Gene Myosin-PTP-2 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily Myosin-PTP
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP043_AA protein Get Run
MbreP043_AA_1290-1534 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_CG42327_pd Subfamily CG42327 6-195 2.2e-44 146.4 In-house 8-192 (319) alignment 
Range on Protein: 6-195
Range on HMM: 8-192/319.0
AEEYNAIDMALVSKKRIPPGTSNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQ
|||.. .   . .   .|... . .|. |..| | ||| | .  ||| . |..|.|| ||| |.  |||.| .   .. ||||.||| ..  || .| |.
aeefrdlPqliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdls

EKGREKCARYWPTvlfnEREGLGDMQAGFVNVAVLAGVRSNGYIATKLRIKHDKSDTERIVMHYWFnSWPDHGVPSETGNVVKMLQAVRE
|.| ..||.|.||    .  . .    | . |..  .   . |. . | .|. . .  | . |||.  |.. .||.|   .. ||  ||.
elGikvcaeylPt....ketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 7-267 7e-79 259.8 In-house 9-267 (274) alignment 
Range on Protein: 7-267
Range on HMM: 9-267/274.0
EEYNAIDMALVSKKRIPPGTSNLNRYNNILPNPRTRVRL-SKLNDDDITTYINANYVHGYDGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQ
.|.  . .    ..   .|... |||..||||...|| | |. ..|. ..||||||..|||. . .|.||||| |.|  |||||....... |||.| |.
keflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklk

EKGREKCARYWPtvlfnE-REGLGDMQAGFVNVAVLAGVRSNGYIATKLRIKHDKSdtERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPER--
|. ..|||.|.|     . ..   . . | |.. |   |. |.|  .|| .|. ..  || |.|||. .|||| .| .. ....... |.|  .. .   
eaneqkCavyfP.....daedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenakl

-PWIVHCSAGVGRTGTFITIDIGMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
 | .||||||.|||| ||.|.|..| |.|..  .| .|.  || ||  |||  || |. ...|..|
apvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcly
subfamily_PTPRD_pd Subfamily PTPRD 8-267 1.1e-87 290.0 In-house 28-280 (564) alignment 
Range on Protein: 8-267
Range on HMM: 28-280/564.0
EYNAIDMALVSKKRIPPGTSN--LNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDgAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQ
||. |..   ....      |   |||.||..  ..||.|||.. |. . ||||....||. .. .|||||||...|. |||||||| | ..|||.| |.
eykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkle

EKGREKCARYWPTVlfNeREglgdmQAGFVNVAVLAGVRSNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWI
|||..||..|||.   . .|     . | . | . . .. . |. .....|. ||.  | | .. | |||||||| .. ....... ||... . . |..
EkgkvkchkYWPek..g.te.....tygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPiv

VHCSAGVGRTGTFITIDIGMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
||||||||||||||.||. .. ..| .  .. .....|||.| |||| .||  | .... |.
VhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailea
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 9-267 2.1e-76 252.0 In-house 26-279 (318) alignment 
Range on Protein: 9-267
Range on HMM: 26-279/318.0
YNAI---DMALVSKKRIPPGTSNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDgAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQ
|...   .    | | . |   . |||.|||.  .|||.|..|...  . ||||||. ||  .. .|||.|.| | | .|||||||| |.  |||.| ..
yerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvWeqnsavivmltqee

EKGREKCARYWPTvlfneReglGDMQAGFVNVAVLAGVRSNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWS-DDPERPW
|.|..|..||||      .   | .. | . | .   |... |.  .......... .|.|  | . ||||.|||........... |...  .  ..| 
ergkakvhryWPs.....k...gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpi

IVHCSAGVGRTGTFITIDIGMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
.|||||||||||.||..|| .. ... .  .| .....||. | .|||  .| || |.|| |.
vvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllea
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 11-266 6.9e-68 223.8 In-house 26-274 (281) alignment 
Range on Protein: 11-266
Range on HMM: 26-274/281.0
AIDMALVSKKRIPPGTSNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGAHgTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGRE
||..  ...    .   . |||.||     |||.... ...  | |||||.| ||.| .  ||||||| |..  .||.||||.... |||||   |.|. 
aigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgek.eyiatqgPvPaslvafWqmvweqkvsaivmvtreieagkl

KCARYWPTVLFnereglgDMQAGFVNVAVLAGVRSNGYIATKLRIKHDKSDtERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSD-DPERPWIVHCS
|| ||||           ... | | |  .|  ... ||  |......... .| | .  . .|||||||..| ....  ..|.. .. . . | ..|||
kChrYWPddns.......elkygdvtvkstaeeekatyierkfkleresge.treveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCs

AGVGRTGTFITIDIGMRLL-QERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSE
||||||||.|..|  .. . .|. . .|..... |||.|  |||   | || ||.. .
aGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavld
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 13-267 1.8e-110 363.2 In-house 5-263 (270) alignment 
Range on Protein: 13-267
Range on HMM: 5-263/270.0
DMALVSKKRIPP--GTSNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGRE
|   .|.. .|    ...||||..|||.|.|||||..|..|..|.|||||||.|.||.. .|||..||.|||. .||||.||.....|||.|||.||||.
dkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrk

KCARYWPTvlfnEREGLGDMQAGFVNVAVLAGVRSNGYIATKLRIKhDKSDTERIVmHYWFNSWPDHGVPSETG------NVVKMLQAVREWSDDPER--
||.||||.    |..   ....|...|..|. ....|||.|.||.. .|....|.| |.|.|.|||||||.|..      ...|||.|||..... ..  
kCerYWpa....epkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae

PWIVHCSAGVGRTGTFITIDIGMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
|..||||||||||||.|..||..|||.|.....|..||..|||||.|.||||||.||.||...||
PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 16-267 6.7e-57 187.9 In-house 44-283 (297) alignment 
Range on Protein: 16-267
Range on HMM: 44-283/297.0
LVSKKRIppgTSNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGahgTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGReKCARY
 |..|..     . .||.||||  . ||.|  .|||    |.|| .|.|.      .|.|| | ..|  |||.||.. ... |||.. ..|. . |||||
tvaekkv...nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcary

WPTVLFNEreglgdmqAGFVNVAVLAGVRSNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPS--ETGNVVKMLQAVRE-WSDDPERPWIVHCSAGV
|.    ..         | | | .|.  . .|.|  .| ....|. ..|.|  | | .|||. |.   ..  ..|... ||. .|.  | | .|||.|||
Wsdkgvtt........fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGv

GRTGTFITIDIGMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
|||| ..|||  .   ..    .. .....||..|  .||  || .| |... |.
Grtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlea
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 17-118 8e-12 39.3 In-house 87-180 (244) alignment 
Range on Protein: 17-118
Range on HMM: 87-180/244.0
VSKKRIPPGTSNLNRYNNILPNPRTRVRLSKLNDDdiTTYINANYVhGYDGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKgrekcARYW
| |  . |  |  ||    ||    || ||| .     ||||| .| |  |    || || |   |. |||.|. |   | .|..  ..|.       ||
vmkdafnpnnswknregaglpfdfnrvplskgsmg..ntyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deyw

PT
| 
pd
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 21-267 7.7e-31 102.1 In-house 28-258 (267) alignment 
Range on Protein: 21-267
Range on HMM: 28-258/267.0
RIPPGTSNLNRYNNILPNPRTRVRLSKLNDDdittYINANYVHGYDGaHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTglqEKGREKCARYWPTVL
 |.    . ||... ||   ||| |.. ...    |||| ||.||     ..|.||.|   |  ||. .. . .   ||..|     . ..  ..||  .
siaeknqernrlddnlpyddtrvilrtkeee....yinasyvegykt.knafivtqdplkntitdfltvihdqkvpvivllt...kvftdnirlfwPPkm

FNEREglgdMQAGFVNVAVlaGVRSNGYIATKLRIKHDKSDTeRIVMHYWFNSWPdhgVPSETGNVVKMLQAV--REWSDDPERPWIVHCSAGVGRTGTF
 . ..     |   |. ..      | |    | .|  .  . . |  |... |    . ..    .| | ..  ..  .. .|| .|.||.||||.|||
gqakk....yqdltvehsl..ekeendyqiitlelkfknesa.hnvtlyyykkwn...intnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtf

ITIDIGMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
..||  .. ... |  .. . .|..|. | ..|.  |.  . ...|.||
lvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
0051299 (Phosphotyrosine protein) phosphatases II 24-267 1.4e-83 276.0 In-house 47-285 (288) alignment 
Range on Protein: 24-267
Range on HMM: 47-285/288.0
PGTSNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGAHGtYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTvlfNE
|   . ||| .|||. ..||.|| |.... ..||||.|..||.  .  .||||||.|.|. |||||||| | . |||.|.|.|.||||||.|||.   ..
penleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl...gg

REGLGDMQAGFVNVAVlagvrSNGYIATKLRIKHD----KSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFI
 . .||..  .... |      ..|. ..|....     .....|.|.|... .|||||||. .  ....|..||..  ... | .||||||||||||||
sltygditvtllseev.....lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfi

TIDIGMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
..|. ...|...|...| |...|||. |. ||| ||| .| |..| ||
aldllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0046845 (Phosphotyrosine protein) phosphatases II 24-267 8.6e-83 273.3 In-house 26-273 (284) alignment 
Range on Protein: 24-267
Range on HMM: 26-273/284.0
PGTSNLNRYNNILPNPRTRVRLSKLNDD-DITTYINANYVHGYD----GAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPT
|   ..||| .|||. ..||.|. |..| . ..||||.||.|||      . ..||||||.|.|. |||||||| |.. |||.|.| |.||||||.|||.
penlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwpl

VlfNEREGLGDMQAGFVNVAVlagvrSNGYIATKLRIKHDK-SDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSD--DPERPWIVHCSAGVGRT
   .|   .||..  .... |      ..|. ..|.... . .. .|.|.|... ||||||||... .....|..|||. .  ... | .||||||||||
e..gevltygdftvtllseev.....kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRt

GTFITIDIGMRLLQERG---RCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
||||..|. ...|...|   ...| |...|||. |. ||| .|| .| |..| ||
GtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealley
0047943 (Phosphotyrosine protein) phosphatases II 24-267 1.4e-76 252.8 In-house 36-271 (273) alignment 
Range on Protein: 24-267
Range on HMM: 36-271/273.0
PGTSNLNRYNNILPNPRTRVRLsklnDDDITTYINANYVHGYDGAHGtYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLFNE
|   ..||| .|||. ..||.|    .|. . ||||.|| ||.  .  .||||||.| |. |||||||| |.. |||.| |.|.||||||.|||.   . 
penkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggel

REGLGDMQAGFVNVAVlagvrSNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDD--PERPWIVHCSAGVGRTGTFITI
 .  |...  .... .      ..|. ..|.... ... .|.|.|... .|||||||. .  .......||..      . | .||||||||||||||..
sltygkftvtllseet.....kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfial

DIGMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
|. ...|...|. .| |....||. |. ||| ||| .| |..| ||
dllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0036941 (Phosphotyrosine protein) phosphatases II 24-267 6.4e-76 250.8 In-house 37-276 (297) alignment 
Range on Protein: 24-267
Range on HMM: 37-276/297.0
PGTSNLNRYNNILPNPRTRVRLsklnDDDITTYINANYVHGYDGAHGtYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLFNE
|.. ..||| .|||...|||.|    ||. . ||||.|| |||  .  .||||||.|.|. |||||||| | ..|||.| | |.||||||.|||.   ..
penleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleeges

REgLGDMQAGFVNVAVLagvRSNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDD--PERPWIVHCSAGVGRTGTFITI
 .  ||..  ...| |     ...|. ..|.... ... .|.|.|... .|||||||. .  .......||.. .   .. | .|||||||||.||||..
lt.ygdftvtllsvevv...llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaa

DIGMRLLQ---ERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
|. ...|.   ..|.... |... ||. |. .|| .|| .| | .| |.
dlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
0043336 (Phosphotyrosine protein) phosphatases II 24-267 3e-75 248.6 In-house 43-276 (278) alignment 
Range on Protein: 24-267
Range on HMM: 43-276/278.0
PGTSNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGAHGtYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPtvlfNE
|   ..||| .|||....||.|| |. |  ..||||.|| ||.  .. .||||||.| |. |||||||| . ..|||.|.| |.||.|||.|||    ..
penkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp....gg

REGLGDMQAGFVNVAVlagvrSNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDI
 .  ||..  .... .      ..|. ..|.... ... .|.|.||.. .|||||||. .  ....|.||||. .|.. | .||||||||||||||....
sltygdftvtllkeeh.....lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyl

GMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
 ...|. .|. .. |....||. |. .|| |.| .| |..| ||
lleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_PTPN9_pd Subfamily PTPN9 24-267 3e-72 238.2 In-house 40-289 (297) alignment 
Range on Protein: 24-267
Range on HMM: 40-289/297.0
PGTSNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGaHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTvlfnE
.. .. |||...|   .||| |.|...|. . |||||.| ||   . ..|||||| . |. |||||||| ..  |||.| . |.|| ||..|||.    |
ranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykq.kkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpl....e

REGlgDMQAGFVNVAVLAGVRSNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVRE------------WSDDPE-RPWIVHCSA
.|    .. |...|...  . .. |  ..| ||. | . .| |.|. | ||||.||||.. .....|..|||            |  .|.  | .|||||
ees..saefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsa

GVGRTGTFITIDIGMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
|.||||||||.|| .  |.| | ..| | ...||. |  ..| ||| || |. . ||
GiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 24-267 2.1e-71 235.6 In-house 46-282 (319) alignment 
Range on Protein: 24-267
Range on HMM: 46-282/319.0
PGTSNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGaHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLFne
.  .. |||.|||.  |||| ||.|.. . ..||||... ||.  .  .||||.|  .|. |||||||| ..  .||.|.|.||.. |. .|||.  |  
eenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqe.rekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenf..

reglgdMQAGFVNVAVLAGVRSNGYIATKLRIKHDKSDT-ERIVMHYWFNSWPDHGVPSETGNVVKMLQAVRE-WSDDPERPWIVHCSAGVGRTGTFITI
      .. | . | ..   . ..||  || ... .|.   | |.|. ...||||.|| ..  ....|. .|. ..   ..| .||||||||||||||..
......eeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivl

DIGMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
|. .  ..| |  .| ....|||  |  |||.||| .| |..| |.
damlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeallea
0045098 (Phosphotyrosine protein) phosphatases II 24-267 3.2e-71 235.2 In-house 31-271 (278) alignment 
Range on Protein: 24-267
Range on HMM: 31-271/278.0
PGTSNLNRYNNILPNPRTRVRlsklnddDittYINANYVHGYdgaHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTvlfNE
.|  ..||| .|||....||.       |   ||||.|..||   . ..||||||.|.|. |||||.|| . ..|||.|.|.|.||||||.|||    ..
lgnldknRykdilpydhsrVk.......d...YINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe...gg

REGLGDMQAGFVNVAVLagvrsNGYIATKLRIKHD----KSDTERIVMHYWFNSWPDHGVPSET--GNVVKMLQAVREWSD-------------DPERPW
 .  ||..  .... ||     . |. ..|.. .     .....| | |... .||||||||..    . ..|. .||. .             |.. | 
sltygdftvtllseevl.....ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

IVHCSAGVGRTGTFITIDIGMRLLqErGRCNVNEIIRRLRKDRCA-MVQHPEQAEFAYKVLSEY
.||||||||||||.. ... ..|| | |.... |... ||. |.  .||..|| .| |..| |.
lVHCsaGvgRtGtlvaaylmlell.e.ggvdlleavkelrsqRpglavqnleqyrflyefllel
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 24-264 7.5e-66 217.1 In-house 45-275 (288) alignment 
Range on Protein: 24-264
Range on HMM: 45-275/288.0
PGTSNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGaHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVlfNE
.   . |||.||||   .||.| ||.. . . ||||.|..|... . .||||||| . |  |||..|.|.... |||.|.| |.|..|| .|||.   ..
avnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekk.kkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPda..dk

reglgDMQAGFVNVAVLAGVRSNGYIATKLRIKhdKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDI
       . | |.| ..     . ..  || ..  |. ||. . .| . .|||||||  . .....|. |   ...   | |||||||||||||||..| 
.....pknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialda

GMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVL
 .  ..|    .| ... .||| |  .||  .| || |.||
lidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevl
subfamily_PTPN1_pd Subfamily PTPN1 24-263 6.5e-53 174.3 In-house 30-266 (290) alignment 
Range on Protein: 24-263
Range on HMM: 30-266/290.0
PGTSNLNRYNNILPNPRTRVRLSKLNDdditTYINANYVHgYDGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVlfNE
|   ||||| .. |   .|..| . .      ||||. |.  . |.  || |||| | |.  ||.|||| .. ..||.  . ||.. |||.|||.   .|
penrnlnryrdvspydhsrikleradn....dyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqg..ee

REGLgDMQAGFVNVAVLAGVRSNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWS--DDPERPWIVHCSAGVGRTGTFITI
 . |  ..   ..| ...  |.. |.  .|...  |..  | ..|. . .||| |||.  .. .|.|. |||     .   | ..|||||.||.|||. .
ekel.lledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclv

DIGMRLLQERGR---CNVNEIIRRLRKDRCAMVQHPEQAEFAYKV
|  . |.....    ..... .  ||| |  ..| ..| .|.|  
dtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsyla
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 24-267 3.3e-52 172.2 In-house 44-282 (290) alignment 
Range on Protein: 24-267
Range on HMM: 44-282/290.0
PGTSNLNRYNNILPNPRTRVRLSKLNDD-D-ITTYINANYVHGYDGAHgTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVlf
.  ..|||..||...   |. | ..... |    |||| |..||  ..  |||||||.. |  |||...|. .   |||.|  .|.|..||  |||.   
ssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekk.qyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..

NEReglgDmqAGFVNVAVLAGVRSNGYIATKLRIKHDKS-DTERIVMHYWFNSWPDHG-VPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFI
. .    .   | ... .|     |.|| .||..|...| .....|..| . .|...| |. ... .. . . ..    . ... .||||..|||...|.
dtk....a..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfc

TIDIGMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
......   .  |  .| ......|  .  .||  .| .. .... .|
aaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 24-267 2.2e-47 156.8 In-house 46-287 (325) alignment 
Range on Protein: 24-267
Range on HMM: 46-287/325.0
PGTSNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGaHGTYIATQGPTPTTTPDFWRMV--WEtnaNSIVMVTGLQEKGREKCARYWPTVLF
|   . ||..|...  ..|| |  ..||  . ||||.|.. . .   ...|.| | ..|. |.||.|  |.    |.|.|.   ..| ..|| |||  . 
penkaknrfknvvaldksrvvletkkddpssdyinasylrddkk.kdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavywpkemg

NereglgDMQAGFVNVAVLAGVRSNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDD------PERPWIVHCSAGVGRT
.        . | ..| . .      |.  .| .|  |    | |  . . ||.| ||.     .. .|| | . |.          | .||||||||||
k......sktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrt

GTFITIDIGMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
|.||..   .  . |  | .. . ...||||| .||.  .|  . |. | |.
Gvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 24-189 6.1e-38 125.4 In-house 31-189 (297) alignment 
Range on Protein: 24-189
Range on HMM: 31-189/297.0
PGTSNLNRYNNILPNPRTRVRLSKLNDDdiTTYINANYVHGYDGAHG-TYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLfN
...   |||..||    |||.| .   .  . ||||.||   |  .   || .|||. .|  |||..|.| . . ||||. ||| ||.||| ||| |  .
nsslrknryrdilatddtrvkllrvite..rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv.q

EREGLGDMQAGFVNVAVLAgvrSNGYIATKLRIKHDksDTERIVMHYWFNSWPDHGVPSETGNVVKM
||   ||.   |.          .  | |.|.. .   . .| | |  | |||||||||.  ..|..
erlkagdvvveflsstsde...fdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrf
0050432 (Phosphotyrosine protein) phosphatases II 25-267 5.5e-83 274.1 In-house 67-298 (308) alignment 
Range on Protein: 25-267
Range on HMM: 67-298/308.0
GTSNLNRYNNILPNPRTRVRLsklndDDITTYINANYVHGYD-GAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLFNE
   ..||| .|||. ..||.|     |. ..||||.||.||. .   ..||||||.|.|. |||||||| | . |||.| |.|.||||||.|||. | ..
enkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelggg

REGLGDMQAGFVNVAVlagvrSNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSddPERPWIVHCSAGVGRTGTFITIDI
 .  |...  .... |      ..|. ..|.... ... .|.|.|... .|||||||...  ....|..||..   |. | .||||||||||||||..|.
sleygkftvtllseev.....lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdl

GMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
 ...|.. |...| |....||. |. ||| ||| .| |..| ||
lleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralley
DSPc_SM00195 25-267 3.5e-77 254.6 In-house 25-261 (263) alignment 
Range on Protein: 25-267
Range on HMM: 25-261/263.0
GTSNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYdGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLfNER
  .. |||.||||. .|||.|.| .... ..||||||. |.     .|||||||.|.|  ||||||||.. . |||.|  .|.|.|||.||||    .. 
knksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees.ggk

EGLGDMQAGFVNVAVLAgvrsNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDIG
|  |...  .|.|        . .| ..|...... ...| | .|....|||||||..| .|...|.||.....  . | .|||||||||||||.|||| 
etfgkisvklvevekkk....deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidii

MRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
.. |.|  . .. ||...||| |. |||  ||  |.|... ||
lskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 25-267 3.5e-77 254.6 In-house 25-261 (263) alignment 
Range on Protein: 25-267
Range on HMM: 25-261/263.0
GTSNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYdGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLfNER
  .. |||.||||. .|||.|.| .... ..||||||. |.     .|||||||.|.|  ||||||||.. . |||.|  .|.|.|||.||||    .. 
knksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees.ggk

EGLGDMQAGFVNVAVLAgvrsNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDIG
|  |...  .|.|        . .| ..|...... ...| | .|....|||||||..| .|...|.||.....  . | .|||||||||||||.|||| 
etfgkisvklvevekkk....deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidii

MRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
.. |.|  . .. ||...||| |. |||  ||  |.|... ||
lskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_PTPRN_pd Subfamily PTPRN 25-265 1.5e-42 140.3 In-house 55-289 (297) alignment 
Range on Protein: 25-265
Range on HMM: 55-289/297.0
GTSNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTvlfner
 . . ||....||   .||.|.. .... . ||||  .   |  . .||||||| ..|  |||.||||  .  ||..| |.|.| ..|.||||       
knvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpd......

EGLGdmQAGFVNV-AVLAGVRSNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDI
||      .. .|  |   . .. |.   . .|  ...  | |  . | |||..|||... ..... . |         | .||||.|.||||..| ||.
eGse..vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidl

GM-RLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLS
 . |||.   . ..   .  || .|  .|.  .| |||.....
vlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
0040438 (Phosphotyrosine protein) phosphatases II 26-267 3.6e-79 261.6 In-house 43-275 (317) alignment 
Range on Protein: 26-267
Range on HMM: 43-275/317.0
TSNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGAHGtYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTvlfNERE
  ..||| .|||....||.|| |. |  ..||||.||.|..  .  .||||||.| |. |||||||| . ..|||.| | |.||||||.|||.   .|  
nkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl...getl

GLGDMQAGFVNVAVlagvrSNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDIGM
  ||..  .... .      .|.. ..|..........|.|.|... .|||||||. .  ....|.||||. .||. | .||||||||||||||.... .
tygdftvtllseee.....lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylml

RLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
..|...|...| |....||. |. .|| ||| .| |..| ||
eqlekeggvdveeavkelreqRpgavqtpeqyrflydalley
subfamily_PTPRB_pd Subfamily PTPRB 26-262 2e-75 248.6 In-house 51-279 (293) alignment 
Range on Protein: 26-262
Range on HMM: 51-279/293.0
TSNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGAHgTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVlfnere
 .. |||.||||   .||.|..|.|.. . ||||||..||   .  .|||||| |.|. ||||||||.... |||.| | |||..|| .|||.       
nraknrytnilpydhsrvkLaalkdesgsDYinanyipgynspr.efiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad......

gLGDMQAGFVNVAVLAGVRSNGYIATKLRIKHdkSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWS--DDPERPWIVHCSAGVGRTGTFITIDI
   ... | ..| ..|  . . ..  .|.|..  ...|| |..| | ||||||||..| ........|||.   .  .|| .||||||||||||||..| 
.eepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdr

GMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYK
 .. ..|.   ..  |. .||..|. .||  .|  | ..
llqaieeedyvdifgivaelReeRnllvqtekqYifihq
0045450 (Phosphotyrosine protein) phosphatases II 26-267 6.5e-74 244.7 In-house 55-303 (307) alignment 
Range on Protein: 26-267
Range on HMM: 55-303/307.0
TSNLNRYNNILPNPRTRVRLSKLNDD-DITTYINANYV--------HGYDGaHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYW
  ..||| .|||...|||.|| |... . . ||||.||        .|||    ..||||||.| |  |||||.|| . . |||.|.| |.||||||.||
nkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqyw

PTVlfNEREGLGDMQAGFVNVAVlagvrSNGYIATKLRIKHD-KSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDD--PERPWIVHCSAGVG
|.   .|    |...  .... .      .||. ..|....  ... .|.|.|... .|||||||. .  .......||.. ..  .. | .||||||||
Pde..geeltygnftvtllseeh.....ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvg

RTGTFITIDIGMRLLQERGR---CNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
||||||.... .|.|...|    ... |....||. |. .|| ||| .| |..| |.
RtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_PTPN6_pd Subfamily PTPN6 26-267 1.4e-68 226.1 In-house 54-296 (306) alignment 
Range on Protein: 26-267
Range on HMM: 54-296/306.0
TSNLNRYNNILPNPRTRVRLSklNDDDI-TTYINANYVH-GYDGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLFNE
  . |||.||||   ||| |.  ... . ..||||||..    | . .||||||  .|| .|||||||. |.. |||.|   |.|.||||||||..  .|
nkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeeke

RegLGDmqagfVNVAVLAGVRSNGYIATKLRIKH-DKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPE----RPWIVHCSAGVGRTGTF
.   |.     ..|  ..  . . ||  .|.... .|...|| |..| |.||||||||...| |...|. |.. ... |    .| .||||||.||||||
e..yGk.....isvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtf

ITIDIGMRLLQERG---RCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
| ||| ..|....|    ........ .|. |  .||  .|  | ||....|
iviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky
subfamily_PTPN12_pd Subfamily PTPN12 26-266 2.5e-66 218.5 In-house 40-275 (290) alignment 
Range on Protein: 26-266
Range on HMM: 40-275/290.0
TSNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGAHgTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLfNERE
. . ||| .|||   .|| ||| ....   |||||...| .| . .|||.||| |.|  |||||.||.| . .||.  . | |. ||.||||    .|. 
nvkknrykDilPydksrvelskieeeegsdYinanfikgvegkl.eyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeeg.eeel

GLGDMQAGFVNvavlAGVRSNGYIATKLRIKHDksDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDIGM
  |...    .        .....   |.....  ...|.|  . ...|||||||| . ........|||  .. . | .|||||||||||| |.||.  
efgefevtlee....ekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvr

RLLQERGR---CNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSE
.||...      .| .....|||.| |.||  || |. || . |
ellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae
subfamily_PTPN13_pd Subfamily PTPN13 26-264 5.5e-66 217.6 In-house 37-265 (273) alignment 
Range on Protein: 26-264
Range on HMM: 37-265/273.0
TSNLNRYNNILPNPRTRVRLSKLNDddittYINANYVHGYDG-AHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLFNER
  . ||| |.||  .|||.|..        ||||....   |  . .|||.||| |.|. |||.|||| .|. |.|||  .|||. || ||||    .. 
nkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkkl

eglgdMQAGFVNVAVLAGVRSNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDdPERPWIVHCSAGVGRTGTFITIDIG
     .  . ..|..|  .. .|.   .| .|. .|   | |.|  | .||||||||.. ....... ||.  .  . | .||||||.||.||.||||. 
.....kvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvv

MRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVL
. |..     .|.||.|.||. | ..||  .|  | ||..
lglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_PTPRG_pd Subfamily PTPRG 26-266 2.8e-65 215.6 In-house 47-285 (563) alignment 
Range on Protein: 26-266
Range on HMM: 47-285/563.0
TSNLNRYNNILPNPRTRVRLSKLNDDDIT-TYINANYVHGYDGAHgTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTvlfNER
  . ||| ||..  |.||.||.| . . .  ||||||..||  ..  .|||||| ..|. |||||.|| |.. |||.| |.|.||.|| .|||.   .| 
nkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqksk.afiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk...des

EGLGDMQAGFVNVAVLAGVRSNGYIATKLRIKHDKS-DTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDI
| .| .|   ..  |||   ..  .  .|..|. |. |||. |..| . .|||||||. .  |... .       .   | .||||||||||||.| .| 
etygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldt

GMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSE
 .. .|..   || ......|  |  .||  ||  | ...| |
llkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalle
subfamily_PTPRK_pd Subfamily PTPRK 26-266 1.5e-62 206.2 In-house 43-275 (314) alignment 
Range on Protein: 26-266
Range on HMM: 43-275/314.0
TSNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGAHgTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPtvlfNERE
  . ||...||.  |.||.|  ...|  . ||||... .|  ..  .|.|||| . |. ||||.|.. |. ||||.| |.|.|| || .|||    .. |
nreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpa.afivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP....edte

GLGDMQAGFVNVAVLAGvrsngYIATKLRIKH--DKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDI
  ||..  .|.. .||      ...  .|...   . .  |.| .. | .||||.|| .   ..|... | ..... . . .|||||| |||||||.|||
vygdikvelvetellae.....lvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidi

GMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSE
 . .....|  .| .... ||. .  ||.  ||  | | |. |
vldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 26-267 1.4e-61 202.9 In-house 9-241 (250) alignment 
Range on Protein: 26-267
Range on HMM: 9-241/250.0
TSNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGAhGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREkCARYWPTvlfNERE
  . ||| .|..   .|| | | . |... |||| ..||||.   ..|||||| ..|. ||||||.| ....|||.| |.|.... . .|||.   .. |
nkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv...ekae

glgdmQAGFVNVAVLAGVRSNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDD-PERPWIVHCSAGVGRTGTFITIDIG
     . | | | .|       |. .|| . . |   |||| .. | .||| ||| ..  |...|. |.   .   ..| ||.|||||||.|.||.||  
.....kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

MRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
.  |..    .| ..|..|||||  .|.  ||  | |... ..
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_PTPN14_pd Subfamily PTPN14 26-267 2.2e-55 182.8 In-house 49-295 (300) alignment 
Range on Protein: 26-267
Range on HMM: 49-295/300.0
TSNLNRYNNILPNPRTRVRLSKLNDDdITTYINANYVHG-YDGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLFNER
  . ||....||   .||.||  ...  | ||||  ..    |.. .||..||| ..|  |||.||||.. . |||.|  .|.|.||. .|.|    ...
naeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkk

eglgDMQAGFVNVAVLAGVRSNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVK---MLQAVREWSDDPE------RPWIVHCSAGVGRT
     .. |  .|       |. .|.|.|..||  |  || |.|  .. |||||||..  . ..   ..|.||. ...         | .||||||||||
....tvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrt

GTFITIDIGMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
|  |. |. .  |.   . .......|||. |  .||   | .| |||| .|
GvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 26-266 5e-49 161.8 In-house 47-276 (287) alignment 
Range on Protein: 26-266
Range on HMM: 47-276/287.0
TSNLNRYNNILPNPRTRVRLSklndDDITTYINANYVHGYDGAHgTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTvlfneRE
  ..||...||.    || |     .    |||| .. ||  ..  .|....|   |  .||..... | . |||.. ..|. .|.| .|||.      .
nkdknRltqilvpdnyrvllk....gehpdyinavfidgykekk.afiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpe.....ek

GlgdMQAGFVNVAVLAGVRSNGYIATKLRIKHDKSD-TERIVMHYWFNSWPDHG-VPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDI
    .  |  |...|   ...|||  ||..|..... ... |. | . .|...| |..    .. . . ...     . . .||||..|||...|. ...
s...vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaat

GMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSE
...  .. |  .| ..... |  .  .||  || .| .... |
tinkckteGviDvfqvlksqriqkpgsvqtveqykfindivle
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 26-77 1.2e-06 22.6 In-house 46-95 (95) alignment 
Range on Protein: 26-77
Range on HMM: 46-95/95.0
TSN--LNRYNNILPNPRTRVRLSKLNDDDittYINANYVHGYDgAHGTYIATQG
 .|   ||. ||.|   ||| |.   | |   |||| .| ||   .  |||.||
eanipknrflnifpydatrvvlttkrdsd...yinacfvdgya.rkncyiaaqg
0039614 (Phosphotyrosine protein) phosphatases II 27-267 2.7e-74 245.6 In-house 57-288 (297) alignment 
Range on Protein: 27-267
Range on HMM: 57-288/297.0
SNLNRYNNILPNPRTRVRLSKLND-DDITTYINANYVHGYDGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGReKCARYWPTVLFnere
 ..||| .|||....||.|. ... |  ..||||.|| |||    ..||||||.| |. |||||||| . ..|||.| | |.|| |||.|||.       
kdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg....

glgdmQAGFVNVAVLAGVRSNGYIATKLRIKHdkSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDD--PERPWIVHCSAGVGRTGTFITIDI
     . | . | .|     .||. ..|....  .. .|.|.|... .|||||||. .  . ..|..|||.     ...| .||||||||||||||....
.....tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaayl

GMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
 ...|...|. .| |....||. |. .|| |.| .| |..| |.
mleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
0040439 (Phosphotyrosine protein) phosphatases II 27-267 9.6e-72 236.8 In-house 12-245 (249) alignment 
Range on Protein: 27-267
Range on HMM: 12-245/249.0
SNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGAHGtYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTvlfNEREG
 ..||| .|||....||.|| |..   . ||||.|..||.  .  .||||||.| |..|||||.|| . ..|||.| |.|.||||||.|||.   ..   
kdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl...ggsle

LGDMQAGFVNVAVlagvrSNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDD--PERPWIVHCSAGVGRTGTFITIDIG
 ||..  ...| |     ...|. ..|.... . ...| |.|... .|||||||. .  ......|||.. ..  .. | .||||||||||||||.... 
ygdftvtllsvev.....kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

MRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
...|..... .. |... ||. |. .|| ||| .| |..| |.
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0042113 (Phosphotyrosine protein) phosphatases II 27-267 1.4e-71 236.1 In-house 10-242 (245) alignment 
Range on Protein: 27-267
Range on HMM: 10-242/245.0
SNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGAHGtYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTvlfNEREG
 ..||| .|||...|||.||  . |  ..||||.||.||.  .. .||||||.| |..|||||.|| . ..|||.| . |.||.|||.|||.   .|   
kdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl...geslt

LGDMQAGFVNVAVlagvrSNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSD-DPERPWIVHCSAGVGRTGTFITIDIGM
 ||..  .... .      ..|. ..|.......| .| |.||.. .|||||||. .  ....|..||..   |.. | .||||||||||||||.... .
ygdftvtllseeh.....lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

RLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
..|..... .. |....||. |. .|| |.| .| |..| |.
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
0037934 (Phosphotyrosine protein) phosphatases II 27-267 8.4e-69 227.1 In-house 11-241 (243) alignment 
Range on Protein: 27-267
Range on HMM: 11-241/243.0
SNLNRYNNILPNPRTRVRLsklndDDiTTYINANYVHGYDgahgTYIATQGPTPTTTPD----FWRMVWETNANSIVMVTGLQEKGREKCARYWPtvlfn
 . ||| .|||....||.|     .. . |||||.. ...    ..||||||.| |. |    ||||.|| . ..|||.| |.|.||||||.|||     
lsknrysdilpydhsrvkl.....eg.sdyinanliyvtp....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.....

ereglGDMQAGFVNVAVLAGVRSNGYIATKLRIKHDK-SDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREW--------SDDPERPWIVHCSAGVG
     |... | . | .|     ..|. ..|.... . .| .| |.||.. .|||||||... .....|..|||.         .|...| .||||||||
.....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGTFITIDIGMRLLqergRCNVNEIIRRLRKDRCA-MVQHPEQAEFAYKVLSEY
||||.|.... ..||    .... |....||. |.  .|| |.| .| |..| |.
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 27-267 3.2e-68 225.1 In-house 47-282 (305) alignment 
Range on Protein: 27-267
Range on HMM: 47-282/305.0
SNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGAhGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLFNEREg
 . ||...| . .  |..|.. ...| . ||||.||.||..   .||..||| ..|  ||||...|.  ..|||.|.|.| |..|| .|||.   ...| 
kaknrlkeitlldddriiltekeslddsdyinasyvdgykrk.kkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekke.

LgdmqaGFVNVAVLAGVRSNGYIATKLRIKH-DKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVR-EWSDDPERPWIVHCSAGVGRTGTFITIDIG
.     | ..| .      ..||  ||.|   |... .| |..| . .||||||| ... ...... |. ... | . | .|||||||||||.||..|| 
f.....gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdia

MRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
.  |.. .  .| |....||. |  |||  .|  | . .| |.
lerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldel
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 27-267 3.1e-65 215.4 In-house 57-289 (298) alignment 
Range on Protein: 27-267
Range on HMM: 57-289/298.0
SNLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGAHgTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVlfnereg
 . ||| .|..   .||.|.| ..|....|||| ..|.|.| . ..||||.| ..|. ||||||.| ....|||.| |.|... |. .|||..       
kkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPde.......

lGDMQAGFVNVAVLAGVRSNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPE-RPWIVHCSAGVGRTGTFITIDIGM
 |  . | ..| .|.  .   .| .|| ... |...|| | .  | ||||.|||...  |...|. || .  .   .| ||.|||||||.|||| ||  .
.gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvl

RLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
  ...     | .....|||.|...||  ||  | |..  |.
ervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_PTPN3_pd Subfamily PTPN3 27-260 1e-60 200.0 In-house 42-267 (280) alignment 
Range on Protein: 27-260
Range on HMM: 42-267/280.0
SNLNRYNNILPNPRTRVRLSKLNDDdittYINANYVHGY-DG--AHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTvlFNE
 . ||| .|||   |||.|.. . |    |||||||    ..  .   ||||||| ..|. |||.|||| ... |||.| | |.|| || .|||.   ..
lsknryrdilpydatrvklkesetd....yinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe..ted

ReglgdMQAGFVNVAVLAGVRSNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDI
.     .. |  .| .    ... |.  .| .|. ... || ...  . .|||||||... ....... ||.     |.| .||||||.|||| .|....
e.....leygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlillet

GMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFA
 . |....   .. .|.|..|  | ..|| ..| .| 
alalieaaepvypldivrtmrdqramlvqtasqykfv
subfamily_PTPN23_pd Subfamily PTPN23 27-264 1e-54 180.3 In-house 44-276 (288) alignment 
Range on Protein: 27-264
Range on HMM: 44-276/288.0
SNLNRYNNILPNPRTRVRLSKLNDDdittYINANYVHGYDGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLfNEREG
|. ||...|||  ..|| | . .||    |||| .|..      ..||||.| ..|  |||.||.|  .. |||..  .|.|..|..||||.   .| . 
seknrsrdilPyDhnRvklrgskDD....YinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedk.getvk

LGDmqagfVNVAVLAGVRSNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVRE----WSDDPERPWIVHCSAGVGRTGTFITID
 ||     ..|..    ... ..  .|.... ..|. . |.|  ..|||..|||.  ......|..|..         . | .|||||||||||.|  . 
fgd.....lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvy

IGMRLL-QERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVL
  .| | .. |  .. ....|||..|  |||. || .|.|.. 
aavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 27-266 1.4e-47 156.9 In-house 39-275 (287) alignment 
Range on Protein: 27-266
Range on HMM: 39-275/287.0
SNLNRYNNILPNPRTRVRLSKLNDdDITTYINANYVHGYDGaHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPtvlfnEREG
 . ||| ..||   ||| ||.  .   . ||||||| .|   . ..||.||| ..|  ||||.|.||.. |....|   |..| || .|||     ||| 
vkknryadvlPiddtrvllsaege.lGsdyinanyvasytd.deafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP.....erev

lgDMQA-GFVNVAVLAGVRSNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAV-----REWSDDPERPWIVHCSAGVGRTGTFIT
   |.  |.  |..   ...  |    ||. . ..   |.|  . . ||||....  .  ....   |      . . .   | .||...|.||.|....
..PmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGilla

IDIGMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSE
. . .. |.. || .|  .. |||. | |.|| . |  . |. |  
tlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvt
0049772 (Phosphotyrosine protein) phosphatases II 27-267 2e-46 154.5 In-house 47-279 (314) alignment 
Range on Protein: 27-267
Range on HMM: 47-279/314.0
SNLNRYNNILPNPrTRVRLSKLNDDDiTTYINANYVHGYdgahGTYIATQGPTPTTTPDF----------WRMV--WETNANSIVM--------------
 . ||| .||| . .||.|..|. .. . ||||.||.|.     ..||||||.. |  ||          ||||  .. |   |||              
rdknryldilpad.nrvilpglpvsg.sdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLd

-------VTGLQEKGREKCARYWPTVLfnereglgdmqagfvnvavlagvrsngyiatklRIKHDKSDTERIVMHYWFNSWPDHGVPsETGNVVKMLQAV
        ..| ..| | .|.....                                   .. .|... || ...|.   .||...|  .  . ..|...
aAlgKtpllildgngneptaadlellk.................................eelydpelferlgikylripvpDgsap.lledfdeflefi

REWsdDPERPWIVHCSAGVGRTGTFITIDIGMRLLqergRCNVNEIIRRLRKDRC-----AMVQHPEQAEFAYKVLSEY
.|.  |...| .|||.||.||||||..... |.||    .....|.....|. |       ... .|| || ...| ||
eea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealley
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 27-267 5.7e-44 145.0 In-house 41-292 (301) alignment 
Range on Protein: 27-267
Range on HMM: 41-292/301.0
SNLNRYNNILPNPRTRVRLSKLND--DDITTYINANYVHGYDGAHgTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLfNER
..|||..|| . .  |. |.. ..     ..||||.|..||  ..  .||.|||   |  ||||..|.    ||||||.|.|. ..|| .|||.   .|.
kalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekk.kfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnse.aes

EGLGDMQAGFVNVAV------------LAGVRSNGYIATKLRIKHDKsdTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDP-ERPWIVHCSAG
|  | ..  .|| .|            .  . .||||  |...|.||  . . |. .   .||..||  |   |.. .. |      .   | .||||..
eefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdt

VGRTGTFITIDIGMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
|.|.|......||.   .  |  .| ......|. .  .|.  ||  . |.|...|
VsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 27-259 3.7e-41 135.9 In-house 34-257 (283) alignment 
Range on Protein: 27-259
Range on HMM: 34-257/283.0
SNLNRYNNILPNPRTRVRLSKLNDdditTYINANYVH--GYDGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTvlfner
 . ||...|.|  . ||.|  ..     .|||| ..     .     ||..|.|   |  |||.||.. .. .|||.| |||  |.||..|||       
krknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk......

EglGDMQAGFVNVAVLAGVRSNGYIATKLRIKHDKS-DTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDI
.  | .. |   |..   . || .|  .| .... |  .. .. || .. | . |  .    .||. . .    . .. | .||||.|.|||..||..  
r..GsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasa

GMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEF
 .  ..     .| .... .|..|  .||  .|  .
svkdaltesvvdvfavvkimreqrmmavqtldqykl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 27-266 1.5e-37 123.8 In-house 38-267 (281) alignment 
Range on Protein: 27-266
Range on HMM: 38-267/281.0
SNLNRYNNILPNPRTRVRLSK-LNDDDITTYINANYVHGYDGAHGtYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPtvlfneRE
 . ||| ||     .||.|   . . . | || |||..     .| || ||||   |  |||||.|. |. .|||.  . |  ||||| |.|      |.
nkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrg.yiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfp......rn

GLGDMQAGFVNVAVLAGVRSNGYIATKLRIKHDKsdTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPerpwIVHCSAGVGRTGTFITIDIGM
    .|   . |.       .  ..|.| . ..     |.. |. .. |||  ||  .  ..|.|. .|  |  |    ..||||||||.||.....| .
ahcclqfdklsvsyedstvnkslvttrlnlsyeg..etrlithwlwkewpdwqvpessevmlkilrkirarstpp....vihcsagvgrsgtlmaveial

RLLQER-GRCNVNEIIRRLRK-DRCAMVQHPEQAEFAYKVLSE
. .. .    ....|. .||   |.| ||  .|  . .||| .
qsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 27-267 4.8e-36 119.3 In-house 42-276 (307) alignment 
Range on Protein: 27-267
Range on HMM: 42-276/307.0
SNLNRYNNILPNPRTRVRLSklNDDDITTYINANYVhGYDGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLFNErEG
.. |||...    ..|. .    |   . || |||. |       .|..|||  .|  .|| |. . . .|..|.  . | .. || .||| .  ..   
tdknryqdvkcqdkgrivvk..fdglasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqk.lv

LGDMQAgFVNVAVL---AGVRSNGYIaTKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREwsddPERPWIVHCSAGVGRTGTFITIDI
 |.     ..|| |        . .|     .| | ..  | . |. .. |||.|||    . . .|.|||      . | .|||||||||.|| ..| .
fgeapn.tisvanlgakklapdedli.nvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry....dtnpvvvhcsaGvGrsGtivaisl

GM-RLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
 . ....     ....... ||..|   .|   |  . ..|| ||
vqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 27-267 1e-33 111.6 In-house 36-269 (285) alignment 
Range on Protein: 27-267
Range on HMM: 36-269/285.0
SNLNRYNNILPNPRTRVRLSKlNDDDittYINANYVHGYDGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLfNEREG
 .|||| ..     ||| | .  | |   || |....     . |||.|||| | |  |||.|... .   ..|.  | | | |||| |.|  |  |   
pdlnryadvrcieetrvvlkn.hdrd...yihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl.gevvk

LGDMQAGFVNV--AVLAGVRSNGYIATKlriKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWsDDPERPWIVHCSAGVGRTGTFITIDIG
.|  .  . ..    .||   |    ..     | |     . |     |||.  | ..  .... . |..  .  |.|  |||||||||| ||. ||  
fgkyeitlteckeeaiagtilnaltvin...tedasseplymnhvqvpwwpdqlapedarpmielykwvkkv.npkekpicvhcsagvgrtatfvgidya

MRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
   . |    .. .|.| .|  |   ||   |  | | || ||
tirimenpniemldivremramrfqavqshmqflflyvvlmey
Y_phosphatase Protein-tyrosine phosphatase 28-265 2e-73 242.0 Pfam-A 3-234 (235) alignment 
Range on Protein: 28-265
Range on HMM: 3-234/235.0
NLNRYNNILPNPRTRVRLSKLND-DDittYINANYVHGYDgAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPtvlfNEREG
. |||..|||  .|||.|.. ..  |   |||||||.||.  . ..||||||.. |  |||||||. . ..|||.| |.||||||||.|||    .|.|.
kknRykdilpydktrvklkgsegpsd...YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp....eeeee

LGDMQAGFVNVAVLAGVRSNGYIATKLRIKHDKSDT-ERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDIGM
    .  .|.. .     ...|. .||..|..|... .|.|.......|||||||... ........|...... . | .|||||||||||||...|| .
sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

RLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLS
. |....  .| .|...||| |. |||  || .| ||.. 
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 28-265 2e-73 242.0 In-house 3-234 (235) alignment 
Range on Protein: 28-265
Range on HMM: 3-234/235.0
NLNRYNNILPNPRTRVRLSKLND-DDittYINANYVHGYDgAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPtvlfNEREG
. |||..|||  .|||.|.. ..  |   |||||||.||.  . ..||||||.. |  |||||||. . ..|||.| |.||||||||.|||    .|.|.
kknRykdilpydktrvklkgsegpsd...YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp....eeeee

LGDMQAGFVNVAVLAGVRSNGYIATKLRIKHDKSDT-ERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDIGM
    .  .|.. .     ...|. .||..|..|... .|.|.......|||||||... ........|...... . | .|||||||||||||...|| .
sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

RLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLS
. |....  .| .|...||| |. |||  || .| ||.. 
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_PTPRA_pd Subfamily PTPRA 28-267 2.9e-67 221.9 In-house 60-294 (330) alignment 
Range on Protein: 28-267
Range on HMM: 60-294/330.0
NLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGaHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTvlfNEREGL
. ||. ||||.  .|| ||...  . . |||| ...||     ..||.|||   |  |||||.|| .. .|||.| |.|. .||||.|||.   .     
eknrvvnilPydfsrvilsvkeGveesdyinasfidGyke.kdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd...eGlvty

GDMQAGFVNVAVLAGVRSNGYIATKLRiKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDIGMRL
|...    .. ||  .    .. ..|  .. . ...|.|  . |.|||| |||.|.  ..|.|..|..  .    | .||||||||||||||..|  .  
Gnirvevedetvlvdytvrkflvqqlp.datrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavler

LQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
..  .. .| |...|||. |. |||  || || |||| ||
vkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 28-267 2e-59 196.0 In-house 46-276 (315) alignment 
Range on Protein: 28-267
Range on HMM: 46-276/315.0
NLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGaHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPtvlfnEREGl
. |||.||||  ..||.|  ..|.    |||| |....|    .|||.||| ...  ||||||..... .||||| .||  . ||..|||     .|.. 
kknryknilPldsarvkleviddsPdsdyinasyiksvdd.dkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP.....drka.

GDMQAGFVNVAVLAGVRSNGYIATKLriKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDIGMRL
  .. | ..|..|      . .| ||     ||.. | |  . |. |||.||. .|. ..|....|.   .  | . .||||||||||| .|.||  .  
dsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaq

LQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
....   .| .... ||..|  .||  |.  | | .. |.
ikrtrsvdvfnfvknlrakrpylvqteeeyafiydavled
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 28-266 8.5e-57 187.9 In-house 63-289 (319) alignment 
Range on Protein: 28-266
Range on HMM: 63-289/319.0
NLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGaHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTglqekgREKCARYWPTVLfNEREGL
. ||. |||.  ...|.| .|.  . . |||| .| ||   .  |||.||| . |  |||||.|| |. .||..|      ..||..|||    ...|. 
dknriinilafdknvvklerliGeefsdyinasfvtGyqr.kdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplki.vikeer

GDMQAGFVNVAVLagvrsngYIATKLRIKH-DKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSD--DPERPWIVHCSAGVGRTGTFITIDIG
....   |. .         |.  .... .  |    | .  . |  |||.|||  . ....... ||   .  . ... .|||||||||||..|..|. 
fkvkvdsveetae.......yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvl

MRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSE
.  ..|  . .| ...| ||..|  .||.  |  | |  | |
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 28-266 2.5e-56 186.3 In-house 27-253 (284) alignment 
Range on Protein: 28-266
Range on HMM: 27-253/284.0
NLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGaHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTglqekgREKCARYWPTVLfNEREGL
. ||. .||.  ...|.| .|   . . |||| .. ||   .  ||||||| . |  |||||.|| |. .||..|      ..||..|||    ...|. 
dknrighilafdknvvklerliGeefsdyinasfitGyqr.kdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplki.vikeer

GDMQAGFVNVAVLagvrsngYIATKLRIKH-DKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDD--PERPWIVHCSAGVGRTGTFITIDIG
....   |. .         |.  .... .  |    | .  . |  |||.|||  . ....... ||  ..    ... .|||||||||||..|..|. 
fkvkvdsveesee.......yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvl

MRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSE
.  ..|  . .| ...| ||..|  .||.  |  | |  | |
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 28-266 7.5e-52 171.2 In-house 51-277 (315) alignment 
Range on Protein: 28-266
Range on HMM: 51-277/315.0
NLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGaHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVlfneregl
. ||| ||..  ..||.|  |. |. . |.|||.. ||.  .  |||.||| ...  ||||.|.| .   |||.|.| |. ..|. .|||          
qknryiniiaydksrvqlpllendphsdyvnanfidGynk.krryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk........

gDMQAGFVNVAVLAGVRSNGYIATKLRIKhdKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDIGMRL
 ..  | . |.       . |    | .     |  | |. . . |||| |||  | ..... . |. . ..   . .|||||||||||||||.|  .  
.kviyGkitvtrkseevnteytvrtlsvv..fgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldq

LQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSE
..     .| ..|...|. |  |||  || .| |..| |
aeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 28-261 1e-49 163.8 In-house 9-233 (239) alignment 
Range on Protein: 28-261
Range on HMM: 9-233/239.0
NLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLfnerEGL
  ||| ||.   ..|| | ||..|  . ||||.|.. |||.  .||||||   ... |||||.|.     |||.||| |  ..|| .|||          
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst....sky

GDMQAGFVNVAVLAgvrsnGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDIGMRL
 ...  . .  |.|      ||   . . .     || | .| |  |||.|||  .  |. . . . . |    |||..||||||||||.|. ||  .| 
cnlrvtlrktevfa.....dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

LQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAY
 ...   .. . .. .|.||  |||  ||  | .
akkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 28-261 1.1e-49 163.8 In-house 10-234 (239) alignment 
Range on Protein: 28-261
Range on HMM: 10-234/239.0
NLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLfnerEGL
  ||| ||.   ..|| | ||..|  . ||||.|.. |||.  .||||||   ... |||||.|.     |||.||| |  ..|| .|||          
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst....sky

GDMQAGFVNVAVLAgvrsnGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDIGMRL
 ...  . .  |.|      ||   . . .     || | .| |  |||.|||  .  |. . . . . |    |||..||||||||||.|. ||  .| 
cnlrvtlrktevfa.....dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

LQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAY
 ...   .. . .. .|.||  |||  ||  | .
akkqktvdifnyvkairedrphmvqtseqyvfih
0041856 (Phosphotyrosine protein) phosphatases II 28-266 6.1e-47 154.9 In-house 3-169 (182) alignment 
Range on Protein: 28-266
Range on HMM: 3-169/182.0
NLNRYNNILPNPRTRvrlsklndddITTYINANYVHGYDGAHGtYIATQGPTPTTTPDFWRMVWETNANSIVMVTglqekgrekCARYWPtvlfneregl
..||| .|||....|            .|||||.. |.  |   .||||||.. |..||.||..| . ..||..|         . .|||          
dknrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

gdmqagfvnvavlagvrsngyiatklrikhdkSDTERIVMHYWFNSWPDHGVPSeTGNVVKMLQAVREwsddPERPWIVHCSAGVGRTGTFITIDIGMRL
                                .. || ...|.. .|||||||. .  .......|.|    ...| .||||||||||||.. ... ..|
................................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl

lqergRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSE
     .... |... .|. |. ||..|.|  | . .| |
.....gvsleeavklvrsrRpgmvitpnqyfflqlalle
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 28-264 9.7e-45 147.6 In-house 47-232 (392) alignment 
Range on Protein: 28-264
Range on HMM: 47-232/392.0
NLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGaHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGrekcarywptvlfneregl
. |||.||||  ..||.|  ..|   . |.|| |....|  . .|||.||| ...  ||||||.. |. .|.||| |.|                     
kknryknilpydsarvkleviddipdsdylnasyipsfdn.ekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...................

gdmqagfvnvavlagvrsngyiatklrikhdKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDIGMRL
                               | |  | |  . |  |||..||  | ...|... |.    .  .| |.||||||||||  |.||  .  
...............................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvah

LQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVL
 ..    .| ...  .|. |  |||  ||  | |  .
akktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
subfamily_ptpA1_pd Subfamily ptpA1 28-229 1.7e-41 137.4 In-house 49-257 (418) alignment 
Range on Protein: 28-229
Range on HMM: 49-257/418.0
NLNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDgaHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLFNERE--
. ||| ||||  .|||.| |..| . . ||||||. |       .|.|||| | |  ||||||||  .  |||..   |. | || ||||  .  |.   
sknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay..pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsi

-GLGDMQAGFVNVAVLAGVRSN--GYIATKLRIKHDksDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVRE------WSDDPERPWIVHCSAGVGRTG
 | |.   |  .| ..  ..      |. ..|.  .     | . .| .. |||| .|  |  . ..|... .       | | . | ||||||||||||
ygngnevfgtysvelveviqdpereiitrnirltfe..getrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtg

TFITIDIGMRLLQ
|| |  | |. |.
tfctavimmkkld
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 28-266 1.1e-34 114.5 In-house 45-274 (312) alignment 
Range on Protein: 28-266
Range on HMM: 45-274/312.0
NLNRYNNILPNPRTRVRLSklndDDITTYINANYVHGYDgAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTV-LFNEREG
.|||| ||    | |  |.     |   || ||.|.        ...||||   |.  ||...    . ||....|. | | ||||.|   .  | . | 
dlnrypniqcwdrgrftla....gdenfyihanfvkict.kperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

LGDMQAGFVnvAVLAGVRSNGYIATK-LRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREwsdDpERPWIVHCSAGVGRTGTFITIDIGM
            .  | .|.  |. . |..    .  |  . || . ||||||.|       ..| ||.    |  .| | |||||||||||.. |.  .
hrvyteyct..eieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk...d.kkpviahcsagvgrtgtlaliesmi

RLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSE
  |.   . || ..   |||||.  |.   |  .| ... |
aalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvle
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 28-256 5.9e-33 108.9 In-house 52-269 (301) alignment 
Range on Protein: 28-256
Range on HMM: 52-269/301.0
NLNRYNNILPNPRTRVRLsklNDDDITTYINANYVHGYdGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLFnEREGL
. .||...  .| | |..    .|     | ||..    |    .|||||| . |. ||| |.   . . |||..   ||  |||. | |.    |.  .
dkhryptvPckPstavev...ivdGkrvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis.ekldi

GDMQAGFVNVAVLagvRSNGYIATKLRIKHDKSD-TERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREwsddPERPWIVHCSAGVGRTGTFITIDIGMR
|  .   .|  ..    ..  .  .|...    . . | |.|| ...|.|.|||    .. .... |..     |.| .||||||.||. .||. ..  |
grfkikiknkeli...lnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigteylar

LLQERGRCNVNEIIRRLRKDRCAMVQHPEQ
 ..   . ...| ...||..|   ||. .|
eveadptieltealkhlrehrwngvqtnsq
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 28-267 1.3e-32 107.6 In-house 57-288 (305) alignment 
Range on Protein: 28-267
Range on HMM: 57-288/305.0
NLNRYNNILPNPRTRVRLSKlndDDITTYINANYVHGYDGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLFNEREgl
  |||...  . .. |.|.|      . || ||||      .  .|..|||   |  .|| || . . . |||.    | |. |||.|||.   . .|  
tknryqdvpcqdqsavkldk...pspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle..

gdMQAGFV--NVAVLAGV-RSNGYIATKLRIKHDKsDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREwsddPERPWIVHCSAGVGRTGTFITIDIG
  ...| |  ||.    . | .    | |.. .   | .  | |  .. ||| |||      ...| |.|      . | .||||||.||||| ..|.  
..lksgivvenvsgskpmerdaeiqitllnltysg.dqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtivaieyi

MRLLQERGRCN-VNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
.  . |  .|  . |... || .|.  .|   |  | ..|. .|
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 29-267 4.2e-59 195.0 In-house 46-275 (515) alignment 
Range on Protein: 29-267
Range on HMM: 46-275/515.0
LNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGaHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLFNereglg
 |||.||||  ..||.|  .||.    |.|| |....|    .|||.||| .... ||||.|.. |   |.||| |.|  . ||..||| .  .      
knryknilPydsvrvklevindnPhsdyfnasyipsfdn.dkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgd......

DMQAGFVNVAVLAGVRSNGYIATKLRIKhdKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDIGMRLL
 .. | ..| ...     | |  ||..   |.|  | |  . |. |||.||| .|  ..|....|.   .  . | |.|||||||||| .|.||  .   
svkfGsikvelvsleactggikrkltvl..kgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvaha

QERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
..    .| .... .|..|  .||  ||  | | .. |.
kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavled
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 29-263 1.7e-47 156.6 In-house 6-234 (237) alignment 
Range on Protein: 29-263
Range on HMM: 6-234/237.0
LNRYNNILPNPRTRVRLSKLNDDdiTTYINANYVHGYDGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVlfNEREGLG
 ||| ||     .|| |     .  . ||||.|..|.||.  .|||.|||  ..  |||.|||. .   |||.||| |. ..|| .|||    .. .  |
knrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst..dqpaayg

DMQAGFVNVAVLAGVRSNGYIATKlrikHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDD--PERPWIVHCSAGVGRTGTFITIDIGMR
 .   .     ..      .. .|    . .    |..  | | ||||.||| .|  .... . . . |       |||.|||||||||| |. ||  .|
vltvslkkkeefsdytvrslllsk....rltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlr

LLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKV
  .|.   .. . .  . .||  ..|  .|  | ...
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqt
subfamily_CG7180_pd Subfamily CG7180 29-267 6.5e-45 148.0 In-house 45-289 (296) alignment 
Range on Protein: 29-267
Range on HMM: 45-289/296.0
LNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGaHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGReKCARYWPTVLfneREGLG
 ||. ...|   .|| |.||. .. . |||| || ..   .  || |..|.  |  .|||.|.. .....|..|   .  . ..  |||      .|  |
knrdvkvvPyDynRvvLekldGeeksdYinavyvdsflk.kkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks...keqyg

DMQAGFVNVAVLAGVRSNGYIATKL-----RIKHDKSDTERIVMHYWFNSWPD-HGVPSETGNVVKMLQAVREWSDDP-----ERPWIVHCSAGVGRTGT
..    |..  .| ...  .  ||        ... .  .|||... .  |.  . ||. |  ...... || | .       | | .|..| |..|.| 
eifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGv

FITIDIGMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
...||. . |... .. .| | ...||..|  .|.  |.  . | ||.|.
ylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 29-256 2.3e-44 146.2 In-house 59-271 (290) alignment 
Range on Protein: 29-256
Range on HMM: 59-271/290.0
LNRYNNILPNPRTRVRLSKLNDDDittYINANYVHGydgAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPtvlfnEREGLG
 ||| ..  | .||| |.   | |   |. ||||.|    . ..| |||..  |. |.|||| ....  |||.  | |.|. ||..|.|     |.||  
knrykdvvcndktrvilkdGydGd...yvhanyvkG...lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyyp.....ekeGev

dMQAGFVNVA-VLAGVRSNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDdperPWIVHCSAGVGRTGTFITIDIGMRL
 .  | . |   .   . .  |   | ... .|  | .. |.   ||||. |.  |  ....|...|. |     | .||||||.||||||..|..|...
.ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasG....pvvvhcsaGiGrtGtfvaievglqi

LQERGRCNVNEIIRRLRKDRCAMVQHPEQ
| .    .. ...| ||. | . ||   |
lldGkeldlldlvralrnsrlnsvqvdiq
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 29-264 3.3e-43 142.8 In-house 51-275 (439) alignment 
Range on Protein: 29-264
Range on HMM: 51-275/439.0
LNRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGaHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGRekcarYWPTvlfNEREGLG
 |||... .   ||| | ..     . ||||||..||      |||||||.  || ||||.|.| ..  |||.| | |  .     |||.   ..    |
knrykdvgafdhtrvtlqeipgvphshyinanyikGyyd.dklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywps...daevcyg

DMqagfvNVAVLAGVRSNGYIAT--KLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPER-PWIVHCSAGVGRTGTFITIDIGM
|.      | |   .    |.    |.  ..|... || |... . .|||. ||...  |...|.|.    |. |  | .|||||||||||| |..|| .
di.....avrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdial

RLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVL
  |.   . ... |.. |||.|  |||.  |  | |. .
eqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 29-266 7.1e-34 112.1 In-house 50-342 (350) alignment 
Range on Protein: 29-266
Range on HMM: 50-342/350.0
LNRYNNILPNPRTRVRLSKL--------NDDDITTYINANYVHGY----DGAHGT-YIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARY
 |||.||||  ..||.| |                ||||||..      .   .  |||||.|.| |  ||.... . . . |...| ..| ..||| ||
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

WPTVLFNE--------REGLGDMQAGFVNVAVLAGVRS-NGYIATKLRIKHDKSDTE--------RIVMHYWFNSWPDHGVPSETGNVVKMLQ-------
|.   ...        .|  ....     .| . .  | |  |. .  .|. .| |.         .|..  .. |.| ..  .  .....|.       
WqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevkndlid

---AVREWSDDPERPWIVHCSAGVGRTGTFITIDIGMR------LLQERGR---------CNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSE
   |     ..   | .||||||||||||..|.|  .        |... |           .. |. .||| |  |||  .|  | |. |  
dlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 29-267 3.3e-33 110.0 In-house 46-270 (288) alignment 
Range on Protein: 29-267
Range on HMM: 46-270/288.0
LNRYNNILPNPRTRVRLSklndDDITTYINANYVHgYDGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLfNEREGLG
 .||.|.     |||.||    ||   ||.|| |      .   | .| |  .|   .|.|. |.. . |||.. | |||.|| | |.|..|  |.  .|
rdryenlprcditrvkls....ddpdfyiaanvvs.sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl.Gekarig

DMqAGFVNVAVlAGVrsNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVrewsDDPERPWIVHCSAGVGRTGTFITIDIGMRLL
 .    | .   |..  .  .   |   . . ... || .  .. |.|.||| .    ...|. .     . ..| .||.|||||||||.| | | .. |
rl.ctvvkkkr.adi..dklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialesl

QERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
.      ..... .||..|   .|   |  ...... |.
rlddflgirsllaklreerfkaiqtemqylyvhrcvlee
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 29-267 2e-30 100.6 In-house 51-286 (305) alignment 
Range on Protein: 29-267
Range on HMM: 51-286/305.0
LNRYNNILPNPRTRVRLsklNDDDITTYINANYVHGYDGAHgTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVL-----FNE
 ||| ..    . ||.|   .      || ||||     ..  .| || |   |  ||| | .. . ..| |.  |.||| .||. |...       |.|
knrykdvgcldnnrvkl...egpwpheyihanyvstptnpk.rfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee

REGlgDMQAGFVNVaVLAGVRSN---GYIATKLRIKHDKSDTeRIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWsddpERPWIVHCSAGVGRTGTFIT
..    ..  |    |    |..      .|.| |.   ... | | || .. ||| |||.    ....|.  |        | .||||||.||||. . 
kgq..kisvkfess.vtlkfrkdakakvtetvlviegpgeka.rkvthyhwidwpdrgvpaadlailellekarps....kgpivvhcsagigrtgsvvm

IDIGM-RLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
..  . .||. .   . . |....|..|   .|  .|  | ..|. .|
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilny
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 29-266 3.1e-14 47.3 In-house 50-277 (303) alignment 
Range on Protein: 29-266
Range on HMM: 50-277/303.0
LNRYNNILPNPRTRVRLSklnDddiTTYINANYVHgYDgAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEkgrekCARYWPTVLFNEREGLG
 ||. ...    ..|.||   |   ..|| |.|..  | ..   | || | . |. |||.|. | . . ....    |       ..   ..| . . . 
knrfvdvicldhskvkls...d...ssyihasyle.ld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdse.....ydklggdsvfprnqdfl

DMQAGFVNVAVLAGVR-SNGYIATKLRIKHDKSDTERIVMHYwfNSWPDHGVPSE-TGNVVKMLQA----VREWSDdpERPWIVHCSAGVGRTGTFITID
...  .. |  .  |  ..|.    | .   .  .   | ||  ..||   .||. . ..|| .      .| .||   .| .    .|.||.|||  ..
kfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhy..kawphnsipsdgspkfvkqiwqlqsvlrkysd..stptvymslsgcgragtfalfe

I-GMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSE
   . | .|.   ..   .  .|. |   ||   |  . | .|.|
tahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllae
subfamily_eak_pd Subfamily eak 29-181 1.9e-11 37.9 In-house 53-196 (332) alignment 
Range on Protein: 29-181
Range on HMM: 53-196/332.0
LNR-YNNILPNPRTRVRLSKLNDDdITTYINANYVhGYDGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTvlfNEREgl
.||   .|.|. |  |||.    .    ||||  .  .      || |  .  .  . ||.|| | .. .||..    |.. ||  .|.|    . ||  
vnrnvvkivpydrylvrltssqln.rlGyinasla.efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpd...ktre..

gDMQAGFVNVAVLAGVRSNGYIATKLRIKHdKSDTERiVMHYWFNSWPDHGVPS
  .. |...|     |. | .   .| ..    .| | |.|| .  | .  .| 
.elkfGildverkefvkrniletrllelsk.Gnethr.vlhykvfGwtettlpk
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 29-112 3.2e-06 20.9 In-house 37-118 (332) alignment 
Range on Protein: 29-112
Range on HMM: 37-118/332.0
LNRYNNILPNPRTRVRLSKlnDDDITTYINANYVHGYDgAHGTYIATQGPTPTTT-PDFWRMVWETNANSIVMVTGLQEKGREKC
.||   .    ..|| |.   .|    . ||..| ||   . .|| .| |    |   ||||| | . . |...  ..|| . |.
mnriphlycfdhsrvelap..qdgkddfynaswvdgys.kksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Ptp69D_pd Subfamily Ptp69D 30-267 1.2e-60 200.2 In-house 52-285 (307) alignment 
Range on Protein: 30-267
Range on HMM: 52-285/307.0
NRYNNILPNPRTRVRLSKLNDDDITTYINANYVHGYDGAhGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVlfnereglGD
|||..| .  .|||.|.|.| .. ..||||....||.    ..|| |.|  .|  |||||..| . . |||.. |.|| |.|||.|||            
nRyedikafDktRvkLkkingkedsdYinasfikgykek.kkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie........de

MQAGFVNVAVLAGVRSNGYIATKLRIKHDK-----SDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDIG
.| | ..| .    . . ||  .| . . |      . .| |. | ...|.|  ||  .  ..|... |||     . | .|||||||||.|.|...|. 
vqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsl

MRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
.  |..  . .. |... ||..|  .||  || .| |. | .|
lqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 30-257 6.1e-30 98.8 In-house 56-279 (310) alignment 
Range on Protein: 30-257
Range on HMM: 56-279/310.0
NRYNNILPNPRTRVRLsKLNDDDITTYINANYVHGyDGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLFNEREGLGD
||| ...    .||.| |..      || ||||.  .    |.| .|||   |  |||||...  |.||...    |.|| ||  |||..   |  |   
nrysdvvcldtsrvkl.kidksryedyihanyvkt.nylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcir

---MQAGFVNVAvlAGVRSNGYIATKLRIKHDKSDTE--RIVMHYWFNsWPDHGVPSETGNVVK--MLQAVRewsddpERPWIVHCSAGVGRTGTFITID
   .     .        .  ..  .. .  . .. .  |. .  | | ||| ||| |    |   .|  ||        | .||||||..|... ....
vtnlsesseefe..icnlavtfvpdnvpvdeqpanlkelrvslikwpn.wpdrgvpdekchtvpqrllaqvr......hgpcvvhcsagkdrlyvvvalk

IGMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQA
. .  |..  . ...|..  |.|.|   .| . | 
lkidkldrglkvdaeevktellksraiciqtelqy
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 30-146 2e-12 41.1 In-house 52-181 (349) alignment 
Range on Protein: 30-146
Range on HMM: 52-181/349.0
NRYNNILPNPRTRVRLSKLND--------------DDITTYINANYVHGYD-GAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCAR
|||..|||   .||.| |                   .  ||||||..     ..  ||||| | |.|  ||....   . . .. ..  .|.. ||| .
nrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdi

YWPTVLFNEREglGDMQAGFVNVAVLAGVRSN
||    ... .    .|  . ..| . |  ..
ywqelsysnit..vklqnsslyianvqGnslr
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 30-188 2.5e-08 27.0 In-house 31-163 (169) alignment 
Range on Protein: 30-188
Range on HMM: 31-163/169.0
NRYNNILPNPRTRVRLSKLNDDDITTYINAnyvhgydgahgtyiatqgptptttpdfwRMVWETNANSIVMVTGLQEKGR---EK-CARYWPTVLFNERE
||    |   .|||.| .. .|  . ||||                            ||.|||||  ||.. . ..|     ||   .  |.|.. |  
nrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlgdtddknnfwpekedyqlhpavilgewy

GlGDMQAGFVNVAVL-AGVrsNGYIATKLRIK-HDKSDTERIVMhYWFNSWPDHGVPSETGNVVK
    .      | .. .||  .| .   . |. .|.. ||.. . . ...||. |||    .| .
t.dslyvrtdkvhantsgv..eglfevsmvihsydddvteklsl.lhystwpqngvpqspvhvgh
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 30-186 8.3e-08 25.2 In-house 30-160 (169) alignment 
Range on Protein: 30-186
Range on HMM: 30-160/169.0
NRYNNILPNPRTRVRLSKLNDDDITTYINAnyvhgydgahgtyiatqgptptttpdfwRMVWETNANSIVMVTGLQEKGR---EKC-ARYWPTVLFNERE
||    |   .|||.| .. .|  . ||||                            ||.|||||  ||.. . ..|     ||   .  |.|.. |  
nrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlGdtddknnfwpekedyqlhpavilGewy

GlgDmqAGFVNVAVLA--GVRSNGYIATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNV
   |  . .|    .       .| .   | |.. ..|  . .  . ...||. |||    .|
t..d..slyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhv
0044763 (Phosphotyrosine protein) phosphatases II 37-264 1.1e-34 115.0 In-house 1-167 (178) alignment 
Range on Protein: 37-264
Range on HMM: 1-167/178.0
PNPRTRVRLSKLNDDDITTYINANYVHGYdgahgTYIATQGPtptttPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLFnereglgdmqagfvn
| .|||| ||.| .   . ||||... ..      |.....|     .|......| . ..||..|. .| |..|| .|||.                  
pldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

vavlagvrsngyiatklrikhdksdterivMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDIGMRLlqergRCNV
                              ..| .  .||||||. .  . .......|. |....| .|||||||||.||.. ... ..|     ....
..............................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsl

NEIIRRLRKDRCaMVQHPEQAEFAYKVL
.|.|...|. |. .|..|.| .. |.. 
eeaielvrerRp.ivpnpgqlrqLyefe
subfamily_egg_pd Subfamily egg 40-264 2e-22 74.3 In-house 54-266 (307) alignment 
Range on Protein: 40-264
Range on HMM: 54-266/307.0
RTRVRLSKLNDDDITTYINANYVHGYdGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKgrEKCARYWPTVLFNEREG-LGDMQAGFVNVA
 .||.|   .   .  .| ||.|.|      ..| .| |   |  ||||||.. . . |||.|  .|   |.|  |||    .      | ..   ..| 
ssrvklelrrGqylddfihanrvkGk.pllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvd

VLAgvrSNGYIATKLRIkHDKSDTERIVMHyWFNSWpdhGVPSETGNVVKMLQAVREWSddpeRPWIVHCSAGVGRTGTFITIDIGMRLLQeRG---RCN
  |      .  |||..     | || . | |   .      |.    ...|. .|. |    .| .|..  || ...|...|.| .  |  ||   .  
ska...dplfrvtklkl.vGgddeerfleh.wqgdv...nnssdvysplrvlrklrnls....kpvvvqdilGvskaatlvaieiallsll.rGpitksl

VNEIIRRLRKDRCAMVQHPEQAEFAYKVL
| . .  ||. |   |. . .  | |...
vlravvflrlrrrlsvesvllylfvyrlv
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 40-261 3.4e-22 73.9 In-house 32-252 (290) alignment 
Range on Protein: 40-261
Range on HMM: 32-252/290.0
RTRVRLSKLNDDDITTYINANYVHGYDGAhgTYIATQGPTPTT-------TPDFWRMVWETNANSIVMVTGLQEKGRE----KCARYWPTVLfnereGlG
 ||| |          || ||.|   .|     |.|| |   .         .|| |. . .....||.   .|| ..     ||.| |.       | .
atrvvLkgygkrfnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesv.....g.e

DMQAGFVNVAVLAGVRSNGYIATKLRIKHDKSdTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVRewsdDPERPWIVHCSAGVGRTGTFITIDIGMRLL
... . ..|     .  .. .  .| .|.|.   |  | |.....| .  |. .|  .....| |.      . | ||||  |. |  .. .|..|. ..
elkfkgltvkCkskekeddvetRelvvkfdde.eeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgyQki

Q-ERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAY
   .|  ......  ||| |  .......  |. 
aetsgsvkledvlkalrkqralaitsalelafvd
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 41-101 7.5e-10 32.8 In-house 52-116 (347) alignment 
Range on Protein: 41-101
Range on HMM: 52-116/347.0
TRVRLSK-----LNDDDITTYINANYVHgYDGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMV
||| ||       . ||. ||||| ... .| |.  || || | | |  |||.||  |.   .| .
trvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
0046846 (Phosphotyrosine protein) phosphatases II 46-266 8.1e-43 141.5 In-house 4-171 (176) alignment 
Range on Protein: 46-266
Range on HMM: 4-171/176.0
SKLNDDDITTYINANYVHGYdgahgTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTvlfNEREGLgdmqagfvnvavlagvrs
 .| .|   .|||||.. |.      .||||||.| |..||..|..| . . .|..| ..|.|| ||..|||     |..|.                  
rllgldldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi..................

ngyiatklrikhdksdterivmHYWFNSWPDHGVPSEtGNVVKMLQAVREWSDDPeRPWIVHCSAGVGRTGTFITIDigmrLLQERGRCNVNEIIRRLRK
                      .|..  |||||||.    . ..|...||. ..  .| .||||||.|||||.. ..    ||. .   .|.|.....|.
......................qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvre

DRC-AMVQHPEQAEFAYKVLSE
 |.  .||.||| .| |... .
qRplgavqtpeQyrflyefell
0043147 (Phosphotyrosine protein) phosphatases II 52-261 7.2e-41 135.1 In-house 3-154 (172) alignment 
Range on Protein: 52-261
Range on HMM: 3-154/172.0
DITTYINANYVHGYDGAHGtYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLqekgrekcarywptvlfnereglgdmqagfvnvavlagvrsngyiat
. ..||||.|...|   .  .||||||.. |..|||||..| . . ||..|.|                                               
egsdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel...............................................

klriKHDKSDTERIVMHYWFNSWPDHGVPsETGNVVKMLQAVRE-WSDDPERPWIVHCSAGVGRTGTFITIDIGMrllqerGRCNVNEIIRRLRKDRCAM
     .|... || ...|.. .|||||||  .  . ..|. ..|    .|. | .||||||||||||.. ... .       .... |... .|. |. .
....lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpga

VQHPEQAEFAY
||.|.|  | |
vqnpsqyrfly
0051429 (Phosphotyrosine protein) phosphatases II 53-267 1.3e-49 164.5 In-house 3-224 (272) alignment 
Range on Protein: 53-267
Range on HMM: 3-224/272.0
ITTYINANYVHGYdGA---HGTYIATQGPTPTTTPDFWRMvWETNANSIVMVTGLQEKGREKCARYWP----TVLFNEREGLGDMQAGFVNVAVLAGVRS
...||||..| || |     |......||.| |  ||||. .| . ..||..... |.||.|| ||||     .|  . ..  ..  |.. | .|  .  
lsgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

NGYIATKLRIKHD-KSDTERIVMHYWFNSWPDHGVPSETgnVVKMLQAVREwsddpERPWIVHCSAGVGRTGTFITIDIGMRLLQERGRCN--------V
. || ..|....  . .. | |||... .|||||||.|.  ....|.....     ..| .||||||..||||.. ... .. . .   ..        .
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

NEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
 |....||. | ..||..|| .| |..| |.
eeaveelraqrpgavqteeqylflyeallel
0051082 (Phosphotyrosine protein) phosphatases II 53-264 3.3e-35 116.2 In-house 2-149 (151) alignment 
Range on Protein: 53-264
Range on HMM: 2-149/151.0
ITTYINANYVHGYdgahgtYIATQGPtpttTPDFWRMVWETNANSIVMVTGLQEKGreKCARYWPTVLfnereglgdmqagfvnvavlagvrsngyiatk
...|||..|| |.      .....||    ..||.....| . ..||......| |  .|..|.|                                   
lsdyinfsyvtgg......lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg................................

lrikhdksdteRIVMHYWFNSWPDHGVPSETGNVVKMLQAVREwsdDPERPWIVHCSAGVGRTGTFITIDIGMrlLQergrCNVNEIIRRLRKDRCAMVQ
           . |.|... .|||.|.|  .  |...|.....   ... | .||||||.|||||.. ... .  |.    ....|... .|. |. .||
...........ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylml..lg....vsleealeeyrlkrpgvvq

HPEQAEFAYKVL
...|  | ...|
pnqqflfqlfal
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 54-118 4e-07 24.4 In-house 13-71 (130) alignment 
Range on Protein: 54-118
Range on HMM: 13-71/130.0
TTYINANYVhGYDGAHGTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKgrekcARYWPT
 |||||..| |  |    |. || |   |. |||.|. |   | .|..  ..|.       ||| 
ntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpd
0036282 (Phosphotyrosine protein) phosphatases II 55-262 3.9e-43 142.5 In-house 3-164 (174) alignment 
Range on Protein: 55-262
Range on HMM: 3-164/174.0
TYINANYVHGYDGAHgTYIATQGPTPtttpdFWRMVWETNANSIVMVTGLQEKGREKCARYWPTvlfnereglgdmqagfvnvavlagvrsngyiatklr
.||||......      .||.|||..     ||.|..| . ...||.. ..|.|..|| .|||.                                    
dyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

ikhDKSDTERIVMHYWFNSWPDHGVPSETGnVVKMLQAVREWSDD-PERPWIVHCSAGVGRTGTFITIDIGMRLLQeRGRCNVNEIIRRLRKDRCAMVQH
   ...| || ...|..  |||||||. .  . .....|.|.  . |..| .||||||||||||.. ... .|.|   .  .. ...|.||. |. |||.
...lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt

PEQAEFAYK
|.| .| |.
psQyrflyy
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 56-265 1.8e-16 54.5 In-house 77-282 (302) alignment 
Range on Protein: 56-265
Range on HMM: 77-282/302.0
YINANYVHGYDGAhGTYIATQGPTPTTT---PDFWRMVWETNANSIVMVTGLQEKGReKCARYWPTvlfnEREGLGDMQAGFVNVAVLAGVRSNGyIATK
|.||  |.  .    . | .| |. ...    .|||||.. .  |.|.. | .|  .     ..|.    . .   .... |||.     .  .   .  
yvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpk....ksgdykeygkmfvNnrkVekaeeek.tryv

LRI-KHDKSDTeRIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDIGMRLLQERGRCNVNEIIRRLRKDRCAMV
. .  .. |..  ... | .. |... || . ....|  . | . . . . . ..    |.|| |.|.|  . .  ||.    |..||.. .|..|...|
iEvlPegcsns.vlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRprav

QHPEQAEFAYKVLS
.  .|  . | .| 
dslkQyvslyiall
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 70-118 3e-07 24.1 In-house 236-281 (440) alignment 
Range on Protein: 70-118
Range on HMM: 236-281/440.0
GTYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKgreKCARYWPT
 ..|||| |  .|  ||||.| . .  .|.|.  |..|    |. ||| 
nafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpv
0049260 (Phosphotyrosine protein) phosphatases II 71-262 1.9e-38 126.9 In-house 10-144 (152) alignment 
Range on Protein: 71-262
Range on HMM: 10-144/152.0
TYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWptvlfnereglgdmqagfvnvavlagvrsngyiatklrikhdksdterivmHYW
 .||||||.| |..|||||..| ... |||.| |.|.|..||..|.                                                   .| 
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...................................................qyl

FNSWPDHGVPSETGNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDIGMrllqerGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYK
.  |||||||. .  .  .|......  |.. | .||||||||||||.. ... .       .... |.....|. |  .|..|.| .| |.
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 71-263 5.4e-29 95.8 In-house 6-199 (199) alignment 
Range on Protein: 71-263
Range on HMM: 6-199/199.0
TYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVlfneREGLGDMQAGFVNVAVLAgvRSNGYIATKLRI--KHDKSDTERIVMH
 ||||| |   |  |||.||||| .  ||||   | .     . ||||.      | | . .  | . ...      |  | | .  .     . | . |
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywptt....esgtgkygslsvttktit..tkpdytitaliltnnttappstreish

YWFNSWPDHGVPSET---GNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDIGMRLLQERGRCN--VNEIIRRLRKDRCAMVQHPEQAEFAYKV
| | || ..  |  .   | ||   .  . . .. . | ||||| | | || |...|||.|  .|       . |. .|||. || ..   .. .| |.|
yqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 71-263 5.4e-29 95.8 In-house 5-198 (198) alignment 
Range on Protein: 71-263
Range on HMM: 5-198/198.0
TYIATQGPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVlfneREGLGDMQAGFVNVAVLAgvRSNGYIATKLRI--KHDKSDTERIVMH
 ||||| |   |  |||.||||| .  ||||   | .     . ||||.      | | . .  | . ...      |  | | .  .     . | . |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywptt....esgtgkygslsvttktit..tkpdytitaliltnnttappstreish

YWFNSWPDHGVPSET---GNVVKMLQAVREWSDDPERPWIVHCSAGVGRTGTFITIDIGMRLLQERGRCN--VNEIIRRLRKDRCAMVQHPEQAEFAYKV
| | || ..  |  .   | ||   .  . . .. . | ||||| | | || |...|||.|  .|       . |. .|||. || ..   .. .| |.|
yqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 77-257 1.9e-20 67.5 In-house 98-277 (302) alignment 
Range on Protein: 77-257
Range on HMM: 98-277/302.0
GPTPTTTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLFNE-REGLGDMQAGFVNVAVLAGVRSNGYIATKLRIKHDKS--DTERIVMHYWFNS
 |   |.  .| .. . |   .| .... |.. .||| |. . . .| . |   ...  |.  .      ...   .. || .|   .... |    | .
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDHGVPSETGNVVKMLQAVREWsddpERPWIVHCSAGVGRTGTFITIDIGMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQA
||||| | |. . ...|.    .     .  .||||||||||||...|  |. | ...  ... .|.  .|. |   ||. .| 
wpdhGapkeaytaldilkfcesy....kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 82-262 3.1e-20 67.3 In-house 40-215 (255) alignment 
Range on Protein: 82-262
Range on HMM: 40-215/255.0
TTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLfNEREGLGDMQAGFVNvavlagvRSNGYIATKLRIKHDKS--DTERIVMHYWFNSWPDHGV
|   |....  |... .||.. ..|.|.||| .|.|. . .|.  | |..    .        |.  .   |.|    .     . | || .. |...  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplek.deklkladvnvtttk.......ssadvvlrtleitstlgekkkthtvkhysykGWiekna

PSETGNVVKMLQAVREwSddpeRPWIVHCSAGVGRTGTFITIDIGMR----LLQE--RGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYK
| .. .. ..|..||. |    .. .||||.|.||. .|. ...  .     |..   .  .  .... ||. | . .. | |  |.  
Pelareilnilkvvrd.s....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsil
subfamily_hpo-7_pd Subfamily hpo-7 82-262 2e-17 57.9 In-house 46-221 (263) alignment 
Range on Protein: 82-262
Range on HMM: 46-221/263.0
TTPDFWRMVWETNANSIVMVTGLQEKGREKCARYWPTVLfNEREGLGDMQAGFVNVAVLAGVRSNgYIATKLriKHdKSDTERiVMHYWFNSWPDHGVPS
| . |....  |... .||..  .|.|.||| .|.|. . .|.  | ...    .|     ....  .   |  .. |  |.  | || .. |...  | 
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlek.dekqklanvnvcttkvqsdvllktl.ellstl..ge.Kkktht.vkhysykgWiekndpe

ETGNVVKMLQAVREWsddpeRPWIVHCSAGVGRTGTFITIDIGMR----LLQE--RGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYK
.. .....|...|.      .. .||||.|.||.  |  ...  .     |..   .  .  .... ||. | . .. | |  |.  
lareilnilkvarns.....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsil
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 139-264 5.1e-20 66.2 In-house 68-190 (440) alignment 
Range on Protein: 139-264
Range on HMM: 68-190/440.0
VLAGVRSNGYIATKLrIKHDKSdteRIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDD-PERPWIVHCSAGVGRTGTFITIDIGMRLLQERGRCNVN
 . || .. || .   |.  .|   | . .| ...|||.|||  .| |.||.| | |  .   . | .||||||.||||  |..|  .|  .   . .. 
evkgvpdsdyinasy.ingies...rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidif

EIIRRLRKDRCAMVQHPEQAEFAYKVL
 .|  .|..|  ||| |||  | ....
sfinsmrnnrpqmvqtpeqyafvheav
0048076 (Phosphotyrosine protein) phosphatases II 149-265 9.1e-25 82.4 In-house 30-140 (145) alignment 
Range on Protein: 149-265
Range on HMM: 30-140/145.0
IATKLRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPeRPWIVHCSAGVGRTGTFITIDIGMRllqeRGrCNVNEIIRRLRKDRC
| | |.. ..... || ...|.. .|||||||. .  . ..|....|. ... .| .||||||||||||.. ... ..    .| ... |.....|. | 
ittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrp

AMVQHPEQAEFAYKVLS
 .|..|.| .| |... 
gavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 153-262 5.8e-24 79.9 In-house 36-139 (144) alignment 
Range on Protein: 153-262
Range on HMM: 36-139/144.0
LRIKHDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDdPERPWIVHCSAGVGRTGTFITIDigmrLLQERGrCNVNEIIRRLRKDRCAMVQ
|. .... . || ...|.. .|||||||. .  . ..|....|. . ...| .||||||||||||.....    |. ..| ....|.....|. |. .|.
lteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavp

HPEQAEFAYK
.|.| .| ..
npgqlrfLle
subfamily_PTEN_pd Subfamily PTEN 156-258 2.7e-07 25.8 In-house 72-170 (184) alignment 
Range on Protein: 156-258
Range on HMM: 72-170/184.0
KHDKSDTERIVMHYWFNswpDHGVPsETGNVVKMLQAVREW-SDDPERPWIVHCSAGVGRTGTFITIDIGMRLLQERgRCNVNEIIRRLRKDRCAMVQHP
|.|... .  |..| |.   ||  | .   . .... ...| . |...  .||| || ||||. |.  .  .|| |.   .. |.  . |      |. |
kydskkfdgrvavypfd...Dhnpp.plelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllek.aeealelfaeaRtknkkgvtiP

EQAE
 |  
sqrR
0038934 (Phosphotyrosine protein) phosphatases II 157-264 3.1e-13 45.3 In-house 70-173 (194) alignment 
Range on Protein: 157-264
Range on HMM: 70-173/194.0
HDKSDTERIVMHYWFNSWPDHGVPSETGNVVKMLQAVREW-SDDPERPWIVHCSAGVGRTGTFITidigmRLLQERGRCNVNEIIRRLRKDRCAMVQHPE
 |... |.  ..|    .||.|..  . .. . |..| |. ..||.    ||| ||.|||||..      . | .| .....| |...|  |  ......
YdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva.....aYLiyrlgmsaeeAialfrekRpgaipnqd

QAEFAYKVL
. |  .|  
yleallkry
subfamily_PTPDC1_pd Subfamily PTPDC1 165-259 1.6e-07 25.9 In-house 82-167 (182) alignment 
Range on Protein: 165-259
Range on HMM: 82-167/182.0
IVMHYWFnSWPDHGVPSETgNVVKMLQAVREWSDDPerPWIVHCSAGVGRTGTFITIdigmRLLQeRGRCNVNEIIRRLRKDRCAMVQHPEQAEF
 ...| | .|.|.||.| . ... . . |    ..      ||| || ||||  |.      |.    | . .. |. .|. |   .|  || |.
giyvynf.gwkDygvasle.riLdivkvvafalqeg..kvavhChaGlGrtGvliac....ylvy.akrltaekaiklvrskrpksiqtreqvel
PTPc_DSPc_SM00012 166-265 2.8e-33 109.6 In-house 2-104 (105) alignment 
Range on Protein: 166-265
Range on HMM: 2-104/105.0
VMHYWFNSWPDHGVPSETGNVVKMLQAVREWSDDPE--RPWIVHCSAGVGRTGTFITIDIGMRLLQER-GRCNVNEIIRRLRKDRCAMVQHPEQAEFAYK
|.||....|||||||.|. .....|.||...  . |   | .|||||||||||||...|| .. |... .. .. .|...||| |  |||  ||  | |.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VLS
.| 
all
PTEN_1 173-260 9e-10 33.7 In-house 101-185 (196) alignment 
Range on Protein: 173-260
Range on HMM: 101-185/196.0
SWPDHGVPSETgNVVKMLQAVREW-SDDP-ERPWIVHCSAGVGRTGTFItidigMRLLQERGRCNVNEIIRRLRKDR-CAMVQHPEQAEFA
...|||.||    . ...  . || . || ..  .||| ||.||.|| .     . .| ..|. ...| ....|. | ..... |.| .. 
pieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv.....aayLmykgkltadeAlelvrekRppgapnspsqerll
subfamily_VSP_pd Subfamily VSP 176-220 2.2e-06 21.8 In-house 103-147 (212) alignment 
Range on Protein: 176-220
Range on HMM: 103-147/212.0
DHGVPSeTGNVVKMLQAVREWS-DDPERPWIVHCSAGVGRTGTFIT
|| ||.   ..... . |.||  .|...  ..||  | ||||| . 
dhnvpk.leellvftkevkewlekdlknvlaihckGGkgrtGtivc
subfamily_DSP23_pd Subfamily DSP23 179-259 9.3e-06 20.4 In-house 63-137 (148) alignment 
Range on Protein: 179-259
Range on HMM: 63-137/148.0
VPSETGNVVKMLQAVREWSDDPErPWIVHCSAGVGRTGTFITIdigmRLLQERGRCnVNEIIRRLRKDRCAMVQHPEQAEF
 |    .||.... | |  .  |    |||  | |||||...      |..||. .   | |  .|. |   |.  || . 
hppaleqvvefvrvveeaeekne.avsvhcllgrgrtgtmlac....ylvkerkla.aaeaiaevrrlrpgsvetveqekl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 192-265 5e-09 29.9 In-house 256-341 (349) alignment 
Range on Protein: 192-265
Range on HMM: 256-341/349.0
AVREWSDDPERPWIVHCSAGVGRTGTFITIDIGMRLLQERG----R--------CNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLS
|   . .|   . .|||||| ||||...|.|. . .|.       .          .  |.  ||| | .|||   |  . |. | 
arlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealL
subfamily_CDC14_pd Subfamily CDC14 198-257 6.8e-06 20.1 In-house 260-314 (328) alignment 
Range on Protein: 198-257
Range on HMM: 260-314/328.0
DDPERPWIVHCSAGVGRTGTFITIdigmRLLQeRGRCNVNEIIRRLRKDRCAMVQHPEQA
.. |   .||| ||.|||||.|.      |.. . | . .|.|  ||  |  .|  | | 
ekaeGaiavhCkaGLGrtGtLiac....ylmk.hyrftaaeaiawlricrPGsvigpqqk
subfamily_eak_pd Subfamily eak 200-267 3.5e-06 20.6 In-house 235-304 (332) alignment 
Range on Protein: 200-267
Range on HMM: 235-304/332.0
PERPWIVHCSAGVGRTGTFITIDIGMRLLQERGR--CNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
|    |. .. |  |.|.|. ||. .||.... .    |...| . .. |   |    |  | |... .|
psfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldy
subfamily_CG42327_pd Subfamily CG42327 202-267 5.6e-16 53.1 In-house 248-314 (319) alignment 
Range on Protein: 202-267
Range on HMM: 248-314/319.0
RPWIVHCSAGVGRTGTFITIDIGMRLLQER-GRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVLSEY
 | .|||| ||||||. |. || .| |.|     .. ...  .|.||.  |.  || || |||||||
GPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 203-263 4.2e-10 34.0 In-house 230-290 (297) alignment 
Range on Protein: 203-263
Range on HMM: 230-290/297.0
PWIVHCSAGVGRTGTFITIDIGMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKV
. .|||||||||.|  .  |. .  |. .   .|. |.. ||. |  .||  || |. |..
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 205-264 1.4e-08 29.0 In-house 1-60 (69) alignment 
Range on Protein: 205-264
Range on HMM: 1-60/69.0
IVHCSAGVGRTGTFITIDIGMRLLQERGRCNVNEIIRRLRKDRCAMVQHPEQAEFAYKVL
.||||.| |||||||.| . |  ..     .. . .. .|| |  ||   ..  | .  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdal
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 205-255 2.2e-08 28.4 In-house 2-52 (69) alignment 
Range on Protein: 205-255
Range on HMM: 2-52/69.0
IVHCSAGVGRTGTFITIDIGMRLLQERGRCNVNEIIRRLRKDRCAMVQHPE
.||||.| |||||||.| . |  ..     .. . .. .|| |  ||    
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmnei