Gene MbrePTP-sf1-7 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily MbrePTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP038_AA protein Get Run
MbreP038_AA_43-318 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 31-320 2.5e-63 208.9 In-house 8-282 (315) alignment 
Range on Protein: 31-320
Range on HMM: 8-282/315.0
LDQMVTYLVSESRRLKthlrglqqqpQGWQMEYGGLaPIGTDQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIA
|||..||.  .    |          .|.. .|  . | |  .| . .|. ||. .||||||.|||.||| .   |  .. ||.|||...||.  . |||
ldqlityvaqkkastk..........ngfkqdyesi.pggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryia

CQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPnsELRVGNFVIKSISEVARTSFIERHFELTDQTSGQTvpVQQMQYILWPDHGVPN
.||| . .   ||....|. .| |||.|| ||  | |. .||||   ..  |.. .  .||   | .  | .  . .   ..  | |..|  ||| |||.
aqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgdnire..vvqlhytswpdmgvpk

TTRDLLNFRDEIYRAHDP-RTPLVIHCSAGVGRTGTYIAIDRLCNAAEdMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAIDRG
 |  |.|.   . . |.   ...|.|||||||||||.|..| . . || .  ..   ...  .|. |  .||.. || |.| |||...  |
ytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqae.aenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcg
subfamily_PTPRD_pd Subfamily PTPRD 44-375 2.7e-93 308.5 In-house 9-341 (564) alignment 
Range on Protein: 44-375
Range on HMM: 9-341/564.0
RLKTHLRGLQ-QQPQGWQMEYGGLAPIgTDQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAF
.||.|.. |. .. .  ..||  . .  .  . ||.. |.|   ||| ||||||||||  .. |.... |||||... ||. .||||| |||...... |
elkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedF

WQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPNsELRVGNFVIKSISEVARTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEI
|.|.||| .  |||.|. .| || |||.|||. . . ..|.....  .|.  . .. |.|.|....| ..  |.| ... |||||||.....||......
WRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkv

YRAHDPRT-PLVIHCSAGVGRTGTYIAIDRLCNAAEDmHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAIDRGLGQA--KQAISLLDEQAGTVL
 ... | . |.|.|||||||||||.|.|| . . ...   ..  . .|...|| ||..|||  || |.. |.|.|.. |  .   ..  . |.. | .. 
ralnepdagPivVhCSaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaevee

QTELNDLNQELAVAAEAQKAHPESDKGQQDIENLQK
.||   |..|    | |.. ..|. .  .. .|..|
dtemtgleleFqrLatakeieleefavatkpknkkk
0051299 (Phosphotyrosine protein) phosphatases II 44-317 9.3e-86 283.1 In-house 10-286 (288) alignment 
Range on Protein: 44-317
Range on HMM: 10-286/288.0
RLKTHLRGLQQQPQGWQMEYGGLAPIGTDQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFW
 ||. |. |. .. |...|.  | .. .| .  |...|||.. ||| .|..|||||| ... .   ..|||||....||. ....||.||| |. .. ||
llklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFW

QMIWEQAVGLIVMITNEVEAGKLKCHRYWPDpNSELRVGNFVIKSISEVARTSFIERHFELTDQ----TSGQTVPVQQMQYILWPDHGVPNTTRDLLNFR
.|.||| | .|||.|..|| |. ||..|||. .. | .|..... .||.   ... |..|.|.      .|..  |....|. |||||||.....||.| 
rmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldfl

DEIYRA-HDPRTPLVIHCSAGVGRTGTYIAIDRLCNAAEDMhPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAI
 ....|  ..  | |.|||||||||||.||.| |..  |    .. . ..|. .|. |...|||. || ||| |||...
rlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 44-324 4.3e-81 267.4 In-house 6-287 (318) alignment 
Range on Protein: 44-324
Range on HMM: 6-287/318.0
RLKTHLRGLQQQPQ-GWQMEYGGLAPIGTDQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAF
 |..|.| |... .   . ||  |..      .  |  | | ..|||.||.||||.|| ... | ... ||||||...||. .|||||.|.|.|...  |
dleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDf

WQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPNSElRVGNFVIKSISEVARTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEI
|.|.|||   .|||.|.|.|.|| |.|||||. .|.   |. |..  .||  .... |.|..| . . ..  |.| .|  |||.|||. . .||..  ..
WrmvWeqnsavivmltqeeergkakvhryWPskgsr.sygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqv

YRAH--DPRTPLVIHCSAGVGRTGTYIAIDRLCNAAEDmHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAIDRGLGQA
 .|.    ..|.|.||||||||||..||.| | . ...   ..   ..| ..|. || .|||  || |.| .||.|.  |  ..
skaqqksgagpivvhCsaGvGrtGvfiavdillerika.ealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 45-321 5.6e-132 434.0 In-house 2-280 (281) alignment 
Range on Protein: 45-321
Range on HMM: 2-280/281.0
LKTHLRGLQQQP-QGWQMEYGGLAPIGTDQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFW
|..||. |.|.  .|...|| .|| ||.|..|.|||..|||..|||.||||||..||.|.|.|..||.||||||.||||||.|.|||.|||||....|||
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW

QMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPNSELRVGNFVIKSISEVARTSFIERHFELtDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIY
||.|||.| .|||.|.|.|||||||||||||.||||..|....||..| .....|||.|.| ...||.|. |.|..|. |||||||.||..||.||.|..
qmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevl

RAHDPRT--PLVIHCSAGVGRTGTYIAIDRLCNAAEDMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAIDRGL
......|  ||||||||||||||||||.|||..|.|.....|....||||.||.||..|||.||| |||.|.|||.|. |
kltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldkel
subfamily_PTPRB_pd Subfamily PTPRB 46-319 3.1e-87 287.3 In-house 13-287 (293) alignment 
Range on Protein: 46-319
Range on HMM: 13-287/293.0
KTHLRGLQQ-QPQGWQMEYGGLAPIGTDQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQ
..|.. ... .  ... ||  |  .|.||  .|.....| ..||| ||..|||||| ... . ....||||||..|||.  . .||.|||.|...  ||.
eehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWr

MIWEQAVGLIVMITNEVEAGKLKCHRYWPDPNSELRVGNFVIKSISEVARTSFIERHFELTDqtSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYR
|.||. .  |||.|. || || ||..|||. ...   |.  .. ..|   . .. |.....   . ..  |.|.... |||||||..|. ||.|  .. .
mvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvre

AH---DPRTPLVIHCSAGVGRTGTYIAIDRLCNAAEDmHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAIDR
|.     ..|.|.|||||||||||.||.||| .| |. . ..    .|||.|..||.||||  || |.. ..|| . .
aiektaskrPivvhCsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 48-315 3.5e-33 109.6 In-house 13-285 (305) alignment 
Range on Protein: 48-315
Range on HMM: 13-285/305.0
HLRGLQQQPQGWQMEYGGLAPIGTDQPAEASKRPENVTQNRYINIVAYDHSRVTVkpsEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIW
  | |...|.| . |. ..  .   .  .| |  ..  .||| ..   |. || .   |..   .|| ||.|      | .| .| |. .. | || | .
vkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymcl

EQAVGLIVMITNEVEAGKLKCHRYWPDPNSE---LRVGNFVIKSISE-VARTSFIER------HFELT-DQTSGQTVPVQQMQYILWPDHGVPNTTRDLL
.. |  | |. | .| |  ||. |..  . .   .. ..  |    |  .. .| .       . .|. . . ...  |..  .| ||| ||| .   .|
qdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlail

NFrdeIYRAHDPRTPLVIHCSAGVGRTGTYIAIDRLCNAAEDMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLD
..   . .|   . |.|.|||||.||||. . .. ...     . . .   ..  .|. ||  .||  || ||.  .|.
el...lekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
0050432 (Phosphotyrosine protein) phosphatases II 49-321 4.9e-86 284.1 In-house 36-303 (308) alignment 
Range on Protein: 49-321
Range on HMM: 36-303/308.0
LRglQQQPQGWQMEYGGLAPIGTDQPAEASKRPENVTQNRYINIVAYDHSRVTVkpseaTKNNDYINANWVPGY--KGDKAYIACQGPVPDAFAAFWQMI
 .  . .......|.  |  . .. . .....|||.. ||| .|..|||||| .      ...|||||..|.||  | ....||.||| |. .. ||.|.
ek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmv

WEQAVGLIVMITNEVEAGKLKCHRYWPDP--NSELRVGNFVIKSISEVARTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYR
||| | .|||.|..|| |. ||..|||.   .. |..|.|... .||  . ... |..|||.  .|..  |....|. |||||||. ...||.| ... .
weqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrk

AHdPRTPLVIHCSAGVGRTGTYIAIDRLCNAAEDMhPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAIDRGL
 . |  | |.|||||||||||.||.| |..  |    .. . ..|. .|. |.. |||. || |.| |||. . . |
sl.pggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0045450 (Phosphotyrosine protein) phosphatases II 51-316 1.7e-80 266.3 In-house 21-303 (307) alignment 
Range on Protein: 51-316
Range on HMM: 21-303/307.0
GLQQQPQGWQMEYGGLAPIGT--DQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEAT-KNNDYINANWV--------PGYKGDKAYIACQGPVPDAF
 |.  ..|.. |.  | .. .    . .....||| . ||| .|..|||.|| ... . . ...|||||..|        .||. ....||.||| |. .
llldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetv

AAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPNSELRVGNFVIKSISEVARTSFIERHFELTDQ-TSGQTVPVQQMQYILWPDHGVPNTTRDLLNF
. ||.|.||| |..|||.|..|| |. ||..|||| ..||  |||... .||    ... |..|.||   .|..  |....|. ||||||| .. .||.|
edFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldf

RDEIYRAHD---PRTPLVIHCSAGVGRTGTYIAIDRLCNAAEDMHPM--LHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDA
 .|. .|..   . .| ..|||||||||||.||.. ..   |. . .  . ....|...|. |   ||.. || |.| |||. 
ieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_Ptp69D_pd Subfamily Ptp69D 51-320 2.2e-69 228.9 In-house 15-289 (307) alignment 
Range on Protein: 51-320
Range on HMM: 15-289/307.0
GLQQQP-QGWQMEYGGLAPIGTDQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQ
  .... .| . ||  |    .|. ...|.. ||  .||| .|.|.|. || .|. . ... |||||... |||  | .|| |.||      ||.||.||
srkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeq

AVGLIVMITNEVEAGKLKCHRYWPDPnSELRVGNFVIKSISEVARTSFIERHFELTDQT-----SGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYR
 | ||||..|. |  . ||..|||.   | . |. ..| .||   . .|.|..... .        ..  | | .|  |.|  ||...| ||.. .... 
evtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvre

A-HDPRTPLVIHCSAGVGRTGTYIAIDRLCNAAEDmHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAIDRG
  .  |.|.|.||||||||.|...|.| | .  .     ..  ..| ..|. ||.||| | || |.| |||| .. |
lyklnrsPivvhCsaGvgrsgifvaldsllqqlka.edkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg
0040438 (Phosphotyrosine protein) phosphatases II 54-318 6e-84 277.3 In-house 15-277 (317) alignment 
Range on Protein: 54-318
Range on HMM: 15-277/317.0
QQPQGWQMEYGGLAPIGTDqPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGL
 . .... |.  |  .  | . . ...|||   ||| .|. |||||| ..| .   ..|||||..|.|..  ...||.||| |. .. ||.|.||| |..
sdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

IVMITNEVEAGKLKCHRYWPDpNSELRVGNFVIKSISEVARTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDP-RTPL
|||.|...| |. ||..|||. ...| .|.|... .||.   ... |..|..|  ..... |....|. ||||||| ....||.| ... .| ..  .|.
ivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpv

VIHCSAGVGRTGTYIAIDRLCNAAEDMHpMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAID
..|||||||||||.||......  |  .  . . ..|.|.|. |.  |||. || |.| |||. . 
lVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylk
0043336 (Phosphotyrosine protein) phosphatases II 54-315 1.2e-78 259.7 In-house 17-275 (278) alignment 
Range on Protein: 54-315
Range on HMM: 17-275/278.0
QQPQGWQMEYGGLAPIGTdQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGL
  ..... |.  |  . .  . . ...|||.. ||| .|..|||||| ... .   ..|||||..|.||.  ...||.||| |. .. ||.|.||. |  
nlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

IVMITNEVEAGKLKCHRYWPdpNSELRVGNFVIKSISEVARTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHD-PRTPL
|||.|..|| |. ||..|||  .. |..|.|... ..|     .. |..|.|.  .|..  |....|. ||||||| .. .||.|  .. .| . . .|.
ivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpv

VIHCSAGVGRTGTYIAIDRLCNAAEDMHpMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLD
..|||||||||||.||...|.. .|. .  . . ..|.|.|. |   |||. || |.| |||.
lVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_PTPN9_pd Subfamily PTPN9 54-315 5.8e-67 220.8 In-house 13-288 (297) alignment 
Range on Protein: 54-315
Range on HMM: 13-288/297.0
QQPQGWQMEYGGLAPIGTDQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGL
.. .| . ||  .    .   ..||| . |...||| ... ||..||...  . ... ||||||.| |||  ||.|| |||.. ..  ||.|.||| |  
kgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlv

IVMITNEVEAGKLKCHRYWP-DPNSELRVGNFVIKSISEVARTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIY---------
|||.|  || |.||| .||| . .|  . |.. ..... . .  . .| .|... . ...  |   |.. |||.|||... .||......          
ivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavke

-----RAHDPRTPLVIHCSAGVGRTGTYIAIDRLCNaAEDMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLD
     . |    |.|.|||||.|||||.|..|   .   ..  ... ...|  .|. | | .||  || | |||.|.
lgdewkghpsgPPivvhcsaGiGrtGtfitldicls.rleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 54-319 2e-60 199.1 In-house 17-285 (290) alignment 
Range on Protein: 54-319
Range on HMM: 17-285/290.0
QQPQGWQMEYGGLAPIGTDQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKN--NDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAV
.. .|.. ... |     .. ..    ..| ..||. ||| ||  |.|..|    |.  |.|||| .. ||| .|.||| ||||..  . ||..||.. |
kgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekv

GLIVMITNEVEAGKLKCHRYWPDPNSELrVGNFVIKSISEVARTSFIERHFELTDQTS-GQTVPVQQMQYILWPDHG-VPNTTRDLLNFRdEIYR--AHD
  |||.||..| || ||. |||| ...  .|.| || ..| . ...|||..|.....| |..  |.| |   |...| |.|..  || .. |.|.   ..
tiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvie.emyktqrkr

PRTPLVIHCSAGVGRTGTYIAIDRLCNAAEDmHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAIDR
 .|..|.|||..|||.....|..   | ..         .|. ..|  .  .||| .|| ...  .| ..|.
gntsivvHCSdtvgrsavfcaaattinkckt.egvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 54-352 2.3e-51 169.8 In-house 20-319 (325) alignment 
Range on Protein: 54-352
Range on HMM: 20-319/325.0
QQPQGWQMEYGgLAPIGTDQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMI--WEqav
|. .|.  |.| | |    .  ... .|||. .||. |.||.|.||| ..  .   . |||||...  .|. . ..|.| | ...   .|...  |.   
qdqdgfahefg.llpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...

GLIVMITNEVEAGKLKCHRYWPDP-NSELRVGNFVIKSISEVARTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRD------EIYR
  .|...||.. || .|  |||.      . | . .| ..    . .. | ... .   |.|  |.|.|.  |.| ||..    |... .      |  .
csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservt

A-HDPRTPLVIHCSAGVGRTGTYIAIDRLCNA-AEDmhPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAIDRGlgQAKQAISLLDEQAGTvLQtE
|     ||...||||||||||..|..  . .   |.    .   ..|  .|| |  .|.|  || ..| || .|.  |  ..   .| .. .  . || |
antkastpilvhcsaGvGrtGvfislysalakviee..srvdifgfvkklrkdrpsmvetvdqyiliyealveaymsg..ntdvpvssfeaklss.lq.e

LNDLNQELAV
 | | |.| .
rnpltqklni
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 55-318 9.2e-80 262.8 In-house 19-280 (288) alignment 
Range on Protein: 55-318
Range on HMM: 19-280/288.0
QPQGWQMEYGGLAPIGTDQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLI
. .| . ||  ||... ..  .|.....| ..||| ||..||. || .|  | ....|||||... |.|..|.||| |||..|.   ||....|. .  |
nrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktsti

VMITNEVEAGKLKCHRYWPDPNSELRVGNFVIKSISEVARTSFIERHFELTdqTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDPR-TPLV
||.|. || || ||..|||| . . . |.. .. ...   ..|..|...|    ... . ..|.||  |||||||. ...||.... .  |..    |..
vmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpii

IHCSAGVGRTGTYIAIDRLCNAAEDmHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAID
.|||||||||||.||.| | .| |  . ..   ..||..||.|..||||| || |.| .||. |.
vhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevllslie
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 55-318 4e-64 211.7 In-house 20-284 (305) alignment 
Range on Protein: 55-318
Range on HMM: 20-284/305.0
QPQGWQMEYGGLAPIgtDQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLI
. .|....|  |.    ... .  |. .|...||. .|. .|..|. ....| ....|||||..| |||. |.||. |||...  | ||..|.|  |  |
sdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

VMITNEVEAGKLKCHRYWPDPNSE-LRVGNFVIKSISEVARTSFIERHFELTD-QTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDPR--T
||.|. || || ||..|||.  .|  . |.|...  || . . .|||.....  ... ..  | |.|   |||||||...  ||.. ... ...     .
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgv

PLVIHCSAGVGRTGTYIAIDRLCNAAEDmHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAID
||..||||||||||..||.|   . ..    ..   .|. ..|..|  .|||| || |.. || . | 
pllVhCsagvgRtGvfiavdialerlkk.EevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_PTPRK_pd Subfamily PTPRK 55-317 6e-63 207.5 In-house 20-277 (314) alignment 
Range on Protein: 55-317
Range on HMM: 20-277/314.0
QPQGWQMEYGGLAPIgtdqpAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLI
.  |.. ||  |         .|.|. || ..||. .|.|||.|||.... .   ..|||||... .||  .|.|. |||...  . ||......    |
egygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasi

VMITNEVEAGKLKCHRYWPDPNSElrVGNFVIKSISEVARTSFIERHFELTD--QTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDPR-TP
||.|. || |..|| .|||.  .    |.. .. ..  . . .. | | ..   ..  ..  |.|.|.. ||||.||.  . ||..  ..   ....  .
vmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGr

LVIHCSAGVGRTGTYIAIDRLCNAAEDmHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAI
.|.||||| |||||.|||| ... .|  . ..    .| ..|...  .|.|  || |.| ..|.| 
ivvhCsaGaGrtGtfiaidivldmier.egvvdvfnavktlrsrkvnmveteeqykfiydvileac
0036941 (Phosphotyrosine protein) phosphatases II 56-319 1.4e-82 272.7 In-house 12-279 (297) alignment 
Range on Protein: 56-319
Range on HMM: 12-279/297.0
PQGWQMEYGGLAPIGTDQPAEASKRPENVTQNRYINIVAYDHSRVTVkpseATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIV
..... |.  | |.  . . .....|||.. ||| .|..|||.|| .       ..|||||..|.||. ....||.||| |. .. ||.|.||| |  ||
lalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIv

MITNEVEAGKLKCHRYWPDP-NSELRVGNFVIKSISEVA--RTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHD---PR
|.|..|| |. ||..|||.  ...| .|.|... .|.     .... |..|.||  .|..  |....|. |||||||.....||.| ... ....   . 
mltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsg

TPLVIHCSAGVGRTGTYIAIDRLCNAAED--MHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAIDR
.| ..||||||||.||.||.| ...  ||  ... . . ..| ..|. |.. |||| || |.| |||. . .
gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
0047943 (Phosphotyrosine protein) phosphatases II 56-316 1.2e-79 262.9 In-house 11-271 (273) alignment 
Range on Protein: 56-316
Range on HMM: 11-271/273.0
PQGWQMEYGGLAPIGTDQPAEASKRPENVTQNRYINIVAYDHSRVTVkpseATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIV
......|.  | .. .. . .....||| . ||| .|..|||||| .      ...|||||..|.||.  ...||.||| |. .. ||.|.||| | .||
ltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviV

MITNEVEAGKLKCHRYWPDPNS--ELRVGNFVIKSISEVARTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHD---PRT
|.|..|| |. ||..|||. .   .|..|.| .. .||  . ... |..|||.  .|..  |....|  ||||||| .. .||.| ... .|.      .
mLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsng

PLVIHCSAGVGRTGTYIAIDRLCNAAEDMhPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDA
| |.|||||||||||.||.| |..  |    .. . ..|. .|. |   |||. || |.| |||. 
pvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealley
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 56-317 5.6e-27 89.3 In-house 18-276 (312) alignment 
Range on Protein: 56-317
Range on HMM: 18-276/312.0
PQGWQMEYGGLAPIGTDQPAEASKRPENVtqNRYINIVAYDHSRVTVkpseATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIV
||    ||  .  | .|    |  .  ..  ||| ||  .|  | |.    |  .| || ||.|      . ....|||. .. . |||.    .   |.
pqqltkeykavgnivsdsectaflkfkdl..nrypniqcwdrgrftl....agdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsii

MITNEVEAGKLKCHRYWPDPNSELRVGNF--VIKSI-----SEVARTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRahdP
...  || |  || .|  |  . . . .     ..         ..     | . .  ...||   ... |.  |||||.|..    | .   . .    
llcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk...d

RTPLVIHCSAGVGRTGTYIAIDRLCNAAEdmHPM-LHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAI
. |.. ||||||||||| . |. .  |    ||     .|.   .|| |   |... || ..  ..|. .
kkpviahcsagvgrtgtlaliesmiaalr..hprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 57-320 8.4e-73 240.2 In-house 27-293 (298) alignment 
Range on Protein: 57-320
Range on HMM: 27-293/298.0
QGWQMEYGGLAPIGT---DQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGL
 |...|.  |  .     ..  |....|||  .||| .|.|.|.||| ..  .| .. ||||| .. .||| .|.||.|.|.. ... ||.|..|. .| 
tgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigt

IVMITNEVEAGKLKCHRYWPDPNSElRVGNFVIKSISEVARTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDPRT--P
|||.|| .| .|.|.|.|||| ..| . |.. ..  |.   . .| |......... ..  |.|.... |||.|||.... .|...... . .      |
iVmltnleeldktkyhkywPdegke.tygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkp

LVIHCSAGVGRTGTYIAIDRLCNAAEDMHpMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAIDRG
....|||||||.||.|||| . . ..  . ..  ..||  .||.|  .|||  || |.| | |.|.| .
vivqCsaGvgRsGtfiaidsvlervkkeq.vvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf
subfamily_PTPRG_pd Subfamily PTPRG 57-320 2.1e-71 235.8 In-house 19-290 (563) alignment 
Range on Protein: 57-320
Range on HMM: 19-290/563.0
QGWQMEYGGL--APIGTDQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNN-DYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGL
.|.. |.  |    | .| .||.|..|||  .|||.||||||.|||...|   .|.. ||||||.. ||.  ||.|| |||..| |  ||.||||| | .
igfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvai

IVMITNEVEAGKLKCHRYWPDpNSELRVGNFVIKSISEVARTSFIERHFELTDQ------TSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHD
|||||| || |. ||..|||  .  ...|.. .. |.|   ..  .|.. . .          .   |.| .|  |||||||. .   |.|     .|. 
ivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaank

P-RTPLVIHCSAGVGRTGTYIAIDRLCNAAEDMHpMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAIDRG
    |.|.|||||||||||||..| | .  .. . .    ...  .|  |||||||  || |.. |||.||  .
aeaGPivvHcsaGvgrtGtyivldtllkqiqqen.avnvfgflkhiraqRnflvqteEqYiflhdalleaiask
0039614 (Phosphotyrosine protein) phosphatases II 58-320 3.7e-79 261.6 In-house 33-292 (297) alignment 
Range on Protein: 58-320
Range on HMM: 33-292/297.0
GWQMEYGGLAPIGTDqpAEASKRPENVTQNRYINIVAYDHSRVTVKPSEAT-KNNDYINANWVPGYKG-DKAYIACQGPVPDAFAAFWQMIWEQAVGLIV
....|.  |  .  |   . ...|||.. |||..|..|||||| .|| . .  ..|||||..|.||.  ....||.||| |. .. ||.|.||| |  ||
llllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtviv

MITNEVEAGKlKCHRYWPDPNSelRVGNFVIKSISEVARTSFIERHFELTDqtSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHD---PRTPL
|.|..|| |. ||..|||.  .  . |.|... ...  .  .. |..|.|.  .|..  |...||. |||||||.....||.| ... .|.    . .| 
mLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpv

VIHCSAGVGRTGTYIAIDRLCNAAeDMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAIDRG
..|||||||||||.||......   . .  . . ..|.|.|. |.  |||. || |.| |||. . |.
lVHCsaGvgRtGtfiaaylmleql.ekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_PTPN13_pd Subfamily PTPN13 59-317 5.9e-70 230.7 In-house 13-269 (273) alignment 
Range on Protein: 59-317
Range on HMM: 13-269/273.0
WQMEYGGLAPIGTDQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEAtknndYINANWVPGYKGDK--AYIACQGPVPDAFAAFWQMIWEQAVGLIVM
 . |.  |  . . . .| .|. || ..||| |.. ||..||... . .     ||||...    |..   |||||||.|.. . ||||.||| . .|.|
PaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviam

ITNEVEAGKLKCHRYWPDP-NSELRVGN-FVIKSISEVARTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDPRTPLVI
.|.|.| ||.|||||||.  |..| | | . .. .  . . .|  |.....|. ||..  |...... |||||||... .||.|  |. | .. ..|.|.
vtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivv

HCSAGVGRTGTYIAIDRLCNAAEDMHpMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAI
|||||.||.||.|.|| . .  |  .  .. ...| ..|. |. .|||  || ||| |.|...
hcsaGiGrsGtlitidvvlglierdk.efdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 59-321 3.1e-69 228.5 In-house 25-287 (319) alignment 
Range on Protein: 59-321
Range on HMM: 25-287/319.0
WQMEYGGLAPIGTDqPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMIT
 . |.  |   ..|   . ....|| ..||| ||.|||..||.... . ... |||||... ||.  ...|| |.|. ...  ||.|.||. .  .||.|
lekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmlt

NEVEAGKLKCHRYWPDPNSElRVGNFVIKSISEVARTSFIERHFELTDQTSGQ-TVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDP--RTPLVIH
. || .|.|...|||. | | . |.....  .|     .| |...|  ..|   |  |.. ||  ||||.||.... ||..  .| ....     |.|.|
klveklkvklkkywpeenfe.eyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvh

CSAGVGRTGTYIAIDRLCNAAEDmHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAIDRGL
||||||||||.|..|   .  .    .|    .| ..|  ||..||.  || |.| |||.|.. | 
CsaGvGRtGtfivldamlervke.egvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_PTPN14_pd Subfamily PTPN14 60-318 2e-59 196.1 In-house 26-297 (300) alignment 
Range on Protein: 60-318
Range on HMM: 26-297/300.0
QMEYGGLAPIGTDQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATkNNDYINANWVPGYKG--DKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMI
 .||  ...  .|   ...| |||. .||. ... |...|| ..|.. . ...||||  .    |  .. ||..|||.. .   ||||.||| | ||||.
fteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml

TNEVEAGKLKCHRYWPDP---NSELRVGNFVIKSISEVARTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIY----------R
|.| | || |...|.|.    ..... |.| . .      .|.| . ..|    |..   |  .||. |||||||.  .. |.. .|.            
teeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

AHDPRTPLVIHCSAGVGRTGTYIAIDRLCNAAEdMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAID
... . |...||||||||||  |  | | .. |     .  . |.| .|. | .||||| || ||| .|.  ..
skeskPPvlvhCsaGvGrtGvlilsdlliatle.hneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 60-316 6.3e-26 86.0 In-house 9-258 (267) alignment 
Range on Protein: 60-316
Range on HMM: 9-258/267.0
QMEYGGLAPIGTDQPAEASKRP-ENVTQNRYINIVAYDHSRVTVKpseaTKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMIT
. |.  .  | ...   .   . .|  .||. . . ||..|| ..    ||...|||| .| |||  .|.|. |.|.  . . |...| .| |  ||..|
ekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilr....tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivllt

NeVEAGklKCHRYWPDP-NSELRVGNFVIKSISEVARTSFIERHFELTDQTSgQTVPVQQMQYILWPDHGVPNT-TRDLLNFRDeIYRAHDPRTPLVIHC
. |  .  . ...||       .  .....   |     .    .||  .    .  |    |  |      .   . |.       .  .   |||..|
k.vftd..nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkne.sahnvtlyyykkwnintnnkpylkplfgila.knqlengnrPlvvac

SAGVGRTGTYIAIDRLCNAAEDmHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDA
|.||||.||.. ||   . |     ...  | . ..|. |  ||.|. .| ...  | . 
sdGvGrsGtflvidsqlerakt.egvsdifdflrkirsqriglvdtkeryiyihellaey
0046845 (Phosphotyrosine protein) phosphatases II 62-320 2.6e-83 275.0 In-house 5-277 (284) alignment 
Range on Protein: 62-320
Range on HMM: 5-277/284.0
EYGGLAPIGTDQ--PAEASKRPENVTQNRYINIVAYDHSRVTVKPSEAT-KNNDYINANWVPGY-----KGDKAYIACQGPVPDAFAAFWQMIWEQAVGL
|.  |  . ...  . .....|||.. ||| .|..|||||| .|. . . ...|||||..|.||     .  |..||.|||.|. .. ||.|.||| | .
efeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrv

IVMITNEVEAGKLKCHRYWPDPNSELRVGNFVIKSISEVARTSFIERHFELTDQT-SGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDP---R
|||.|..|| |. ||..|||. .. |. |.| .. .||  . ... |..|||.   .|... |....|. ||||||| ...|||.| ... ....     
IVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgg

TPLVIHCSAGVGRTGTYIAIDRLCNAAEDMHP--MLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAIDRG
 | |.|||||||||||.||.| |..  |  ..  .. . ..|. .|. |.. |||| || ||| |||... ..
gpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
subfamily_PTPRA_pd Subfamily PTPRA 63-317 2.1e-60 199.3 In-house 38-295 (330) alignment 
Range on Protein: 63-317
Range on HMM: 38-295/330.0
YGGLAPIGTDQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVE
.  |     .   |.... ||  .||..||. ||.||| . . | ... ||||| .. |||  . .||.|||  ..   ||.|||||    |||.|.  |
fnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelke

AGKLKCHRYWPDPNSeLRVGNFVIKSISEVARTSFIERHFELT---DQT-SGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDP-RTPLVIHCS
  . ||..||||  . .  ||  ..   |.   ..  |.| ..   |.|   ..  |.|. .  ||| ||| ... .|..  .. . ..    |.|.|||
rkeekcaqywPdeGl.vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcs

AGVGRTGTYIAIDRLCNAAEdMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAI
||||||||.|..| . .  .    ..   ..| ..|. |  .|||. || |.| .||.  
aGvGrtGtfivldavlervk.aerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_PTPRN_pd Subfamily PTPRN 64-317 8.8e-56 183.8 In-house 36-292 (297) alignment 
Range on Protein: 64-317
Range on HMM: 36-292/297.0
GGLAPIGTDQP-AEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKG-DKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEV
 .|.   ...  .|..|...||..||. ....||||||..| . .....|||||  .        ||||.|||...  |.||||.||| | .||..|.  
ealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrle

EAGKLKCHRYWPDPNSELRvGNFVIKSISEV-ARTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDPR-TPLVIHCSAG
| |  .|.|||||  ||.  . . .. .||      .. | | | .  . .|  | |. .. ||..||| ... ||.||  . ...  | .|.|.|||.|
eegvkqckrywpdeGsevy.hiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdG

VGRTGTYIAIDRLCNAAEDMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAI
.||||.||.|| ..|        .     .  .|  |. ||.|  |. |.. |. . .
aGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 65-121 1.4e-10 35.1 In-house 29-85 (440) alignment 
Range on Protein: 65-121
Range on HMM: 29-85/440.0
GLAPIGTDQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPG
 | | |  ||.. .  |.|  .||| ||.||||||| ..  ..  ..||||| .. |
sllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 68-315 5.6e-39 128.5 In-house 39-281 (290) alignment 
Range on Protein: 68-315
Range on HMM: 39-281/290.0
PIGTDQPAEASKRPENV--TQNRYINIVAYDHSRVTVKPSeatKNNDYINANWVPGYKgdKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGK
|    |. | .   .|   ..||| ..|  | .|| .|      . ||. ||.| | |    .|  ||.. |.   .|.|. .. |  |||. . .| ||
pylpvqylerkifdkntefkknrykdvvcndktrvilkdG...ydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGk

LKCHRYWPDPNSE-LRVGNFVIK-SISEVARTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIyraHDPRTPLVIHCSAGVGRT
 ||..|.|. . | |  |.. .  | ..   .  | . . . |. ||.   .. .. . |||. |...|  ||     .        |.|.|||||.|||
akceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril...rkasGpvvvhcsaGiGrt

GTYIAIDRLCNAAEDMHpMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLD
||..||.   .   | .  |.. |.|  .|.||   ||  .||  .  .|||
GtfvaievglqilldGk.eldlldlvralrnsrlnsvqvdiqylalveilld
DSPc_SM00195 70-317 8.9e-78 256.6 In-house 13-262 (263) alignment 
Range on Protein: 70-317
Range on HMM: 13-262/263.0
GTDQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCH
 .... . .....|...||| ||. |||.|| .|..| ....||||||.. |.. .|.|||.||| |. .. ||.|.||. | .|||.|.|.| || ||.
tspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcd

RYWPDP-NSELRVGNFVIKSISEVART-SFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDP-RTPLVIHCSAGVGRTGTY
||||.  ... ..|.. .| ...  .  ..| |..||| ..  .|  |.|.||  |||||||..|...|..  ...  ..   .|.|.|||||||||||.
rywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtf

IAIDRLCNAAEDMHPmLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAI
..|| ...  |. .  .   ..| |.||.|  .|||| || |.| |.|..|
vtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 70-317 8.9e-78 256.6 In-house 13-262 (263) alignment 
Range on Protein: 70-317
Range on HMM: 13-262/263.0
GTDQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCH
 .... . .....|...||| ||. |||.|| .|..| ....||||||.. |.. .|.|||.||| |. .. ||.|.||. | .|||.|.|.| || ||.
tspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcd

RYWPDP-NSELRVGNFVIKSISEVART-SFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDP-RTPLVIHCSAGVGRTGTY
||||.  ... ..|.. .| ...  .  ..| |..||| ..  .|  |.|.||  |||||||..|...|..  ...  ..   .|.|.|||||||||||.
rywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtf

IAIDRLCNAAEDMHPmLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAI
..|| ...  |. .  .   ..| |.||.|  .|||| || |.| |.|..|
vtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0045098 (Phosphotyrosine protein) phosphatases II 70-318 1.7e-75 249.3 In-house 20-273 (278) alignment 
Range on Protein: 70-318
Range on HMM: 20-273/278.0
GTDQPAEASKRPENVTQNRYINIVAYDHSRVTvkpseatknnDYINANWVPGYkgDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCH
|  .  . . ...|.  ||| .|..||||||           |||||....||  .|..||.||| |. .|.||.|.||. .  |||.|..|| |. ||.
gipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekca

RYWPDpNSELRVGNFVIKSISEVARTSFIERHFELTDQ----TSGQTVPVQQMQYILWPDHGVPNTT--RDLLNFRDEIYRAHD--------------PR
.|||. .. |. |.|... .||     .. |....|.     .....  |....|. |||||||...  . .|.. ..| .|..              . 
qywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg

TPLVIHCSAGVGRTGTYIAIDRLCNAAedmHPMLHPRDVVAEMRKSRNF-LVQTLVQYGFVYLALLDAID
.| ..|||||||||||..|.. ..      .. . . ..|.|.|. |..  ||.| || |.| .||. . 
gpvlVHCsaGvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPN1_pd Subfamily PTPN1 70-317 8.4e-60 196.9 In-house 19-271 (290) alignment 
Range on Protein: 70-317
Range on HMM: 19-271/290.0
GTDQPAEASKRPENVTQNRYINIVAYDHSRVTVKpseaTKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCH
 .| |....|.||| ..||| ..  |||||....     ..||||||. |   . .. ||  |||.|.. . ||||.|||    .||. . || ...||.
asdfptreaklpenrnlnryrdvspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikca

RYWPDPNS--ELRVG--NFVIKSISEVARTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRA---HDPRTPLVIHCSAGVGR
.|||  ..  || .   .. .| |||  .  .. |..||..... .|  . .. |. ||| |||..   .|.|  .. ..    .   | |||||||.||
qywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGr

TGTYIAIDRLCNAAEDMHP--MLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAI
.||.. .| .    |. .    .. ..|. |.|| |  |.||  |  | |||.|. .
sGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGa
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 70-313 3e-42 139.3 In-house 27-289 (301) alignment 
Range on Protein: 70-313
Range on HMM: 27-289/301.0
GTDQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEA--TKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLK
|.|.... . . || . ||. ||. ||. |...|| ..  .....||||... ||.  |..|| |||.    . ||..||.. .  |||.||. |  | |
gedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtksk

CHRYWPDPNSE-LRV-------------GNFVIKSIS----EVARTSFIERHFELTDQTsgQTVPVQQMQYILWPDHGV-PNTTRDLLNFRDEIYRAHDP
|..|||. . |  ..              .|||....    ...  ..|||.|. . .   ..  | |.| . ||..|| ..    |    | |.| . .
ceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqki

-RTPLVIHCSAGVGRTGTYIAIDRLCNAAeDMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLAL
   |.|.|||..|.|.|.|....     .          .|.  .|.|.   |.|| || ..| ..
gggpvvVHCSdtVsrsGvYcsvsiglEQc.kaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi
subfamily_ptpA1_pd Subfamily ptpA1 70-268 8.2e-38 125.2 In-house 35-248 (418) alignment 
Range on Protein: 70-268
Range on HMM: 35-248/418.0
GTDQPAEASKRpENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKgDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCH
|  . .|  |.  | ..||| ||.  .|.|| .|  .  . .||||||.. |    | .|. |||.|.. | ||.|.||. . .|||.. | |  ..|| 
gpsetsegdkk.hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcd

RYWPDPN-----SELRVGNFVIKSIS----EVA---RTSFIERHFELTdqTSGQTVPVQQMQYILWPDHGVPNTTR---DLL----NFRDEIYRAHDPRT
||||.       |    || |. . |    ||        | |   ||    |.|  . | ||  |||| .|. |.   .||    | ...|  . |   
rywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirlt..fegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnv

PLVIHCSAGVGRTGTYIA
|...|||||||||||. .
piivhcsagvgrtgtfct
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 72-320 8.5e-43 141.2 In-house 22-269 (283) alignment 
Range on Protein: 72-320
Range on HMM: 22-269/283.0
DQPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEAtknnDYINANWVP---GYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKC
|..|. .   || ..||. .||..|  || .|.       ||||| ..|    || || ||..|.|. ..   ||.|.... .  |||.|.  |  . ||
dldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikC

HRYWPDPNSElRVGNFVIKSISEVARTSFIERHFELTDQTSG-QTVPVQQMQYILWPDHGVPNTTRDLLNFRDEI-YRAHDPRTPLVIHCSAGVGRTGTY
 .|||   ||   |.| .    |..  ||| . . |  ..|  .|. .   |.| | . |       |..|   |  . . ...|.|.|||.|.|||...
sqyWPkrGse.dyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavf

IAIDRLCNAAEdMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAIDRG
||.    . |   . ..    ||  ||. |  .|||| || .|. . |.    |
iaasasvkdal.tesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcg
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 73-317 2.4e-57 189.3 In-house 41-284 (297) alignment 
Range on Protein: 73-317
Range on HMM: 41-284/297.0
QPAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGdkAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKlKCHRYW
||.  ...  |  ..|| ||. || |||...  .   . ||.|| .|.|.|    .|. | | ... | ||.|.... |  |||.... |  | || |||
qpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryW

PDPNSeLRVGNFVIKSISEVARTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPN--TTRDLLNFRDEIYRAHDPR--TPLVIHCSAGVGRTGTYIA
.|  .    |. ...  |   |. ||.|..|.| . . ..  |.| |.. |||. |..  ... ||.. .|.   .. .  .||..||.||||||| ...
sdkgv.ttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvllt

IDRLCNAAEDMHpMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAI
||     |.. .  .   ..|  .|..| .||||  || ||| |.|.|.
idsvvaeakrek.evdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_PTPN12_pd Subfamily PTPN12 74-325 2.6e-71 234.8 In-house 31-285 (290) alignment 
Range on Protein: 74-325
Range on HMM: 31-285/290.0
PAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWP
..||....|||..||| .|. ||.|||...  | ....||||||.. | .|...||| |||.|..   ||.||||. | ..||. .||| || ||.||||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

DP-NSELRVGNFVIKSISEVART-SFIERHFELTDQtsGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAH-DPRTPLVIHCSAGVGRTGTYIAID
.  ..||..|.| .. ..| | .  |. | .... |  ...  |.|..|  |||||||... .||.. ... . . .  .|||.||||||||||| ||||
eegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaid

RLCNA--AEDMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAIDRGLGQAK
   ..  || . . |.  |.|.|.|| |. ||||  || .|| |... . . |.. .
yvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiie
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 74-317 7.7e-57 187.5 In-house 35-277 (315) alignment 
Range on Protein: 74-317
Range on HMM: 35-277/315.0
PAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWP
.  ... ..| ..||| ||. .|..|| ..  . . ..|||||  ..... |||||| ||| . .   ||.|.... |  |||.|.  |  |.|| .|||
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

D-PNSELRVGNFVIKSISEVARTSFIERHFelTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDPRT-PLVIHCSAGVGRTGTYIAIDR
|      . |.. .. .|  | |  . |..  . . | ..  | | |.  |||.||.. |  ||..  |.   ..... .|..||||||||||  |.|| 
drkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvviside

LCNAAEDmHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAI
  . ...   ..   ..| ..|. | .||||  .| |.| |.|. .
vvaqikr.trsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 74-316 4.5e-46 152.0 In-house 36-235 (392) alignment 
Range on Protein: 74-316
Range on HMM: 36-235/392.0
PAEASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGklkchrywp
|  ..... |. .||| ||. || .|| ..  . . ..||.|| ..|... .|||||.||| . ..  ||.|.... |  |.|.|.  |.          
pqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........

dpnselrvgnfviksisevartsfierhfeltdqtS-GQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDPRT-PLVIHCSAGVGRTGTYIAIDR
                                      ..  | | ..  |||..||. |  ||.|  |.   .   | ||.|||||||||||  |.|| 
...................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisids

LCNAAEDMhPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDA
.   |.    |.   ..|...|. | ..|||  || |.| |.|. 
vvahakkt.rmvdvfnfvtnirrkrpymvqtkeqyafiygavled
subfamily_PTPN3_pd Subfamily PTPN3 75-317 3.3e-75 247.6 In-house 33-275 (280) alignment 
Range on Protein: 75-317
Range on HMM: 33-275/280.0
AEASKRPENVTQNRYINIVAYDHSRVTVKPSEAtknnDYINANWV----PGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHR
 .|...|||...||| .|..||. ||..| ||.    ||||||.|    |. .  . |||.|||.... . ||||.||| . ||||.|. || |. |||.
isaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChq

YWPDPNSELRVGNFVIKSISEVARTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAH-DPRTPLVIHCSAGVGRTGTYIAI
|||... ||. |.| .|  .| ...|.. |.. |.|... .  .. |.||. |||||||. . |.|.| ... ...   ..|.|.|||||.|||| .|..
yWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlill

DRLCNAAEDMHPmLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAI
.      |  .| ..| |.| .||  |  ||||  || ||  |.| . 
etalalieaaep.vypldivrtmrdqramlvqtasqykfvCeailkvy
0040439 (Phosphotyrosine protein) phosphatases II 76-316 9.5e-75 246.7 In-house 4-245 (249) alignment 
Range on Protein: 76-316
Range on HMM: 4-245/249.0
EASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDp
. ...|||.  ||| .|..|||||| ... .    .|||||....||.  ...||.||| |.....||.|.||. .. |||.|..|| |. ||..|||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

NSELRVGNFVIKSISEVARTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHD---PRTPLVIHCSAGVGRTGTYIAIDRL
...| .|.|... .|.    ... |..|||.   |... |...||. ||||||| .. |||.| ...  |..   . .|...|||||||||||.||.. .
ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

CNAAEdMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDA
..  |  .  . . ..|...|. |.  ||.. || |.| |||. 
leqle.kelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_PTPN6_pd Subfamily PTPN6 76-318 2.3e-70 232.0 In-house 47-298 (306) alignment 
Range on Protein: 76-318
Range on HMM: 47-298/306.0
EASKRPENVTQNRYINIVAYDHSRVTVKpSEATKNNDYINANWVPG--YKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWP
. ...||| ..||| ||. .||.||..| .. ....|||||| . .   . ||.||| || ...  . ||.|.|..   .|||.|.||| || || ||||
kegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWP

DPNSELRVGNFVIKSISEVARTSFIERHFELTD-QTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDPRT-----PLVIHCSAGVGRTGTYI
| ... . |.  ....|| . ...| |.. ..  ......  | |...  |||||||. .  .|.| ... | ..  .     |.|.|||||.|||||.|
deeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfi

AIDRLCNAAED--MHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAID
 || | .  |   ..  .  ...|  .|. |. ||||  || ||| |.   |.
viDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 76-316 1.2e-59 197.2 In-house 54-290 (319) alignment 
Range on Protein: 76-316
Range on HMM: 54-290/319.0
EASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITneveagKLKCHRYWPDP
. .  ..|  .||.|||.|.|...| ... .     ||||| .| ||.  . |||.||| ... | ||.||||. .  ||..|      | || .|||  
tfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplk

NsELRVGNFVIKSISEVARTSFIERHFELTDQ-TSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDE---IYRAHDPRTPLVIHCSAGVGRTGTYIAIDR
  . . ..| .|  |      .. |..||...    .   ..|  .  |||.|||. . ||. . .    . .  . |...|.||||||||||.||..| 
i.vikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldv

LCNAAEDmHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDA
| .  ..   ..   ..| ..|. || ||| |||| |.| |||. 
lldrmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 76-315 7e-56 184.3 In-house 21-266 (274) alignment 
Range on Protein: 76-315
Range on HMM: 21-266/274.0
EASKRPENVTQNRYINIVAYDHSRVTVKPSEATKN-NDYINANWVPGYKG-DKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWP
|  . . . |.||| .|.  ..|||..........  .|||||.. ||.. .|||.| |||.| . | ||.||... | .|||.|.  || . ||..|.|
eeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP

DPNSE---LRVGNFVIKSISEVARTSFIERHFELTDQTSGQTvpVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHD----PRTPLVIHCSAGVGRTGTY
| ..     | |.. ||  . | |  .  |.. |  ... ..  |. . |  |||| .|. .. ||.. .|. ....    ...| |.|||||.|||| .
daedyeiserygdveikvekiverndysvrklvlkylerers..vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcf

IAIDRLCNAAEDMhPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLD
|||.  ..  ..   ..    .|...|  |  .|||  || ... ||  
iaisiavrqlree.ivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 76-314 7.5e-50 164.3 In-house 1-238 (239) alignment 
Range on Protein: 76-314
Range on HMM: 1-238/239.0
EASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGD-KAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPD
||.|.  | ..||| |||.|||||| ..       .|||||...  | |  ||||| || |  .   ||.|.|..   .|||.|  .|  | |||.||||
eaakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

PNSELRVGNFVIKsISEVArTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDPR-TPLVIHCSAGVGRTGTYIAIDRLC
  |.       ..  .||  . .| | | ...    .   | | .. .|||.|||. .  .| .| .| .   |   | ||||||||||||... || . 
stskycnlrvtlr.ktevf.adyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml

NAAEDMHpMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALL
  |.  .  .   . |  .|. | ..|||  || |..||.|
rqakkqk.tvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_egg_pd Subfamily egg 76-325 2.7e-20 67.3 In-house 33-278 (307) alignment 
Range on Protein: 76-325
Range on HMM: 33-278/307.0
EASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAgkLKCHRYWPDP
. .   .| .. |   .   | |||...  .    .|.| || | |      .| .| |. ..   ||.|.... |  |||.|  .|.   .|. |||  
ttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpka

NS-ELRV--GNFVIKSISEVARTsfiERHFELTDQTS-GQTvpvQQMQYILWPDHGVPNTtRDLLNFRDEIYRAHDPRTPLVIHCSAGVGRTGTYIAIDR
.|  |..  |.. |...    ..   .  | .|     |     .. ...      | |.  |.      . .. .  .| |...  || ...| .||. 
esdslvtvpGslrienlkvdska...dplfrvtklklvGgd...deerflehwqgdvnns.sdvysplrvlrklrnlskpvvvqdilGvskaatlvaiei

-LCNAAEDMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAIDRGLGQAK
 |..           .  |  .|. |.. |.. ..| |||  .|  .   .| ||
allsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsak
0037934 (Phosphotyrosine protein) phosphatases II 77-314 9e-69 227.0 In-house 4-239 (243) alignment 
Range on Protein: 77-314
Range on HMM: 4-239/243.0
ASKRPENVTQNRYINIVAYDHSRVTVkpseatKNNDYINANWVPGYKGdkaYIACQGPVPDAFAA----FWQMIWEQAVGLIVMITNEVEAGKLKCHRYW
 ...|||.. ||| .|..|||||| .      ...||||||.......   .||.||| |. ..     ||.|.||. .. |||.|..|| |..||..||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PdpNSElRVGNFVIKSISEVARTSFIERHFELTDQT-SGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYR---------AHDPRTPLVIHCSAGVGR
|  ... . |.|... .||    ... |...|.    ...|  |.. .|. |||||||... |||.| ||..          | |.  |...||||||||
p..gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGTYIAIDRLCNAAedmhpMLHPRDVVAEMRKSRNF-LVQTLVQYGFVYLALL
|||.||.. ..         . . ..|...|. |..  |||. || |.| |||
tGtliaaylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 77-316 7.7e-59 194.5 In-house 19-254 (284) alignment 
Range on Protein: 77-316
Range on HMM: 19-254/284.0
ASKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITneveagKLKCHRYWPDPN
 .  ..|  .||...|.|.|...| ...       ||||| .. ||.  . |||.||| ... | ||.||||. .  ||..|      | || .|||   
fanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplki

sELRVGNFVIKSISEVARTSFIERHFELTDQ-TSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDE---IYRAHDPRTPLVIHCSAGVGRTGTYIAIDRL
 . . ..| .|  |      .. |..||...    .   ..|. .  |||.|||. . ||. . .    . . .. |...|.||||||||||.||..| |
.vikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvl

CNAAEDmHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDA
 .  ..   ..   ..| ..|. || ||| |||| |.| |||. 
ldrmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
0049772 (Phosphotyrosine protein) phosphatases II 77-320 5.5e-39 130.1 In-house 40-283 (314) alignment 
Range on Protein: 77-320
Range on HMM: 40-283/314.0
ASKRPENVTQNRYINIVAYDhSRVTVkPSEATKNNDYINANWVPGYkgdKAYIACQGPVPDAFAAF----------WQMI--WEQAVGLIVM--------
... ..| . |||..|. .| .|| . |..  .. |||||..| |.   ...||.||| .  .  |          |.|.  ... |  |||        
vadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------ITNEVEAGklkchrywpdpnselrvG----------NfviksisevartsfierhfelTDQTSGQ--TVPVQQMQYILWPDHGVPnT
             ...  . |                 .          .                     . .....  . .. .  .| .||...| .
elsrLdaAlgKtpllildgng.................neptaadlellk.....................eelydpelferlgikylripvpDgsap.l

TRDLLNFRDEIYRAhDPRTPLVIHCSAGVGRTGTYIAIDRLCNAAEdmhpmLHPRDVVAEMRKSRN-----FLVQTLVQYGFVYLALLDAIDRG
..|.. | . | .| |. .|...||.||.|||||..... |. .       . ........|. |       ....| || |.. |||..... 
ledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllg.....vsleealedvrlkRpinpnpgfieqleqyefilealleylkfl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 77-240 2.7e-36 119.9 In-house 27-191 (297) alignment 
Range on Protein: 77-240
Range on HMM: 27-191/297.0
ASKRPENVTQNRYINIVAYDHSRVTVKpsEATKNNDYINANWV--PGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPD
..||.  . .||| .|.|.| .|| ..   .  ..|||||..|  |  . |  ||  |||. ..   ||....|| |. |||...  | |. ||  |||.
sakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywps

PNSE-LRVGNFVIKSISEVARTsFIERH-FELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRD
 . | |. |..|.. .|...   |   .  ||.     ..  |. .|.. |||||||.   ||  |. 
vvqerlkagdvvveflsstsde.fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqa
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 77-315 2.8e-34 113.1 In-house 31-267 (281) alignment 
Range on Protein: 77-315
Range on HMM: 31-267/281.0
ASKRPENVTQNRYINIVAYDHSRVTVKPSEATKN-NDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDP
. ..| |  .|||.|| . | ||| .|     ||  ||| ||..      . ||  |||  .. | ||.|||..    |||. . .|. . ||  |.|  
vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn

-NSELRVGNFVIKSISEVARTSFIERHFELTdqTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIyRAHdpRTPLVIHCSAGVGRTGTYIAIDRLCN
    |.. .. ..        |..  ...|.    |.|  . .  .  |||  ||...  .|.   .| ||.   || ||||||||||.|| .|..   .
ahcclqfdklsvsyedstvnkslvttrlnls..yegetrlithwlwkewpdwqvpessevmlkilrki.rar..stppvihcsagvgrsgtlmaveialq

AAEDMHPMLHPRDVVAEMRK-SRNFLVQTLVQYGFVYLALLD
.      .   ...|. .|   |   |||| || ...  |||
sihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_eak_pd Subfamily eak 77-240 8.6e-18 58.8 In-house 46-205 (332) alignment 
Range on Protein: 77-240
Range on HMM: 46-205/332.0
ASKRPENVTQNrYINIVAYDHSRVTVKPSEATkNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPN
 ..| |.| .|  ..|| ||.  | . .|    .. ||||  .   .  . ||    .  |   |||||. ||    ||.. ..|| .  |  .|.||  
etarleavnrn.vvkivpydrylvrltssqln.rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdkt

-SELRVGNFVIKSISEVARTSFIERHFELTDqtSGQTVPVQQMQYILWPDHGVPNtTRDLLNFRD
  ||. | . ..  . | |  .  | .||.     .|  |.  ..  | .  .|   .|.| .|.
reelkfGildverkefvkrniletrllelsk..GnethrvlhykvfGwtettlpk.yedflalrk
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 77-133 7.1e-10 33.0 In-house 42-95 (95) alignment 
Range on Protein: 77-133
Range on HMM: 42-95/95.0
ASKRPENVTQNRYINIVAYDHSRVTVKpseATKNNDYINANWVPGYKGDKAYIACQG
.     |. .||..||. || .||..    . .. ||||| .| ||   ..|||.||
vgsseanipknrflnifpydatrvvlt...tkrdsdyinacfvdgyarkncyiaaqg
0042113 (Phosphotyrosine protein) phosphatases II 78-316 4.1e-75 247.6 In-house 4-242 (245) alignment 
Range on Protein: 78-316
Range on HMM: 4-242/245.0
SKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDpNS
...|||.. ||| .|..|||.|| ..| .    .|||||..|.||.  . .||.||| |. ...||.|.||. .  |||.|.|.| |. ||..|||. ..
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge

ELRVGNFVIKSISEVARTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHD--PRTPLVIHCSAGVGRTGTYIAIDRLCNA
.|..|.|... .||    ... |..|.|.  ....  |....|. |||||||.....||.| ... .|    . .|...|||||||||||.||...... 
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

AEDMhPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDA
.|     . . ..|.|.|. |   |||. || |.| |||. 
leke.lgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 78-318 3.8e-67 221.1 In-house 4-243 (250) alignment 
Range on Protein: 78-318
Range on HMM: 4-243/250.0
SKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLkCHRYWPDPNS
.|.|.|  .||| .|.|.|.||| ...... |. ||||| .. ||.. ||.|| |||.....  ||.|..|. .| |||.|| .| .|  .|.|||  ..
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

ElRVGNFVIKSISEVARTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDP--RTPLVIHCSAGVGRTGTYIAIDRLCNA
| . |.  ..  |.   . .. |.. |. ..  . . |.|.... ||| |||....  |...... . ..    .|....|||||||.|..|||| . . 
e.kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

AEDMHpMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAID
..  . ..  ..|.  .|| |   |..| || ||| ..| |.|
lkkek.vvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 78-316 7.6e-50 164.3 In-house 2-239 (239) alignment 
Range on Protein: 78-316
Range on HMM: 2-239/239.0
SKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGD-KAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPN
.|.  | ..||| |||.|||||| ..       .|||||...  | |  ||||| || |  .   ||.|.|..   .|||.|  .|  | |||.||||  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

SELRVGNFVIKsISEVArTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDPR-TPLVIHCSAGVGRTGTYIAIDRLCNA
|.       ..  .||  . .| | | ...    .   | | .. .|||.|||. .  .| .| .| .   |   | ||||||||||||... || .   
skycnlrvtlr.ktevf.adyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

AEDMHpMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDA
|.  .  .   . |  .|. | ..|||  || |..||.|.|
akkqk.tvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_CG7180_pd Subfamily CG7180 78-317 2.4e-43 142.9 In-house 37-290 (296) alignment 
Range on Protein: 78-317
Range on HMM: 37-290/296.0
SKRPENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKlKCHRYWPDPNs
  | ||  .||....| ||. || ..  .  ...||||| .| ..  .|.||  ..|. ..  .||........  .|..|.. .  | ... |||    
glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.

ELRVGNFVIKSISEVARTSFIERHFELTDQ----------TSGQTVPVQQMQYILWPD-HGVPNTTRDLLNFRDEI--YRAH----DPRTPLVIHCSAGV
. . |..... ..|   . .  | | || .           . .|  |...|.  |.  . ||  |  |...|  .  .| .    . . |.|...| |.
keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGa

GRTGTYIAIDRLCNAAEDmHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAI
.|.| |.|||   . .|  .  .   . |  .|.||. ||..  .| ..|  ||.|.
sRsGvylaidanlelvek.eeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 79-213 1.7e-12 41.5 In-house 30-163 (332) alignment 
Range on Protein: 79-213
Range on HMM: 30-163/332.0
KRPENVTQNRYINIVAYDHSRVTVKPSEAtkNNDYINANWVPGYKGDKAYIACQGPVPDAF-AAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPNS
|  .|.  ||   . ..||||| . | .   ..|. ||.|| ||    ||| .| |. |     ||.|. |.   .|... .  |  | |.     |   
kflnnmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgf

ELR-VGNFVIKSISEVARTSFIERHFElTDQTSGQTV
|   . .|  ||. |.   . | |.|   ...| . .
eksflhefgaksleecelkakicrkfw.pekrskkdf
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 81-320 1.1e-56 187.0 In-house 45-281 (287) alignment 
Range on Protein: 81-320
Range on HMM: 45-281/287.0
PENVTQNRYINIVAYDHSRVTVKpseaTKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPNSeLR
..|  .||. .|. .|  || .|     ...||||| .. ||| .||.|....|. ..   ||..|... |  |||...| |  . .|..|||. .| . 
sqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vv

VGNFVIKSISEVARTSFIERHFELTDQT-SGQTVPVQQMQYILWPDHG-VPNTTRDLLNFRdEIYRAH--DPRTPLVIHCSAGVGRTGTYIAIDRLCNAA
.|.. |. ..|   ...|||..|.. .. .|..  |.| |.  |...| |..    || .  | |...    .|..|.|||..|||.....|..   | .
lGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvie.emyktqrkrgntsivvhCsdtvGrsamfcaaattinkc

EDmHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAIDRG
.     .   .|. ..|  .   |||  || |.. ..|  .| .
kt.eGviDvfqvlksqriqkpgsvqtveqykfindivleyldsf
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 82-316 2.6e-59 195.7 In-house 42-275 (515) alignment 
Range on Protein: 82-316
Range on HMM: 42-275/515.0
ENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPD-PNSELR
 | ..||| ||. || .|| ..  .   ..||.||  .|... |||||| ||| . .   ||...... |  |.|.|.  |  | || .|||| |   ..
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

VGNFVIKSISEVARTSFIERHFELTDQTSGQTvpVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDPRT-PLVIHCSAGVGRTGTYIAIDRLCNAAEDm
 |.. .. .|  | |  | |..... .   .|  | | ..  |||.|||. |. || .  |.   |.  | ||.||||||||||| .|.||     |.. 
fGsikvelvsleactggikrkltvlkgddsrt..vtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakt.

HPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDA
  |.   ..|  .|. | .||||  || |.| |.|. 
trmvdvfnfvtnirqkrpylvqtqeqyafiygavled
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 82-315 1.5e-57 189.6 In-house 19-262 (270) alignment 
Range on Protein: 82-315
Range on HMM: 19-262/270.0
ENVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGD-KAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPNSE--
 . . ||| .|.   ..||.... | ...  |||||.|.|..|. |.||| .||.| .  .||.||||. |  |||.|. .| |. || ||||  . |  
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

-LRVGNFVIKSISEVARTSFIERHFELTdqTSGQTVPVQQMQYILWPDHGVPNTTR------DLLNFRDEIYR---AHDPRTPLVIHCSAGVGRTGTYIA
 |. |.  . ..||. .. .| .. .|.  ..|..  .   .|  |||||||...       .||.   .. |    .|  .||..||||||||||| ||
kledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IDRLCNAAEdMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLD
.|  ... | ..  . .  ...|.|| |  |||. .|| |.| |.. 
lDiavrlLe.etkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 82-314 4.3e-56 184.8 In-house 37-274 (287) alignment 
Range on Protein: 82-314
Range on HMM: 37-274/287.0
ENVTQNRYINIVAYDHSRVTVKpSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPNSELRV
 .| .||| ... .|..|| .   |. .  ||||||.|..|. |.|.||.|||.. .   ||....|. .  ....| ||| ..|||..|||...  .||
aavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrv

GNFVIKSISEVA-RTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNT----TRDLLNF--RDEIYRAHDPRTPLVIHCSAGVGRTGTYIAIDRLCN
| . .  ..       .  | . | |  . ..  |.|.... |||.... |     |  |.   . |. |  .   |||.|...|.||.|...|.  | .
GGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvs

AAEDMHpMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALL
  ||.   . .  ||. .|. |. |||. ||. ..| || 
rledlG.rvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 82-314 4.8e-52 171.6 In-house 2-236 (237) alignment 
Range on Protein: 82-314
Range on HMM: 2-236/237.0
ENVTQNRYINIVAYDHSRVTVKPseATKNNDYINANWVPGYKG-DKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPNSELR
||  .||| |||||||||| .|   |  . |||||... |. |  | |||.|||.  .   ||||.|..   .|||.|  .|  .||||.|||. .    
enkiknrygnivaydhsrvvlkg..agsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

VGNFVIKSISEVARTSFIERHFELTDQTSGQTVP-VQQMQYILWPDHGVPNTTRDLLNFRDEIYR--AH-DPRTPLVIHCSAGVGRTGTYIAIDRLCNAA
 | . .    . . . .  | . |. ... . |  ..| |.  |||.|||. |  || || .|     |    .| .||||||||||| .. || .   |
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

EDMHpMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALL
.. . ..   . |  . . | ...||  || |.. ..|
kekk.vvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 82-315 3.3e-37 123.1 In-house 40-275 (307) alignment 
Range on Protein: 82-315
Range on HMM: 40-275/307.0
ENVTQNRYINIVAYDHSRVTVKPSEAtkNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPNSELRV
 |  .||| .. . |..|. || . .    ||| ||..      | .|..|||  ..   || |. .. |  ..|. . .| .|.||..|||  . .  |
antdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklv

GNFVIKSI--S--EVARTSFIERHFELT---DQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIyraHDPRTPLVIHCSAGVGRTGTYIAIDRLCN
     ..|  .   . . .  |   ..|    . ....  .|..|.  |||.|||..    .|. . .   .  . |.|.||||||||.|| .||  . .
fgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleav...rydtnpvvvhcsaGvGrsGtivaislvqd

AAEDMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLD
   .       ...| |.|. |.. .|| .|| ...  ||.
kmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 82-314 5.7e-28 92.8 In-house 42-268 (288) alignment 
Range on Protein: 82-314
Range on HMM: 42-268/288.0
ENVTQNRYINIVAYDHSRVTVKpseaTKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPNS-ELR
.| |..|| |.   | .|| ..       . ||.|| |.  | ..  | .| |.  .   .|.|. |. |  |||... .| || |   |.|     . |
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

VGNFviKSISEVARtSFIERHFELTD---QTSGQ-TVPVQQMQYILWPDHGVPNTTRDLLNFRDEIyraHDPRTPLVIHCSAGVGRTGTYIAIDRLCNAA
.| .   ..  . | . |..  ...    .  |. .| |... .  |.|.|||.     |.. . .   .. . |.|.|.||||||||| | |    ...
igrl..ctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl...kslqkPivvhssaGvGrtgtlililialesl

eDMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALL
  ..  |  | ..|..|..|   .||  || .|.  .|
.rlddflgirsllaklreerfkaiqtemqylyvhrcvl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 82-314 2.2e-27 90.4 In-house 51-287 (310) alignment 
Range on Protein: 82-314
Range on HMM: 51-287/310.0
ENVTQNRYINIVAYDHSRVTVKPsEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPN-----
... .||| ..|  | ||| .|  . .. .||| ||.|      ...| .|||.  .   ||.||...    |... . .| |. ||  |||        
kymhknrysdvvcldtsrvklki.dksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

SELRVGNFVIKS----ISEVArTSFIERHFELTDQTSG-QTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHdprTPLVIHCSAGVGRTGTYIAIDR
  .|| |.   |    | ..|  .|.     . .| .  . . |. ...  ||| |||.     .  |      |    | |.|||||..|... .|.. 
gcirvtnlsesseefeicnla.vtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh...gpcvvhcsagkdrlyvvvalkl

LCNAAeDMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALL
  . . |    ..  .|..|..|||   .|| .|| ..    .
kidkl.drglkvdaeevktellksraiciqtelqyliidrvri
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 82-176 5.7e-24 79.5 In-house 46-154 (350) alignment 
Range on Protein: 82-176
Range on HMM: 46-154/350.0
ENVTQNRYINIVAYDHSRVTVK----PSE----ATKNNDYINANWVP----GYK--GDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLK
|  ..||| ||. |.|||| .|    .|.    ... |||||||..     . .   |  ||| |.|.| ..  |...| .  | .|...|..|| .  |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CHRYWPDPN
|.|||.. .
cyrYWqegs
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 82-320 8.9e-19 62.2 In-house 46-283 (303) alignment 
Range on Protein: 82-320
Range on HMM: 46-283/303.0
ENVTQNRYINIVAYDHSRVTVKPSeatknnDYINANWVPgYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPNSELRV
.|. .||.....  |||.| .  |       || |...   . .|  |  | |.. . | ||||| || |  ....  . |  ||  .  .|  .  |. 
knmdknrfvdvicldhskvklsds......syihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GNFVIKsISEVARTSFIERH-FELTDQTSGQTV-PVQQMQYILWPDHGVPNT-----TRDLLNFrDEIYRAHDPRTPLVIHCSAGVGRTGTYIAIDRLCN
 . .|. . |  |  . .   . .   . |.    ..  .|  ||   .|.       ... .  . . | . . || |    .|.||.||.  ..    
eersir.vgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwql.qsvlrkysdstptvymslsgcgragtfalfetahl

AAEDMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAI-DRG
.  .  . |.   ..  .|. |   || | |. .||  | . . | |
slhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldng
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 82-176 1.7e-16 54.5 In-house 47-157 (349) alignment 
Range on Protein: 82-176
Range on HMM: 47-157/349.0
ENVTQNRYINIVAYDHSRVTVKP--------------SEATKNNDYINANWV--PGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGK
|  ..||| .|. |.|||| .|               |...| .||||||..  . .. .| ||| | |.| .   |...|  . | |.. .... | . 
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl

LKCHRYWPDPN
 ||..|| . .
ekcdiywqels
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 82-315 3.8e-13 43.5 In-house 50-283 (302) alignment 
Range on Protein: 82-315
Range on HMM: 50-283/302.0
ENVTQNRYINIVAYDHSRVTVKpseaTKNNDYINANWVPGYKGDKAYIACQGPVPDAF---AAFWQMIWEQAVGLIVMITNEVEAGKlKCHRYWPD-PNS
.|. .|.  .. ..|. .| ..    .....|.||  |   .  .  |  | |. |     . ||.|.... .  .|..  | |  |   . ..|   ..
knlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

ELRVGNFVI--KSISEVARTSfIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEI-YRAHDPRTPLVIHCSAGVGRTGTYIAIDRLCN
 .  |.. .  . ....  .   .   |.  .   ..| ..      |... ||    .| .   ..  .  .   ..||    |.|| |. ..     .
ykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavave

AAEDMhPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLD
  ..     .  ..|. .|. |   |..| || ..|.||| 
klqkg.kepnikeivksiRsqRpravdslkQyvslyialll
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 82-159 2.1e-07 24.8 In-house 36-118 (347) alignment 
Range on Protein: 82-159
Range on HMM: 36-118/347.0
ENVTQNRYINIVAYDHSRVTVKPSE-----ATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITN
 ....||  .    | .|| . | .     | . . ||||  .   . .| ||  | |.||.   ||.|.    |  .| | .
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 82-122 1.6e-06 21.9 In-house 38-77 (244) alignment 
Range on Protein: 82-122
Range on HMM: 38-77/244.0
ENVTQNRYINIVAYDHSRVTVKPSeATKNNDYINANWVPGY
 |.|.||||||. .|..|| .  |   . .||||||.. | 
anatknryinilpfdetrvilsss.kkegsdyinanyiqgs
Y_phosphatase Protein-tyrosine phosphatase 83-314 4.3e-70 231.2 Pfam-A 1-234 (235) alignment 
Range on Protein: 83-314
Range on HMM: 1-234/235.0
NVTQNRYINIVAYDHSRVTVkpSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWP-DPNSELRV
| ..||| .|..||..|| .  .. ....||||||.| ||| .|..||.|||... .. ||.|.|.. | .|||.|...| |. ||..||| . . .|. 
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GNFVIKSI-SEV-ARTSFIERHFELTDQTSGQ-TVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAH-DPRTPLVIHCSAGVGRTGTYIAIDRLCNAAE
|.. ..   .|  . .... |..||..... . .  |.|..|  |||||||.....||.. ... . . . ..|.|.|||||||||||..|.| |.. .|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

DMHPmLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALL
. .  .   ..| |.||.|. .||.| || |.| |.|
aeee.vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 83-314 4.3e-70 231.2 In-house 1-234 (235) alignment 
Range on Protein: 83-314
Range on HMM: 1-234/235.0
NVTQNRYINIVAYDHSRVTVkpSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWP-DPNSELRV
| ..||| .|..||..|| .  .. ....||||||.| ||| .|..||.|||... .. ||.|.|.. | .|||.|...| |. ||..||| . . .|. 
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GNFVIKSI-SEV-ARTSFIERHFELTDQTSGQ-TVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAH-DPRTPLVIHCSAGVGRTGTYIAIDRLCNAAE
|.. ..   .|  . .... |..||..... . .  |.|..|  |||||||.....||.. ... . . . ..|.|.|||||||||||..|.| |.. .|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

DMHPmLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALL
. .  .   ..| |.||.|. .||.| || |.| |.|
aeee.vdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_PTPN23_pd Subfamily PTPN23 83-319 1.2e-51 170.3 In-house 43-282 (288) alignment 
Range on Protein: 83-319
Range on HMM: 43-282/288.0
NVTQNRYINIVAYDHSRVTVKpseaTKNNDYINANWVPGYK-GDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPNSELR-
....||. .|. |||.||...     ...||||| .| .   |   .|| |.| . . . ||.|..|| . .|||.... | || |..||||  . |   
yseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvk

VGNFVIKSISEVARTSFIERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHD-----PRTPLVIHCSAGVGRTGTYIAIDRLCNA
 |.. .   |.     ..||...|. . . ..  |. .|.  ||..|||..  .||.| ||.  |..      .||||.||||||||||..  .    ..
fgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavre

AEDMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAIDR
 |  . .|   .||  .|. | | ||.  |. |.| | | |. |
lekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 83-320 1.5e-46 153.7 In-house 48-282 (439) alignment 
Range on Protein: 83-320
Range on HMM: 48-282/439.0
NVTQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKlkchrYWPDpNSELRVG
. |.||| ...|.||.|||..         |||||.. ||  || |||.|||  ..   ||....|. .  |||.|| ||. |     |||  ..|   |
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywps.daevcyg

NFVIKSISEVARTSFIERHFELTDQ--TSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDPR--TPLVIHCSAGVGRTGTYIAIDRLCNAAeD
. ...   ..    .. | | . ..  |. .   | |..|| |||. ||  .  .|.|   |  | | .   |.|.||||||||||| ||.|   .    
diavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeql.k

MHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAIDRG
.   .  . .|  .|| |. .||.|.|| |.| |.|. |  |
lenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyG
0041856 (Phosphotyrosine protein) phosphatases II 83-317 2.5e-46 152.9 In-house 1-171 (182) alignment 
Range on Protein: 83-317
Range on HMM: 1-171/182.0
NVTQNRYINIVAYDHSRvtvkpseatkNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITneveagklkCHRYWPdpnselrvg
|.. ||| .|. |||||          ..||||||.. |.  .. .||.||| .. .|.|..|..|. ...||..|         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

nfviksisevartsfierhfeltdqtSGQTVPVQQMQYILWPDHGVPNtTRDLLNFRDEIYRahdPRTPLVIHCSAGVGRTGTYIAIDRLCNAaedmhpM
                          .  .  . | .|. |||||||. ...||.| .|...   .  | ..|||||||||||..|.. ..         
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevle...eggpvlVHCsaGvgRtgtlvaaylmkkl......g

LHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAI
. ....|...|. |.  |.|. || |..||||. .
vsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 83-315 2e-38 126.8 In-house 55-287 (305) alignment 
Range on Protein: 83-315
Range on HMM: 55-287/305.0
NVTQNRYINIVAYDHSRVTVKPSEatkNNDYINANWVPG-YKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPNSELRV
..|.||| .. . |.| | ..        ||| ||.|      .| .|..|||. ..   || |. .. |  |||. . || ||||| .|||  . | . 
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

--GNFVIKSISevaRTSFIERHFEL------TDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIyraHDPRTPLVIHCSAGVGRTGTYIAIDRLC
  .  |.. .|    .  .||  |.         . .|.. |...|.  ||| |||      |..   |      . |.|.|||||.||||| .||. . 
lksgivvenvs...gskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai...rgskvpivvhcsagigrtgtivaieyil

NAAEDMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLD
.   . .|     ..|  .|  | | .|. ||| |..  .|.
ekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 83-316 4.5e-33 109.4 In-house 35-269 (285) alignment 
Range on Protein: 83-316
Range on HMM: 35-269/285.0
NVTQNRYINIVAYDHSRVTVKpseaTKNNDYINANWV--PGyKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPNSEL-
|   ||| .. . . .|| .|     .. ||| |.|.  || | . .||. |||.|.... ||.||... .  ..|.   .| |  ||  |.|.   |. 
npdlnryadvrcieetrvvlk....nhdrdyihaswmrmpg.kdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

RVGNFVIK--SISEVARTSFIE--RHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDPRTPLVIHCSAGVGRTGTYIAIDRLCNA
..|.. |      | | .  |        |...| . . ....|   |||.  |. .| ....   . .     .|...||||||||| |.. ||     
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatir

AEDmHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDA
  .  | .   |.| |||  |   ||. .|. |.|. |.. 
ime.npniemldivremramrfqavqshmqflflyvvlmey
subfamily_CG42327_pd Subfamily CG42327 85-236 3.8e-20 66.8 In-house 30-184 (319) alignment 
Range on Protein: 85-236
Range on HMM: 30-184/319.0
TQNRYINIVAYDHSRVTVKPSEATKNNDYINANWVPGYKG-DKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPNS---ELR
 ..|.||.|   ..||...     ... |..|..| ||.  .  |||.| .  |. ..||...|||    || .|.  | |  .| .|.|  ..   .  
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

VGNFVIKSISEVARTSFIERHFELTDQTSGQTVPVQQMQYiLWPDHGVPNTTRDLL
 |.. .      ..  ..   . |      .. ..    |  |.. .||   . |.
yGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaali
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 94-176 9.4e-07 23.2 In-house 4-73 (130) alignment 
Range on Protein: 94-176
Range on HMM: 4-73/130.0
AYDHSRVTvkpseatkNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNeVEAGklkcHRYWPDPN
 .. ||.         .|.||||..|      . |.  | |. |.   ||.|. |. | ..|..   ||        |||| .
efevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.veee....deywpdse
0044763 (Phosphotyrosine protein) phosphatases II 95-311 1.7e-34 114.4 In-house 2-165 (178) alignment 
Range on Protein: 95-311
Range on HMM: 2-165/178.0
YDHSRVTVKPSEATKNNDYINANWVPGYkgdkAYIACQGPvpdafAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPNSelrvgnfviksisevar
.|..|| . . | .   |||||... ..     |.....|     |.......|. ...||..|.|.| |.|||..|||. ..                 
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

tsfierhfeltdqtsgqtvpvQQMQYILWPDHGVPNTTRDLLNFRDEIYRAH-DPRTPLVIHCSAGVGRTGTYIAIDRLCNAaedmhPMlHPRDVVAEMR
                      |...| .||||||. .. .|.| . | .|. ..  | ..||||||||.|| .|.. ..        .  . ......|
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....gl.sleeaielvr

KSRNfLVQTLVQYGFVYL
. |.  |..  |. ..|.
erRp.ivpnpgqlrqLye
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 96-314 1.4e-17 58.7 In-house 31-256 (290) alignment 
Range on Protein: 96-314
Range on HMM: 31-256/290.0
DHSRVTVKPSEATKNNDYINANWVPgYKGDKAYIACQGPVPDA-------FAAFWQMIWEQAVGLIVMITNEVEAGKL----KCHRYWPDPNS-ELRVGN
 ..||  |      |.||| || |  .  . . |. | |  .           || |. .  |  .||. .  |  .      | .| |.    ||....
eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg

FVIKSISEVARTSFIERHFELTDQtSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYrahDPRTPLVIHCSAGVGRTGTYIAIDRLCNAAEDMHPML
. .|  | ..   ...|. ... .  ..   |.  ..  | .  |...|. ||.  . .      .|| ..||  |. |  .  ||.  .    ...  .
ltvkCkskekeddvetRelvvkfd.deeeftvtHsllkgWnklnvqedtktllsliqkvk...asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsv

HPRDVVAEMRKSRNFLVQTLVQYGFVYLALL
. .||. ..|| |. ....  ...||  ...
kledvlkalrkqralaitsalelafvdagiv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 101-317 1.8e-17 58.3 In-house 24-221 (255) alignment 
Range on Protein: 101-317
Range on HMM: 24-221/255.0
TVKPSEAT-KNNDYINanwvpgykgdkayiacqgpvpdAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPN-SELRVGNFVIKSISevARTSFI
 |||.  . . | |.                       . ..|.|.|  .    .||...  |.|. ||..|.|      |.. .  . .    . .  .
hvkPekdkkrknlysl......................tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvv

ERHFELTDQTS--GQTVPVQQMQYILWPDHGVPNTTRDLLNfrdeIYRAHDPRTPLVIHCSAGVGRTGTYIAIDRLCN-----AAEDMHPMLHPRDVVAE
 |  |.| . .   .|  |.  .|  |...  |. .|..||    |...     ..|.|||.|.||. ... .. .         .     |  . .. |
lrtleitstlgekkkthtvkhysykGWieknaPelareiln....ilkvvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylsllee

MRKSRNFLVQTLVQYGFVYLALLDAI
.|..|.  ..| .|  |  | .|| .
lrskrkraihtPlqlafsilmvldlv
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 105-175 2.5e-07 24.6 In-house 116-181 (244) alignment 
Range on Protein: 105-175
Range on HMM: 116-181/244.0
SEATKNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNeVEAGklkcHRYWPDP
|...  | |||| .|        ||  | |. |.   ||.|. |. | ..|..   ||        |||| 
skgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs.veee....deywpds
0043147 (Phosphotyrosine protein) phosphatases II 109-310 5.6e-41 135.5 In-house 3-154 (172) alignment 
Range on Protein: 109-310
Range on HMM: 3-154/172.0
KNNDYINANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEveagklkchrywpdpnselrvgnfviksisevartsfierhfelTDQT
...|||||.....|   . .||.||| .  .| ||.|..|. ...||..|..                                            .  .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp

SGQTVPVQQMQYILWPDHGVPnTTRDLLNFRDEIYR--AHDPRTPLVIHCSAGVGRTGTYIAIDRLCnaaEDMhpmlHPRDVVAEMRKSRNFLVQTLVQY
.. .  . | .|. ||||||| ... ||.| . |..  | .|  | ..||||||||||| .|.. ..   ...     . ..||..|. |.  ||.  ||
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml...lgl....sleeavalvrekRpgavqnpsqy

GFVY
 |.|
rfly
0046846 (Phosphotyrosine protein) phosphatases II 109-313 2.4e-40 133.5 In-house 10-169 (176) alignment 
Range on Protein: 109-313
Range on HMM: 10-169/176.0
KNNDYINANWVPGYKgdkaYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDpnsELRVGNfviksisevartsfierhfeltdqt
 . ||||||.. |..    .||.|||.|. .|.|..|..|. ....|..|.||| |.|||..|||.   . ..|                          
ldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi.........................

sgqtvpvqQMQYILWPDHGVPNTtRDLLNFRDEIYRAHDPRTPLVIHCSAGVGRTGTYIAIDRLCNaaedmHPMLHPRDVVAEMRKSRN-FLVQTLVQYG
        | ... |||||||.  ..||.. ..|..| .   | ..|||||.|||||..|.. |.      .  | . ...|..|. |  . |||  || 
........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllel.....ekglsveealalvreqRplgavqtpeQyr

FVYLAL
|.| ..
flyefe
0051429 (Phosphotyrosine protein) phosphatases II 111-321 2e-46 154.1 In-house 4-229 (272) alignment 
Range on Protein: 111-321
Range on HMM: 4-229/272.0
NDYINANWVPGYKG---DKAYIACQGPVPDAFAAFWQMiWEQAVGLIVMITNEVEAGKLKCHRYWP-----------DPNSELRVGNFVIKSISEVARTS
..||||..|.|| .   ........|| |   | ||.. .|. .  ||....|.| |.|||.||||           |   . ..|..... .||.  . 
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

FIERHFELTDQ-TSGQTVPVQQMQYILWPDHGVPNTTrdLLNFRDEIYRahdpRTPLVIHCSAGVGRTGTYIAIDRLCnAAEDMHPMLH--------PRD
.| |...|| . . |..  | ...|. |||||||  .  ||.. ... .      |...|||||..||||..|...|  .  ... ...        ...
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlylee

VVAEMRKSRNFLVQTLVQYGFVYLALLDAIDRGL
.|.|.|. |   |||  || |.| |||..... |
aveelraqrpgavqteeqylflyeallellrsll
0036282 (Phosphotyrosine protein) phosphatases II 111-310 7.3e-42 138.3 In-house 2-163 (174) alignment 
Range on Protein: 111-310
Range on HMM: 2-163/174.0
NDYINANWVPGYKGDKAYIACQGPVPdafaaFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDpnselrvgnfviksisevartsfierhfeltdQTSG
.|||||... ..   . .||.||| .     ||.|..|. .  .|| ..|.| |. ||..|||.                                  . 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

QTVPVQQMQYILWPDHGVPNTTRdLLNFRDEIYRAHDP--RTPLVIHCSAGVGRTGTYIAIDRLCNAAEdmHPMLHPRDVVAEMRKSRNFLVQTLVQYGF
 .  . | .|. |||||||...  ||.| .....|.      |...||||||||||| .|.....   .  ... .  |.|.|.|. |   |||  || |
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtpsQyrf

VY
.|
ly
0051082 (Phosphotyrosine protein) phosphatases II 111-313 1.8e-32 107.4 In-house 3-149 (151) alignment 
Range on Protein: 111-313
Range on HMM: 3-149/151.0
NDYINANWVPGYkgdkaYIACQGPVPdafaAFWQMIWEQAVGLIVMITNEVEAGklKCHRYWPDPNselrvgnfviksisevartsfierhfeltdqtsg
.||||...| |.     .....|| .    .|.....|. .  ||....|.| |  .|..|.|. .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

qtVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRahDPRTPLVIHCSAGVGRTGTYIAIDRLCNAaedmhpmLHPRDVVAEMRKSRNFLVQTLVQYGFVY
  . | ..... |||.|.| ..  .|.| ... .  ..  |...|||||.||||| .|.....         . . ....|.|..|  .||.  |. |..
..ievlhipildwpdpglplsfdavleflellld..kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqflfql

LAL
.||
fal
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 114-311 2.6e-32 106.8 In-house 78-275 (301) alignment 
Range on Protein: 114-311
Range on HMM: 78-275/301.0
INANWVPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWP-DPNSELRVGNFVIKSI--SEVARTSFIERHFELTDQTSG
| |||.|     . .|| |||....   || |.    |  |||....||  . ||. | | .....|..| | ||      . . . ..|..|..| |  
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

-QTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAhdpRTPLVIHCSAGVGRTGTYIAIDRLCNAAEDmHPMLHPRDVVAEMRKSRNFLVQTLVQYGFV
 .|  |   ||  |.|.|||..  .| .. . . ..   . |.|.|||||.||. ..|. . | .. |  .| .   . ....|. |   |||  |  ..
fatrtvthyqysewtdrgvPkshaelfdlmelvkks...ekPivvhcsaGiGrsvafigteylarevea.dptieltealkhlrehrwngvqtnsqlywm

YL
 |
tl
0049260 (Phosphotyrosine protein) phosphatases II 119-310 1.9e-37 123.6 In-house 2-143 (152) alignment 
Range on Protein: 119-310
Range on HMM: 2-143/152.0
VPGYKGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWpdpnselrvgnfviksisevartsfierhfeltdqtsgqtvpvqQM
..||.  ...||.||| |  .| ||.|..|. .. |||.|...| |||||..|.                                            | 
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qy

QYILWPDHGVPNTTRDLLNFRDEIYR-AHDPRTPLVIHCSAGVGRTGTYIAIDRLCnaaedmhPMLHPRDVVAEMRKSRNFLVQTLVQYGFVY
... |||||||. .  || . . | . |.|.  | ..|||||||||||..|.. ..         . . ..|| .|. |.  |..  |. |.|
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 123-310 9.7e-19 62.3 In-house 2-197 (199) alignment 
Range on Protein: 123-310
Range on HMM: 2-197/199.0
KGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPNSEL-RVGNFVIKSISEVARTSFIERHFELTDQTS--GQTVPVQQMQ
||.. |||.| |. ...| ||||.||   | |||. ..    .     |||  .|   . |.. . . . ...  .    . ||..|.    |  . . |
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

YILWPDHGVPNTTR--DLLNFRDEIYRAH--DPRTPLVIHCSAGVGRTGTYIAIDRLCNAAEDMH-PMLHPRDVVAEMRKSRNFLVQTLVQYGFVY
.  | ..  || .    ..    |. . .  .  .|...||| | | || ..|.|    . |. .  ..   .|   .|..|  .. .| .| |.|
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 123-310 1.9e-18 61.4 In-house 1-196 (198) alignment 
Range on Protein: 123-310
Range on HMM: 1-196/198.0
KGDKAYIACQGPVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPNSEL-RVGNFVIKSISEVARTSFIERHFELTDQTS--GQTVPVQQMQ
||.. |||.| |. ...| ||||.||   | |||. ..    .     |||  .|   . |.. . . . ...  .    . ||..|.    |  . . |
kgqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

YILWPDHGVPNTTR--DLLNFRDEIYRAH--DPRTPLVIHCSAGVGRTGTYIAIDRLCNAAEDMH-PMLHPRDVVAEMRKSRNFLVQTLVQYGFVY
.  | ..  || .    ..    |. . .  .  .|...||| | | || ..|.|    . |. .  ..   .|   .|..|  .. .| .| |.|
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 134-313 2.1e-17 57.5 In-house 99-284 (302) alignment 
Range on Protein: 134-313
Range on HMM: 99-284/302.0
PVPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDP-NSELRVGNFVIKSISE-VARTSF------IERHFELTDQT--SGQTVPVQQMQYILW
|  ..   .| .| .  |...| ... || .. ||  |. |  . ||. |.. .|..|       |           |....   . .  .|. ...  |
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHGVPNTTRDLLNFrdeIYRAHDPRTPLVIHCSAGVGRTGTYIAIDR---LCNAaEDMHPMLhprDVVAEMRKSRNFLVQTLVQYGFVYLAL
|||| |. .   |.    .      .. ...||||||||||| .||     ||   ...  .|   ..|  .|. |   ||.  |  .. | .
pdhGapkeaytaldi...lkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcsk.kkvtdll...sivlpvrqcryGavqdeqqliylllcv
subfamily_hpo-7_pd Subfamily hpo-7 135-317 1.9e-14 48.2 In-house 43-227 (263) alignment 
Range on Protein: 135-317
Range on HMM: 43-227/263.0
VPDAFAAFWQMIWEQAVGLIVMITNEVEAGKLKCHRYWPDPNSE-LRVGNFVIKSiSEVARtSFIERHFELTDQTS--GQTVPVQQMQYILWPDHGVPNT
. .. ..|.|.|  .    .||...  |.|. || .|.|    | ... |  . . ..|     . .  ||. . .   .|  |.. .| .|...  |. 
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvct.tkvqs.dvllktlellstlgeKkkthtvkhysykgWiekndpel

TRDLLNfrdeIYRAHDPRTPLVIHCSAGVGRTGTYIAIDRLCN-----AAEDMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAI
.|. ||    | ..     .||.|||.|.||.  .  .. .         .     |  . .. |.|.||.  ..| .|  |  | .|| .
areiln....ilkvarnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv
0048076 (Phosphotyrosine protein) phosphatases II 198-313 1.3e-22 75.4 In-house 30-139 (145) alignment 
Range on Protein: 198-313
Range on HMM: 30-139/145.0
IERHFELTDQTSGQTVPVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDPRTPLVIHCSAGVGRTGTYIAIDRLCNaaedmHPmLHPRDVVAEMRKSRN
| . . ||. ... .  . | .|. |||||||. ...||.| . | .|..   | ..|||||||||||..|.. .       .  . . ......|. | 
ittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lg.vsleealelvrsqrp

FLVQTLVQYGFVYLAL
. |..  |. |.|...
gavpnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 207-311 3.4e-22 74.1 In-house 48-139 (144) alignment 
Range on Protein: 207-311
Range on HMM: 48-139/144.0
QtsgqtvpVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDPRTPLVIHCSAGVGRTGTYIAIDRLCnaaedMHPmLHPRDVVAEMRKSRNFLVQTLVQY
.       . | ... |||||||. . .||.| . | .|...  | ..|||||||||||..|....      ..  | . ...|..|. | . |..  |.
e.......giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klg.lsleealalvrsrrpgavpnpgql

GFVYL
 |...
rfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 214-318 3.8e-14 46.9 In-house 90-195 (440) alignment 
Range on Protein: 214-318
Range on HMM: 90-195/440.0
PVQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHD--PRTPLVIHCSAGVGRTGTYIAIDRLCNAAEDMHpMLHPRDVVAEMRKSRNFLVQTLVQYGFVYL
 ..|..|  |||.|||. .  .|.. ...  ...     ||..|||||.||||  ||.| .   |.     .    ..  ||..|  .|||  || ||. 
tlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsd.qidifsfinsmrnnrpqmvqtpeqyafvhe

ALLDAID
|.|... 
avlegll
PTPc_DSPc_SM00012 215-314 3.2e-25 83.7 In-house 2-104 (105) alignment 
Range on Protein: 215-314
Range on HMM: 2-104/105.0
VQQMQYILWPDHGVPNTTRDLLNFRDEIYRAHDPR---TPLVIHCSAGVGRTGTYIAIDRLCNAAEDMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYL
|....|  |||||||... ..|.. ... . .  .   .|.|.|||||||||||..|.| |..  |. .  .   ..| |.||.|. .|||. || |.| 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALL
|||
all
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 215-314 2e-12 41.5 In-house 217-341 (350) alignment 
Range on Protein: 215-314
Range on HMM: 217-341/350.0
VQQMQYILWPDHGVPNTTRDLLNFR-----------DEIYRAHDPRTPLVIHCSAGVGRTGTYIAIDRLCNAAEDMHPMLH----------PRD----VV
| |.|. .|.| .. .  ...|.              | .   .  .|...|||||||||||....| | .  |..... .           ||    .|
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

AEMRKSRNFLVQTLVQYGFVYLALL
 |.|| |  .||.| |. |.| |||
nelrkqrismvqnldqfifiYeall
PTEN_1 218-268 1.8e-07 26.1 In-house 95-149 (196) alignment 
Range on Protein: 218-268
Range on HMM: 95-149/196.0
MQ--YILWPDHGVPNTTRDL--LNFRDEIYRAHDPRTPLVIHCSAGVGRTGTYIA
..   . ..|||.|.  . .  ..  .| .......   ..|| ||.||.|| .|
veylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
0038934 (Phosphotyrosine protein) phosphatases II 219-269 6.5e-08 27.9 In-house 83-135 (194) alignment 
Range on Protein: 219-269
Range on HMM: 83-135/194.0
QYILWPDHGVPNTTRDLLNFRDEIYR--AHDPRTPLVIHCSAGVGRTGTYIAI
  . .||.|.. ..  ||.| | ...  . ||    ..|| ||.||||| .| 
lklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 240-314 2.7e-08 27.5 In-house 256-341 (349) alignment 
Range on Protein: 240-314
Range on HMM: 256-341/349.0
DEIYRAHDPRTPLVIHCSAGVGRTGTYIAIDRLCN----AAEDMHPM---LHPRD----VVAEMRKSRNFLVQTLVQYGFVYLALL
 . |   |  ..|..||||| ||||... .| | .      ...  .      .|    .| |.|| |  .|| | |. ..| |||
arlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealL
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 241-316 1.3e-11 38.9 In-house 219-294 (297) alignment 
Range on Protein: 241-316
Range on HMM: 219-294/297.0
EIYRAHDPRT-PLVIHCSAGVGRTGTYIAIDRLCNAAEDmHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDA
| .||. ||  .|..||||||||.|  .  | . .     . . . . ..  .|. |  ||||| |. ..| | |  
eslraemprnayllvhcsaGvGrsGvvvlsdvilaklrk.kripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_CG42327_pd Subfamily CG42327 249-312 3.5e-11 37.3 In-house 247-310 (319) alignment 
Range on Protein: 249-312
Range on HMM: 247-310/319.0
RTPLVIHCSAGVGRTGTYIAIDRLCNAAEDMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLA
. |||.||| ||||||. || |   .  |. .  .   ..|  .|. |   |.|  || |.|  
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 252-319 2.4e-08 28.2 In-house 1-67 (69) alignment 
Range on Protein: 252-319
Range on HMM: 1-67/69.0
LVIHCSAGVGRTGTYIAIDrLCNAAEDMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAIDR
.|.|||.| |||||.|||  .  |      ..   . |  ||| |  .|   ..| |.. || .|.  
mvvhcssgtgrtgtfiaim.vemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealkl
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 253-319 8.4e-08 26.5 In-house 1-66 (69) alignment 
Range on Protein: 253-319
Range on HMM: 1-66/69.0
VIHCSAGVGRTGTYIAIDrLCNAAEDMHPMLHPRDVVAEMRKSRNFLVQTLVQYGFVYLALLDAIDR
|.|||.| |||||.|||  .  |      ..   . |  ||| |  .|    .| |.. || .|.  
vvhcssGtGrtGtfiaim.vemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealkl