Gene MbrePTP-sf2-6 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily MbrePTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP044_AA protein Get Run
MbreP044_AA_175-409 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1-234 1.6e-104 343.7 In-house 24-256 (270) alignment 
Range on Protein: 1-234
Range on HMM: 24-256/270.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvrynEAKKV
|||..|||.|.||||||.. |  .|...||||||..|.......||||||||..|...||||.|..|..||||||...|.|| ||.||||.    |.|. 
nRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa....epkek

GDRIYGHISVAVCSGEQHPGYILTHIRLR-KGKEEQLLrHYWFQNWPDHGVPSAEG----AHQVIAMMQNVRAFCEEQRQG-PPIVHCSAGIGRTGTFIA
 .  .|.|.|...| |.. |||||..||. ||.|..|. |.|...|||||||..|.    ..|...|...||....|.... | .||||||.|||||.||
vkledgkikvlalseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.|.|||.||||..||.|.|....||.|  .||||.||||.
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyefl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1-234 9.6e-79 259.3 In-house 32-260 (274) alignment 
Range on Protein: 1-234
Range on HMM: 32-260/274.0
NRYTNILPNPRTRVRLEDEYePWTSVSTYINANYIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPtvrynE--AK
|||..||||...|| || |  .  . |.||||||| ||. . . |.|. ||| ||.. ||||..  ... |||.| . |. . |||.|.|     .    
nryktilPnensrvlleses.sededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP.....daedy

KVGDRiYGHISVAVCSGEQHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEEQ--RQGPPIVHCSAGIGRTGTFIAID
.. .| ||.... | .  .. .| .... |.. ..|. . |||. .|||| .|    |.... ....|.   ||.  . .| .||||||||||| ||||.
eiser.ygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPdd..antlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

QAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 ||| |.|.. || |.||.|.| .||||||  .|||.|
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyeli
subfamily_PTPRD_pd Subfamily PTPRD 1-234 9.5e-77 253.9 In-house 52-273 (564) alignment 
Range on Protein: 1-234
Range on HMM: 52-273/564.0
NRYTNILPNPRTRVRLEDeyEPWTSVSTYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRyNEAkkv
||| ||..  ..||.|.    .... | ||||..| ||  ....|||. ||| .||| ||||||  .|  ||| | . |.|.|||..|||. . .|    
NRyanivaYdhsRVvLsk..vegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tet...

gdriYGHISVAVCSGEQHPGYILTHIRLRKGK--EEQLLRHYWFQNWPDHGVPSAEgaHQVIAMMQNVRAFCeEQRQGPPIVHCSAGIGRTGTFIAIDQA
    ||.. | . . |.   |......|.| |  | .  |.. | .|||||||      ........|||   |. .|| .||||||.|||||||.||  
....ygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesa..tslLdlirkvraln.epdagPivVhCSaGVGRTGtfividam

VRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.. ..| . ||  |.|...||.|  ||| ..|| ||
lerikeektvDiyqyvkalrkqRnamVqteeQYiFi
0050432 (Phosphotyrosine protein) phosphatases II 1-234 2.7e-76 252.2 In-house 72-291 (308) alignment 
Range on Protein: 1-234
Range on HMM: 72-291/308.0
NRYTNILPNPRTRVRLedeyepwTSVSTYINANYIAGYS-SQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNeakk
|||..|||. ..||.|        . |.||||.|. |||  .||..||. |||.||.| ||||||  ... ||| |  .| ||.|||.|||.   .    
NrykdilpydhsRVkl.......degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgg....

vGDRIYGHISVAVCSGEQHPGYILTHIRLRK--GKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCeeqRQGPPIVHCSAGIGRTGTFIAIDQ
 | ..||...| . | |....|......|..  ..|.  ..|... ||||||||.   . ....... || ..   ..|| .||||||.||||||||.| 
.gsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPps..peilldflelvrksl...pggpivVHCsaGvGRtGtfialdl

AVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
....||..|.|| ...|. .|..| |||| |.||.|.
lleqlekeggvdvfeavkklReqRpgmvqtpeqylfl
subfamily_PTPRB_pd Subfamily PTPRB 1-234 3.8e-76 250.9 In-house 55-277 (293) alignment 
Range on Protein: 1-234
Range on HMM: 55-277/293.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSqPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVryneakkV
||||||||   .||.|..  .  .| | ||||||| ||.| |||.||. ||| .|.. ||||||  || .||| | ..|.|.||| .|||.         
nrytnilpydhsrvkLaalkd..esgsDYinanyipgyns.prefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad.......e

GDRIYGHISVAVCSGEQHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVPsaEGAHQVIAMMQNVRAFC-EEQRQGPPIVHCSAGIGRTGTFIAIDQAV
 . .||.|.| . . |.   ... .....|.|||. .|.| |. |||||||  | ..........||    ......| .||||||.||||||||.|. .
epvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvP..ektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrll

RCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
. .||.  || . |||..|..|  .||  .|| ||
qaieeedyvdifgivaelReeRnllvqtekqYifi
0051299 (Phosphotyrosine protein) phosphatases II 1-234 1.4e-74 246.5 In-house 53-278 (288) alignment 
Range on Protein: 1-234
Range on HMM: 53-278/288.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQPReYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryneakkV
|||..|||. ..||.| .. .   . |.||||.|| || .. . .||. |||.||.| ||||||  ... ||| |. .| ||.|||.|||.         
nRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl........g

GDRIYGHISVAVCSGEQHPGYILTHIRLR------KGKEEQLLRHYWFQNWPDHGVPSaeGAHQVIAMMQNVRAFCEeQRQGPPIVHCSAGIGRTGTFIA
|  .||.|.|   | |....|........      ...|..  .|... ||||||||.   . ....... || ... ...|| .||||||.||||||||
gsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd..spellldflrlvrkala.sgggpvvVHCsaGvgRtgtfia

IDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.| ....||..|.|| |..|. .|..| |||| |.||.|.
ldllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfv
0046845 (Phosphotyrosine protein) phosphatases II 1-234 2.1e-74 245.8 In-house 32-266 (284) alignment 
Range on Protein: 1-234
Range on HMM: 32-266/284.0
NRYTNILPNPRTRVRLEDEYEPwTSVSTYINANYIAGYS----SQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVryNE
|||..|||. ..||.|  . .  .. |.||||.|. ||.     .....||. |||.||.| ||||||  ... ||| |. .| ||.|||.|||.   .|
nRykdilpydhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple..ge

AKKVgdriyGHISVAVCSGEQHPGYILTHIRLRK---GKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEE-QRQGPPIVHCSAGIGRTGTF
 ..      |...| . | |....|......|..   ..|.  ..|... .|||||||.   . ....... || ..|.  ..|| .||||||.||||||
vlty.....gdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvpps..pedlleflrlvrellenlpgggpivVHCsaGvgRtGtf

IAIDQAVRCLEETG---EVDCLQIVANMRKHRGGMVQHPQQYEFI
||.| . ..||..|   .|| |..|. .|..| |||| ..||.|.
ialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfv
DSPc_SM00195 1-234 3.5e-72 238.2 In-house 30-254 (263) alignment 
Range on Protein: 1-234
Range on HMM: 30-254/263.0
NRYTNILPNPRTRVRLEDEYEPwtSVSTYINANYIAGYsSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRyneakkV
|||.||||. .|||.|..| ..  . |.||||||| |. .....|||. |||..|.| ||||||  |.. |||.|  .|.|. ||.||||          
nRyknilpydhtrVklkkeekk..egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees......g

GDRIYGHISVAVCSGEQHP-GYILTHIRLRKGK--EEQLLRHYWFQNWPDHGVP-SAEGAHQVIAMMQNVRAFCeeqrQGPPIVHCSAGIGRTGTFIAID
|   .|.||| . . |...  .||....|.| .  |.. ...|...|||||||| |..   ... .... .       .|| .||||||.||||||..||
gketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts....sgpivVhCsaGvgRtgtfvtid

QAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 ... |||. .||. .|| ..||.| ||||  .|| ||
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfi
PTPc_SM00194 1-234 3.5e-72 238.2 In-house 30-254 (263) alignment 
Range on Protein: 1-234
Range on HMM: 30-254/263.0
NRYTNILPNPRTRVRLEDEYEPwtSVSTYINANYIAGYsSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRyneakkV
|||.||||. .|||.|..| ..  . |.||||||| |. .....|||. |||..|.| ||||||  |.. |||.|  .|.|. ||.||||          
nRyknilpydhtrVklkkeekk..egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees......g

GDRIYGHISVAVCSGEQHP-GYILTHIRLRKGK--EEQLLRHYWFQNWPDHGVP-SAEGAHQVIAMMQNVRAFCeeqrQGPPIVHCSAGIGRTGTFIAID
|   .|.||| . . |...  .||....|.| .  |.. ...|...|||||||| |..   ... .... .       .|| .||||||.||||||..||
gketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts....sgpivVhCsaGvgRtgtfvtid

QAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 ... |||. .||. .|| ..||.| ||||  .|| ||
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfi
0039614 (Phosphotyrosine protein) phosphatases II 1-234 2.5e-71 235.9 In-house 60-281 (297) alignment 
Range on Protein: 1-234
Range on HMM: 60-281/297.0
NRYTNILPNPRTRVRLEDEYEPwTSVSTYINANYIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRvKCARYWPTVRYneakkv
|||..|||....||.| .| .     |.||||.|. ||.  .|..||. |||..|.| ||||||  ....||| |. .| || |||.|||.         
nrykdilpydhsrvklkpedgv.dldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg......

gdrIYGHISVAVCSGEQHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVP-SAEGAHQVIAMMQNVRAFCeeQRQGPPIVHCSAGIGRTGTFIAIDQAV
    ||...| . . |...||...........|.  ..|... .||||||| |.|   ... ......| .  ...|| .||||||.||||||||.. ..
...tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael..pkggpvlVHCsaGvgRtGtfiaaylml

RCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
..||..|.|| |..|. .|..|.|.|| |.||.|.
eqlekeggvdvleavkelreqRpgavqtpsqyrfl
0040438 (Phosphotyrosine protein) phosphatases II 1-234 3.3e-71 235.5 In-house 47-268 (317) alignment 
Range on Protein: 1-234
Range on HMM: 47-268/317.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQPReYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryNEAKKV
|||..|||....||.| .. .     |.||||.|. |.. ... .||. |||.||.| ||||||  ..  ||| |. .| ||.|||.|||.   .| ...
nrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl...getlty

gdriyGHISVAVCSGEQHPGYILTHIRLR--KGKEEQLLRHYWFQNWPDHGVP-SAEGAHQVIAMMQNVRAfceeQRQGPPIVHCSAGIGRTGTFIAIDQ
     |...| ..| |...|..|.....   ...|.  ..|... .||||||| | .   . . .......    ...|| .||||||.||||||||.. 
.....gdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale....dpggpvlVHCsaGvgRtGtfiaayl

AVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
....||..|.||  ..|. .|..|.|.|| |.||.|.
mleqlekeggvdveeavkelreqRpgavqtpeqyrfl
Y_phosphatase Protein-tyrosine phosphatase 1-234 1.3e-70 232.8 Pfam-A 5-229 (235) alignment 
Range on Protein: 1-234
Range on HMM: 5-229/235.0
NRYTNILPNPRTRVRLEDEYEPWTsvstYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPtvryneAKKV
|||..|||  .|||.|... .|      ||||||. ||. .....||. |||..||| ||||||  |. .||| |  .|.||.|||.|||       .. 
nRykdilpydktrvklkgsegpsd....YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp......eeee

GDRIYGHISVAVC-SGE-QHPGYILTHIRLRKGKEEQ---LLRHYWFQNWPDHGVPsaEGAHQVIAMMQNVRAFCeEQRQGPPIVHCSAGIGRTGTFIAI
.   ||.|.| .  . . .. .|.|....|.| |||.    .......||||||||  | ..... ....|.    |...|| .||||||.||||||.|.
esltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp..espkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfval

DQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
| ....||...||| |||| ..||.| ||||  .||.|.
dilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl
Y_phosphatase Protein-tyrosine phosphatase 1-234 1.3e-70 232.8 In-house 5-229 (235) alignment 
Range on Protein: 1-234
Range on HMM: 5-229/235.0
NRYTNILPNPRTRVRLEDEYEPWTsvstYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPtvryneAKKV
|||..|||  .|||.|... .|      ||||||. ||. .....||. |||..||| ||||||  |. .||| |  .|.||.|||.|||       .. 
nRykdilpydktrvklkgsegpsd....YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp......eeee

GDRIYGHISVAVC-SGE-QHPGYILTHIRLRKGKEEQ---LLRHYWFQNWPDHGVPsaEGAHQVIAMMQNVRAFCeEQRQGPPIVHCSAGIGRTGTFIAI
.   ||.|.| .  . . .. .|.|....|.| |||.    .......||||||||  | ..... ....|.    |...|| .||||||.||||||.|.
esltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp..espkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfval

DQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
| ....||...||| |||| ..||.| ||||  .||.|.
dilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl
0036941 (Phosphotyrosine protein) phosphatases II 1-234 3.5e-70 232.0 In-house 43-269 (297) alignment 
Range on Protein: 1-234
Range on HMM: 43-269/297.0
NRYTNILPNPRTRVRLEDEYepwtsvSTYINANYIAGYsSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAKkv
|||..|||...|||.|.||       | ||||.|. || ...|..||. |||.||.| ||||||  ... ||| |. .| ||.|||.|||.   .. .  
nRykdilpydhtRVklddeg......sdYinAsyvdgy.dlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegeslt..

gdriYGHISVAVCSGEQ--HPGYILTHIRLRK--GKEEQLLRHYWFQNWPDHGVPS-AEGAHQVIAMMQNVRafcEEQ-RQGPPIVHCSAGIGRTGTFIA
    ||...| . | |.  ...|.|..... .  ..|.  ..|... .|||||||. ..   . | ....|.   ..  ..|| .||||||.||.|||||
....ygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl...kllpsggpvlVHCsaGvgRsgtfia

IDQAVRCLE---ETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.| ....||   ..|.|| |..|  .|..| |.|| ..||.|.
adlmlqqledklkeggvdileavkklReqRpgavqtleqyrfl
0047943 (Phosphotyrosine protein) phosphatases II 1-234 4e-70 231.7 In-house 42-264 (273) alignment 
Range on Protein: 1-234
Range on HMM: 42-264/273.0
NRYTNILPNPRTRVRLedeyE--PwtsvSTYINANYIAGYSSQPReYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVryneak
|||..|||. ..||.|    .  .    | ||||.|. || .... .||. |||.||.| ||||||  ... ||| |. .| ||.|||.|||.       
nrykdilpydhsrvkl....gdgg....sdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwple......

kVG--DRIYGHISVAVCSGEQHPGYILTHIRLRK--GKEEQLLRHYWFQNWPDHGVP-SAEGAHQVIAMMQNVRAFCEEQrqGPPIVHCSAGIGRTGTFI
 .|    .||...| . | |....|......|..   .|.   .|... .||||||| | |   . | ....... . ..  || .||||||.|||||||
.ggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn..gpvvVHCsaGvgRtgtfi

AIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
|.| ....||..|.|| |..|. .|..| |||| |.||.|.
aldllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0045450 (Phosphotyrosine protein) phosphatases II 1-234 1.4e-68 227.3 In-house 59-296 (307) alignment 
Range on Protein: 1-234
Range on HMM: 59-296/307.0
NRYTNILPNPRTRVRLEDEYEPwTSVSTYINANYI--------AGYSSqPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTV
|||..|||...|||.| .. .   . | ||||.|.         || . .|..||. |||..|.| ||||.|  .. .||| |. .| ||.|||.|||. 
nrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde

ryNEAKKVGDriyghISVAVCSGEQHPGYILTHIRLR---KGKEEQLLRHYWFQNWPDHGVPSaeGAHQVIAMMQNVRAFCEEQ-RQGPPIVHCSAGIGR
  .| .  |.     . | . | |...||.......    . .|.  ..|... .|||||||.     ....... ||...||  ..|| .||||||.||
..geeltygn.....ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp..sfeelldfieevrkaleelpkggpvlVHCsaGvgR

TGTFIAIDQAVRCLEETGE---VDCLQIVANMRKHRGGMVQHPQQYEFI
||||||.. . |.||..|.   || |..|. .|..|.|.|| |.||.|.
tGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfl
0043336 (Phosphotyrosine protein) phosphatases II 1-234 2.8e-68 225.7 In-house 49-269 (278) alignment 
Range on Protein: 1-234
Range on HMM: 49-269/278.0
NRYTNILPNPRTRVRLEDeyEPWTSVSTYINANYIAGYSSQPReYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPtvryneakkV
|||..|||....||.|..  ..    |.||||.|. ||. ... .||. |||..|.| ||||||  ... ||| |. .| ||||||.|||          
nrykdilpydhsrvklsl..lggdldsdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.........g

GDRIYGHISVAVCSGEQHPGYILTHIRLR--KGKEEQLLRHYWFQNWPDHGVPSaeGAHQVIAMMQNVRAFCEeQRQGPPIVHCSAGIGRTGTFIAIDQA
|   ||...| . . |....|.......   . .|..  .||.. .|||||||.     ... ... || ..|  ..|| .||||||.||||||||.. .
gsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe..slsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyll

VRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
...|| .|.|| ...|. .|..|.|.|| |.||.|.
leqlekeggvdleeavkelreqRpgavqtpsqyrfl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1-234 3.9e-67 221.6 In-house 50-272 (318) alignment 
Range on Protein: 1-234
Range on HMM: 50-272/318.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryneakkV
|||.|||.  .|||.|..  .  .  | ||||||| || .. ..|||| .|| .||| ||||||  .|  ||| | ..|.|..|..||||          
nryanilaydhtrvkLqmleg..eegsDyinanyidGyrrk.kayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPs........k

GDRIYGHISVAVCSGEQHPGYILTHIRLRKGK--EEQLLRHYWFQNWPDHGVPSAEgaHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQA
| | ||.. | . .  .   |.| ...... .  |..  | | . .|||.|||.     ........|..  ... .|| .||||||.||||.|||.|  
gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg..aslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdil

VRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.. ... . || .|.| ..|..|  |||  .|||||
lerikaealvDvfqtvkqlreqrnlmvqtedqyefi
subfamily_PTPN6_pd Subfamily PTPN6 1-234 1.9e-66 219.1 In-house 58-289 (306) alignment 
Range on Protein: 1-234
Range on HMM: 58-289/306.0
NRYTNILPNPRTRVRLEdeyEPWTSVSTYINANYIAGY-SSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEakk
||| ||||   ||| |.   || .. |.||||||| .   .. ..|||. | |..|.. ||||||  .|  |||||  .|.|. |||||||..  .|   
nryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeeke...

vgdRiYGHISVAVCSGEQHPGYILTHIRLR---KGKEEQLLRHYWFQNWPDHGVPSAEGahQVIAMMQNVRAFCEEQR---QGPPIVHCSAGIGRTGTFI
   . ||.|||  .| ...  ||| ....    |.|||. ...| |..|||||||.  |  .|......|..  || .   .|| .||||||||||||||
...e.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpg..avLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfi

AIDQAVRCLEETG---EVDCLQIVANMRKHRGGMVQHPQQYEFI
 ||  .. .|..|   ..|  ..|  .|..| |.||  ||| |.
viDillkliekkgldadidiqklvksvreqrsglvqteqqykfv
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-234 7.3e-66 217.4 In-house 52-275 (319) alignment 
Range on Protein: 1-234
Range on HMM: 52-275/319.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEakkv
|||.|||.  |||| | .  .  .  |.||||..| ||  . ...||...||.|||| ||||||  .|  .|| | . |...||. .|||.  ..|    
nryqnilaydrtrvvlseldg..vegsdyinasfidgyqer.ekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfee....

gdriYGHISVAVCSGEQHPGYILTHIRLRKGKEEQ---LLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQ
    ||.. | . . |.  .||  .. |.| ..|     . |. ...||||.||    | .........|   |.. .|| .||||||.|||||||..| 
....yGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPek..atslldllkrirksrektqsgPivvhCsaGvGRtGtfivlda

AVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
..  ..| | .|  ..| ..|  |  |||.|.||.||
mlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfi
0045098 (Phosphotyrosine protein) phosphatases II 1-234 1.4e-65 216.8 In-house 37-264 (278) alignment 
Range on Protein: 1-234
Range on HMM: 37-264/278.0
NRYTNILPNPRTRVRledeyepwtsvsTYINANYIAGYssqPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryNEAKKV
|||..|||....||.             ||||.|| ||   |...||. |||..|...||||.|  ....||| |. .| ||.|||.|||    .. .  
nRykdilpydhsrVk............dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe...ggslty

gdriyGHISVAVCSGEQHPGYILTHIRLR------KGKEEQLLRHYWFQNWPDHGVPSAEGAHQVIAMMQNVRAFCE------------EQRQGPPIVHC
     |...| . | |... |.|......      .. |.  ..|... .|||||||| .   ... ... .|....            ....|| .|||
.....gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC

SAGIGRTGTFIAIDQAVRCLeEtGEVDCLQIVANMRKHRGG-MVQHPQQYEFI
|||.|||||..|..   ..| | | || |..|. .|..|.| .||...||.|.
saGvgRtGtlvaaylmlell.e.ggvdlleavkelrsqRpglavqnleqyrfl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1-234 8.7e-65 213.6 In-house 45-268 (281) alignment 
Range on Protein: 1-234
Range on HMM: 45-268/281.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYneakkv
|||.||     |||..... |  .. . |||||...||. ...||||. ||. ....|||.|||  |  |||| |  .|.|..|| ||||  .       
nrYsnivaYDatrvkvtpnee..nkntDYinanfvpgyk.gekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddns......

gDRIYGHISVAVCSGEQHPGYILTHIRL-RKGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQAV
 . .||.. |   . |... ||  ...| |.. |.. ...  ...|||||||.   .....   ..|. . |.... | ..|||||.|||||.||.|..|
.elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPat..tkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlv

RCL-EETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
. . .|. |.|  ..||..||.|  |||   ||||.
kaveaeleeldvkavvaelrkernlmvqtvvqyefv
0042113 (Phosphotyrosine protein) phosphatases II 1-234 2.2e-64 212.5 In-house 13-235 (245) alignment 
Range on Protein: 1-234
Range on HMM: 13-235/245.0
NRYTNILPNPRTRVRLEdeYEPWTSVSTYINANYIAGYSSQPReYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryNEAKKV
|||..|||...|||.|    ...  .|.||||.|. ||   |. .||. |||..|.|.||||.|  .. .||| |. .| ||||||.|||.   .| ...
nrysdilpydhtrvkls..pdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl...geslty

GDriyghISVAVCSGEQHPGYILTHIRLR--KGKEEQLLRHYWFQNWPDHGVPS-AEGAHQVIAMMQNVRAFceeQRQGPPIVHCSAGIGRTGTFIAIDQ
||     ..| . | |....|.......   . .|..  .||.. .|||||||.  |   ... ......|     ..|| .||||||.||||||||.. 
gd.....ftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae...dsngpvlVHCsaGvgRtGtfiaayl

AVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
....||....|.  ..|. .|..|.|.|| |.||.|.
mleqlekelgvsleeavkelrsqRpgavqtpsqyrfl
0040439 (Phosphotyrosine protein) phosphatases II 1-234 3.8e-64 212.0 In-house 15-238 (249) alignment 
Range on Protein: 1-234
Range on HMM: 15-238/249.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQPReYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryNEAKKV
|||..|||....||.|..  .     | ||||.|| || ...| .||. |||..|.|.||||.|  .. .||| |. .| ||.|||.|||.   .. ...
nrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl...ggsley

gdriyGHISVAVCSGEQHPGYILTHIRLR--KGKEEQLLRHYWFQNWPDHGVP-SAEGAHQVIAMMQNVRAFCeeQRQGPPIVHCSAGIGRTGTFIAIDQ
     |...| . | |....|......|   . .|.   .|... .||||||| | | . . | ....... .   ..|| .||||||.||||||||.. 
.....gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel..pkggpvlVHCsaGvgRtGtfiaayl

AVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
....||....|| ...|. .|..|.|.|| |.||.|.
mleqlekelgvdleeavkllrsqRpgavqnpeqyrfl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1-234 2.1e-63 209.1 In-house 51-271 (288) alignment 
Range on Protein: 1-234
Range on HMM: 51-271/288.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRynEakkv
||| ||||   .||.|..  |  .. . ||||.||.|. .. ..|||. ||| .|.. ||..|.  |.  ||| | ..|.|. || .|||.    .    
nRyrnilpyDekrvklkklee..eagaDYinasyidgekkk.kkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdad..k....

gDRIYGHISVAVCSGEQHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEEQrQGPPIVHCSAGIGRTGTFIAIDQAVR
  . ||.. | . . ..   ..| .. | | |.|  . .| .. ||||||| .  ..........|    ... .|| |||||||.||||||||.|... 
.pknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPes..kapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalid

CLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 .||.  .| . .||..||.|  .||  .|||||
aveeedyiDvagtvaklRkqRallvqtlkqYefi
0037934 (Phosphotyrosine protein) phosphatases II 1-234 2e-60 199.7 In-house 14-234 (243) alignment 
Range on Protein: 1-234
Range on HMM: 14-234/243.0
NRYTNILPNPRTRVRLedeyEPwtsvSTYINANYIAGYssqPReYIAAMGPLDNTIEA----FWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPtvryne
|||..|||....||.|    |.    | |||||.| ..   || .||  |||..|.|     ||||.|  .. .||| |. .| ||.|||.|||      
nrysdilpydhsrvkl....eg....sdyinanliyvt...pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp......

akkvGDRIYGHISVAVCSGEQHPGYILTHIRLRK---GKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEE-------QRQGPPIVHCSAGI
    |.  ||...| . | |....|......|.    .....| .||.. .|||||||.     ....... ||.|.||        ..|| .||||||.
....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPds..pedlldfldevrefieellsllaldsggpvlVHCsaGv

GRTGTFIAIDQAVRCLeetgEVDCLQIVANMRKHRGG-MVQHPQQYEFI
|||||.||..   ..|    .|| ...|. .|..|.| .|| |.||.|.
gRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrfl
subfamily_PTPN12_pd Subfamily PTPN12 1-234 2.4e-60 198.9 In-house 44-269 (290) alignment 
Range on Protein: 1-234
Range on HMM: 44-269/290.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSqPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAKkv
||| .|||   .|| |. . |  .  | |||||.| | .. . ||||| ||| .|.. ||||.| ..   .||   ..| |. ||.||||    .| .  
nrykDilPydksrvelskiee..eegsdYinanfikgveg.kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeele..

gdriYGHISVAVCSGEQHP-GYILTHIRLRKGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEeQRQGPPIVHCSAGIGRTGTFIAIDQAV
    .|...| . . ..   ....  ..... ||.. .. . ...||||||||.  |.........|| . | . . | .||||||.||||| |||| . 
....fgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPss..aksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvr

RCLEETG---EVDCLQIVANMRKHRGGMVQHPQQYEFI
. |..     |.|  ..|...||.|  .||  .|||..
ellkaekipeeldvfdlvlelrkqraalvqtkeqyelv
subfamily_PTPN9_pd Subfamily PTPN9 1-233 2.9e-60 198.8 In-house 46-281 (297) alignment 
Range on Protein: 1-233
Range on HMM: 46-281/297.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAKkv
||||..|   .||| |. . |  .. | |||||.. ||  |.. .||. |||..|.. ||||||  .   ||||| ..|.||.||..|||. . . |.  
nrytdvlcydetrvvlakvde..deasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessae..

gdriYGHISVAVCSGEQHPGYILTHIRLR--KGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAF-----------CEEQRQGPPI-VHCSAGI
    .|..||.. . |..  |  . . ..  | .|.. . |. |  |||.||||.  |.... ....||              . . .|||| |||||||
....fgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPss..aaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGi

GRTGTFIAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEF
|||||||..| ..  |||.| ||  . |  .|. |  ..| |.||||
GrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyef
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1-234 8.6e-60 197.5 In-house 60-282 (298) alignment 
Range on Protein: 1-234
Range on HMM: 60-282/298.0
NRYTNILPNPRTRVRLEDEYepWTSVSTYINANYIAGYSSQPrEYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVryneakkv
|||..|..   .||.||.|       |.|||| .. .|. ..  .||. .|| .|.| |||||.  .. .||| |.. |....|. .|||..        
NRyadiialdssRvvLeked..adeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPde........

GDRIYGHISVAVCSGEQHPGYILTHIRLRKGK--EEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQA
| . ||.|.| . | |..  .| ... . | |  .|. .|.  | .|||.|||.   |. |......|||  ..  . | ||.||||.||.|||||||  
gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpen..atsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsv

VRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.  ...   || .|.|  .||.| |.||  .|| ||
lervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfi
subfamily_PTPN3_pd Subfamily PTPN3 1-234 1e-57 190.2 In-house 45-267 (280) alignment 
Range on Protein: 1-234
Range on HMM: 45-267/280.0
NRYTNILPNPRTRVRLEDeyepwtSVSTYINANYIAGYS---SQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvrYNEA
||| .|||   |||.|..      | . ||||||.   .   ..   |||. |||..| . ||.|||  ||  ||| | ..|.||||| .|||.   .. 
nryrdilpydatrvklke......setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe..tede

KKvgdriYGHISVAVCSGEQHPGYILTHIRLRKGK--EEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFcEEQRQGPPIVHCSAGIGRTGTFIAI
 .     ||..|| . . ...  |.| .. |.. .  ||. . .  . .|||||||.   ..... ....||.   . .. | .||||||||||| .|..
le.....ygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPdd..sadflefvervrkl.rsgkeePvvvhCsaGigrtGvlill

DQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
. |.  .|.. .|  |.|| .||  |. .|| ..||.|.
etalalieaaepvypldivrtmrdqramlvqtasqykfv
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1-234 8.2e-57 187.3 In-house 13-234 (250) alignment 
Range on Protein: 1-234
Range on HMM: 13-234/250.0
NRYTNILPNPRTRVRLEDEYepWTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVkCARYWPTvrynEakkv
|||..|..   .|| || |       | |||| .. ||. . . .||. ||| .||| |||||.  || .||| | . |.... . .|||.    |    
nryadiialdssrvvLekek..gdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv....e....

GDRIYGHISVAVCSGEQHPGYILTHIRLRKGKEEQL--LRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQA
. ..||.. | . | |..  |. ... | | |...   .|.. | .||| |||    |. |......|.|  ..  ..| ||.||||.||.|.|||||  
kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPev..atavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

VRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.  |..   ||  ...  .||.| ..|.  .|| |.
lerlkkekvvdvfkvikvlrkdrphavesleqyvfv
subfamily_PTPN13_pd Subfamily PTPN13 1-234 8.7e-57 187.5 In-house 41-261 (273) alignment 
Range on Protein: 1-234
Range on HMM: 41-261/273.0
NRYTNILPNPRTRVRLEDEYEpwtsvstYINANYIAGY-SSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRyNEAKK
||| |.||  .|||.|.||         ||||..|      .  ||||. ||| .|.. ||.|||  |.  |.| |   |.|.||| ||||  . |.  |
nryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesk.nkklk

vgdrIYGHISVAVCSGEQHPGYILTHIRLRKG--KEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEeqRQGPPIVHCSAGIGRTGTFIAIDQ
    ... . |..   ... |. . .. ...   .| . . |  | .||||||||.  | ... ....|| . .   .|| .|||||||||.||.|.|| 
....vsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPss..aaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidv

AVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
..  .|   |.|  .|| ..|. | |.||  .|| |.
vlglierdkefdvkeivrklreqrqgvvqtkdqyifv
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1-234 1.7e-56 186.6 In-house 50-275 (305) alignment 
Range on Protein: 1-234
Range on HMM: 50-275/305.0
NRYTNILPNPRTRVRLEDEYEPWtsVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAKkv
||...| . .  |..|  . .     | ||||.|. ||...  .||.| |||.||.. |||... .|   ||| | ..|.|. || .|||.   .. .  
nrlkeitlldddriiltekesld..dsdyinasyvdgykrk.kkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekke..

gdriYGHISVAVCSGEQHPGYILTHIRLRK---GKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQ
    .|..|| . | .. ..||  .... .    ||.. . .| . .|||||||    |  .. ....|.   ..... | .||||||.||||.|||.| 
....fgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqf..atsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdi

AVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
|.  |.. ..||  ... ..|..| .|||  .|| |.
alerlkkEevvdvfevlkqlRskrmkmvqtldqYvfl
subfamily_PTPRK_pd Subfamily PTPRK 1-234 3e-56 185.5 In-house 47-269 (314) alignment 
Range on Protein: 1-234
Range on HMM: 47-269/314.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPtvrynEAkkv
||...||.  |.||.|    .   . | ||||..| .|  .|...|.. |||..|.. |||.|.  .. .||| | ..|.||||| .|||     |    
nrsgdilaydrsrvflitidg..dpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP.....ed...

GDRiYGHISVAVCSGEQHPGYILTHIRLRK----GKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEEqRQGPPIVHCSAGIGRTGTFIAID
..  ||.| | . . | .  ..    |..|     .| ...|.. | .||||.||    |. .......| .  || ..|. .|||||| ||||||||||
tev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvs..atgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaid

QAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
  .  .|. | ||  ..| ..|...  ||.  .|| ||
ivldmieregvvdvfnavktlrsrkvnmveteeqykfi
subfamily_PTPRA_pd Subfamily PTPRA 1-234 5.9e-56 184.7 In-house 62-287 (330) alignment 
Range on Protein: 1-234
Range on HMM: 62-287/330.0
NRYTNILPNPRTRVRLEDEYepWTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvrynEakkv
||. ||||.  .|| |       .  | |||| .| ||  .  ..||| ||...|.| ||||.|  || .||| | . |. . |||.|||.    |    
nrvvnilPydfsrvilsvke..GveesdyinasfidGykek.dkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd....e....

GDRIYGHISVAVCSGEQHPGYILTHIRLR------KGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAfCEEQRQGPPIVHCSAGIGRTGTFIA
|   ||.| |.|   .    | . .. ..      . |...|.| . |. ||| |||.   .  .. ....|.. ...|  || .||||||.|||||||.
GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe..piGmlkllkkvkk.lnqqsagpivvhcsaGvGrtGtfiv

IDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.|. .  ..  . ||  ..| ..|. |  |||  .|||||
ldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefi
subfamily_PTPRG_pd Subfamily PTPRG 1-234 2.6e-55 182.7 In-house 51-279 (563) alignment 
Range on Protein: 1-234
Range on HMM: 51-279/563.0
NRYTNILPNPRTRVRLEDEYEPWTSVsTYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryNEAKKV
|||.||..  |.||.|..  .   .   ||||||| ||  . ...||. ||| .|.. ||||.|  ..  ||| | . |.|| || .|||.   .|....
nRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyq.kskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk...desety

GDRIYGHISVAVCSGEQHPGYILTHIRLRKGKE---EQLLRHYWFQNWPDHGVPSAEgAHQVIAMMQNvrAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQ
|      |.  | .  .    .. ...|.|.|.   |.| |.| . .|||||||. . . ..| . ..  .  ...  || .||||||.|||||.|..| 
galqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehs.lpvLifvkks..saankaeaGPivvHcsaGvgrtGtyivldt

AVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 .. ...   |. ....  .| .|  .||   || |.
llkqiqqenavnvfgflkhiraqRnflvqteEqYifl
subfamily_Ptp69D_pd Subfamily Ptp69D 1-234 1.3e-54 180.4 In-house 52-278 (307) alignment 
Range on Protein: 1-234
Range on HMM: 52-278/307.0
NRYTNILPNPRTRVRLEDEyePWTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVryneakkv
||| .| .  .|||.|.    . .  |.||||..| ||  . ...||| .|...||. ||||..  ..  ||| . . |. | |||.|||          
nRyedikafDktRvkLkki..ngkedsdYinasfikgykek.kkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie........

GDRIYGHISVAVCSGEQHPGYILTHIRLRKGK-------EEQLLRHYWFQNWPDHGVPsaEGAHQVIAMMQNVRAFCEEQrQGPPIVHCSAGIGRTGTFI
    ||.| | . | |.|. ||  .. . | |       ... .  | ...|.|  ||  | |. .. ....||   . . ..| .|||||| ||.|.|.
devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvP..evargllklieqvrelykln.rsPivvhCsaGvgrsgifv

AIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
|.|  .  |..  .||  ..| ..|..|  .||  .||.|.
aldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvfl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1-234 3.8e-53 175.4 In-house 48-269 (315) alignment 
Range on Protein: 1-234
Range on HMM: 48-269/315.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryNEAKKV
||| ||||  ..||.||   .  .  | |||| || .. .. . |||. |||. ... |||||.  |  .||| | . |. ..||..|||    ..|. |
nryknilPldsarvklevidd..sPdsdyinasyiksvddd.kayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPd...rkadsv

GdriYGHISVAVCSGEQHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVPSAEGahQVIAMMQNVRAFcEEQRQGPPIVHCSAGIGRTGTFIAIDQAVR
    .| |.|.. | |.  . .  .. .||..| . .  . |..|||.||.   .   .. ....|.|  ..... . .||||||.|||| .|.||. | 
e...fGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqts..sllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevva

CLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 ...|  || ...| |.|..|  .||  ..| ||
qikrtrsvdvfnfvknlrakrpylvqteeeyafi
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1-234 4.4e-53 175.3 In-house 55-276 (297) alignment 
Range on Protein: 1-234
Range on HMM: 55-276/297.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSqprEYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRvKCARYWPTVRYNEakkv
.||.||||  . ||.|.   .     | |.|| .. |.     ..|.   | ..|.. ||.||.  .  .||| .   |. . ||||||.    ..    
sRYkniLPydssRvkLaivnd..dpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt....

gdriYGHISVAVCSGEQHPGYILTHIRLRKGK--EEQLLRHYWFQNWPDHGVPSAEGAHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQA
    .|..|| . | ..  |.|  .. ..|||   ..... | | .|||. |.  . |.... ....||   ... .|| .|||.||.|||| ...||. 
....fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsv

VRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
|   ... ||| ...|  .|..|  .||  .||.|.
vaeakrekevdifglvkklrqerpylvqtkeqykfv
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1-234 1.1e-52 173.8 In-house 47-268 (515) alignment 
Range on Protein: 1-234
Range on HMM: 47-268/515.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAKkv
||| ||||  ..||.||   .     | |.|| || .. .. . |||. ||.. ... |||.|.  .  .|.| | . |. ..||..||| .  .  |  
nryknilPydsvrvklevind..nPhsdyfnasyipsfdnd.kayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk..

gdriYGHISVAVCSGEQHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEeQRQGPPIVHCSAGIGRTGTFIAIDQAVR
    .|.|.| . | |   | |  .... ||.. . .  . |..|||.|||    .  .. ....|.|  . | . | |.|||||.|||| .|.||. | 
....fGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkh..tssllklikevkadhg.qythpliihcsaGvGrtGvvisidsvva

CLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
  ..|  || ...| |.|..|  .||  .|| ||
hakttrmvdvfnfvtnirqkrpylvqtqeqyafi
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1-234 1.9e-52 173.6 In-house 65-283 (319) alignment 
Range on Protein: 1-234
Range on HMM: 65-283/319.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSqPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTpmmeqgRVKCARYWPtvryNEakkv
||..|||.  ...|.||         | |||| ...|| . .  |||| ||||||.. ||||.|  .. .||. |      . ||..|||    ..    
nriinilafdknvvklerliG..eefsdyinasfvtGyqr.kdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywp....lk....

GDRIYGHISVAVCSGEQHPGYILTHIRLRK-GKEE--QLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCE-EQRQGPPIVHCSAGIGRTGTFIAID
..  ...  | | | |.   |.. .|.| . |||.  . .. . |. |||.|||    . ... ....|| . . |. . . .||||||.||||..|..|
ivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdy..psdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivld

QAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
  .  ..|   ||  ..| ..|. |  .||.  || ||
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfi
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1-234 6.5e-52 171.8 In-house 29-247 (284) alignment 
Range on Protein: 1-234
Range on HMM: 29-247/284.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSqPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTpmmeqgRVKCARYWPtvryNEakkv
||...||.  ...|.||         | |||| .|.|| . .  |||. ||||||.. ||||.|  .. .||. |      . ||..|||    ..    
nrighilafdknvvklerliG..eefsdyinasfitGyqr.kdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp....lk....

GDRIYGHISVAVCSGEQHPGYILTHIRLRK-GKE--EQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCE-EQRQGPPIVHCSAGIGRTGTFIAID
..  ...  | | | |.   |.. .|.| . |||   . .| . |. |||.|||    . ........|| . . |. . . .||||||.||||..|..|
ivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdy..psdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld

QAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
  .  ..|   ||  ..| ..|. |  .||.  || ||
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfi
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1-234 9.6e-52 170.6 In-house 50-275 (290) alignment 
Range on Protein: 1-234
Range on HMM: 50-275/290.0
NRYTNILPNPRTRVRLEDEYEPWTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryneaKKV
||..||...   |. | .  .       |||| || ||. . ..|||. ||. ||.  ||...|  |...||| | ..|.|.|||  |||.      ...
nRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpd......sdt

GDriYGHISVAVCSGEQHPGYILTHIRLRKGKE---EQLLRHYWFQNWPDHG-VPSAEGAHQVIAMMQNVRafcEEQRQGPPIVHCSAGIGRTGTFIAID
 .  ||..|. . . |.. .|| ....... ..   .| . .| ..||...| |.  ..  .||. |.. .     . ... .||||...||...|.|..
ka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktq...rkrgntsivvHCSdtvgrsavfcaaa

QAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 ..   . .| .| .|.. ..|  . |.||  |||..|
ttinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgi
subfamily_PTPN1_pd Subfamily PTPN1 1-233 1.6e-51 169.8 In-house 36-262 (290) alignment 
Range on Protein: 1-233
Range on HMM: 36-262/290.0
NRYTNILPNPRTRVRLEDEYEpwtsvsTYINANYIAgYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAKKV
||| .. |   .|..||..         ||||. .       |.|| . ||| ||.. ||.|||  || |.||   ..|....|||.|||.   ... ..
nryrdvspydhsrikleradn......dyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekelll

GDRiygHISVAVCSGEQHPGYILTHIRLRK--GKEEQLLRHYWFQNWPDHGVPSAEGAhqVIAMMQNVR-AFCEEQRQGPPIVHCSAGIGRTGTFIAIDQ
 |    ...| . | |..  |.. ...| .   .| . . |. .  ||| |||.. .|   . ....|| . .  . .||...||||||||.|||. .| 
edt...klkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaa..flkflfkvresGslssdvGpavihcsaGiGrsGtfclvdt

AVRCLEETGE---VDCLQIVANMRKHRGGMVQHPQQYEF
 .  .|....   ||  . . ..||.| |..| ..| .|
clvliekkddlssvdikkvllelrkyrlGliqtadqlrf
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1-233 3.2e-50 165.5 In-house 42-268 (287) alignment 
Range on Protein: 1-233
Range on HMM: 42-268/287.0
NRYTNILPNPRTRVRLEDEYEpwtSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVryNEAKKV
|||...||   ||| |  | |     | ||||||.|.|  .  ..||| ||.  |.  |||.|.  .| .... |  .|..| || .|||    .   .|
nryadvlPiddtrvllsaege...lGsdyinanyvasytdd.eafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer..evPmrv

GdriyGHISVAVCSGEQHPGYILTHIRLRK--GKEEQLLRHYWFQNWPDHGVPSA-EG-AHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAID
|    |.  |..    ..| |    .|| .  ..| .... . . .|||.... .  | .  |. . |.. .  . .  ||..||...||||.|...|. 
G....GysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatl

QAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEF
  |. ||..|.||  ..|. .|..| ..|| . |. .
vlvsrledlGrvdvaavvirlreyraalvqavvqlrl
subfamily_PTPN23_pd Subfamily PTPN23 1-233 1.7e-48 159.9 In-house 47-271 (288) alignment 
Range on Protein: 1-233
Range on HMM: 47-271/288.0
NRYTNILPNPRTRVRLEdeyepwTSVSTYINANYIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvRYNEAKKV
||...|||  ..|| |.       |   |||| .. . |..  ..||. .||..|.  ||.||.  ||. ||| .   |.|. |..||||. . .|..| 
nrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPe.dkgetvkf

GDriyghISVAVCSGEQHPGYILTHIRL--RKGKEEQLLRHYWFQNWPDHGVPSAEgaHQVIAMMQNVRA---FCEEQRQGPPIVHCSAGIGRTGTFIAI
||     .||.. | .. . ..  ...|  .. .. . ..|  ...||..|||..   .........|..     ... . | .||||||.||||.|  .
gd.....lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasP..etllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalv

DQAVRCLEE-TGEVDCLQIVANMRKHRGGMVQHPQQYEF
  ||| ||.  | .| .|.|  .|. |  |||. .|..|
yaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkf
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1-234 5.8e-48 158.3 In-house 51-270 (287) alignment 
Range on Protein: 1-234
Range on HMM: 51-270/287.0
NRYTNILPNPRTRVRLEdeyepwTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryneAKKv
||.|.||.    || |.           |||| .| ||... ...|.| .|. ||.  ||....  . .|||| .  .|. . .| .|||.      |  
nRltqilvpdnyrvllk......gehpdyinavfidgykek.kafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpe.....eks.

gdRIYGHISVAVCSGEQHPGYILTHIRLRK---GKEEQLLRHYWFQNWPDHG-VPSAEGAHQVIAMMqnVRAfCEEQRQGPPIVHCSAGIGRTGTFIAID
   ..|. .... . |.. |||  ......    ...| .. | . ||...| |.. .    ||  |  ...    . ... .||||...||...|.|..
..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieem..ykt.qrkrgntsivvhCsdtvGrsamfcaaa

QAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 ...  .. | .| .|.. ..|  . |.||  .||.||
ttinkckteGviDvfqvlksqriqkpgsvqtveqykfi
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1-234 7.8e-48 157.8 In-house 37-258 (283) alignment 
Range on Protein: 1-234
Range on HMM: 37-258/283.0
NRYTNILPNPRTRVRLEDEYEpwtsvsTYINANYIA--GYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPtvryneak
||. .|.|  . ||.|. | .      .|||| .|       | ..||.| .|||.|.  ||.||.  |  |||| |...|. |.||..|||        
nrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP........

KVGDRIYGHISVAVCSGEQHPGYILTHIRLRKG---KEEQLLRHYWFQNWpdhgvpSAEGAHQVIAMM---QNVRAFCEEQRQGPPIVHCSAGIGRTGTF
| |   ||   |..     .  .|   . ||.    |.. || || ...|         |   .|  .     |..   |...|| .||||.|||||..|
krGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW......leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavf

IAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
||.  .|  .     ||  ..| .||..| ..||  .|| ..
iaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1-234 5.8e-47 155.1 In-house 53-271 (315) alignment 
Range on Protein: 1-234
Range on HMM: 53-271/315.0
NRYTNILPNPRTRVRL-EDEYEPwtsVSTYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVryneakk
||| ||..  ..||.|   | .|    | |.|||.| ||. ..| |||| ||. .... |||.|.  .   ||| | ..|. . |. .|||         
nryiniiaydksrvqlpllendp...hsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.......

vgDRIYGHISVAVCSGEQHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEEQRqGPPIVHCSAGIGRTGTFIAIDQAV
  . |||.|.|.  | |..  |    .    |.. . .  . .  ||| |||    .  .. ....|. . ...  |. .||||||.|||||||..|  .
..kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpky..tiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavl

RCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
  .|    .|  ... ..|. | .|||  .||.||
dqaeaenaidvynfitgvrqnrikmvqvaeqyqfi
0041856 (Phosphotyrosine protein) phosphatases II 1-234 7.5e-45 148.1 In-house 5-163 (182) alignment 
Range on Protein: 1-234
Range on HMM: 5-163/182.0
NRYTNILPNPRTRvrledeyepwtsVSTYINANYIAGYSSQPReYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTpmmeqgrvkCARYWPtvryneakkv
|||..|||....|            ...|||||...|.  . | .||. |||..|...|.||..  .  .||. |         . .|||          
nrysdilpydhsr............dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

gdriyghisvavcsgeqhpgyilthirlrkGKEEQLLRHYWFQNWPDHGVPSaegAHQVIAMMQNVRAfceeqRQGPPIVHCSAGIGRTGTFIAIDQAVR
                               ..|.|  .|.. .|||||||.    ........ |..     ..|| .||||||.|||||..|..   .
..............................ellerlgiqylylpwpDhgvpd...ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkk

CleetgEVDCLQIVANMRKHRGGMVQHPQQYEFI
.     .|.  ..|. .|..| |||..|.|| |.
l.....gvsleeavklvrsrRpgmvitpnqyffl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1-234 7.9e-45 147.9 In-house 7-231 (237) alignment 
Range on Protein: 1-234
Range on HMM: 7-231/237.0
NRYTNILPNPRTRVRLEDEYEPwtsvSTYINANYIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAkkv
||| ||     .|| |.         | ||||.|. |.   |..|||| |||... . ||.|||  |   ||| | ..|. ..|| .|||     .|   
nrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa...

gdriYGHISVAVCSGEQHPGYILTHIRLRK---GKEEQLLRHYWFQNWPDHGVPSAEGAhqVIAMMQNVRAFCEE-QRQGPPIVHCSAGIGRTGTFIAID
    || ..|...  |.   | .  . | |    || .|.  | |  |||.|||    |  .. . .|.    .  .. || |.|||||.|||| |. ||
....ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaa..llrfrkniinrsphvsesgpwiihcsagvgrtgiflvid

QAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
  .|  .|   ||  . | .. . |  ..|  .|| ||
amlrqakekkvvdiynyvysieedrpyiiqtkdqyvfi
subfamily_PTPN14_pd Subfamily PTPN14 1-234 2.5e-44 146.5 In-house 53-288 (300) alignment 
Range on Protein: 1-234
Range on HMM: 53-288/300.0
NRYTNILPNPRTRVRLEDEYEPwtsVSTYINANYIA-GYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYnEAKK
||. ..||   .||.|    |     . ||||  |    ... |.||.| |||..|.. ||.|||  .   ||| |   |.|. |. .|.|     ..|.
nrfkdvlPyednrvelsptken...stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkles.kkkt

VgdrIYGHISVAVCSGEQHPGYILTHIRLRK--GKEEQLLRHYWFQNWPDHGVPSA-EGAHQVIAMMQNVRAFCEEQR-----QGPPIVHCSAGIGRTGT
|    .|.  |     |. . .| | ..|.    |||. . |  ...|||||||.  .|  . . ..| ||   ....     . | .||||||.|||| 
v...efgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGv

FIAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 |  |  . .||   |.|  ...| .|. |  .||   ||.|.
lilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfv
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1-231 2e-41 136.5 In-house 60-272 (290) alignment 
Range on Protein: 1-231
Range on HMM: 60-272/290.0
NRYTNILPNPRTRVRLEDEYEpwtsvSTYINANYIAGYSSqprEYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRyNEAKkv
||| ..  | .||| |.| |.       |. |||. |  .    .| . |.| .|.  .||||   |  ||||   ..|.|. ||..|.|     |.   
nrykdvvcndktrvilkdGyd.....GdyvhanyvkGlka...mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypeke.Gevl..

gdrIYGHISVaVCSGEQHPG-----YILTHIRLRKGKEeQLLRHYWFQNWPDHGVPSAEGAhqVIAMMQNVRafceeQRQGPPIVHCSAGIGRTGTFIAI
    .|.|.| .|| |...       .|.     .|||   |.|.  . |||. |. .. |  .. ... .|     .  || .|||||||||||||.||
...tfGeitv.lcseeddkdaniikktlsvrdkdsGke.hklkhlkikswpdksvalstla..llrtlrilr.....kasGpvvvhcsaGiGrtGtfvai

DQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQY
. ....| .  |.| |..|  .|. | . ||   ||
evglqilldGkeldlldlvralrnsrlnsvqvdiqy
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1-233 3.4e-41 136.4 In-house 52-279 (325) alignment 
Range on Protein: 1-233
Range on HMM: 52-279/325.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTpMMEQGRVKCARYWPtvryneaKKV
||. |...  ..|| ||   .   . | ||||.|.  .  .   ..||  || .||. .||.|   ... .|..  ....|  .|| |||       |..
nrfknvvaldksrvvletkkd..dpssdyinasylrddkkk.dvflaaqaPltatindlWrlvldWrcsvvvvln.eldlgkdrcavywp.......kem

GD-RIYGHISVAVCSGEQHPGYILTHIRLRKGK--EEQLLRHYWFQNWPDHGVPSAEGahQVIAMMQNVRAFCEEQR-----QGPPIVHCSAGIGRTGTF
|. . .| . | . . |.   |.   . ... |  | . .. . .| |.| ||.       .|...| | |  |  .      .| .||||||.||||.|
gksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpa..tlisilqlvkavservtantkastpilvhcsaGvGrtGvf

IAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEF
|..  |.  . |  .|| .. | ..||.|  ||.   || .
islysalakvieesrvdifgfvkklrkdrpsmvetvdqyil
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1-234 7.4e-41 135.0 In-house 52-271 (439) alignment 
Range on Protein: 1-234
Range on HMM: 52-271/439.0
NRYTNILPNPRTRVRLEDeyEPWTSVSTYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRvkcarYWPTvrynEakkv
||| .. .   ||| |..   |    | ||||||| ||  ... |||. || ..| . |||.|.  |.  ||| | ..|  .     |||.    .    
nrykdvgafdhtrvtlqe..ipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywps....d....

GDRIYGHISVAVCSGEQHPGYILTHIRL----RKGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAID
.. .|| |.| |    . | |..  ...     ... |. . .. .  |||. ||.   |  |. ... . .  ...  || .||||||.||||| ||.|
aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaq..ashvldflrainsandkeeygpvvvhcsagvGrtGtiiald

QAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 |.  |    .||   ||  .||.|  |||.  || ||
ialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfi
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1-234 1.8e-39 130.4 In-house 37-287 (297) alignment 
Range on Protein: 1-234
Range on HMM: 37-287/297.0
NRYTNILPNPRTRVRLEDEyepwTSVSTYINANYIAGY-SSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRyNEAKK
|||..||    |||.|        . . ||||.|..     ..  || | |||..|.. ||..|.     .||| . . |.|| ||| ||| |  .| .|
nryrdilatddtrvkllrv....iterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv.qerlk

VGDRIYGHISVavCSGEqHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVPS-AEGAHQV--------------IAMMQ--------NVRAF-CEEQRQ
 || .  ..|    | | .   ||| ..|   .|.. .||  | .||||||||  |   .               .|...        .. ..  |  |.
agdvvveflss..tsde.fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprn

GPPIVHCSAGIGRTGTFIAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 . .||||||.||.|  .  |  .  |      |   |.  .|. |  .||  .|.|..
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfell
0049772 (Phosphotyrosine protein) phosphatases II 1-234 5.8e-39 130.0 In-house 50-272 (314) alignment 
Range on Protein: 1-234
Range on HMM: 50-272/314.0
NRYTNILPNPrTRVRLedEYEPWTSvSTYINANYIAGYssqpREYIAAMGPLDNTIEAF----------WRMV--WMVKSPAIVM---------------
|||..||| . .||.|   ..|  . | ||||.|. |.    . .||. |||..|.. |          ||||  .  ..  |||               
nryldilpad.nrvil..pglpvsg.sdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLda

------TTPMMEQGRVKCARYWPTVRyneakkvgDRIYGHISVavcsgeqhpgyilthirlrkgkeEQL-LRHYWFqNWPDHGVPSAEGAHQVIAMMQNV
       ......|   .|..... .        ...| .  .                       |.| ...... ..||...|. |   .........
AlgKtpllildgngneptaadlellk........eelydpelf.......................erlgikylri.pvpDgsaplledfdeflefieea

rafceeQRQGPPIVHCSAGIGRTGTFIAIDQAVRCLeetgEVDCLQIVANMRKHRG-----GMVQHPQQYEFI
      ...|| .|||.||.||||||....  ...|     |.  .... .|. |      |... ..|||||
......dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefi
subfamily_ptpA1_pd Subfamily ptpA1 1-195 2.2e-38 127.1 In-house 51-249 (418) alignment 
Range on Protein: 1-195
Range on HMM: 51-249/418.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGysSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAKK-
||||||||  .|||.|.   .     | ||||||| |  . |...|.. ||| |||  ||||||  .   ||| .   |. |.|| ||||     |    
nrytnilpvnhtrvqlkkiqd..kegsdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsi

--VGDRIYGHISVAVCSGEQHPG--YILTHIRLRKGKEEQLLRHYWFQNWPDHGVPSAE-GAHQVIAMMQNVR--AFCEEQRQGPPIVHCSAGIGRTGTF
   |. ..|  || .    | |    |   |||    | . . .| .. |||| .|      .|..  . | .       .|. | |||||||.||||||
ygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtf

IAI
 . 
cta
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1-234 2.8e-38 126.3 In-house 44-285 (301) alignment 
Range on Protein: 1-234
Range on HMM: 44-285/301.0
NRYTNILPNPRTRVRLEDEYEPWTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAKK-
||. || . .  |. |. . .  ..  .||||.|| |||.. ...||| ||...|.  |||..|  |  .||| | . |. . || .|||. . .. .  
nrfknitvyddnriilkpkpnldlcqreyinasyidgysek.kkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefg

-----------VGDRIYGHISVAVCSGEQHpGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVpsAEGAHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGR
           . | .  ...| .  | .. |||  ... .. |. . .  .   .||..||      . |.  ...|         || .||||....|
pftvtlvneqvyPdfvirqlnvkiqdgsnn.gyierkfkvksdksswdvlqlqvtdWpqdGv..vreprtvLqviddvihrqqkigggpvvVHCSdtVsr

TGTFIAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.|...... ..      | ||  |..  .|. . |.|.  .|| .|
sGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsi
subfamily_CG7180_pd Subfamily CG7180 1-234 3.7e-38 125.9 In-house 46-282 (296) alignment 
Range on Protein: 1-234
Range on HMM: 46-282/296.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRvKCARYWPTVRyneakkv
||. ...|   .|| ||       . | |||| |. ..  ...|||   .| ..|...|||.|.  .. |.|. |  ... . ..  |||          
nrdvkvvPyDynRvvLekldG..eeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.......

gDRIYGHISVAVCSGEQHPGYILTHIRLRKG------------KEEQLLRHYWFQNWPD-HGVPSA-EGAHQVIAMMQNVRAFC-EEQRQGPPIVHCSAG
    ||.| | . . .| .      ..| |              |. ..... .. |.  . ||.  ..  ... ... .|    |.. .|| .|..| |
.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdG

IGRTGTFIAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 .|.| ..||| ..  .|...|||  . |  .|..| ..|.  ..| .|
asRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyi
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1-234 1.1e-37 124.5 In-house 12-233 (239) alignment 
Range on Protein: 1-234
Range on HMM: 12-233/239.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRyneAKkv
|||.||.   ..|| ||   .     | ||||.|.  |   |. |||. | .  .   ||||.|  .   ||| | ..|  . || .|||      .|  
nryanivtydhsrvvleklsn..dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst...sk..

gdriYGHISVAVCSGEQHPGYILTHIRL-RKG-KEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEeQRQGPPIVHCSAGIGRTGTFIAIDQA
    |  . |..   |    ||.  . . . |  ||. . .| |  |||.|||    |  |. . ...          | ..|||||.||||.|. ||  
....ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy..atavlglrrkitkdsl.pgarpwvihcsagvgrtgaflvidam

VRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.|  ..   || .. |  .|. |  |||  .|| ||
lrqakkqktvdifnyvkairedrphmvqtseqyvfi
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1-234 1.1e-37 124.5 In-house 11-232 (239) alignment 
Range on Protein: 1-234
Range on HMM: 11-232/239.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRyneAKkv
|||.||.   ..|| ||   .     | ||||.|.  |   |. |||. | .  .   ||||.|  .   ||| | ..|  . || .|||      .|  
nryanivtydhsrvvleklsn..dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst...sk..

gdriYGHISVAVCSGEQHPGYILTHIRL-RKG-KEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEeQRQGPPIVHCSAGIGRTGTFIAIDQA
    |  . |..   |    ||.  . . . |  ||. . .| |  |||.|||    |  |. . ...          | ..|||||.||||.|. ||  
....ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy..atavlglrrkitkdsl.pgarpwvihcsagvgrtgaflvidam

VRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.|  ..   || .. |  .|. |  |||  .|| ||
lrqakkqktvdifnyvkairedrphmvqtseqyvfi
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1-234 2.3e-37 123.3 In-house 49-228 (392) alignment 
Range on Protein: 1-234
Range on HMM: 49-228/392.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGrvkcarywptvryneakkv
||| ||||  ..||.||   .  .. | |.|| || .. .. . |||. ||   ... |||||.  .  .|.| | . |                     
nryknilpydsarvklevidd..ipdsdylnasyipsfdne.kayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...................

gdriyghisvavcsgeqhpgyilthirlrKGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEeQRQGPPIVHCSAGIGRTGTFIAIDQAVR
                             ||.. .    . | .|||..||    .  .. ....|.|    |   | |.|||||.||||  |.||  | 
.............................kgddartvaqfhftewPdkdvpkh..tssllkfikevkadfG.qythpliihcsagvgrtgvvisidsvva

CLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
  ..|  || ...|.|.|..|  |||  .|| ||
hakktrmvdvfnfvtnirrkrpymvqtkeqyafi
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1-234 1.2e-36 121.2 In-house 45-269 (307) alignment 
Range on Protein: 1-234
Range on HMM: 45-269/307.0
NRYTNILPNPRTRVRLEDEyepwTSVSTYINANYIaGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAkkV
|||...    ..|. .. .       | || |||. | . .|. .|.| |||.||.  || |.   |  ...|   ..| ...|| .||| .. ..   |
nryqdvkcqdkgrivvkfd....glasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqkl..v

GDRIYGHISVAVC-SGEQHPG---YILTHIRLRKGKEEQLLRHYWFQNWPDHGVPSAEgaHQVIAMMQNVRafceeQRQGPPIVHCSAGIGRTGTFIAID
       ||||   ...  |      .| ...  ... . ..|. ..||||.|||  .     | ... ||       . | .||||||.||.|| .|| 
fgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqin..ltainlleavr.....ydtnpvvvhcsaGvGrsGtivais

QAV-RCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
    . ..     |  ..| ..|..|   .|   || ..
lvqdkmiaGinckdmkklveelrsqrhyaiqteaqylyl
subfamily_PTPRN_pd Subfamily PTPRN 1-234 1.9e-34 113.7 In-house 60-284 (297) alignment 
Range on Protein: 1-234
Range on HMM: 60-284/297.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPtvryNEakkv
||....||   .||.|..| .  .. | ||||  |     .   |||. ||| .|. .||.|||   .  ||. |.. |.|  .|.||||    .|    
nrskavlpydhsrvklkeeas..aeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywp....de....

GDRIYGHISVAVCSGEQH-PGYILTHIRLR--KGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAfCEEQRQGPPIVHCSAGIGRTGTFIAIDQ
|  .|.   | . |       |..  . |.  . .| . .  . |  ||..|||..  |. .. . . |   .   |  | .||||.| ||||..|.|| 
GsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPas..aksllefrrkvnk.syrGrscpivvhcsdGaGrtGvyilidl

AV-RCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 . | |    |.|    .  .|  | |.|.  .|.||.
vlnrllkGvkeidiaatlehlrdqrpglvktkdqfefa
subfamily_CG42327_pd Subfamily CG42327 1-168 2.1e-34 113.6 In-house 32-192 (319) alignment 
Range on Protein: 1-168
Range on HMM: 32-192/319.0
NRYTNILPNPRTRVRLEDEyePWTSVSTYINANYIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvrynEAKKV
.|. |..| | ||| |.    .    . |..|.|. || . |  ||||  .|...  .|||.||  .|  ||  | . |.|  .||.|.||    ..   
srvinvvPlPetrvvlqri..gdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPt....ketld

GDRIYGHISVAVCSGEQHPGYILTHIRLRK--GKEEQLLRHYWFqNWPDHGVPSAEGAhqVIAMMQNVRA
. . ||.| |..  .| .  |... . |..  ..| . | |||. .|.. .||. | |  .|||. .||.
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaa..liamllevrs
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1-234 3.3e-33 109.6 In-house 59-281 (305) alignment 
Range on Protein: 1-234
Range on HMM: 59-281/305.0
NRYTNILPNPRTRVRLEDeyePwtSVSTYINANYIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAKKV
|||...  . .. |.|..   |  | | || |||.       . .|.| ||||.||. || ||   |   |||    .| |..|||.|||. . .  .  
nryqdvpcqdqsavkldk...p..spsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelk

GDRIYGHISVAvCSGEQHPGYILTHIRLRK-GKEEQLLRHYWFQNWPDHGVPSAEGAhqVIAMMQNVRAfceeqRQGPPIVHCSAGIGRTGTFIAIDQAV
.  .   .| .    |. .   .| ..|   |...  .||  . .||| ||| .  .   . ..  .|       . | .|||||||||||| .||.  .
sgivvenvsgs.kpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppcklt..slellsairg.....skvpivvhcsagigrtgtivaieyil

RCLEETGEVDCL-QIVANMRKHRGGMVQHPQQYEFI
  . |  ..  . ..|  .| .|   .|   || ||
ekiaenkpcppmpelvkalrdqrafsiqndvqylfi
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1-234 1.1e-32 107.8 In-house 41-261 (281) alignment 
Range on Protein: 1-234
Range on HMM: 41-261/281.0
NRYTNILPNPRTRVRLEDEYePWTSVSTYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvrynEAKKV
|||.||     .||.|. .  |    . || ||||       | || . ||  .|   ||||.|  .. ||||   ..|  | ||| |.|     .|. .
nrylnipcldisrvqlkvkm.pnknstdyihanyirspf.lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfpr....nahcc

gdRIYGHISVAVCSGEQHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAfceeqRQGPPIVHCSAGIGRTGTFIAIDQAVR
    . ..||.          . |.. |    | .|. |. ...|||  || .  .  .. .....||     |  ||..|||||.||.||..|.. |..
..lqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpes..sevmlkilrkira.....rstppvihcsagvgrsgtlmaveialq

CLEETG-EVDCLQIVANMRK-HRGGMVQHPQQYEFI
 .       |  |||. .|   |   ||  ||| .|
sihshftlpdikqivshlrvtgraasvqtlqqymli
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1-234 5.4e-31 102.5 In-house 52-279 (305) alignment 
Range on Protein: 1-234
Range on HMM: 52-279/305.0
NRYTNILPNPRTRVRLEdeyEPWTsvSTYINANYIAGySSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNE--AK
||| ..    . ||.||    ||     || |||..   ..|. .| .  ||..|   || | .  |  || |   ..|.|  ||. |...   ..   .
nrykdvgcldnnrvkle...gpwp..heyihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefe

KVGDRIYGHISVAV-CSGEQHPGYIL--THIRL-RKGKEEQLLRHYWFQNWPDHGVPSAEGAhqVIAMMQNVRAfceeqRQGPPIVHCSAGIGRTGTFIA
. |..|  ..  .|  . ...    .  | . .   |.. .   || . .||| |||.|. |  .. .... |.      .|| .|||||||||||. . 
ekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadla..ilellekarp.....skgpivvhcsagigrtgsvvm

IDQAVRCLEETGEV-DCLQIVANMRKHRGGMVQHPQQYEFI
..  .  | .   . |. .|.  .|. |   .|  .|| |.
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfv
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1-233 4.4e-28 93.1 In-house 47-262 (288) alignment 
Range on Protein: 1-233
Range on HMM: 47-262/288.0
NRYTNILPNPRTRVRLEdeyepwTSVSTYINANYIAgYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRyNEAKKV
.||.|.     |||.|.           ||.|| ..  .  .|  | |  ||. ||| .|.|.       ||| . ..|.|. | | |.|..   |. ..
dryenlprcditrvkls......ddpdfyiaanvvs.sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl.Gekari

GDRiYGHISVAVcSGEQHpGYILTHIRL-RKGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVrafceEQRQGPPIVHCSAGIGRTGTFIAIDQAV
|      . .   .. ..    .. .|  ..|.|......  ...|.|.|||        . ... .     .. | | .||.|||.|||||.| |  |.
grl.ctvvkkkr.adidk.lvkvsllriskegeekvivkilhlleWdddgvPen..ylsplrllevl.....kslqkPivvhssaGvGrtgtlililial

RCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEF
. |  .  .   ...|..|..|   .|  .|| .
eslrlddflgirsllaklreerfkaiqtemqyly
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1-232 1.5e-26 87.8 In-house 47-266 (312) alignment 
Range on Protein: 1-232
Range on HMM: 47-266/312.0
NRYTNILPNPRTRVRLEDEYepwtsvSTYINANYIAgYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYnEAKKV
||| ||    | |  |  .         || ||..    ..|  .... |||.||.  ||...  . | .|.. . ..|.|  |||.|   .     .  
nrypniqcwdrgrftlagde......nfyihanfvk.ictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivg.fvdle

GDRIYGHI----SVAVCSGEQHPGYILTHIRLRKGKeEQLLRHYWFQNWPDHGVP-SAEGAHQVIAMMQnvrafceeQRQGPPIVHCSAGIGRTGTFIAI
  |.|        .   | ..    .|  .    |. |  | || .  |||||.| | . |..... ..        . . | | |||||.|||||.. |
dhrvyteycteieiggkskdkithrvlkvvvkatgq.esklnhyqwaswpdhgmpdscdtalrllsavk........kdkkpviahcsagvgrtgtlali

DQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYE
.  . .|      .  ..   .|| |   |.   || 
esmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyv
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1-233 9.3e-25 82.1 In-house 37-250 (267) alignment 
Range on Protein: 1-233
Range on HMM: 37-250/267.0
NRYTNILPNPRTRVRLEDEYEPwtsvstYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQgrvKCARYWPTvRYNEAKKV
||. . ||   ||| | .. |       |||| |. ||  . . .|.  .||.|||  |. ..   | | ||. |.  ..   .  ..||  .  .||| 
nrlddnlpyddtrvilrtkeee......yinasyvegyktk.nafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPP.kmgqakky

GDRIYGHisvAVCSGEQHPGYILTHIRLrKGKEEQLLRHYWFQNWPDHGVpsaegAHQVIAMMQNVRAFCEEQRQG-PPIVHCSAGIGRTGTFIAIDQAV
 |    |   ..   |.    |   ... | .  . .  |....|           .  .  .  . |  . .  . | .|.||.|.||.|||. ||  .
qdltveh...slekeendyqiitlelkf.knesahnvtlyyykkwnintn.....nkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsql

RCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEF
. . . | .|  . . ..|. | |.|.  ..| .
eraktegvsdifdflrkirsqriglvdtkeryiy
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1-97 2.5e-20 67.5 In-house 51-158 (350) alignment 
Range on Protein: 1-97
Range on HMM: 51-158/350.0
NRYTNILPNPRTRVRLE------DEYEPWTSVSTYINANYIAGY----SSQPRE-YIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYW
|||.||||  ..||.|.      |  .  .| . ||||||.       . .|   |||. .|| .|.. |....   | . |.. |. .|... || |||
nrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYW

PTVRYNEA
.   |.. 
qegsyddi
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1-96 3.4e-15 50.4 In-house 56-147 (310) alignment 
Range on Protein: 1-96
Range on HMM: 56-147/310.0
NRYTNILPNPRTRVRLEDEYepwTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNE
|||....    .||.|. .    .    || |||.     .   .| . |||. ||  ||||..  .. .|..   ..|.|| ||  |||..   |
nrysdvvcldtsrvklkidk...sryedyihanyvktnylr.stficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvte
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1-97 9e-11 35.7 In-house 52-161 (349) alignment 
Range on Protein: 1-97
Range on HMM: 52-161/349.0
NRYTNILPNPRTRVRLEDEYEPWTS------------VSTYINANYIAGYS-SQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCAR
||| .|||   .||.|.   ..  .            .  ||||||.     |  . ||| . ||  |.. |.... . . . ..  .   |..  || .
nrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdi

YWPTVRYNEA
||    |.. 
ywqelsysni
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2-233 7e-27 89.1 In-house 40-261 (285) alignment 
Range on Protein: 2-233
Range on HMM: 40-261/285.0
RYTNILPNPRTRVRLEDEYepwtsvSTYINANYIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvRYNEAKKVG
||...     ||| |..          || |...     .   ||.. ||| .|.  ||.|..  |   ..|   ..| |  ||| |.|  .  |  |.|
ryadvrcieetrvvlknhd......rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype.klgevvkfg

DriYgHISVAVCSGEQHPGYILTHIRLR---KGKEEQ-LLRHYWFQNWPDHGVPsaEGAHQVIAMMQNVRAFceEQRQGPPIVHCSAGIGRTGTFIAIDQ
   |  |... |  |   | ||  . .        |   . |     |||.  |  | |. .| . . |.    . .. |  ||||||.||| ||. || 
k..y.eitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlap..edarpmielykwvkkv..npkekpicvhcsagvgrtatfvgidy

AVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEF
|   . |  ... |.|| .||  |   ||   |. |
atirimenpniemldivremramrfqavqshmqflf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2-231 7.6e-27 88.8 In-house 55-270 (301) alignment 
Range on Protein: 2-231
Range on HMM: 55-270/301.0
RYTNILPNPRTRVRLEDEYEpwtsvSTYINANYIAGYsSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYnEAKKVG
|| ..  .| | |.. .. .        | ||.|     .|. .||. |||.|| | || |. . .   ||| .  .|.   ||. | |.    |  ..|
ryptvPckPstavevivdGk.....rvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis.ekldig

DRIYGHISVAVCSGEQHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVPSAEgaHQVIAMMQNVRafceeQRQGPPIVHCSAGIGRTGTFIAIDQAVRC
       .  .   ..     |      .  . . . || ...|.|.||| .    ..  .|. |.     . . | .|||||||||. .||. .   | 
rfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPksh..aelfdlmelvk.....ksekPivvhcsaGiGrsvafigteylare

LEETGEVDCLQIVANMRKHRGGMVQHPQQY
.|   ...  . ....|.||   ||. .| 
veadptieltealkhlrehrwngvqtnsql
subfamily_eak_pd Subfamily eak 5-205 3.3e-17 56.9 In-house 59-266 (332) alignment 
Range on Protein: 5-205
Range on HMM: 59-266/332.0
NILPNPRTRVRLEDEYepwTSVSTYINANyIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAKkvgdri
.|.|. |  |||            ||||  .| .|   |.|| .  . .. . |||.||   ||||||.    .|..  |  .|.|    .| |      
kivpydrylvrltssq...lnrlGyinas.laefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelk......

YGHISVAVCSGEQHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVPSAE------------GAHQVIAMMQNV-RAFCEEQRQGP----PIVHCSAGIG
.|.. |   .  ..  .    . |.|| |   . || .  | .  .|  |            |. ..| | ... ...       |    ||. .. |  
fGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsa

RTGTFIAIDQAVRCLEET
|.|.|. ||  .| ... 
raGvfvvidllirlidnk
subfamily_egg_pd Subfamily egg 12-234 2.9e-23 77.0 In-house 55-262 (307) alignment 
Range on Protein: 12-234
Range on HMM: 55-262/307.0
TRVRLedEYEPWTSVSTYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQgrVKCARYWPTVRYNEAKKVGDRIygHISVA
.||.|  |..    .  .| ||.. |      |.| |  || || . |||||.  . . ||| |   |    .|  |||    . .. |   .  .|   
srvkl..elrrGqylddfihanrvkGkp.llnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGsl..rienl

VCSGEQHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGvpsaeGAHQVIAMMQNVRafceeQRQGPPIVHCSAGIGRTGTFIAIDQAVRCLEE--TGEVD
    .  | . .|...|  |..|..   .|  ..   .       .  . ... .|     .   | .|..  |. ...|..||. |.  |    .    
kvdskadplfrvtklklvGgddeerflehwqgdvnnss.....dvysplrvlrklr.....nlskpvvvqdilGvskaatlvaieiallsllrGpitksl

CLQIVANMRKHRGGMVQHPQQYEFI
 |. |  .|..|   |. . .| |.
vlravvflrlrrrlsvesvllylfv
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 12-73 3.8e-08 27.2 In-house 52-115 (347) alignment 
Range on Protein: 12-73
Range on HMM: 52-115/347.0
TRVRLED---EYEPWTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVM
||| |     .  .   | ||||| .|    .. .||| .  || .|.  ||.|| ..|   .| 
trvvlspeksknsraddvetyinashikfdnas.keyiltqyplpdtvrdfwkmvsvtkvtqvvt
0044763 (Phosphotyrosine protein) phosphatases II 13-234 2.8e-29 97.4 In-house 4-163 (178) alignment 
Range on Protein: 13-234
Range on HMM: 4-163/178.0
RVRLEDEYEPWTSVSTYINANYIAGYssqprEYIAAMGPldntiEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYneakkvgdriyghisvav
| |   .  ...  | ||||..| ..      |... .|     ........  .  .||. |. .| |..|| .|||.                     
rtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..................

csgeqhpgyilthirlrkgkeeqllRHYWFQNWPDHGVPS-AEGAHQVIAMMQNVRafceEQRQGPPIVHCSAGIGRTGTFIAIDQAVRCleetgEVDCL
                          .| . ..||||||.  |  ...........    ....|| .||||||.||.||..|..   ..      ..  
.........................iqylhipipDhgvpdllehflefvefieeal....dekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsle

QIVANMRKHRGgMVQHPQQYEFI
.... .|..|  .|..| |....
eaielvrerRp.ivpnpgqlrqL
0051429 (Phosphotyrosine protein) phosphatases II 25-234 2e-43 144.3 In-house 2-217 (272) alignment 
Range on Protein: 25-234
Range on HMM: 2-217/272.0
SVSTYINANYIAGYsSQ---PREYIAAMGPLDNTIEAFWRMvWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNE----AKKVGDRIYGHISVAVCSGEQ
..|.||||... ||  .   |. .... |||..|.. |||. .  .  .||. .. .|.||.|| |||| .||         . .  ||...| . | |.
plsgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

HPGYILTHIRLR---KGKEEQLLRHYWFQNWPDHGVPSAEgAHQVIAMMQNvrafceeqrQGPPIVHCSAGIGRTGTFIAIDQAVRCLEETGEVD-----
.. |||....|.   . .|   ..|.....|||||||. .  .........         .|| .||||||..||||..|..  .. ....  ||     
lldyilrellltlllsagearevmhlhytdwpdhgvpqea.llellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

---CLQIVANMRKHRGGMVQHPQQYEFI
    ...|. .|..| |.||...||.|.
nlyleeaveelraqrpgavqteeqylfl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 25-232 1.2e-12 42.0 In-house 67-269 (303) alignment 
Range on Protein: 25-232
Range on HMM: 67-269/303.0
SVSTYINANYIAgYSSQPReYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPtvRYNEAKKVGDRIyghISVA-VCSGEQHPGYIL
| |.|| |.|.    |. .  | .  ||  |   ||.|.   |   ...     |  ..     .|  | ..  |  .|    | |      |   |. |
sdssyihasyle.ldsskk.ailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfp..rnqdflkfeers...irvgefkrvelgdgwvl

THIRLRKGKEEQLLRHYWFQNWPDHGVPSAeGAHQVIAMMQNVRAFCEEQRQGPPIVHCS-AGIGRTGTFIAIDQAVRCLE-ETGEVDCLQIVANMRKHR
  . . .|.   .|  . ...||   .||  |. ...  . .....     .. | |. | .| ||.|||  .. |   |  |   .| .. . |.|. |
kvlsvsngdyksflhvhhykawphnsipsd.gspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngr

GGMVQHPQQYE
   ||   |. 
lhavqnlsqfs
0046846 (Phosphotyrosine protein) phosphatases II 26-234 1.1e-38 128.1 In-house 11-165 (176) alignment 
Range on Protein: 26-234
Range on HMM: 11-165/176.0
VSTYINANYIAGYssqprEYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAkkvgdriyghisvavcsgeqhpgyilth
 ..|||||.|.|.      .||  ||| .|...|..|..  .  |.|. | ..| ||.||..||| .. ..                             
dldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

irlrkgkeeqllrHYWFQNWPDHGVPSAEGAHQVIAMMQNVRafcEEQrqGPPIVHCSAGIGRTGTFIAIDqavrcLEET-GEVDCLQIVANMRKHRG-G
             .|.. .|||||||. |  ...........   .|   || .||||||||||||..|..     | |.   .. ....| .|..|  |
.............qylhlpwpDhgvpdlelllellefireal...keg..gpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqRplg

MVQHPQQYEFI
.||.|.||.|.
avqtpeQyrfl
0051082 (Phosphotyrosine protein) phosphatases II 26-234 2.4e-29 97.3 In-house 2-145 (151) alignment 
Range on Protein: 26-234
Range on HMM: 2-145/151.0
VSTYINANYIAGYssqpreYIAAMGPLDntieAFWRMVWMVKSPAIVMTTPMMEQGrvKCARYWPTVRyneakkvgdriyghisvavcsgeqhpgyilth
.|.|||..|. |.      ...  |||.    .|.....  .  .||. .. .| |  .|..|.|                                   
lsdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

irlrkgkeeQLLRHYWFQNWPDHGVPSAegAhqviAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQAVRCleetgeVDCLQIVANMRKHRGGMV
           ..|... .|||.|.|         . ....  .......|| .||||||.|||||..|..   .       |.  .... .|..|.|.|
.........ievlhipildwpdpglpls..f....davleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvv

QHPQQYEFI
|..||. |.
qpnqqflfq
0036282 (Phosphotyrosine protein) phosphatases II 27-234 4.8e-41 135.7 In-house 2-162 (174) alignment 
Range on Protein: 27-234
Range on HMM: 2-162/174.0
STYINANYIAGYSSQPrEYIAAMGPLDntieaFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryneakkvgdriyghisvavcsgeqhpgyilthi
|.||||... ..   | ..||  |||.     ||.|..  .. ..|| .. .| |..|| .|||.                                   
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

rlRKGKEEQLLRHYWFQNWPDHGVPSAEGahqVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQAVRCLEeTGEVDCLQIVANMRKHRGGMVQ
  ..  .|.|  .|.. .|||||||. .    .. ... |. ...| ..|| .||||||.|||||..|..   |.|. .. || |..|. .|..|.||||
..lredlerlgiqylylpwpDhgvpdlsi...llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvq

HPQQYEFI
.|.||.|.
tpsQyrfl
0043147 (Phosphotyrosine protein) phosphatases II 27-234 3.1e-38 126.6 In-house 5-153 (172) alignment 
Range on Protein: 27-234
Range on HMM: 5-153/172.0
STYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMmeqgrvkcarywptvryneakkvgdriyghisvavcsgeqhpgyilthi
|.||||.|. .|   |...||  |||.||.. ||||..  .  .||. |.                                                  
sdyinasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

RLRKGKEEQLLRHYWFQNWPDHGVPSAEGAHQVIAMMQNVRafcEEQRQGPPIVHCSAGIGRTGTFIAIDQAVrcleetGEVDCLQIVANMRKHRGGMVQ
 . . ..|.|  .|.. .|||||||..|   ...  ....     ....|| .||||||.|||||..|..           .. ...|| .|..|.|.||
lydpellerlgiqylylpwpDhgvpllellleflefidell...alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavq

HPQQYEFI
.|.|| |.
npsqyrfl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 27-234 4.6e-18 60.4 In-house 46-251 (290) alignment 
Range on Protein: 27-234
Range on HMM: 46-251/290.0
STYINANYIAgYsSQPREYIAAMGPL-------DNTIEAFWRMVWMVKSPAIVMTTPMMEQGRV----KCARYWPTVRYNEAKkvgdriYGHISVAVCSG
. || ||..  . ..  . |.   |.       . ||| || |.   |.  .||.  ..|. .      ||.| |.   .| |      .. ..|  .| 
ddyiHAnrvt.c.pnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelk......fkgltvkCksk

EQHPGYILTHIRLRKGKEEQL-LRHYWFQNWPDHGVPsaEGAHQVIAMMQNVRafCeeqRQGPPIVHCSAGIGRTGTFIAIDQAVRCLE-ETGEVDCLQI
|.. . .  .. .. ..||.. . |.....| .  |.  |    .....|.|.  .   .. | ||||  || |  .. ||. .   .   .|.|   ..
ekeddvetRelvvkfddeeeftvtHsllkgWnklnvq..edtktllsliqkvk..a...sktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledv

VANMRKHRGGMVQHPQQYEFI
. ..||.|  ........ |.
lkalrkqralaitsalelafv
0049260 (Phosphotyrosine protein) phosphatases II 41-234 4.6e-36 119.2 In-house 7-142 (152) alignment 
Range on Protein: 41-234
Range on HMM: 7-142/152.0
QPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWptvryneakkvgdriyghisvavcsgeqhpgyilthirlrkgkeeqllrHY
.|.|.||. ||..||.. ||||..  .  .||| |  .| |..||..|.                                                 .|
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.................................................qy

WFQNWPDHGVPSAEGAHQVIAMMQNVRafcEEQRQGPPIVHCSAGIGRTGTFIAIDQAVrcleetGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 . .|||||||. .   . .  . . .    ....|| .||||||.|||||..|..           |. ...|| .|..| |.|..|.|..|.
lhlpwpDhgvpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 43-234 3.9e-25 83.2 In-house 5-196 (199) alignment 
Range on Protein: 43-234
Range on HMM: 5-196/199.0
REYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRyneakkVGDRIYGHISVAVCSGEQHPGYILTHIRLRKGK----EEQLLR
| |||.  || .|.  ||.|||   |  |||      .  .  . ||||.        |   || .||.. .   .| | .| . | .        . . 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywptte......sgtgkygslsvttktittkpdytitaliltnnttappstreis

HYWFQNWPDHGVPSAEGAHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQAVRCLEE--TGEVDCLQIVANMRKHRGGMVQHPQQYEFI
|| |  | ..  |        .   ..|    |.... | ||||| | | || |.|.|  ||  ||  |  || ...   .|. | |..   |.|.||
hyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 43-234 4.2e-25 83.1 In-house 4-195 (198) alignment 
Range on Protein: 43-234
Range on HMM: 4-195/198.0
REYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRyneakkVGDRIYGHISVAVCSGEQHPGYILTHIRLRKGK----EEQLLR
| |||.  || .|.  ||.|||   |  |||      .  .  . ||||.        |   || .||.. .   .| | .| . | .        . . 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywptte......sgtgkygslsvttktittkpdytitaliltnnttappstreis

HYWFQNWPDHGVPSAEGAHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQAVRCLEE--TGEVDCLQIVANMRKHRGGMVQHPQQYEFI
|| |  | ..  |        .   ..|    |.... | ||||| | | || |.|.|  ||  ||  |  || ...   .|. | |..   |.|.||
hyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 50-233 1.7e-18 61.1 In-house 98-279 (302) alignment 
Range on Protein: 50-233
Range on HMM: 98-279/302.0
GPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvRYNEAKKVGDRIYGHISVAVCSG--EQHPGYILTHIRLRKGK----EEQLLRHYWFQ
 |  .|.| .| ..   .   .|  . ..|..  ||| |. . . ..  | |      .||           .. |  . ..  |     .. .    | 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysd.kvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

NWPDHGVPSAegAHQVIAMMQnvraFCEEQRQGpPIVHCSAGIGRTGTFIAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEF
 ||||| |    |.. . ...    |||  ..   .||||||.|||||..||   .    .    | |.||  .|. | | ||. ||  .
awpdhGapke..aytaldilk....fcesykkn.vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy
subfamily_hpo-7_pd Subfamily hpo-7 52-233 3.3e-17 57.3 In-house 43-218 (263) alignment 
Range on Protein: 52-233
Range on HMM: 43-218/263.0
LDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryneaKKVGDRIYGHISVAvCSGEQHpGYILTHIRLRK----GKEEQLLRHYWFQNWPD
| .||..|.... . |.  .|| . . |.|..|| .|.|.      .| . ... ...|. ..  |.   .|  . | .     |. . ..|| .. |..
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPl......ekdekqklanvnvc.ttkvqs.dvllktlellstlgeKkkthtvkhysykgWie

HGVPSA-EGAHQVIAMMQNVRAFceeqrqgppIVHCSAGIGRTGTFIAIDQAVR----CLE--ETGEVDCLQIVANMRKHRGGMVQHPQQYEF
.  |   .   ... . .| .           .||||.||||.  |  .... .     |.  .|.|.| |... ..|..| . .. | |  |
kndpelareilnilkvarnsksl.........vvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 55-233 1e-19 65.7 In-house 40-212 (255) alignment 
Range on Protein: 55-233
Range on HMM: 40-212/255.0
TIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryneaKKVGDRIYGHISVAVCSgeQHPGYILT--HIRLR--KGKEEQLLRHYWFQNWPDHGV
|...|.... . |.  .|| . . |.|..|| .|.|.      .| . ... ...|..         .|   .| .   . |. . ..|| .. |...  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfpl......ekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWiekna

PsaEGAHQVIAMMQNVRafceEQRqgPPIVHCSAGIGRTGTFIAIDQAVR----CLE--ETGEVDCLQIVANMRKHRGGMVQHPQQYEF
|  | |...  ... ||    . .  . .||||.||||. .|. .. . .     |.  ||.|.| |... ..|..| . .. | |  |
P..elareilnilkvvr....dsk..svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf
0048076 (Phosphotyrosine protein) phosphatases II 129-234 6.3e-22 73.2 In-house 39-135 (145) alignment 
Range on Protein: 129-234
Range on HMM: 39-135/145.0
RKGKEEQLLRHYWFQNWPDHGVPSA-EGAHQVIAMMQNVRafcEEqrQGPPIVHCSAGIGRTGTFIAIDQAVRcleetGEVDCLQIVANMRKHRGGMVQH
 .  .|.|  .|.. .|||||||.  |   ..........   .|   || .||||||.|||||..|..   .       |.  .... .|..| |.|..
elellerlgiqylylpwpDhgvpdllellleflefieeal...ke..ggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpn

PQQYEFI
|.|..|.
pgqlrfl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 130-234 2.2e-22 74.0 In-house 84-186 (440) alignment 
Range on Protein: 130-234
Range on HMM: 84-186/440.0
KGKEEQLLRHYWFQNWPDHGVPSAEGahQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQ
.| | . |..| .| |||.|||   |   |. |.|.|    |.  .|| .|||||| ||||  ||.|  .|  . . ..| . .. .||. |  ||| |.
ngiesrtlkqyhyqgwpdkgvpkfag..pvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpe

QYEFI
|| |.
qyafv
0048179 (Phosphotyrosine protein) phosphatases II 135-234 2.3e-21 71.4 In-house 47-137 (144) alignment 
Range on Protein: 135-234
Range on HMM: 47-137/144.0
QLLRHYWFQNWPDHGVPSA-EGAHQVIAMMQNVRAfceeqRQGPPIVHCSAGIGRTGTFIAIDQAVrcleETGeVDCLQIVANMRKHRGGMVQHPQQYEF
.   .|.. .|||||||.  |   ...........     . || .||||||.|||||..|..  .    . | ..  ...| .|..| |.|..|.|..|
regiqylhlpwpDhgvpdllellleflefieeale.....eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrf

I
.
L
PTPc_DSPc_SM00012 137-234 3.9e-32 106.0 In-house 2-99 (105) alignment 
Range on Protein: 137-234
Range on HMM: 2-99/105.0
LRHYWFQNWPDHGVPSAEgaHQVIAMMQNVRAFCEEQR-QGPPIVHCSAGIGRTGTFIAIDQAVRCLEET-GEVDCLQIVANMRKHRGGMVQHPQQYEFI
..||.. .|||||||.    . .. ....|. . ...  ..| .||||||.||||||.|.| ... ||.. .||| .|||  .||.| ||||  .|| |.
vkhyhytgwpdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 137-234 1.7e-12 41.8 In-house 217-336 (350) alignment 
Range on Protein: 137-234
Range on HMM: 217-336/350.0
LRHYWFQNWPDHGV--------PSAEGAHQVIAmMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQAVR---CLEETG----EV-------DC-LQI
. .  ..||.| ..        .. |   ..|    . . . ...|. | .||||||.|||||....|. .     ||..     ..       |   .|
vyqlqvknWkDlslllnPesilqalevkndlid.dlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VANMRKHRGGMVQHPQQYEFI
| ..|| |  |||  .|. ||
vnelrkqrismvqnldqfifi
PTEN_1 137-194 1.8e-07 26.2 In-house 94-149 (196) alignment 
Range on Protein: 137-194
Range on HMM: 94-149/196.0
LRHYWFQNWPDHGVPSAEGAHQVIAMMQNVRAFCEEqrQGPPIVHCSAGIGRTGTFIA
   |.   ..|||.|| .  . ... . . .  ...  ..  .||| ||.||.|| .|
gveylhfpieDhgapslselfdicksfiewllsdpn..gnvVlVHCkaGlgRsGtvva
0038934 (Phosphotyrosine protein) phosphatases II 138-233 2.6e-11 39.0 In-house 81-168 (194) alignment 
Range on Protein: 138-233
Range on HMM: 81-168/194.0
RHYWFQnWPDH-GVPSAEGAHQVIAMMqnvRAFCEEQRQGPPIVHCSAGIGRTGTFIAidqavRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEF
... .. .||.  ||| |  .. . ..     | .|. .|   ||| ||.|||||..|     . | ..   .  . .| .|  |.|........| 
eylklp.fpddgtvPsleillrfldlv...deflnedpggvvaVHCkaGlgRtGtlva.....aYLiyrlgmsaeeAialfrekRpgaipnqdylea
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 140-234 3.1e-12 40.5 In-house 186-277 (302) alignment 
Range on Protein: 140-234
Range on HMM: 186-277/302.0
YWFQNWPDHGVPsaEGAHQVIAMMQNVraFC-EEQRQGPPIVHCSAGIGRTGTFIAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
| ..||... ||  .   ..|. ...|  |  ... . . ..    |.|| |.|..  .|| .|..  |.   .||...|. |  .|.  .|| ..
yvltnWkqkkvp..vkyaeliktaakv..fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvsl
subfamily_PTPDC1_pd Subfamily PTPDC1 140-233 4e-08 27.9 In-house 86-167 (182) alignment 
Range on Protein: 140-233
Range on HMM: 86-167/182.0
YWFqNWPDHGVPSAEGAHQVIAMMQNVrafCEEQRQGppiVHCSAGIGRTGTFIAIdqavrCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEF
| |  |.|.||.| | . ... ... .   ..|.. .   ||| || ||||  ||       |  . ...  . .  .|..|   .|  .| |.
ynf.gwkDygvasleriLdivkvvafa...lqegkva...vhChaGlGrtGvliac.....ylvyakrltaekaiklvrskrpksiqtreqvel
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 142-234 2.3e-13 44.4 In-house 197-282 (310) alignment 
Range on Protein: 142-234
Range on HMM: 197-282/310.0
FQNWPDHGVPSaEGAHQViamMQNVRAfceEQRQGPPIVHCSAGIGRTGTFIAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
. |||| |||  |  | |    | . |   . |.|| .||||||..|... .|.. ..  |..  .||  .......|.|   .| . || .|
wpnwpdrgvpd.ekchtv...pqrlla...qvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqylii
subfamily_PTEN_pd Subfamily PTEN 147-233 1.1e-07 27.0 In-house 89-171 (184) alignment 
Range on Protein: 147-233
Range on HMM: 89-171/184.0
DHGVPSAEgahQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQAVRCLEETGEvDCLQIVANMRKHRGGMVQHPQQYEF
||  |. |    . ......... ||...   .||| || ||||. |.     ..| |. | . |.. |..| . .  |. | |  .
Dhnppple...lleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekae.ealelfaeaRtknkkgvtiPsqrRY
subfamily_CDC14_pd Subfamily CDC14 161-230 9.4e-08 26.2 In-house 250-313 (328) alignment 
Range on Protein: 161-230
Range on HMM: 250-313/328.0
AMMQNVRAFCEEQrQGPPIVHCSAGIGRTGTFIAIdqavrCLEETGEVDCLQIVANMRKHRGGMVQHPQQ
|....  . .|.  .|  .||| ||.|||||.||       | .. ..   ...| .|  | |.|  |||
aivkkfleiaeka.eGaiavhCkaGLGrtGtLiac.....ylmkhyrftaaeaiawlricrPGsvigpqq
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 162-206 1.7e-08 28.2 In-house 252-296 (349) alignment 
Range on Protein: 162-206
Range on HMM: 252-296/349.0
MMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQAVRCLEETG
  .. | . ....  . .|||||| ||||... .|  .  || . 
ddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplq
subfamily_CG42327_pd Subfamily CG42327 172-234 1.1e-17 58.7 In-house 244-307 (319) alignment 
Range on Protein: 172-234
Range on HMM: 244-307/319.0
EQRQGPPIVHCSAGIGRTGTFIAIDQAVRCLEET-GEVDCLQIVANMRKHRGGMVQHPQQYEFI
...||| .|||| |.||||. || | |.| |||.   ||  |.|  .|. |.  |.  .|||||
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefi
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 179-234 8.6e-11 36.0 In-house 1-56 (69) alignment 
Range on Protein: 179-234
Range on HMM: 1-56/69.0
IVHCSAGIGRTGTFIAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.||||.| |||||||||   .  .     || .  |  ||| |  ||    .| ||
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfi
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 179-234 1.1e-10 35.7 In-house 2-57 (69) alignment 
Range on Protein: 179-234
Range on HMM: 2-57/69.0
IVHCSAGIGRTGTFIAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.||||.| |||||||||   .  .     || .  |  ||| |  ||   ..| ||
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifi