Gene MbrePTP-sf2-3 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily MbrePTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP041_AA protein Get Run
MbreP041_AA_54-323 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 40-317 3.1e-58 192.3 In-house 14-279 (318) alignment 
Range on Protein: 40-317
Range on HMM: 14-279/318.0
MQERGTFHIApLDTARFKRISQNVQPHSAvpEAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSgSDREYICAMGPLPATLKNWWRMI
..| |. ..   .  |..| ...|  . .      ||. ||....|.. .|||.| .. ... | ||||||. |   ....|| | .||| |....|||.
lresGellls.eeyerlsrseetvtslks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmv

WQEKVTCILMATGLVEKGTKKCERYWAPKpgQKVKVADMFVRTLATSQGDGYVRTLLEIEHT-SGESRKVMHFWYNTWPDHGVPRTPdgkpdaSNLLYMI
|. . . |.| | ..|.| .|..|||  |  .  .  .. |    . . . ||   .....| . |||.|  . | .|||.|||  .      ..|| ..
WeqnsavivmltqeeergkakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg......aslldlv

RDSKRSEKELNQgGPVLTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAILY
|.... ... .. ||.. |||||||| |. ||.| . . .. ..  |.  .....|. | ..||  .|||. .   . .
rqvskaqqksga.gpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllea
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 53-311 2.6e-17 57.4 In-house 25-272 (303) alignment 
Range on Protein: 53-311
Range on HMM: 25-272/303.0
TARFKRISQNVQPHSAVPEAVRNKRFNRHMDVLPHPETRVQLPtignDpaSAYINANYVHGpsGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATG
.  |....  . |. .  . |.|   || .||.    ..|.|     |  |.|| |.|..    |..  | .  ||. |  ..|.|| ..|| |.|.   
vnefekvvsylppsvsknqfvknmdknrfvdvicldhskvkls....d..ssyihasylel..dsskkailtqlplshtaadfwqmiieqkvkcvllllt

LVEKGtKKCERYWAPKPGQKVKVADMFVRTLATSQ---GDGYVRTLLEIehTSGESRKVMHF-WYNTWPDHGVPRtpDGKPDASNLLYMIRDSKRsekEL
  |   |    .  |.  . .|  . ..|     .   |||.|  .| .  . |. .  .|   |..||   .|   || |   . .. ..   |     
dseyd.klggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsv..sngdyksflhvhhykawphnsips..dgspkfvkqiwqlqsvlr...ky

NQGGPVLTHCSAGVGRSGTIiALDYICRLLETNKHADLNLV--IEEIRRDRVALVQHPQQYELAH
 .. | .    .|.||.||. ||   . |   .. | |.||  .| .|  |.  ||   |. . .
sdstptvymslsgcgragtf.alfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvy
subfamily_PTPRD_pd Subfamily PTPRD 54-325 9.1e-68 224.2 In-house 27-288 (564) alignment 
Range on Protein: 54-325
Range on HMM: 27-288/564.0
ARFKRISQNVQPHSAVPEAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSgSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGL
 ..|.|... | .  . ..  ||. ||  ....  ..|| | .. .|. | ||||....|   ....|| . |||. |....|||.|......| | | |
eeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkl

VEKGTKKCERYWaPKPGqKVKVADMFVRTLATSQGDGYVRTLLEI-EHTSGESRKVMHFWYNTWPDHGVPRTPdgkpdaSNLLYMIRDSKRSEKelNQGG
.|||..||..|| |. | . .. .. |   .. .   |. . ... ...| |||.| .| .  ||||||| ..       .|| .||.......  .. |
eEkgkvkchkYW.Pekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesa......tslLdlirkvralne..pdag

PVLTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAILYAQYVQANL
|.. ||||||||.|| |..|.. . ....|  |.  .....|..| |.|| ..||   |     . .  . ..
PivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntev
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 54-312 3.7e-54 178.9 In-house 26-277 (305) alignment 
Range on Protein: 54-312
Range on HMM: 26-277/305.0
ARFKRISQNvQPHSAVPEAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSGSDrEYICAMGPLPATLKNWWRMIWQEKVTCILMATGL
|..| . .. .    | .   ||. ||. .. .... |..| .  ... | ||||.||.| .... .|| | |||. |....||.|..|||. |.| |.|
aqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkk.kyivaqgPlkntvadfWrliveekvstivmltkl

VEKGTKKCERYWAPKPGQKVKVADMFVRTLATSQGDGYVRTLLEIEH--TSGESRKVMHFWYNTWPDHGVPRTpdgkpdASNLLYMIRDSKRSEKeLNQG
|| | .||..||. . ..|..  .. |    ...  .|.   |.|    .. ||| |...   .|||||||..      |. || .|.. ... |  ..|
veggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqf......atsllslikrvqkdqk.kdkg

GPVLTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHA
 |.| ||||||||.|. ||.|     |.. .  |.  |. ..|. |. .||  .||   | 
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhd
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 54-312 4.2e-34 112.6 In-house 19-287 (301) alignment 
Range on Protein: 54-312
Range on HMM: 19-287/301.0
ARFKRISQNVQPHSAVPEAVRNKRFNRHMDVLPHPETRVQLPTIGN--DPASAYINANYVHGPSgSDREYICAMGPLPATLKNWWRMIWQEKVTCILMAT
...|..... . .. |    .||..||. .. .... |. | .  |       ||||.|..| | . ...| | ||.  ||...||.|||||.. |.| |
eqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgys.ekkkfiaaqgpmkktlvdfWrliwqekpvsivmvt

GLVEKGTKKCERYWAPKPGQKVKVAD-------------MFVRTLA----TSQGDGYVRTLLEIEHTSgESRKVMHFWYNTWPDHGVPRTPdgkpdaSNL
.| |.  .|||.||     .. ..               . .| |.     . ..||.   ......  .|..|. .    ||..|| | |         
nlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk.sswdvlqlqvtdWpqdGvvrep......rtv

LYMIRDSKRSEKELnQGGPVLTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHA
|  | |    ..    ||||. |||..|.|||. ....        .   |.  |.. .|| .   |.  .||   . 
Lqviddvihrqqki.gggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiyd
0040438 (Phosphotyrosine protein) phosphatases II 55-323 5.4e-73 241.3 In-house 23-281 (317) alignment 
Range on Protein: 55-323
Range on HMM: 23-281/317.0
RFKRISQNVQPHSAVPEAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSGSDReYICAMGPLPATLKNWWRMIWQEKVTCILMATGLV
 |... ..  ..  | | . || .||..|.|| . .||.|  .|.|. | ||||.||.||. ... .|.. |||| |. ..|||.|...||.|.| | |.
efedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgvtvivmLtele

EKGTKKCERYWAPkpGQKVKVADMFVRTLATSQGDGYVRTLLEIEH-TSGESRKVMHFWYNTWPDHGVPRtpdgkpDASNLLYMIRDSKRSEKelNQGGP
|.| .||..||    |..... |..|..| . . .|.. . ||.|.  ..|||.|.||.| .|||||||       . . || ...  ... .  ..|||
elgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvpp......spdllldfleavreale..dpggp

VLTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAILYAQYVQA
|| ||||||||.||.||.......||.... |.  ...|.|. |   || |.||.  .  .. | ...  
vlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrklt
0043336 (Phosphotyrosine protein) phosphatases II 55-312 9.3e-68 224.0 In-house 25-271 (278) alignment 
Range on Protein: 55-312
Range on HMM: 25-271/278.0
RFKRISQNVQPHSAVPEAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSGSDReYICAMGPLPATLKNWWRMIWQEKVTCILMATGLV
 |... ..  ..  . . . || .||..|.|| . .||.|  .|.|. | ||||.|| |.. ... .|.. |||| |....|||.|...||.|.| |.||
efeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgvttivmLtelv

EKGTKKCERYWApkpGQKVKVADMFVRTLATSQGDGYVRTLLEIEH-TSGESRKVMHFWYNTWPDHGVPRTPDGKPDASNLLYMIRDskrsekelNQGGP
|.| .|| .||    |. ... |..|..| . . |.|... ||...  .||||.|.|..|  ||||||| ...   |  . .  ...        ...||
elgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale........dsngp

VLTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHA
|| ||||||||.||.|||......||.... ||  ...|.|. |   || |.||.  . 
vlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflye
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 55-329 2.8e-56 185.9 In-house 28-294 (319) alignment 
Range on Protein: 55-329
Range on HMM: 28-294/319.0
RFKRISQNVQPHSAVPEAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSgSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLV
 || ... |. .    .  .||. ||. ..|.   |||.|... . . | ||||... |     ...| ...||  |....|||.|.|.. ...| |.||
efkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyq.erekfiatqaPlentiedfWrmvWeeessivvmltklv

EKGTKKCERYWAPKpgQKVKVADMFVRTLATSQGDGYVRTLLEIEHTSGES--RKVMHFWYNTWPDHGVPRtpdgkpDASNLLYMIRDSKRSEKElNQGG
||.  |...||  .  . ..   . |  .   . ..|.   |.... |.|   |.|.|| |. ||||.||.      .|  || .... ..| .. .| |
eklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPe......katslldllkrirksrek.tqsg

PVLTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAILYAQYVQANLDVDE
|.  |||||||| || |.|| .   .. .   |.  .. ..|  |  .||.|.||.. .   . ...  .....|..
PivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqd
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 55-313 1.1e-52 174.1 In-house 32-285 (298) alignment 
Range on Protein: 55-313
Range on HMM: 32-285/298.0
RFKRISQNVQ----PHSAVPEAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSGSDrEYICAMGPLPATLKNWWRMIWQEKVTCILMA
 |.|...  .     .. | .. .||. ||..|...   .|| | .. .|  | |||| ..|. .|..  .| . .||..|....|||...|....| | 
efqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVml

TGLVEKGTKKCERYWaPKPgQKVKVADMFVRTLATSQGDGYVRTLLEI-EHTSGESRKVMHFWYNTWPDHGVPRTpdgkpdASNLLYMIRDSKRSEKElN
| |.|... |...|| |.  .| .  .. |. |.. .   .. . |.. .... ..|.| .. . .|||.|||..      |. .| ..|. ..|... .
tnleeldktkyhkyw.Pde.gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpen......atsvldllrkvrasqqq.a

QGGPVLTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAG
   ||. .|||||||||| ||.| .   .....  |.  |.. .|..|...||  .||   .  
gnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyea
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 55-317 2.8e-42 139.6 In-house 25-282 (290) alignment 
Range on Protein: 55-317
Range on HMM: 25-282/290.0
RFKRISQNVQPHSAV-PEAVRNKRFNRHMDVLPHPETRVQLPTIGND--PASAYINANYVHGPSgSDREYICAMGPLPATLKNWWRMIWQEKVTCILMAT
.||.. .  ..|..    .  ||. ||  ..... . |. |  |...   .  |||| |..| .  ...|| . ||.. ||...|..|||||||.|.| |
qfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgyk.ekkqyiatqgpvsntlvdFWkliwqekvtiivmlt

GLVEKGTKKCERYWAPKpGQKVkVADMFVRTLATSQGDGYVRTLLEIEHTS--GESRKVMHFWYNTWPDHGVPRTPdgkpdASNLLYMIRDSKRSEKELN
  .|.|..||  ||. . ..|  .  . .. |  .. ..|... ||.....  |....|...   .|...|    |     .. || . .  |   |. |
niieegkvkCqqYWpds.dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnp.....qtillvieemyktqrkrgn

qgGPVLTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAILY
  .... |||..||||.. .|..      .|.   |.  |... |  .  .||  |||.. .   . |
..tsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 55-315 4.8e-35 115.8 In-house 14-263 (283) alignment 
Range on Protein: 55-315
Range on HMM: 14-263/283.0
RFKRISQNVQPhSAVPEAVRNKRFNRHMDVLPHPETRVQLPTIGNdpasAYINANYVH--GPSGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATG
..||.|   .. . .  | .|||.||. ...|    ||.| .  .     |||| ..        |..|| | .||  | ...|.|...||.|.|.| | 
vlkrlsvpdld.adiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltk

LVEKGTKKCERYWaPKPG-QKVKVADMFVRTLATSQgdGYVRTLLEIEHT-SGESR-KVMHFWYNTWpdhgvprTPDGKPDASNLLYMIRDSKrSEKELN
| |   .|| .|| || | ..     . .|   ||.   ... .| . .  | .|   . |. .. |       .  |.    | |  .   . | .  .
lqedlrikCsqyW.PkrGsedyGeftvtlrkettsn..sfiikelllrvnssakstlllahyqvidW.......leygeqaiinslvkfnkvi.slqtes

QGGPVLTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAI
. ||.. |||.|.||... ||.      . |.   |.  |.. .| .|. .||  .|| | |  ..
kkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 56-323 7.3e-122 400.6 In-house 1-269 (270) alignment 
Range on Protein: 56-323
Range on HMM: 1-269/270.0
FKRISQNVQPHSAVPEAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVE
||....... .|..|||.|.|..||..|.||.|.|||.|... .|.|.||||||||.| .|....||.||||||.|||..|||||.||||.|.|.|||.|
fkeldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleE

KGTKKCERYWAPKPGQKVKVADMFVRTLATS--QGDGYVRTLLEIEhTSGESRKVMHFWYNTWPDHGVPRTPDGKPDASNLLYMIRDSKRSEKELNQGGP
||.|||||||...|..|||..|.....||.|  . .||..| |..| ..||.|...||||||||||||||..|.. ....||.|.|. .||||||....|
kgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaeP

VLTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAILYAQYVQA
.|.||||||||.||.||||...||||..|..|.. .|||.|.||.||||||.|||..... ..||.....
llvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerrak
0036941 (Phosphotyrosine protein) phosphatases II 56-319 3.5e-71 235.3 In-house 15-278 (297) alignment 
Range on Protein: 56-319
Range on HMM: 15-278/297.0
FKRISQNVQPHS-----AVPEAVRNKRFNRHMDVLPHPETRVQLptigNDPASAYINANYVHGPsGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMA
...  . ..|.       | . ..|.  ||..|.||.. |||.|    .|. | ||||.|| |. . .|..|.. |||| |. ..|||.|...||.|.| 
llkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgy.dlkrkfIatqgPlpntvedFWrmvweqnvtvIvml

TGLVEKGTKKCERYWAPKPGQKVKVADMFVRTLATSQ--GDGYVRTLLEIEH-TSGESRKVMHFWYNTWPDHGVPRtpdgkpDASNLLYMIRDSKRSEKE
| |||.| .||..|| .. |. ... |..|..| ...   |.|... ||...  .||||.|.||.| .|||||||       ... || .|.  ..  |.
telvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe......spaslldfielvrkvlkl

LNQGGPVLTHCSAGVGRSGTIIALDYICRLLE---TNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAILYAQ
|..||||| |||||||||||.||.|.....||   ...  |.  .. ..|. |   || ..||.  .   . . .
lpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
0039614 (Phosphotyrosine protein) phosphatases II 56-317 1.7e-70 233.2 In-house 38-288 (297) alignment 
Range on Protein: 56-317
Range on HMM: 38-288/297.0
FKRISQNVQPhSAVPEAVRNKRFNRHMDVLPHPETRVQLPTIGN-DPASAYINANYVHGPSGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLV
|... ... .   . . . || .||..|.|| . .||.| .... |. | ||||.|| |..  .|..|.. |||| |....|||.|...||.|.| | ||
feellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklv

EKGTkKCERYWAPKPGqkvKVADMFVRTLATSQGDGYVRTLLEIEHtSGESRKVMHFWYNTWPDHGVPRTPDGKPDASNLLYMIRDSKrsekelNQGGPV
|.|  ||..|| .. |   .  |..|..| . . |||... ||... .||||.|.||.|  ||||||| ...   .. .|.  .. .       ..||||
elgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealael......pkggpv

LTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAILY
| ||||||||.||.||.......||.... |.  ...|.|. |   || |.||.  .  .. .
lVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
DSPc_SM00195 56-317 2.9e-65 215.6 In-house 6-261 (263) alignment 
Range on Protein: 56-317
Range on HMM: 6-261/263.0
FKRISQNVQPH-SAVPEAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPsGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLV
|... .. .|. .   |  .||. ||. ..||  .|||.|... ... | ||||||. |.  ....||.. |||| |.. .|||.|.|||..|.| |  .
fekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EKGTKKCERYWAPKPGQKVKVADMFVRTLATSQGD-GYVRTLLEIEHTS-GESRKVMHFWYNTWPDHGVPRTPDgkpDASNLLYMIRDSKRSEkelnqGG
|.| .||.|||  . |.| .. .. | .  . . .  .... ||....   |.||| ...|..||||||| ...   .  .|| ... ||...      |
engkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstk...svlellravkksksts.....sg

PVLTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAILY
|.. ||||||||.||....|.|.. ||..|  |.  ...|.|  |  .||  .||  ..  .. |
pivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 56-317 2.9e-65 215.6 In-house 6-261 (263) alignment 
Range on Protein: 56-317
Range on HMM: 6-261/263.0
FKRISQNVQPH-SAVPEAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPsGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLV
|... .. .|. .   |  .||. ||. ..||  .|||.|... ... | ||||||. |.  ....||.. |||| |.. .|||.|.|||..|.| |  .
fekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EKGTKKCERYWAPKPGQKVKVADMFVRTLATSQGD-GYVRTLLEIEHTS-GESRKVMHFWYNTWPDHGVPRTPDgkpDASNLLYMIRDSKRSEkelnqGG
|.| .||.|||  . |.| .. .. | .  . . .  .... ||....   |.||| ...|..||||||| ...   .  .|| ... ||...      |
engkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstk...svlellravkksksts.....sg

PVLTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAILY
|.. ||||||||.||....|.|.. ||..|  |.  ...|.|  |  .||  .||  ..  .. |
pivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 56-321 5.8e-61 201.0 In-house 11-271 (274) alignment 
Range on Protein: 56-321
Range on HMM: 11-271/274.0
FKRISQNVQPHSavPEAVRNKRFNRHMDVLPHPETRVQL-PTIGNDPASAYINANYVHGPSGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLV
|  .  |....   ..  .... ||. ..|| ...|| | .  ..|. | ||||||..|... .. |. . |||| |....||||.||.|. |.| | | 
flelPlnfdqee..ldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklk

EKGTKKCERYWAPKPGQ--KVKVADMFVRTLATSQGDGYVRTLLEIEHTSGeSRKVMHFWYNTWPDHGVPRtpdgkpDASNLLYMIRDSKRSEKELNQG-
|.  .||..|.  . .   . .  |. ...  . . ..|  . | .....  .|.|.|.||  |||| .|.      ||..|| .... ..|..| |.  
eaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPd......dantlldlvleveesreeenakl

GPVLTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAILYAQYV
.||. |||||.|| |  || .  .| |. ..  |.  .. ..| ||  .||  .|||| |   .||.. .
apvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 56-312 8.5e-61 200.5 In-house 21-270 (281) alignment 
Range on Protein: 56-312
Range on HMM: 21-270/281.0
FKRISQ-NVQPHSAVPEAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSGsDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLV
.. ... .|.  .   .|  |.  ||....  .  |||..    ..  . |||||.| | .| ..||| . ||.||.|...|.|.|..||. | | |  .
yeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykg.ekeyiatqgPvPaslvafWqmvweqkvsaivmvtrei

EKGTKKCERYWApKPGQKVKVADMFVRTLATSQGDGYVRTLLEIEHTSGESRKVMHFWYNTWPDHGVPRTPdgkpdaSNLLYMiRDSKRSEKELNQGGPV
|.|  || |||   . ...|..|. |...|...   |..  ...|..|||.|.| .. | .||||||| |.      ..||   |.  .. .| ..  |.
eagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPatt......kellef.rkevlkltekktkapl

LTHCSAGVGRSGTIIALDYICRLLET-NKHADLNLVIEEIRRDRVALVQHPQQYELAHA
. ||||||||.|| |||| ... .|. ....|.. |..|.|..|  .||   |||  . 
vihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvyk
subfamily_Ptp69D_pd Subfamily Ptp69D 56-329 1e-52 174.2 In-house 28-297 (307) alignment 
Range on Protein: 56-329
Range on HMM: 28-297/307.0
FKRIS-QNVQPHSAVPEAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSGsDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLV
....  ....  . | |   |.  ||. |. .. .|||.|..|  .  | ||||....|     ...|.| .|. ||....||||.. .|| | | . | 
yekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgyke.kkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlt

EKGTKKCERYWAPKpgQKVKVADMFVRTLATSQGDGYVRTLLEIEHTS------GESRKVMHFWYNTWPDHGVPRTPDGkpdASNLLYMIRDSKRSEkel
||  |||..||.    ..|.  |. |..  ... . |..  |.. ..        .||||. . |..|.|  ||... |     .|....|. .. .   
eknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevarg...llklieqvrelykln...

nqGGPVLTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAILYAQYVQANLDVDE
   .|.. ||||||||||...||| .   |......|.  .. ..|..|  |||  .||.  .   . | .| ... |||.
..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvdd
subfamily_CG42327_pd Subfamily CG42327 56-226 3.9e-33 109.5 In-house 11-181 (319) alignment 
Range on Protein: 56-226
Range on HMM: 11-181/319.0
FKRISQNVQPHSAVPEAVRNKrfNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVE
|. . | .    .|| . ..|  .| ..|.| ||||| |. ||.|. . |..|.|| |.  ..  ||.|  .|  .  ..||..|. .   |. .| | |
frdlPqliaradevPvtskdk..srvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlse

KGTKKCERYWAPKPGQKV--KVADMFVRTLATSQGDGYVRTLLEIEHTS-GESRKVMHFWYnTWPDHGVPRTPD
.| |.| .|. .| . .      |. |       .| |. . | . .    |||.. |.||  |.. .||  . 
lGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeea
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 59-312 2.1e-26 87.6 In-house 27-265 (288) alignment 
Range on Protein: 59-312
Range on HMM: 27-265/288.0
ISQNVQPHSAVPEAVRNKRFNRHMDVLPHPETRVQLPtignDPASAYINANYVHgpSGS-DREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKG
 | |  .  .. . . |   .|. ..     |||.|     | .  ||.|| |   |.  .|  |||  || .|... |.|. .. |  |.| . |.|||
dspneasidiidsfianptrdryenlprcditrvkls....ddpdfyiaanvvs..sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekG

TKKCERYWAPKPGQKVKVADMFVRTLATSQG-DGYV-RTLLEIEHTSGESRKVMHFWYNTWPDHGVPRTPdgkPDASNLLYMIrdskrseK---Elnqgg
 .| . |.  | |.|...  .   .    .. |  |  .|| |...  |.  | .  .. |.|.|||          .|| ..       |   .     
keksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPeny...lsplrllevl.......kslqk.....

PVLTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHA
|.. |.||||||.||.|    . . |  . .  .. .... | .|   .|  .||  .| 
PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhr
0046845 (Phosphotyrosine protein) phosphatases II 60-321 8.4e-74 243.8 In-house 10-277 (284) alignment 
Range on Protein: 60-321
Range on HMM: 10-277/284.0
SQNVQP---HSAVPEAVRNKRFNRHMDVLPHPETRVQLPTIGND-PASAYINANYVHGPS----GSDREYICAMGPLPATLKNWWRMIWQEKVTCILMAT
 ... .   .  |  .. |.  ||..|.||   .|| | ....| . | ||||.||.|..     . ...|.. |||| |....|||.|...|..| | |
lsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmlt

GLVEKGTKKCERYWAPKpGQKVKVADMFVRTLATSQGDGYVRTLLEIEHT--SGESRKVMHFWYNTWPDHGVPRTpdgkpdASNLLYMIRDSKRSEKELN
.|||.| .||..|| .. |....  |..|..| . . |.|... ||....  .||||.|.||.| .||||||| .      ...|| ..|. ... ..|.
elvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvpps......pedlleflrlvrellenlp

QGGPVLTHCSAGVGRSGTIIALDYICRLLETNK---HADLNLVIEEIRRDRVALVQHPQQYELAHAGAILYAQYV
.|||.. ||||||||.||.||||.....||...   . |.  ..  .|. |   || ..||.. .  .. |....
gggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 61-310 1.3e-51 170.3 In-house 30-268 (515) alignment 
Range on Protein: 61-310
Range on HMM: 30-268/515.0
QNVQPHSAVPEAVrNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPsGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKK
 |. | .   | . | . ||. ..||.  .||.|  | ..| | |.|| |...   .|. ||.. ||..|.....||...||.|| | | | | |    |
pniypqtvaqeei.nfkknryknilPydsvrvklevindnPhsdyfnasyipsf.dndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkik

CERYWAPKPGQKVKVADMFVRTLATSQGDGYVRTLLEIEHTSGeSRKVMHFWYNTWPDHGVPRTpdgkpdASNLLYMIRDSKRSEKELNqgGPVLTHCSA
| .||  |||. ||   . | .....   | ..  |.. . .  || |  | .. |||.|||.       .| || .|.. | .. ...   |.. ||||
cgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd.srtvtqfhfteWPdkGvpkh......tssllklikevkadhgqyt..hpliihcsa

GVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELA
|||| | .|..| .    .| .  |.  ... ||..|. |||  .|| . 
GvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafi
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 61-311 4.1e-48 159.0 In-house 32-277 (297) alignment 
Range on Protein: 61-311
Range on HMM: 32-277/297.0
QNVQPHS-AVPEAVRNKR----FNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSGsdrEYICAMGPLPATLKNWWRMIWQEKVTCILMATGLvE
 .  |..   |. | .|.     .|. ..||    ||.|  ...|| | |.|| .|.|      ..|.   | .||....|.|...|.|. |.| . . .
flclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlndd.n

KGTKKCERYWAPKPGQKvkVADMFVRTLATSQGDGYVRTLLEIEHTSGESRKVM-HFWYNTWPDHGVPRtpdgKPDASNLLYMIRDSKRSEKELNQGgPV
...||| |||. |  ..    |. | .|..|.  |...  ||... .  .|.|.  . .  |||. |.|    | .|| || .| . . . .. ..| |.
erdkkcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaver....kdsassllklisevrkdfsqnaeg.Pl

LTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAH
| ||.||||| | ....| .    . .|. |.  ... .|..|. |||  .||.. .
lvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvy
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 61-313 3.8e-23 76.7 In-house 29-271 (312) alignment 
Range on Protein: 61-313
Range on HMM: 29-271/312.0
QNVQPHSAVPEAVRNKRFNRHMDVLPHPETRVQLptIGNDpaSAYINANYVHGPSGSDReYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKK
 |. . | .   .. | .||. ..      |  |   |..    || ||.|.  .  .| ..|. |||  |  ..|..      |.|.. .|.|| |..|
gnivsdsectaflkfkdlnrypniqcwdrgrftl..agde..nfyihanfvkictkper.fvctqgplentcthfwqlalslgstsiillcgfvedgsek

CERYWAPKPGqKVKVADMFVRTLATS--------QGDGYVRTLLEIEHTSGESRKVMHFWYNTWPDHGVPRTPDgkpDASNLLYMIRDSKRsekelnqgg
| .| .   |  |.. |  | |   .        .     | |  . ...|.  |. |. . .|||||.| . |    |  ||  ..  |.         
cakyisdivg.fvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscd...talrllsavkkdkk.........

PVLTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAG
||..||||||||.||.. .. .   |   .. ..  .   .|.||   |.   ||  |   
pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrc
0051299 (Phosphotyrosine protein) phosphatases II 62-318 1.3e-72 240.0 In-house 36-286 (288) alignment 
Range on Protein: 62-318
Range on HMM: 36-286/288.0
NVQPHSAVPEAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSGSDReYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKC
.....  .   . |.  ||..|.||   .||.| ...... | ||||.|..|.  . . .|.. |||| |....|||.|...|..| | |.|||.| .||
lpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekc

ERYWAPkpGQKVKVADMFVRTLATSQGDGYVRTLLEIEH-----TSGESRKVMHFWYNTWPDHGVPRtpdgkpDASNLLYMIRDSK---RsekelNQGGP
..|| .  |..... |..|..| . . |.|. . ||...      .||||.|.||.| .|||||||       ... || ..|. .   .     ..|||
aqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd......spellldflrlvrkala.....sgggp

VLTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAILYA
|. ||||||||.||.||||.....||.... |.  ... .|. |  .|| |.||.. .  .. |.
vvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPN13_pd Subfamily PTPN13 62-310 1.1e-57 190.4 In-house 22-261 (273) alignment 
Range on Protein: 62-310
Range on HMM: 22-261/273.0
NVQPHSAVPEAV--RNKRFNRHMDVLPHPETRVQLPTIGNdpasaYINANYVHGPSGSDR-EYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGT
...|   . ..   .||. ||. .|||  ||||.|   |.     ||||.... | | |. ||| . |||| | |. |.|.|. |.. | | |  .||| 
elkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgk

KKCERYWAPKPGQKVKVAD-MFVRTLATSQGDGYVRTLLEI-EHTSGESRKVMHFWYNTWPDHGVPRTPDgkpdasNLLYMIRDSKRSEKelnQGGPVLT
 ||.|||  . ..|.|| . . |. | . . ||.|   |.. .  |||||.|.|. . .|||||||....      .|| ...  .| ..   . ||...
vkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaa......ellqfvaevrrlqt...dagPivv

HCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELA
|||||.|||||.|..| .  |.| .|. |.. .....|. | ..||  .|| . 
hcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifv
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 62-312 6.8e-40 132.0 In-house 27-271 (307) alignment 
Range on Protein: 62-312
Range on HMM: 27-271/307.0
NVQPHSAVPEAV-RNKRFNRHMDVLPHPETRVQLPTIGNdpASAYINANYVhGPSGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKK
. .|..   ||   |   ||. ||     .|. . . |   || || |||. | .   . .||| ||| .|  ..| |. |||| ...|   ..| .  |
kktpegvtveafsantdknryqdvkcqdkgrivvkfdgl..asdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakik

CERYWAPKPGQKV---------KVADMFVRTLATSQgDGYVRTLLEIEHTsGESRKVMHFWYNTWPDHGVPRTpdgKPDASNLLYMIRDSKrsekelNqg
||.||  . |||           ||.. ...||  . |    | |... . ..|| . |. .. |||.|||..   .  | |||  .|  .      |  
ceqywpleegqklvfgeapntisvanlgakklapde.dlinvttlkvdwa.qksrtiqhlqwenwpdrgvpqi...nltainlleavrydt......n..

gPVLTHCSAGVGRSGTIIALDYIC-RLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHA
 ||. ||||||||||||.|. ..  ....     |.. ..||.| .|   .|   ||   | 
.pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhr
0050432 (Phosphotyrosine protein) phosphatases II 63-321 1.1e-74 246.9 In-house 56-302 (308) alignment 
Range on Protein: 63-321
Range on HMM: 56-302/308.0
VQPHSAVPEAVRNKRFNRHMDVLPHPETRVQLptignDPASAYINANYVHGPS-GSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKC
. .   | . ..|| .||..|.||   .|| |     |. | ||||.||.|.| ...|..|.. |||| |....|||.|...|..| | | |||.| .||
plleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekc

ERYWAPKPG-QKVKVADMFVRTLATSQGDGYVRTLLEIEH-TSGESRKVMHFWYNTWPDHGVPrtpdgkPDASNLLYMIRDSKRSEkelnQGGPVLTHCS
..|| ...| . ... ...|..| . . |.|... ||...  .||||.|.||.| .|||||||      |... || ...  ..|     .|||.. |||
aqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvP......pspeilldflelvrksl....pggpivVHCs

AGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAILYAQYV
|||||.||.||||.....||.... |.  ..  .|. |   || |.||.. .  .. |....
aGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
subfamily_PTPRA_pd Subfamily PTPRA 63-328 5.1e-47 155.4 In-house 46-305 (330) alignment 
Range on Protein: 63-328
Range on HMM: 46-305/330.0
VQPHSAVPEAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSGSDrEYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCE
.|    . .   ||. || ...||.  .|| |...   . | |||| ...|    | ..| | ||.  |....|||||. | . |.| | | |.  .||.
iqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekd.kfiaaqGPkeetvedfwrmiweqksativmltelkerkeekca

RYWaPKPGQkVKVADMFVRTLATSQ-GDGYVRTLLEIE----HTSGESRKVMHFWYNTWPDHGVPRTPDGkpdasnLLYMIRDSKRSEKelNQGGPVLTH
.|| |. |  |   .. |    .    |  || .|  .        .|| |  | ...||| ||| .| |      .| ...  |. ..  ...||.  |
qyw.PdeGl.vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiG......mlkllkkvkklnq..qsagpivvh

CSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAILYAQYVQANLDVD
|||||||.|| |.|| .   .....  |.  .....|  |  .||  .|||. .     |  | ...||| 
csaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvs
subfamily_eak_pd Subfamily eak 63-282 2.3e-08 27.8 In-house 38-267 (332) alignment 
Range on Protein: 63-282
Range on HMM: 38-267/332.0
VQPHSAVPEAVRNKRFNRH-MDVLPHPETRVQLPTIGNDPaSAYINANYVHGpSGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKC
 |.  .. |. | .  ||  ....|.    |.| .   ..   ||||  .   |   |.|| .  .    .  .|.|. ..|  .|..    ||.. .| 
yqrllsisetarleavnrnvvkivpydrylvrltssqlnr.lGyinaslaef.sevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleks

ERYWAPKPGQKVKVADMFVRTLATSQGDGYVRTLLEIEhTSGESRKVMHFWYNTWPDHGVPRTPDG--------KPDASNLLYMIRDSKRSE-KELNQGG
..|.  |  ...|   . | .    . . .   |||..    |. .|.|. .  | .  .|.  |         .  . .|. |  .  .|  |      
dkyfpdktreelkfGildverkefvkrniletrllels.kGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtp

PV---LTHCSAGVGRSGTIIALDYICRLLETNK
|    .  .. |  |.|. . .| . ||.. .|
psfapiiqsarGsaraGvfvvidllirlidnkk
0047943 (Phosphotyrosine protein) phosphatases II 66-314 2.8e-69 228.9 In-house 29-268 (273) alignment 
Range on Protein: 66-314
Range on HMM: 29-268/273.0
HSAVPEAVRNKRFNRHMDVLPHPETRVQLptigNDPASAYINANYVHGPSGSDReYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYW
   | . ..|| .||..|.||   .|| |    .|. | ||||.|| |.  . . .|.. |||| |....|||.|...|..| | | |||.| .||..||
tysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYw

APKPGQ-KVKVADMFVRTLATSQGDGYVRTLLEIEH-TSGESRKVMHFWYNTWPDHGVPRtpdgkpDASNLLYMIRDSKRSEKELNQGGPVLTHCSAGVG
 .. |. .... ...|..| . . |.|. . ||...  .||||.|.||.| .|||||||       . . || .|.. ..  ..|...|||. |||||||
pleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvpp......slesllefielvrkalealpsngpvvVHCsaGvg

RSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGA
|.||.||||.....||...  |.  ..  .|. |   || |.||.. .  .
RtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeal
0045450 (Phosphotyrosine protein) phosphatases II 66-312 2.9e-68 226.2 In-house 46-298 (307) alignment 
Range on Protein: 66-312
Range on HMM: 46-298/307.0
HSAVPEAVRNKRFNRHMDVLPHPETRVQLPTIGND-PASAYINANYV--------HGPSGsDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEK
.  . . . || .||..|.|| . |||.| ..... . | ||||.||        .|.   .|..|.. |||| |....|||.|...||.|.| |.|||.
eysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvel

GTKKCERYWAPKpGQKVKVADMFVRTLATSQGDGYVRTLLEIEH--TSGESRKVMHFWYNTWPDHGVPRtpdgkpDASNLLYMIRDSKRSEKELNQGGPV
| .|| .||  . |...   ...|..| ... |||... ||...   .||||.|.||.| .|||||||       . . || .|.  ..  .||..||||
grekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp......sfeelldfieevrkaleelpkggpv

LTHCSAGVGRSGTIIALDYICRLLETNKH---ADLNLVIEEIRRDRVALVQHPQQYELAHA
| ||||||||.||.||.....|.||...     ||  .....|. |   || |.||.  . 
lVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflye
subfamily_PTPN1_pd Subfamily PTPN1 66-327 7.4e-52 170.8 In-house 23-280 (290) alignment 
Range on Protein: 66-327
Range on HMM: 23-280/290.0
HSAVPEAVRNKRFNRHMDVLPHPETRVQLPTIGNdpasAYINANYVHGPSgSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYW
. .. .  .|.  ||. || |.  .|..|    |     ||||. |. .   .|.|| . |||| | . .|.|.|..|  ...|   .|||.. || .||
ptreaklpenrnlnryrdvspydhsrikleradn....dyinaslvelee.akrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

APKPG-QKVKVA--DMFVRTLATSQGDGYVRTLLEIEH-TSGESRKVMHFWYNTWPDHGVPRTPDgkpDASNLLYMIRDSKRSEKelnQGGPVLTHCSAG
  .   .....    . |. ... . . |.. |||.|  .. |.|...|| | |||| |||..|       ..|. .|.|    .   . ||.. |||||
Pqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespa...aflkflfkvresGslss...dvGpavihcsaG

VGRSGTIIALDYICRLLETNKH---ADLNLVIEEIRRDRVALVQHPQQYELAHAGAILYAQYVQANLDV
.|||||.. .| .  |.| ...    |.. |. |.|. |. |.| ..| ....   .  |. .. .  |
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssv
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 66-314 2.6e-45 150.1 In-house 55-287 (319) alignment 
Range on Protein: 66-314
Range on HMM: 55-287/319.0
HSAVPeavRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSGSDrEYICAMGPLPATLKNWWRMIWQEKVTCILMATglvekgTKKCERYW
.. ..   .||  || ...|.. ...|.|  .     | |||| .| |    |  || | |||. ||...|||||. ... |.. |       .|| .||
fanld...qnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkd.kyiaaqGPldntladfWrmiweyncstivllt......kdkcsqyw

APKPGQKVKVADMFVRTLATSQGdgYVRTLLEIEH--TSGESRKVMHFWYNTWPDHGVPRTPdgkpdaSNLLYMIRDSKRSEKELNQGGPVLTHCSAGVG
  |  .| .  .. | ..  ..   ||   .|. .     . ||.  | .  |||.|||  |      |.|. ...  .  ..  |.  ... |||||||
plkivikeerfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdyp......sdlmrlvkkvrhltskenhranivvhcsaGvG

RSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGA
|.|. |.|| .   .. .|  |.  .....|..|  |||.  || . ..  
rtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_PTPN12_pd Subfamily PTPN12 67-327 7e-68 223.6 In-house 32-283 (290) alignment 
Range on Protein: 67-327
Range on HMM: 32-283/290.0
SAVPEAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSGsDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWA
... |. .|.. ||. |.||. ..||.| .| ... | |||||...|..| . ||| | ||||.||...|||||. .|. ..||  .|| | |||||||.
teagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgveg.kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

PKPGQKVKVADMFVRTLATSQGD-GYVRTLLEIEHTsGESRKVMHFWYNTWPDHGVPRTPDgkpdasNLLYMIRDSKRSEKelNQGGPVLTHCSAGVGRS
 . ......... | . .  . | ...   |..|.  .|||||  | |. |||||||....      .|| .|.. .. ..  ..  |.. |||||||| 
eegeeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvPssak......sllelielvrelqe..sedaPlvvhCsaGvGrt

GTIIALDYICRLLETNKH---ADLNLVIEEIRRDRVALVQHPQQYELAHAgAIlyAQYVQANLDV
|||||.||. .||...|     |.  .. |.|..|.||||  .|||| .  |.  |..||..|..
Gtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvyk.av..aelvqkelei
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 68-316 8e-34 111.7 In-house 38-233 (392) alignment 
Range on Protein: 68-316
Range on HMM: 38-233/392.0
AVPEAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPsGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGtkkcerywap
.| .   |.. ||. ..||. ..||.|  | . | | |.|| |...   ... ||.. || .|.|...|||..||.|| | | | | |            
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsf.dnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........

kpgqkvkvadmfvrtlatsqgdgyvrtlleiehTSGESRKVMHFWYNTWPDHGVPRtpdgkpDASNLLYMIRDSKRSEKELNqgGPVLTHCSAGVGRSGT
                                    . | |  | .  |||..||.       .|.|| .|.. |    .     |.. ||||||||.| 
.................................kgddartvaqfhftewPdkdvpk......htssllkfikevkadfGqyt..hpliihcsagvgrtgv

IIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHaGAIL
.|..| .    .. .  |.  .. .||| |  .||  .|| . . ||.|
visidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiy.gavl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 68-321 2.5e-30 100.4 In-house 26-262 (267) alignment 
Range on Protein: 68-321
Range on HMM: 26-262/267.0
AVPEAVRNKRFNRHMDVLPHPETRVQLPTIGNDpasaYINANYVHGPSgSDREYICAMGPLPATLKNWWRMIWQEKVTCILMatgLVEKGTKKCERYWAP
.   |  |. .||  |.||. .||| | |  ..    |||| ||.|     . .|   .||  |  ... .| ..||. | .   |   .| .  ..| |
sqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivl...ltkvftdnirlfwPP

KPGQKVKVADMFVRTLATSQGDGYVRTLLEIEHTSGESRKVMHFWYNTWPDHgVprtpDGKPDASNLLYMIRdSKRSEkelNQGGPVLTHCSAGVGRSGT
| ||  |  |. |      . . |    ||..     ...|  ..|. |    .    . ||    |. ..   .. |   | . |.. .||.|||||||
kmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnin.t....nnkpylkplfgila.knqle...ngnrPlvvacsdGvGrsGt

IIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAILYAQYV
 . .|   . . |.  .|.   . .||  |..||.  ..|   |     ||.. 
flvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaegr
subfamily_PTPRB_pd Subfamily PTPRB 69-313 5.7e-65 214.2 In-house 45-280 (293) alignment 
Range on Protein: 69-313
Range on HMM: 45-280/293.0
VPEAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSgSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWaPK
. |. .|.  ||. ..||. ..||.| .. ... | ||||||..| . | ||.| . |||| |... |||.|..|.. |.| | ||||| .|||.|| |.
aaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyn.sprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYW.Pa

PGQKVKVADMFVRTLATSQGDGYVRTLLEIEHtSGESRKVMHFWYNTWPDHGVPRTPDgkpdasNLLYMIRDSKRSEKELNQGGPVLTHCSAGVGRSGTI
  . |   |. |  .|... . .|   |.||. . |.|||... . .||||||| ...      .|| ..|  ... .. .. .|.. ||||||||.|| 
deepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPektk......tlldfvrtvreaiektaskrPivvhCsaGvGRtGtf

IALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAG
|||| . . .|..   |.  .. |.|..|. |||  .||   |  
ialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqc
subfamily_PTPRG_pd Subfamily PTPRG 69-312 7.5e-50 164.7 In-house 41-281 (563) alignment 
Range on Protein: 69-312
Range on HMM: 41-281/563.0
VPEAVRNKRFNRHMDVLPHPETRVQLPTIGN-DPASAYINANYVHGPSgSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWaP
  ..  ||| ||......  ..||.|  . . .    ||||||..|     ...| . |||. |.. .|||||...|. | | | |||.| .||..|| |
hsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYW.P

KpGQKVKVADMFVRTLATSQGDGYVRTLLEIEH-----TSG--ESRKVMHFWYNTWPDHGVPRTPdgkpdASNLLYMIRDskrSEKELNQGGPVLTHCSA
|  . ...  . |.  .. .   |    | |..     ..   . ..|... | .|||||||  .     . .| .....   |  . .. ||.. ||||
k.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehs.....lpvLifvkks...saankaeaGPivvHcsa

GVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHA
||||.|| |.|| . . .....  ..  ..  ||  |  |||   ||   | 
GvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhd
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 69-317 3.4e-49 162.3 In-house 3-241 (250) alignment 
Range on Protein: 69-317
Range on HMM: 3-241/250.0
VPEAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSGSdREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKkCERYWapk
| .  .||  ||..|...  ..|| | .   |  | |||| ..|| ... . .| . |||.||....|||...||.. |.| | |.|.. . ...||   
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqyw...

P-GQKVKVADMFVRTLATSQ-GDGYVRTLLEIEHTSGESRKVMHFWYNTWPDHGVPRTpdgkpdASNLLYMIRDSKRSEKELnQGGPVLTHCSAGVGRSG
|  .  |  |. |  | . . .|  .|.|   ...  ..| | .. . .||| |||..      |   | .... ..|...  . .||. .|||||||||
PvekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPev......atavLellkkvqasqqqa.gnaPvivqCsaGvgrsG

TIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAILY
. ||.| .   |...|  |.  ||. .|.||.  |.  .||   .  .. .
afiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_PTPRN_pd Subfamily PTPRN 69-312 1.7e-37 123.7 In-house 50-286 (297) alignment 
Range on Protein: 69-312
Range on HMM: 50-286/297.0
VPEAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWaPK
| .| .| . ||. .|||. ..||.| .  ..  | ||||  .         || . |||..|. ..|.|.|.. |. |.. | | |.|.|.|.||| |.
vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckryw.pd

PGQK-VKVADMFVRTLATSQGDGYVRTLLEIEHTSGESRKVMHFWYNTWPDHGVPRTPdgkpdaSNLLYMIRDSKRSEKElnQGGPVLTHCSAGVGRSGT
 |..  .. .. . .      |  ||..   .  . |.| |  | . .||..||| ..       .|| . |   .| .   .  |.. |||.|.||.|.
eGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasa......ksllefrrkvnksyrG..rscpivvhcsdGaGrtGv

IIALDYIC-RLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHA
 |..| .. |||   |. |.   .| .| .|  ||.  .|.|.| .
yilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 70-313 7.1e-57 187.6 In-house 42-274 (288) alignment 
Range on Protein: 70-313
Range on HMM: 42-274/288.0
PEAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGpSGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWaPKP
 .  .|.. ||. ..||. |.||.|    . . . ||||.|..| ......||.. |||..|....|......|.. |.| |.|||.| .|||.|| |. 
grlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidg.ekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYW.Pda

GQKVKVADMFVRTLATSQGDGYVRTLLEIEhTSGESRKVMHFWYNTWPDHGVPRTpdgKPDASNLLYMIRDSKRSEkelnqGGPVLTHCSAGVGRSGTII
.....  .. |  . . . . .|   |..|  ... ... .. | .|||||||.    | .  .||...  .. ..      ||.. ||||||||.|| |
dkpknyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhgvPes...kapllellrqvkvanqad.....tgpiivhCsaGvGrtgtFi

ALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAG
||| .   .|...  |.  .....|. |  |||  .|||  .  
aldalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyev
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 70-312 5.3e-49 161.8 In-house 44-273 (315) alignment 
Range on Protein: 70-312
Range on HMM: 44-273/315.0
PEAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSgSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPKp
   . ||. ||......  ..||||| . ||| | |.|||.. | .   | ||.| ||..|..|..||....|... |.| |.|||.  .|.|.||  | 
akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.

gqKVKVADMFVRTLATSQGDGY-VRTLleiEHTS-GESRKVMHFWYNTWPDHGVPRTpdgkpdASNLLYMIRDSKRSEKelNQGGPVLTHCSAGVGRSGT
  ||    . |      . . | ||||     ..  . |.|. . | .||| |||.       . .|. .||  |. ..  |. |... ||||||||.||
..kviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlhytswpdmgvpky......tiplmnlirtvkqhht..nsvgaivvhcsaGvGrtGt

IIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHA
 |.|| .   .|...  |.  .|. .|. |. .||  .||.. . 
fitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiyd
subfamily_PTPN23_pd Subfamily PTPN23 70-320 2.9e-43 142.7 In-house 38-282 (288) alignment 
Range on Protein: 70-320
Range on HMM: 38-282/288.0
PEAVRNKRFNRHMDVLPHPETRVQLPtignDPASAYINANYVHGPSGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPKP
  | ..   ||. |.||. ..||.|     .    |||| .|.. |    ..|.. .||. ||  .|.|....|.  | | .   |.| .|..|||  . 
aiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedk

GQKVKVADMFVRTLATSQGDGYVRTLLEIEHTSG-ESRKVMHFWYNTWPDHGVPRTPDgkpdasNLLYMIRDSKR--SEKELNQGGPVLTHCSAGVGRSG
|. ||  |. |    . . . .|.  |..|. .  . ..|.|  ...||..||| .|.      .|| ..   .   .... .   |.. ||||||||.|
getvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPe......tllqfldevesayeavqrksktPlvvhCsaGvgRtg

TIIAL-DYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAILYAQY
..  .   .  | . |  .|.  |.. .|..|   ||. .|.. .    . .|. 
vfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
0040439 (Phosphotyrosine protein) phosphatases II 71-312 2.1e-65 216.1 In-house 7-240 (249) alignment 
Range on Protein: 71-312
Range on HMM: 7-240/249.0
EAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSGSDReYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPkpG
. . ||  ||..|.|| . .||.|  ... . | ||||.|..|.  ..| .|.. |||| |....|||.|....|.|.|.| |||.| .||..|| .  |
llpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..g

QKVKVADMFVRTLATSQGDGYVRTLLEIEH-TSGESRKVMHFWYNTWPDHGVPRTPDGkpdasnLLYMIRDSKRSEKELNQGGPVLTHCSAGVGRSGTII
. ... |..|..| . . |.|... ||...   ||||.|.|..|  ||||||| ...       || .|.  .   .||..||||| ||||||||.||.|
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfed......lldfieavrkaleelpkggpvlVHCsaGvgRtGtfi

ALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHA
|.......||.... ||  .....|. |   || |.||.  . 
aaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflye
subfamily_PTPN14_pd Subfamily PTPN14 71-316 5.6e-50 165.0 In-house 45-294 (300) alignment 
Range on Protein: 71-316
Range on HMM: 45-294/300.0
EAVRNKRFNRHMDVLPHPETRVQLPTIGNDpASAYINANYVHGPSG-SDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPK-
.   |.. ||. ||||. ..||.| .  ..  . ||||  .. . | ..|.|| | |||. |....|.|.|...|. |.| |   |.| .|. .|.  . 
klpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkle

-PGQKVKVADMFVRTLATSQGDGYVRTLLEIEHT-SGESRKVMHFWYNTWPDHGVPRTPDGKPDASNLLYMIRDSKRSEKE-LNQGGPVLTHCSAGVGRS
   ..|.     | |  ... | .. | |...|  |.| |.|.|. |. |||||||. ..|  .  . .  .|    ||.|  ..  ||| ||||||||.
skkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrt

GTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAIL
| .|  | .   ||.|.. |.. |.. .|. |  |||   ||.  .   | 
GvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 71-311 7.2e-48 158.0 In-house 40-270 (315) alignment 
Range on Protein: 71-311
Range on HMM: 40-270/315.0
EAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSgSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPKPG
    | . ||. ..||  ..||.|  | ..| | |||| |...   .|. ||.. |||.|.....|||..||||| | | | . |    || .||  . .
retinfkknryknilPldsarvkleviddsPdsdyinasyiksvd.ddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrka

QKVKVADMFVRTLATSQGDGYVRTLLeIEHTSGESRKVMHFWYNTWPDHGVPRTPDgkpdasNLLYMIRDSKRSEKElnQGGPVLTHCSAGVGRSGTIIA
. |.   . | .| ...  . |   | .   | |||.|  | .. |||.||..          || .|.. | ....  .  ..| ||||||||.| .|.
dsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqts......sllklikevkadngk..kefsllvhcsaGvGrtGvvis

LDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAH
.| .   .. ..  |.  .....|..|. |||  ..| . .
idevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiy
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 71-312 1.5e-39 130.7 In-house 43-272 (287) alignment 
Range on Protein: 71-312
Range on HMM: 43-272/287.0
EAVRNKRFNRHMDVLPHPETRVQLPtignDPASAYINANYVHGPSgSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPKPG
 | .||  ||  ..|.. . || |     .    |||| .. | . .....| | .|.  |..|.|..|....|| |.| . . |. ...| .||. .  
iasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgyk.ekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks

qkVKVADMFVRTLATSQGDGYVRTLLEIEHTS--GESRKVMHFWYNTWPDHG-VPRtPdgkpdASNLLYMIRDSKRSEKELNqgGPVLTHCSAGVGRSGT
  | . .  .. |   . .||.   ||.....  |. ..|. . . .|...| |.. |     .. || . .  |   |. |  .... |||..||||..
..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvte.p.....qtillvieemyktqrkrgn..tsivvhCsdtvGrsam

IIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHA
 .| .   .  .|.   |.  |... |  .   ||  .||.    
fcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfind
subfamily_ptpA1_pd Subfamily ptpA1 71-271 1.8e-29 97.7 In-house 43-249 (418) alignment 
Range on Protein: 71-271
Range on HMM: 43-249/418.0
EAVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPsgSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPKPG
.  .|   ||. ..||   |||||  | .   | ||||||. |     ...||. |||| |. ..|||.|....  |.| .   |.   ||.|||  . |
dkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga..ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqig

Q-KVKV-------ADMFVRTLATSQGDGY-VRTLLEIEHT-SGESRKVMHFWYNTWPDHGVPrtpDGKPDASNLLYMIRDSKR-SEKELNQGGPVLTHCS
  .. .          .   |     |        .|  |  ||.| . .. |. |||| .|   |      .||. | . .       ..  |.. |||
geqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnip...dhtqpfrqllhsitnrqnqiipssdrnvpiivhcs

AGVGRSGTIIAL
|||||.||. . 
agvgrtgtfcta
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 71-181 1.1e-17 58.8 In-house 43-168 (350) alignment 
Range on Protein: 71-181
Range on HMM: 43-168/350.0
EAVRNKRFNRHMDVLPHPETRVQLPTI--------GNDPASAYINANYVHGP-----SGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKG
| |.    ||. ..||.  .||.|.              .. ||||||.. .       .|  || . .||| |.......| . ||. ||. | .|| .
eGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdveln

TKKCERYWAPKPGQ--KVKVADMFVR
 .||.|||     .  .||.|..   
lekcyrYWqegsydditvklaskwen
0042113 (Phosphotyrosine protein) phosphatases II 72-311 7.3e-64 210.8 In-house 6-236 (245) alignment 
Range on Protein: 72-311
Range on HMM: 6-236/245.0
AVRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSGSDReYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPkpGQ
 . || .|| .|.||.. |||.|. .|.|. | ||||.||.|.  ... .|.. |||| |....|||.|....|.|.| | ..|.| .||..|| .  |.
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ge

KVKVADMFVRTLATSQGDGYVRTLLEIEH-TSGESRKVMHFWYNTWPDHGVPRTPDGKPDASNLLYMIRDSkrsekelNQGGPVLTHCSAGVGRSGTIIA
.... |..|..| . . |.|... ||...  ..|||.|.|..|  ||||||| ...   |. ...  .. .       ...|||| ||||||||.||.||
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.......dsngpvlVHCsaGvgRtGtfia

LDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAH
.......||...  .|  ...|.|. |   || |.||.  .
aylmleqlekelgvsleeavkelrsqRpgavqtpsqyrfly
0045098 (Phosphotyrosine protein) phosphatases II 72-316 3.3e-61 202.4 In-house 30-270 (278) alignment 
Range on Protein: 72-316
Range on HMM: 30-270/278.0
AVRNKRFNRHMDVLPHPETRVQlptigndpasAYINANYVHGPsgsDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPkpGQ
 . |. .|| .|.|| . .||            ||||.|..|.   ....|.. |||| |. ..|||.|....|.|.|.|.|||.| .||..|| .  |.
ylgnldknRykdilpydhsrVk..........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..gg

KVKVADMFVRTLATSQGDGYVRTLLEIEH-----TSGESRKVMHFWYNTWPDHGVPRTP--DGKPDASNLLYMIRDSKRSEKEL-----NQGGPVLTHCS
 .   |..|..| ... | |. . |....     ...|||.| |..| .||||||| .|  .   .. . .   ..   | ...     ..||||| |||
sltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCs

AGVGRSGTIIALDYICRLLetNKHADLNLVIEEIRRDRVA-LVQHPQQYELAHAGAIL
|||||.||..|......||  ... ||  ...|.|. |    ||...||.  .  ...
aGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_PTPN6_pd Subfamily PTPN6 72-317 2.3e-56 186.0 In-house 51-296 (306) alignment 
Range on Protein: 72-317
Range on HMM: 51-296/306.0
AVRNKRFNRHMDVLPHPETRVQLPtIGNDPASAYINANYVH-GPSGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWaPKPG
 ..||. ||.  .||. .||| |    . | | ||||||..    |||..|| . | |..|....|||.|||. . |.|.|  ||.| .|| ||| |.  
kpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYW.Pdee

QKVKVADMFVRTLATSQGDGYVRTLLEIEH--TSGESRKVMHFWYNTWPDHGVPRTPdgkpdaSNLLYMIRDSKRSEKELN--QGGPVLTHCSAGVGRSG
.| .  .. |.... .. . |.   | ...  ...|.|.|... ...|||||||. |      . .| ...| .| ..||.  . ||.. |||||.|| |
ekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdp......gavLdfledvnrkqeeleeaeagpivvhCsaGiGRtG

TIIALDYICRLLETNK---HADLNLVIEEIRRDRVALVQHPQQYELAHAGAILY
|.| .| . .|.|...   . |.. ... .|. |  |||  ||| . .     |
tfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky
0049772 (Phosphotyrosine protein) phosphatases II 72-322 1.9e-34 115.2 In-house 43-284 (314) alignment 
Range on Protein: 72-322
Range on HMM: 43-284/314.0
AVRNKRFNRHMDVLPHPeTRVQLPTIGNDPaSAYINANYVHGPsgsdREYICAMGPLPATLKNW----------WRMI--WQEKVTCILM----------
 ..|.  ||..|.|| . .||.||. ...  |.||||.||.|.    . .|.. |||. |. .           |||.  .. .|  | |          
lflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladel

-----------ATGLVEKGtkkceRYWAPKPGQKVKvadmfvrtlatsqgdgyvrtlleiE---HTSGESRKVMHFWYNTWPDHGVPRTPDgkpdASNLL
            ..| ..|      .. ..  .  |                        |     .  .| ......  .||...| . |       .|
srLdaAlgKtpllildgng.....neptaadlellk........................eelydpelferlgikylripvpDgsaplled....fdefl

YMIRDSkrsekelNQGGPVLTHCSAGVGRSGTIIALDYICRLLetnkHADLNLVIEEIRRDRV-----ALVQHPQQYELAHAGAILYAQYVQ
 .|..        ..||||| ||.||.||.|| ....|...||    . .|. ..|..|. |       ... ..|||  .     | ....
efieea.......dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 72-310 1.3e-29 97.7 In-house 35-261 (281) alignment 
Range on Protein: 72-310
Range on HMM: 35-261/281.0
AVRNKRfNRHMDVLPHPETRVQLPT-IGNDPASAYINANYVHGPSgSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPKPG
 | ||. ||....     .||||   . |  .. || |||.. |    | || . ||   |  ..|||||||. |.|.|   ..|   .||  |.  .  
pvnnkk.nrylnipcldisrvqlkvkmpnknstdyihanyirspf.lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah

QKVKVADMFVRTLATSQGDGYVRTLLEIEHtSGESRKVMHFWYNTWPDHGVPrtpdgkpDASNLLYMIRDSKRSekelnQGGPVLTHCSAGVGRSGTIIA
  ...  . |    ..     | | |.. .  ||.| . |. .. |||  ||       ..|...  |    |.     .  | . |||||||||||..|
cclqfdklsvsyedstvnkslvttrlnlsy.egetrlithwlwkewpdwqvp.......essevmlkilrkira.....rstppvihcsagvgrsgtlma

LDYICRLLETN-KHADLNLVIEEIRR-DRVALVQHPQQYELA
..   . . .     |.. ..  .|   | | ||  ||| | 
veialqsihshftlpdikqivshlrvtgraasvqtlqqymli
subfamily_PTPN9_pd Subfamily PTPN9 73-322 1.8e-59 196.2 In-house 40-294 (297) alignment 
Range on Protein: 73-322
Range on HMM: 40-294/297.0
VRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSgSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPKPGQK
  | . ||. |||   ||||.|... .|.|| |||||.| |     . .| . |||. | ...|||.|...|  |.|.| .||.|  || .|| .. .. 
ranleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeess

VKVADMFVRTLATSQGDGYVRTLLEIEH-TSGESRKVMHFWYNTWPDHGVPRTPDgkpDASNLLYMIRDSK--------RSEKELNQGGPVLTHCSAGVG
 . .|. |... . . . |. . |||.. . .|||||.|| . .|||.|||..     .  ..| ..|. .         ..|   .| |.. |||||.|
aefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaa...slldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiG

RSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAILYAQYVQ
|.|| |.||.    ||.   .|.  ... .|  |   .| |.|||. .   . ||.. .
rtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalelk
0037934 (Phosphotyrosine protein) phosphatases II 73-311 9.3e-56 184.4 In-house 8-235 (243) alignment 
Range on Protein: 73-311
Range on HMM: 8-235/243.0
VRNKRFNRHMDVLPHPETRVQLptignDPaSAYINANYVHGPsgsDReYICAMGPLPATLKN----WWRMIWQEKVTCILMATGLVEKGTKKCERYWApk
. |.  ||..|.|| . .|| |     .. | |||||.. ..   .| .|.  |||| |...    .|||.|....|.|.| | |||.| .||..||   
penlsknrysdilpydhsrvkl.....eg.sdyinanliyvt...pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..

pGQKvKVADMFVRTLATSQGDGYVRTLLEIEH--TSGESRKVMHFWYNTWPDHGVPRTPDGKPDASNLLYMIRDSKRSEKELNQGGPVLTHCSAGVGRSG
 |..    |..|..| ....|.|. . |..|.  .....| |.|..|  ||||||| .|.   |  . .. . ..  |   |..||||| ||||||||.|
.gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

TIIALDYICRLLetnkHADLNLVIEEIRRDRVA-LVQHPQQYELAH
|.||......||    . ||  .....|. |    || |.||.  .
tliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrfly
subfamily_PTPRK_pd Subfamily PTPRK 73-316 1.4e-51 170.2 In-house 41-274 (314) alignment 
Range on Protein: 73-316
Range on HMM: 41-274/314.0
VRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSGSdREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWaPKPGQK
  |.. || .|.|..  .||.| || .|| | ||||... .   . ...| . |||. |.|..||....|. ..|.| | |||.|  || .|| |. ...
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrp.aafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyW.Pedtev

vkVADMFVRTLATSQGDGYVRTLLEIEH---TSGESRKVMHFWYNTWPDHGVPRTpdgkpdASNLLYMIRDSKRSEKElnQGGPVLTHCSAGVGRSGTII
    |. |  . |.    .|  .. .|.   .  | |.| .| . .||||.||        |  || ..|  | |..|  . |... ||||| ||.|| |
..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvs......atgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfi

ALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAgAIL
|.| .. ..|...  |.  .. ..|  .| .|.  .|| . .  .||
aidivldmieregvvdvfnavktlrsrkvnmveteeqykfiyd.vil
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 73-332 1.9e-43 143.9 In-house 46-300 (325) alignment 
Range on Protein: 73-332
Range on HMM: 46-300/325.0
VRNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSGSDrEYICAMGPLPATLKNWWRMI--WQekvTCILMATGLVEKGTKKCERYWAPKPG
  ||  ||  .|..  ..|| | | ..|| | ||||.|..   . |  .. |  ||.||... ||..  |.   . ... .  ...| ..|  ||  . |
penkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkd.vflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavywpkemg

QKVKVADMFVRTLATSQGDGYVRTLLEIEHTS-GESRKVMHFWYNTWPDHGVPRTPDGKPDASNLLYMIRDSKRSekELNQGGPVLTHCSAGVGRSGTII
. ..   . |.  .  .   ||   |..  .. ||.| |  | . .|.| ||.. |       .|.  . .  ..  . .  .|.| ||||||||.|. |
ksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservta..ntkastpilvhcsaGvGrtGvfi

ALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAIlyAQYVQANLDVDERAI
.|  .   . .. . |.  ... .|.|| ..|.   || | . . .    |. .| ||   ..
slysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealv..eaymsgntdvpvssf
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 73-315 1.1e-40 134.3 In-house 36-274 (287) alignment 
Range on Protein: 73-315
Range on HMM: 36-274/287.0
VRNKRFNRHMDVLPHPETRVQLPTIGNdPASAYINANYVHGPSgSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWaPKPGQK
. . . ||. ||||  .||| | . |.   |.||||||| .    | ..|.| ||..||....||........ ... |  ||.. .|| .|| |.. . 
laavkknryadvlPiddtrvllsaege.lGsdyinanyvasyt.ddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykyw.PerevP

VKVADMFVRTLATS--QGDGYVRTLLEIEHTSGESRKVMHFWYNTWPDHGVPRTPDGkpdASNLLYMIRDSKRSEKELNQGGPVLTHCSAGVGRSGTIIA
..|    |  |  .  . .  ||.|  |.  . |.| |  . . .|||.... |  |      .   ...    ... .. ||.. |...|.||||...|
mrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavg...lirfvldvkqhielardasevGPlvvhddvGiGrsGilla

LDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAI
.  . . ||   . |   |.  .|  | |||| . |. |     .
tlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 73-309 8.4e-29 95.4 In-house 33-261 (285) alignment 
Range on Protein: 73-309
Range on HMM: 33-261/285.0
VRNKRFNRHMDVLPHPETRVQLPTIGNDpasaYINANYVHGPSGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPKPGQK
  |  .||. ||    |||| |     |    || |.... |   .  || . |||| || ..|.||.|||.. .||   |.| | .||  |.  | |. 
eanpdlnryadvrcieetrvvlknhdrd....yihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

VKVADMFVrTLATSQGDGYVRT------LLEIEHTSGESRKVMHFWYNTWPDHGVPRtpDGKPdasnllyMIRDSKRSEKELNQGGPVLTHCSAGVGRSG
||.    . ||.  . .    |      ... | .| |   . |     |||.  |   | .|       ||   |  .|   .  |.  ||||||||. 
vkfgkyei.tlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlape..darp.......mielykwvkkvnpkekpicvhcsagvgrta

TIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYEL
|.. .||    .  |   ..  .. |.|  |.  ||   |. .
tfvgidyatirimenpniemldivremramrfqavqshmqflf
subfamily_PTPN3_pd Subfamily PTPN3 74-310 6.5e-50 164.6 In-house 40-267 (280) alignment 
Range on Protein: 74-310
Range on HMM: 40-267/280.0
RNKRFNRHMDVLPHPETRVQLPTIGNdpasAYINANYVHG--PS-GSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWaPKPG
.|   ||. |.||. .|||.|    .     |||||||    || |    || . |||. | ...|.|.|..|.. |.| | |||.| .|| .|| |...
enlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyW.Pete

QKVKVADMFVRTLATSQGDGYVRTLLEIEH-TSGESRKVMHFWYNTWPDHGVPRtpdgkpDASNLLYMIRDSKRSEkeLNQGGPVLTHCSAGVGRSGTII
.... ... |.   ...   ||   | ... .. |.||.... |  |||||||       |....| ...  ..      .  ||. |||||.||.| .|
deleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPd......dsadflefvervrklr..sgkeePvvvhCsaGigrtGvli

ALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELA
.|.    |.|...      .. ..|  | .||| ..||.. 
lletalalieaaepvypldivrtmrdqramlvqtasqykfv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 74-315 5.5e-45 149.0 In-house 24-252 (284) alignment 
Range on Protein: 74-315
Range on HMM: 24-252/284.0
RNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSGSDrEYICAMGPLPATLKNWWRMIWQEKVTCILMATglvekgTKKCERYWAPKPGQKV
.||  || ...|.. ...|.|  .     | |||| .. |    |  || . |||. ||...|||||. ... |.. |       .|| .||  |  .| 
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkd.kyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivike

KVADMFVRTLATSQGdgYVRTLLEIEH--TSGESRKVMHFWYNTWPDHGVPRTPdgkpdaSNLLYMIRDSKRSEKELNQGGPVLTHCSAGVGRSGTIIAL
.  .. | ..  |.   ||   .|. .     . ||.  | .  |||.|||  |      |.|. ...  .  ..  |.  ... ||||||||.|. |.|
erfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdyp......sdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivl

DYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAI
| .   .. .|  |.  .....|..|  |||.  || . ..  .
dvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 74-319 2.3e-36 120.1 In-house 47-288 (305) alignment 
Range on Protein: 74-319
Range on HMM: 47-288/305.0
RNKRFNRHMDVLPHPETRVQLptIGNDPaSAYINANYVHGPSGSDReYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPKPGQ--
...  ||. ||    . ||.|   |  |   || ||||  |. . | .||.  ||  |  ..| | .|.||  |.|   |.|||.|||  |.| | ..  
qeagknrykdvgcldnnrvkl..egpwp.heyihanyvstptnpkr.fictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvl

-------KVKVADMFVRTLA-TSQGDGY-VRTLLEIEHTSGESRKVMHFWYNTWPDHGVPRTpdgkpDASnLLYMIRDSKRSEkelnqgGPVLTHCSAGV
       |. |      ||  ... .    .| | || . ...||| |. .. ||| ||| .     | . .| .. ... |       ||.  |||||.
efeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaa.....dla.ilellekarpsk......gpivvhcsagi

GRSGTIIALDYIC-RLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAILYAQ
||.|... |.||. .||. ..  | . ..  || .|   .|  .|| . |   . | .
grtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_CG7180_pd Subfamily CG7180 74-308 7.7e-32 105.1 In-house 41-280 (296) alignment 
Range on Protein: 74-308
Range on HMM: 41-280/296.0
RNKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSgSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTkKCERYWAPKPgqKV
 |.  ||. .|.|   .|| |.... .  | |||| || .    ..|||   .|   |....||....|.. .. . |   .    ..  || .|   | 
enreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..ke

KVADMFVRTLATSQGDGYVRTLLEIEHT-----------SGESRKVMHFWYNTWPD-HGVPRTPDGkpdASNLLYMIRDSKRSEKELNQGGPVLTHCSAG
.  ..|| .. . |    .   . . ..           . | | |..| . .|.  . ||    .     .|. ..|  ..  .| .. |||. ..| |
qygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstna...lielrrrvrlwrekvdedpeegPvvvvssdG

VGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYE
..|||  .|.|    |.| ... |.   .  .||.|  ||.  ..| 
asRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 74-166 8.7e-16 52.3 In-house 51-141 (310) alignment 
Range on Protein: 74-166
Range on HMM: 51-141/310.0
RNKRFNRHMDVLPHPETRVQLpTIGNDPASAYINANYVHGPSgSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWA
..   ||. ||. . ..||.| .| .     || ||||.        .||. |||  |. ..||||.||.   ||.    .|.|  ||  || 
kymhknrysdvvcldtsrvkl.kidksryedyihanyvktny.lrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywp
Y_phosphatase Protein-tyrosine phosphatase 75-312 3.1e-63 208.7 Pfam-A 1-231 (235) alignment 
Range on Protein: 75-312
Range on HMM: 1-231/235.0
NKRFNRHMDVLPHPETRVQLptIGNDPASAYINANYVHGPSgSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPKPGQKVK
||. ||. |.||  .|||.|   |.. .| |||||||.| . .....|.. |||. |.. .|||.|||||..| | | |.||| .||..||  . .....
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

VADMFVRTL-ATS-QGDGYVRTLLEIEHTSGES--RKVMHFWYNTWPDHGVPRTpdgkpdASNLLYMIRDSKRSEkeLNQGGPVLTHCSAGVGRSGTIIA
  |..|..   .. . ..|. . ||.... .||  |.|....|..|||||||..      ...|| .||. ..|.   .. |||. ||||||||.||..|
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes......pkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfva

LDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHA
||.... ||.... |.  ...|.|. |  .||  .||.  ..
ldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyk
Y_phosphatase Protein-tyrosine phosphatase 75-312 3.1e-63 208.7 In-house 1-231 (235) alignment 
Range on Protein: 75-312
Range on HMM: 1-231/235.0
NKRFNRHMDVLPHPETRVQLptIGNDPASAYINANYVHGPSgSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPKPGQKVK
||. ||. |.||  .|||.|   |.. .| |||||||.| . .....|.. |||. |.. .|||.|||||..| | | |.||| .||..||  . .....
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

VADMFVRTL-ATS-QGDGYVRTLLEIEHTSGES--RKVMHFWYNTWPDHGVPRTpdgkpdASNLLYMIRDSKRSEkeLNQGGPVLTHCSAGVGRSGTIIA
  |..|..   .. . ..|. . ||.... .||  |.|....|..|||||||..      ...|| .||. ..|.   .. |||. ||||||||.||..|
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes......pkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfva

LDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHA
||.... ||.... |.  ...|.|. |  .||  .||.  ..
ldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyk
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 75-312 2.3e-39 130.0 In-house 7-234 (239) alignment 
Range on Protein: 75-312
Range on HMM: 7-234/239.0
NKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWapkPGQKVK
||  ||. ... .  .|| |  . ||| | ||||.|..   || . ||.. | . ..  ..|||.|||.   |.| |||.|   ||| .||   |    |
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqyw...pdstsk

VADMFVRTLAT-SQGDGYVRTLLEIEHTSGESRKVMHFWYNTWPDHGVPRTpdgkpdASNLLYMIRdsKRSEKELNQGGPVLTHCSAGVGRSGTIIALDY
 ... |    |    |  .||..  .    | | | .. .  |||.|||.       |. .| . |  | ..  |    | . ||||||||.|... .| 
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy......atavlglrr..kitkdslpgarpwvihcsagvgrtgaflvida

ICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHA
. |  . .|  |.   .. || ||  .||  .|| . | 
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 75-312 2.7e-39 129.7 In-house 8-235 (239) alignment 
Range on Protein: 75-312
Range on HMM: 8-235/239.0
NKRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWapkPGQKVK
||  ||. ... .  .|| |  . ||| | ||||.|..   || . ||.. | . ..  ..|||.|||.   |.| |||.|   ||| .||   |    |
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqyw...pdstsk

VADMFVRTLAT-SQGDGYVRTLLEIEHTSGESRKVMHFWYNTWPDHGVPRTpdgkpdASNLLYMIRdsKRSEKELNQGGPVLTHCSAGVGRSGTIIALDY
 ... |    |    |  .||..  .    | | | .. .  |||.|||.       |. .| . |  | ..  |    | . ||||||||.|... .| 
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy......atavlglrr..kitkdslpgarpwvihcsagvgrtgaflvida

ICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHA
. |  . .|  |.   .. || ||  .||  .|| . | 
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 75-312 1.6e-38 127.2 In-house 3-233 (237) alignment 
Range on Protein: 75-312
Range on HMM: 3-233/237.0
NKRFNRHMDVLPHPETRVQLPTIGNDpaSAYINANYVHGPSGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWaPKPGQKVK
||  ||. ..  .  .|| |   |..  | ||||.|..|  |. ..||.| ||| .. ...|.|.|||| . |.| |||.|.  .|| .|| |.  |   
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkyw.pstdqpaa

VADMFVRTLAT-SQGDGYVRTLLEIE-HTSGESRKVMHFWYNTWPDHGVPRTpdgkpdASNLLYMIRDSKRSEKELNQGGPVLTHCSAGVGRSGTIIALD
   . |         |  ||.||  . .|  | | .  . . .|||.|||.       .. || . ..     . ... || . ||||||||.| .. .|
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqq......taallrfrkniinrsphvsesgpwiihcsagvgrtgiflvid

YICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHA
 . |  . .|  |.   .  |  ||  ..|  .|| . | 
amlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihq
0041856 (Phosphotyrosine protein) phosphatases II 75-311 1.6e-38 127.5 In-house 1-164 (182) alignment 
Range on Protein: 75-311
Range on HMM: 1-164/182.0
NKRFNRHMDVLPHPETRvqlptigndpASAYINANYVHGPSGSDReYICAMGPLPATLKNWWRMIWQEKVTCILMATglvekgtkkCERYWApkpgqkvk
|.  ||..|.|| . .|           . |||||.. |.  ..| .|.. |||. |. ...||......|.|...|         .|.||.        
nldknrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp........

vadmfvrtlatsqgdgyvrtlleiehtSGESRKVMHFWYNTWPDHGVPRtpdgKPDASNLLYMIRDskrsekelnQGGPVLTHCSAGVGRSGTIIALDYI
                           . . | .....|  |||||||      ... ... ....         .||||| ||||||||.||..|....
...........................ellerlgiqylylpwpDhgvpd....ldelldfieevle.........eggpvlVHCsaGvgRtgtlvaaylm

CRLletnkHADLNLVIEEIRRDRVALVQHPQQYELAH
..|     . .|  .....|. |   |..|.|| . .
kkl.....gvsleeavklvrsrRpgmvitpnqyfflq
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 75-223 3.1e-32 106.6 In-house 31-181 (297) alignment 
Range on Protein: 75-223
Range on HMM: 31-181/297.0
N--KRFNRHMDVLPHPETRVQLptIGNDPASAYINANYVHGPSG-SDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPKPGQ
|   | ||. |.|   .|||.|   .  . . ||||.||  |   .|  ||.| ||| ||....|...... |  | | . | | | .||  ||    ..
nsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe

KVKVADMFVRTLATSQGDgYVR---TLLEIEHTsGESRKVMHFWYNTWPDHGVPR
. | .|. |  |..   . . |   | |.. .   |||.| |  . .||||||| 
rlkagdvvveflsstsde.fdrviltelqliyr.sesrvvrhvqflswpdhGvps
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 75-318 1.1e-10 35.4 In-house 51-285 (302) alignment 
Range on Protein: 75-318
Range on HMM: 51-285/302.0
NKRFNRHMDVLPHPETRVQLPTigndPASAYINANYVHGPSGSDREYICAMGPLPAT--LKNWWRMIWQEKVTCILMATGLVEKGTkKCERYWAPKPGQK
| ..|.. ||    ...|.|..     .  |.||  |. |. .   ..  .  .  .  . ..|||..|||.. . .. |  |  .   . ..  | |. 
nlkknqsedvpildsnlvklea....epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdy

VKVADMFVRTLATSQGDGYV-RTLLEIE-HTSGESRKVMHFWYNTWPDHGVPRTPDGkpdASNLLYMIrdskrSEKELNQGGPVLTHCSAGVGRSGTIIA
..  .||| .   .. .. . |  .|.  .   .|  ..    . |... ||        . .    .      .|. .   ...     |.|| |....
keygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyae...liktaakv.....fakkikadentvivSknGaGRagaflt

LDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAILYA
|      |...|    . ... || .| . |.  .||   .  ..|| 
lavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 75-221 9.7e-07 22.6 In-house 96-235 (244) alignment 
Range on Protein: 75-221
Range on HMM: 96-235/244.0
NKRFNRHMDVLPHPETRVQLPTigNDPASAYINANYVhGPSGSDREYICAMGPLPATLKNWWRMIWQEKVTcILMATGLVEKGtkkcERYWAPKPGQKVK
|   ||.   ||    || |       . .|||| .| |  |   ||| .  ||  |  ..|.|. . .|  .|.  | ||.     . ||      .  
nswknregaglpfdfnrvplsk..gsmgntyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvn.vlvvlgsveee....deywpdseplewy

VADMFVRTLATSQGDGYVRTLLEIEHTSGESRKVM-HFWYNTWPDHGV
  |. |      .      . ||||    || . .  |    ||  | 
eeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgt
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 76-337 5.4e-36 119.0 In-house 49-300 (439) alignment 
Range on Protein: 76-337
Range on HMM: 49-300/439.0
KRFNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSgSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTkkcerYWaPKPgQKVKV
.  ||. || .   ||| |  |   | | ||||||..|    |. || . ||   | ...||.....|.. |.| | |||        || |   ..|  
qtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....yw.psd.aevcy

ADMFVRTLATSQGDGYVRTL---LEIEHTSGESRKVMHFWYNTWPDHGVPRtpdgkpDASNLLYMIRDSKrSEKELNQGGPVLTHCSAGVGRSGTIIALD
 |. ||.    .   ||      ..   |.   | |..| | .|||. ||       .|| .| ..|  . | .. .. |||. ||||||||.|||||||
gdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpa......qashvldflrain.sandkeeygpvvvhcsagvGrtGtiiald

YICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAILYAQYVQANLDVDE--RAINAPFL
     | .... |.. ... .|..|  .||.  || . .   .   .| .  . .||  . .|| |.
ialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkkefnagfs
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 76-313 1.1e-34 114.4 In-house 56-284 (305) alignment 
Range on Protein: 76-313
Range on HMM: 56-284/305.0
KRFNRHMDVLPHPETRVQLptiGNDPASAYINANYVHGPSGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPKPGQKVKV
.  ||. ||  . .. |.|    . . | || ||||  |   .. .||| |||  |. ..| |. |.||  |.|    || |  || .||    |.|...
itknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel

AD-MFVRTLATSQ---GDGYV-RTLLEIEHTSGESRKVMHFWYNTWPDHGVPrtpDGKPDASNLLYMIRDSKRsekelnqggPVLTHCSAGVGRSGTIIA
   . |  .. |.    |  .  |||.. .. ...  | |. .. ||| |||     |  . .||  || ||          |.. |||||.||.|||.|
ksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvp...pckltslellsairgskv.........pivvhcsagigrtgtiva

LDYICRLLETNKHA-DLNLVIEEIRRDRVALVQHPQQYELAHAG
..||   .  ||..  .  ..  .| .|   .|   ||   |  
ieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrv
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 77-308 6.8e-34 111.8 In-house 58-273 (290) alignment 
Range on Protein: 77-308
Range on HMM: 58-273/290.0
RFNRHMDVLPHPETRVQLPTiGNDpaSAYINANYVHGpsgSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPKPGQKVKVA
. ||. ||     ||| |   | |    |. ||||.|    .  .| . |.| .|  . |||. ||||. | |   |.|.|  |||.|.  | |. .   
kknrykdvvcndktrvilkd.Gyd..GdyvhanyvkG...lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

DMFVRTLATSQGDG--YVRTLLEIEHTSGESRKVMHFWYNTWPDHGVPRTpdgkpdASNLLYMIRDSKRsekelnQGGPVLTHCSAGVGRSGTIIALDYI
.. |     .. |     .||   .  || . |. |.   .|||. |. .      .  || ..|  ..        |||  |||||.||.||..|..  
eitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvals......tlallrtlrilrk......asGpvvvhcsaGiGrtGtfvaievg

CRLLETNKHADLNLVIEEIRRDRVALVQHPQQYE
 ..|   |. ||  ..  .|. |.. ||   || 
lqilldGkeldlldlvralrnsrlnsvqvdiqyl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 77-315 1.4e-32 107.7 In-house 52-278 (301) alignment 
Range on Protein: 77-315
Range on HMM: 52-278/301.0
RFNRHMDVLPHPETRVQLPtigNDPASAYINANYVHGPsGSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPKPGQKVKVA
  .|.  |  .|.| |..    .|   . | ||..  . |  . .|.. |||..| ...| |. | .|  | | .  ||| ..||| | . |...|... 
dkhryptvPckPstavevi...vdGkrvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldig

DMFVRTLATSQ--GDGYVRTLLEIEHTSGE--SRKVMHFWYNTWPDHGVPRTpdgKPDASNLLYMIRDSKRsekelnqggPVLTHCSAGVGRSGTIIALD
   ...  . .   .  ..  ||.| ..|.  .| |.|. |..|.|.|||..   . .  .|. ....|..         |.. |||||.||| . |. .
rfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPks...haelfdlmelvkksek.........PivvhcsaGiGrsvafigte

YICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAI
|. | .|...  .|.  ....| .|   ||. .|      |..
ylareveadptieltealkhlrehrwngvqtnsqlywmtlGtv
subfamily_egg_pd Subfamily egg 78-315 2.2e-16 54.4 In-house 43-267 (307) alignment 
Range on Protein: 78-315
Range on HMM: 43-267/307.0
FNRHMDVLPHPETRVQLPTIGNDPASAYINANYVHGPSGSdREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKgtKKCERYWAPKPGQKVKV--
  |   |  .  .||.|       .  .| ||.|.|      |.|.|  ||  | ...|||..||.|  |.| |  .|   ..|| ||   . . ...  
karskrvhckdssrvklelrrGqylddfihanrvkGkpll.nefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvp

ADMFVRTLATSQG-DGYVR-TLLEIEHTSGESRKVMHfWYNTWPDHGVPRTPdgkpdasnlLYMIRDSKrsekelNQGGPVLTHCSAGVGRSGTIIALDY
  . . .|   .  |   | | | .  .  | | . | |   .   .   .|         | ..|  .      |   ||. ..  || ...|..|.. 
GslrienlkvdskadplfrvtklklvGgddeerfleh.wqgdvnnssdvysp.........lrvlrklr......nlskpvvvqdilGvskaatlvaiei

-ICRLLETNKH-ADLNLVIEEIRRDRVALVQHPQQYELAHAGAI
 .. ||        .   .  .|. |   |. . .| . .   .
allsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 78-148 7.7e-08 26.2 In-house 48-114 (347) alignment 
Range on Protein: 78-148
Range on HMM: 48-114/347.0
FNRHMDVLPHPETRVQLPTignDPASAYINANYVHGpSGSDREYICAMGPLPATLKNWWRMIWQEKVTCIL
..    |.  ||   . ..   |.. .|||| ...    ...||| .  ||| |....|.|.   ||| ..
lidatrvvlspeksknsra...ddvetyinashikf.dnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv
0044763 (Phosphotyrosine protein) phosphatases II 86-308 7.1e-29 96.1 In-house 1-161 (178) alignment 
Range on Protein: 86-308
Range on HMM: 1-161/178.0
PHPETRVQLPTIGNDPASAYINANYVHgpsgsDREYICAMGPlpatlKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPKPGqkvkvadmfvrtlat
| ..||| |... . ..| ||||...      .. |... .|      ...........|.|.. |. .| |  || .||  . |               
pldrtrvllsnleglersdyinaseil.....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

sqgdgyvrtlleiehtsgesrkvMHFWYNTWPDHGVPRTPDGKPDASNLLYMIRdskrseKelNQGGPVLTHCSAGVGRSGTIIALDYICRLletnkHAD
                       ... .  .||||||  ..  ... ...  ..      .  ..||||| |||||||||||..|......|     . .
.......................iqylhipipDhgvpdllehflefvefieeal......d..ekggpvlVHCsaGvgRsgtlvaaylmkkl.....gls

LNLVIEEIRRDRVaLVQHPQQYE
|. .||..|. |   |..| |..
leeaielvrerRp.ivpnpgqlr
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 87-326 7.4e-24 79.4 In-house 30-267 (290) alignment 
Range on Protein: 87-326
Range on HMM: 30-267/290.0
HPETRVQLPTIGNDPASAYINANYVHGPSGSdrEYICAMGPLPAT-------LKNWWRMIWQEKVTCILMATGLVEKGTK----KCERYWAPKPGQKVKV
  .||| |   |.  .. || ||.|  |.|   . |    |. ..       ....| |. ||||. . |     || ..     |..|   . |...|.
veatrvvLkgygkrfnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkf

ADMFVRTLATSQGDGYVRTLLEIEHTSGESRKVMHFWYNTWPDHGVPRTPDGkpdASNLLYMIRDSKrsekelnqgGPVLTHCSAGVGRSGTIIALDYIC
 .. |.     . |.  .  |....  .|  .| | ... | .  |....     . .|. ... ||          ||. ||  |. || .. |..  .
kgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtkt...llsliqkvkask.........tpvivHcvdGiSrsAalaaiilgy

RLLE-TNKHADLNLVIEEIRRDRVALVQHPQQYELAHAGAILYAQYVQANLD
 ..  |...  |. |....|. |  ........  . ||..|.|. |. .  
Qkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfa
0046846 (Phosphotyrosine protein) phosphatases II 97-311 1.7e-34 114.4 In-house 6-166 (176) alignment 
Range on Protein: 97-311
Range on HMM: 6-166/176.0
IGNDPASAYINANYVHGPsgsdrEYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPKPGQKVkvadmfvrtlatsqgdgyvrtll
.| |. . |||||.. |.      .|.  |||| || ....|......|.... | .||.|  || .||    . ..                       
lgldldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

eiehtsgesrkvmHFWYNTWPDHGVPRTpDGKPDASNLLYMIRdskrsekelNQGGPVLTHCSAGVGRSGTIIALDyicrLLETNKHADLNLVIEEIRRD
             ....  |||||||   .  ... ....  .         ..||||| |||||.||.||..|..    |||..|. ... .....|. 
.............qylhlpwpDhgvpdl.elllellefireal.........keggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreq

RV-ALVQHPQQYELAH
|    ||.|.||.  .
RplgavqtpeQyrfly
0043147 (Phosphotyrosine protein) phosphatases II 100-311 6e-35 115.9 In-house 2-154 (172) alignment 
Range on Protein: 100-311
Range on HMM: 2-154/172.0
DPASAYINANYVHGPSGSDReYICAMGPLPATLKNWWRMIWQEKVTCILMATGLvekgtkkcerywapkpgqkvkvadmfvrtlatsqgdgyvrtlleIE
|. | ||||.|....   || .|.  |||. ||   |||......|.|...|.|                                              
degsdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel............................................ly

HTSGESRKVMHFWYNTWPDHGVPrTPDGKPDASNLLYM--IRDSkrsekelnqGGPVLTHCSAGVGRSGTIIALDYICrlletnKHADLNLVIEEIRRDR
 .....| .....|  ||||||| ...  ... ....   ....         ||||| ||||||||.||..|.....      .. .|  .....|. |
dpellerlgiqylylpwpDhgvp.llellleflefidellalsp.........ggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekR

VALVQHPQQYELAH
   ||.|.|| . .
pgavqnpsqyrfly
0051429 (Phosphotyrosine protein) phosphatases II 102-318 5.1e-42 139.7 In-house 3-225 (272) alignment 
Range on Protein: 102-318
Range on HMM: 3-225/272.0
ASAYINANYVHGPsGS---DREYICAMGPLPATLKNWWRMiWQEKVTCILMATGLVEKGTKKCERYWA----------PKPGQKVKVADMFVRTLATSQG
 | ||||..| |. |.   .. .... ||||.| ...||. .......|.. ....|.|  ||.|||.          .   . . . ...|..| ... 
lsgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

DGYVRTLLEIEHT--SGESRKVMHFWYNTWPDHGVPRTPdgkpdASNLLYMIRDskrsekelnqGGPVLTHCSAGVGRSGTIIALDYICRLLETNKHAD-
. |. . |.....   ||.|.|||..|  |||||||. .       .|| ...|          ||||| |||||..|.||..||... . .. .  .| 
ldyilrellltlllsagearevmhlhytdwpdhgvpqea.....llellellld..........ggpvlvHCsaGkdRTGtvvallllllgvsletivdd

-------LNLVIEEIRRDRVALVQHPQQYELAHAGAILYA
       |  ..||.|. | . ||...||.  .  .. ..
Ylltnlyleeaveelraqrpgavqteeqylflyeallell
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 102-220 7.8e-06 20.2 In-house 12-125 (130) alignment 
Range on Protein: 102-220
Range on HMM: 12-125/130.0
ASAYINANYVhGPSGSDREYICAMGPLPATLKNWWRMIWQEKVtCILMATGLVEKGtkkcERYWAPKPGQKVKVADMFVrTLATSQGDGYVR-TLLEIEH
   ||||..| | .|  .||. .  || .|  ..|.|. .  |  .|.  | ||.     . ||      .    |. | ||.  ..  ... . ||||.
gntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryv.nvlvvlgsveee....deywpdsePlewyeediiv.tltdrdefknikasnleies

TSGESRKVM-HFWYNTWPDHG
   || . .  |    ||  |
dlneshqaltmfqisnwpsdg
0036282 (Phosphotyrosine protein) phosphatases II 103-310 4.5e-33 109.8 In-house 2-162 (174) alignment 
Range on Protein: 103-310
Range on HMM: 2-162/174.0
SAYINANYVHGPSGSDrEYICAMGPLPatlknWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPkpgqkvkvadmfvrtlatsqgdgyvrtlleieHTS
| ||||.....   .. ..|.  |||.      |.|......|...| . ..|.|  || .||                                  . .
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lre

GESRKVMHFWYNTWPDHGVPRTPDgKPDASNLLYMIRDSkrsekelNQGGPVLTHCSAGVGRSGTIIALDYICRLLEtNKHADLNLVIEEIRRDRVALVQ
 ..| .....|  ||||||| ..    .. .... .. .       ..||||| ||||||||.||..|.....|.|. ..  |   .. |.|. |   ||
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.......dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvq

HPQQYELA
.|.||.  
tpsQyrfl
0051082 (Phosphotyrosine protein) phosphatases II 103-310 9.1e-26 85.7 In-house 3-145 (151) alignment 
Range on Protein: 103-310
Range on HMM: 3-145/151.0
SAYINANYVHGPsgsdreYICAMGPLPatlkNWWRMIWQEKVTCILMATGLVEKGtkKCERYWAPKPgqkvkvadmfvrtlatsqgdgyvrtlleiehts
| |||..|| |       ...  |||.      ...........|.. ....| |  .| .|.                                     
sdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

gesRKVMHFWYNTWPDHGVPRTPdgkPDASNLLYMIRDskrsekelNQGGPVLTHCSAGVGRSGTIIALDYICrlLEtnkhADLNLVIEEIRRDRVALVQ
   ..|.|...  |||.|.| ..   . . ..| ...|        ...|||| |||||.||.||..||. ..  |      .|. ..||.|. |  .||
...ievlhipildwpdpglplsf...davleflellld........kkngpvlvHCsaGkgRTGtlvalylml..lg....vsleealeeyrlkrpgvvq

HPQQYELA
..||. . 
pnqqflfq
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 103-167 1.2e-12 41.9 In-house 90-155 (349) alignment 
Range on Protein: 103-167
Range on HMM: 90-155/349.0
SAYINANYVHGPS-GSDREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAP
  ||||||.. .    .. ||. . |||.|.......|  ..|  .|  .   |.. .||..||  
ddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 118-309 3.8e-13 44.0 In-house 4-195 (199) alignment 
Range on Protein: 118-309
Range on HMM: 4-195/199.0
DREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPKPGQKVKVADMFVRTLATSQGDGYVRT-LLEIEHT-S-GESRKVMHFWYN
.| ||..  ||  |. ..|.|.|.     |.|      .       ||.       | . . | | . .    |. | |.  . | .   .|.. |. . 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

TWPDHGVPRTpdgKPDASNLLYMIRDSKRSEKElnQGGPVLTHCSAGVGRSGTIIALDYICRLLETNKHA--DLNLVIEEIRRDRVALVQHPQQYEL
.| ..  |           ..     ||. |.|  .  ||. ||| | | .| ..|||   |  |  | .  ||  |   .|. |. ..   |.|..
swkekttpnv...alfvgfvvasrevskkyeqe..kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 118-309 4.4e-13 43.9 In-house 3-194 (198) alignment 
Range on Protein: 118-309
Range on HMM: 3-194/198.0
DREYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPKPGQKVKVADMFVRTLATSQGDGYVRT-LLEIEHT-S-GESRKVMHFWYN
.| ||..  ||  || ..|.|.|.     |.|      .       ||.       | . . | | . .    |. | |.  . | .   .|.. |. . 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

TWPDHGVPRTpdgKPDASNLLYMIRDSKRSEKElnQGGPVLTHCSAGVGRSGTIIALDYICRLLETNKHA--DLNLVIEEIRRDRVALVQHPQQYEL
.| ..  |           ..     ||. |.|  .  ||. ||| | | .| ..|||   |  |  | .  ||  |   .|. |. ..   |.|..
swkekttpnv...alfvgfvvasrevskkyeqe..kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf
0049260 (Phosphotyrosine protein) phosphatases II 119-311 4.6e-32 106.2 In-house 9-143 (152) alignment 
Range on Protein: 119-311
Range on HMM: 9-143/152.0
REYICAMGPLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWapkpgqkvkvadmfvrtlatsqgdgyvrtlleiehtsgesrkvmHFWYNTWPD
.|.|.. ||.| ||...|||... ..|.|.| | |.|.|  |||.|.                                            .. .  |||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwpD

HGVPRTPDGKPDASNLLYMIrdskrsekELNQGGPVLTHCSAGVGRSGTIIALDYICrlletnKHADLNLVIEEIRRDRVALVQHPQQYELAH
||||  ..  ...  ..  .         |..||||| ||||||||.||..|.....      .. .|  ... .|. |   |..|.|... .
hgvpdlsqlllflllfiekl........aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 127-306 5.4e-20 66.0 In-house 99-276 (302) alignment 
Range on Protein: 127-306
Range on HMM: 99-276/302.0
PLPATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPKPGQKVKVADMFVRTLATSQ-----GDGYVRTLLEIEHTSGESR-----KVMHFWYNTW
|   ||. .| .| | .|. .   ...||.. |||  |.. | |...|     |.|.   .      |    .|  .| .  . .      |  . . .|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHGVPRTPDgkpDAsnlLYMIRDSKRSEKElnqggpVLTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQ
|||| |. ..    |   | ...  .   |.      || ||||||||.||..|. |   |  ..| .|| ...  .|. |   ||. ||
pdhGapkeay...ta...ldilkfcesykkn......vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq
subfamily_hpo-7_pd Subfamily hpo-7 129-308 5.2e-14 46.8 In-house 44-217 (263) alignment 
Range on Protein: 129-308
Range on HMM: 44-217/263.0
PATLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPKPGQKVKVADMFVRTlATSQGDGYVRTLlEIEHTSG---ESRKVMHFWYNTWPDHGVPRTP
  |... ...| | | . . | .   |.| .||..|.  .  .| |.|.. | | . .| |  ..|| |.  | |   . ..| |. |. |...  |. .
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvct.tkvqsdvllktl.ellstlgeKkkthtvkhysykgWiekndpela

DgkpDASNLLYMIRDSKrsekElnqggpVLTHCSAGVGRSGTIIALDYI----CRLLETNKHADLNL--VIEEIRRDRVALVQHPQQYE
    .  |.| . |.||    .      .  |||.|.|||      . .     | |.| . ..|.   ..||.|  | . .. | |  
r...eilnilkvarnsk....s......lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLa
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 131-310 1.4e-17 58.6 In-house 40-213 (255) alignment 
Range on Protein: 131-310
Range on HMM: 40-213/255.0
TLKNWWRMIWQEKVTCILMATGLVEKGTKKCERYWAPKPGQKVKVADMFVRTLAtSQGDGYVRTLlEIEHTSG---ESRKVMHFWYNTWPDHGVPRTPDg
|.......| | | . . | . . |.| .||..|.  .  .| |.||. | |   |  |  .||| ||  | |   . ..| |. |. |...  |. .  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.ssadvvlrtl.eitstlgekkkthtvkhysykGWieknaPelar.

kpDASNLLYMIRDSKrsekelnqggPVLTHCSAGVGRSGTIIALDYICR----LLETNKHADLNL--VIEEIRRDRVALVQHPQQYELA
  .  |.| ..||||          .|. |||.|.||| . .  ... .     |.| . ..|.   ..||.|  | . .. | |  ..
..eilnilkvvrdsk..........svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafs
0048179 (Phosphotyrosine protein) phosphatases II 188-310 6.1e-18 60.4 In-house 29-137 (144) alignment 
Range on Protein: 188-310
Range on HMM: 29-137/144.0
GDGYVRTLLEIEHTSGESRKVMHFWYNTWPDHGVPRTPDGKPDASNLLYMIrdskrsekeLNQGGPVLTHCSAGVGRSGTIIALDYICrlleTNKhADLN
| ..| .| |  .   . | ......  |||||||  ..  ... ...  .         |..||||| ||||||||.||..|.. .     ...  .|.
gittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieea.........leeggpvlVHCsaGvgRtgtlvaaylmk....klg.lsle

LVIEEIRRDRVALVQHPQQYELA
 .....|. |   |..|.|..  
ealalvrsrrpgavpnpgqlrfL
0048076 (Phosphotyrosine protein) phosphatases II 191-311 3.5e-19 64.4 In-house 32-136 (145) alignment 
Range on Protein: 191-311
Range on HMM: 32-136/145.0
YVRTLleIEHTSGESRKVMHFWYNTWPDHGVPRTPDGKPDASNLLymirdskrsEKELNQGGPVLTHCSAGVGRSGTIIALDYICRlletnKHADLNLVI
.| .|     .....|......|  |||||||  ..  ... ...         |. |..||||| ||||||||.||..|.. . .     .. .|  ..
tvlnl..tselellerlgiqylylpwpDhgvpdllellleflefi.........eealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleeal

EEIRRDRVALVQHPQQYELAH
|..|. |   |..|.|..  .
elvrsqrpgavpnpgqlrfly
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 194-314 9.9e-13 42.5 In-house 203-340 (350) alignment 
Range on Protein: 194-314
Range on HMM: 203-340/350.0
TLLEIEHTSGESRKVMHFWYNTWPDHGVPRTPDGKPDASNLLYMIRDSKRSEKE--LNQGGPVLTHCSAGVGRSGTIIALDYICR---LLE----T----
.| .|. .. .   |... .. |.| ..   |     | .    . |.  .|.    ... |.| |||||||| ||...||..      ||         
sltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkl

---NKHAD-LNLVIEEIRRDRVALVQHPQQYELAHAGA
   .|  | .. .. |.|. |. .||  .|.   .  .
dvaaktrDlisiivnelrkqrismvqnldqfifiYeal
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 201-298 9.8e-09 29.0 In-house 213-312 (349) alignment 
Range on Protein: 201-298
Range on HMM: 213-312/349.0
TSGESRKVMHFWYNTWPDHGVPRTPDGKPDASNLLYMIRDSKRSEKEL--NQGGPVLTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRV
.. .  ... . .  |.| ..   |     | .    . |.. ... |  .|  ..| ||||| ||.|... ||..  .||  ..    . .. ...| .
avekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDli
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 203-316 2.1e-18 60.9 In-house 86-191 (440) alignment 
Range on Protein: 203-316
Range on HMM: 86-191/440.0
GESRKVMHFWYNTWPDHGVPRTpdgkpdASNLLYMIRDSKRSEKElNQGGPVLTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQ
 ||| . .. |. |||.|||.       |. .| ||.| . |...    ||.| |||||.||.| |||.| | |  . . . |.  .|. .| .|  .||
iesrtlkqyhyqgwpdkgvpkf......agpvlkmiqdvnesqek.agngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvq

HPQQYELAHAgAIL
 |.|| . |  |.|
tpeqyafvhe.avl
PTPc_DSPc_SM00012 207-312 2.5e-26 87.3 In-house 1-101 (105) alignment 
Range on Protein: 207-312
Range on HMM: 1-101/105.0
KVMHFWYNTWPDHGVPRTPdgkpdaSNLLYMIRDSKRSEKELNQGGPVLTHCSAGVGRSGTIIALDYICRLLETN-KHADLNLVIEEIRRDRVALVQHPQ
.|.|..|..|||||||...      ...| ..|. |..... ....||. ||||||||.||..|||.... ||.. |  |.  ...|.|. |  .||  .
tvkhyhytgwpdhgvPees......dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqtee

QYELAHA
||   ..
qylflyr
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 212-322 1.8e-09 31.6 In-house 196-294 (310) alignment 
Range on Protein: 212-322
Range on HMM: 196-294/310.0
WYNTWPDHGVPrtpDGKPDA--SNLLYMIRDskrsekelnqgGPVLTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYEL
 .  ||| |||   | |  .    ||  .|            ||.. |||||..| ....||..    |.  .. |.. |. |....|.  .| . || .
kwpnwpdrgvp...dekchtvpqrllaqvrh...........gpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyli

AHAGAILYAQYVQ
 .   |..|.  .
idrvriifarget
0038934 (Phosphotyrosine protein) phosphatases II 225-308 1.7e-07 26.6 In-house 88-167 (194) alignment 
Range on Protein: 225-308
Range on HMM: 88-167/194.0
PD-G-KPDASNLLYMIRDSKRSEKElNQGGPVLTHCSAGVGRSGTIIALDYICRlletnKHADLNLVIEEIRRDRVALVQHPQQYE
|| |  |. ..||  ..  ..  .| ..|| |. || ||.||.||..|   |.|      . ...  |. .|. |   .......|
pddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiyr.....lgmsaeeAialfrekRpgaipnqdyle
PTEN_1 226-311 2.7e-10 35.4 In-house 105-186 (196) alignment 
Range on Protein: 226-311
Range on HMM: 105-186/196.0
DGKPDASNLLYMIRDSKRSEKELNQGGPVLTHCSAGVGRSGTIIAldyiCRLLETNKhADLNLVIEEIRRDR-VALVQHPQQYELAH
.|.|. | |. .... . . .....|. || || ||.|||||..|    . |....|  . .  .| .|. | .. .. |.| .| .
hgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva....ayLmykgk.ltadeAlelvrekRppgapnspsqerlle
subfamily_CG42327_pd Subfamily CG42327 242-321 1.3e-15 51.9 In-house 239-318 (319) alignment 
Range on Protein: 242-321
Range on HMM: 239-318/319.0
KRSEKElNQGGPVLTHCSAGVGRSGTIIALDYICRLLETNKH-ADLNLVIEEIRRDRVALVQHPQQYELAHAGAILYAQYV
 || .. .. ||.  ||| ||||.|..|| |   | ||..|.  |.  ..  .||||   |.  .|||. .  .  ||...
srsgtr.esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyakkl
PTPc_motif_SM00404 248-289 1.5e-06 23.1 In-house 77-117 (140) alignment 
Range on Protein: 248-289
Range on HMM: 77-117/140.0
LNQGGPVLTHCSAGVGRSGTIIALdYICRLLETNKHADLNLV
 ..|| || || ||| ||.|.|.  |. |  . . .. ...|
ekkggkvlVHCqaGvSRSatliia.Ylmryrqlslaeayefv
DSPc Dual specificity phosphatase, catalytic domain 248-275 6.5e-06 21.1 Pfam-A 70-96 (133) alignment 
Range on Protein: 248-275
Range on HMM: 70-96/133.0
LNQGGPVLTHCSAGVGRSGTIIALdYIC
 ..|. || || ||. ||.|.|.  |. 
eqkgkkvlVHCqaGisRSatliia.Ylm
DSPc Dual specificity phosphatase, catalytic domain 248-275 6.5e-06 21.1 In-house 70-96 (133) alignment 
Range on Protein: 248-275
Range on HMM: 70-96/133.0
LNQGGPVLTHCSAGVGRSGTIIALdYIC
 ..|. || || ||. ||.|.|.  |. 
eqkgkkvlVHCqaGisRSatliia.Ylm
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 251-312 4.8e-10 33.8 In-house 228-289 (297) alignment 
Range on Protein: 251-312
Range on HMM: 228-289/297.0
GGPVLTHCSAGVGRSGTIIALDYICRLLETNKHADLNLVIEEIRRDRVALVQHPQQYELAHA
  ..| |||||||||| ..  | |   |  ..  | . ... .|  |  |||  .|.|| . 
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyd
DUF4200 Domain of unknown function (DUF4200) 641-711 5.7e-06 12.8 Pfam-A 34-104 (126) alignment 
Range on Protein: 641-711
Range on HMM: 34-104/126.0
RQQKESQAALLQAEREQLEAMIRRCKQSKSEAERNAKAIKQRMQAKEEEIRDLTERINHAQSSQLAMREEL
... | . . || . .. . ... ... . .||..|.  |.  . |||||..|.. ... .. . ...|.|
eeelekkqeelqeslvkfnkflkeneakreraekkaeeekkekkekeeeikklkaqleelkaeiekleekl