment 
Range on Protein: 683-948
Range on HMM: 23-296/325.0
SGYAEEYEGIT--EGNDNTSQATRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQaVAIVMV
 |.| |.. .   .|   .  .  .|.  ||. || |.|.||| .    .. ..|||||...  . . . |.|.| ||. |   .|... . .  ..|.|
dgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvv

TALIQGNRVKCHQYWPDE--AATKYGDVIVRPLSQEENKVYIKRVFQLQ--KDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSY-----TGLKNK
.  ....  .| .|||.|   . ..| . |.  . ||   |..||....  |.|||| . ||..  |.| | .     .| .   |        .  |  
lneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkas

HPIVVHCSAGVGRTGTFIALDRLFRAVdhADLENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQQLRQVK
 ||.|||||||||||.||.|  .   |   .  ..|.  .| ..|. |  ||..  ||  |...| ...|    .| 
tpilvhcsaGvGrtGvfislysalakv..ieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvp
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 684-941 2.1e-48 159.6 In-house 16-294 (301) alignment 
Range on Protein: 684-941
Range on HMM: 16-294/301.0
GYAEEYEGITEGNDNTS--QATRDNRLLNRYSNVTAYDHSRVKVAPTSH--NNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVM
...|.|. ..||.|...  . . .|. |||. |.| ||. |. ..|...    ...||||...|||   |.|||.|||.  | | ||..||... |.|||
kfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivm

VTALIQGNRVKCHQYWPDEAAT--KYGDV-------------IVRPLS----QEENKVYIKRVFQLQKDGETREIAQFEFLNWPDHGA-PDSTMDMIEYR
|| | .| . ||.||||.  |.  ..| .             ..| |.    .  |. ||.| |. ..| ..... |..  .||..|  ..  . .    
vtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqvid

TAVrSYTGLKNKHPIVVHCSAGVGRTGTFIALDRlfrAVDHADLEN-LDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMM
  .   .   .. |.|||||..|.|.|......    ... .  |   ||  |.  .|.|.  .|. | ||  |.. .. |..
dvi.hrqqkigggpvvVHCSdtVsrsGvYcsvsi...glEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 684-943 2.5e-34 113.4 In-house 23-290 (305) alignment 
Range on Protein: 684-943
Range on HMM: 23-290/305.0
GYAEEYEGITEGNDNT-SQATR--DNRLLNRYSNVTAYDHSRVKVAPTshnNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMV
|  .|. ..   ||    .| .  ...  ||| .|   |. |||. ..      .|| ||.|     || || || ||  ||  || | ....  || |.
glraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegp...wpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifml

TALIQGNRVKCHQYWPDEAAT------KYGDVIVRPLSQE------ENKVY-IKRVFQLQKDG-ETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSyt
  |..    ||..|.. .         |   ..|.  | .      . |    . |. ..  | ..| .... . .||| | | . . ..|  .  |.  
cnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarp..

glkNKHPIVVHCSAGVGRTGTFIALDRLFRAVDHADLENlDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQQ
    | |||||||||.||||. . |. ..  .   .  . |   ..  .|  |   .|.  || ..|. . .|. ..
...skgpivvhcsagigrtgsvvmleyildqllagqiie.dtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 684-947 2.5e-33 109.9 In-house 28-297 (310) alignment 
Range on Protein: 684-947
Range on HMM: 28-297/310.0
GYAEEYEGITEGND--NTSQATRDNRLLNRYSNVTAYDHSRVKVApTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVT
| . .|  .   .|   | .| ...   ||||.|   | ||||.    .    ||| ||.|   .  . || .||||  | . ||.||....| .|... 
glvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllc

ALIQGNRVKCHQYWPDEAAT-KYGDVIVRPLSQEENKVYIKRV---FQ---LQKD-----GETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGlk
   .  | ||  |||    |  || . |  ||.  ..  |  .   |    .  |      .   ..   . |||| | ||     .  |   .   |  
kvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhg..

nkhPIVVHCSAGVGRTGTFIALDRLFRAVDHADleNLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQQLRQV
   | |||||||..|... .||.  .  .|. .  ..|.  |......||.. .|.  || .|..    .   .  . 
...pcvvhcsagkdrlyvvvalklkidkldrgl..kvdaeevktellksraiciqtelqyliidrvriifargeteva
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 685-745 2e-07 24.7 In-house 24-86 (440) alignment 
Range on Protein: 685-745
Range on HMM: 24-86/440.0
YAEEYEGITEGNDNTSQATR--DNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGY
. .|.  .  |  . |. .   .|.. ||| |. ||||||| .       ..||||| ...| 
fedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
0036941 (Phosphotyrosine protein) phosphatases II 687-941 1.2e-80 266.3 In-house 17-278 (297) alignment 
Range on Protein: 687-941
Range on HMM: 17-278/297.0
EEYEGITEGN---DNTSQATRDNRLLNRYSNVTAYDHSRVKVaptsHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTAL
.|.| ...     . . ..  .|. .|||... .|||.|||.    .....|||||..||||. ...||||||||| |. .||.|.|||.   |||.| |
kefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltel

IQGNRVKCHQYWPDE--AATKYGDVIVRPLSQEE--NKVYIKRVFQLQK--DGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGLK-NKHPIVV
.. .|.||.||||.|     .|||..|. || |.  .. |. |......  .||.|.. .| ...|||||.|.|. .....  .||..  |  ...|..|
velgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlV

HCSAGVGRTGTFIALDRLFRAVDHA-DLENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMM
||||||||.|||||.| ... ...    ...|.  .|  .|. | ..|| | ||.... .| .. .
HCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 687-946 3e-39 129.6 In-house 10-265 (267) alignment 
Range on Protein: 687-946
Range on HMM: 10-265/267.0
EEYEGITEGNDNTSQ----ATRDNRLLNRYSNVTAYDHSRVKVAPTSHNnntdYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTA
.|.| |..  |..|.     . .|.  ||. ..  ||..|| .  . ..    |||| .|.||.  . ||.||.||  |   |...| .|.   ||..| 
kefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk

LIQGNrvkCHQYWPDE--AATKYGDVIVR-PLSQEENKVYIKRVFQLQKDGETREIAQFEFLNWPDHGAPDSTMDMIeyrTAVRSYTGLKN-KHPIVVHC
  ..|    ...|| .   | || |. |   | .|||   |  .    |.  ..... . . .|         .  .    .. .   |.|  .|.||.|
vftdn...irlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkpl...fgilaknqlengnrPlvvac

SAGVGRTGTFIALDRLFRAVDHADleNLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQQLRQ
|.||||.|||. .|  .. . . .   .|.   . ..|. |  .|... .| |||..| .|   .|..
sdGvGrsGtflvidsqlerakteg..vsdifdflrkirsqriglvdtkeryiyihellaeyaegrlke
subfamily_PTPN13_pd Subfamily PTPN13 688-936 9.7e-62 203.7 In-house 16-265 (273) alignment 
Range on Protein: 688-936
Range on HMM: 16-265/273.0
EYEGITE--GNDNTSQAT-RDNRLLNRYSNVTAYDHSRVKVAPTSHnnntdYINANFVDGYHGPKE--FIATQGPLPVTCVSFWQMIWEQQAVAIVMVTA
|.. . |    |.....  ..|.  ||| ||  ||..|||.   .      ||||...    | .|  .||.||||| |.  ||||.|||.|  |.||| 
efkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtl

LIQGNRVKCHQYWPDEAATK---YGDVIVRPLSQEENKVYIKRVFQLQ--KDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGlkNKHPIVVH
  ....||||.|||...  |   .. . |. | ... . .  | ....  . ||.||.|...| .||||| | |....... . ||.     .. |||||
ekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvh

CSAGVGRTGTFIALDRLFRAVDHADleNLDVRAVVANMRHSRTMMVQALPQYEYIHKTL
||||.||.||.|..| ..  ...    ..||. .| ..|. |  .||.  || ...|..
csaGiGrsGtlitidvvlglierdk..efdvkeivrklreqrqgvvqtkdqyifvykai
DSPc_SM00195 689-941 4.9e-79 260.7 In-house 9-263 (263) alignment 
Range on Protein: 689-941
Range on HMM: 9-263/263.0
YEGITEGNDNTSQATRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNR
.|  |. .. |...   |.  |||.|.  |||.|||. .. .....||||||...|.. .|..|||||||| |. .||.|.||..   |||.|   . ..
leestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengk

VKCHQYWPDE--AATKYGDVIVRPLSQEENK-VYIKRVFQLQKDG--ETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGLKnKHPIVVHCSAGVG
 ||..|||.|    ...|.. |   ..|. |  .|.|...|.|.|  |||.. |... ||||||.||||....|.  ||.. .  . ..|||||||||||
ekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvg

RTGTFIALDRLFRAVDHADLenLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMM
|||||...| . . ... .   .|. ..| ..|..| .||| | || .|.... .|..
Rtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtleqYlfiyeaileyik
PTPc_SM00194 689-941 4.9e-79 260.7 In-house 9-263 (263) alignment 
Range on Protein: 689-941
Range on HMM: 9-263/263.0
YEGITEGNDNTSQATRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNR
.|  |. .. |...   |.  |||.|.  |||.|||. .. .....||||||...|.. .|..|||||||| |. .||.|.||..   |||.|   . ..
leestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengk

VKCHQYWPDE--AATKYGDVIVRPLSQEENK-VYIKRVFQLQKDG--ETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGLKnKHPIVVHCSAGVG
 ||..|||.|    ...|.. |   ..|. |  .|.|...|.|.|  |||.. |... ||||||.||||....|.  ||.. .  . ..|||||||||||
ekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvg

RTGTFIALDRLFRAVDHADLenLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMM
|||||...| . . ... .   .|. ..| ..|..| .||| | || .|.... .|..
Rtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtleqYlfiyeaileyik
0043336 (Phosphotyrosine protein) phosphatases II 689-939 2.5e-78 258.7 In-house 26-276 (278) alignment 
Range on Protein: 689-939
Range on HMM: 26-276/278.0
YEGITEG--NDNTSQATRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQG
.| ...   .. .  .  .|. .|||... .|||||||. ...  ...|||||..||||. |..||||||||| |.  ||.|.||..   |||.| |   
feellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvel

NRVKCHQYWPdEAATKYGDVIVRPLSQEENKVYIKRVFQLQ--KDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGlKNKHPIVVHCSAGVGR
.||||.|||| .  ..|||. |. |..|... |. |.. .   .|||.|.. .. .|.|||||.|.|. .....  |||..   ....|..|||||||||
grvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgR

TGTFIALDRLFRAVDHADleNLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDY
|||||||..|.. ...    ..|.  .|. .|. | ..|| . ||..... |..|
TGtfialyllleqlekeg..gvdleeavkelreqRpgavqtpsqyrflyealley
0046845 (Phosphotyrosine protein) phosphatases II 691-942 1.8e-83 275.5 In-house 8-276 (284) alignment 
Range on Protein: 691-942
Range on HMM: 8-276/284.0
GITEGN-----DNTSQATRDNRLLNRYSNVTAYDHSRVKVAPTSHN-NNTDYINANFVDGY-----HGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVM
 ..  .     . .  .   |. .|||... .|||||||. ..... ...|||||..||||     . .|.||||||||| |. .||.|.|||..  |||
ellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVm

VTALIQGNRVKCHQYWPDEA-ATKYGDVIVRPLSQEENKVYIKRVFQLQK---DGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGL-KNKHPI
.| |.. .|.||.||||.|    .|||..|. || |... |..|...|..   .||.|.. .| ...|||||.|.|. |..|.  .||..    ....||
ltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpi

VVHCSAGVGRTGTFIALDRLFRAVDHAD-LENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQ
|||||||||||||||||| |.. ... . | ..||  .|. .|  | .||| | ||......| .|.. 
vVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 692-756 1.1e-08 29.1 In-house 34-95 (95) alignment 
Range on Protein: 692-756
Range on HMM: 34-95/95.0
ITEGNDNTSQATRDNRLLNRYSNVTAYDHSRVKVAptsHNNNTDYINANFVDGYHGPKEFIATQG
.| |   |  ..  |   ||. |.  || .|| ..    . ..||||| |||||   . .||.||
mtsgapytvgsseanipknrflnifpydatrvvlt...tkrdsdyinacfvdgyarkncyiaaqg
subfamily_PTPN23_pd Subfamily PTPN23 694-936 5.3e-53 174.7 In-house 31-276 (288) alignment 
Range on Protein: 694-936
Range on HMM: 31-276/288.0
EGNDNTSQATRDNRLLNRYSNVTAYDHSRVKVAptshNNNTDYINANFVDGYH-GPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCH
| ....  . . .   ||. ..  |||.|||.     ... ||||| || .   |  .|||||.||. |   ||.|..||..  |||..   . .. |..
earkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvd

QYWPDE--AATKYGDVIVRPLSQEENKVYIKRVFQLQKDG--ETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRS-YTG--LKNKHPIVVHCSAGVGRT
.||| .  ...|.||. |   |..| . ...||..|.  .  .....   .. .||..|.|.|  .....  .|.| |.    | | |.|||||||||||
rYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRt

GTFIALDRLFRAVdHADLENLDVRAVVANMRHSRTMMVQALPQYEYIHKTL
|.|  .    |.. ...   ||.  ||  .|. |  |||   |..   .  
gvfalvyaavrel.ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 694-953 3.2e-38 126.1 In-house 43-302 (305) alignment 
Range on Protein: 694-953
Range on HMM: 43-302/305.0
EGNDNTSQATRDNRLLNRYSNVTAYDHSRVKVAPTShnnNTDYINANFVDGYHGP-KEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCH
.   |. |..  .   |||..| . |.| ||..  |    .||| ||.|     | | ||..||||  |   || |. ...   |||.   ..  ..|| 
qvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkca

QYWPDEAA---TKYGDVIVRPLSQE-----ENKVYIKrVFQLQK-DGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSytglkNKHPIVVHCSAGVG
||||       .  . ..|  .|       .... |  ...|    ...  . .... .||| | |   .  .|  .|.|       | |||||||||.|
qywpaaqgeklelksgivvenvsgskpmerdaeiqit.llnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg.....skvpivvhcsagig

RTGTFIALDRLFRAVDHADlENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQQLRQVKQALAT
|||| .|.. ..  .     .   .  .|  .|  |.. .|.  || .||. . .|.... ..   || |
rtgtivaieyilekiaenk.pcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekykekyaallt
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 694-951 1.7e-34 114.2 In-house 31-282 (288) alignment 
Range on Protein: 694-951
Range on HMM: 31-282/288.0
EGNDNTSQATRDNRLLNRYSNVTAYDHSRVKVAptshNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQ
|.. .. ..  .|   .|| |.   | .|||.     ..   ||.|| |   . .. .| .| || .|   .|.|. |..   |||.. |..  . |  .
easidiidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksae

YWPDEA--ATKYGDV--IVRPLSQEENKVYIKRVFQLQKDGETRE-IAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYtglknKHPIVVHCSAGVGRTGTF
|.| .   ....| .  .|.   .. .|.    ... .| ||..  . .  .|.|.|.| |.. .  .   . ..|.     ..|||||.|||||||||.
yfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlksl.....qkPivvhssaGvGrtgtl

IALdrLFRAVDHADLENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQQLRQVKQAL
|    |. ..     ..| .| ..|..| .|   .|.  || |.|. ........  .|.. .
ili..lialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkkykvlred
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 694-798 3.9e-06 19.9 In-house 16-87 (169) alignment 
Range on Protein: 694-798
Range on HMM: 16-87/169.0
EGNDNTSQATrDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINAnfvdgyhgpkefiatqgplpvtcvsfwQMIWEQQAVAIVMVtaliqGNRVKCHQ
| |.  .. |  |   || .   |  | |||.    ..  .|||||                           .|||| .|  ||..     |.     .
eynnfmaelt.cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl.....gdtddknn

YWPDE
.||. 
fwpek
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 695-938 3.7e-68 225.2 In-house 50-289 (319) alignment 
Range on Protein: 695-938
Range on HMM: 50-289/319.0
GNDNTSQATRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTaliqgnRVKCHQY
. | |     .|.  ||. |. |.|...||. ..   . .||||| ||.||  .. .||.||||. |   ||.||||... .||..|      . || ||
ladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqy

WPDEAATKYGDVIVRPLSQEENKVYIKRVFQLQKDG---ETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGL-KNKHPIVVHCSAGVGRTGTFIA
|| ..  |..   |.  | || . |. | ..| .||   . |.| || || |||.| ||...|..     ||  |   .....|||||||||||||..|.
wplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyiv

LDRLFRAVDHAdlENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKD
|| |.  ...   . .||  .| ..|  |  .|| | || .|. .| .
ldvlldrmkee..kqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 695-938 2.2e-67 222.6 In-house 14-253 (284) alignment 
Range on Protein: 695-938
Range on HMM: 14-253/284.0
GNDNTSQATRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTaliqgnRVKCHQY
| | |     .|.  ||. .. |.|...||. ..  .. .||||| |. ||  .. .|||||||. |   ||.||||... .||..|      . || ||
gtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqy

WPDEAATKYGDVIVRPLSQEENKVYIKRVFQLQKDG---ETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGL-KNKHPIVVHCSAGVGRTGTFIA
|| ..  |..   |.  | || . |. | ..| .||   . |.| || || |||.| ||...|..     ||  |   .....|||||||||||||..|.
wplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyiv

LDRLFRAVDHAdlENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKD
|| |.  ...   . .||  .| ..|  |. .|| | || .|. .| .
ldvlldrmkee..kqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 695-797 5.7e-06 19.3 In-house 16-85 (169) alignment 
Range on Protein: 695-797
Range on HMM: 16-85/169.0
GNDNTSQATRdNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINAnfvdgyhgpkefiatqgplpvtcvsfwQMIWEQQAVAIVMVtaliqGNRVKCHQY
 |.  .. |  |   || .   |  | |||.     .  .|||||                           .|||| .|  ||..     |.     ..
ynnfmaeltc.netknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl.....Gdtddknnf

WPD
||.
wpe
0039614 (Phosphotyrosine protein) phosphatases II 696-942 2.9e-78 258.7 In-house 46-291 (297) alignment 
Range on Protein: 696-942
Range on HMM: 46-291/297.0
NDNTSQATRDNRLLNRYSNVTAYDHSRVKVAPTSHN-NNTDYINANFVDGYHG-PKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRvKCHQ
 | .  .   |. .|||... .|||||||. |  .  ...|||||..||||.  ...||||||||| |. .||.|.|||.  .|||.| |.  .| ||.|
pdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaq

YWPDEAAtKYGDVIVRPLSQEENKVYIKRVFQLQKDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGLK-NKHPIVVHCSAGVGRTGTFIALD
|||.|   .|||. |. |. |... |. |.. ....||.|.. .| ...|||||.|.|. ...|   .||..     ...|..|||||||||||||||..
ywpeegg.tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaay

RLFRAVDHAdlENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQ
.... ...    ..||  .|. .|  | ..|| . ||..... |... ..
lmleqleke..ggvdvleavkelreqRpgavqtpsqyrflydallellkr
subfamily_PTPRN_pd Subfamily PTPRN 696-936 1.6e-53 176.4 In-house 44-288 (297) alignment 
Range on Protein: 696-936
Range on HMM: 44-288/297.0
NDNTSQATR--DNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGyHGPK--EFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKC
...|.....  .|   ||...| .|||||||.  .. ....||||| ..   | |.   .|||||||. |  .||||.||| .| ||..| | . .  .|
epstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaild.hdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqc

HQYWPDEAATKYGDVIVRPLSQEE-NKVYIKRVFQLQ--KDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAV-RSYTGlkNKHPIVVHCSAGVGRTGT
..||||| .  |.   |. .|.    . |. | | |.  .  ||| ..|| || ||..|.| |.  ..|.|  | .|| |     |||||||.|.||||.
krywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG..rscpivvhcsdGaGrtGv

FIALDRLFRAVDHaDLENLDVRAVVANMRHSRTMMVQALPQYEYIHKTL
.|..| .   . .  . ..|. | .  .|  |. .|..  |.|.. ...
yilidlvlnrllk.Gvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_CG7180_pd Subfamily CG7180 696-943 1.2e-51 170.2 In-house 32-293 (296) alignment 
Range on Protein: 696-943
Range on HMM: 32-293/296.0
NDNTSQATRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRvKCHQYW
.|   .   .||  ||. .|  ||. || .     ....||||| .||..  .||.| |..|   |  .||........ |.|..|   . .. ....||
gdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsyw

PDEAATKYGDVIVRPLSQEENKVYIKRVFQLQKD------------GETREIAQFEFLNWPD-HGAPDSTMDMIEYRTAVRSYTGLK----NKHPIVVHC
| .. ..||...|  .....     .| |.|.|              ||| . .|..  |.  .  | ||  .|| |  ||.. .      .. |.||..
pnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvs

SAGVGRTGTFIALDRLFRAVDHAdlENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQQ
| |..|.| ..|.|     |..   |..||   |  .|.||  .|.   .| ||  .|..... .
sdGasRsGvylaidanlelveke..eevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn
subfamily_ptpA1_pd Subfamily ptpA1 696-901 3.6e-41 136.3 In-house 36-259 (418) alignment 
Range on Protein: 696-901
Range on HMM: 36-259/418.0
NDNTSQA-TRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHgPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQY
  .||.   . |   |||.|.   .|.||..     .. .||||||..|| . ||.||.|||||| |   ||.|.||...  |||..   .  |.|| .|
psetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdry

WPDEAA----TKYGD---------VIVRPLSQEENKVYIKRVFQLQKDGETREIAQFEFLNWPDHGAPDSTMDMieyRTAVRSYTGL--------KNKHP
||..      . ||.         | .  . |. ..  | |  .|  .||||.|.|...  ||||  || |  .   |  ..| |            . |
wpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpf...rqllhsitnrqnqiipssdrnvp

IVVHCSAGVGRTGTFIALDRLFRAVDHA
|.||||||||||||| .   ... .|| 
iivhcsagvgrtgtfctavimmkkldhy
0040438 (Phosphotyrosine protein) phosphatases II 697-942 1.5e-79 262.9 In-house 34-278 (317) alignment 
Range on Protein: 697-942
Range on HMM: 34-278/317.0
DNTSQATRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWP
. .  .  .|. .|||...  |||||||. |..  ...|||||..|||.. ...||||||||| |. .||.|.|||.   |||.| | . .|.||.||||
tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwp

DEAATKYGDVIVRPLSQEENKVYIKRVFQLQ--KDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGlKNKHPIVVHCSAGVGRTGTFIALDRL
..  ..|||..|. || ||.. .. |.....  .|.|.|.. .| ...|||||.|.|. ....   |||..   ....|..|||||||||||||||....
lgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylm

FRAVDHADleNLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQ
.. ...    ..||  .|. .|. | ..|| . ||..... | .|.. 
leqlekeg..gvdveeavkelreqRpgavqtpeqyrflydalleylkr
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 697-941 2.5e-61 202.2 In-house 35-278 (315) alignment 
Range on Protein: 697-941
Range on HMM: 35-278/315.0
DNTSQATRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWP
 ...  ...|   ||| |.  .|..|||.     . . ||||| .. ...  | .||.||||. .   ||.|...... .||||| . .|...|| ||||
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

D--EAATKYGDVIVRPLSQEENKVYIKRVFQLQKDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYtGLKNKHPIVVHCSAGVGRTGTFIALDRL
|    ....| . |  || | .   ..| . ..|  |.| ..||.| .|||.|..  |  ....  .|..    |......||||||||||| .|..|  
drkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidev

FRAVDHadLENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMM
   . .   . .||  .| |.|  |  .||.  .| .|. .......
vaqikr..trsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 697-936 2.4e-53 175.9 In-house 24-262 (283) alignment 
Range on Protein: 697-936
Range on HMM: 24-262/283.0
DNTSQATRDNRLLNRYSNVTAYDHSRVKVAPTSHnnntDYINANFVD---GYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQ
| . .....|.  ||. .. ..|  ||.. . |.    ||||| |.     |.  |..|..|.||  | | ||.|.......||||.| | ...|.|| |
dadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsq

YWPDEAATKYGDVIVRPLSQEENKVYIKRVFQLQKD---GETREIAQFEFLNWPDHGAPDSTMDMIEYRtAVRSYTGLKNKHPIVVHCSAGVGRTGTFIA
||| . . .||.  |    .  .. .|.. . |...    .|  .| . . .| . |       .. .   |.|    ..| |||||||.|.|||..|||
yWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfn.kvislqteskkgPivvhCstgiGrtavfia

LDrlfRAVDHADLEN-LDVRAVVANMRHSRTMMVQALPQYEYIHKTL
.     .|..|  |  .|| ||| .||  | |.||.| ||  .|.  
as...asvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 697-938 6.2e-44 145.0 In-house 36-234 (392) alignment 
Range on Protein: 697-938
Range on HMM: 36-234/392.0
DNTSQATRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNrvkchqywp
..|.  . .|   ||| |.  || .|||.      ...||.|| ......  | .||.||| . .   ||.|...... .|.||| | .|.         
pqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........

deaatkygdvivrplsqeenkvyikrvfqlqKDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGlKNKHPIVVHCSAGVGRTGTFIALDRLfr
                               |  ..| .||| | .|||.. |  |  ....   |..  | .  ||...||||||||||  |..| .  
...............................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfG.qythpliihcsagvgrtgvvisidsv..

aVDHAD-LENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKD
 | ||     .||  .|.|.|. | .|||.  || .|. .. .
.vahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 697-864 1.6e-34 114.2 In-house 23-195 (297) alignment 
Range on Protein: 697-864
Range on HMM: 23-195/297.0
DNTSQATRDNR-LLNRYSNVTAYDHSRVKVAPTshNNNTDYINANFVDGYHG--PKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQ
.. | | |..    ||| .. |.| .|||.  .    ..|||||..|   .   .  .| .||||  |   ||....||.  .||||. | .. | ||  
esfssakrnsslrknryrdilatddtrvkllrv..iterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcap

YWPD--EAATKYGDVIVRPLSQE---ENKVYIkRVFQLQKDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRS
|||.  .   | |||.|  ||.     ..|..   .||    |.| .   .||.||||| |    |.  ... | |
ywpsvvqerlkagdvvveflsstsdefdrvil.telqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcs
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 699-941 8e-30 98.8 In-house 28-271 (285) alignment 
Range on Protein: 699-941
Range on HMM: 28-271/285.0
TSQATRDNRLLNRYSNVTAYDHSRVKVaptsHNNNTDYINANFVDGY-HGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPD
|  |   |  ||||..| . . .|| .    .| . ||| |...    .    .|.|||||| |   ||.||....   ..|. .|..|   ||  |.|.
tytayeanpdlnryadvrcieetrvvl....knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype

EA--ATKYGDVIVRPLSQEENKV--YIKRVFQ-LQKDG---ETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGlkNKHPIVVHCSAGVGRTGTFI
.     |.|   .     .|. .   |   .  .. .    |   . . .   |||. ||. .  |||    |.      ...||.|||||||||| ||.
klgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp..kekpicvhcsagvgrtatfv

ALDRL-FRAVDHADLENLDvraVVANMRHSRTMMVQALPQYEYIHKTLKDYMM
 .|    | ..  ..| ||   .| .||  |   ||.  |. ...  | .|..
gidyatirimenpniemld...ivremramrfqavqshmqflflyvvlmeyfi
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 699-781 1.1e-07 25.7 In-house 30-117 (347) alignment 
Range on Protein: 699-781
Range on HMM: 30-117/347.0
TSQATRDNRLLNRYSNVTAYDHSRVKVAPTSH-NNNT----DYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVT
||.    .   ||  .|   | .|| ..|    |...     ||||  .      ||.| || ||| |   ||.|.   .   .| . 
tsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_PTPN1_pd Subfamily PTPN1 700-932 2e-61 202.2 In-house 26-263 (290) alignment 
Range on Protein: 700-932
Range on HMM: 26-263/290.0
SQATRDNRLLNRYSNVTAYDHSRVKVaptsHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDE-
.  .  || |||| .|. |||||.|.    .....|||||..|.  .  ...| |||||| |.  ||||.|||.. |.||.  ... ...||.|||| . 
eaklpenrnlnryrdvspydhsrikl....eradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqge

--AATKYG--DVIVRPLSQEENKVYIKRVFQLQK--DGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGLKNKH-PIVVHCSAGVGRTGTFIAL
   . ..    . |. .|.|... |. |...|..    ||||| .| .. ||| | |.|   ....   ||.   |.... | |.|||||.||.|||. .
eekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclv

DRLFRAVDHAD-LENLDVRAVVANMRHSRTMMVQALPQYEYI
| ..  ... | |...|.. |. ..|. |. ..|.  | .. 
dtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfs
0040439 (Phosphotyrosine protein) phosphatases II 701-941 2.3e-73 242.2 In-house 6-247 (249) alignment 
Range on Protein: 701-941
Range on HMM: 6-247/249.0
QATRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEAA
     |. .|||... .|||||||. ...  . .|||||...|||. ...||||||||| |. .||.|.||..  .|||.| | . .|.||.||||..  
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggs

TKYGDVIVRPLSQEENKVYIKRVFQLQ--KDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGLK-NKHPIVVHCSAGVGRTGTFIALDRLFRA
..|||. |. || |... |. |...|.  .|||.|.. .. ...|||||.|.|. |....  |||..     ...|..|||||||||||||||.. ... 
leygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleq

VDHAdlENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMM
...    ..|.  .|. .|. | ..|| . ||..... |... .
leke..lgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 701-937 2e-55 183.0 In-house 43-276 (439) alignment 
Range on Protein: 701-937
Range on HMM: 43-276/439.0
QATRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRvkchqYWPDEAA
 |   ..  ||| .|.|.||.|| .  .     . |||||...||. .| .||||||   |. .||....|...| |||.| |..  .     ||| .| 
aaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdae

TKYGDVIVRPLSQEENKVYIKRVFQLQKDG----ETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGLKNKHPIVVHCSAGVGRTGTFIALDRlfr
. |||..||   . |   |. | |.. ..       | . || .. |||.  |  .  ....  |. |    ..  |.||||||||||||| ||||    
vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdi...

AVDHADLEN-LDVRAVVANMRHSRTMMVQALPQYEYIHKTLK
|...  ||| .|.. .|  .|. |. ||||| || .|.... 
aleqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavl
0045098 (Phosphotyrosine protein) phosphatases II 702-941 2.1e-74 245.7 In-house 29-273 (278) alignment 
Range on Protein: 702-941
Range on HMM: 29-273/278.0
ATRDNRLLNRYSNVTAYDHSRVKvaptshnnntDYINANFVDGYhgPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEAAT
  ..|. .|||... .|||||||          |||||...|||  ||.||||||||| |. .||.|.||..  .|||.| |....|.||.||||..   
lylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsl

KYGDVIVRPLSQEENKVYIKRVFQLQ------KDGETREIAQFEFLNWPDHGAPDST--MDMIEYRTAVRSYTG------------LKNKHPIVVHCSAG
 |||. |. || |... |..|.. ..      .|.|.|.. .. .|.|||||.|...  . ..|.   .|..              | ...|..||||||
tygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaG

VGRTGTFIALDRLFRAVdhaDlENLDVRAVVANMRHSRTM-MVQALPQYEYIHKTLKDYMM
||||||..|.. . . .   . ...|.  .|. .|  | . .|| | ||..... | .. .
vgRtGtlvaaylmlell...e.ggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPN12_pd Subfamily PTPN12 702-949 1.1e-73 242.7 In-house 36-286 (290) alignment 
Range on Protein: 702-949
Range on HMM: 36-286/290.0
ATRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDE--A
 .  |.  ||| ..  ||.|||..  ...... |||||||. | .|..|.||.||||| |   ||.||||..   .||.  ..  .. ||..|||.|   
ekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegee

ATKYGDVIVRPLSQEENK-VYIKRVFQLQKDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGlKNKHPIVVHCSAGVGRTGTFIALDRLFRAV
....|.. |   ...  .  .. | .......|.|.. ||.. .||||| | |. ...|  ..||..   ....|.||||||||||||| ||.|   ...
elefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrell

DHADL-ENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQQLRQVKQ
 .  . |.|||  .|...|. |. .||.  |||...|.. ... ..|.....
kaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiiee
subfamily_PTPRA_pd Subfamily PTPRA 702-941 4.3e-71 234.5 In-house 54-296 (330) alignment 
Range on Protein: 702-941
Range on HMM: 54-296/330.0
ATRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEAAT
.  .|.  ||. |.  ||.||| ... . ....||||| |.|||.  ..|||.|||.  |   ||.|||||.. .|||.| | . .. ||.|||||| . 
skeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlv

KYGDVIVRPLSQEENKVYIKRVFQLQ------KDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGLKNKhPIVVHCSAGVGRTGTFIALDRLF
 ||.. |    ... . |  | | .|      .. ..| ..|| |  ||| | |  .. |...  .|..    .   |||||||||||||||||.|| ..
tyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavl

RAVdHADlENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMM
  | .|. . .||  .| ..|  |. |||.. |||.|.|.|..| .
erv.kae.rkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 702-942 6.7e-34 112.0 In-house 39-278 (312) alignment 
Range on Protein: 702-942
Range on HMM: 39-278/312.0
ATRDNRLLNRYSNVTAYDHSRVKVAptshNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEAA-
|    . |||| |.  .|  |  .|     ..  || ||||     |. |..|||||  ||. |||.     ...|........    || .|  |  . 
aflkfkdlnrypniqcwdrgrftla....gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgf

TKYGDVIVRPLS--------QEENKVyIKRVFQL--QKDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRsytglKNKHPIVVHCSAGVGRTGTFIA
 .  |  |   .        .  .|.  .||...  .  |.   . ....  ||||| |||        .||.     |.|.|.. |||||||||||.. 
vdledhrvyteycteieiggkskdki.thrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk.....kdkkpviahcsagvgrtgtlal

LDRLFRAVDHADLENldVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQ
.. .  |. |   .|  |. .   .|. |.  |...||| |  ... .... 
iesmiaalrhprkqn..vkdsfvllrkdrarsvrvfpqyvyalrcvleflys
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 703-943 3.7e-65 214.7 In-house 25-271 (274) alignment 
Range on Protein: 703-943
Range on HMM: 25-271/274.0
TRDNRLLNRYSNVTAYDHSRVKVAPTS-HNNNTDYINANFVDGYHG-PKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEAA
   .   ||| ..   ..||| . . | ......|||||.. ||..  | ..||||||| |   ||.||.....  |||.| | . |. ||..|.||.  
vfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaed

T----KYGDVIVRPLSQEENKVYIKRVFQLQKDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGLKNKH--PIVVHCSAGVGRTGTFIALDRL
.    .|||| ..  .  |.. |  | . |..  ..|..  . . .|||| .||..  ...  . |..    .|..  |.|||||||.|||| ||| .  
yeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisia

FRAVDHAdlENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQQ
 | ...   . .||  .|.|.|  |  |||.  |||.||..|  |. . 
vrqlree..ivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 703-935 3.2e-53 175.3 In-house 5-236 (239) alignment 
Range on Protein: 703-935
Range on HMM: 5-236/239.0
TRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHG-PKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEaAT
 | |.  |||.|. .|||||| .   | .  .|||||...  | | || .||||| . ...  ||.|.|... . |||.| ||.| . ||||||||  ..
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.ts

KYGDVIVRPLSQEENKVYIKRVFQLQKDGET--REIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSyTGLKNKHPIVVHCSAGVGRTGTFIALDRLFRAVD
|| .. |     |    || | | . . |.|  | . |. |  |||.| |. .  ..  |  .     |   .| |.||||||||||.|. .| ..|   
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqak

HAdlENLDVRAVVANMRHSRTMMVQALPQYEYIHKT
.   . .|.   |  .|  |  |||.  || .|| .
kq..ktvdifnyvkairedrphmvqtseqyvfihla
subfamily_egg_pd Subfamily egg 703-940 2.8e-21 70.5 In-house 37-270 (307) alignment 
Range on Protein: 703-940
Range on HMM: 37-270/307.0
TRDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRvkCHQYWPD----E
. .|.   |   |   | ||||.         |.| || |.|     ||| .| ||  |   ||.|.....   |||.|.  . .|  |. |||      
sdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeser..ceyywpkaesds

AATKYGDVIVRPLSQEENKVYIKRVFQLQKDGETREIAQFEFLNWPDHGAPdstmDMIEYRTAVRSYTglKNKHPIVVHCSAGVGRTGTFIALDRLFRAV
. |  | . .  |  ...   . || .|.  |  .|    |  ..  . .     |.      .|     .  .|.||..  || ...|..|..  .  .
lvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnss....dvysplrvlrklr..nlskpvvvqdilGvskaatlvaieiallsl

DHADLENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYM
    .    |.  |  .|  | . |..  .| .... .  ..
lrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
0042113 (Phosphotyrosine protein) phosphatases II 704-940 9.4e-74 243.2 In-house 7-243 (245) alignment 
Range on Protein: 704-940
Range on HMM: 7-243/245.0
RDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEAATKY
  |. .||||.. .|||.|||. |..... .|||||..||||. .. ||||||||| |.  ||.|.||..  .|||.| .   .||||.||||..  ..|
penkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgeslty

GDVIVRPLSQEENKVYIKRVFQLQ--KDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGLKNKHPIVVHCSAGVGRTGTFIALDRLFRAVDHA
||..|. || | .. |. |.....  .|.|.||. .. .|.|||||.||.. ....   .||..   ....|..|||||||||||||||...... ... 
gdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqleke

dlENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYM
   ....  .|. .|  | ..|| . ||..... |....
..lgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 704-943 5.7e-70 230.4 In-house 18-267 (270) alignment 
Range on Protein: 704-943
Range on HMM: 18-267/270.0
RDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHG-PKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEAAT-
  .. |||| ..    ..||.... .....| |||||.| |..| .|..||..|||| |  |||.||||... ||||.| |   .| || .||| |. . 
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

---KYGDVIVRPLSQEENKVYIKRVFQLQKDGETREIAQFEFLNWPDHGAPDSTM------DMIEYRTAVRSYTGLKNK-HPIVVHCSAGVGRTGTFIAL
   ..|.. |. ||.| .. ||..  .|...||.|..  | . .|||||.| ..       ....   ||| ..  ..| .|..||||||||||||.|||
vkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlial

DRLFRAVDHAdlENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQQ
|  .|....   ...|| |.....|. |. .||   |||...|..  |. ..
DiavrlLeet..kkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_PTPN3_pd Subfamily PTPN3 704-936 6.9e-66 217.0 In-house 39-271 (280) alignment 
Range on Protein: 704-936
Range on HMM: 39-271/280.0
RDNRLLNRYSNVTAYDHSRVKVaptsHNNNTDYINANFVD----GYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEA
 .|   ||| ....||. |||.    ....|||||||.|.    . .  . .|||||||. |.  ||||.|||..  |||.| |..  |||||||||.. 
penlsknryrdilpydatrvkl....kesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPete

-ATKYGDVIVRPLSQEENKVYIKRVFQLQKDG--ETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGLkNKHPIVVHCSAGVGRTGTFIALDRLFR
  ..||.  |.  ...|.| |. | . |..    | |.| |. .|.||||| ||.. |..|. . ||..    ...|.|||||||.|||| .|.|.  . 
deleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg.keePvvvhCsaGigrtGvlilletala

AVDHAdlENLDVRAVVANMRHSRTMMVQALPQYEYIHKTL
 ...|  |.. . ..| .||  |.|.||.  ||... ...
lieaa..epvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 704-943 6.7e-60 197.7 In-house 49-287 (297) alignment 
Range on Protein: 704-943
Range on HMM: 49-287/297.0
RDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGpkEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRvKCHQYWPDEAATKY
. |   .||.|.  || ||||.| . .. . ||.|| || |..   ..|.|| | . |   ||.|....|. .|||.. . .... || .||.|.. |..
kvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttf

GDVIVRPLSQEENKVYIKRVFQLQKDG--ETREIAQFEFLNWPDHGAPD--STMDMIEYRTAVRSYTGLKNKHPIVVHCSAGVGRTGTFIALDRLFRAVD
||| |  || .| . .||| ....|.    .| . |..|..|||.  .   |.  .... . ||   . ... |..|||.||||||| ....|     . 
GdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeak

HAdlENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQQ
.   ...|.  .|  .|..|  .||.  ||....... .... .
re..kevdifglvkklrqerpylvqtkeqykfvyvavleallse
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 704-935 3.5e-53 175.2 In-house 5-235 (239) alignment 
Range on Protein: 704-935
Range on HMM: 5-235/239.0
RDNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHG-PKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEaATK
| |.  |||.|. .|||||| .   | .  .|||||...  | | || .||||| . ...  ||.|.|... . |||.| ||.| . ||||||||  ..|
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tsk

YGDVIVRPLSQEENKVYIKRVFQLQKDGET--REIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSyTGLKNKHPIVVHCSAGVGRTGTFIALDRLFRAVDH
| .. |     |    || | | . . |.|  | . |. |  |||.| |. .  ..  |  .     |   .| |.||||||||||.|. .| ..|   .
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakk

AdlENLDVRAVVANMRHSRTMMVQALPQYEYIHKT
   . .|.   |  .|  |  |||.  || .|| .
q..ktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 705-940 1.1e-70 232.7 In-house 8-242 (250) alignment 
Range on Protein: 705-940
Range on HMM: 8-242/250.0
DNRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVkCHQYWPDEAATKYG
.|.  |||... |.|.||| . ... ....||||| |..||.. | ||||||||. | . ||.|..|... .|||.| | . ... .||||| | |.|||
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyG

DVIVRPLSQEENKVYIKRVFQLQKDGETRE--IAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGLKNKHPIVVHCSAGVGRTGTFIALDRLFRAVDHAd
|| | .||.||   |.||...| |  .. |  . |..|..||| | |. .  ..|... |..     .. |..|.|||||||.|.|||.| ..  . .  
dvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkke.

lENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYM
 . .||. |.  .|. |  .|..| || .... .. ..
.kvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
0037934 (Phosphotyrosine protein) phosphatases II 705-939 2e-67 222.6 In-house 9-241 (243) alignment 
Range on Protein: 705-939
Range on HMM: 9-241/243.0
DNRLLNRYSNVTAYDHSRVKVaptshnNNTDYINANFVDGYhgPKeFIATQGPLPVTCVS----FWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEAa
 |.  ||||.. .|||||||.      ...||||||.....  |. .|||||||| |. .    ||.|.||..  .|||.| |.. .|.||.||||.|  
enlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgev.

tKYGDVIVRPLSQEENKVYIKRVFQLQK---DGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGL-------KNKHPIVVHCSAGVGRTGTFIA
  |||..|. ||.|. . |. |...|.    |..||.. .. .|.|||||.|||. |....  .||..          ....|..||||||||||||.||
.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtlia

LDRLFRAVdhadleNLDVRAVVANMRHSRTM-MVQALPQYEYIHKTLKDY
.. . . .      ..|.  .|. .|  | . .|| . ||..... |. .
aylmllll......gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 705-936 5.1e-57 187.8 In-house 2-235 (237) alignment 
Range on Protein: 705-936
Range on HMM: 2-235/237.0
DNRLLNRYSNVTAYDHSRVKVAPTSHNnnTDYINANFVDGYHG-PKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDE-AATK
.|.. |||.|..||||||| .  .  .  .|||||....|. | ||..||.||||  .|  ||||.|...   |||.| ||.||..|||.|||.    . 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGDVIVRPLSQEENKVYIKRVFQLQKDGE---TREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYT-GLKNKHPIVVHCSAGVGRTGTFIALDRLFRAV
|| . |    .||   |  | . |.| ..    | | |..|  |||.| |. |  .. .|  .   .  . .  | ..|||||||||| |. .| ..|  
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

DHAdlENLDVRAVVANMRHSRTMMVQALPQYEYIHKTL
     . .|.   | ..   |  ..|.  || .||.|.
kek..kvvdiynyvysieedrpyiiqtkdqyvfihqti
0049772 (Phosphotyrosine protein) phosphatases II 705-940 2.7e-43 144.2 In-house 45-280 (314) alignment 
Range on Protein: 705-940
Range on HMM: 45-280/314.0
DNRLLNRYSNVTAYDhSRVKVaPTSHNNNTDYINANFVDGYhgpKEFIATQGPLPVTCVSF----------WQMI--WEQQAVAIVM-------------
 ||  ||| ..  .| .||.. |. .....|||||..|||.   . ||||||||..|.|.|          |.|.  ....   |||             
lnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrL

--------VTALIQGNrvkchqywpD---------EAatkygdvivrplsqeeNKVYIKRVFqlqkdgeTREIAQFEFLNWPDHGAPdSTMDMIEYRTAV
         . |  ..         .                           . .| .  |       .|.. ..  ...||..|| .. |. |   ..
daAlgKtpllildgng.........neptaadlellk................eelydpelf.......erlgikylripvpDgsap.lledfdeflefi

RSYtglKNKHPIVVHCSAGVGRTGTFIALDRLFRAVdhadleNLDVRAVVANMRHSRT-----MMVQALPQYEYIHKTLKDYM
...   ....|..|||.||.||||||.... | ..       ..... ... .|  |.      ... | |||.|.. |..|.
eea...dkggpvlvHCkaGkgRtgtfvvaaylmkll......gvsleealedvrlkRpinpnpgfieqleqyefilealleyl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 705-848 5.1e-12 39.9 In-house 95-235 (244) alignment 
Range on Protein: 705-848
Range on HMM: 95-235/244.0
DNRLLNRYSNVTAYDHSRVKVAPTSHNNNtdYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVtaliqGNRVKCHQYWPDEAA-TKY
.|   || .    .| .|| ..  |  |   |||| ||       |.| || ||  | . ||.|. |.    .|..     |   .  .||||      |
nnswknregaglpfdfnrvplskgsmgnt..yinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvl.....gsveeedeywpdseplewy

GDVIVRPLSQEENKVYIK-RVFQLQKDGE--TREIAQFEFLNWPDHGA
 . |   |.. ..   ||   .... | .   . .. |.  |||  |.
eeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgt
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 706-941 1.9e-61 202.7 In-house 43-277 (515) alignment 
Range on Protein: 706-941
Range on HMM: 43-277/515.0
NRLLNRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPD--EAATKY
|   ||| |.  || .|||.     | . ||.|| .. ...  | .||.|||.. .   ||.......  .|.||| | .|...|| .||||    . |.
nfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkf

GDVIVRPLSQEENKVYIKRVFQLQKDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGLKNkHPIVVHCSAGVGRTGTFIALDRLFRAVDHAdl
| . |  .| |     ||| ... |. ..| ..||.| .|||.|.|  |  .. .  .|.. .|  . ||...|||||||||| .|..|     .  .  
GsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahaktt..

ENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMM
. .||  .| |.|  |  .||.  || .|. .......
rmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
0041856 (Phosphotyrosine protein) phosphatases II 706-944 2.8e-49 162.5 In-house 1-175 (182) alignment 
Range on Protein: 706-944
Range on HMM: 1-175/182.0
NRLLNRYSNVTAYDHSRvkvaptshnnNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTaliqgnrvkCHQYWPdeaatkygd
|. .||||..  |||||          . ||||||...|.. ...||||||||. |. .|..|..|..  .||..|         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

vivrplsqeenkvyikrvfqlqkDGETREIAQFEFLNWPDHGAPDsTMDMIEYRTAVRSytglkNKHPIVVHCSAGVGRTGTFIALDRLFRAvdhadleN
                       . ..|.. |. .|.|||||.|| . .....  .|..     ...|..||||||||||||..|.. . .        .
.......................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.......g

LDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQQL
.... .|. .|  | .||. . || ...  | ...... 
vsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 706-951 6.9e-42 138.0 In-house 37-279 (281) alignment 
Range on Protein: 706-951
Range on HMM: 37-279/281.0
NRLLNRYSNVTAYDHSRVKVAP-TSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEAA--TK
|   |||.|. . | |||..      .| |||| ||..      . .| ||||   |   ||.|||.... ||||.  ... || || .|.| .|    .
nnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclq

YGDVIVRPLSQEENKVYIKRVFQLQKDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSytglkNKHPIVVHCSAGVGRTGTFIALDRLFRAVdHAD
.  . |       ||  .   ..|  .|||| |... . .|||   |.|.  |..    .|.        | |.||||||||.||..|..  .... |. 
fdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira.....rstppvihcsagvgrsgtlmaveialqsi.hsh

LENLDVRAVVANMRH-SRTMMVQALPQYEYIHKTLKDYMMQqLRQVKQAL
.   |.. .|. .|   |.  ||.| ||  | | | |. .   .|. . |
ftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgva.ykqiteel
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 706-942 1.2e-18 61.8 In-house 47-281 (303) alignment 
Range on Protein: 706-942
Range on HMM: 47-281/303.0
NRLLNRYSNVTAYDHSRVKVAPTShnnntdYINANFVDgYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEA-ATKYG
|   ||. .|   |||.||.. .|      || |....  .  |  | || ||. |.  ||||| ||.   .... .  . ...  .  .| .    |. 
nmdknrfvdvicldhskvklsdss......yihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfe

DVIVRPLS--Q-EENKVYIKRVFQLQKDGETREIAQFEFLNWPDHGAPDS-TMDMIEYRTAVRSYTG-LKNKHPIVVHCSAGVGRTGTFIALDRLFRAVd
.  .|     . |  . .  .|  . .      .    . .||    |   .  ..     ..|.     . .| |    .|.||.|||  ..    .. 
ersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlsl.

HADLENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQ
|..   ||.  .. |.|  |   || | |. ...  | .....
hseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvld
Y_phosphatase Protein-tyrosine phosphatase 709-936 5.4e-75 247.2 Pfam-A 4-233 (235) alignment 
Range on Protein: 709-936
Range on HMM: 4-233/235.0
LNRYSNVTAYDHSRVKVapTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWP--DEAATKYGDV
 |||.....||..|||.  .......||||||.|.||. .|.||||||||. |. .||.|.|...  .|||.| | . .|.||.||||  .|  ..|||.
knRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

IVRPL-SQE-ENKVYIKRVFQLQKDGET---REIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTgLKNKHPIVVHCSAGVGRTGTFIALDRLFRAVDHA
 |.   ... ..| |. |...|.|..|    ||. |. . ||||||.|.|. ..... ..|....  ....|.||||||||||||||.||| |.. ... 
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleae

DLenLDVRAVVANMRHSRTMMVQALPQYEYIHKTL
.   .||  .| ..|..| .||| | ||....|..
ee..vdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 709-936 5.4e-75 247.2 In-house 4-233 (235) alignment 
Range on Protein: 709-936
Range on HMM: 4-233/235.0
LNRYSNVTAYDHSRVKVapTSHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWP--DEAATKYGDV
 |||.....||..|||.  .......||||||.|.||. .|.||||||||. |. .||.|.|...  .|||.| | . .|.||.||||  .|  ..|||.
knRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

IVRPL-SQE-ENKVYIKRVFQLQKDGET---REIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTgLKNKHPIVVHCSAGVGRTGTFIALDRLFRAVDHA
 |.   ... ..| |. |...|.|..|    ||. |. . ||||||.|.|. ..... ..|....  ....|.||||||||||||||.||| |.. ... 
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleae

DLenLDVRAVVANMRHSRTMMVQALPQYEYIHKTL
.   .||  .| ..|..| .||| | ||....|..
ee..vdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 709-940 2.6e-49 162.5 In-house 41-277 (287) alignment 
Range on Protein: 709-940
Range on HMM: 41-277/287.0
LNRYSNVTAYDHSRVKVAPTShNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDE-AATKYGDVI
 |||..|  .|..|| .. .. .  .||||||.| .|.  ..|||.|||.. |  .||....|... .....|  ..  | ||..|||.     . |   
knryadvlPiddtrvllsaeg.elGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGys

VRPLSQEENK-VYIKRVFQLQkDGETRE---IAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGLK----NKHPIVVHCSAGVGRTGTFIALDRLFRAVd
|  |...  .  |  | ..|  | ||||   . |...|.|||.... ... .| .   |. .  |.    .  |.|||...|.||.|...|.  | .   
vvlldydikePeygvralrli.dletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrl.

hADLENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYM
  || ..|| |||. .|  |. .|||  |. .. ..|  | 
.edlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 709-939 5.9e-40 131.7 In-house 59-282 (290) alignment 
Range on Protein: 709-939
Range on HMM: 59-282/290.0
LNRYSNVTAYDHSRVKVaptSHNNNTDYINANFVDGYHGPkeFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEA--ATKYGDV
 ||| .|.  | .|| .   .   . ||. ||.|.| . .  || |||.|  | . .|.|. .... ||||.  ||.  . ||.||.|...  .  .|..
knrykdvvcndktrvil...kdGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGei

IVR-PLSQEENKVYIKRVFQL--QKDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGlknkhPIVVHCSAGVGRTGTFIALDRLFRAVdhADL
 |   .......  ||... .  ...|    .  ..   |||.  . ||. ..    ..|  .|     |.|||||||.||||||.|..   . .   | 
tvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasG.....pvvvhcsaGiGrtGtfvaievglqil..ldG

ENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDY
 .||.  .|  .|.||   ||   ||  . . | |.
keldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 709-823 7.1e-21 69.3 In-house 50-175 (350) alignment 
Range on Protein: 709-823
Range on HMM: 50-175/350.0
LNRYSNVTAYDHSRVKVA--P-----TSHN-NNTDYINANFVDGY----HGPKEF--IATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQY
 |||.|.  |.|||||.   .       |  .  ||||||..       .   .|  ||||.||| |   |...| . .   |...|...  |. ||..|
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

WPDeaaTKYGDVIVRPLSQEENKVYIKRV
|..    .| |. |.  |. || . |. .
Wqe...gsydditvklaskwenimginds
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 709-798 2.1e-10 34.4 In-house 51-156 (349) alignment 
Range on Protein: 709-798
Range on HMM: 51-156/349.0
LNRYSNVTAYDHSRVKVAP---------TSHN-----NNTDYINANFVD--GYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCH
 |||...  |.|||||.           .|.         ||||||..    .   | .|||| ||| |   |...|  ..   .. ..   . .  ||.
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

QYWPDE
.|| . 
iywqel
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 710-929 1.1e-29 98.2 In-house 54-270 (301) alignment 
Range on Protein: 710-929
Range on HMM: 54-270/301.0
NRYSNVTAYDHSRVKVAptsHNNNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEAATK--YGDVI
.|| .|    .. |.|     . .   | ||...    |. ||||||||. |.  || |.   .   |||..  .. .  ||..| | . . |   |   
hryptvPckPstavevi...vdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfk

VRPLSQE--ENKVYIKRVFQLQ---KDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRsytglKNKHPIVVHCSAGVGRTGTFIALDRLFRAVDhAD
..  ..|   ||  .|| ....   .. .|| .  . . .|.|.| | | ... .    |.     | ..|||||||||.||. .||. . | |.|. ||
ikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvk.....ksekPivvhcsaGiGrsvafigteylareve.ad

lENLDVRAVVANMRHSRTMMVQALPQY
  ....   ....|. |   ||   | 
.ptieltealkhlrehrwngvqtnsql
subfamily_CG42327_pd Subfamily CG42327 710-861 1.8e-22 74.4 In-house 32-189 (319) alignment 
Range on Protein: 710-861
Range on HMM: 32-189/319.0
NRYSNVTAYDHSRVKVAPTSHNNNTDYINANFVDGYH-GPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEAA----TKYG
.|. ||    ..|| .   . .... |..|..| ||.  |  .||.| .|  .  .||...||||.  || .| | .    .| .|.| ...      ||
srvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyG

DVIVRPLSQEENKVYIKRVFQLQK--DGETREIAQFEFlNWPDHGAPDSTMDMIEYRTA
|. |    .| .. |.   . |..  . |.||.. . . .|.. . | .   .|     
dilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamlle
subfamily_eak_pd Subfamily eak 712-953 5.2e-20 66.1 In-house 57-321 (332) alignment 
Range on Protein: 712-953
Range on HMM: 57-321/332.0
YSNVTAYDHSRVKVAPTSHNnNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEA--ATKYGDVIVR
  ..  ||.  |.....  | .  ||||  ..  .  ...| |  .       ||||. ||.. |||..   .. .  |  .|.||..    |.| . | 
vvkivpydrylvrltssqln.rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildve

PLSQEENKVYIKRVFQLQKDGETREIAQFEFLNWPDHGAPDS--------TM------DMIEYRTAV-----RSYTGLKNKHPIVVHCSAGVGRTGTFIA
  .  .....  | ..|.|  || ..  ...  | .   |          .|       .|  ..|.     . |      .  .. .. |  |.|.|. 
rkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsaraGvfvv

LDRLFRAVDHADLENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQ---QLRQVKQALAT
.| | | .|    .   |  ..  ... |   | .  |. .|.. . ||...   .||..|. | .
idllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrdlkkylea
0044763 (Phosphotyrosine protein) phosphatases II 718-938 1.6e-32 108.0 In-house 2-169 (178) alignment 
Range on Protein: 718-938
Range on HMM: 2-169/178.0
YDHSRVKVAPTSHNNNTDYINANFVDGYhgpkEFIATQGPlpvtcVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEAAtkygdvivrplsqeenk
.|..||.. . .. . .|||||......     ......|     ........|.   .||..|  . ....||..|||.||                  
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

vyikrvfqlqkdgetreiAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGlKNKHPIVVHCSAGVGRTGTFIALDRLFRAvdhadleNLDVRAVVANMRH
                   |. ....||||.||..  . |   .....   ....|..|||||||||.||..|.. . .        .|.. .... .| 
..................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl.......glsleeaielvre

SRTmMVQALPQYEYIHKTLKD
 |  .|.   |......  . 
rRp.ivpnpgqlrqLyefelr
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 718-848 2e-12 41.6 In-house 5-126 (130) alignment 
Range on Protein: 718-848
Range on HMM: 5-126/130.0
YDHSRVKvaptshnnNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQaVAIVMVTaliqGNRVKCHQYWPDEAATK-YGDVIVRPLSQEEN
.. ||..        . .||||.||      .|.. || ||  |.. ||.|. |.  | ...|     |   .  .||||    . | . |.  |.. ..
fevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmlery.vnvlvvl....gsveeedeywpdsePlewyeediivtltdrde

KVYIKRVfQLQKDGETRE----IAQFEFLNWPDHGA
  .||   .|. . .  |    .. |.  |||  |.
fknikas.nleiesdlneshqaltmfqisnwpsdgt
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 719-948 8.8e-17 56.2 In-house 31-267 (290) alignment 
Range on Protein: 719-948
Range on HMM: 31-267/290.0
DHSRVKVAPTSHNNNTDYINANFVDGYHGpKEFIATQGPLPVT-------CVSFWQMIWEQQAVAIVMVTALIQGNRV----KCHQYWPDEAA--TKYGD
 ..||         | ||| ||.|   .|  ..|.|| |.  .         .|| |. . ..  .||.    . ..      | .| |...    |...
eatrvvLkgygkrfnddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg

VIVRPLSQEENKVYIKRVFQLQKDG-ETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRsytglKNKHPIVVHCSAGVGRTGTFIALDRLFRAVDHaDLE
. |.  |.|...  ..|   .. |. |   .    . .| .  ....|  ...    |.     ..| |..|||  |. |  .. |..  .  . .   .
ltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiilgyQkiae.tsg

NLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMMQQLRQVK
.. ...|. ..|. | ....   .. ..   .  .... |.|. 
svkledvlkalrkqralaitsalelafvdagivllaievldqfa
0046846 (Phosphotyrosine protein) phosphatases II 727-939 3.5e-41 136.2 In-house 5-172 (176) alignment 
Range on Protein: 727-939
Range on HMM: 5-172/176.0
PTSHNNNTDYINANFVDGYHgpkeFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEAATKYgdvivrplsqeenkvyikrvfql
.. .... ||||||...|..    .|||||||| |. .|..|..|..  |.|..| ... .|.||..|||.. . ..                       
llgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

qkdgetreiaQFEFLNWPDHGAPDStMDMIEYRTAVRSYTglKNKHPIVVHCSAGVGRTGTFIALDRLFRAvdhadlENLDVRAVVANMRHSRT-MMVQA
          |. .|.|||||.||.  ...|   ..|..   |...|..||||||.|||||..|.. | .        .|.|  ..| .|  |  ..|| 
..........qylhlpwpDhgvpdl.elllellefireal..keggpvlVHCsaGigRtgtlvaayllele......kglsveealalvreqRplgavqt

LPQYEYIHKTLKDY
  ||..... .. .
peQyrflyefelll
0043147 (Phosphotyrosine protein) phosphatases II 732-933 1e-43 144.3 In-house 3-154 (172) alignment 
Range on Protein: 732-933
Range on HMM: 3-154/172.0
NNTDYINANFVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALiqgnrvkchqywpdeaatkygdvivrplsqeenkvyikrvfQLQKDGE
...|||||...|.|. |..||||||||. |. .||.|..|..  .||..| |                                         .. ....
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.........................................lydpell

TREIAQFEFLNWPDHGAPdSTMDMIEYRTAVRSYTGLKNKHPIVVHCSAGVGRTGTFIALDRLFravdhadlENLDVRAVVANMRHSRTMMVQALPQYEY
.|.. |. .|.|||||.| ..  ..|    ....  |....|..||||||||||||..|.. .         ..|..  .|| .|. | ..||   || .
erlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml........lglsleeavalvrekRpgavqnpsqyrf

IH
..
ly
0051429 (Phosphotyrosine protein) phosphatases II 733-941 3.7e-46 153.3 In-house 3-226 (272) alignment 
Range on Protein: 733-941
Range on HMM: 3-226/272.0
NTDYINANFVDGYHG---PKEFIATQGPLPVTCVSFWQMiWEQQAVAIVMVTALIQGNRVKCHQYWP------------DEAATKYGDVIVRPLSQEENK
 ..||||..|.||..   |. .....||||.|. .||.. .|..  .||... .   .|.||..|||            ..    ||.. |. || |   
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

VYIKRVFQLQ---KDGETREIAQFEFLNWPDHGAPDSTmdMIEYRTAVRSytglknKHPIVVHCSAGVGRTGTFIALDRLFRAVDHADLEN------LDV
.|| |...|    . ||.||. .. ...|||||.|...  ..|   ....      ..|..||||||..||||..||..| . |.. .  .      | .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

RAVVANMRHSRTMMVQALPQYEYIHKTLKDYMM
...|. .|  |  .||   ||..... |.....
eeaveelraqrpgavqteeqylflyeallellr
0036282 (Phosphotyrosine protein) phosphatases II 734-934 1.8e-45 150.1 In-house 2-164 (174) alignment 
Range on Protein: 734-934
Range on HMM: 2-164/174.0
TDYINANFVDGYHGPKEFIATQGPLPvtcvsFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDeaatkygdvivrplsqeenkvyikrvfqlQKDGETR
.|||||...|... ....||.||||.     ||.|..|..  ..||.. ... ...||..|||.                              .. ..|
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.............................lredler

EIAQFEFLNWPDHGAPDSTMdMIEYRTAVRSYTGLKNKHPIVVHCSAGVGRTGTFIALDRLFRAVDhadLENLDVRAVVANMRHSRTMMVQALPQYEYIH
.. |. .|.|||||.||... ..|   .|...   ....|..||||||||||||..|.... |          |. ..|. .|  | .|||   ||....
lgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll...eslvdaldlvrelRlqrpgmvqtpsQyrfly

K
.
y
0051082 (Phosphotyrosine protein) phosphatases II 734-934 2.7e-32 106.8 In-house 3-147 (151) alignment 
Range on Protein: 734-934
Range on HMM: 3-147/151.0
TDYINANFVDGYhgpkeFIATQGPLPvtcvSFWQMIWEQQAVAIVMVTALIQGNrvKCHQYWPDEAatkygdvivrplsqeenkvyikrvfqlqkdgetR
.||||...|.|.     .....|||.     |.....|..  .||... .   .  .|..|.|..                                  .
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................i

EIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSytglKNKHPIVVHCSAGVGRTGTFIALDRLFRAvdhadlenLDVRAVVANMRHSRTMMVQALPQYEYIH
|. .. .|.|||.| |.|.  ..|.  ....    |...|..||||||.|||||..||... .         ... .... .| .|...||   |. ...
evlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg........vsleealeeyrlkrpgvvqpnqqflfql

K
.
f
0049260 (Phosphotyrosine protein) phosphatases II 741-934 7.3e-40 131.5 In-house 1-144 (152) alignment 
Range on Protein: 741-934
Range on HMM: 1-144/152.0
FVDGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWpdeaatkygdvivrplsqeenkvyikrvfqlqkdgetreiaQFEF
|.|||. |.||||||||.| |. .||.|..|... .|||.| |   ...||.||.                                         |. .
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.........................................qylh

LNWPDHGAPDSTMDMIEYRTAVRSYtGLKNKHPIVVHCSAGVGRTGTFIALDRLFravdhadlENLDVRAVVANMRHSRTMMVQALPQYEYIHK
|.|||||.||... ...   ... .  |....|..||||||||||||..|.. .          ....  .|| .|  | ..|.   |......
lpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml........lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 743-845 1.5e-11 38.3 In-house 230-330 (440) alignment 
Range on Protein: 743-845
Range on HMM: 230-330/440.0
DGYHGPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTaliQGNRVKCHQYWPDEA-ATKYGDVIVRPLSQ-EENKVYIkRVFQLQKDGETREIAQFEF
.||   . ||||| ||  | . ||... . .  .|.|.    | |   |  ||| .. .  .|   |      . |.| . | ..|.   |  || ||| 
egyskknafiatqmpldstvldfwrlvhdyristiimln...qlndktcsiywpvntrsvtfgpftvghkgsenmnrvkv.rtlelkykeevheirqfev

LNWPD
  || 
qtwpt
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 747-934 7.6e-24 79.0 In-house 3-198 (199) alignment 
Range on Protein: 747-934
Range on HMM: 3-198/199.0
GPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPD--EAATKYGDVIVRPLSQEENKVYIKRVFQLQK----DGETREIAQFEF
| . .|||| ||  |   ||||.||  .  ||||    . . .    |||    ...||| . |   .   .  |   .. | .       ||||....|
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

LNWPDHGAPDSTMD---MIEYRTAVRSYTGLKnKHPIVVHCSAGVGRTGTFIALDRLFRAVDHADLENLDVRAVVANMRHSRTMMVQALPQYEYIHK
  | .. .|. ..    ..  |   . |   |   |..|||| | | || |.|||   |. . .    .|.  |   .| .|  .. .|..|..|..
tswkekttpnvalfvgfvvasrevskkyeqek.dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 747-934 9.9e-24 78.6 In-house 2-197 (198) alignment 
Range on Protein: 747-934
Range on HMM: 2-197/198.0
GPKEFIATQGPLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPD--EAATKYGDVIVRPLSQEENKVYIKRVFQLQK----DGETREIAQFEF
| . .|||| ||  |   ||||.||  .  ||||    . . .    |||    ...||| . |   .   .  |   .. | .       ||||....|
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

LNWPDHGAPDSTMD---MIEYRTAVRSYTGLKnKHPIVVHCSAGVGRTGTFIALDRLFRAVDHADLENLDVRAVVANMRHSRTMMVQALPQYEYIHK
  | .. .|. ..    ..  |   . |   |   |..|||| | | || |.|||   |. . .    .|.  |   .| .|  .. .|..|..|..
tswkekttpnvalfvgfvvasrevskkyeqek.dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 757-941 8.2e-16 52.3 In-house 99-289 (302) alignment 
Range on Protein: 757-941
Range on HMM: 99-289/302.0
PLPVTCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEAA--TKYGDVIVRPLSQEEN--KVYIKRVFQL--------Q-KDGETREIAQFEFLNW
|   |.  .| .| . .   .| ........  || .|. |.     |.|   |. .| ...  .   |. |.|        . |.   . .  . |  |
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHGAPDSTMDMIEYRTAVRSYtglknKHPIVVHCSAGVGRTGTFIALDRLFRAVDHADLenLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMM
||||||. .   ..      ||     |. ..||||||||||||..|.        . .    |.  .|  .|. |   ||   |  |.   .   .|
pdhGapkeaytaldilkfcesy.....kknvlvhcsaGvGrtGtlvaikyGiqlcskkkv..tdllsivlpvrqcryGavqdeqqliylllcvtkglm
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 761-924 1.7e-19 64.9 In-house 40-205 (255) alignment 
Range on Protein: 761-924
Range on HMM: 40-205/255.0
TCVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEAAT--KYGDVIVRPLSqEENKVYIKRV---FQLQKDGETREIAQFEFLNWPDHGAPDSTMDM
|   |.|.|  ...  .||.. . . ...||..|.| |     |. || |       ..| .. .    .| .  .|...  ...  |... ||. . ..
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei

IEYRTAVRsytglkNKHPIVVHCSAGVGRTGTFIALDRLFR----AVDHADLENLDVRAVVANMRHSRTMMVQ
 .   .||      . ...|||||.|.||. .|.  . ...    ..| ..  .|| . .. ..|..|.  ..
lnilkvvr......dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraih
subfamily_hpo-7_pd Subfamily hpo-7 762-941 4.4e-17 56.9 In-house 47-228 (263) alignment 
Range on Protein: 762-941
Range on HMM: 47-228/263.0
CVSFWQMIWEQQAVAIVMVTALIQGNRVKCHQYWPDEAAT--KYGDVIVRPLSQEENKVYIKRVFQ--LQKDGETREIAQFEFLNWPDHGAPdstMDMIE
  .|.|.|  ...  .||..     ...|| .|.| |     |. .| |      .. .   ...   |..  .|... .. .  |... .|   ....|
idkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndp...elare

YRTAVRSYTGLknkHPIVVHCSAGVGRTGTFIALDRLFR----AVDHADLENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYMM
 .  ..  ...   ...|||||.|.||.  |   . ...    ..| ..  .|| . .. ..|.||.  ..   |  .   .. |...
ilnilkvarns...kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvl
0048076 (Phosphotyrosine protein) phosphatases II 820-938 2.1e-23 78.0 In-house 30-141 (145) alignment 
Range on Protein: 820-938
Range on HMM: 30-141/145.0
IKRVF--QLQKDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYtgLKNKHPIVVHCSAGVGRTGTFIALDRLFRavdhadlENLDVRAVVANMRH
|..|.     .....|.. |. .|.|||||.||.. ...|   .....  ||...|..||||||||||||..|.. ...       .....  ... .| 
ittvlnltselellerlgiqylylpwpDhgvpdllellleflefieea..lkeggpvlVHCsaGvgRtgtlvaaylmll.......lgvsleealelvrs

SRTMMVQALPQYEYIHKTLKD
 | ..|.   |...... .. 
qrpgavpnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 828-934 4.1e-22 73.9 In-house 42-139 (144) alignment 
Range on Protein: 828-934
Range on HMM: 42-139/144.0
KDGETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGlkNKHPIVVHCSAGVGRTGTFIALDRLFravdhadLENLDVRAVVANMRHSRTMMVQALP
.. ..||. |. .|.|||||.||.. ...|   .....    ...|..||||||||||||..|.....       ...|..  ..| .|  | ..|.   
pefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk.......klglsleealalvrsrrpgavpnpg

QYEYIHK
|......
qlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 831-938 3.9e-16 53.4 In-house 87-192 (440) alignment 
Range on Protein: 831-938
Range on HMM: 87-192/440.0
ETREIAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGLKNKHPIVVHCSAGVGRTGTFIALDRLFRAVDHADleNLDVRAVVANMRHSRTMMVQALPQYE
|.| . |. .  |||.| |  .  ...    |        . |..||||||.||||  ||.| ..| . ..|  ..|. ... .|| .|  |||.  || 
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsd..qidifsfinsmrnnrpqmvqtpeqya

YIHKTLKD
..|... .
fvheavle
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 833-941 1.5e-11 38.2 In-house 218-345 (349) alignment 
Range on Protein: 833-941
Range on HMM: 218-345/349.0
REIAQFEFLNWPDHGA---PDSTMDMIEYRTA------VRSYTGLKNKHPIVVHCSAGVGRTGTFIALDRLFR--AVDHADLENLDVRA--------VVA
 |. |. . ||.| .    | | .  .| .         | |   ..  ...|||||| ||||... || |.      . .   ....|        .| 
yellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivn

NMRHSRTMMVQALPQYEYIHKTLKDYMM
..|  |  ||| | |.  |...|  |. 
elrkqrismvqnlaqfiaiyealLkyfa
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 834-942 1.9e-16 54.7 In-house 216-346 (350) alignment 
Range on Protein: 834-942
Range on HMM: 216-346/350.0
EIAQFEFLNWPDH---GAPDSTMDMIE------YRTAVRSYTGLKNKHPIVVHCSAGVGRTGTFIALDRLFR----------AVDHADLEN---LDVRAV
.. |. . ||.|      | | . ..|           .|.   ..  ||.||||||||||||...|| |.              . |  .     .  .
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VANMRHSRTMMVQALPQYEYIHKTLKDYMMQ
| ..|. |  ||| | |. .|...|. |   
vnelrkqrismvqnldqfifiYeallfyfaL
subfamily_PTPDC1_pd Subfamily PTPDC1 834-934 1.8e-06 22.5 In-house 82-170 (182) alignment 
Range on Protein: 834-934
Range on HMM: 82-170/182.0
EIAQFEFlNWPDHGAPD--STMDMIEyrtaVRSYtGLKNKhPIVVHCSAGVGRTGTFIALDRLFRavdhadlENLDVRAVVANMRHSRTMMVQALPQYEY
.|. ..|  |.|.|..   . .|..     | ..  |...  . ||| || ||||  ||   ..        ..|.    .  .|. |.  .|.  | | 
giyvynf.gwkDygvasleriLdivk....vvaf.alqeg.kvavhChaGlGrtGvliacylvya.......krltaekaiklvrskrpksiqtreqvel

IHK
...
vke
PTPc_DSPc_SM00012 835-936 3.9e-28 93.1 In-house 2-103 (105) alignment 
Range on Protein: 835-936
Range on HMM: 2-103/105.0
IAQFEFLNWPDHGAPDSTMDMIEYRTAVRSYTGLKN-KHPIVVHCSAGVGRTGTFIALDRLFRAVDHADlENLDVRAVVANMRHSRTMMVQALPQYEYIH
. ......|||||.|... ...|.  ||.. .  .. ..|.||||||||||||||.||| | . ...   ...|.  .|  .|..|  ||| . || ...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket.kevdifqivkelrkqRpgmvqteeqylfly

KTL
. |
ral
PTEN_1 841-890 3.3e-10 35.1 In-house 100-149 (196) alignment 
Range on Protein: 841-890
Range on HMM: 100-149/196.0
LNWPDHGAPDSTMDMIEYRTAVRSYTGLKNKHPIVVHCSAGVGRTGTFIA
. ..|||||.  . . . . .  ..  ..|.. ..||| ||.||.|| .|
fpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
0038934 (Phosphotyrosine protein) phosphatases II 841-929 1.1e-09 33.7 In-house 85-166 (194) alignment 
Range on Protein: 841-929
Range on HMM: 85-166/194.0
LNWPDHGAPDSTMDMIEYRTAVRSYTGLKNKHPIVVHCSAGVGRTGTFIALDRLFRavdhadlENLDVRAVVANMRHSRTMMVQALPQY
| .||.|.. |.  . ..  .|  ..  .... ..||| ||.|||||..|   . |        ...... .| .|  |  ...   ..
lpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr.......lgmsaeeAialfrekRpgaipnqdyl
subfamily_PTEN_pd Subfamily PTEN 841-933 1.4e-06 23.5 In-house 85-173 (184) alignment 
Range on Protein: 841-933
Range on HMM: 85-173/184.0
LNWPDHGAPDSTMdMIEYRTAVRSYTGLKNKHPIVVHCSAGVGRTGTFIALDrLFRAVDHADLEnlDVRAVVANMRHSRTMMVQALPQYEYIH
..  || .|   . . |  . ....   ..|. .|||| || ||||. |.   |. .    . |  ..... |..| . .  |.   |  |..
ypfdDhnppplel.leeivediekwleedkknvvvvHCkaGkGRtGvlivay.llkslllekae..ealelfaeaRtknkkgvtiPsqrRYve
subfamily_CG42327_pd Subfamily CG42327 863-940 5.6e-15 49.8 In-house 238-315 (319) alignment 
Range on Protein: 863-940
Range on HMM: 238-315/319.0
RSYTGLK-NKHPIVVHCSAGVGRTGTFIALDRLFRAVDHADlENLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKDYM
 | .| . .. |.||||| ||||||. || |  .| ....  . .|.  .|  .|. |.  |..  |||.|.|.|  | 
ssrsgtresqGPlvvhcsdGvGrtGlviasdiairsleesk.rsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 872-934 9.1e-11 36.2 In-house 229-289 (297) alignment 
Range on Protein: 872-934
Range on HMM: 229-289/297.0
HPIVVHCSAGVGRTGTFIALDRLFRAVDHADLEnlDVRAVVANMRHSRTMMVQALPQYEYIHK
 ...|||||||||.|  .  | .   . .  .   ||.|..  .|. |...||.| |.|....
ayllvhcsaGvGrsGvvvlsdvilaklrkkrip..dvaailsilreqrarlvqtleqfellyd
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 874-937 1.7e-10 35.1 In-house 1-62 (69) alignment 
Range on Protein: 874-937
Range on HMM: 1-62/69.0
IVVHCSAGVGRTGTFIALDRLFRAVDHADLenLDVRAVVANMRHSRTMMVQALPQYEYIHKTLK
.|||||.| ||||||||.      .    |  .|.   |  ||  | |||    .| .|| .| 
mvvhcssgtgrtgtfiaimvemariksekl..vdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 875-938 2.2e-10 34.7 In-house 1-62 (69) alignment 
Range on Protein: 875-938
Range on HMM: 1-62/69.0
VVHCSAGVGRTGTFIALDRLFRAVDHADLenLDVRAVVANMRHSRTMMVQALPQYEYIHKTLKD
|||||.| ||||||||.      .    |  .|.   |  ||  | |||    .| .|| .| .
vvhcssGtGrtGtfiaimvemariksekl..vdifnnvqymrkcrpmmvmneneymfihdalve