Gene MbrePTP-sf2-6 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily MbrePTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP044_AA protein Get Run
MbreP044_AA_175-409 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1-234 1.6e-104 343.7 In-house 24-256 (270) alignment
Range on Protein: 1-234
Range on HMM: 24-256/270.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvrynEAKKV
|||..|||.|.||||||.. |  .|...||||||..|.......||||||||..|...||||.|..|..||||||...|.|| ||.||||.    |.|. 
nRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa....epkek

GDRIYGHISVAVCSGEQHPGYILTHIRLR-KGKEEQLLrHYWFQNWPDHGVPSAEG----AHQVIAMMQNVRAFCEEQRQG-PPIVHCSAGIGRTGTFIA
 .  .|.|.|...| |.. |||||..||. ||.|..|. |.|...|||||||..|.    ..|...|...||....|.... | .||||||.|||||.||
vkledgkikvlalseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.|.|||.||||..||.|.|....||.|  .||||.||||.
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyefl

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1-234 9.6e-79 259.3 In-house 32-260 (274) alignment
Range on Protein: 1-234
Range on HMM: 32-260/274.0
NRYTNILPNPRTRVRLEDEYePWTSVSTYINANYIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPtvrynE--AK
|||..||||...|| || |  .  . |.||||||| ||. . . |.|. ||| ||.. ||||..  ... |||.| . |. . |||.|.|     .    
nryktilPnensrvlleses.sededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP.....daedy

KVGDRiYGHISVAVCSGEQHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEEQ--RQGPPIVHCSAGIGRTGTFIAID
.. .| ||.... | .  .. .| .... |.. ..|. . |||. .|||| .|    |.... ....|.   ||.  . .| .||||||||||| ||||.
eiser.ygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPdd..antlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

QAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 ||| |.|.. || |.||.|.| .||||||  .|||.|
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyeli

subfamily_PTPRD_pd Subfamily PTPRD 1-234 9.5e-77 253.9 In-house 52-273 (564) alignment
Range on Protein: 1-234
Range on HMM: 52-273/564.0
NRYTNILPNPRTRVRLEDeyEPWTSVSTYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRyNEAkkv
||| ||..  ..||.|.    .... | ||||..| ||  ....|||. ||| .||| ||||||  .|  ||| | . |.|.|||..|||. . .|    
NRyanivaYdhsRVvLsk..vegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tet...

gdriYGHISVAVCSGEQHPGYILTHIRLRKGK--EEQLLRHYWFQNWPDHGVPSAEgaHQVIAMMQNVRAFCeEQRQGPPIVHCSAGIGRTGTFIAIDQA
    ||.. | . . |.   |......|.| |  | .  |.. | .|||||||      ........|||   |. .|| .||||||.|||||||.||  
....ygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesa..tslLdlirkvraln.epdagPivVhCSaGVGRTGtfividam

VRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.. ..| . ||  |.|...||.|  ||| ..|| ||
lerikeektvDiyqyvkalrkqRnamVqteeQYiFi

0050432 (Phosphotyrosine protein) phosphatases II 1-234 2.7e-76 252.2 In-house 72-291 (308) alignment
Range on Protein: 1-234
Range on HMM: 72-291/308.0
NRYTNILPNPRTRVRLedeyepwTSVSTYINANYIAGYS-SQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNeakk
|||..|||. ..||.|        . |.||||.|. |||  .||..||. |||.||.| ||||||  ... ||| |  .| ||.|||.|||.   .    
NrykdilpydhsRVkl.......degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgg....

vGDRIYGHISVAVCSGEQHPGYILTHIRLRK--GKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCeeqRQGPPIVHCSAGIGRTGTFIAIDQ
 | ..||...| . | |....|......|..  ..|.  ..|... ||||||||.   . ....... || ..   ..|| .||||||.||||||||.| 
.gsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPps..peilldflelvrksl...pggpivVHCsaGvGRtGtfialdl

AVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
....||..|.|| ...|. .|..| |||| |.||.|.
lleqlekeggvdvfeavkklReqRpgmvqtpeqylfl

subfamily_PTPRB_pd Subfamily PTPRB 1-234 3.8e-76 250.9 In-house 55-277 (293) alignment
Range on Protein: 1-234
Range on HMM: 55-277/293.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSqPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVryneakkV
||||||||   .||.|..  .  .| | ||||||| ||.| |||.||. ||| .|.. ||||||  || .||| | ..|.|.||| .|||.         
nrytnilpydhsrvkLaalkd..esgsDYinanyipgyns.prefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad.......e

GDRIYGHISVAVCSGEQHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVPsaEGAHQVIAMMQNVRAFC-EEQRQGPPIVHCSAGIGRTGTFIAIDQAV
 . .||.|.| . . |.   ... .....|.|||. .|.| |. |||||||  | ..........||    ......| .||||||.||||||||.|. .
epvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvP..ektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrll

RCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
. .||.  || . |||..|..|  .||  .|| ||
qaieeedyvdifgivaelReeRnllvqtekqYifi

0051299 (Phosphotyrosine protein) phosphatases II 1-234 1.4e-74 246.5 In-house 53-278 (288) alignment
Range on Protein: 1-234
Range on HMM: 53-278/288.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQPReYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryneakkV
|||..|||. ..||.| .. .   . |.||||.|| || .. . .||. |||.||.| ||||||  ... ||| |. .| ||.|||.|||.         
nRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl........g

GDRIYGHISVAVCSGEQHPGYILTHIRLR------KGKEEQLLRHYWFQNWPDHGVPSaeGAHQVIAMMQNVRAFCEeQRQGPPIVHCSAGIGRTGTFIA
|  .||.|.|   | |....|........      ...|..  .|... ||||||||.   . ....... || ... ...|| .||||||.||||||||
gsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd..spellldflrlvrkala.sgggpvvVHCsaGvgRtgtfia

IDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.| ....||..|.|| |..|. .|..| |||| |.||.|.
ldllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfv

0046845 (Phosphotyrosine protein) phosphatases II 1-234 2.1e-74 245.8 In-house 32-266 (284) alignment
Range on Protein: 1-234
Range on HMM: 32-266/284.0
NRYTNILPNPRTRVRLEDEYEPwTSVSTYINANYIAGYS----SQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVryNE
|||..|||. ..||.|  . .  .. |.||||.|. ||.     .....||. |||.||.| ||||||  ... ||| |. .| ||.|||.|||.   .|
nRykdilpydhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple..ge

AKKVgdriyGHISVAVCSGEQHPGYILTHIRLRK---GKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEE-QRQGPPIVHCSAGIGRTGTF
 ..      |...| . | |....|......|..   ..|.  ..|... .|||||||.   . ....... || ..|.  ..|| .||||||.||||||
vlty.....gdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvpps..pedlleflrlvrellenlpgggpivVHCsaGvgRtGtf

IAIDQAVRCLEETG---EVDCLQIVANMRKHRGGMVQHPQQYEFI
||.| . ..||..|   .|| |..|. .|..| |||| ..||.|.
ialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfv

DSPc_SM00195 1-234 3.5e-72 238.2 In-house 30-254 (263) alignment
Range on Protein: 1-234
Range on HMM: 30-254/263.0
NRYTNILPNPRTRVRLEDEYEPwtSVSTYINANYIAGYsSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRyneakkV
|||.||||. .|||.|..| ..  . |.||||||| |. .....|||. |||..|.| ||||||  |.. |||.|  .|.|. ||.||||          
nRyknilpydhtrVklkkeekk..egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees......g

GDRIYGHISVAVCSGEQHP-GYILTHIRLRKGK--EEQLLRHYWFQNWPDHGVP-SAEGAHQVIAMMQNVRAFCeeqrQGPPIVHCSAGIGRTGTFIAID
|   .|.||| . . |...  .||....|.| .  |.. ...|...|||||||| |..   ... .... .       .|| .||||||.||||||..||
gketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts....sgpivVhCsaGvgRtgtfvtid

QAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 ... |||. .||. .|| ..||.| ||||  .|| ||
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfi

PTPc_SM00194 1-234 3.5e-72 238.2 In-house 30-254 (263) alignment
Range on Protein: 1-234
Range on HMM: 30-254/263.0
NRYTNILPNPRTRVRLEDEYEPwtSVSTYINANYIAGYsSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRyneakkV
|||.||||. .|||.|..| ..  . |.||||||| |. .....|||. |||..|.| ||||||  |.. |||.|  .|.|. ||.||||          
nRyknilpydhtrVklkkeekk..egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees......g

GDRIYGHISVAVCSGEQHP-GYILTHIRLRKGK--EEQLLRHYWFQNWPDHGVP-SAEGAHQVIAMMQNVRAFCeeqrQGPPIVHCSAGIGRTGTFIAID
|   .|.||| . . |...  .||....|.| .  |.. ...|...|||||||| |..   ... .... .       .|| .||||||.||||||..||
gketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts....sgpivVhCsaGvgRtgtfvtid

QAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 ... |||. .||. .|| ..||.| ||||  .|| ||
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfi

0039614 (Phosphotyrosine protein) phosphatases II 1-234 2.5e-71 235.9 In-house 60-281 (297) alignment
Range on Protein: 1-234
Range on HMM: 60-281/297.0
NRYTNILPNPRTRVRLEDEYEPwTSVSTYINANYIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRvKCARYWPTVRYneakkv
|||..|||....||.| .| .     |.||||.|. ||.  .|..||. |||..|.| ||||||  ....||| |. .| || |||.|||.         
nrykdilpydhsrvklkpedgv.dldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg......

gdrIYGHISVAVCSGEQHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVP-SAEGAHQVIAMMQNVRAFCeeQRQGPPIVHCSAGIGRTGTFIAIDQAV
    ||...| . . |...||...........|.  ..|... .||||||| |.|   ... ......| .  ...|| .||||||.||||||||.. ..
...tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael..pkggpvlVHCsaGvgRtGtfiaaylml

RCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
..||..|.|| |..|. .|..|.|.|| |.||.|.
eqlekeggvdvleavkelreqRpgavqtpsqyrfl

0040438 (Phosphotyrosine protein) phosphatases II 1-234 3.3e-71 235.5 In-house 47-268 (317) alignment
Range on Protein: 1-234
Range on HMM: 47-268/317.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQPReYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryNEAKKV
|||..|||....||.| .. .     |.||||.|. |.. ... .||. |||.||.| ||||||  ..  ||| |. .| ||.|||.|||.   .| ...
nrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl...getlty

gdriyGHISVAVCSGEQHPGYILTHIRLR--KGKEEQLLRHYWFQNWPDHGVP-SAEGAHQVIAMMQNVRAfceeQRQGPPIVHCSAGIGRTGTFIAIDQ
     |...| ..| |...|..|.....   ...|.  ..|... .||||||| | .   . . .......    ...|| .||||||.||||||||.. 
.....gdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale....dpggpvlVHCsaGvgRtGtfiaayl

AVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
....||..|.||  ..|. .|..|.|.|| |.||.|.
mleqlekeggvdveeavkelreqRpgavqtpeqyrfl

Y_phosphatase Protein-tyrosine phosphatase 1-234 1.3e-70 232.8 Pfam-A 5-229 (235) alignment
Range on Protein: 1-234
Range on HMM: 5-229/235.0
NRYTNILPNPRTRVRLEDEYEPWTsvstYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPtvryneAKKV
|||..|||  .|||.|... .|      ||||||. ||. .....||. |||..||| ||||||  |. .||| |  .|.||.|||.|||       .. 
nRykdilpydktrvklkgsegpsd....YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp......eeee

GDRIYGHISVAVC-SGE-QHPGYILTHIRLRKGKEEQ---LLRHYWFQNWPDHGVPsaEGAHQVIAMMQNVRAFCeEQRQGPPIVHCSAGIGRTGTFIAI
.   ||.|.| .  . . .. .|.|....|.| |||.    .......||||||||  | ..... ....|.    |...|| .||||||.||||||.|.
esltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp..espkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfval

DQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
| ....||...||| |||| ..||.| ||||  .||.|.
dilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl

Y_phosphatase Protein-tyrosine phosphatase 1-234 1.3e-70 232.8 In-house 5-229 (235) alignment
Range on Protein: 1-234
Range on HMM: 5-229/235.0
NRYTNILPNPRTRVRLEDEYEPWTsvstYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPtvryneAKKV
|||..|||  .|||.|... .|      ||||||. ||. .....||. |||..||| ||||||  |. .||| |  .|.||.|||.|||       .. 
nRykdilpydktrvklkgsegpsd....YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp......eeee

GDRIYGHISVAVC-SGE-QHPGYILTHIRLRKGKEEQ---LLRHYWFQNWPDHGVPsaEGAHQVIAMMQNVRAFCeEQRQGPPIVHCSAGIGRTGTFIAI
.   ||.|.| .  . . .. .|.|....|.| |||.    .......||||||||  | ..... ....|.    |...|| .||||||.||||||.|.
esltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp..espkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfval

DQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
| ....||...||| |||| ..||.| ||||  .||.|.
dilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl

0036941 (Phosphotyrosine protein) phosphatases II 1-234 3.5e-70 232.0 In-house 43-269 (297) alignment
Range on Protein: 1-234
Range on HMM: 43-269/297.0
NRYTNILPNPRTRVRLEDEYepwtsvSTYINANYIAGYsSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAKkv
|||..|||...|||.|.||       | ||||.|. || ...|..||. |||.||.| ||||||  ... ||| |. .| ||.|||.|||.   .. .  
nRykdilpydhtRVklddeg......sdYinAsyvdgy.dlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegeslt..

gdriYGHISVAVCSGEQ--HPGYILTHIRLRK--GKEEQLLRHYWFQNWPDHGVPS-AEGAHQVIAMMQNVRafcEEQ-RQGPPIVHCSAGIGRTGTFIA
    ||...| . | |.  ...|.|..... .  ..|.  ..|... .|||||||. ..   . | ....|.   ..  ..|| .||||||.||.|||||
....ygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl...kllpsggpvlVHCsaGvgRsgtfia

IDQAVRCLE---ETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.| ....||   ..|.|| |..|  .|..| |.|| ..||.|.
adlmlqqledklkeggvdileavkklReqRpgavqtleqyrfl

0047943 (Phosphotyrosine protein) phosphatases II 1-234 4e-70 231.7 In-house 42-264 (273) alignment
Range on Protein: 1-234
Range on HMM: 42-264/273.0
NRYTNILPNPRTRVRLedeyE--PwtsvSTYINANYIAGYSSQPReYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVryneak
|||..|||. ..||.|    .  .    | ||||.|. || .... .||. |||.||.| ||||||  ... ||| |. .| ||.|||.|||.       
nrykdilpydhsrvkl....gdgg....sdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwple......

kVG--DRIYGHISVAVCSGEQHPGYILTHIRLRK--GKEEQLLRHYWFQNWPDHGVP-SAEGAHQVIAMMQNVRAFCEEQrqGPPIVHCSAGIGRTGTFI
 .|    .||...| . | |....|......|..   .|.   .|... .||||||| | |   . | ....... . ..  || .||||||.|||||||
.ggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn..gpvvVHCsaGvgRtgtfi

AIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
|.| ....||..|.|| |..|. .|..| |||| |.||.|.
aldllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl

0045450 (Phosphotyrosine protein) phosphatases II 1-234 1.4e-68 227.3 In-house 59-296 (307) alignment
Range on Protein: 1-234
Range on HMM: 59-296/307.0
NRYTNILPNPRTRVRLEDEYEPwTSVSTYINANYI--------AGYSSqPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTV
|||..|||...|||.| .. .   . | ||||.|.         || . .|..||. |||..|.| ||||.|  .. .||| |. .| ||.|||.|||. 
nrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde

ryNEAKKVGDriyghISVAVCSGEQHPGYILTHIRLR---KGKEEQLLRHYWFQNWPDHGVPSaeGAHQVIAMMQNVRAFCEEQ-RQGPPIVHCSAGIGR
  .| .  |.     . | . | |...||.......    . .|.  ..|... .|||||||.     ....... ||...||  ..|| .||||||.||
..geeltygn.....ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp..sfeelldfieevrkaleelpkggpvlVHCsaGvgR

TGTFIAIDQAVRCLEETGE---VDCLQIVANMRKHRGGMVQHPQQYEFI
||||||.. . |.||..|.   || |..|. .|..|.|.|| |.||.|.
tGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfl

0043336 (Phosphotyrosine protein) phosphatases II 1-234 2.8e-68 225.7 In-house 49-269 (278) alignment
Range on Protein: 1-234
Range on HMM: 49-269/278.0
NRYTNILPNPRTRVRLEDeyEPWTSVSTYINANYIAGYSSQPReYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPtvryneakkV
|||..|||....||.|..  ..    |.||||.|. ||. ... .||. |||..|.| ||||||  ... ||| |. .| ||||||.|||          
nrykdilpydhsrvklsl..lggdldsdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.........g

GDRIYGHISVAVCSGEQHPGYILTHIRLR--KGKEEQLLRHYWFQNWPDHGVPSaeGAHQVIAMMQNVRAFCEeQRQGPPIVHCSAGIGRTGTFIAIDQA
|   ||...| . . |....|.......   . .|..  .||.. .|||||||.     ... ... || ..|  ..|| .||||||.||||||||.. .
gsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe..slsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyll

VRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
...|| .|.|| ...|. .|..|.|.|| |.||.|.
leqlekeggvdleeavkelreqRpgavqtpsqyrfl

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1-234 3.9e-67 221.6 In-house 50-272 (318) alignment
Range on Protein: 1-234
Range on HMM: 50-272/318.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryneakkV
|||.|||.  .|||.|..  .  .  | ||||||| || .. ..|||| .|| .||| ||||||  .|  ||| | ..|.|..|..||||          
nryanilaydhtrvkLqmleg..eegsDyinanyidGyrrk.kayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPs........k

GDRIYGHISVAVCSGEQHPGYILTHIRLRKGK--EEQLLRHYWFQNWPDHGVPSAEgaHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQA
| | ||.. | . .  .   |.| ...... .  |..  | | . .|||.|||.     ........|..  ... .|| .||||||.||||.|||.|  
gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg..aslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdil

VRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.. ... . || .|.| ..|..|  |||  .|||||
lerikaealvDvfqtvkqlreqrnlmvqtedqyefi

subfamily_PTPN6_pd Subfamily PTPN6 1-234 1.9e-66 219.1 In-house 58-289 (306) alignment
Range on Protein: 1-234
Range on HMM: 58-289/306.0
NRYTNILPNPRTRVRLEdeyEPWTSVSTYINANYIAGY-SSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEakk
||| ||||   ||| |.   || .. |.||||||| .   .. ..|||. | |..|.. ||||||  .|  |||||  .|.|. |||||||..  .|   
nryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeeke...

vgdRiYGHISVAVCSGEQHPGYILTHIRLR---KGKEEQLLRHYWFQNWPDHGVPSAEGahQVIAMMQNVRAFCEEQR---QGPPIVHCSAGIGRTGTFI
   . ||.|||  .| ...  ||| ....    |.|||. ...| |..|||||||.  |  .|......|..  || .   .|| .||||||||||||||
...e.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpg..avLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfi

AIDQAVRCLEETG---EVDCLQIVANMRKHRGGMVQHPQQYEFI
 ||  .. .|..|   ..|  ..|  .|..| |.||  ||| |.
viDillkliekkgldadidiqklvksvreqrsglvqteqqykfv

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-234 7.3e-66 217.4 In-house 52-275 (319) alignment
Range on Protein: 1-234
Range on HMM: 52-275/319.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEakkv
|||.|||.  |||| | .  .  .  |.||||..| ||  . ...||...||.|||| ||||||  .|  .|| | . |...||. .|||.  ..|    
nryqnilaydrtrvvlseldg..vegsdyinasfidgyqer.ekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfee....

gdriYGHISVAVCSGEQHPGYILTHIRLRKGKEEQ---LLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQ
    ||.. | . . |.  .||  .. |.| ..|     . |. ...||||.||    | .........|   |.. .|| .||||||.|||||||..| 
....yGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPek..atslldllkrirksrektqsgPivvhCsaGvGRtGtfivlda

AVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
..  ..| | .|  ..| ..|  |  |||.|.||.||
mlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfi

0045098 (Phosphotyrosine protein) phosphatases II 1-234 1.4e-65 216.8 In-house 37-264 (278) alignment
Range on Protein: 1-234
Range on HMM: 37-264/278.0
NRYTNILPNPRTRVRledeyepwtsvsTYINANYIAGYssqPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryNEAKKV
|||..|||....||.             ||||.|| ||   |...||. |||..|...||||.|  ....||| |. .| ||.|||.|||    .. .  
nRykdilpydhsrVk............dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe...ggslty

gdriyGHISVAVCSGEQHPGYILTHIRLR------KGKEEQLLRHYWFQNWPDHGVPSAEGAHQVIAMMQNVRAFCE------------EQRQGPPIVHC
     |...| . | |... |.|......      .. |.  ..|... .|||||||| .   ... ... .|....            ....|| .|||
.....gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC

SAGIGRTGTFIAIDQAVRCLeEtGEVDCLQIVANMRKHRGG-MVQHPQQYEFI
|||.|||||..|..   ..| | | || |..|. .|..|.| .||...||.|.
saGvgRtGtlvaaylmlell.e.ggvdlleavkelrsqRpglavqnleqyrfl

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1-234 8.7e-65 213.6 In-house 45-268 (281) alignment
Range on Protein: 1-234
Range on HMM: 45-268/281.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYneakkv
|||.||     |||..... |  .. . |||||...||. ...||||. ||. ....|||.|||  |  |||| |  .|.|..|| ||||  .       
nrYsnivaYDatrvkvtpnee..nkntDYinanfvpgyk.gekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddns......

gDRIYGHISVAVCSGEQHPGYILTHIRL-RKGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQAV
 . .||.. |   . |... ||  ...| |.. |.. ...  ...|||||||.   .....   ..|. . |.... | ..|||||.|||||.||.|..|
.elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPat..tkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlv

RCL-EETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
. . .|. |.|  ..||..||.|  |||   ||||.
kaveaeleeldvkavvaelrkernlmvqtvvqyefv

0042113 (Phosphotyrosine protein) phosphatases II 1-234 2.2e-64 212.5 In-house 13-235 (245) alignment
Range on Protein: 1-234
Range on HMM: 13-235/245.0
NRYTNILPNPRTRVRLEdeYEPWTSVSTYINANYIAGYSSQPReYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryNEAKKV
|||..|||...|||.|    ...  .|.||||.|. ||   |. .||. |||..|.|.||||.|  .. .||| |. .| ||||||.|||.   .| ...
nrysdilpydhtrvkls..pdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl...geslty

GDriyghISVAVCSGEQHPGYILTHIRLR--KGKEEQLLRHYWFQNWPDHGVPS-AEGAHQVIAMMQNVRAFceeQRQGPPIVHCSAGIGRTGTFIAIDQ
||     ..| . | |....|.......   . .|..  .||.. .|||||||.  |   ... ......|     ..|| .||||||.||||||||.. 
gd.....ftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae...dsngpvlVHCsaGvgRtGtfiaayl

AVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
....||....|.  ..|. .|..|.|.|| |.||.|.
mleqlekelgvsleeavkelrsqRpgavqtpsqyrfl

0040439 (Phosphotyrosine protein) phosphatases II 1-234 3.8e-64 212.0 In-house 15-238 (249) alignment
Range on Protein: 1-234
Range on HMM: 15-238/249.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQPReYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryNEAKKV
|||..|||....||.|..  .     | ||||.|| || ...| .||. |||..|.|.||||.|  .. .||| |. .| ||.|||.|||.   .. ...
nrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl...ggsley

gdriyGHISVAVCSGEQHPGYILTHIRLR--KGKEEQLLRHYWFQNWPDHGVP-SAEGAHQVIAMMQNVRAFCeeQRQGPPIVHCSAGIGRTGTFIAIDQ
     |...| . | |....|......|   . .|.   .|... .||||||| | | . . | ....... .   ..|| .||||||.||||||||.. 
.....gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel..pkggpvlVHCsaGvgRtGtfiaayl

AVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
....||....|| ...|. .|..|.|.|| |.||.|.
mleqlekelgvdleeavkllrsqRpgavqnpeqyrfl

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1-234 2.1e-63 209.1 In-house 51-271 (288) alignment
Range on Protein: 1-234
Range on HMM: 51-271/288.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRynEakkv
||| ||||   .||.|..  |  .. . ||||.||.|. .. ..|||. ||| .|.. ||..|.  |.  ||| | ..|.|. || .|||.    .    
nRyrnilpyDekrvklkklee..eagaDYinasyidgekkk.kkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdad..k....

gDRIYGHISVAVCSGEQHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEEQrQGPPIVHCSAGIGRTGTFIAIDQAVR
  . ||.. | . . ..   ..| .. | | |.|  . .| .. ||||||| .  ..........|    ... .|| |||||||.||||||||.|... 
.pknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPes..kapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalid

CLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 .||.  .| . .||..||.|  .||  .|||||
aveeedyiDvagtvaklRkqRallvqtlkqYefi

0037934 (Phosphotyrosine protein) phosphatases II 1-234 2e-60 199.7 In-house 14-234 (243) alignment
Range on Protein: 1-234
Range on HMM: 14-234/243.0
NRYTNILPNPRTRVRLedeyEPwtsvSTYINANYIAGYssqPReYIAAMGPLDNTIEA----FWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPtvryne
|||..|||....||.|    |.    | |||||.| ..   || .||  |||..|.|     ||||.|  .. .||| |. .| ||.|||.|||      
nrysdilpydhsrvkl....eg....sdyinanliyvt...pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp......

akkvGDRIYGHISVAVCSGEQHPGYILTHIRLRK---GKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEE-------QRQGPPIVHCSAGI
    |.  ||...| . | |....|......|.    .....| .||.. .|||||||.     ....... ||.|.||        ..|| .||||||.
....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPds..pedlldfldevrefieellsllaldsggpvlVHCsaGv

GRTGTFIAIDQAVRCLeetgEVDCLQIVANMRKHRGG-MVQHPQQYEFI
|||||.||..   ..|    .|| ...|. .|..|.| .|| |.||.|.
gRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrfl

subfamily_PTPN12_pd Subfamily PTPN12 1-234 2.4e-60 198.9 In-house 44-269 (290) alignment
Range on Protein: 1-234
Range on HMM: 44-269/290.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSqPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAKkv
||| .|||   .|| |. . |  .  | |||||.| | .. . ||||| ||| .|.. ||||.| ..   .||   ..| |. ||.||||    .| .  
nrykDilPydksrvelskiee..eegsdYinanfikgveg.kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeele..

gdriYGHISVAVCSGEQHP-GYILTHIRLRKGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEeQRQGPPIVHCSAGIGRTGTFIAIDQAV
    .|...| . . ..   ....  ..... ||.. .. . ...||||||||.  |.........|| . | . . | .||||||.||||| |||| . 
....fgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPss..aksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvr

RCLEETG---EVDCLQIVANMRKHRGGMVQHPQQYEFI
. |..     |.|  ..|...||.|  .||  .|||..
ellkaekipeeldvfdlvlelrkqraalvqtkeqyelv

subfamily_PTPN9_pd Subfamily PTPN9 1-233 2.9e-60 198.8 In-house 46-281 (297) alignment
Range on Protein: 1-233
Range on HMM: 46-281/297.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAKkv
||||..|   .||| |. . |  .. | |||||.. ||  |.. .||. |||..|.. ||||||  .   ||||| ..|.||.||..|||. . . |.  
nrytdvlcydetrvvlakvde..deasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessae..

gdriYGHISVAVCSGEQHPGYILTHIRLR--KGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAF-----------CEEQRQGPPI-VHCSAGI
    .|..||.. . |..  |  . . ..  | .|.. . |. |  |||.||||.  |.... ....||              . . .|||| |||||||
....fgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPss..aaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGi

GRTGTFIAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEF
|||||||..| ..  |||.| ||  . |  .|. |  ..| |.||||
GrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyef

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1-234 8.6e-60 197.5 In-house 60-282 (298) alignment
Range on Protein: 1-234
Range on HMM: 60-282/298.0
NRYTNILPNPRTRVRLEDEYepWTSVSTYINANYIAGYSSQPrEYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVryneakkv
|||..|..   .||.||.|       |.|||| .. .|. ..  .||. .|| .|.| |||||.  .. .||| |.. |....|. .|||..        
NRyadiialdssRvvLeked..adeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPde........

GDRIYGHISVAVCSGEQHPGYILTHIRLRKGK--EEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQA
| . ||.|.| . | |..  .| ... . | |  .|. .|.  | .|||.|||.   |. |......|||  ..  . | ||.||||.||.|||||||  
gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpen..atsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsv

VRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.  ...   || .|.|  .||.| |.||  .|| ||
lervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfi

subfamily_PTPN3_pd Subfamily PTPN3 1-234 1e-57 190.2 In-house 45-267 (280) alignment
Range on Protein: 1-234
Range on HMM: 45-267/280.0
NRYTNILPNPRTRVRLEDeyepwtSVSTYINANYIAGYS---SQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvrYNEA
||| .|||   |||.|..      | . ||||||.   .   ..   |||. |||..| . ||.|||  ||  ||| | ..|.||||| .|||.   .. 
nryrdilpydatrvklke......setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe..tede

KKvgdriYGHISVAVCSGEQHPGYILTHIRLRKGK--EEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFcEEQRQGPPIVHCSAGIGRTGTFIAI
 .     ||..|| . . ...  |.| .. |.. .  ||. . .  . .|||||||.   ..... ....||.   . .. | .||||||||||| .|..
le.....ygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPdd..sadflefvervrkl.rsgkeePvvvhCsaGigrtGvlill

DQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
. |.  .|.. .|  |.|| .||  |. .|| ..||.|.
etalalieaaepvypldivrtmrdqramlvqtasqykfv

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1-234 8.2e-57 187.3 In-house 13-234 (250) alignment
Range on Protein: 1-234
Range on HMM: 13-234/250.0
NRYTNILPNPRTRVRLEDEYepWTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVkCARYWPTvrynEakkv
|||..|..   .|| || |       | |||| .. ||. . . .||. ||| .||| |||||.  || .||| | . |.... . .|||.    |    
nryadiialdssrvvLekek..gdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv....e....

GDRIYGHISVAVCSGEQHPGYILTHIRLRKGKEEQL--LRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQA
. ..||.. | . | |..  |. ... | | |...   .|.. | .||| |||    |. |......|.|  ..  ..| ||.||||.||.|.|||||  
kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPev..atavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

VRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.  |..   ||  ...  .||.| ..|.  .|| |.
lerlkkekvvdvfkvikvlrkdrphavesleqyvfv

subfamily_PTPN13_pd Subfamily PTPN13 1-234 8.7e-57 187.5 In-house 41-261 (273) alignment
Range on Protein: 1-234
Range on HMM: 41-261/273.0
NRYTNILPNPRTRVRLEDEYEpwtsvstYINANYIAGY-SSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRyNEAKK
||| |.||  .|||.|.||         ||||..|      .  ||||. ||| .|.. ||.|||  |.  |.| |   |.|.||| ||||  . |.  |
nryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesk.nkklk

vgdrIYGHISVAVCSGEQHPGYILTHIRLRKG--KEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEeqRQGPPIVHCSAGIGRTGTFIAIDQ
    ... . |..   ... |. . .. ...   .| . . |  | .||||||||.  | ... ....|| . .   .|| .|||||||||.||.|.|| 
....vsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPss..aaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidv

AVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
..  .|   |.|  .|| ..|. | |.||  .|| |.
vlglierdkefdvkeivrklreqrqgvvqtkdqyifv

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1-234 1.7e-56 186.6 In-house 50-275 (305) alignment
Range on Protein: 1-234
Range on HMM: 50-275/305.0
NRYTNILPNPRTRVRLEDEYEPWtsVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAKkv
||...| . .  |..|  . .     | ||||.|. ||...  .||.| |||.||.. |||... .|   ||| | ..|.|. || .|||.   .. .  
nrlkeitlldddriiltekesld..dsdyinasyvdgykrk.kkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekke..

gdriYGHISVAVCSGEQHPGYILTHIRLRK---GKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQ
    .|..|| . | .. ..||  .... .    ||.. . .| . .|||||||    |  .. ....|.   ..... | .||||||.||||.|||.| 
....fgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqf..atsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdi

AVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
|.  |.. ..||  ... ..|..| .|||  .|| |.
alerlkkEevvdvfevlkqlRskrmkmvqtldqYvfl

subfamily_PTPRK_pd Subfamily PTPRK 1-234 3e-56 185.5 In-house 47-269 (314) alignment
Range on Protein: 1-234
Range on HMM: 47-269/314.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPtvrynEAkkv
||...||.  |.||.|    .   . | ||||..| .|  .|...|.. |||..|.. |||.|.  .. .||| | ..|.||||| .|||     |    
nrsgdilaydrsrvflitidg..dpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP.....ed...

GDRiYGHISVAVCSGEQHPGYILTHIRLRK----GKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEEqRQGPPIVHCSAGIGRTGTFIAID
..  ||.| | . . | .  ..    |..|     .| ...|.. | .||||.||    |. .......| .  || ..|. .|||||| ||||||||||
tev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvs..atgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaid

QAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
  .  .|. | ||  ..| ..|...  ||.  .|| ||
ivldmieregvvdvfnavktlrsrkvnmveteeqykfi

subfamily_PTPRA_pd Subfamily PTPRA 1-234 5.9e-56 184.7 In-house 62-287 (330) alignment
Range on Protein: 1-234
Range on HMM: 62-287/330.0
NRYTNILPNPRTRVRLEDEYepWTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvrynEakkv
||. ||||.  .|| |       .  | |||| .| ||  .  ..||| ||...|.| ||||.|  || .||| | . |. . |||.|||.    |    
nrvvnilPydfsrvilsvke..GveesdyinasfidGykek.dkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd....e....

GDRIYGHISVAVCSGEQHPGYILTHIRLR------KGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAfCEEQRQGPPIVHCSAGIGRTGTFIA
|   ||.| |.|   .    | . .. ..      . |...|.| . |. ||| |||.   .  .. ....|.. ...|  || .||||||.|||||||.
GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe..piGmlkllkkvkk.lnqqsagpivvhcsaGvGrtGtfiv

IDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.|. .  ..  . ||  ..| ..|. |  |||  .|||||
ldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefi

subfamily_PTPRG_pd Subfamily PTPRG 1-234 2.6e-55 182.7 In-house 51-279 (563) alignment
Range on Protein: 1-234
Range on HMM: 51-279/563.0
NRYTNILPNPRTRVRLEDEYEPWTSVsTYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryNEAKKV
|||.||..  |.||.|..  .   .   ||||||| ||  . ...||. ||| .|.. ||||.|  ..  ||| | . |.|| || .|||.   .|....
nRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyq.kskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk...desety

GDRIYGHISVAVCSGEQHPGYILTHIRLRKGKE---EQLLRHYWFQNWPDHGVPSAEgAHQVIAMMQNvrAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQ
|      |.  | .  .    .. ...|.|.|.   |.| |.| . .|||||||. . . ..| . ..  .  ...  || .||||||.|||||.|..| 
galqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehs.lpvLifvkks..saankaeaGPivvHcsaGvgrtGtyivldt

AVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 .. ...   |. ....  .| .|  .||   || |.
llkqiqqenavnvfgflkhiraqRnflvqteEqYifl

subfamily_Ptp69D_pd Subfamily Ptp69D 1-234 1.3e-54 180.4 In-house 52-278 (307) alignment
Range on Protein: 1-234
Range on HMM: 52-278/307.0
NRYTNILPNPRTRVRLEDEyePWTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVryneakkv
||| .| .  .|||.|.    . .  |.||||..| ||  . ...||| .|...||. ||||..  ..  ||| . . |. | |||.|||          
nRyedikafDktRvkLkki..ngkedsdYinasfikgykek.kkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie........

GDRIYGHISVAVCSGEQHPGYILTHIRLRKGK-------EEQLLRHYWFQNWPDHGVPsaEGAHQVIAMMQNVRAFCEEQrQGPPIVHCSAGIGRTGTFI
    ||.| | . | |.|. ||  .. . | |       ... .  | ...|.|  ||  | |. .. ....||   . . ..| .|||||| ||.|.|.
devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvP..evargllklieqvrelykln.rsPivvhCsaGvgrsgifv

AIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
|.|  .  |..  .||  ..| ..|..|  .||  .||.|.
aldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvfl

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1-234 3.8e-53 175.4 In-house 48-269 (315) alignment
Range on Protein: 1-234
Range on HMM: 48-269/315.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryNEAKKV
||| ||||  ..||.||   .  .  | |||| || .. .. . |||. |||. ... |||||.  |  .||| | . |. ..||..|||    ..|. |
nryknilPldsarvklevidd..sPdsdyinasyiksvddd.kayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPd...rkadsv

GdriYGHISVAVCSGEQHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVPSAEGahQVIAMMQNVRAFcEEQRQGPPIVHCSAGIGRTGTFIAIDQAVR
    .| |.|.. | |.  . .  .. .||..| . .  . |..|||.||.   .   .. ....|.|  ..... . .||||||.|||| .|.||. | 
e...fGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqts..sllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevva

CLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 ...|  || ...| |.|..|  .||  ..| ||
qikrtrsvdvfnfvknlrakrpylvqteeeyafi

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1-234 4.4e-53 175.3 In-house 55-276 (297) alignment
Range on Protein: 1-234
Range on HMM: 55-276/297.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSqprEYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRvKCARYWPTVRYNEakkv
.||.||||  . ||.|.   .     | |.|| .. |.     ..|.   | ..|.. ||.||.  .  .||| .   |. . ||||||.    ..    
sRYkniLPydssRvkLaivnd..dpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt....

gdriYGHISVAVCSGEQHPGYILTHIRLRKGK--EEQLLRHYWFQNWPDHGVPSAEGAHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQA
    .|..|| . | ..  |.|  .. ..|||   ..... | | .|||. |.  . |.... ....||   ... .|| .|||.||.|||| ...||. 
....fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsv

VRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
|   ... ||| ...|  .|..|  .||  .||.|.
vaeakrekevdifglvkklrqerpylvqtkeqykfv

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1-234 1.1e-52 173.8 In-house 47-268 (515) alignment
Range on Protein: 1-234
Range on HMM: 47-268/515.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAKkv
||| ||||  ..||.||   .     | |.|| || .. .. . |||. ||.. ... |||.|.  .  .|.| | . |. ..||..||| .  .  |  
nryknilPydsvrvklevind..nPhsdyfnasyipsfdnd.kayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk..

gdriYGHISVAVCSGEQHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEeQRQGPPIVHCSAGIGRTGTFIAIDQAVR
    .|.|.| . | |   | |  .... ||.. . .  . |..|||.|||    .  .. ....|.|  . | . | |.|||||.|||| .|.||. | 
....fGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkh..tssllklikevkadhg.qythpliihcsaGvGrtGvvisidsvva

CLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
  ..|  || ...| |.|..|  .||  .|| ||
hakttrmvdvfnfvtnirqkrpylvqtqeqyafi

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1-234 1.9e-52 173.6 In-house 65-283 (319) alignment
Range on Protein: 1-234
Range on HMM: 65-283/319.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSqPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTpmmeqgRVKCARYWPtvryNEakkv
||..|||.  ...|.||         | |||| ...|| . .  |||| ||||||.. ||||.|  .. .||. |      . ||..|||    ..    
nriinilafdknvvklerliG..eefsdyinasfvtGyqr.kdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywp....lk....

GDRIYGHISVAVCSGEQHPGYILTHIRLRK-GKEE--QLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCE-EQRQGPPIVHCSAGIGRTGTFIAID
..  ...  | | | |.   |.. .|.| . |||.  . .. . |. |||.|||    . ... ....|| . . |. . . .||||||.||||..|..|
ivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdy..psdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivld

QAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
  .  ..|   ||  ..| ..|. |  .||.  || ||
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfi

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1-234 6.5e-52 171.8 In-house 29-247 (284) alignment
Range on Protein: 1-234
Range on HMM: 29-247/284.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSqPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTpmmeqgRVKCARYWPtvryNEakkv
||...||.  ...|.||         | |||| .|.|| . .  |||. ||||||.. ||||.|  .. .||. |      . ||..|||    ..    
nrighilafdknvvklerliG..eefsdyinasfitGyqr.kdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp....lk....

GDRIYGHISVAVCSGEQHPGYILTHIRLRK-GKE--EQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCE-EQRQGPPIVHCSAGIGRTGTFIAID
..  ...  | | | |.   |.. .|.| . |||   . .| . |. |||.|||    . ........|| . . |. . . .||||||.||||..|..|
ivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdy..psdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld

QAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
  .  ..|   ||  ..| ..|. |  .||.  || ||
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfi

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1-234 9.6e-52 170.6 In-house 50-275 (290) alignment
Range on Protein: 1-234
Range on HMM: 50-275/290.0
NRYTNILPNPRTRVRLEDEYEPWTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryneaKKV
||..||...   |. | .  .       |||| || ||. . ..|||. ||. ||.  ||...|  |...||| | ..|.|.|||  |||.      ...
nRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpd......sdt

GDriYGHISVAVCSGEQHPGYILTHIRLRKGKE---EQLLRHYWFQNWPDHG-VPSAEGAHQVIAMMQNVRafcEEQRQGPPIVHCSAGIGRTGTFIAID
 .  ||..|. . . |.. .|| ....... ..   .| . .| ..||...| |.  ..  .||. |.. .     . ... .||||...||...|.|..
ka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktq...rkrgntsivvHCSdtvgrsavfcaaa

QAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 ..   . .| .| .|.. ..|  . |.||  |||..|
ttinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgi

subfamily_PTPN1_pd Subfamily PTPN1 1-233 1.6e-51 169.8 In-house 36-262 (290) alignment
Range on Protein: 1-233
Range on HMM: 36-262/290.0
NRYTNILPNPRTRVRLEDEYEpwtsvsTYINANYIAgYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAKKV
||| .. |   .|..||..         ||||. .       |.|| . ||| ||.. ||.|||  || |.||   ..|....|||.|||.   ... ..
nryrdvspydhsrikleradn......dyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekelll

GDRiygHISVAVCSGEQHPGYILTHIRLRK--GKEEQLLRHYWFQNWPDHGVPSAEGAhqVIAMMQNVR-AFCEEQRQGPPIVHCSAGIGRTGTFIAIDQ
 |    ...| . | |..  |.. ...| .   .| . . |. .  ||| |||.. .|   . ....|| . .  . .||...||||||||.|||. .| 
edt...klkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaa..flkflfkvresGslssdvGpavihcsaGiGrsGtfclvdt

AVRCLEETGE---VDCLQIVANMRKHRGGMVQHPQQYEF
 .  .|....   ||  . . ..||.| |..| ..| .|
clvliekkddlssvdikkvllelrkyrlGliqtadqlrf

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1-233 3.2e-50 165.5 In-house 42-268 (287) alignment
Range on Protein: 1-233
Range on HMM: 42-268/287.0
NRYTNILPNPRTRVRLEDEYEpwtSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVryNEAKKV
|||...||   ||| |  | |     | ||||||.|.|  .  ..||| ||.  |.  |||.|.  .| .... |  .|..| || .|||    .   .|
nryadvlPiddtrvllsaege...lGsdyinanyvasytdd.eafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer..evPmrv

GdriyGHISVAVCSGEQHPGYILTHIRLRK--GKEEQLLRHYWFQNWPDHGVPSA-EG-AHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAID
|    |.  |..    ..| |    .|| .  ..| .... . . .|||.... .  | .  |. . |.. .  . .  ||..||...||||.|...|. 
G....GysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatl

QAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEF
  |. ||..|.||  ..|. .|..| ..|| . |. .
vlvsrledlGrvdvaavvirlreyraalvqavvqlrl

subfamily_PTPN23_pd Subfamily PTPN23 1-233 1.7e-48 159.9 In-house 47-271 (288) alignment
Range on Protein: 1-233
Range on HMM: 47-271/288.0
NRYTNILPNPRTRVRLEdeyepwTSVSTYINANYIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvRYNEAKKV
||...|||  ..|| |.       |   |||| .. . |..  ..||. .||..|.  ||.||.  ||. ||| .   |.|. |..||||. . .|..| 
nrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPe.dkgetvkf

GDriyghISVAVCSGEQHPGYILTHIRL--RKGKEEQLLRHYWFQNWPDHGVPSAEgaHQVIAMMQNVRA---FCEEQRQGPPIVHCSAGIGRTGTFIAI
||     .||.. | .. . ..  ...|  .. .. . ..|  ...||..|||..   .........|..     ... . | .||||||.||||.|  .
gd.....lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasP..etllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalv

DQAVRCLEE-TGEVDCLQIVANMRKHRGGMVQHPQQYEF
  ||| ||.  | .| .|.|  .|. |  |||. .|..|
yaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkf

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1-234 5.8e-48 158.3 In-house 51-270 (287) alignment
Range on Protein: 1-234
Range on HMM: 51-270/287.0
NRYTNILPNPRTRVRLEdeyepwTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryneAKKv
||.|.||.    || |.           |||| .| ||... ...|.| .|. ||.  ||....  . .|||| .  .|. . .| .|||.      |  
nRltqilvpdnyrvllk......gehpdyinavfidgykek.kafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpe.....eks.

gdRIYGHISVAVCSGEQHPGYILTHIRLRK---GKEEQLLRHYWFQNWPDHG-VPSAEGAHQVIAMMqnVRAfCEEQRQGPPIVHCSAGIGRTGTFIAID
   ..|. .... . |.. |||  ......    ...| .. | . ||...| |.. .    ||  |  ...    . ... .||||...||...|.|..
..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieem..ykt.qrkrgntsivvhCsdtvGrsamfcaaa

QAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 ...  .. | .| .|.. ..|  . |.||  .||.||
ttinkckteGviDvfqvlksqriqkpgsvqtveqykfi

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1-234 7.8e-48 157.8 In-house 37-258 (283) alignment
Range on Protein: 1-234
Range on HMM: 37-258/283.0
NRYTNILPNPRTRVRLEDEYEpwtsvsTYINANYIA--GYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPtvryneak
||. .|.|  . ||.|. | .      .|||| .|       | ..||.| .|||.|.  ||.||.  |  |||| |...|. |.||..|||        
nrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP........

KVGDRIYGHISVAVCSGEQHPGYILTHIRLRKG---KEEQLLRHYWFQNWpdhgvpSAEGAHQVIAMM---QNVRAFCEEQRQGPPIVHCSAGIGRTGTF
| |   ||   |..     .  .|   . ||.    |.. || || ...|         |   .|  .     |..   |...|| .||||.|||||..|
krGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW......leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavf

IAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
||.  .|  .     ||  ..| .||..| ..||  .|| ..
iaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklv

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1-234 5.8e-47 155.1 In-house 53-271 (315) alignment
Range on Protein: 1-234
Range on HMM: 53-271/315.0
NRYTNILPNPRTRVRL-EDEYEPwtsVSTYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVryneakk
||| ||..  ..||.|   | .|    | |.|||.| ||. ..| |||| ||. .... |||.|.  .   ||| | ..|. . |. .|||         
nryiniiaydksrvqlpllendp...hsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.......

vgDRIYGHISVAVCSGEQHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEEQRqGPPIVHCSAGIGRTGTFIAIDQAV
  . |||.|.|.  | |..  |    .    |.. . .  . .  ||| |||    .  .. ....|. . ...  |. .||||||.|||||||..|  .
..kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpky..tiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavl

RCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
  .|    .|  ... ..|. | .|||  .||.||
dqaeaenaidvynfitgvrqnrikmvqvaeqyqfi

0041856 (Phosphotyrosine protein) phosphatases II 1-234 7.5e-45 148.1 In-house 5-163 (182) alignment
Range on Protein: 1-234
Range on HMM: 5-163/182.0
NRYTNILPNPRTRvrledeyepwtsVSTYINANYIAGYSSQPReYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTpmmeqgrvkCARYWPtvryneakkv
|||..|||....|            ...|||||...|.  . | .||. |||..|...|.||..  .  .||. |         . .|||          
nrysdilpydhsr............dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

gdriyghisvavcsgeqhpgyilthirlrkGKEEQLLRHYWFQNWPDHGVPSaegAHQVIAMMQNVRAfceeqRQGPPIVHCSAGIGRTGTFIAIDQAVR
                               ..|.|  .|.. .|||||||.    ........ |..     ..|| .||||||.|||||..|..   .
..............................ellerlgiqylylpwpDhgvpd...ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkk

CleetgEVDCLQIVANMRKHRGGMVQHPQQYEFI
.     .|.  ..|. .|..| |||..|.|| |.
l.....gvsleeavklvrsrRpgmvitpnqyffl

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1-234 7.9e-45 147.9 In-house 7-231 (237) alignment
Range on Protein: 1-234
Range on HMM: 7-231/237.0
NRYTNILPNPRTRVRLEDEYEPwtsvSTYINANYIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAkkv
||| ||     .|| |.         | ||||.|. |.   |..|||| |||... . ||.|||  |   ||| | ..|. ..|| .|||     .|   
nrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa...

gdriYGHISVAVCSGEQHPGYILTHIRLRK---GKEEQLLRHYWFQNWPDHGVPSAEGAhqVIAMMQNVRAFCEE-QRQGPPIVHCSAGIGRTGTFIAID
    || ..|...  |.   | .  . | |    || .|.  | |  |||.|||    |  .. . .|.    .  .. || |.|||||.|||| |. ||
....ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaa..llrfrkniinrsphvsesgpwiihcsagvgrtgiflvid

QAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
  .|  .|   ||  . | .. . |  ..|  .|| ||
amlrqakekkvvdiynyvysieedrpyiiqtkdqyvfi

subfamily_PTPN14_pd Subfamily PTPN14 1-234 2.5e-44 146.5 In-house 53-288 (300) alignment
Range on Protein: 1-234
Range on HMM: 53-288/300.0
NRYTNILPNPRTRVRLEDEYEPwtsVSTYINANYIA-GYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYnEAKK
||. ..||   .||.|    |     . ||||  |    ... |.||.| |||..|.. ||.|||  .   ||| |   |.|. |. .|.|     ..|.
nrfkdvlPyednrvelsptken...stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkles.kkkt

VgdrIYGHISVAVCSGEQHPGYILTHIRLRK--GKEEQLLRHYWFQNWPDHGVPSA-EGAHQVIAMMQNVRAFCEEQR-----QGPPIVHCSAGIGRTGT
|    .|.  |     |. . .| | ..|.    |||. . |  ...|||||||.  .|  . . ..| ||   ....     . | .||||||.|||| 
v...efgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGv

FIAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 |  |  . .||   |.|  ...| .|. |  .||   ||.|.
lilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfv

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1-231 2e-41 136.5 In-house 60-272 (290) alignment
Range on Protein: 1-231
Range on HMM: 60-272/290.0
NRYTNILPNPRTRVRLEDEYEpwtsvSTYINANYIAGYSSqprEYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRyNEAKkv
||| ..  | .||| |.| |.       |. |||. |  .    .| . |.| .|.  .||||   |  ||||   ..|.|. ||..|.|     |.   
nrykdvvcndktrvilkdGyd.....GdyvhanyvkGlka...mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypeke.Gevl..

gdrIYGHISVaVCSGEQHPG-----YILTHIRLRKGKEeQLLRHYWFQNWPDHGVPSAEGAhqVIAMMQNVRafceeQRQGPPIVHCSAGIGRTGTFIAI
    .|.|.| .|| |...       .|.     .|||   |.|.  . |||. |. .. |  .. ... .|     .  || .|||||||||||||.||
...tfGeitv.lcseeddkdaniikktlsvrdkdsGke.hklkhlkikswpdksvalstla..llrtlrilr.....kasGpvvvhcsaGiGrtGtfvai

DQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQY
. ....| .  |.| |..|  .|. | . ||   ||
evglqilldGkeldlldlvralrnsrlnsvqvdiqy

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1-233 3.4e-41 136.4 In-house 52-279 (325) alignment
Range on Protein: 1-233
Range on HMM: 52-279/325.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTpMMEQGRVKCARYWPtvryneaKKV
||. |...  ..|| ||   .   . | ||||.|.  .  .   ..||  || .||. .||.|   ... .|..  ....|  .|| |||       |..
nrfknvvaldksrvvletkkd..dpssdyinasylrddkkk.dvflaaqaPltatindlWrlvldWrcsvvvvln.eldlgkdrcavywp.......kem

GD-RIYGHISVAVCSGEQHPGYILTHIRLRKGK--EEQLLRHYWFQNWPDHGVPSAEGahQVIAMMQNVRAFCEEQR-----QGPPIVHCSAGIGRTGTF
|. . .| . | . . |.   |.   . ... |  | . .. . .| |.| ||.       .|...| | |  |  .      .| .||||||.||||.|
gksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpa..tlisilqlvkavservtantkastpilvhcsaGvGrtGvf

IAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEF
|..  |.  . |  .|| .. | ..||.|  ||.   || .
islysalakvieesrvdifgfvkklrkdrpsmvetvdqyil

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1-234 7.4e-41 135.0 In-house 52-271 (439) alignment
Range on Protein: 1-234
Range on HMM: 52-271/439.0
NRYTNILPNPRTRVRLEDeyEPWTSVSTYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRvkcarYWPTvrynEakkv
||| .. .   ||| |..   |    | ||||||| ||  ... |||. || ..| . |||.|.  |.  ||| | ..|  .     |||.    .    
nrykdvgafdhtrvtlqe..ipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywps....d....

GDRIYGHISVAVCSGEQHPGYILTHIRL----RKGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAID
.. .|| |.| |    . | |..  ...     ... |. . .. .  |||. ||.   |  |. ... . .  ...  || .||||||.||||| ||.|
aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaq..ashvldflrainsandkeeygpvvvhcsagvGrtGtiiald

QAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 |.  |    .||   ||  .||.|  |||.  || ||
ialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfi

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1-234 1.8e-39 130.4 In-house 37-287 (297) alignment
Range on Protein: 1-234
Range on HMM: 37-287/297.0
NRYTNILPNPRTRVRLEDEyepwTSVSTYINANYIAGY-SSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRyNEAKK
|||..||    |||.|        . . ||||.|..     ..  || | |||..|.. ||..|.     .||| . . |.|| ||| ||| |  .| .|
nryrdilatddtrvkllrv....iterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv.qerlk

VGDRIYGHISVavCSGEqHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVPS-AEGAHQV--------------IAMMQ--------NVRAF-CEEQRQ
 || .  ..|    | | .   ||| ..|   .|.. .||  | .||||||||  |   .               .|...        .. ..  |  |.
agdvvveflss..tsde.fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprn

GPPIVHCSAGIGRTGTFIAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 . .||||||.||.|  .  |  .  |      |   |.  .|. |  .||  .|.|..
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfell

0049772 (Phosphotyrosine protein) phosphatases II 1-234 5.8e-39 130.0 In-house 50-272 (314) alignment
Range on Protein: 1-234
Range on HMM: 50-272/314.0
NRYTNILPNPrTRVRLedEYEPWTSvSTYINANYIAGYssqpREYIAAMGPLDNTIEAF----------WRMV--WMVKSPAIVM---------------
|||..||| . .||.|   ..|  . | ||||.|. |.    . .||. |||..|.. |          ||||  .  ..  |||               
nryldilpad.nrvil..pglpvsg.sdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLda

------TTPMMEQGRVKCARYWPTVRyneakkvgDRIYGHISVavcsgeqhpgyilthirlrkgkeEQL-LRHYWFqNWPDHGVPSAEGAHQVIAMMQNV
       ......|   .|..... .        ...| .  .                       |.| ...... ..||...|. |   .........
AlgKtpllildgngneptaadlellk........eelydpelf.......................erlgikylri.pvpDgsaplledfdeflefieea

rafceeQRQGPPIVHCSAGIGRTGTFIAIDQAVRCLeetgEVDCLQIVANMRKHRG-----GMVQHPQQYEFI
      ...|| .|||.||.||||||....  ...|     |.  .... .|. |      |... ..|||||
......dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefi

subfamily_ptpA1_pd Subfamily ptpA1 1-195 2.2e-38 127.1 In-house 51-249 (418) alignment
Range on Protein: 1-195
Range on HMM: 51-249/418.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGysSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAKK-
||||||||  .|||.|.   .     | ||||||| |  . |...|.. ||| |||  ||||||  .   ||| .   |. |.|| ||||     |    
nrytnilpvnhtrvqlkkiqd..kegsdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsi

--VGDRIYGHISVAVCSGEQHPG--YILTHIRLRKGKEEQLLRHYWFQNWPDHGVPSAE-GAHQVIAMMQNVR--AFCEEQRQGPPIVHCSAGIGRTGTF
   |. ..|  || .    | |    |   |||    | . . .| .. |||| .|      .|..  . | .       .|. | |||||||.||||||
ygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtf

IAI
 . 
cta

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1-234 2.8e-38 126.3 In-house 44-285 (301) alignment
Range on Protein: 1-234
Range on HMM: 44-285/301.0
NRYTNILPNPRTRVRLEDEYEPWTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAKK-
||. || . .  |. |. . .  ..  .||||.|| |||.. ...||| ||...|.  |||..|  |  .||| | . |. . || .|||. . .. .  
nrfknitvyddnriilkpkpnldlcqreyinasyidgysek.kkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefg

-----------VGDRIYGHISVAVCSGEQHpGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVpsAEGAHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGR
           . | .  ...| .  | .. |||  ... .. |. . .  .   .||..||      . |.  ...|         || .||||....|
pftvtlvneqvyPdfvirqlnvkiqdgsnn.gyierkfkvksdksswdvlqlqvtdWpqdGv..vreprtvLqviddvihrqqkigggpvvVHCSdtVsr

TGTFIAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.|...... ..      | ||  |..  .|. . |.|.  .|| .|
sGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsi

subfamily_CG7180_pd Subfamily CG7180 1-234 3.7e-38 125.9 In-house 46-282 (296) alignment
Range on Protein: 1-234
Range on HMM: 46-282/296.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRvKCARYWPTVRyneakkv
||. ...|   .|| ||       . | |||| |. ..  ...|||   .| ..|...|||.|.  .. |.|. |  ... . ..  |||          
nrdvkvvPyDynRvvLekldG..eeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.......

gDRIYGHISVAVCSGEQHPGYILTHIRLRKG------------KEEQLLRHYWFQNWPD-HGVPSA-EGAHQVIAMMQNVRAFC-EEQRQGPPIVHCSAG
    ||.| | . . .| .      ..| |              |. ..... .. |.  . ||.  ..  ... ... .|    |.. .|| .|..| |
.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdG

IGRTGTFIAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 .|.| ..||| ..  .|...|||  . |  .|..| ..|.  ..| .|
asRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyi

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1-234 1.1e-37 124.5 In-house 12-233 (239) alignment
Range on Protein: 1-234
Range on HMM: 12-233/239.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRyneAKkv
|||.||.   ..|| ||   .     | ||||.|.  |   |. |||. | .  .   ||||.|  .   ||| | ..|  . || .|||      .|  
nryanivtydhsrvvleklsn..dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst...sk..

gdriYGHISVAVCSGEQHPGYILTHIRL-RKG-KEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEeQRQGPPIVHCSAGIGRTGTFIAIDQA
    |  . |..   |    ||.  . . . |  ||. . .| |  |||.|||    |  |. . ...          | ..|||||.||||.|. ||  
....ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy..atavlglrrkitkdsl.pgarpwvihcsagvgrtgaflvidam

VRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.|  ..   || .. |  .|. |  |||  .|| ||
lrqakkqktvdifnyvkairedrphmvqtseqyvfi

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1-234 1.1e-37 124.5 In-house 11-232 (239) alignment
Range on Protein: 1-234
Range on HMM: 11-232/239.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRyneAKkv
|||.||.   ..|| ||   .     | ||||.|.  |   |. |||. | .  .   ||||.|  .   ||| | ..|  . || .|||      .|  
nryanivtydhsrvvleklsn..dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst...sk..

gdriYGHISVAVCSGEQHPGYILTHIRL-RKG-KEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEeQRQGPPIVHCSAGIGRTGTFIAIDQA
    |  . |..   |    ||.  . . . |  ||. . .| |  |||.|||    |  |. . ...          | ..|||||.||||.|. ||  
....ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy..atavlglrrkitkdsl.pgarpwvihcsagvgrtgaflvidam

VRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.|  ..   || .. |  .|. |  |||  .|| ||
lrqakkqktvdifnyvkairedrphmvqtseqyvfi

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1-234 2.3e-37 123.3 In-house 49-228 (392) alignment
Range on Protein: 1-234
Range on HMM: 49-228/392.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGrvkcarywptvryneakkv
||| ||||  ..||.||   .  .. | |.|| || .. .. . |||. ||   ... |||||.  .  .|.| | . |                     
nryknilpydsarvklevidd..ipdsdylnasyipsfdne.kayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...................

gdriyghisvavcsgeqhpgyilthirlrKGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAFCEeQRQGPPIVHCSAGIGRTGTFIAIDQAVR
                             ||.. .    . | .|||..||    .  .. ....|.|    |   | |.|||||.||||  |.||  | 
.............................kgddartvaqfhftewPdkdvpkh..tssllkfikevkadfG.qythpliihcsagvgrtgvvisidsvva

CLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
  ..|  || ...|.|.|..|  |||  .|| ||
hakktrmvdvfnfvtnirrkrpymvqtkeqyafi

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1-234 1.2e-36 121.2 In-house 45-269 (307) alignment
Range on Protein: 1-234
Range on HMM: 45-269/307.0
NRYTNILPNPRTRVRLEDEyepwTSVSTYINANYIaGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAkkV
|||...    ..|. .. .       | || |||. | . .|. .|.| |||.||.  || |.   |  ...|   ..| ...|| .||| .. ..   |
nryqdvkcqdkgrivvkfd....glasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqkl..v

GDRIYGHISVAVC-SGEQHPG---YILTHIRLRKGKEEQLLRHYWFQNWPDHGVPSAEgaHQVIAMMQNVRafceeQRQGPPIVHCSAGIGRTGTFIAID
       ||||   ...  |      .| ...  ... . ..|. ..||||.|||  .     | ... ||       . | .||||||.||.|| .|| 
fgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqin..ltainlleavr.....ydtnpvvvhcsaGvGrsGtivais

QAV-RCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
    . ..     |  ..| ..|..|   .|   || ..
lvqdkmiaGinckdmkklveelrsqrhyaiqteaqylyl

subfamily_PTPRN_pd Subfamily PTPRN 1-234 1.9e-34 113.7 In-house 60-284 (297) alignment
Range on Protein: 1-234
Range on HMM: 60-284/297.0
NRYTNILPNPRTRVRLEDEYEpwTSVSTYINANYIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPtvryNEakkv
||....||   .||.|..| .  .. | ||||  |     .   |||. ||| .|. .||.|||   .  ||. |.. |.|  .|.||||    .|    
nrskavlpydhsrvklkeeas..aeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywp....de....

GDRIYGHISVAVCSGEQH-PGYILTHIRLR--KGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAfCEEQRQGPPIVHCSAGIGRTGTFIAIDQ
|  .|.   | . |       |..  . |.  . .| . .  . |  ||..|||..  |. .. . . |   .   |  | .||||.| ||||..|.|| 
GsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPas..aksllefrrkvnk.syrGrscpivvhcsdGaGrtGvyilidl

AV-RCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 . | |    |.|    .  .|  | |.|.  .|.||.
vlnrllkGvkeidiaatlehlrdqrpglvktkdqfefa

subfamily_CG42327_pd Subfamily CG42327 1-168 2.1e-34 113.6 In-house 32-192 (319) alignment
Range on Protein: 1-168
Range on HMM: 32-192/319.0
NRYTNILPNPRTRVRLEDEyePWTSVSTYINANYIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvrynEAKKV
.|. |..| | ||| |.    .    . |..|.|. || . |  ||||  .|...  .|||.||  .|  ||  | . |.|  .||.|.||    ..   
srvinvvPlPetrvvlqri..gdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPt....ketld

GDRIYGHISVAVCSGEQHPGYILTHIRLRK--GKEEQLLRHYWFqNWPDHGVPSAEGAhqVIAMMQNVRA
. . ||.| |..  .| .  |... . |..  ..| . | |||. .|.. .||. | |  .|||. .||.
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaa..liamllevrs

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1-234 3.3e-33 109.6 In-house 59-281 (305) alignment
Range on Protein: 1-234
Range on HMM: 59-281/305.0
NRYTNILPNPRTRVRLEDeyePwtSVSTYINANYIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAKKV
|||...  . .. |.|..   |  | | || |||.       . .|.| ||||.||. || ||   |   |||    .| |..|||.|||. . .  .  
nryqdvpcqdqsavkldk...p..spsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelk

GDRIYGHISVAvCSGEQHPGYILTHIRLRK-GKEEQLLRHYWFQNWPDHGVPSAEGAhqVIAMMQNVRAfceeqRQGPPIVHCSAGIGRTGTFIAIDQAV
.  .   .| .    |. .   .| ..|   |...  .||  . .||| ||| .  .   . ..  .|       . | .|||||||||||| .||.  .
sgivvenvsgs.kpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppcklt..slellsairg.....skvpivvhcsagigrtgtivaieyil

RCLEETGEVDCL-QIVANMRKHRGGMVQHPQQYEFI
  . |  ..  . ..|  .| .|   .|   || ||
ekiaenkpcppmpelvkalrdqrafsiqndvqylfi

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1-234 1.1e-32 107.8 In-house 41-261 (281) alignment
Range on Protein: 1-234
Range on HMM: 41-261/281.0
NRYTNILPNPRTRVRLEDEYePWTSVSTYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvrynEAKKV
|||.||     .||.|. .  |    . || ||||       | || . ||  .|   ||||.|  .. ||||   ..|  | ||| |.|     .|. .
nrylnipcldisrvqlkvkm.pnknstdyihanyirspf.lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfpr....nahcc

gdRIYGHISVAVCSGEQHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVRAfceeqRQGPPIVHCSAGIGRTGTFIAIDQAVR
    . ..||.          . |.. |    | .|. |. ...|||  || .  .  .. .....||     |  ||..|||||.||.||..|.. |..
..lqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpes..sevmlkilrkira.....rstppvihcsagvgrsgtlmaveialq

CLEETG-EVDCLQIVANMRK-HRGGMVQHPQQYEFI
 .       |  |||. .|   |   ||  ||| .|
sihshftlpdikqivshlrvtgraasvqtlqqymli

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1-234 5.4e-31 102.5 In-house 52-279 (305) alignment
Range on Protein: 1-234
Range on HMM: 52-279/305.0
NRYTNILPNPRTRVRLEdeyEPWTsvSTYINANYIAGySSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNE--AK
||| ..    . ||.||    ||     || |||..   ..|. .| .  ||..|   || | .  |  || |   ..|.|  ||. |...   ..   .
nrykdvgcldnnrvkle...gpwp..heyihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefe

KVGDRIYGHISVAV-CSGEQHPGYIL--THIRL-RKGKEEQLLRHYWFQNWPDHGVPSAEGAhqVIAMMQNVRAfceeqRQGPPIVHCSAGIGRTGTFIA
. |..|  ..  .|  . ...    .  | . .   |.. .   || . .||| |||.|. |  .. .... |.      .|| .|||||||||||. . 
ekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadla..ilellekarp.....skgpivvhcsagigrtgsvvm

IDQAVRCLEETGEV-DCLQIVANMRKHRGGMVQHPQQYEFI
..  .  | .   . |. .|.  .|. |   .|  .|| |.
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfv

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1-233 4.4e-28 93.1 In-house 47-262 (288) alignment
Range on Protein: 1-233
Range on HMM: 47-262/288.0
NRYTNILPNPRTRVRLEdeyepwTSVSTYINANYIAgYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRyNEAKKV
.||.|.     |||.|.           ||.|| ..  .  .|  | |  ||. ||| .|.|.       ||| . ..|.|. | | |.|..   |. ..
dryenlprcditrvkls......ddpdfyiaanvvs.sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl.Gekari

GDRiYGHISVAVcSGEQHpGYILTHIRL-RKGKEEQLLRHYWFQNWPDHGVPSAegAHQVIAMMQNVrafceEQRQGPPIVHCSAGIGRTGTFIAIDQAV
|      . .   .. ..    .. .|  ..|.|......  ...|.|.|||        . ... .     .. | | .||.|||.|||||.| |  |.
grl.ctvvkkkr.adidk.lvkvsllriskegeekvivkilhlleWdddgvPen..ylsplrllevl.....kslqkPivvhssaGvGrtgtlililial

RCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEF
. |  .  .   ...|..|..|   .|  .|| .
eslrlddflgirsllaklreerfkaiqtemqyly

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1-232 1.5e-26 87.8 In-house 47-266 (312) alignment
Range on Protein: 1-232
Range on HMM: 47-266/312.0
NRYTNILPNPRTRVRLEDEYepwtsvSTYINANYIAgYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYnEAKKV
||| ||    | |  |  .         || ||..    ..|  .... |||.||.  ||...  . | .|.. . ..|.|  |||.|   .     .  
nrypniqcwdrgrftlagde......nfyihanfvk.ictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivg.fvdle

GDRIYGHI----SVAVCSGEQHPGYILTHIRLRKGKeEQLLRHYWFQNWPDHGVP-SAEGAHQVIAMMQnvrafceeQRQGPPIVHCSAGIGRTGTFIAI
  |.|        .   | ..    .|  .    |. |  | || .  |||||.| | . |..... ..        . . | | |||||.|||||.. |
dhrvyteycteieiggkskdkithrvlkvvvkatgq.esklnhyqwaswpdhgmpdscdtalrllsavk........kdkkpviahcsagvgrtgtlali

DQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYE
.  . .|      .  ..   .|| |   |.   || 
esmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyv

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1-233 9.3e-25 82.1 In-house 37-250 (267) alignment
Range on Protein: 1-233
Range on HMM: 37-250/267.0
NRYTNILPNPRTRVRLEDEYEPwtsvstYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQgrvKCARYWPTvRYNEAKKV
||. . ||   ||| | .. |       |||| |. ||  . . .|.  .||.|||  |. ..   | | ||. |.  ..   .  ..||  .  .||| 
nrlddnlpyddtrvilrtkeee......yinasyvegyktk.nafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPP.kmgqakky

GDRIYGHisvAVCSGEQHPGYILTHIRLrKGKEEQLLRHYWFQNWPDHGVpsaegAHQVIAMMQNVRAFCEEQRQG-PPIVHCSAGIGRTGTFIAIDQAV
 |    |   ..   |.    |   ... | .  . .  |....|           .  .  .  . |  . .  . | .|.||.|.||.|||. ||  .
qdltveh...slekeendyqiitlelkf.knesahnvtlyyykkwnintn.....nkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsql

RCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEF
. . . | .|  . . ..|. | |.|.  ..| .
eraktegvsdifdflrkirsqriglvdtkeryiy

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1-97 2.5e-20 67.5 In-house 51-158 (350) alignment
Range on Protein: 1-97
Range on HMM: 51-158/350.0
NRYTNILPNPRTRVRLE------DEYEPWTSVSTYINANYIAGY----SSQPRE-YIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYW
|||.||||  ..||.|.      |  .  .| . ||||||.       . .|   |||. .|| .|.. |....   | . |.. |. .|... || |||
nrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYW

PTVRYNEA
.   |.. 
qegsyddi

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1-96 3.4e-15 50.4 In-house 56-147 (310) alignment
Range on Protein: 1-96
Range on HMM: 56-147/310.0
NRYTNILPNPRTRVRLEDEYepwTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNE
|||....    .||.|. .    .    || |||.     .   .| . |||. ||  ||||..  .. .|..   ..|.|| ||  |||..   |
nrysdvvcldtsrvklkidk...sryedyihanyvktnylr.stficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvte

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1-97 9e-11 35.7 In-house 52-161 (349) alignment
Range on Protein: 1-97
Range on HMM: 52-161/349.0
NRYTNILPNPRTRVRLEDEYEPWTS------------VSTYINANYIAGYS-SQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCAR
||| .|||   .||.|.   ..  .            .  ||||||.     |  . ||| . ||  |.. |.... . . . ..  .   |..  || .
nrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdi

YWPTVRYNEA
||    |.. 
ywqelsysni

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2-233 7e-27 89.1 In-house 40-261 (285) alignment
Range on Protein: 2-233
Range on HMM: 40-261/285.0
RYTNILPNPRTRVRLEDEYepwtsvSTYINANYIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvRYNEAKKVG
||...     ||| |..          || |...     .   ||.. ||| .|.  ||.|..  |   ..|   ..| |  ||| |.|  .  |  |.|
ryadvrcieetrvvlknhd......rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype.klgevvkfg

DriYgHISVAVCSGEQHPGYILTHIRLR---KGKEEQ-LLRHYWFQNWPDHGVPsaEGAHQVIAMMQNVRAFceEQRQGPPIVHCSAGIGRTGTFIAIDQ
   |  |... |  |   | ||  . .        |   . |     |||.  |  | |. .| . . |.    . .. |  ||||||.||| ||. || 
k..y.eitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlap..edarpmielykwvkkv..npkekpicvhcsagvgrtatfvgidy

AVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEF
|   . |  ... |.|| .||  |   ||   |. |
atirimenpniemldivremramrfqavqshmqflf

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2-231 7.6e-27 88.8 In-house 55-270 (301) alignment
Range on Protein: 2-231
Range on HMM: 55-270/301.0
RYTNILPNPRTRVRLEDEYEpwtsvSTYINANYIAGYsSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYnEAKKVG
|| ..  .| | |.. .. .        | ||.|     .|. .||. |||.|| | || |. . .   ||| .  .|.   ||. | |.    |  ..|
ryptvPckPstavevivdGk.....rvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis.ekldig

DRIYGHISVAVCSGEQHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVPSAEgaHQVIAMMQNVRafceeQRQGPPIVHCSAGIGRTGTFIAIDQAVRC
       .  .   ..     |      .  . . . || ...|.|.||| .    ..  .|. |.     . . | .|||||||||. .||. .   | 
rfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPksh..aelfdlmelvk.....ksekPivvhcsaGiGrsvafigteylare

LEETGEVDCLQIVANMRKHRGGMVQHPQQY
.|   ...  . ....|.||   ||. .| 
veadptieltealkhlrehrwngvqtnsql

subfamily_eak_pd Subfamily eak 5-205 3.3e-17 56.9 In-house 59-266 (332) alignment
Range on Protein: 5-205
Range on HMM: 59-266/332.0
NILPNPRTRVRLEDEYepwTSVSTYINANyIAGYSSQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAKkvgdri
.|.|. |  |||            ||||  .| .|   |.|| .  . .. . |||.||   ||||||.    .|..  |  .|.|    .| |      
kivpydrylvrltssq...lnrlGyinas.laefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelk......

YGHISVAVCSGEQHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGVPSAE------------GAHQVIAMMQNV-RAFCEEQRQGP----PIVHCSAGIG
.|.. |   .  ..  .    . |.|| |   . || .  | .  .|  |            |. ..| | ... ...       |    ||. .. |  
fGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsa

RTGTFIAIDQAVRCLEET
|.|.|. ||  .| ... 
raGvfvvidllirlidnk

subfamily_egg_pd Subfamily egg 12-234 2.9e-23 77.0 In-house 55-262 (307) alignment
Range on Protein: 12-234
Range on HMM: 55-262/307.0
TRVRLedEYEPWTSVSTYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQgrVKCARYWPTVRYNEAKKVGDRIygHISVA
.||.|  |..    .  .| ||.. |      |.| |  || || . |||||.  . . ||| |   |    .|  |||    . .. |   .  .|   
srvkl..elrrGqylddfihanrvkGkp.llnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGsl..rienl

VCSGEQHPGYILTHIRLRKGKEEQLLRHYWFQNWPDHGvpsaeGAHQVIAMMQNVRafceeQRQGPPIVHCSAGIGRTGTFIAIDQAVRCLEE--TGEVD
    .  | . .|...|  |..|..   .|  ..   .       .  . ... .|     .   | .|..  |. ...|..||. |.  |    .    
kvdskadplfrvtklklvGgddeerflehwqgdvnnss.....dvysplrvlrklr.....nlskpvvvqdilGvskaatlvaieiallsllrGpitksl

CLQIVANMRKHRGGMVQHPQQYEFI
 |. |  .|..|   |. . .| |.
vlravvflrlrrrlsvesvllylfv

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 12-73 3.8e-08 27.2 In-house 52-115 (347) alignment
Range on Protein: 12-73
Range on HMM: 52-115/347.0
TRVRLED---EYEPWTSVSTYINANYIAGYSSQpREYIAAMGPLDNTIEAFWRMVWMVKSPAIVM
||| |     .  .   | ||||| .|    .. .||| .  || .|.  ||.|| ..|   .| 
trvvlspeksknsraddvetyinashikfdnas.keyiltqyplpdtvrdfwkmvsvtkvtqvvt

0044763 (Phosphotyrosine protein) phosphatases II 13-234 2.8e-29 97.4 In-house 4-163 (178) alignment
Range on Protein: 13-234
Range on HMM: 4-163/178.0
RVRLEDEYEPWTSVSTYINANYIAGYssqprEYIAAMGPldntiEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYneakkvgdriyghisvav
| |   .  ...  | ||||..| ..      |... .|     ........  .  .||. |. .| |..|| .|||.                     
rtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..................

csgeqhpgyilthirlrkgkeeqllRHYWFQNWPDHGVPS-AEGAHQVIAMMQNVRafceEQRQGPPIVHCSAGIGRTGTFIAIDQAVRCleetgEVDCL
                          .| . ..||||||.  |  ...........    ....|| .||||||.||.||..|..   ..      ..  
.........................iqylhipipDhgvpdllehflefvefieeal....dekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsle

QIVANMRKHRGgMVQHPQQYEFI
.... .|..|  .|..| |....
eaielvrerRp.ivpnpgqlrqL

0051429 (Phosphotyrosine protein) phosphatases II 25-234 2e-43 144.3 In-house 2-217 (272) alignment
Range on Protein: 25-234
Range on HMM: 2-217/272.0
SVSTYINANYIAGYsSQ---PREYIAAMGPLDNTIEAFWRMvWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNE----AKKVGDRIYGHISVAVCSGEQ
..|.||||... ||  .   |. .... |||..|.. |||. .  .  .||. .. .|.||.|| |||| .||         . .  ||...| . | |.
plsgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

HPGYILTHIRLR---KGKEEQLLRHYWFQNWPDHGVPSAEgAHQVIAMMQNvrafceeqrQGPPIVHCSAGIGRTGTFIAIDQAVRCLEETGEVD-----
.. |||....|.   . .|   ..|.....|||||||. .  .........         .|| .||||||..||||..|..  .. ....  ||     
lldyilrellltlllsagearevmhlhytdwpdhgvpqea.llellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

---CLQIVANMRKHRGGMVQHPQQYEFI
    ...|. .|..| |.||...||.|.
nlyleeaveelraqrpgavqteeqylfl

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 25-232 1.2e-12 42.0 In-house 67-269 (303) alignment
Range on Protein: 25-232
Range on HMM: 67-269/303.0
SVSTYINANYIAgYSSQPReYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPtvRYNEAKKVGDRIyghISVA-VCSGEQHPGYIL
| |.|| |.|.    |. .  | .  ||  |   ||.|.   |   ...     |  ..     .|  | ..  |  .|    | |      |   |. |
sdssyihasyle.ldsskk.ailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfp..rnqdflkfeers...irvgefkrvelgdgwvl

THIRLRKGKEEQLLRHYWFQNWPDHGVPSAeGAHQVIAMMQNVRAFCEEQRQGPPIVHCS-AGIGRTGTFIAIDQAVRCLE-ETGEVDCLQIVANMRKHR
  . . .|.   .|  . ...||   .||  |. ...  . .....     .. | |. | .| ||.|||  .. |   |  |   .| .. . |.|. |
kvlsvsngdyksflhvhhykawphnsipsd.gspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngr

GGMVQHPQQYE
   ||   |. 
lhavqnlsqfs

0046846 (Phosphotyrosine protein) phosphatases II 26-234 1.1e-38 128.1 In-house 11-165 (176) alignment
Range on Protein: 26-234
Range on HMM: 11-165/176.0
VSTYINANYIAGYssqprEYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRYNEAkkvgdriyghisvavcsgeqhpgyilth
 ..|||||.|.|.      .||  ||| .|...|..|..  .  |.|. | ..| ||.||..||| .. ..                             
dldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

irlrkgkeeqllrHYWFQNWPDHGVPSAEGAHQVIAMMQNVRafcEEQrqGPPIVHCSAGIGRTGTFIAIDqavrcLEET-GEVDCLQIVANMRKHRG-G
             .|.. .|||||||. |  ...........   .|   || .||||||||||||..|..     | |.   .. ....| .|..|  |
.............qylhlpwpDhgvpdlelllellefireal...keg..gpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqRplg

MVQHPQQYEFI
.||.|.||.|.
avqtpeQyrfl

0051082 (Phosphotyrosine protein) phosphatases II 26-234 2.4e-29 97.3 In-house 2-145 (151) alignment
Range on Protein: 26-234
Range on HMM: 2-145/151.0
VSTYINANYIAGYssqpreYIAAMGPLDntieAFWRMVWMVKSPAIVMTTPMMEQGrvKCARYWPTVRyneakkvgdriyghisvavcsgeqhpgyilth
.|.|||..|. |.      ...  |||.    .|.....  .  .||. .. .| |  .|..|.|                                   
lsdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

irlrkgkeeQLLRHYWFQNWPDHGVPSAegAhqviAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQAVRCleetgeVDCLQIVANMRKHRGGMV
           ..|... .|||.|.|         . ....  .......|| .||||||.|||||..|..   .       |.  .... .|..|.|.|
.........ievlhipildwpdpglpls..f....davleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvv

QHPQQYEFI
|..||. |.
qpnqqflfq

0036282 (Phosphotyrosine protein) phosphatases II 27-234 4.8e-41 135.7 In-house 2-162 (174) alignment
Range on Protein: 27-234
Range on HMM: 2-162/174.0
STYINANYIAGYSSQPrEYIAAMGPLDntieaFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryneakkvgdriyghisvavcsgeqhpgyilthi
|.||||... ..   | ..||  |||.     ||.|..  .. ..|| .. .| |..|| .|||.                                   
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

rlRKGKEEQLLRHYWFQNWPDHGVPSAEGahqVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQAVRCLEeTGEVDCLQIVANMRKHRGGMVQ
  ..  .|.|  .|.. .|||||||. .    .. ... |. ...| ..|| .||||||.|||||..|..   |.|. .. || |..|. .|..|.||||
..lredlerlgiqylylpwpDhgvpdlsi...llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvq

HPQQYEFI
.|.||.|.
tpsQyrfl

0043147 (Phosphotyrosine protein) phosphatases II 27-234 3.1e-38 126.6 In-house 5-153 (172) alignment
Range on Protein: 27-234
Range on HMM: 5-153/172.0
STYINANYIAGYSsQPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMmeqgrvkcarywptvryneakkvgdriyghisvavcsgeqhpgyilthi
|.||||.|. .|   |...||  |||.||.. ||||..  .  .||. |.                                                  
sdyinasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

RLRKGKEEQLLRHYWFQNWPDHGVPSAEGAHQVIAMMQNVRafcEEQRQGPPIVHCSAGIGRTGTFIAIDQAVrcleetGEVDCLQIVANMRKHRGGMVQ
 . . ..|.|  .|.. .|||||||..|   ...  ....     ....|| .||||||.|||||..|..           .. ...|| .|..|.|.||
lydpellerlgiqylylpwpDhgvpllellleflefidell...alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavq

HPQQYEFI
.|.|| |.
npsqyrfl

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 27-234 4.6e-18 60.4 In-house 46-251 (290) alignment
Range on Protein: 27-234
Range on HMM: 46-251/290.0
STYINANYIAgYsSQPREYIAAMGPL-------DNTIEAFWRMVWMVKSPAIVMTTPMMEQGRV----KCARYWPTVRYNEAKkvgdriYGHISVAVCSG
. || ||..  . ..  . |.   |.       . ||| || |.   |.  .||.  ..|. .      ||.| |.   .| |      .. ..|  .| 
ddyiHAnrvt.c.pnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelk......fkgltvkCksk

EQHPGYILTHIRLRKGKEEQL-LRHYWFQNWPDHGVPsaEGAHQVIAMMQNVRafCeeqRQGPPIVHCSAGIGRTGTFIAIDQAVRCLE-ETGEVDCLQI
|.. . .  .. .. ..||.. . |.....| .  |.  |    .....|.|.  .   .. | ||||  || |  .. ||. .   .   .|.|   ..
ekeddvetRelvvkfddeeeftvtHsllkgWnklnvq..edtktllsliqkvk..a...sktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledv

VANMRKHRGGMVQHPQQYEFI
. ..||.|  ........ |.
lkalrkqralaitsalelafv

0049260 (Phosphotyrosine protein) phosphatases II 41-234 4.6e-36 119.2 In-house 7-142 (152) alignment
Range on Protein: 41-234
Range on HMM: 7-142/152.0
QPREYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWptvryneakkvgdriyghisvavcsgeqhpgyilthirlrkgkeeqllrHY
.|.|.||. ||..||.. ||||..  .  .||| |  .| |..||..|.                                                 .|
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.................................................qy

WFQNWPDHGVPSAEGAHQVIAMMQNVRafcEEQRQGPPIVHCSAGIGRTGTFIAIDQAVrcleetGEVDCLQIVANMRKHRGGMVQHPQQYEFI
 . .|||||||. .   . .  . . .    ....|| .||||||.|||||..|..           |. ...|| .|..| |.|..|.|..|.
lhlpwpDhgvpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfl

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 43-234 3.9e-25 83.2 In-house 5-196 (199) alignment
Range on Protein: 43-234
Range on HMM: 5-196/199.0
REYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRyneakkVGDRIYGHISVAVCSGEQHPGYILTHIRLRKGK----EEQLLR
| |||.  || .|.  ||.|||   |  |||      .  .  . ||||.        |   || .||.. .   .| | .| . | .        . . 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywptte......sgtgkygslsvttktittkpdytitaliltnnttappstreis

HYWFQNWPDHGVPSAEGAHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQAVRCLEE--TGEVDCLQIVANMRKHRGGMVQHPQQYEFI
|| |  | ..  |        .   ..|    |.... | ||||| | | || |.|.|  ||  ||  |  || ...   .|. | |..   |.|.||
hyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 43-234 4.2e-25 83.1 In-house 4-195 (198) alignment
Range on Protein: 43-234
Range on HMM: 4-195/198.0
REYIAAMGPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTVRyneakkVGDRIYGHISVAVCSGEQHPGYILTHIRLRKGK----EEQLLR
| |||.  || .|.  ||.|||   |  |||      .  .  . ||||.        |   || .||.. .   .| | .| . | .        . . 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywptte......sgtgkygslsvttktittkpdytitaliltnnttappstreis

HYWFQNWPDHGVPSAEGAHQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQAVRCLEE--TGEVDCLQIVANMRKHRGGMVQHPQQYEFI
|| |  | ..  |        .   ..|    |.... | ||||| | | || |.|.|  ||  ||  |  || ...   .|. | |..   |.|.||
hyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 50-233 1.7e-18 61.1 In-house 98-279 (302) alignment
Range on Protein: 50-233
Range on HMM: 98-279/302.0
GPLDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvRYNEAKKVGDRIYGHISVAVCSG--EQHPGYILTHIRLRKGK----EEQLLRHYWFQ
 |  .|.| .| ..   .   .|  . ..|..  ||| |. . . ..  | |      .||           .. |  . ..  |     .. .    | 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysd.kvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

NWPDHGVPSAegAHQVIAMMQnvraFCEEQRQGpPIVHCSAGIGRTGTFIAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEF
 ||||| |    |.. . ...    |||  ..   .||||||.|||||..||   .    .    | |.||  .|. | | ||. ||  .
awpdhGapke..aytaldilk....fcesykkn.vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy

subfamily_hpo-7_pd Subfamily hpo-7 52-233 3.3e-17 57.3 In-house 43-218 (263) alignment
Range on Protein: 52-233
Range on HMM: 43-218/263.0
LDNTIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryneaKKVGDRIYGHISVAvCSGEQHpGYILTHIRLRK----GKEEQLLRHYWFQNWPD
| .||..|.... . |.  .|| . . |.|..|| .|.|.      .| . ... ...|. ..  |.   .|  . | .     |. . ..|| .. |..
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPl......ekdekqklanvnvc.ttkvqs.dvllktlellstlgeKkkthtvkhysykgWie

HGVPSA-EGAHQVIAMMQNVRAFceeqrqgppIVHCSAGIGRTGTFIAIDQAVR----CLE--ETGEVDCLQIVANMRKHRGGMVQHPQQYEF
.  |   .   ... . .| .           .||||.||||.  |  .... .     |.  .|.|.| |... ..|..| . .. | |  |
kndpelareilnilkvarnsksl.........vvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 55-233 1e-19 65.7 In-house 40-212 (255) alignment
Range on Protein: 55-233
Range on HMM: 40-212/255.0
TIEAFWRMVWMVKSPAIVMTTPMMEQGRVKCARYWPTvryneaKKVGDRIYGHISVAVCSgeQHPGYILT--HIRLR--KGKEEQLLRHYWFQNWPDHGV
|...|.... . |.  .|| . . |.|..|| .|.|.      .| . ... ...|..         .|   .| .   . |. . ..|| .. |...  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfpl......ekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWiekna

PsaEGAHQVIAMMQNVRafceEQRqgPPIVHCSAGIGRTGTFIAIDQAVR----CLE--ETGEVDCLQIVANMRKHRGGMVQHPQQYEF
|  | |...  ... ||    . .  . .||||.||||. .|. .. . .     |.  ||.|.| |... ..|..| . .. | |  |
P..elareilnilkvvr....dsk..svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf

0048076 (Phosphotyrosine protein) phosphatases II 129-234 6.3e-22 73.2 In-house 39-135 (145) alignment
Range on Protein: 129-234
Range on HMM: 39-135/145.0
RKGKEEQLLRHYWFQNWPDHGVPSA-EGAHQVIAMMQNVRafcEEqrQGPPIVHCSAGIGRTGTFIAIDQAVRcleetGEVDCLQIVANMRKHRGGMVQH
 .  .|.|  .|.. .|||||||.  |   ..........   .|   || .||||||.|||||..|..   .       |.  .... .|..| |.|..
elellerlgiqylylpwpDhgvpdllellleflefieeal...ke..ggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpn

PQQYEFI
|.|..|.
pgqlrfl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 130-234 2.2e-22 74.0 In-house 84-186 (440) alignment
Range on Protein: 130-234
Range on HMM: 84-186/440.0
KGKEEQLLRHYWFQNWPDHGVPSAEGahQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQ
.| | . |..| .| |||.|||   |   |. |.|.|    |.  .|| .|||||| ||||  ||.|  .|  . . ..| . .. .||. |  ||| |.
ngiesrtlkqyhyqgwpdkgvpkfag..pvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpe

QYEFI
|| |.
qyafv

0048179 (Phosphotyrosine protein) phosphatases II 135-234 2.3e-21 71.4 In-house 47-137 (144) alignment
Range on Protein: 135-234
Range on HMM: 47-137/144.0
QLLRHYWFQNWPDHGVPSA-EGAHQVIAMMQNVRAfceeqRQGPPIVHCSAGIGRTGTFIAIDQAVrcleETGeVDCLQIVANMRKHRGGMVQHPQQYEF
.   .|.. .|||||||.  |   ...........     . || .||||||.|||||..|..  .    . | ..  ...| .|..| |.|..|.|..|
regiqylhlpwpDhgvpdllellleflefieeale.....eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrf

I
.
L

PTPc_DSPc_SM00012 137-234 3.9e-32 106.0 In-house 2-99 (105) alignment
Range on Protein: 137-234
Range on HMM: 2-99/105.0
LRHYWFQNWPDHGVPSAEgaHQVIAMMQNVRAFCEEQR-QGPPIVHCSAGIGRTGTFIAIDQAVRCLEET-GEVDCLQIVANMRKHRGGMVQHPQQYEFI
..||.. .|||||||.    . .. ....|. . ...  ..| .||||||.||||||.|.| ... ||.. .||| .|||  .||.| ||||  .|| |.
vkhyhytgwpdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl





subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 137-234 1.7e-12 41.8 In-house 217-336 (350) alignment
Range on Protein: 137-234
Range on HMM: 217-336/350.0
LRHYWFQNWPDHGV--------PSAEGAHQVIAmMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQAVR---CLEETG----EV-------DC-LQI
. .  ..||.| ..        .. |   ..|    . . . ...|. | .||||||.|||||....|. .     ||..     ..       |   .|
vyqlqvknWkDlslllnPesilqalevkndlid.dlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VANMRKHRGGMVQHPQQYEFI
| ..|| |  |||  .|. ||
vnelrkqrismvqnldqfifi

PTEN_1 137-194 1.8e-07 26.2 In-house 94-149 (196) alignment
Range on Protein: 137-194
Range on HMM: 94-149/196.0
LRHYWFQNWPDHGVPSAEGAHQVIAMMQNVRAFCEEqrQGPPIVHCSAGIGRTGTFIA
   |.   ..|||.|| .  . ... . . .  ...  ..  .||| ||.||.|| .|
gveylhfpieDhgapslselfdicksfiewllsdpn..gnvVlVHCkaGlgRsGtvva

0038934 (Phosphotyrosine protein) phosphatases II 138-233 2.6e-11 39.0 In-house 81-168 (194) alignment
Range on Protein: 138-233
Range on HMM: 81-168/194.0
RHYWFQnWPDH-GVPSAEGAHQVIAMMqnvRAFCEEQRQGPPIVHCSAGIGRTGTFIAidqavRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEF
... .. .||.  ||| |  .. . ..     | .|. .|   ||| ||.|||||..|     . | ..   .  . .| .|  |.|........| 
eylklp.fpddgtvPsleillrfldlv...deflnedpggvvaVHCkaGlgRtGtlva.....aYLiyrlgmsaeeAialfrekRpgaipnqdylea

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 140-234 3.1e-12 40.5 In-house 186-277 (302) alignment
Range on Protein: 140-234
Range on HMM: 186-277/302.0
YWFQNWPDHGVPsaEGAHQVIAMMQNVraFC-EEQRQGPPIVHCSAGIGRTGTFIAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
| ..||... ||  .   ..|. ...|  |  ... . . ..    |.|| |.|..  .|| .|..  |.   .||...|. |  .|.  .|| ..
yvltnWkqkkvp..vkyaeliktaakv..fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvsl

subfamily_PTPDC1_pd Subfamily PTPDC1 140-233 4e-08 27.9 In-house 86-167 (182) alignment
Range on Protein: 140-233
Range on HMM: 86-167/182.0
YWFqNWPDHGVPSAEGAHQVIAMMQNVrafCEEQRQGppiVHCSAGIGRTGTFIAIdqavrCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEF
| |  |.|.||.| | . ... ... .   ..|.. .   ||| || ||||  ||       |  . ...  . .  .|..|   .|  .| |.
ynf.gwkDygvasleriLdivkvvafa...lqegkva...vhChaGlGrtGvliac.....ylvyakrltaekaiklvrskrpksiqtreqvel

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 142-234 2.3e-13 44.4 In-house 197-282 (310) alignment
Range on Protein: 142-234
Range on HMM: 197-282/310.0
FQNWPDHGVPSaEGAHQViamMQNVRAfceEQRQGPPIVHCSAGIGRTGTFIAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
. |||| |||  |  | |    | . |   . |.|| .||||||..|... .|.. ..  |..  .||  .......|.|   .| . || .|
wpnwpdrgvpd.ekchtv...pqrlla...qvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqylii

subfamily_PTEN_pd Subfamily PTEN 147-233 1.1e-07 27.0 In-house 89-171 (184) alignment
Range on Protein: 147-233
Range on HMM: 89-171/184.0
DHGVPSAEgahQVIAMMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQAVRCLEETGEvDCLQIVANMRKHRGGMVQHPQQYEF
||  |. |    . ......... ||...   .||| || ||||. |.     ..| |. | . |.. |..| . .  |. | |  .
Dhnppple...lleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekae.ealelfaeaRtknkkgvtiPsqrRY

subfamily_CDC14_pd Subfamily CDC14 161-230 9.4e-08 26.2 In-house 250-313 (328) alignment
Range on Protein: 161-230
Range on HMM: 250-313/328.0
AMMQNVRAFCEEQrQGPPIVHCSAGIGRTGTFIAIdqavrCLEETGEVDCLQIVANMRKHRGGMVQHPQQ
|....  . .|.  .|  .||| ||.|||||.||       | .. ..   ...| .|  | |.|  |||
aivkkfleiaeka.eGaiavhCkaGLGrtGtLiac.....ylmkhyrftaaeaiawlricrPGsvigpqq

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 162-206 1.7e-08 28.2 In-house 252-296 (349) alignment
Range on Protein: 162-206
Range on HMM: 252-296/349.0
MMQNVRAFCEEQRQGPPIVHCSAGIGRTGTFIAIDQAVRCLEETG
  .. | . ....  . .|||||| ||||... .|  .  || . 
ddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplq

subfamily_CG42327_pd Subfamily CG42327 172-234 1.1e-17 58.7 In-house 244-307 (319) alignment
Range on Protein: 172-234
Range on HMM: 244-307/319.0
EQRQGPPIVHCSAGIGRTGTFIAIDQAVRCLEET-GEVDCLQIVANMRKHRGGMVQHPQQYEFI
...||| .|||| |.||||. || | |.| |||.   ||  |.|  .|. |.  |.  .|||||
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefi

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 179-234 8.6e-11 36.0 In-house 1-56 (69) alignment
Range on Protein: 179-234
Range on HMM: 1-56/69.0
IVHCSAGIGRTGTFIAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.||||.| |||||||||   .  .     || .  |  ||| |  ||    .| ||
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfi

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 179-234 1.1e-10 35.7 In-house 2-57 (69) alignment
Range on Protein: 179-234
Range on HMM: 2-57/69.0
IVHCSAGIGRTGTFIAIDQAVRCLEETGEVDCLQIVANMRKHRGGMVQHPQQYEFI
.||||.| |||||||||   .  .     || .  |  ||| |  ||   ..| ||
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifi