Gene MbrePTP-sf4-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily MbrePTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP050_AA protein Get Run
MbreP050_AA_4336-4609 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Kringle Kringle domain 375-448 1.5e-23 69.3 Pfam-A 4-76 (79) alignment
Range on Protein: 375-448
Range on HMM: 4-76/79.0
DDGdnANYRGQINKTSSGKTCLPWSSSVAQA-NLVTPELYPNADLRHNYCRNPDGERTAWCFVEGTANAFEFCGV
..|   .|||....| ||..|. |.|..... .  |.| ...|.|..||||||||....||... ..  .|.| .
gnG..esYrGtvsttesgaeCqaWdselpkkhkkytaekkkaakLeenyCRNPdgdekpwCytkdpklrveyCsi

DAP10 DAP10 membrane protein 4106-4148 6.8e-06 12.3 Pfam-A 24-66 (79) alignment
Range on Protein: 4106-4148
Range on HMM: 24-66/79.0
STGSSGAAGMSLIVGPVVAVAVIVLLVVLVVVLRRRKRRQQTH
|    |.  . |. | | | ||. ||.| || .  | |.. . 
scsGcGplslpllaGlvaadavvsllivgvvfvcarlrsrpaq

CAP_GLY CAP-Gly domain 4233-4298 4.9e-15 41.6 Pfam-A 1-69 (69) alignment
Range on Protein: 4233-4298
Range on HMM: 1-69/69.0
VGSRVYV--LGYGWGTLRYFGLHA-TKPGARCGVELDTANGLNNGTVDGYWYFAAAPRHGILCDPRKVK
||.|| |       ||.|| |    .|.|  .||||| ..| |.|.|.|  ||   |..|. ..| .|.
vgkrvevdpekerrGtvryvGpvptfksgiwvGveldeprGkndGsvgGvrYFeckpkrGvFvkperve

subfamily_PTPN14_pd Subfamily PTPN14 4327-4610 5.9e-63 207.6 In-house 7-298 (300) alignment
Range on Protein: 4327-4610
Range on HMM: 7-298/300.0
KGKDVRQAQLDHLTEQRKeAANTYDSIFRERQGGSFSSSR--RNSTKNRYTDILAYDDTRVKLRRGI-TGSDYINANYVTFPNEEAPFYFICAQGPTSQT
. || |  .|..  |. |     |. | ..|. . .|...   |  |||. |.| |.|.||.|     . ..||||  .  .   .   .| ||||  .|
atkdkrakilekkleegk.vfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPlelt

VDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQgGLKTPSFVVEFVSQTSDDPYDrVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVP-DVD
| |.||..||..|..|||... .|||. |.  |.|....   ||  |    |..   .  |  . || |.| | ...|.| | |.||  ||||||| ||.
vqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkles.kkktvefgkfkvttkfsedsd.svittglklkhlpskeertvwhlqytDWpdhgvPeDvk

RFLALIDQVESLRAAHPRNM-------YTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKA
 ||  ...|.|.| .  ...         |||||||.|||||.. .  ..| |   .  .   .|..|||||  ||||| ||.| .....  || 
gflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn

subfamily_PTPN23_pd Subfamily PTPN23 4331-4610 9.7e-58 190.2 In-house 6-282 (288) alignment
Range on Protein: 4331-4610
Range on HMM: 6-282/288.0
VRQAQLDHLTEQRKEAANTYDSIFRERQGGSFSSSRRNSTKNRYTDILAYDDTRVKLRrgITGSDYINANYVTFPNEEAPfYFICAQGPTSQTVDDHWQL
.....||  |.  |. ..  ..  .| .. | . ....|.|||..||| || .|||||   .  ||||| .|      .|  ||..|.|  .|. | |..
lqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlm

IWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLKTPSFVVEFVSQTSDDPYDRviltTELTLIHRLTNERRHVTHVQYLGWPDHGVPD-VDRFLALID
..|. ..||||. . .| |. |.. |||..     | . . |   |... ... .     .|.| .. ... ..|.|.|.  ||..|||.  . .|...|
vyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethve....rvlkletldadavksvshlqltsWpelGvPasPetllqfld

QVESLRAAHPRNMYT--LVHCSAGIGRTGVVVQT-MAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKA
.|||   |. |.. |  .||||||.|||||.     |. .. ... ...   ....|||||   ||. .|..|.. ||| . . 
evesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr

0045450 (Phosphotyrosine protein) phosphatases II 4336-4605 2.1e-70 233.2 In-house 23-301 (307) alignment
Range on Protein: 4336-4605
Range on HMM: 23-301/307.0
LDHLTEQRKEAANTYDSIFRERQGGSFSSSRRNSTKNRYTDILAYDDTRVKLRRGI---TGSDYINANYVTF------PNEEAPFYFICAQGPTSQTVDD
||.||  .||    ..   .     |....  | .||||.|||.||.|||||        .||||||.||..      .    .  ||..|||...||.|
ldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetved

HWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSdQGGLKTPSFVVEFVSQTSDDPYDRVILTTELTlihRLTNERRHVTHVQYLGWPDHGVP-DVDRFL
.|...||..|.||||. .| |.|| |||.|||.. .. |    |.|...| . .| | .  |. . .   . |.| |.||| .|.|||||||| ... .|
FwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdl...dgtgesrtvthfhytgwpdhgvppsfeell

ALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVVVQTMAMLAILRRKRI---PEAAAILRHLREQRARLVQTLQQYEFCFTAVL
..|..|.. ....|..  .|||||||.||||...    ||  |..  .   . .  ....|||||   ||...||.|.  |.|
dfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall

subfamily_PTPRN_pd Subfamily PTPRN 4337-4608 3.4e-44 145.7 In-house 23-292 (297) alignment
Range on Protein: 4337-4608
Range on HMM: 23-292/297.0
DHLTEQRKeAANTYDSIFR---ERQGGSFSSSRRNSTKNRYTDILAYDDTRVKLRRG--ITGSDYINANYVTFPNEEAPFYfICAQGPTSQTVDDHWQLI
|||... .  .. .... .   | .  . ... .| .|||....|.||..||||..    . ||||||  ..  .  || | | .||| ..|| | ||..
dhlknkdr.lekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapay.iatqgplastvadfwqmv

WENDVRVIVMVAKLQEDGRSKCAPYWPssDQGGLKTPSFVVEFVSQT--SDDpydrvILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDRFL-ALI
||. | |||....|.|.| ..|. |||  |.|      . |..||.   .||      |   . |    |.| | ||   .| ||..|||   . |  . 
weqGvvvivnltrleeegvkqckrywp..deGsevyhiyevhlvsehiwcdd.....ylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefr

DQVEslRAAHPRNMYTLVHCSAGIGRTGVVVQTMAMLA-ILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKL
 .|.  ..   |    .||||.| ||||| .    .|. .|.  .  . || | |||.||. ||.| .|.||..|||  ..
rkvn..ksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 4338-4610 3e-148 487.5 In-house 1-297 (297) alignment
Range on Protein: 4338-4610
Range on HMM: 1-297/297.0
HLTEQRKEAANTYDSIFRERQGGSFSSSRRNST--KNRYTDILAYDDTRVKLRRGITGSDYINANYVTFPNEEAPFYFICAQGPTSQTVDDHWQLIWEND
.|.|.|||.....|....|..|.||||..|||.  ||||.||||.|||||||.|.||..|||||.||.||.|||....|.||||.|.||||.|.|..|.|
rlredrkeleaekdllldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqd

VRVIVMVAKLQEDGRSKCAPYWPSSDQGGLKTPSFVVEFVSQTSDDpYDRVILtTELTLIHRltNERRHVTHVQYLGWPDHGVP----DVDRF-------
|||||||||||||||.||||||||..|..||....||||.|.|||. .||||| |||.||.|  .|.|.|.|||.|.|||||||    |..||       
vrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsde.fdrvil.telqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcsc

-------LALID--------QVESLRAAHPRNMYTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
       |||..        |.|||||..|||.|.|||||||.||.||||.....||.||.||||..||||..||||||||||||.|.|....|||.|||
ciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkklk

A
.
e

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 4338-4609 3e-58 192.2 In-house 9-277 (281) alignment
Range on Protein: 4338-4609
Range on HMM: 9-277/281.0
HLTEQRKEAANTYDSIFR-E-RQGGSFSSSRRNSTKNRYTDILAYDDTRVKL--RRGITGSDYINANYVtfPNEEAPFYFICAQGPTSQTVDDHWQLIWE
. ... .  ...|...   . ..  . | .  | .||||..| ||| ||||.      . .||||||.|  |  . .  .| .|||  ..... ||..||
lsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfv..pgykgekeyiatqgPvPaslvafWqmvwe

NDVRVIVMVAKLQEDGRSKCAPYWPsSDQGGLKTPSFVVEFVSQTSDDPYdrviLTTELTLiHRLTNERRHVTHVQYLGWPDHGVPDVD-RFLALIDQVE
..|..||||..  | |. ||  |||  |.  ||   ..|.......   |    .. ...| .| ..| |.|....|. |||||||.    .|   ..|.
qkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekaty....ierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevl

SLRAAHpRNMYTLVHCSAGIGRTGVVVQTMAMLAIL-RRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
.|.  . ...  ..|||||.||||. .    ..  . ....  .  |....||..|  .|||. |||| . |||  |.
kltekk.tkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 4342-4606 2.1e-62 205.8 In-house 19-277 (288) alignment
Range on Protein: 4342-4606
Range on HMM: 19-277/288.0
QRKEAANTYDSI--FRERQGGSFSSSRRNSTKNRYTDILAYDDTRVKLRR--GITGSDYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLIWENDVR
.|..  . |.|.  . . . .. ..  .| .|||| .||.|| .||||.     .|.|||||.|.   ...    .|..|||  .||.| |.|..||.. 
nrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkk..kyiatqgPladtvndfWelvyenkts

VIVMVAKLQEDGRSKCAPYWPSSDQGGlKTPSFVVEFVSQTSDDPY-DRVILTTeltlihrLTNERRHVTHVQYLGWPDHGVPDVDR-FLALIDQVESLR
 |||...| |.|..||  |||..|.   .  |. |. |..   . .  | .|          .......|. |||.|||||||.  . .|.|..||.   
tivmltelveggktkCeeYWPdadkpk.nyGsvtvtlveskeledfvlrkllle.......kkkteleitqyqylaWpdhgvPeskapllellrqvkvan

AAHprNMYTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
 |       .||||||.||||. .   |..  ....   . |... .||.||| |||||.||||.. ..| 
qad..tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls

subfamily_PTPN9_pd Subfamily PTPN9 4342-4605 1.7e-59 196.3 In-house 14-287 (297) alignment
Range on Protein: 4342-4605
Range on HMM: 14-287/297.0
QRKEAANTYDSIFRERQGGSFSSS--RRNSTKNRYTDILAYDDTRVKLR--RGITGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVR
...   . |  | .|   | |  |  | |..||||||.| ||.|||.|    . . |||||||.|   ...    || .|||  .||.|.|...||..|.
gkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkka..fiatqGplkktvsdfWrmvWeqevl

VIVMVAKLQEDGRSKCAPYWPSSDQGGLKTPSFVVEFVSQTSDDPYDRviltTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVD-RFLALIDQVESLR-
||||.... | || ||. |||....   .  .. |. |.. . . |      . |.. .  |.| |.||| |.|.|||.|||.    .| ....| . . 
vivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykv....rvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqa

----------AAHPRNMYTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVL
          . ||..   .|||||||||||  .     |. |...   .    ...||.|||  .|| .|||||. |||
lavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavl

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 4342-4611 1.8e-52 173.4 In-house 20-286 (305) alignment
Range on Protein: 4342-4611
Range on HMM: 20-286/305.0
QRKEAANTYDSIFRERQGGSFSSSRRNSTKNRYTDILAYDDTRVKLRRGITG--SDYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLIWENDVRVI
. |.  . |.|. .| .     ..  | .|||...|  .|| |..|.   .   ||||||.||   ...    .| ||||  .||.| |.||.|  |..|
sdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkk..kyivaqgPlkntvadfWrliveekvsti

VMVAKLQEDGRSKCAPYWPSSDQGGLKTPSFVVEFVSQTSDDPYdrviLTTELTLI-HRLTNERRHVTHVQYLGWPDHGVPDVD-RFLALIDQVESlRAA
||..||.|.|..||  ||| | .   .  .|.||  |...   |    .. .|..  ..  .| | |.. |   |||||||.    .| ||..|.  .  
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdy....ieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqk.dqk

HPRNMYTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKAA
. ...  |||||||.||||| .    .|  |..  . . . .|..||..|  .||||.|| |.. |.   ... 
kdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 4344-4609 2.9e-34 113.1 In-house 15-294 (301) alignment
Range on Protein: 4344-4609
Range on HMM: 15-294/301.0
KEAANTYDSIFRERQ-GGSFSSSRRNSTKNRYTDILAYDDTRVKLRRG----ITGSDYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLIWENDVRV
.. .. |... ....   . . | .|.. ||. .|  ||| |. |.      ..  .||||.|.   .|.    || ||||  .|. | |.|||.. .  
nkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekk..kfiaaqgpmkktlvdfWrliwqekpvs

IVMVAKLQEDGRSKCAPYWPSSDQGGLKTPSFVVEFVSQTSD-DPYDRVIL----------TTELTLIHRLTNERRHVTHVQYLGWPDHGV-PDVDRFLA
||||..|.|. .|||  |||.|..   .   | |..|...   |   | .            .| ..  . ... ..|. .|   ||..|| ..    | 
ivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLq

LIDQVeSLRAAHPRNMYTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
 ||.|   |   .     .||||....|.|| .     |   ..  . .   . . .| ..   |.||.|| . . ..   |.
viddv.ihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 4345-4403 5.4e-06 20.5 In-house 24-82 (95) alignment
Range on Protein: 4345-4403
Range on HMM: 24-82/95.0
EAANTYDSIFRErQGG--SFSSSRRNSTKNRYTDILAYDDTRVKLRRgITGSDYINANYVT
|  | . ||     |   .  ||  |  |||. .|. || ||| |      |||||| .| 
efdnefksismt.sgapytvgsseanipknrflnifpydatrvvltt.krdsdyinacfvd

subfamily_PTPN3_pd Subfamily PTPN3 4348-4606 6.1e-68 223.8 In-house 19-273 (280) alignment
Range on Protein: 4348-4606
Range on HMM: 19-273/280.0
NTYDSIFRERQGGSFSSSRR--NSTKNRYTDILAYDDTRVKLRRGITgsDYINANYVTFPNEE--APFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVA
 ... ..| ..| . | .|.  | .|||| |||.||.|||||. . |  |||||||| .  .   .   .| .||| ..|. | ||..||.....|||..
aqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlt

KLQEDGRSKCAPYWPSsDQGGLKTPSFVVEFVSQtsddPYDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDV-DRFLALIDQVESLRAAHprNM
 | |.|| ||  |||.  .  |.  .| |.  ..      .. ... ||.| .. |.|.|.....||| ||||||||  . || ....|..||...  ..
tlverGrvkChqyWPe.tedeleygefsvkceke....detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgk..ee

YTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
 ..||||||||||||..     ||.. ...     .|.|..|.||| |||| .||.|   |.|.
PvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk

subfamily_PTPRK_pd Subfamily PTPRK 4348-4606 1.7e-55 183.0 In-house 26-275 (314) alignment
Range on Protein: 4348-4606
Range on HMM: 26-275/314.0
NTYDSIFRErqgGSFSSSRRNSTKNRYTDILAYDDTRVKLRR--GITGSDYINANYVtfPNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKL
. |.|.|        .    | .|||..|||||| .||.|    | . ||||||...     . |  || .|||  .|| | |.|.....   |||...|
eeyeslfeg...wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaali..dsykrpaafivtqgPlqetvkdfWrlvydencasivmltel

QEDGRSKCAPYWPSSDQGglkTPSFVVEFVSQTSDDpyDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDR-FLALIDQVESLRAAhpRNMYT
.| || ||  |||   .       . ||.|. . .   . |. .  .. ..|  .|.| | ..|.||||||.||   . .|.|. .|.. ..   ..  .
vevgrvkClkyWPedtev...ygdikvelvetella..elvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGri

LVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
.|||||| ||||. .    .| ...|... .   . . ||...  .|.| .|| |.. ..| 
vvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 4349-4609 5.8e-44 145.1 In-house 28-284 (290) alignment
Range on Protein: 4349-4609
Range on HMM: 28-284/290.0
TYDSiFRERQGGSFSSSRRNSTKNRYTDILAYDDTRVKLRRGITGSD----YINANYVT-FPNEEApfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVA
. || . . .      .  |...||...|. ||| |. ||.     |    |||| |.  . ....   .| .|||.|.|. | |.|||...| .|||. 
mlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkq...yiatqgpvsntlvdFWkliwqekvtiivmlt

KLQEDGRSKCAPYWPSSDQGGlkTPSFVVEFVSQTSDDPYDRVILttELTLIHRLtNERRHVTHVQYLGWPDHG-VPDVDRFLALIDQVESLRAaHPRNM
. .|.|. ||  |||.||.       | .. ..... . | .  |  |..  .   .....||. |   |...| |..    | .| ...  .  .. | 
niieegkvkCqqYWpdsdtka..ygefsikllneetlneyierkl..evknknsa.gakqsvtqyqitnwdstgkvtnpqtillvieemyktqr.krgnt

YTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
  .||||...||..| . ..  .   . .   .  ..|...| |.  .||| |||.. |. ||  |.
sivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld

0039614 (Phosphotyrosine protein) phosphatases II 4350-4607 1.9e-71 236.3 In-house 38-288 (297) alignment
Range on Protein: 4350-4607
Range on HMM: 38-288/297.0
YDSIFRERQGGSFSSSRRNSTKNRYTDILAYDDTRVKLRRGI---TGSDYINANYVTFPNEeAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQ
. .. .     |.. .  | .||||.|||.||..||||        .||||||.||....   .  ||..|||...||.|.|...||..|.||||. || 
feellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydl.ltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklv

EDGRsKCAPYWPSSDQgglKTPSFVVEFVSQTSddpyDRVILTTELTLIHrlTNERRHVTHVQYLGWPDHGVP-DVDRFLALIDQVESLRAAHPRNMYTL
|.|| |||.|||.. .   .   |.|.... .     .  . ...|.. .  ..| |.|||.||.|||||||| ... .| ....|.. .|. |..  .|
elgr.kcaqywpeegg...tygdftvtllkveh....ldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvl

VHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAK
||||||.||||...    ||  |.... . .  ....|||||   |||..||.|.. |.|  
VHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel

subfamily_Ptp69D_pd Subfamily Ptp69D 4350-4607 6.7e-56 184.7 In-house 28-285 (307) alignment
Range on Protein: 4350-4607
Range on HMM: 28-285/307.0
YDSIF--RERQGGSFSSSRRNSTKNRYTDILAYDDTRVKLRR--GITGSDYINANYVTFPNEEapFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKL
|...      .  ..|    |  |||| || |.|.|||||..  |   ||||||...   .|.  . ||.||.|  .|..| |..|.| .| .|||...|
yekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykek..kkfiaaqdPveatigDfWRmiaeqevtlivmlsnl

QEDGRSKCAPYWPSSDQGGLKtpSFVVEFVSQTSDDPYD-RVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDR-FLALIDQVESLRAAHprNMY
.|  | ||| |||  |.      . .|..||. . . |  | .  ..        ...|.|.  .|.||.|  ||.| |  | ||.||..|   .  .  
teknrkkcakYWpiedevqyg..dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..rsP

TLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAK
 .|||||| ||.|..|    .|  |.     .  .. ..||.||  ||| |.||.|.. |.|  
ivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 4350-4608 6.4e-43 141.7 In-house 15-266 (283) alignment
Range on Protein: 4350-4608
Range on HMM: 15-266/283.0
YDSIFRERQGGSFSSSRRNSTKNRYTDILAYDDTRVKLRRGITgsDYINANYVTF-PNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQED
.. .    .    .|...| .|||. .|...|  ||.|.      ||||| ...   ...    .| ||.|  .|| | |........  |||..|||||
lkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqed

GRSKCAPYWPSsdQGGLKTPSFVVEFVSQTSDDPYDRVILTTELTlihRLTNERRHVTHVQYLGWPDHGVPDVDRFLALIDQVESLRAAHPRNmYTLVHC
 | ||. |||.  .|  .   | |    .|. . . .  |.         ...   ..| |. .| . |   .   |  ...| ||.  ...    .|||
lrikCsqyWPk..rGsedyGeftvtlrkettsnsfiikelllrvn...ssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkg.PivvhC

SAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKL
|.|||||.| .  .| .  .. . . .  |... .||||  .||||.|| .  ..|| . 
stgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqa

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 4352-4611 2.6e-49 162.5 In-house 28-280 (287) alignment
Range on Protein: 4352-4611
Range on HMM: 28-280/287.0
SIFRER----QggsfsssrrnSTKNRYTDILAYDDTRVKL-RRGITGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQ
 .|..     .            ||||.|.| .||||| |   |  ||||||||||.  ...    ||.|||| . || | |....|. . .......  
atfkaaeelaa..........vkknryadvlPiddtrvllsaegelGsdyinanyvasytddea..fiaaqgPiaatvrdfwravletrsasvitmtrev

EDGRSKCAPYWPSSdQGGLKTPSFVVEFVSQTSDDPYdrvILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDV----DRFLALI-DQVESLRAAHPrN
|..| ||  |||   .  ..   . |  ....  .|      .  | ||.  |.| | |  ...| |||....       ||   . ...|  | |    
eearlkcykywPer.evPmrvGGysvvlldydikePe...ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardase.v

MYTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKAA
   .||...||||.|....|....  |      ..||.. .|||.|| |||.  |. . . |. .  |. 
GPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn

subfamily_PTPRB_pd Subfamily PTPRB 4356-4609 2.8e-61 202.1 In-house 39-286 (293) alignment
Range on Protein: 4356-4609
Range on HMM: 39-286/293.0
ERQGGSFSSSRRNSTKNRYTDILAYDDTRVKL--RRGITGSDYINANYVtfPNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKC
. |  ..... .|..|||||.||.|| .||||   .. .|||||||||.  |. ..|  || .|||  .|||| |...||. ...|||. .| | |. ||
kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyi..pgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkC

APYWPSSDQGgLKTPSFVVEFVSQTSDDPYdrviLTTELTLIHrlTNERRHVTHVQYLGWPDHGVPDV-DRFLALIDQVESLRAAHPRNMYTLVHCSAGI
  |||. ..      .  |..|.... . .     . ||.. .  ..|.|.|.. ... |||||||.  . .|... .|..    . ..  ..||||||.
eeYWPadeep.vlyGdikvtlvaeeeledw....virelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGv

GRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
||||. .    .|  .... . . ..|. .|||.|. |||| .|| |  ..||. |.
GRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr

subfamily_PTPN13_pd Subfamily PTPN13 4359-4610 1.4e-61 203.2 In-house 28-271 (273) alignment
Range on Protein: 4359-4610
Range on HMM: 28-271/273.0
GGSFSSSRRNSTKNRYTDILAYDDTRVKLRRGITgsdYINANYVTFPNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWP
  . . ...| .|||| ..| ||.|||||    .   ||||...  | ..  . .| .|||  .||.| ||..|| ...||.||.. .|.|. ||  |||
tcevgkkkenkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP

SSDQGGLKTPS-FVVEFVSQTSDDPYDrvilTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDrfLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGV
.| .  ||  . . || . ..  | .       .|....  ..| |.|.|...  |||||||     . |.  |  .|  .  .   .|||||||||.|.
esknkklkvsnrlevellkvqkldgfv....vralavkdsesgesrevahlnfvkwPdhgvPssa..aellqfvaevrrlqtdagPivvhcsaGiGrsGt

VVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKA
..   ..| .. |..  .   |.|.|||||  .||| .|| |.. |.|  || 
litidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks

0050432 (Phosphotyrosine protein) phosphatases II 4361-4610 9.3e-77 253.7 In-house 61-301 (308) alignment
Range on Protein: 4361-4610
Range on HMM: 61-301/308.0
SFSSSRRNSTKNRYTDILAYDDTRVKLrrGiTGSDYINANYVTFPNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSS
|...  .| .||||.|||.|| .||||  .  |||||||.||....   |  ||..|||...||.|.|...||..||||||. ||.|.|| |||.|||..
svallpenkdkNrykdilpydhsRVkl..d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwple

DQ-GGLKTPSFVVEFVSQTSddpyDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPD-VDRFLALIDQVESLRaahpRNMYTLVHCSAGIGRTGVV
 . | |.   |.|...|...    .  . ...|.| .  ..| |.||| .|..|||||||. .. .|.....|.. .    ..  ..||||||.||||..
lgggsleygkftvtllseev....lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl....pggpivVHCsaGvGRtGtf

VQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKA
.    .|  |.... . .  ....|||||.  |||..||.|.. |.|  || 
ialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl

0051299 (Phosphotyrosine protein) phosphatases II 4361-4606 5.4e-74 244.6 In-house 42-284 (288) alignment
Range on Protein: 4361-4606
Range on HMM: 42-284/288.0
SFSSSRRNSTKNRYTDILAYDDTRVKLR--RGITGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWP
|...   | .||||.|||.||..||||.   |. |||||||.|....| .    ||..|||...||.|.|...||..||||||. ||.|.|| |||.|||
saallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk..fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwp

SsdQGGLKTPSFVVEFVSQTSDDPYDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPD-VDRFLALIDQVESLRAahPRNMYTLVHCSAGIGRTGV
.  .| |.   ..|...| ...| |    |. . . ... ..| |.||| .|..|||||||| .. .|... .| . .|  ...  ..||||||.||||.
l..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..sgggpvvVHCsaGvgRtgt

VVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
..    .|  |.... ...  ....|||||  .|||..||.|.. |.| 
fialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 4361-4611 9.6e-55 180.9 In-house 49-293 (298) alignment
Range on Protein: 4361-4611
Range on HMM: 49-293/298.0
SFSSSRRNSTKNRYTDILAYDDTRVKLRR--GITGSDYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWP
. .....|  ||||.||.|.| .|| |..  .   |||||| ..   ...    || .|.|  .|| | |....|.|. .|||. .|.| .. |.  |||
evarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn..afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywP

SSDQggLKTPSFVVEFVSQTSddpYDRVIlTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDR-FLALIDQVESlRAAHPRNMYTLVHCSAGIGRTGV
.. .   .  .. |.  |. .   .  .| ...|.. .. ....|.| ....  |||.||| . .  |.|...|.     .  |   .|.||||.||.| 
degk..etygeitvsllskee...fadli.vrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGt

VVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKAA
 .   ..|  .....  .   ... ||..|. .||| .|| |...|||  |.. 
fiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf

subfamily_PTPRG_pd Subfamily PTPRG 4361-4610 1.6e-53 176.8 In-house 40-289 (563) alignment
Range on Protein: 4361-4610
Range on HMM: 40-289/563.0
SFSSSRRNSTKNRYTDILAYDDTRVKLRR--GITGS-DYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYW
..|. . |  ||||..|.||| .||||.   |. .. |||||||.   . .    || .|||  .|.|| |..|||. | .|||...|.|.|| ||  ||
ehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkska..fiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYW

PSsdQGGLKTPSFVVEFVSQTSDDPYD-RVILTTELTLIHRLT-NERRHVTHVQYLGWPDHGVPDVDRFlALIDQVESLRAAHPRNMYTLVHCSAGIGRT
|.  .. ..  .. |  ...     |  | .   .| | .    .. ..|.. .|  |||||||.   .  ||  . | .| .     ..||||||.|||
Pk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslp.vLifvkkssaankaeaGPivvHcsaGvgrt

GVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKA
|. .   ..|  .... . .   .|.|.| ||  ||||  || | . |.|  ...
GtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 4361-4606 3.1e-53 176.1 In-house 54-289 (319) alignment
Range on Protein: 4361-4606
Range on HMM: 54-289/319.0
SFSSSRRNSTKNRYTDILAYDDTRVKLRR--GITGSDYINANYVTFPNeeAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAklqedgRSKCAPYWP
.|.   .|  |||...|||.| ..|||.|  |. .|||||| .||      .  .| ||||   |..| |..||| ..  ||...      . ||. |||
tfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyq..rkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywp

SSDQGGLKTPSFVVEFVSQTSDdpydRVILTTELTLIHRLTnERRHVTHVQYLGWPDHGVPDVD-RFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGV
   .   .     |. | .|..     |.   ||.   . . . |..|   .|||||.||||    .. |...|. |.     .   .||||||.|||||
lkivikeerfkvkvdsveetae....yvvrdielsedgkek.dirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGv

VVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
 .   ..|  .....  .   ..| ||.|| .||| | || |...|.| 
yivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 4361-4600 6.9e-31 101.9 In-house 45-282 (310) alignment
Range on Protein: 4361-4600
Range on HMM: 45-282/310.0
SFSSSRRNSTKNRYTDILAYDDTRVKLRRGIT-GSDYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPS
.. . ...  ||||.|..  |..||||.   .   ||| ||||      .   |||.|||  .|. | |..|...    |... |  |.|| ||  ||||
tyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrs..tficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps

SDQGGLKTPsFVVEFVSQTSDDpYDRVILT-----TELTLIHRLTN-ERRHVTHVQYLGWPDHGVPDVDRFlalidQVESLRAAHPRNMYTLVHCSAGIG
            |  .|..|.. .. . |.      .. .  . .| .   |. ...  ||| ||||          |     |  |    .||||||..
lgvtetygc.irvtnlsessee.feicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekch.....tvpqrllaqvrhgpcvvhcsagkd

RTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFC
|..|||.    .  |.|    .|  .  .|. .||  .||  || . 
rlyvvvalklkidkldrglkvdaeevktellksraiciqtelqylii

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 4361-4603 4.1e-24 80.0 In-house 26-254 (267) alignment
Range on Protein: 4361-4603
Range on HMM: 26-254/267.0
SFSSSRRNSTKNRYTDILAYDDTRVKLRRgiTGSDYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKcapYWPSS
| | .  |  .||. | | |||||| ||   .  .|||| ||   . .    ||  |.| ..|. |....| ...| |||.. |  .|   .   .||  
sqsiaeknqernrlddnlpyddtrvilrt..keeeyinasyvegyktkn..afivtqdplkntitdfltvihdqkvpvivlltkvftdnirl...fwPPk

DQGGLKTPSFVVEFVSQTSDDPYDrvILTTELtlihRLTNERRH-VTHVQYLGWPDHGvpDVDRFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVVV
     |   ..||.  .  .. |.  |.| ||    .. ||  | ||   |  |      .   .|  .  . .       |   .|.||.|.||.|  .
mgqakkyqdltvehslekeendyq..iitlel....kfknesahnvtlyyykkwnint..nnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtfl

QTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTA
   ..|  ...  . .    ||..|.||  ||.|...| ..   
vidsqleraktegvsdifdflrkirsqriglvdtkeryiyihel

0036941 (Phosphotyrosine protein) phosphatases II 4362-4610 3.9e-74 244.9 In-house 33-279 (297) alignment
Range on Protein: 4362-4610
Range on HMM: 33-279/297.0
FSSSRRNSTKNRYTDILAYDDTRVKLrRGiTGSDYINANYVTFPneEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSD
 ... .| .||||.|||.||.|||||  .  |||||||.||...  . .. ||..|||...||.|.|...||..|.||||. .| |.|| |||.|||.  
vallpenleknRykdilpydhtRVkl.dd.egsdYinAsyvdgy..dlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywplee

QGGLKTPSFVVEFVSQTSDdpYDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPD-VDRFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVVVQ
.. |.   |.|...| ...  ..  . ...|.. .  ..| |.||| .|.||||||||. .. .|..|..|.. ... |..  .|||||||.||.|... 
gesltygdftvtllsvevv..llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfia

TMAMLAILR---RKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKA
   ||  |.   . . .    ....|||||.  ||||.||.|.  |.|  || 
adlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk

0046845 (Phosphotyrosine protein) phosphatases II 4362-4610 8.2e-74 243.8 In-house 22-276 (284) alignment
Range on Protein: 4362-4610
Range on HMM: 22-276/284.0
FSSSRRNSTKNRYTDILAYDDTRVKLRRGITG---SDYINANYVTFPNE---EAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAP
..    | .||||.|||.||..||||..   .   ||||||.||....      .  ||..|||...||.|.|...||..||||||. .| |.|| |||.
vallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaq

YWPSSdQGGLKTPSFVVEFVSQTSddpyDRVILTTELTLIH-RLTNERRHVTHVQYLGWPDHGVP-DVDRFLALIDQVESLRAAHPRNMYTLVHCSAGIG
|||.. .. |.   | |...| .     .  . ...|.| .  .|.| |.||| .|..||||||| ... .|.....|..|. ..|..  ..||||||.|
Ywple.gevltygdftvtllseev....kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvg

RTGVVVQTMAMLAILRRKR---IPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKA
|||...  . .|  |....    . .  ....|||||   ||||.||.|.. |.|  || 
RtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl

0047943 (Phosphotyrosine protein) phosphatases II 4362-4606 3.4e-73 241.8 In-house 32-270 (273) alignment
Range on Protein: 4362-4606
Range on HMM: 32-270/273.0
FSSSRRNSTKNRYTDILAYDDTRVKLrrGITGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSD
...  .| .||||.|||.||..||||  |  |||||||.||...| .    ||..|||...||.|.|...||..||||||. .|.|.|| |||.|||.. 
vallpenkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrk..fiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleg

QG-GLKTPSFVVEFVSQTSddpyDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVP-DVDRFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVVV
..  |.   | |...|...    .  . ...|.| .  |.| |.|||..|.|||||||| ... .| .|..|.. ..| |.|  ..||||||.||||...
gelsltygkftvtllseet....kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfi

QTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
    .|  |.... . .  ....||.||   |||..||.|.  |.| 
aldllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle

0040438 (Phosphotyrosine protein) phosphatases II 4362-4609 1.7e-71 236.4 In-house 37-277 (317) alignment
Range on Protein: 4362-4609
Range on HMM: 37-277/317.0
FSSSRRNSTKNRYTDILAYDDTRVKLRR--GITGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPS
...   |  ||||.||| ||..||||    |. .||||||.||..||.     ||..|||...||.|.|...||..|.||||. .| |.|| |||.|||.
vaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk..fIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl

sdQGGLKTPSFVVEFVSQTSddpyDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVP-DVDRFLALIDQVESLRAahPRNMYTLVHCSAGIGRTGVV
  .. |.   |.|...| .     .  |  ..|.. .  ..| |.||| .|.|||||||| . | .|.....|.. ..  ...  .|||||||.||||..
..getltygdftvtllseee....lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGtf

VQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
.    ||  |.... . .  ....|||||.  |||..||.|. .|.|  ||
iaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk

0043336 (Phosphotyrosine protein) phosphatases II 4362-4605 1.1e-68 227.1 In-house 39-274 (278) alignment
Range on Protein: 4362-4605
Range on HMM: 39-274/278.0
FSSSRRNSTKNRYTDILAYDDTRVKLRR--GITGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPs
.. .  | .||||.|||.|| .||||    |  .||||||.||...|      ||..|||...||.|.|...||..|..|||. .| |.|| |||.||| 
iallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk..fiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.

sdQGGLKTPSFVVEFVSQTSddpyDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVP-DVDRFLALIDQVESLRAahPRNMYTLVHCSAGIGRTGVV
  .| |.   |.|.......    .  . .. |.. .. ..| |.|||..|||||||||| ... .| .. .| . ..  ..|  .|||||||.||||..
..ggsltygdftvtllkeeh....lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..dsngpvlVHCsaGvgRTGtf

VQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVL
.    .|  |.. . . .  ....|||||.  |||..||.|.. |.|
ialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall

subfamily_PTPRD_pd Subfamily PTPRD 4362-4610 2.2e-68 226.3 In-house 42-283 (564) alignment
Range on Protein: 4362-4610
Range on HMM: 42-283/564.0
FSSSRRNSTKNRYTDILAYDDTRVKL--RRGITGSDYINANYVTFPNeeAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPS
 ..   |  |||| .|.||| .||.|   .|  |||||||...   .  ..  .| .|||...|..| |...||.....|||. ||.| |. ||. |||.
aankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr..krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPe

SdQgGLKTPSFVVEFVSQTSDDPYdrviLTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDV-DRFLALIDQVESLRaaHPRNMYTLVHCSAGIGRTGVV
. .   .  ...|......    |      ....| .  ..| | |.. ..  |||||||.    .|.||..|..|.  .| .  ..||||||.||||. 
k.g.tetygeltVtleeeeelady....eirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln..epdagPivVhCSaGVGRTGtf

VQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKA
.   |||  .. ..  .   ....||.||  .||| .|| |...|.|  |..
ividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac

subfamily_PTPN12_pd Subfamily PTPN12 4362-4607 8.1e-60 197.1 In-house 34-276 (290) alignment
Range on Protein: 4362-4607
Range on HMM: 34-276/290.0
FSSSRRNSTKNRYTDILAYDDTRVKLR--RGITGSDYINANYVTFPNEEapFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPS
 ... .| .|||| ||| || .||.|.  ..  ||||||||..  ....    .| |||| ..|.||.|..||| .|...||. .. | |. ||. |||.
agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegk..leyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpe

SDQGGLKTPSFVVEFVSQtsdDPYDRVILTTELTLIHRltNERRHVTHVQYLGWPDHGVPD-VDRFLALIDQVESLRAAHprNMYTLVHCSAGIGRTGVV
. .  |.. .| |.  ..   .  |  .|   |.. ..  .|.|.|.  .|  |||||||  ... |.||..|..|. ..  ..  .||||||.||||..
egeeelefgefevtleee...kavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqese..daPlvvhCsaGvGrtGti

VQTMAMLAILRRKRIPEAAA---ILRHLREQRARLVQTLQQYEFCFTAVLAK
.    .  .|....|||      ....||.||| |||| .|||. . ||.  
iaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 4362-4606 1.4e-52 173.9 In-house 19-253 (284) alignment
Range on Protein: 4362-4606
Range on HMM: 19-253/284.0
FSSSRRNSTKNRYTDILAYDDTRVKLRR--GITGSDYINANYVTFPNeeAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAklqedgRSKCAPYWPS
|.   .|  |||...|||.| ..|||.|  |. .|||||| ..|      .  .| .|||   |..| |..||| ..  ||...      . ||. ||| 
fanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyq..rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

SDQGGLKTPSFVVEFVSQTSDdpydRVILTTELTLIHRLTnERRHVTHVQYLGWPDHGVPDVD-RFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVV
  .   .     |. |.....     |.   ||.   . . . |...   .|||||.||||    ...|...|. |.  .  .   .||||||.||||| 
kivikeerfkvkvdsveesee....yvvrdielsedgkek.dirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvy

VQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
.   ..|  .....  .   ..| ||.|| .||| | || |...|.| 
ivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_PTPRA_pd Subfamily PTPRA 4362-4606 3e-52 172.5 In-house 52-293 (330) alignment
Range on Protein: 4362-4606
Range on HMM: 52-293/330.0
FSSSRRNSTKNRYTDILAYDDTRVKL--RRGITGSDYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPs
 .|   |  |||. .|| || .|| |  ..|.  |||||| ..   .|    .|| |||| ..||.| |..||| .   |||...|.|  ..||| ||| 
laskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekd..kfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP.

sDQGGLKTPSFVVEFVSQTSDDPYD-RVILTTELTLIHRlTNERRHVTHVQYLGWPDHGVPDVD-RFLALIDQVESLRAAHPRnmYTLVHCSAGIGRTGV
 |.| .      ||   .|    |  | .| ..|.   |  .. | |. . . .||| |||      | |. .|..|.  .       ||||||.|||| 
.deGlvtyGnirvevedetvlvdytvrkflvqqlpdatr.ekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag..pivvhcsaGvGrtGt

VVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
 .   |.|. .. .|. .   ....|| ||...|||..||||.. ..| 
fivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle

subfamily_PTPN1_pd Subfamily PTPN1 4362-4608 8.7e-50 164.1 In-house 26-271 (290) alignment
Range on Protein: 4362-4608
Range on HMM: 26-271/290.0
FSSSRRNSTKNRYTDILAYDDTRVKLRRGITgsDYINANYVTFPneEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSD
 .   .| ..||| |.  || .|.||.|. .  |||||. | ..  ||   .| .||| ..|||  ||..||.. . .||. |. | .. ||| |||. .
eaklpenrnlnryrdvspydhsrikleradn..dyinaslvele..eakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqge

Q-GGLKTP--SFVVEFVSQTSDDPYDRVIltteLTLIHRLTNERRHVTHVQYLGWPDHGVPDV-DRFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGV
.   |.    .. |...|. . . | . .    | |  . |.| |...|  |. ||| |||.    || .. .| .  .  .    ...||||||||.| 
eekellledtklkvkliseerksyytvrl....lelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

VVQTMAMLAILRRKRIPEA---AAILRHLREQRARLVQTLQQYEFCFTAVLAKL
..   ..|. . .|   ..      | .||..|  |.|| .| .| ..|.|   
fclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGa

DSPc_SM00195 4363-4607 2.9e-72 238.5 In-house 21-261 (263) alignment
Range on Protein: 4363-4607
Range on HMM: 21-261/263.0
SSSRRNSTKNRYTDILAYDDTRVKLRRGI--TGSDYINANYVTFPneEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSS
.   .|..||||..|| ||.||||| .    .|||||||||....  . .  .|..|||...||.|.|...||..|..|||. . .|.|. ||. |||..
aekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpee

DQGGLKTPSFVVEFVSQTSDDpydRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVP-DVDRFLALIDQVESLRAAHprNMYTLVHCSAGIGRTGVVV
 .|  .  .. |..|......   . | ...|.| .  ..| | ||..|| .||||||| . . .|.|. .|.. .     .  ..||||||.||||..|
sggketfgkisvklvevekkk...deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgRtgtfv

QTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAK
 .  .|  |...  ..  .|...||.||...||||.|| |. .|.|. 
tidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

PTPc_SM00194 4363-4607 2.9e-72 238.5 In-house 21-261 (263) alignment
Range on Protein: 4363-4607
Range on HMM: 21-261/263.0
SSSRRNSTKNRYTDILAYDDTRVKLRRGI--TGSDYINANYVTFPneEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSS
.   .|..||||..|| ||.||||| .    .|||||||||....  . .  .|..|||...||.|.|...||..|..|||. . .|.|. ||. |||..
aekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpee

DQGGLKTPSFVVEFVSQTSDDpydRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVP-DVDRFLALIDQVESLRAAHprNMYTLVHCSAGIGRTGVVV
 .|  .  .. |..|......   . | ...|.| .  ..| | ||..|| .||||||| . . .|.|. .|.. .     .  ..||||||.||||..|
sggketfgkisvklvevekkk...deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgRtgtfv

QTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAK
 .  .|  |...  ..  .|...||.||...||||.|| |. .|.|. 
tidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 4363-4612 2.7e-62 205.7 In-house 41-284 (318) alignment
Range on Protein: 4363-4612
Range on HMM: 41-284/318.0
SSSRRNSTKNRYTDILAYDDTRVKLR--RGITGSDYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSS
| .  | .||||..|||||.|||||.   | .|||||||||.   ...    .| ||.| ..|..| |...|| . .||||.....| |. |.. ||||.
slepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkk..ayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk

dqGGLKTPSFVVEFVSQTSDDPYdrvILtTELTLIHRLTNERRHVTHVQYLGWPDHGVPD-VDRFLALIDQVESLRAaHPRNMYTLVHCSAGIGRTGVVV
  |  .  . |||  .... . |   .|  |... .. ..| |.|   .|  |||.|||. .  .|.|. ||..  . .. .  ..||||||.||||| .
..gsrsygklvvelkeevelsdy...vl.refkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqq.ksgagpivvhCsaGvGrtGvfi

QTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKAAD
   ..|  ..   . .   . ..|||||  .||| .||||.....|  |.. |
avdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 4363-4612 1.5e-54 180.2 In-house 43-287 (319) alignment
Range on Protein: 4363-4612
Range on HMM: 43-287/319.0
SSSRRNSTKNRYTDILAYDDTRVKLR--RGITGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSS
.|  .|..||||..||||| |||.|    |. |||||||...   .|.    || .|.| ..|..| |...||... ..||..||.| .. |.  |||. 
askeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerek..fiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpee

D--QGGlktpSFVVEFVSQTSDDPYdrvIlTTELTLiHRLTNER--RHVTHVQYLGWPDHGVPDVDrfLALIDQVESLRAAHPR--NMYTLVHCSAGIGR
.  ..|     ..|.  ..   . |   |   .|.| .....|   |.|.| ||. ||||.||.    ..|.| .. .| .. .  .    ||||||.||
nfeeyG....rlivtleeeeeledy...i.irklkl.nkkssevetRevkhfqyteWpdhdvPeka..tslldllkrirksrektqsgPivvhCsaGvGR

TGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKAAD
||  .   |||  ...  . .   . ..|| ||  .||. .||.|.. |.|. ..| |
tGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 4363-4605 4e-43 142.2 In-house 50-286 (305) alignment
Range on Protein: 4363-4605
Range on HMM: 50-286/305.0
SSSRRNSTKNRYTDILAYDDTRVKLRRGItGSDYINANYVTFPNEEApFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQ
 |.  . |||||.|. . | . ||| .    |||| ||||  |       |||||||  ||.|. | .. .| |  |||..|  | |. ||| ||| .  
qsadiaitknryqdvpcqdqsavkldkps.psdyihanyvgcpmipe.krficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqg

GGLKT-PSFVVEFVSQTSDDPYDRVILTTELTLIHRlTNERRHVTHVQYLGWPDHGVPDVDrflalIDQVESLRAAHPRNMYTLVHCSAGIGRTGVVVQT
  |.     ||| || .     |  |  | | | .   ...  | |.|.  ||| ||| .      .  .| | |    ..  .||||||||||| .|  
eklelksgivvenvsgskpmerdaeiqitllnltys.gdqkmsvrhlqwtewpdrgvppck.....ltslellsairgskvpivvhcsagigrtgtivai

MAML-AILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVL
  .|  |   |. |    ... ||.|||  .|.  || |    .|
eyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvml

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 4363-4611 1.6e-42 140.5 In-house 42-281 (287) alignment
Range on Protein: 4363-4611
Range on HMM: 42-281/287.0
SSSRRNSTKNRYTDILAYDDTRVKLRrgITGSDYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQ
. . .|  |||.|.|| .|. || |.   .  ||||| ..   .|.    || |..| ..|. . |.||... | .|||.....|. ...|  |||... 
niasqnkdknRltqilvpdnyrvllk..gehpdyinavfidgykekk..afiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks

ggLKTPSFVVEFVSQTSDDPYdrVILTTELTLIHRlTNERRHVTHVQYLGWPDHG-VPDVDRFLALIDQVESlRAAHPRNMYTLVHCSAGIGRTGVVVQT
  .    . .|.....  . |  .. . |..  .. ......|.  |.  |...| |..    | .|..       .. |   .||||...||... .  
..vvlGeyniellneevnagy..ierklevknknk.agdkqqvkqyqitnWdstgkvtepqtillvieemyk.tqrkrgntsivvhCsdtvGrsamfcaa

MAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKAA
   .   ..  . .   .|.. | |.   ||| .||.| . .||. |.. 
attinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsf

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 4363-4610 3.8e-34 112.9 In-house 43-281 (439) alignment
Range on Protein: 4363-4610
Range on HMM: 43-281/439.0
SSSRRNSTKNRYTDILAYDDTRVKL--RRGITGSDYINANYVTFPNEeaPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRskcapYWPSS
 .   . ||||| |. |.| ||| |    |.  | ||||||.    .  .  .| .|||. .|.|| |.|..|. .  |||...| |  .     ||||.
aaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyd..dklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsd

DQGGLKtpSFVVEfVSQTSDDPyDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDRFLalIDQVESLRAAHPRNMY--TLVHCSAGIGRTGVV
..        .|  | .  . | . ||    .   .  |.  | | ...|. |||. ||    ..  .| . .. .|  .. |   .||||||.|||| .
aevcyg..diavr.vdrnielp.nyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashv..ldflrainsandkeeygpvvvhcsagvGrtGti

VQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKA
.     |  |. .   .   |.. ||.|| ..||.| || | . |||  .. 
ialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivy

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 4363-4461 1.2e-25 85.0 In-house 42-154 (350) alignment
Range on Protein: 4363-4461
Range on HMM: 42-154/350.0
SSSRRNSTKNRYTDILAYDDTRVKLRR----------GITGSDYINANYVTFP----NEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQED
|.  .  .||||..|| |. .||||..           . ..|||||||.  .    . .. | .| .|.|. .|||| ...| .|.|.||.......| 
seGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvel

GRSKCAPYWPSSD
.. ||  ||.  .
nlekcyrYWqegs

subfamily_egg_pd Subfamily egg 4363-4605 1e-23 78.5 In-house 35-267 (307) alignment
Range on Protein: 4363-4605
Range on HMM: 35-267/307.0
SSSRRNSTKNRYTDILAYDDTRVKL--RRGITGSDYINANYVTfpNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDgrSKCAPYWPSS
. |  | .| |   .   | .||||  |||    |.| ||.|    .     ||.|| |   |||| |.......|. |||..  .|    .|  ||| .
aasdnnlekarskrvhckdssrvklelrrGqylddfihanrvk..Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpka

DQGGLKT--PSFVVEFVSQtsDDPYDRVILTTELTLIHRLtNERRHVTHVQYlgwpdhgvpDVDRFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVV
..  |.|   |. .| .    |.  | .   |.| |.    .| |.. | |.         ||.    .   .. || .      ..|..  |. .....
esdslvtvpGslrienlkv..dskadplfrvtklklvGgd.deerflehwqg.........dvnnssdvysplrvlrklrnlskpvvvqdilGvskaatl

VQT-MAMLAILRRkRIPEA--AAILRHLREQRARLVQTLQQYEFCFTAVL
|   .|.| .||   |           || .|   |..  .| | .  ||
vaieiallsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvl

0040439 (Phosphotyrosine protein) phosphatases II 4364-4605 1.8e-65 216.3 In-house 7-243 (249) alignment
Range on Protein: 4364-4605
Range on HMM: 7-243/249.0
SSRRNSTKNRYTDILAYDDTRVKLR--RGITGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSsd
.   |  ||||.|||.|| .||||   .|  .||||||.|.....      ||..|||...||.|.|...||....||||. .|.| || |||.|||.  
llpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr..fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..

QGGLKTPSFVVEFVSQTSDDPydrvILTTELTLIHRLTNERRHVTHVQYLGWPDHGVP-DVDRFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVVVQ
.| |.   |.|...| .. |     . ...|.| .  ..| |.|.|.||..||||||| ... .|..|..|.. ... |..  .|||||||.||||... 
ggsleygdftvtllsvevkdd....ytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

TMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVL
   ||  |....   .  ....||.||   ||...||.|.  |.|
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall

0042113 (Phosphotyrosine protein) phosphatases II 4364-4605 1.4e-64 213.2 In-house 5-240 (245) alignment
Range on Protein: 4364-4605
Range on HMM: 5-240/245.0
SSRRNSTKNRYTDILAYDDTRVKLRRGITG--SDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSsd
.   | .||||.|||.||.|||||    .   ||||||.||....      ||..|||...||.|.|...||.....|||. .. |.|| |||.|||.  
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk..fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

QGGLKTPSFVVEFVSQTSddpyDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPD-VDRFLALIDQVESLRAAhPRNMYTLVHCSAGIGRTGVVVQ
.. |..  |.|...| ..    .  . ...|.. .  ..| |.|.|..||.|||||||| .. .| ... |.. .|. ..|  .|||||||.||||... 
gesltygdftvtllseeh....lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfia

TMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVL
   ||  |.. .   .  ....||.||   |||..||.|.  |.|
aylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall

0037934 (Phosphotyrosine protein) phosphatases II 4364-4605 1.4e-62 206.8 In-house 6-239 (243) alignment
Range on Protein: 4364-4605
Range on HMM: 6-239/243.0
SSRRNSTKNRYTDILAYDDTRVKLrrgiTGSDYINANYVTFPNeeapfYFICAQGPTSQTVDD----HWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPs
..  | .||||.|||.||..||||     ||||||||... ..     ..|. |||...||.|    .|...||....||||. .|.| || |||.||| 
llpenlsknrysdilpydhsrvkl....egsdyinanliyvtp.....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

sdqGGLKTPSFVVEFVSQTSDDPydrvILTTELTLI-HRLTNERRHVTHVQYLGWPDHGVPD-VDRFLALIDQVESLRAA------HPRNMYTLVHCSAG
   |.     |.|...|... |     .  ..|.|  . |... |.|.|..||.|||||||| .. .|...|.| .   .       ...  .|||||||
...gevtygdftvtllseehldd....ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

IGRTGVVVQTMAMLAILrrkRiPEAAAILRHLREQRAR-LVQTLQQYEFCFTAVL
.||||...    ||  |   .   .  ....|||||    |||..||.|.  |.|
vgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeall

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 4364-4606 1.5e-54 179.8 In-house 16-262 (270) alignment
Range on Protein: 4364-4606
Range on HMM: 16-262/270.0
SSRRNSTKNRYTDILAYDDTRVKLRRG--ITGSDYINANYVTFPNEeAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSD
.  |... |||.|||    |||.| .      . |||||||   .. .. ..|.|.||.  |. ..|..|||. |. |||...|.|.||.||. |||.. 
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdg.ekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaep

QGGLKTPSFVVEFVSQtSdDPYDRVILTTELTLIhRLTNERRHVtHVQYLGWPDHGVPDVDR-------FLALIDQVESLRAAHPRNMYTLVHCSAGIGR
.  .|.    .. ... | .  ..  ..|.|.|  .  .||| | | .|  |||||||  .         |... .|   .  . ..  .|||||||.||
kekvkledgkikvlal.s.eekeegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgR

TGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
||... .  .. .| ...  . .||...||..|  |||. .|||| . ||. 
tGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve

0049772 (Phosphotyrosine protein) phosphatases II 4364-4608 7.2e-41 136.3 In-house 42-280 (314) alignment
Range on Protein: 4364-4608
Range on HMM: 42-280/314.0
SSRRNSTKNRYTDILAYDdTRVKL-RRGITGSDYINANYVTFPneeapFYFICAQGPTSQTVDDH----------WQLI--WENDVRVIVM---------
.  .| .||||.||| .| .||.| . .. |||||||.||  .       ||..|||.. ||.|           |...  ....||.|||         
dlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------VAKLQEDGrskcaPYWPSSDQGGLKtpsfvvefvsqtsDDPYDRVILtteltlihrltneRRHVTHVQYLGWPDHGVPDVDRFLALID
              .| . |     .... .|.  ||             .  ||.  .              |.. .. .. .||...|. . |.....
lsrLdaAlgKtpllildgng.....neptaadlellk.............eelydpelf.............erlgikylripvpDgsaplledfdefle

QVESLraahPRNMYTLVHCSAGIGRTGV-VVqtmaMLAILRRKRIpEAAAILRHLREQRA-----RLVQTLQQYEFCFTAVLAKL
 .|..    ...  .||||.||.||||. ||    .  .... ..  .. .|...|..|      .....|.||||.. |.| .|
fieea....dkggpvlvHCkaGkgRtgtfvv....aaylmkllgv.sleealedvrlkRpinpnpgfieqleqyefilealleyl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 4364-4603 5.9e-39 128.9 In-house 37-272 (307) alignment
Range on Protein: 4364-4603
Range on HMM: 37-272/307.0
SSRRNSTKNRYTDILAYDDTRVKLRRGITGSDYINANYVTFPNeeAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQG
. . |. ||||.|. . | .|. ..     |||| |||.       |  |||||||  .|. . | .. ...|  ..|..|. | .. ||  |||  .  
afsantdknryqdvkcqdkgrivvkfdglasdyihanylgiai..kpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegq

----GLKTPSFVVEFVSQTSDDPYDRVILTTELTLIHrlTNERRHVTHVQYLGWPDHGVPDVDrfLALIDQVESLRAAhprNMYTLVHCSAGIGRTGVVV
    | .. .  |. .      | . .|  |.| .    ... | ..|.|.  |||.|||...  |. |. .|. |     .   .||||||.||.| .|
klvfgeapntisvanlgakklapdedlinvttlkvdw..aqksrtiqhlqwenwpdrgvpqin..ltainlleavryd...tnpvvvhcsaGvGrsGtiv

QT-MAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTA
   . .  ... .   .   ... ||.||   .||  || .    
aislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrv

subfamily_ptpA1_pd Subfamily ptpA1 4364-4567 7.2e-39 128.7 In-house 43-255 (418) alignment
Range on Protein: 4364-4567
Range on HMM: 43-255/418.0
SSRRNSTKNRYTDILAYDDTRVKLRR--GITGSDYINANYVtfpNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSD
  ..|..|||||.||  . |||.|..     |||||||||.   .   |  |||.|||  .|. | |...||| .|.|||...  |. | ||  |||   
dkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyi...dgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqi

QG---------GLKTPSFVVEFVSQTsDDPyDRVILTTELTLIhrLTNERRHVTHVQYLGWPDHGVPDVD-RFLALIDQV----ESLRAAHPRNMYTLVH
 |              .. ||.|    .|| .| |.| .. |   .  | | .|. || ||||| .||    |  |.  .    . .  .  ||.  .||
ggeqfsiygngnevfgtysvelvevi.qdp.ereiitrnirlt..fegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivh

CSAGIGRTGVVVQTMAMLAI
||||.|||| .. .. |.  
csagvgrtgtfctavimmkk

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 4364-4460 1.2e-15 51.7 In-house 44-156 (349) alignment
Range on Protein: 4364-4460
Range on HMM: 44-156/349.0
SSRRNSTKNRYTDILAYDDTRVKLRRGITG----------------SDYINANYVTFPNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQE
.  .  .|||| ||| |. .||||....                   |||||||. ... .. . .|. | |   ||||....|  | |.... . . .|
eGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddke

DGRSKCAPYWPSS
 .  ||  ||   
lslekcdiywqel

0045098 (Phosphotyrosine protein) phosphatases II 4365-4606 1.3e-68 226.7 In-house 30-270 (278) alignment
Range on Protein: 4365-4606
Range on HMM: 30-270/278.0
SRRNSTKNRYTDILAYDDTRVKlrrgitgsDYINANYVTFPneeaPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSsdQGG
 . |  ||||.|||.|| .|||        |||||.|....    |. ||..|||. .||.|.|...||....||||...|.|.|| |||.|||.  .| 
ylgnldknRykdilpydhsrVk........dYINAsyidgy....pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggs

LKTPSFVVEFVSQTSDDPYDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVD---RFLALIDQVESLRA-----------AHPRNMYTLVHCSA
|    |.|...| .  | |  . |. . . ..| ..| |.|||..||.|||||||. .    || |...... ..           .....  .||||||
ltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GIGRTGVVVQTMAMLAILrrKRIPEAAAILRHLREQRAR-LVQTLQQYEFCFTAVLA
|.||||..|  . ||  |  ..   .  ....||.||    ||.|.||.|.. ..| 
GvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyeflle

subfamily_PTPN6_pd Subfamily PTPN6 4365-4609 1.9e-58 192.9 In-house 51-298 (306) alignment
Range on Protein: 4365-4609
Range on HMM: 51-298/306.0
SRRNSTKNRYTDILAYDDTRVKL-RRGITGSDYINANYVTFPNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQG
  .| .||||  || .|.|||.| . ...|||||||||..   ..   ..| .||  ..|| | |...|... |||||. |  | |..|||.|||.. . 
kpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeek

GLkTPSFVVEFVSQTSDDPYDrvilTTELTLIH-RLTNERRHVTHVQYLGWPDHGVP-DVDRFLALIDQVESLRAAHP--RNMYTLVHCSAGIGRTGVVV
   . .  |. ||..| . |.      ||.. . .  .| |.| . ..  ||||||| | . .|.....|.. .      ..  ..||||||||||| ..
ee.yGkisvtnvseksladYi....lRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfi

QTMAMLAILRRKRIPE---AAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
 . ..| ....| .        . . .||||  |||| ||| | ..|. . ..
viDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 4365-4609 5.3e-51 168.3 In-house 41-278 (315) alignment
Range on Protein: 4365-4609
Range on HMM: 41-278/315.0
SRRNSTKNRYTDILAYDDTRVKL--RRGITGSDYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQ
 . | .|||| .|| .| .||||     .  |||||| |.   ...    .|..|||   .||| |.......|  ||||.|.||. . ||. |||  . 
etinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddk..ayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrka

GGLKTPSFVVEFVSQTSDDpyDrvilTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDRflALIDQVESLRAAHPRNMYT-LVHCSAGIGRTGVVVQT
   .  |. || .|  .|   |    ..   |. | ..| | ||  |. .|||.||.      .|.  .  ..| . .. .. |||||||.||||||.  
dsvefGsikvellsleadt..d....gvarklvtrkseesrtvtqfqftewPdkGvdkqts..sllklikevkadngkkefsllvhcsaGvGrtGvvisi

MAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
. ..| ..|.|  .   ... ||..|  |||| ..| | . ||| .|.
devvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 4365-4610 1.8e-49 163.2 In-house 6-244 (250) alignment
Range on Protein: 4365-4610
Range on HMM: 6-244/250.0
SRRNSTKNRYTDILAYDDTRVKLRRGI--TGSDYINANYVTFPNEEapFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSkCAPYWPSSDQ
  .|  ||||.||.|.| .|| | .      |||||| ..   .|.    || .||| ..|. | |....|... .|||...|.| ..  .  |||    
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder..kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

ggLKTPSFVvefVSQTSDDPYDRVIlTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDR-FLALIDQVeslRAAHPR--NMYTLVHCSAGIGRTGVVV
   |  .     ||  |.. .  .. ...| | ..  ...|.| ..... ||| |||.| .  |.|...|   .| ...  |   .|.||||.||.|  .
..ekyGdvt...vsllskeefadyt.krklklskakkaderivrqlhfvvWPdkgvPevatavLellkkv...qasqqqagnaPvivqCsaGvgrsGafi

QTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKA
   |.|  |..... .   ... ||..| . |..|.|| |.....|  |..
aidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 4365-4614 2.9e-45 149.7 In-house 48-290 (297) alignment
Range on Protein: 4365-4614
Range on HMM: 48-290/297.0
SRRNSTKNRYTDILAYDDTRVKLRRGITG--SDYINANYVTFPNEeapfYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRsKCAPYWPSSdq
 . |  |.||..|| ||  ||||.   .   |||.|| .|   ..     .|. | |  .||.| |.......| .|||.....|  . ||| ||. .  
kkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh....rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdk..

GGLKTPSFVVEFVSQTSDdpydRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDRFLALIDQVESLRAAHPRNMY--TLVHCSAGIGRTGVVVQ
|  .  . .|.  | ..     .  .  ||.. .  .  || |   |.. |||. |.  |.  .|.. .. .|  .  |     ||||.||.|||||.. 
gvttfGdvsvvllsvser....eGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvllt

TMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLKAADWR
   ..|  .|.   .   ....||..|  |||| .||.| . |||  | . | |
idsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtr

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 4365-4608 9.6e-38 124.6 In-house 42-236 (392) alignment
Range on Protein: 4365-4608
Range on HMM: 42-236/392.0
SRRNSTKNRYTDILAYDDTRVKL--RRGITGSDYINANYV-TFPNEEApfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGrskcapywpssd
   |  |||| .|| || .||||     |. |||.|| |. .| ||.|   .|..||| . ..|| |.......|  |.||.||.|              
keinlkknryknilpydsarvkleviddipdsdylnasyipsfdneka...yiasqgpnaaslddfwrmvfqenvttiamvtklkegd............

qgglktpsfvvefvsqtsddpydrviltteltlihrLTNERRHVTHVQYLGWPDHGVPDVDRflALIDQVESLRAAHPRNM-YTLVHCSAGIGRTGVVVQ
                                      .. | |.  ..  |||..||      .|.  .. ..| . .     ..|||||.||||||. 
....................................kgddartvaqfhftewPdkdvpkhts..sllkfikevkadfGqythpliihcsagvgrtgvvis

TMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKL
  ...|  .. |. .   ..  .|..|  .||| .|| | . |||  |
idsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 4365-4605 5.3e-33 109.1 In-house 4-237 (239) alignment
Range on Protein: 4365-4605
Range on HMM: 4-237/239.0
SRRNSTKNRYTDILAYDDTRVKLRRGI--TGSDYINANYVTfPNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQ
 | | .||||..|..|| .|| | .      ||||||.|.    . .|  .|..||  . .  | |...|..   ||||.. | |  . ||  ||| |  
krvnkaknryanivtydhsrvvleklsndphsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

gglKTPSFVVEFvsQTSDDPYDRVILTTELTLIHRltNERRHVTHVQYLGWPDHGVPDVDR-FLALIDQVesLRAAHPRNMYTLVHCSAGIGRTGVVVQT
   |   . | .  . ..   | .| |  .. . .   | |.| . ..  |||.|||.     | |  ..   . . |     ..|||||.|||| ..  
...kycnlrvtl..rktevfadyiirtfvmsqvgq..teeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtgaflvi

MAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVL
 |||   ....  .    .. .||.| ..||| .|| | . |||
damlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 4365-4605 6.1e-33 109.0 In-house 5-238 (239) alignment
Range on Protein: 4365-4605
Range on HMM: 5-238/239.0
SRRNSTKNRYTDILAYDDTRVKLRRGI--TGSDYINANYVTfPNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQ
 | | .||||..|..|| .|| | .      ||||||.|.    . .|  .|..||  . .  | |...|..   ||||.. | |  . ||  ||| |  
krvnkaknryanivtydhsrvvleklsndphsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

gglKTPSFVVEFvsQTSDDPYDRVILTTELTLIHRltNERRHVTHVQYLGWPDHGVPDVDR-FLALIDQVesLRAAHPRNMYTLVHCSAGIGRTGVVVQT
   |   . | .  . ..   | .| |  .. . .   | |.| . ..  |||.|||.     | |  ..   . . |     ..|||||.|||| ..  
...kycnlrvtl..rktevfadyiirtfvmsqvgq..teeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtgaflvi

MAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVL
 |||   ....  .    .. .||.| ..||| .|| | . |||
damlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_eak_pd Subfamily eak 4365-4533 2.8e-10 34.1 In-house 47-209 (332) alignment
Range on Protein: 4365-4533
Range on HMM: 47-209/332.0
SRRN--STKNrYTDILAYDDTRVKLRRGITGS-DYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSD
..|     .|   .|. ||   |.|         ||||  . |..      .| .  .  . |   ||.. |.    ||....  | .  |   |.|   
tarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGr..kyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdkt

QGGLKTPSFVVEFVSQtsddpYDRVILTTELtLIHRLTNERRHVTHVQYLGWPDHGVPDVDRFLALIDQVES
.  ||   . ||  .        | || | | |. .  ||  .| | .. || .  .| .. |||| . .  
reelkfGildverkef.....vkrniletrl.lelskGnethrvlhykvfGwtettlpkyedflalrkvmke

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 4366-4609 7.7e-41 135.0 In-house 47-280 (315) alignment
Range on Protein: 4366-4609
Range on HMM: 47-280/315.0
RRNSTKNRYTDILAYDDTRVKL--RRGITGSDYINANYVTFPNeeAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSdqg
  |  |||| .|.||| .||.|       .|||.|||..   |   .  .|.||||  ..|.| |.|..|.|.  |||...| |. ..|.  |||     
ienkqknryiniiaydksrvqlpllendphsdyvnanfidGyn..kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...

glkTPSFVVEFVSQTSDDPYDRVILTTEltlIHRLTNERRHVTHVQYLGWPDHGVPDVD-RFLALIDQVESLRAAHPrnMYTLVHCSAGIGRTGVVVQTM
      .    |.. |.. ....   |         .. |.|  ..|  ||| |||     .. || .|   . .       .||||||.||||  .   
...kviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitld

AMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
|.|  .  ... .   ... .|..| ..||...||.| . |.|  . 
avldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfv

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 4366-4606 1.5e-34 114.6 In-house 46-286 (325) alignment
Range on Protein: 4366-4606
Range on HMM: 46-286/325.0
RRNSTKNRYTDILAYDDTRVKLR--RGITGSDYINANYVTFPNEEApfYFICAQGPTSQTVDDHWQLI--WEndVRVIVMVAKLqEDGRSKCAPYWPSSD
  |  |||. ...|.| .|| |   .  . ||||||.|.    .     |. || | ..|..| |.|.  |.    |.|.. .| . |  .|| |||   
penkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkd..vflaaqaPltatindlWrlvldWr..csvvvvlnel.dlgkdrcavywpkem

QGGLKTPSFVVEFVsqTSDDPYDRVILTTELTliHRLTNERRHVTHVQYLGWPDHGVPDVDRFL----ALIDQV-ESLRAAHPRNMYTLVHCSAGIGRTG
    .  .. |...  | ..  | |    ..        | | |   |. .|.| ||.     |     |...| | ..|        |||||||.||||
gksktfGglevklr..tieeisdyvhrvldvk..qvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtG

VVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
| .   ..|| .  .   .    ...||..|  .|.|  || ....|.  
vfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealve

subfamily_CG7180_pd Subfamily CG7180 4366-4605 5.6e-31 102.3 In-house 40-287 (296) alignment
Range on Protein: 4366-4605
Range on HMM: 40-287/296.0
RRNSTKNRYTDILAYDDTRVKLRR--GITGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRsKCAPYWPSSDqg
  |  |||. ... || .|| |..  |   |||||| ||     ..   .|  ..|. .|||..|.|......  .|...|  .  . ..  |||     
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkke..yivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..

GLKTPSFVVEFVSQTSDDPYDR--VILTTE----LTLIHRLTNERRHVTHVQYLGWPD-HGVPDV-DRFLALIDQVESLRAAH---PRNMYTLVHCSAGI
  .   ..|| |.. .        . || .        .  . | | |...|.  |.  . || .   .. |. .|...|      | .  ..|..| | 
keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGa

GRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVL
.|.|| .   | |  ....   .    .. ||..| .||.. ..| ...  .|
sRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 4366-4604 9.8e-27 88.6 In-house 33-266 (285) alignment
Range on Protein: 4366-4604
Range on HMM: 33-266/285.0
RRNSTKNRYTDILAYDDTRVKLRRgiTGSDYINANYVTFPNEEAPFYfICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGL
  |   |||.|. . ..||| |.      ||| |... .| ..   | | .|||  .|. | |..|... .  ..|.. | | |  ||| |.|      .
eanpdlnryadvrcieetrvvlkn..hdrdyihaswmrmpgkdqsty.ittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

KTPSFVVEFVSqTSDDPYDRVILT-TELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDRflALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVVVQ-TMA
|   . . .     ..     ||    ..     ..|  .. |||   |||.  |.  |   .|.  . ..   |..    ||||||.|||  .|    |
kfgkyeitlte.ckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedar..pmielykwvkkvnpkekpicvhcsagvgrtatfvgidya

MLAILRRKRIpEAAAILRHLREQRARLVQTLQQYEFCFTAV
 . |.    | |   |.| .|  | . ||.  |. | .  .
tirimenpni.emldivremramrfqavqshmqflflyvvl

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 4366-4606 1.5e-17 58.0 In-house 49-283 (302) alignment
Range on Protein: 4366-4606
Range on HMM: 49-283/302.0
RRNSTKNRYTDILAYDDTRVKLRRgiTGSDYINANYVTFPNEEAPFYfiCAQGPTSQTV---DDHWQLIWENDVRVIVMVAKLQEDGRsKCAPYWPSSDQ
..|. ||. .|. ..|...|||    .  .|.||  |. |. . . .   || |.....   .. |...... .  .|.... .|  .     ..|   .
kknlkknqsedvpildsnlvklea..epdsyvnaskvevPeltrsii..laQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

GGLKTPSFVVE--FVSQTSDDPydrVILTTELtLIHRLTNER-RHVTHVQYlgWPDHGVPdvDRFLALIDQVESL-RAAHPRNMYTLVHCSAGIGRTGVV
  ..  .. |    |......      .. |. | .  .|     |.....  |... ||  ... .|| .....     . .  |..    |.|| |..
dykeygkmfvNnrkVekaeeek...tryviEv.lPegcsnsvlanvyvltn..Wkqkkvp..vkyaeliktaakvfakkikadentvivSknGaGRagaf

VQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
.  .. .  | ..  |... |.. .|.||.| |..|.|| . . |.| 
ltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialll

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 4366-4525 5e-11 36.7 In-house 94-242 (244) alignment
Range on Protein: 4366-4525
Range on HMM: 94-242/244.0
RRNSTKNRYTDILAYDDTRVKLRRGITGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRskcapYWPSSDQGGL
  || |||    | .|  || | .|  |  |||| .|      |   .| .| | ..|  | |... |  | |.|..  ..|.       ||| |.    
pnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtae..yiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpdseplew

KTPSFVVefvSQTSDDPYdRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDRFL
      |   . |  | . . | ...| .   . .  . .|  |   ||  |    | |.
yeeditv...tltdrdef.knikasnleiesdmneshqaltmfqisnwpsdgttpndhfi

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 4367-4609 3.1e-51 169.1 In-house 27-269 (274) alignment
Range on Protein: 4367-4609
Range on HMM: 27-269/274.0
RNSTKNRYTDILAYDDTRVKLRRGITGS---DYINANYVTFPNEEAPFyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQG
...|||||..||  . .|| |..  . .   .||||||.  ..||    .. .||| ..||.| |..|....|.||||..||.|  ..||| |.| . . 
gsqtknryktilPnensrvllesessededssyinanyikGydeeska.yvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

GLKT--PSFVVEFVSQTSDDPYDrviLtTELTLIHRLTneRRHVTHVQYLGWPDHGVPD-VDRFLALIDQVESLRAAHPRN-MYTLVHCSAGIGRTGVVV
 ..     . ..... .. . |    . ..|.| .     .|.|.|  |  |||| .|| .. .| |...||. | ..  .   ..|||||||||||. .
eiserygdveikvekiverndys...v.rklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfi

QTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
 .   .  ||.. . .   |  .|| .|  .||| .|||. . |.   ||
aisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 4367-4609 7.7e-51 167.7 In-house 42-277 (515) alignment
Range on Protein: 4367-4609
Range on HMM: 42-277/515.0
RNSTKNRYTDILAYDDTRVKL--RRGITGSDYINANYVT-FPNEEApfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQG
 | .|||| .|| || .||||        |||.|| |.  | |. |   .|..|||   .||| |.|.....|  |.||.||.|. ..||. |||     
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndka...yiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgd

GLKTPSFVVEFVSQTSDDpyDRviLTTELTLIHrlTNERRHVTHVQYLGWPDHGVPDVdrFLALIDQVESLRAAHPRNMYT-LVHCSAGIGRTGVVVQTM
 .|  |. || ||  ..   .   .  .||...   .. | ||  .. .|||.|||      .|.  .  ..| | .  .. ..|||||.||||||.  .
svkfGsikvelvsleact..gg..ikrkltvlk..gddsrtvtqfhfteWPdkGvpkh..tssllklikevkadhgqythpliihcsaGvGrtGvvisid

AMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
 ..|  .  |. .   ... .|..|  |||| .|| | . ||| .|.
svvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 4367-4605 6.9e-42 138.3 In-house 2-236 (237) alignment
Range on Protein: 4367-4605
Range on HMM: 2-236/237.0
RNSTKNRYTDILAYDDTRVKLRRGITGSDYINANYVTFpNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGlk
.|  |||| .| ||| .|| |.   .|||||||.|.    . .|  .|.||||   . || ||..|..   ||||.. | |  . ||  ||||.||    
enkiknrygnivaydhsrvvlkgagsgsdyinatylkg.fdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa..

tpSFVVEFVSQTSDDPYDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDRFLALIDQVESLRAAH-PRNMYTLVHCSAGIGRTGVVVQTMAML
  .. |  || . .. .    . . |.  .   .| | .   |.  |||.|||.    |  . .    |. | ..    ..|||||.||||...   |||
..aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml

AILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVL
   . |.. .    .  . |.|  ..|| .|| | . ..|
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 4367-4606 6.5e-41 135.0 In-house 47-285 (305) alignment
Range on Protein: 4367-4606
Range on HMM: 47-285/305.0
RNSTKNRYTDILAYDDTRVKLrRGITGSDYINANYVTFPNEeaPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLK
... |||| |.   |. |||| .|    .|| ||||. | .  |  |||.| |  .|  | | . ... |  | |. .|.| |  ||. |..| |.  |.
qeagknrykdvgcldnnrvkl.egpwpheyihanyvstptn..pkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

----TPSFVVEFVSQTS---DDPYDRVILTTELTlIHRLTNERRHVTHVQYLGWPDHGVPDVDrfLALidqVESLRAAHPRNMYTLVHCSAGIGRTGVVV
        .| | | ..    .. . ..  |.|. |    .. |.|||  .  ||| |||  |  ||.   .| |  | |    . ||||||||||| ||
feekgqkisvkfessvtlkfrkdakakvtetvlv.iegpgekarkvthyhwidwpdrgvpaad..lai...lellekarpskgpivvhcsagigrtgsvv

QTMAML-AILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
    .|  .|  . | ..  ||...||||   .|| .|| |    .| 
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 4367-4609 2.6e-36 120.1 In-house 42-272 (288) alignment
Range on Protein: 4367-4609
Range on HMM: 42-272/288.0
RNSTKNRYTDILAYDDTRVKLRrgITGSDYINANYVTfpNEEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLK
 |.|..||...   | |||||        ||.|| |.   .. .  .|||| |   |..  |... |.||. |||...| | |. | | |.||      .
anptrdryenlprcditrvkls..ddpdfyiaanvvs..sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

TPSFVVeFVSQTSdDPYDRVILTTeLTLIHRLTNERRHVTHVQYLGWPDHGVPDvdRFLALIDQVESLRAAH-PrnmyTLVHCSAGIGRTGVVVQTMAML
   .    | .   .  |...  . |  |.. ..|.  | .. .| |.|.|||.   .|. .  .| |.. . |     .||.|||.|||| .. .. .|
igrlct.vvkkkr.adidklvkvs.llriskegeekvivkilhlleWdddgvPe..nylsplrllevlkslqkP....ivvhssaGvGrtgtlililial

AILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
  || .       .| .|||.| . .|| .|| . .  || .| 
eslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 4367-4605 1.2e-34 114.3 In-house 36-266 (281) alignment
Range on Protein: 4367-4605
Range on HMM: 36-266/281.0
RNSTKNRYTDILAYDDTRVKLRR---GITGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQG
 |  ||||..| . | .||.|.        .||| |||.  |  .    .| .|||  .|  | |..||...   |||.... |  | ||| |.|   . 
vnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrg..yiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahc

GLKTPSFVVEFVSQTsddpYDRVILTTELTLIHrlTNERRHVTHVQYLGWPDHGVPDVDRFLALIdqvesLRAAHPRNMYTLVHCSAGIGRTGVVVQ-TM
 |.   . |..   |     .. ..|| | | .    | | .||  .  |||  ||.    .  |     ||  . |    ..|||||.||.| ..   .
clqfdklsvsyedst....vnkslvttrlnlsy..egetrlithwlwkewpdwqvpessevmlki.....lrkirarstppvihcsagvgrsgtlmavei

AMLAILRRKRIPEAAAILRHLRE-QRARLVQTLQQYEFCFTAVL
|. .|  .  .|.   |. |||   ||  ||||||| . .  .|
alqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll

Y_phosphatase Protein-tyrosine phosphatase 4368-4605 4.1e-68 224.7 Pfam-A 1-234 (235) alignment
Range on Protein: 4368-4605
Range on HMM: 1-234/235.0
NSTKNRYTDILAYDDTRVKLRRGITGSDYINANYVTFPNEeaPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLKT
|..||||.|||.||.|||||.   . |||||||||.  .|  .. ||..|||...|..|.|...|...|.||||...|.| || |||.|||..... |..
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

PSFVVEFVsqTSDDPYDRVILTTELTLIHRLTN-ERRHVTHVQYLGWPDHGVP-DVDRFLALIDQVESLRaaHPRNMYTLVHCSAGIGRTGVVVQTMAML
 .. || .  ..    .  . ...|.| .. .. |.|.|....| .||||||| ... .| ||..||. .  ....  ..||||||.||||..|  ...|
gdikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

AILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVL
  |.... ..   |...||.||. .||.|.||.|.  |.|
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 4368-4605 4.1e-68 224.7 In-house 1-234 (235) alignment
Range on Protein: 4368-4605
Range on HMM: 1-234/235.0
NSTKNRYTDILAYDDTRVKLRRGITGSDYINANYVTFPNEeaPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLKT
|..||||.|||.||.|||||.   . |||||||||.  .|  .. ||..|||...|..|.|...|...|.||||...|.| || |||.|||..... |..
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

PSFVVEFVsqTSDDPYDRVILTTELTLIHRLTN-ERRHVTHVQYLGWPDHGVP-DVDRFLALIDQVESLRaaHPRNMYTLVHCSAGIGRTGVVVQTMAML
 .. || .  ..    .  . ...|.| .. .. |.|.|....| .||||||| ... .| ||..||. .  ....  ..||||||.||||..|  ...|
gdikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

AILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVL
  |.... ..   |...||.||. .||.|.||.|.  |.|
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

0041856 (Phosphotyrosine protein) phosphatases II 4368-4608 1.9e-43 143.5 In-house 1-171 (182) alignment
Range on Protein: 4368-4608
Range on HMM: 1-171/182.0
NSTKNRYTDILAYDDTRvklrrgitGSDYINANYVTFPNEEAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAklqedgrskCAPYWPssdqgglkt
| .||||.||| || .|        ..||||||.. ..       ||..|||. .|| |......|.....||...         . .|||         
nldknrysdilpydhsr........dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

psfvvefvsqtsddpydrviltteltlihrlTNERRHVTHVQYLGWPDHGVPDVDRFLALIDQVESlraahpRNMYTLVHCSAGIGRTGVVVQTMAMLAI
                               ... |......||.||||||||.| .|..|..|..      ..  .|||||||.||||..|    |.  
...............................ellerlgiqylylpwpDhgvpdldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl

lrrkRiPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKL
    .   .  .....|..|   |.|..|| |.  |.| .|
....g.vsleeavklvrsrRpgmvitpnqyfflqlallell

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 4368-4606 1.3e-39 130.6 In-house 56-281 (290) alignment
Range on Protein: 4368-4606
Range on HMM: 56-281/290.0
NSTKNRYTDILAYDDTRVKLRRGITGsDYINANYVTFPNeeAPfyFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLKT
. .|||| |.   | ||| |. |  | ||. ||||   .  |.  || .||.. .|| | |... ...| .|||. .| |||..||..|.|  .   |  
efkknrykdvvcndktrvilkdGydG.dyvhanyvkGlk..am..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltf

PSFVVefvSQTSDDPYDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDVDrfLALIDQVESLRAAHPRnmyTLVHCSAGIGRTGVVVQTMAMLAI
 .. |     . .|  |  |    |.. .. .     . |..   |||. |.  .  |||.  . .|| |        |||||||||||  |   . | |
Geitv...lcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalst..lallrtlrilrkasGp...vvvhcsaGiGrtGtfvaievglqi

LRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLA
|   .  . . . | ||. |.  ||   ||     ..| 
lldGkeldlldlvralrnsrlnsvqvdiqylalveilld

subfamily_CG42327_pd Subfamily CG42327 4370-4528 1.7e-21 71.2 In-house 30-187 (319) alignment
Range on Protein: 4370-4528
Range on HMM: 30-187/319.0
TKNRYTDILAYDDTRVKLRRGIT--GSDYINANYVTFPNeEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDqGGLKT
 |.|. ...   .||| |.|      . |..|.||  .. .|| ..|.|| .  ..  | |...||.  |||| ...|.| |  .|| |.|... ..  |
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyd.dapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtke.tldnt

PSFVVEFVSQTSDDPYDRVILTTeLtLIHRL-TNERRHVTHVQYlGWPDHGVPDVDR-FLALI
 ..    |.    .  || ...| | |..|.  .| |..||  |  |.. .||  .. ..|..
slyGdilvtlkgrevkdryaist.l.llkrvdkeesrelthywy.kwleaevPaeeaaliaml

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 4371-4609 2.4e-27 90.5 In-house 46-277 (312) alignment
Range on Protein: 4371-4609
Range on HMM: 46-277/312.0
KNRYTDILAYDDTRVKLRRgiTGSDYINANYVTFPNEeaPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWpsSDQG---GLKT
 ||| .|  .|  |  |        || ||.|       |  |.|.|||  .|.   |||        |.... . |||  ||| |   ||      |. 
lnrypniqcwdrgrftlag..denfyihanfvkictk..perfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi..sdivgfvdled

PSFVVEFVSQTSD--DPYDRvILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDV-DRFLALIDQVEslraahPRNMYTLVHCSAGIGRTGVVVQTMAM
     |....        |. |    | .. . | .  .. | |.  |||||.||  |  | |.  |         .   . |||||.|||| ..   .|
hrvyteycteieiggkskdk.ithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk......kdkkpviahcsagvgrtgtlaliesm

LAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTAVLAKLK
.| ||  |  .   ..  || .||| |... || ... .||  | 
iaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 4371-4597 2.8e-24 80.4 In-house 53-270 (301) alignment
Range on Protein: 4371-4597
Range on HMM: 53-270/301.0
KNRYTDILAYDDTRVKLRRGITgSDYINANYVTFPneEAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLKTPSF
|.||  .    .| |..    .    | ||..  .    |  ||..||| ..| .| | ..   ||  |||...  |.  .||. | |.. .  |.   |
khryptvPckPstavevivdGk.rvPihanwipts..GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrf

VVEFVSQTSddPYDRVILTTELTLIHR-LTNERRHVTHVQYLGWPDHGVPDVDrfLALIDQVESLRAAhprNMYTLVHCSAGIGRTGVVVQTMAMLAILR
 .. ... .    .  |   .| .       . | ||| ||  |.|.|||       | | .| .. .   .   .|||||||||.   . |  .   . 
kikiknkel..ilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPksh..aelfdlmelvkks...ekPivvhcsaGiGrsvafigteylareve

RKRIPEAAAILRHLREQRARLVQTLQQY
 ..  | .  |.||||.| . ||| .| 
adptieltealkhlrehrwngvqtnsql

0044763 (Phosphotyrosine protein) phosphatases II 4387-4602 1.1e-29 98.7 In-house 11-165 (178) alignment
Range on Protein: 4387-4602
Range on HMM: 11-165/178.0
LRRGITGSDYINANYVTfpneeaPFYFICAQGPtsqtvDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQgglktpsfvvefvsqtsddpydrv
 ..|. .||||||....      |........|      |...|..|.....||.... .| |. || ||||..                          
nleglersdyinaseil......pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag........................

iltteltlihrltnerrhvTHVQYLGWPDHGVPD-VDRFLALIDQVESLRAahPRNMYTLVHCSAGIGRTGVVVqtmaM----LAIlrrkRIpEAAAILR
                    .......|||||||  . ||.... .|....  ...  .|||||||.||.|..|    .    .      ..  . ....
...................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlv....aaylmkkl....gl.sleeaie

HLREQRArLVQTLQQYEFCFT
..||.|   |..  |....  
lvrerRp.ivpnpgqlrqLye

0046846 (Phosphotyrosine protein) phosphatases II 4388-4605 2.1e-37 123.9 In-house 6-170 (176) alignment
Range on Protein: 4388-4605
Range on HMM: 6-170/176.0
RRGITGSDYINANYVTFPneeapfYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLktpsfvvefvsqtsddpydrvi
.    ..||||||..  .      ..|. |||. .|. | .....|......|.. ...| || ||. |||   . |.                      
lgldldldyinanlilgs......rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

ltteltlihrltnerrhvtHVQYLGWPDHGVPDVDRFLALIDQVESLRAAHprnMYTLVHCSAGIGRTGVVVQTMamlaILRRKRIPEAAAILRHLREQR
                   ....|.|||||||| . .| |...... . ..     .||||||||||||..|       .|....   .  .|...||||
...................qylhlpwpDhgvpdlelllellefirealkeg...gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqR

A-RLVQTLQQYEFCFTAVL
  . ||| .||.|.  ..|
plgavqtpeQyrflyefel

0051429 (Phosphotyrosine protein) phosphatases II 4392-4608 6.1e-41 136.2 In-house 2-225 (272) alignment
Range on Protein: 4392-4608
Range on HMM: 2-225/272.0
TGSDYINANYVTFPneeapF------YFICAQGPTSQTVDDHWQLiWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQ-------GGLKTPSFVVEFVSQT
  |.||||..|  .     .      ......||.  |..| |.| .|.....||.. .. | || || .|||  .         .  |...   .|  .
plsgyiNardvggy.....grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtll

SDDPYDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDvDRFLALIDQVESlraahprNMYTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPE---
|   .. .||.. |  ..  ..| |.|.| .|..|||||||. . .|.|.... .       .   |||||||..|||.||    .|. . .  | .   
seellldyilrellltlllsagearevmhlhytdwpdhgvpq.eallellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYl

-----AAAILRHLREQRARLVQTLQQYEFCFTAVLAKL
     .......||.||.  ||| .||.|.. |.|. |
ltnlyleeaveelraqrpgavqteeqylflyeallell

0036282 (Phosphotyrosine protein) phosphatases II 4393-4601 7.9e-41 135.0 In-house 1-163 (174) alignment
Range on Protein: 4393-4601
Range on HMM: 1-163/174.0
GSDYINANYVTFPNEEApfYFICAQGPTSqtvddHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSsdqgglktpsfvvefvsqtsddpydrvilttel
|||||||... .       ..|. |||..     .|....|......||. ...|.|. ||  |||.                                 
gsdyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................

tlihRLTNERRHVTHVQYLGWPDHGVPDVDRFLALIDQVESLRAAhPRNMYTLVHCSAGIGRTGVVVQTMAMLAILRrKRIPEAAAILRHLREQRARLVQ
    . . ..|.. ...||.||||||||.. .| ....||. ..  ...  .|||||||.||||..|  . ||  |.  .  .| ...| || || . ||
....lredlerlgiqylylpwpDhgvpdlsillefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvq

TLQQYEFCF
| .||.|. 
tpsQyrfly

0043147 (Phosphotyrosine protein) phosphatases II 4393-4601 4.2e-37 122.9 In-house 4-154 (172) alignment
Range on Protein: 4393-4601
Range on HMM: 4-154/172.0
GSDYINANYVTFPNeeAPFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLqedgrskcapywpssdqgglktpsfvvefvsqtsddpydrvilttel
|||||||.|. ..    |  ||. |||.. |..|.|....|.....||.. .|                                               
gsdyinasyldlyy..ipdrfiatqgplrntladfwrmlkelgithivnltel...............................................

tlIHRLTNERRHVTHVQYLGWPDHGVPDVDRFLALIDQVESLRaAHPRNMYTLVHCSAGIGRTGVVVQTMAMLailrrKRIpEAAAILRHLREQRARLVQ
   .  ... |.. ...||.|||||||. . .| .......|  |  ..  .|||||||.||||..|    ||     ...  .  .....||.|   ||
..lydpellerlgiqylylpwpDhgvpllellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavq

TLQQYEFCF
. .|| |. 
npsqyrfly

0051082 (Phosphotyrosine protein) phosphatases II 4394-4603 9.3e-29 95.4 In-house 3-148 (151) alignment
Range on Protein: 4394-4603
Range on HMM: 3-148/151.0
SDYINANYVTfPNeeapfyFICAQGPTSqtvdDHWQLIWENDVRVIVMVAKLQEDGrsKCAPYWPSSDqgglktpsfvvefvsqtsddpydrvilttelt
|||||..||| ..      ... .||..    |...|..|.....||.. ...| |  .|. |.|. .                                
sdyinfsyvt.gg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

lihrltnerRHVTHVQYLGWPDHGVPDV-DRFLALIDQVESlraahPRNMYTLVHCSAGIGRTGVVVQTMAMLaiLRrkriPEAAAILRHLREQRARLVQ
         ..|.|...|.|||.|.|.  | .|........     ..|  .|||||||.||||..|  . ||  |.      ....|...|..|  .||
.........ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylml..lg....vsleealeeyrlkrpgvvq

TLQQYEFCFTA
. ||. |.. |
pnqqflfqlfa

0049260 (Phosphotyrosine protein) phosphatases II 4410-4601 4.1e-33 109.6 In-house 8-143 (152) alignment
Range on Protein: 4410-4601
Range on HMM: 8-143/152.0
PFYFICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWpssdqgglktpsfvvefvsqtsddpydrviltteltlihrltnerrhvtHVQ
||.||..|||...|..|.|....|.....|||. .|.|.|. ||. |.                                                 ...
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.................................................qyl

YLGWPDHGVPDVDRFLALIDQVESLRaAHPRNMYTLVHCSAGIGRTGVVVQTMAMLailrrkRIPEAAAILRHLREQRARLVQTLQQYEFCF
.| |||||||| . .|  . ..   . |. ..  .|||||||.||||..|    ||      .  ..  .....||.|   |.. .|..|..
hlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 4413-4601 4.8e-17 56.8 In-house 6-196 (198) alignment
Range on Protein: 4413-4601
Range on HMM: 6-196/198.0
FICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLKTPSFVVEFVSQTSDDPYdrVILTTELTLIHRLTNERRHVTHVQYLG
.|..| |  .|. | ||..||     ||||   | .  .  . |||... |  |  |. |   . |.   |  .| .  ||         | ..| |.  
yiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdy..titaliltnnttappstreishyqfts

WPDHGVPDVDRFLALIDQV--ESLRAAHPRNMYTLVHCSAGIGRTGVVVQTMAMLAIL--RRKRIPEAAAILRHLREQRARLVQTLQQYEFCF
| ..  |.|  |. ..      | .    ..   .|||| | | ||| |     .      .  . .   . . ||. |  .. .||.|.| .
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 4413-4601 4.9e-17 56.7 In-house 7-197 (199) alignment
Range on Protein: 4413-4601
Range on HMM: 7-197/199.0
FICAQGPTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLKTPSFVVEFVSQTSDDPYdrVILTTELTLIHRLTNERRHVTHVQYLG
.|..| |  .|. | ||..||     ||||   | .  .  . |||... |  |  |. |   . |.   |  .| .  ||         | ..| |.  
yiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdy..titaliltnnttappstreishyqfts

WPDHGVPDVDRFLALIDQV--ESLRAAHPRNMYTLVHCSAGIGRTGVVVQTMAMLAIL--RRKRIPEAAAILRHLREQRARLVQTLQQYEFCF
| ..  |.|  |. ..      | .    ..   .|||| | | ||| |     .      .  . .   . . ||. |  .. .||.|.| .
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 4419-4603 2.4e-21 70.5 In-house 99-283 (302) alignment
Range on Protein: 4419-4603
Range on HMM: 99-283/302.0
PTSQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLKTPSFVVEFVSQTSD-----DPYDRVILTTELTLIHRLTNERRHVTHVQYLGW
|  .|.. || || . .| ..| .... ||.  |||.|.    .| ||   . |. ||   |     |  . .. | |..  .. .. .. |  ... .|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHGVPD-VDRFLALIDQVESLRAAhprnmyTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTA
|||| |.  .  | ..   || . .       |||||||.|||| .|     . .  .|.. . . |.  .|. |   ||. ||  . .  
pdhGapkeaytaldilkfcesykkn......vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllc

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 4421-4606 4.2e-17 57.1 In-house 38-219 (255) alignment
Range on Protein: 4421-4606
Range on HMM: 38-219/255.0
SQTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLKTPSFVVEFVSqtsddPYDR-VILTTELTLIHRLTNERRHVTHVQYLGWPDHGVP
| |||  .| |  ..  |.||.. ..|.|. ||  |.|   .. ||     |         .    |. | |.|.      . . |.| .| ||...  |
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.....ssadvvlrtleitstlgekkkthtvkhysykGWieknaP

DVDRFLALIdqvesLRAAHPRnMYTLVHCSAGIGRTGVVVQTMA----MLAILRRKRIPE--AAAILRHLREQRARLVQTLQQYEFCFTAVLA
.  | .  |     |....      .||||.||||.   | .      |.  |..    |     .|..||..|.| ..|  |  |..  || 
elareilni.....lkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld

subfamily_hpo-7_pd Subfamily hpo-7 4422-4606 1.7e-14 48.3 In-house 45-225 (263) alignment
Range on Protein: 4422-4606
Range on HMM: 45-225/263.0
QTVDDHWQLIWENDVRVIVMVAKLQEDGRSKCAPYWPSSDQGGLKTPSFVVEFVSQTSddpyDRVILTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDV
||.|  .| |  .   |.||..  .|.|. ||  |.|    . .|     |      |    | .. | ||. .     . . |.| .| ||...  |  
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs....dvllktlellstlgeKkkthtvkhysykgWiekndpel

-DRFLALIDQVESLraahpRNmyTLVHCSAGIGRTGVVVQTMA----MLAILRRKRIP--EAAAILRHLREQRARLVQTLQQYEFCFTAVLA
    | ... .  .     ..    ||||.||||.   . .      |.  |.       .   .|..||..|.| ..|  |  | .  || 
areilnilkvarns.....ks..lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd

0048076 (Phosphotyrosine protein) phosphatases II 4488-4604 2e-22 74.8 In-house 30-139 (145) alignment
Range on Protein: 4488-4604
Range on HMM: 30-139/145.0
LTTELTLIHRLTNERRHVTHVQYLGWPDHGVPDV-DRFLALIDQVESLRAAhprNMYTLVHCSAGIGRTGVVVQTMAMLAilrrKRiPEAAAILRHLREQ
.|| |.| . |... |......||.||||||||  . .|......|.....   .  .|||||||.||||..|  . ||     ..   .  .|...|.|
ittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsq

RARLVQTLQQYEFCFTAV
|   |.. .|..|.. ..
rpgavpnpgqlrflyefe

0038934 (Phosphotyrosine protein) phosphatases II 4491-4600 1.8e-10 36.2 In-house 56-169 (194) alignment
Range on Protein: 4491-4600
Range on HMM: 56-169/194.0
ELTLIHRLTNER---------RHVTHVQYLGWPDHG-VPDVDRFLALIDQVESLRAAHPRNmYTLVHCSAGIGRTGVVVqtmaMLAILRRKRIpEAAAIL
.|.|. .|||.          ..  ..  | .||.| ||. .  |  .| |.   ...| . . .||| ||.||||..|      ... | ..  | . .
klglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpgg.vvaVHCkaGlgRtGtlv....aaYLiyrlgm.saeeAi

RHLREQRARLVQTLQQYEFC
...|| |   ... ...|  
alfrekRpgaipnqdyleal

DSPc Dual specificity phosphatase, catalytic domain 4492-4598 2.4e-06 22.4 Pfam-A 19-131 (133) alignment
Range on Protein: 4492-4598
Range on HMM: 19-131/133.0
LTLIHRLTN-----ERRHVTHVQYLGWPDHGVPDVDRFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVVVqtMAMLAILRRKRIPEAAAILRHLRE-
.||.  .|.       .. .. .||. | .   . .    | . || ...|. ..   |||| ||| |.. ..  .| |   .. .. || ....  |. 
itlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatli..iaYlmktknlslneAyefvkerrsk

--QRARLVQTLQQYE
  ..|.....| .||
ispnagflrqLleye

DSPc Dual specificity phosphatase, catalytic domain 4492-4598 2.4e-06 22.4 In-house 19-131 (133) alignment
Range on Protein: 4492-4598
Range on HMM: 19-131/133.0
LTLIHRLTN-----ERRHVTHVQYLGWPDHGVPDVDRFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVVVqtMAMLAILRRKRIPEAAAILRHLRE-
.||.  .|.       .. .. .||. | .   . .    | . || ...|. ..   |||| ||| |.. ..  .| |   .. .. || ....  |. 
itlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatli..iaYlmktknlslneAyefvkerrsk

--QRARLVQTLQQYE
  ..|.....| .||
ispnagflrqLleye

0048179 (Phosphotyrosine protein) phosphatases II 4495-4601 2.8e-20 67.9 In-house 33-138 (144) alignment
Range on Protein: 4495-4601
Range on HMM: 33-138/144.0
IHRLTNE------RRHVTHVQYLGWPDHGVPDV-DRFLALIDQVESLRAahpRNMYTLVHCSAGIGRTGVVVQTMAMLailrRKRiPEAAAILRHLREQR
. .||.|       |.......|.||||||||  . .|.... .|....   ..  .|||||||.||||..|    |.    ...   .  .|...|..|
vinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrr

ARLVQTLQQYEFCF
   |.. .|..|. 
pgavpnpgqlrfLl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 4501-4612 3e-14 47.2 In-house 87-198 (440) alignment
Range on Protein: 4501-4612
Range on HMM: 87-198/440.0
ERRHVTHVQYLGWPDHGVPDVD-RFLALIDQVESLRaAHPRNMYTLVHCSAGIGRTGVVVQTMAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEF
| | . . .| ||||.||| .    | .|..|.  .  .  |   ||||||| |||||..   ..|   .|    .  ...  .|..| ..||| .|| |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesq.ekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

CFTAVLAKLKAAD
 . |||  | ..|
vheavlegllcgd

subfamily_PTPDC1_pd Subfamily PTPDC1 4504-4600 1.1e-09 33.0 In-house 82-168 (182) alignment
Range on Protein: 4504-4600
Range on HMM: 82-168/182.0
HVTHVqYLGWPDHGVPDVDRFLALIDQVESlraAHPRNmYTLVHCSAGIGRTGVVVQTMAMLAilrrKRIPEAAAIlRHLREQRARLVQTLQQYEFC
....   .||.|.||. ..| | ..  |..   |  ..  . ||| || |||||.. .. . |    ||.  . || . .|..|.. .|| .| |..
giyvy.nfgwkDygvasleriLdivkvvaf...alqeg.kvavhChaGlGrtGvliacylvya....krltaekai.klvrskrpksiqtreqvelv

PTPc_DSPc_SM00012 4505-4605 9.4e-25 82.2 In-house 2-104 (105) alignment
Range on Protein: 4505-4605
Range on HMM: 2-104/105.0
VTHVQYLGWPDHGVPD-VDRFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVVVQTMAMLAILRRK-RIPEAAAILRHLREQRARLVQTLQQYEFCFT
|.|..|.||||||||. .| .| |...|.. . .. ..  ..||||||.||||..|    .|  |... . ..   |...||.||...|||..|| |. .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVL
|.|
all

PTEN_1 4505-4598 6.1e-14 47.3 In-house 92-183 (196) alignment
Range on Protein: 4505-4598
Range on HMM: 92-183/196.0
VTHVQ--YLGWPDHGVPDVDRFLALIDQVESLRAAHPRNMYTLVHCSAGIGRTGVVVqtmamLAILRRKRIPEAAAILRHLREQR-ARLVQTLQQYE
  .|.   ....|||.|. ..... ...... . ..|..   |||| ||.||.|.||      | | .|.   |   |...||.| .. ... .| .
ksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv.....aayLmykgkltadeAlelvrekRppgapnspsqer

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 4505-4605 8.8e-09 29.5 In-house 217-341 (350) alignment
Range on Protein: 4505-4605
Range on HMM: 217-341/350.0
VTHVQYLGWPDHGV-PDVDRFL-------ALIDQVESLRAA-HPRNMYTLVHCSAGIGRTGVVVQTMAMLA---IL---R-R-KRIPEA-------AAIL
| ..|.  |.| ..  .   .|        |||.  .       |    |||||||.||||..|    .|    ||   . . ...  |         |.
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

RHLREQRARLVQTLQQYEFCFTAVL
 .||.|| ..||.|.|. |.. |.|
nelrkqrismvqnldqfifiYeall

subfamily_PTEN_pd Subfamily PTEN 4505-4591 1e-06 23.9 In-house 79-163 (184) alignment
Range on Protein: 4505-4591
Range on HMM: 79-163/184.0
VTHVQYLGWPDHGVPDVDRFLALIDQVESLRAAHPRNMyTLVHCSAGIGRTGVVVQTMaMLAILRRKRIPEAAAILRHLREQRARLV
 ..|. ..  ||  | .. . ......|.  .. ..|.   ||| || |||||.. .  .| .|  ..  || ..  . | . .. |
dgrvavypfdDhnppplelleeivediekwleedkknv.vvvHCkaGkGRtGvlivay.llkslllekaeealelfaeaRtknkkgv

subfamily_Tensin_pd Subfamily Tensin 4506-4562 8.5e-09 28.2 In-house 70-125 (189) alignment
Range on Protein: 4506-4562
Range on HMM: 70-125/189.0
THVQYLGWPDHGVPDVDRFLALIDQVESLRAAHPRNMyTLVHCSAGIGRTGVVVQTM
..|. .||||.  | .... ... ...|   |.|.|.   |||  | ||.||||.. 
kkvldfGWPdllaPsleklcsicksldsWlkadpqnv.vvvhckGgkgrigvvvsay

subfamily_CDKN3_pd Subfamily CDKN3 4510-4600 1.6e-07 25.1 In-house 104-188 (202) alignment
Range on Protein: 4510-4600
Range on HMM: 104-188/202.0
YLGWPDHGVPDVDRFLALIdqvESLRAAHPRNMYTLVHCSAGIGRTGVVVQTMaMLAILRRKRIPEAAAILRHLREQRArlVQTLQQYEFC
.   .| .|||.   | ..   | || .      |||||  |.||. .|.  . .| .       .| . ||.|.  ||  .||..||.. 
hypiadglvpdiasclkil...eelrinlkayrktlvhcygglgrsslviacl.llylddtiepkdaidklrdlkgsra..iqtvkqynyl

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 4527-4605 6.1e-06 19.8 In-house 250-341 (349) alignment
Range on Protein: 4527-4605
Range on HMM: 250-341/349.0
LIDQVESLRAAHPRNMY-TLVHCSAGIGRTGVVVQTMAMLAILRRK-----RI-------PEAAAILRHLREQRARLVQTLQQYEFCFTAVL
|||.  .    .  ..   ||||||| |||||.|    .|.||        .|            |. .|| ||  .|| |.|. ... |.|
liddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealL

subfamily_CG42327_pd Subfamily CG42327 4545-4603 5.9e-09 30.0 In-house 251-310 (319) alignment
Range on Protein: 4545-4603
Range on HMM: 251-310/319.0
LVHCSAGIGRTGVVVQT-MAMLAILRRKRIPEAAAILRHLREQRARLVQTLQQYEFCFTA
 |||| |.||||.|. . .|.  .   ||  .   .. ..|..||. |.| .|||| .  
vvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv