Gene MbrePTP-sf4-2 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily MbrePTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP051_AA protein Get Run
MbreP051_AA_2137-2434 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
TNFR_c6 TNFR/NGFR cysteine-rich region 365-408 1.8e-06 14.5 Pfam-A 1-39 (39) alignment
Range on Protein: 365-408
Range on HMM: 1-39/39.0
CAQGfTYESDgptPTTdRECSACLSCSTAEYQLQPCTLTTDRAC
| .| || ..    .. |.| .| .|.  ..  .||| | .. |
Ceeg.tYtds...knh.rqClsCskCepgtvlvspCtetqnTvC

TNFR_c6 TNFR/NGFR cysteine-rich region 429-458 1.3e-07 18.1 Pfam-A 9-39 (39) alignment
Range on Protein: 429-458
Range on HMM: 9-39/39.0
SSN-RLCAPCSECATDQFILQACNETTDTEC
|.| | | .||.|  ...  . |.|| .|.|
sknhrqClsCskCepgtvlvspCtetqnTvC

TNFR_c6 TNFR/NGFR cysteine-rich region 465-507 6.2e-06 12.8 Pfam-A 1-39 (39) alignment
Range on Protein: 465-507
Range on HMM: 1-39/39.0
CEPGEFREApctpT-AdMRCTACTTCAADQYQVATCTASTDRVC
||.|.. .     .   ..|..|..|  ... |. ||.  ..||
CeegtYtds....knh.rqClsCskCepgtvlvspCtetqnTvC

TNFR_c6 TNFR/NGFR cysteine-rich region 567-603 1.4e-08 21.2 Pfam-A 5-39 (39) alignment
Range on Protein: 567-603
Range on HMM: 5-39/39.0
QYQAPQQArdRVCRTCSTCEEGLYEVAACTTTTNRQC
.|.. ..   | |. ||.||.|...|. || | |..|
tYtdsknh..rqClsCskCepgtvlvspCtetqnTvC

subfamily_PTPN23_pd Subfamily PTPN23 2136-2435 9.3e-48 157.5 In-house 13-282 (288) alignment
Range on Protein: 2136-2435
Range on HMM: 13-282/288.0
DRARAREDWHALEAEKDlllDEARPENFSMAKRpgSLRSNRYRNILATNTNRVRLLgvPPERDYINADHI--VFPDEPhdlKYIMAQGPLQATVNDFWTM
...   . .. || ..|    |||    ..||.      ||.|.||  . ||| |     . ||||| ..  . |  |   ..|..|.||| |.|||| |
gktaldkkfkeleqkqd...kearkrsiaiakl..yseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcP...dfiatqaPlqstlnDFWlm

VAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCS
| .| . .| |... .| |. |.  |||.  || .. ||. |   |  . |    .. .|.    .. . |.| |. |||..|||.  |.|..|  .| |
vyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldeves

CCIAVPMMLGVvemftamvflqletfqaemprpaPLLVHCSAGVGRSGVVVLS-DVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKK
.  ||   . .                       ||.|||||||||.||. |   .... ...  ..|.  .|| .| ||   .|. ||.  .|.  |..
ayeavqrkskt.......................PlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

VLE
. .
arr

subfamily_PTPRN_pd Subfamily PTPRN 2136-2334 1.1e-27 91.5 In-house 27-219 (297) alignment
Range on Protein: 2136-2334
Range on HMM: 27-219/297.0
DRARAREDWHALEAEkdllldEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGV--PPERDYINADHIVfPDEPHDLKYIMAQGPLQATVNDFWTM
.. | ...|.|| |       || |.  ..||..  .. ||....|. . .||.|       . |||||  |.  ..|    || .|||| .|| ||| |
nkdrlekewealcay......eaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasail.dhdprapayiatqgplastvadfwqm

VAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGDVI--VEHLssYSDEFnTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQV
| .|||  | ..|.|.| |  .|. |||.   |   . .|    ||.  ..|..  |    |.    |..| |    |||||..|||.    |. |. .|
vweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehi..wcddy.lvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkv

CSC
  .
nks

0045450 (Phosphotyrosine protein) phosphatases II 2138-2431 2.9e-67 222.9 In-house 20-302 (307) alignment
Range on Protein: 2138-2431
Range on HMM: 20-302/307.0
ARAREDWHALEAEKDLLLDEAR--PENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVP---PERDYINADHIVF------PDEPHDLKYIMAQGPLQAT
 . ..... |..|   ||..    . ..|.|..| .   |||..||. . .||.|  ..   .. ||||| .. .      .   ...|.|..||||. |
lllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpet

VNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVvGERQTAGDVIVEHLSSYSdeFNTVHITELQLY---YRSQSRVVRHCQFLSWPDHGVPSDLED
|.||| |. .|||..| |.|.| | || ||..|||.  || .| |.. |. || .    . .... | .    . ..|| |.| ....|||||||...|.
vedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh..ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfee

LVRFQAQVCSCCIAvpmmlgvvemftamvflqletfqaeMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYI---PDVRTMVSIVRSQRPMTIQTLE
|..|  .| ... .                          |.. | ||||||||||.|.... ...    .|. .   .|..  |. .|.|||  .|..|
lldfieevrkalee.........................lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpe

QFTLLYDFALK
|.  ||...|.
qyrflyealle

subfamily_Ptp69D_pd Subfamily Ptp69D 2138-2427 1.9e-41 137.1 In-house 15-280 (307) alignment
Range on Protein: 2138-2427
Range on HMM: 15-280/307.0
ARAREDWHALEAEKDLLLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPP--ERDYINADHIVFPDEPHdlKYIMAQGPLQATVNDFWTMVA
.| |.  . |. | . |  .  . . .....   .  ||| .| | . .||.|  ..   . |||||..|   .| .  |.|.||.|..||..||| |.|
srkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekk..kfiaaqdPveatigDfWRmia

QQGVGTIAMVTQLQEGGRDKCYPYWPQVvgERQTAGDVIVEHLSSYSD------EFNTVHITELQLYyRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQA
.| | .| |...|.|  |.||  |||.   . .  ||..|.  |. .       |..  .. |       .|| |   ....|.|  ||   . |...  
eqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesge.vedsrkvvqyhytgWkDskvPevargllklie

QVCSCCIAVpmmlgvvemftamvflqletfqaemprPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYD
|| .                                 .|..|||||||||||..|  |.. .....    |.  .|  .||||.. .| |||.. || 
qvrelykln...........................rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyr

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2139-2435 6.9e-184 604.5 In-house 1-297 (297) alignment
Range on Protein: 2139-2435
Range on HMM: 1-297/297.0
RAREDWHALEAEKDLLLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPPERDYINADHIVFPDEPHDLKYIMAQGPLQATVNDFWTMVAQQG
|.|||...|||||||||||||.|.||.|||..|||.||||.||||...||.||.|..||||||||..|||||..|||||.|||||.|||.||||.||.|.
rlredrkeleaekdllldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqd

VGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAV
|..|.||..|||.|||||.||||.||.||..||||.||.|||.||||..|..|||||.|||.||||||.|||||||||||||||||||||||||||||||
vrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciav

PMMLGVVEMFTAMVFLQLETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVLE
||||..|||||||||||||...|||||.|.|||||||||||||||||||||..|.||..||||....||.|.||....||||||.||||..|||..|
pmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkklke

0051299 (Phosphotyrosine protein) phosphatases II 2141-2431 5.7e-69 228.1 In-house 19-284 (288) alignment
Range on Protein: 2141-2431
Range on HMM: 19-284/288.0
REDWHALEAEKDLLLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPP--ERDYINADHIVFPDEPHDlkYIMAQGPLQATVNDFWTMVAQQG
. ... |..| . ||.   . ..| |..|  |  |||..||. . .||.|  ...  . ||||| .| ... ..   .|..||||. ||.||| || .|.
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk..fIatqgPlpntvedFWrmvweqn

VGTIAMVTQLQEGGRDKCYPYWPQvvGERQTAGDVIVEHLSSYSDEFNTVHITELQLY----YRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSC
| .| |.|.|.| || ||..|||.  |. .| ||. |. || ....  ||.  |.. .    . ..|| |.| ....|||||||...|.|..|  .| ..
vrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrka

CIavpmmlgvvemftamvflqletfqaemPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALK
.                            ... | .|||||||||.|.... |.. .  .|.. .||  .|  .|.|||. .||.||. ..|. .| 
la...........................sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle

0040438 (Phosphotyrosine protein) phosphatases II 2142-2433 5.7e-69 228.1 In-house 15-276 (317) alignment
Range on Protein: 2142-2433
Range on HMM: 15-276/317.0
EDWHALEAEKDLLLDEARPeNFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPP--ERDYINADHIVFPDEPHDlkYIMAQGPLQATVNDFWTMVAQQGV
 |..||. |   ||.   . ..|.|..| .   |||..||    .||.|  ...  . |||||... .|....   .|..||||. ||.||| || .|||
sdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk..fIatqgPlpntvedFwrmvweqgv

GTIAMVTQLQEGGRDKCYPYWPQvvGERQTAGDVIVEHLSSYSdeFNTVHITELQLY--YRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCia
..| |.|.| | || ||..|||.  || .| ||..|..|| .    . .....|...  . |.|| |.| ....|||||||.....|..|  .| ...  
tvivmLteleelgrekcaqYwpl..getltygdftvtllseee..lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal..

vpmmlgvvemftamvflqletfqaEmPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKV
                        | ... |.||||||||||.|.... ... .  .|.. .||   |  .|.|||. .||.||.  |||..|. .
........................e.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

0043336 (Phosphotyrosine protein) phosphatases II 2142-2430 1.2e-65 217.1 In-house 17-274 (278) alignment
Range on Protein: 2142-2430
Range on HMM: 17-274/278.0
EDWHALEAEKDLLLDEARpENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPPE--RDYINADHIVFPDEPHDlkYIMAQGPLQATVNDFWTMVAQQGV
 ....|..|   ||.    ...|.|..| .   |||..||. . .||.|  .. .   ||||| .. ... |..  .|..||||. ||.||| || ..||
nlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk..fiatqgPlpetvedFwrmvwelgv

GTIAMVTQLQEGGRDKCYPYWPqvvGERQTAGDVIVEHLSSYSdeFNTVHITELQLY--YRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCia
 || |.|.| | || ||..|||   |. .| ||. |. |. ..  ....... | .   . ..|| |.| ..|.|||||||..|..|..|  .| ...  
ttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh..lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal..

vpmmlgvvemftamvflqletfqaEmPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
                        | ... |.||||||||||.|.... ... .  .|.. .|.   |. .|.|||. .||..|.  ||...|
........................e.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall

0050432 (Phosphotyrosine protein) phosphatases II 2143-2431 9.1e-73 240.6 In-house 40-297 (308) alignment
Range on Protein: 2143-2431
Range on HMM: 40-297/308.0
DWHALEAEKDLLLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLlgvPPERDYINADHIVFPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTI
|.. ||.|   ||.   ....| |..|     |||..||.   .||.|   ... ||||| .. ...  .. |.|..||||. ||.||| || .|.| .|
dlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvI

AMVTQLQEGGRDKCYPYWPQVVG-ERQTAGDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCscciavpmm
 |.|.|.| || ||..|||  .| . .. |.. |..|| ....  ||   ||. .  ..||.|.| ....|||||||...|.|..|  .|          
vmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvr.........

lgvvemftamvflqleT-FqaempRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALK
                . .     .. | .|||||||||.|.... |.. .  .|.. .||  .|  .|.|||. .||.||. .||. .|.
................ksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralle

0039614 (Phosphotyrosine protein) phosphatases II 2144-2433 1.9e-66 219.9 In-house 31-289 (297) alignment
Range on Protein: 2144-2433
Range on HMM: 31-289/297.0
WHALEAEKDLLLDEARPenFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPPE---RDYINADHIVFPDE-PHdlKYIMAQGPLQATVNDFWTMVAQQGV
 . |..|   ||.   .  .| |..| .   |||..||. . .||.| ...      ||||| .. ..|  ..  |.|..||||. ||.||| || .|||
ktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltr..kfIatqgPlpetvedFwrmvweqgv

GTIAMVTQLQEGGRdKCYPYWPQVVGerqTAGDVIVEHLSSYSdeFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAvp
 .| |.|.| | || ||..|||. .|   | ||. |. |. .    . .....| . . ..|| |.| |...|||||||..||.| .|  .| ... .  
tvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh..ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealae..

mmlgvvemftamvFlqletfqaemPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKV
                        |.. | ||||||||||.|.... . . .  .|.. .||   |. .|.|||. .||..|.  |||..|. .
.............l..........pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell

0036941 (Phosphotyrosine protein) phosphatases II 2145-2434 6.2e-71 234.4 In-house 13-278 (297) alignment
Range on Protein: 2145-2434
Range on HMM: 13-278/297.0
HALEAEKDLLLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLlgVPPERDYINADHIVFPDEPHDlkYIMAQGPLQATVNDFWTMVAQQGVGTIAM
. |. | . ||.   . ..| |..|. |  |||..||. . .||.|   ... ||||| .. ..| ..   .|..||||. ||.||| || .|.| .| |
alllkefeellpllllgslsvallpenleknRykdilpydhtRVkl..ddegsdYinAsyvdgydlkrk..fIatqgPlpntvedFWrmvweqnvtvIvm

VTQLQEGGRDKCYPYWPQVVGERQTAGDVIVEHLSSYSDEFNTVHITELQLYY--RSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAVpmml
.|.| | || ||..|||  .|| .| ||..|. || ............|....   ..||.|.|.....|||||||.. ..|..|  .| ... .     
ltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll....

gvvemftamvflqletfqaemPRPAPLLVHCSAGVGRSGVVVLSDVIANKTR---KGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVL
                     |.. | ||||||||||||.... |.. .  .   | . .|.  .|  .|.|||. .|||||.  ||.. |. ..
.....................psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk

0047943 (Phosphotyrosine protein) phosphatases II 2145-2430 4.1e-67 221.9 In-house 12-269 (273) alignment
Range on Protein: 2145-2430
Range on HMM: 12-269/273.0
HALEAEKDLLLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLlgVPPERDYINADHIVFPDEPHDlkYIMAQGPLQATVNDFWTMVAQQGVGTIAM
. |..| .|||.   . ..| |..|  .  |||..||. . .||.|   ... ||||| .. ... ..   .|..||||. ||.||| || .|.| .| |
tllleefelllslkplltysvallpenkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrk..fiatqgPlpntvedfwrmvweqnvrviVm

VTQLQEGGRDKCYPYWPQVVGE-RQTAGDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIavpmmlg
.|.|.| || ||..|||. .||  .| |...|..|| ....  ||.  ||. .  ..||.|.| ....|||||||..||.|..|  .| ...        
LtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale.......

vvemftamvflqletfqaEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
                  . |.. | .|||||||||.|.... |.. .  .|.. .||   |  .|||||. .||.||. .||...|
..................alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2145-2331 1.6e-32 107.9 In-house 22-207 (305) alignment
Range on Protein: 2145-2331
Range on HMM: 22-207/305.0
HALEAEKDLLLDEarPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPPE--RDYINADHIVFPDepHDLKYIMAQGPLQATVNDFWTMVAQQGVGTI
..|||. ..| .|  .| . . |.  . ..||...|   ...|..|   . .  .||||| ..   .  .  |||.|||||. ||.||| .. .  | ||
kgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgyk..rkkkyivaqgPlkntvadfWrliveekvsti

AMVTQLQEGGRDKCYPYWPQVVGERQTAGDVIVEHLSSysDEFNTVHITELQLYY---RSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQV
 |.|.|.|||.|||. |||. ..|..  |...||  |.   ...   . .|..      ..||.| . |. .|||||||     |...  .|
vmltklveggkdkCrqYWpesktekkefgefsvelkse..ktasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrv

subfamily_ptpA1_pd Subfamily ptpA1 2145-2322 3.4e-19 63.9 In-house 21-206 (418) alignment
Range on Protein: 2145-2322
Range on HMM: 21-206/418.0
HALEAEKDLLLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPP--ERDYINADHIvfpDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTI
| .. |  || .   | . |   .      ||| |||  |  ||.|  .      |||||..|   |  .  ..| .||||  |. ||| || .. .  |
hkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyi...dgaypkqfictqgplpntiadfwrmvwenrcrii

AMVTQLQEGGRDKCYPYWPQVVGERQTA---------GDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLE
 |...  |  | ||  |||. .|  | .         |   || .    |    .   ...| .  ..| . . |.  |||| .|   .
vmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtq

DSPc_SM00195 2148-2431 6.1e-62 204.7 In-house 3-260 (263) alignment
Range on Protein: 2148-2431
Range on HMM: 3-260/263.0
EAEKDLLLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVP--PERDYINADHIVFPdePHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMV
..| . |.... |.... |... . . |||.|||  . .||.|   .  .. ||||| .| ..   .. |||..||||. ||.|||.|| ...| .|.|.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TQLQEGGRDKCYPYWPQVVGERQTAGDVIVEHLSSYSDEfNTVHITELQLYYRS--QSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAVpmmlg
|. .| |. ||. |||.  |. .| |.. |.  .  ... . .....|.| .    ..| |.. |. .|||||||.. ......  .| ..         
teeeengkekcdrywpeesggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.....

vvemftamvflqletfqaemprPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALK
                       .|..|||||||||.|..|. |.| .| ...  .|.  .|. .|.|||. .|||||.. .|. .|.
......................sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

PTPc_SM00194 2148-2431 6.1e-62 204.7 In-house 3-260 (263) alignment
Range on Protein: 2148-2431
Range on HMM: 3-260/263.0
EAEKDLLLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVP--PERDYINADHIVFPdePHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMV
..| . |.... |.... |... . . |||.|||  . .||.|   .  .. ||||| .| ..   .. |||..||||. ||.|||.|| ...| .|.|.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TQLQEGGRDKCYPYWPQVVGERQTAGDVIVEHLSSYSDEfNTVHITELQLYYRS--QSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAVpmmlg
|. .| |. ||. |||.  |. .| |.. |.  .  ... . .....|.| .    ..| |.. |. .|||||||.. ......  .| ..         
teeeengkekcdrywpeesggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.....

vvemftamvflqletfqaemprPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALK
                       .|..|||||||||.|..|. |.| .| ...  .|.  .|. .|.|||. .|||||.. .|. .|.
......................sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

0045098 (Phosphotyrosine protein) phosphatases II 2153-2433 1.3e-61 203.8 In-house 15-272 (278) alignment
Range on Protein: 2153-2433
Range on HMM: 15-272/278.0
LLLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRllgvpperDYINADHIVFPdephDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGG
 ||    |  .. | ..|.|  |||..||. . .||.        ||||| .| ..    . |.|..||||. ||.||| |. ..|. .| |.|.|.|.|
fllllgipseitpalylgnldknRykdilpydhsrVk........dYINAsyidgy....pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelg

RDKCYPYWPQvvGERQTAGDVIVEHLSSYSDEFNTVHITELQLY----YRSQSRVVRHCQFLSWPDHGVPSDL--EDLVRFQAQVCSCCIAVPMMLGV-V
| ||..|||   |. .| ||. |. || .  .  |..  ...      .  .|| |.| ..|.||||||||.     . ..  ...... ..  .|.. .
rekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssl

emftamvflqletfqAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTrkGYIPDVRTMVSIVRSQRPM-TIQTLEQFTLLYDFALKKV
                 .... | ||||||||||.|..|. . .      .   |.   |. .|||||.  .|.|||.  ||.|.|. .
...............llldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2154-2427 9.9e-33 108.6 In-house 31-282 (325) alignment
Range on Protein: 2154-2427
Range on HMM: 31-282/325.0
LLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRL--LGVPPERDYINADHIVfpDEPHDLKYIMAQGPLQATVNDFWTMVAQQGvGTIAMVTQLQEG
||    .  . .| .|     ||..|..| . .|| |  ..  |. |||||...   |.     .. || || ||.||.| .| .    .. .|.   ..
llpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylr..ddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldl

GRDKCYPYWPQVVGERQTAGDVIVEHLS--SYSDEFntVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCScciavpmmlgVVemft
| |.|  |||. .|. .| | . |.  .   .||      . ...   . ..| |.  |. ||.| ||.     |. .   |            |     
gkdrcavywpkemgksktfGglevklrtieeisdyv..hrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvka..........vs....

amvflqlETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYD
       |. .|.    .|.||||||||||.|| .    ...|  .    |.  .|  .| .||  ..| .|..|.|.
.......ervtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliye

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2154-2331 5.9e-30 99.4 In-house 31-207 (319) alignment
Range on Protein: 2154-2331
Range on HMM: 31-207/319.0
LLDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVP--PERDYINADHIVFPDepHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEG
||.|| ...|. |...   . |||.|||| .  || |  ..  .. |||||..|   .  .  |.| .|.||. |..||| || .... .. |.|.|.| 
llkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyq..erekfiatqaPlentiedfWrmvWeeessivvmltklvek

GRDKCYPYWPQVvgERQTAGDVIVEHLSsySDEFNTVHITELQLYYRSQ---SRVVRHCQFLSWPDHGVPSDLEDLVRFQAQV
.. |.  |||.   . .. | .||. ..   .| . . | .|.|  .|.   .| | | |...||||.|| ..  |. .  ..
lkvklkkywpee..nfeeyGrlivtlee..eeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkri

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2155-2319 1.5e-26 88.2 In-house 35-194 (297) alignment
Range on Protein: 2155-2319
Range on HMM: 35-194/297.0
LDEARPENFSMAKRPGSLRSNRYRNILATNTNRVRLL--GVPPERDYINADHIVFPDEphdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGG
| ||   .  .|..   .  .||.||| ....||.|   .  |. ||.|| ..    .    ..|  | | .|||.|||.|| .. | ||.|.....|. 
lpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh....rlittqmPmkatvadfWamvldeqvstivmlnddnerd

RdKCYPYWPQVVgeRQTAGDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPS
. ||  ||..     .| ||| |. ||  . |       |..     . |||.  ||..|||. |. 
k.kcaryWsdkg..vttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaver

subfamily_PTPRK_pd Subfamily PTPRK 2157-2434 7.2e-41 135.0 In-house 29-278 (314) alignment
Range on Protein: 2157-2434
Range on HMM: 29-278/314.0
EARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPPE--RDYINADHIvfpDE-PHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGR
|. .| .  ||.    . ||. .||| .  ||.|  .  .   |||||. |   |   .  ..|..||||| ||.||| .| ...  .| |.|.|.| ||
eslfegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaali...dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgr

DKCYPYWPQvvgERQTAGDVIVEHLSSYSDEFNTVHITELQLYYRS--QSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAvpmmlgvvemftam
 ||. |||.   . .. ||. || ...  ..   | |  ..   |.  . |.||. |||.||||.||   . |... ..| .                  
vkClkyWPe...dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..............

vflqletfqaempRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVL
             .  ...|||||| ||.|. .  |.. .  ..  . ||  .|  .||...  ..| ||....|| .|  .|
.............eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileacl

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2157-2427 1.1e-31 104.7 In-house 24-271 (287) alignment
Range on Protein: 2157-2427
Range on HMM: 24-271/287.0
EARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPPE-RDYINADHIvfPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDK
|. .  |  |.   . . ||| ..|  . .|| |   .    |||||...  .   .| ..| ||||. |||.|||..| .. . .....|.  | .| |
esstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyv..asytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlk

CYPYWPQVVGERQTAGDVIVE-HLSSYSDEFNTVHITELQLyYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCScciavpmmlgVVEMftamvfl
|| |||.     .  |  .|    .  . |. .  .  ..|    ..|||.  ..|||||....     |.||  .|             .|.       
cykywPerevPmrvGGysvvlldydikePeygvralrlidl.etrearvvkqldllswPdkvlaPtavglirfvldvkq..........hiel.......

qletfQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYD
     . .     ||.||...|.||||...   |. ..  .    || ..|  .| .|   .|.  |. |||.
.....ardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllye

subfamily_PTPN1_pd Subfamily PTPN1 2157-2333 4.7e-29 96.0 In-house 18-193 (290) alignment
Range on Protein: 2157-2333
Range on HMM: 18-193/290.0
EARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGvpPERDYINADHIVFPDepHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKC
||.  . . ||.|     ||||..   .  |..|     . |||||. . ...   . .||..||||  ||. || || .|   .. |. .. | .. ||
easdfptreaklpenrnlnryrdvspydhsrikler..adndyinaslvelee..akrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikc

YPYWPQVVGERQTA---GDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCS
. ||||   |..       . |. .|  . .. ||.. ||.     ..|.. |  ...||| |||.    ...|  .| .
aqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvre

subfamily_PTPRD_pd Subfamily PTPRD 2158-2433 8.4e-60 198.0 In-house 35-281 (564) alignment
Range on Protein: 2158-2433
Range on HMM: 35-281/564.0
ARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVP--PERDYINADHIVFPDepHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDK
 . .... |. |   . ||| ||.| ...||.|  |.  .. ||||| .|   .  .. .|| .||||. |..||| || .| . || |.|.|.| |..|
gqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr..krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvk

CYPYWPQVvGeRQTAGDVIVEHLSSYsdEFNTVHITELQL--YYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCiAvpmmlgvvemftamvf
|  |||.  | ..| |...|.  ...  |.....|....|    .|.|| ||. .| ||||||||   ..|...  .| ..                   
chkYWPek.g.tetygeltVtleeee..eladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e................

lqletfqaemPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKV
          |   |..|||||||||.|. .  |.. .. ..    |....|. .|.||.. .|| ||.  ...  |. .
..........pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileal

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2158-2331 6e-36 119.0 In-house 34-204 (288) alignment
Range on Protein: 2158-2331
Range on HMM: 34-204/288.0
ARPENFSMAKRPGSLRSNRYRNILATNTNRVRLLG--VPPERDYINADHIvfPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDK
 . .. ......   . |||||||. . .||.| .    .. ||||| .|   .| .. ||| .||||..|||||| .| .. . ||.|.|.| |||. |
ektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyi..dgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktk

CYPYWPQVvGERQTAGDVIVEHLSSYSDEfNTVhITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQV
|  |||.  .. .  |.| |. ..|   | ..|   .| |  . . . . . |.|.||||||| . ..|. .  ||
CeeYWPda.dkpknyGsvtvtlveskele.dfv.lrklllekkkteleitqyqylaWpdhgvPeskapllellrqv

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2159-2331 3.6e-35 116.7 In-house 44-214 (298) alignment
Range on Protein: 2159-2331
Range on HMM: 44-214/298.0
RPENFSMAKRPGSLRSNRYRNILATNTNRVRLLG--VPPERDYINADHIVFPDEPHdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKC
. |. ..|..|   . ||| .|.| .  ||.|       | ||||| ..   .. .   .|..|.||..||.||| || .. .||| |.|.|.| .. |.
eeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn..afiatqaPltetvedFWrmvteedigtiVmltnleeldktky

YPYWPQVVgeRQTAGDVIVEHLSSysDEFNTVHITELQL--YYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQV
  |||..    .| |.. |. ||.  .||  . ...|..  . ....| ||. .| ||||.|||.  . .. . ..|
hkywPdeg..ketygeitvsllsk..eefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkv

subfamily_PTPN9_pd Subfamily PTPN9 2160-2428 7.8e-50 164.6 In-house 31-285 (297) alignment
Range on Protein: 2160-2428
Range on HMM: 31-285/297.0
PENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPP--ERDYINADHIVFPDEphDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCY
  .| ..| .. |. ||| ..|  .  || |  |.   . |||||...    .     .| .||||. ||.||| || .| | .| |.|.. | || || 
eGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykq..kkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcg

PYWPQVVGERQTAGDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAVpmmlgvVEMFTamvflqle
 |||.  ....  ||. |....  . |  .|.. |..    ..|| | | |||||||.||||. ..|. .  .| .   ..      |. ..        
qyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqala......vkelg........

TFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDF
  ..  |.  |..||||||.||.|  .  |.  .. ..    ||.  |. .|.||  .||| ||... |  
dewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcyla

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2160-2427 4.4e-47 155.4 In-house 15-262 (274) alignment
Range on Protein: 2160-2427
Range on HMM: 15-262/274.0
PENFSMAKR--PGSLRSNRYRNILATNTNRVRLLGVPPE---RDYINADHIVFPDEPHDlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRD
| ||....   .|| . |||..||  .. || |    .|    .||||..|  .|| .   |. .||||. ||.||| |. |. |  | |.|.|.|  ..
PlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeesk.ayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneq

KCYPYWPQVVGE--RQTAGDVIVEHLSsySDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVcscciavpmmlgvvemftamv
||  |.|.  .    .. ||| ..  .    | |  ....| | | ...| | |  . .|||| .| | . |... ..|                     
kCavyfPdaedyeiserygdveikvek..iverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvlev.....................

flqLETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYD
    |. ..|  . || .||||||.|| |. .  ..  .. |.  . ||  .|. .| .|   .|| ||. |.. 
...eesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihr

subfamily_PTPRB_pd Subfamily PTPRB 2160-2332 7.3e-41 135.1 In-house 40-209 (293) alignment
Range on Protein: 2160-2332
Range on HMM: 40-209/293.0
PENFSMAKRPGSLRSNRYRNILATNTNRVRL--LGVPPERDYINADHIvfPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCY
 .. ..|...     |||.|||. ...||.|  |   .. |||||..|  |.     ..| .||||  ||.||| || .. . .| |.||| |.|. || 
dqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyi..pgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCe

PYWPQVVgERQTAGDVIVEHLSSysDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVC
 |||.   | .. ||. |. ...  .| .   | ||..  ....| ||...|.||||||||.. . |..|  .| 
eYWPade.epvlyGdikvtlvae..eeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvr

0046845 (Phosphotyrosine protein) phosphatases II 2161-2433 3.5e-67 222.1 In-house 18-274 (284) alignment
Range on Protein: 2161-2433
Range on HMM: 18-274/284.0
ENFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPPE---RDYINADHIVFPDE---PHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRD
 ..| |..|  |  |||..||. . .||.|  ....    ||||| .. ..|     .  |.|..||||. ||.||| || .|.| .| |.|.| | || 
lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengre

KCYPYWPQVvGERQTAGDVIVEHLSSYSDEFNTVHITELQLYY-RSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAvpmmlgvvemftamvf
||..|||.  || .| ||..|. || . ..  ||.  ||. .   ..|| |.| ...||||||||...|||..|  .| ... .                
kcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen................

lqletfqaeMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGY---IPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKV
         .|.. | .|||||||||.|.... |.. .  .|.     .||  .|. .|.|||. .|||||. ..|...|  .
.........lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl

subfamily_PTPRA_pd Subfamily PTPRA 2161-2430 7.2e-41 135.1 In-house 48-292 (330) alignment
Range on Protein: 2161-2430
Range on HMM: 48-292/330.0
ENFSMAKRPGSLRSNRYRNILATNTNRVRLLGV--PPERDYINADHIVFPDEphDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYP
  . .|..    . ||. |||  . .|| |  .   .| ||||| .|    |    |.| ||||.. ||.||| |. .|   || |.|.|.|  ..||. 
atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGyke..kdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaq

YWPQVvGeRQTAGDVIVEHLSSYSDEF---NTVHITEL-QLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCciavpmmlgvvemftamvfl
|||.  |   | |.. ||   .   .      . ...| .   . .||.||   | |||| |||..   .... ..| ..                    
ywPde.G.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkkl....................

qletfQAEMPRpaPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
     .  .    |. |||||||||.|  .  | . .. .   . ||  .|. .| |||  .||.||....|   |
.....nqqsag..pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvll

0040439 (Phosphotyrosine protein) phosphatases II 2162-2431 2.2e-61 203.0 In-house 2-244 (249) alignment
Range on Protein: 2162-2431
Range on HMM: 2-244/249.0
NFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPP--ERDYINADHIVFPDEPHDlkYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPY
..|.|..| ..  |||..||. . .||.|  .|     ||||| .| ... ...  .|..||||. ||.||| |. ..|...| |.|.|.| || ||..|
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr..fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WPQvvGERQTAGDVIVEHLSSYSdeFNTVHITELQLY--YRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCscciavpmmlgvvemftamvflqle
||.  |. .. ||. |. || ..  .. .....|.|.  | ..|| |.| |...|||||||...|||..|  .|                          
wpl..ggsleygdftvtllsvev..kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavr.........................

TFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALK
....| |.. |.||||||||||.|.... . . .  .| .  |.   |. .|||||. .|..||.  ||...|.
kaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle

subfamily_PTPN3_pd Subfamily PTPN3 2162-2431 4.1e-55 181.7 In-house 32-273 (280) alignment
Range on Protein: 2162-2431
Range on HMM: 32-273/280.0
NFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPPerDYINADHIVFPDEP--HDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPY
. |.|..|  |  ||||.||. .. ||.|   .   |||||... .  .      .|| .||||. |..|||.|| .| . .| |.|.| | || ||. |
aisaarkpenlsknryrdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WPQvVGERQTAGDVIVEHLSSysDEFNTVHITELQLYYRS--QSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCiavpmmlgvvemftamvflqle
||.  ..... |.  |.  ..  || ... . || |  ..  ..| . . |.|.|||||||.| .|...|  .| ..                       
WPe.tedeleygefsvkceke..detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr......................

tfqaeMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALK
       .  |..||||||.||.||..| ..   .. .     .  .|. .| || | .|| .|.... .  ||
.....sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk

subfamily_PTPN14_pd Subfamily PTPN14 2162-2430 2.3e-52 172.9 In-house 40-293 (300) alignment
Range on Protein: 2162-2430
Range on HMM: 40-293/300.0
NFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPP-ERDYINADHIVFPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYW
..| || |   . ||....|  . |||.|      . .|||| .|  .   ....||.|||||. ||.||| || .|||  |.|.|. .|.|..|.. |.
llstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyf

PQVVGERQTAGDVIVEHLSSYSDEFNTVHITELQLYY--RSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAVPMMLgvvemftamvflqlET
|.   ...|.     .  . .|.. ..|  | |.|..   .. | | | |.  |||||||.|... . .  .| | . ..  .               |.
PkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsev..............es

fQAEMPrpaPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
 . . |   |.||||||||||.||..|||.. .   ..   |........| || . .||| |.. .|.  .
.keskP...PvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli

subfamily_PTPRG_pd Subfamily PTPRG 2162-2434 3.7e-41 136.0 In-house 38-288 (563) alignment
Range on Protein: 2162-2434
Range on HMM: 38-288/563.0
NFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPP---ERDYINADHIVFPDEPHdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYP
. .....| . | ||| ||.| .  ||.| ..|    . |||||..|      .  ..|..||||. |..||| |. .| | .| |.|.|.| || ||  
daehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqksk..afiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdv

YWPQvvGERQTAGDVIVEH-----LSSYSDEfnTVHITELQLYYRSQ---SRVVRHCQFLSWPDHGVPSD-LEDLVRFQAQvcscciavpmmlgvvemft
|||.   | .| | . |       |..|. .  |. | .|.|   .|    ..||. .. .|||||||.  | .|   . .                   
YWPk..desetygalqvtlieeevlalytvr..tlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks...................

amvflqletFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVL
          .|..    |..|||||||||.|. .  | . .. ..  . .|  ..  .|.||.. .|| ||.. |.|  |. ..
.........saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia

subfamily_PTPN13_pd Subfamily PTPN13 2162-2334 9e-38 125.1 In-house 28-198 (273) alignment
Range on Protein: 2162-2334
Range on HMM: 28-198/273.0
NFSMAKRPGSLRSNRYRNILATNTNRVRLLGVPPerdYINADHIVFPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWP
. ...|.    . |||||.|  .  ||.| .  .   ||||..|  | . .  .||..||||  ||.||| || .| .  |||||. .|.|. ||  |||
tcevgkkkenkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP

QVVGERQTAGD-VIVEHLSSY-SDEFNTVHITeLQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSC
.  ... .. . . || |     |.|.  ... ..    ..|| | | .| .||||||||  ..|..| |.| . 
esknkklkvsnrlevellkvqkldgfvvrala.vkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrl

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2162-2331 4e-34 112.9 In-house 35-202 (315) alignment
Range on Protein: 2162-2331
Range on HMM: 35-202/315.0
NFSMAKRPGSLRSNRYRNILATNTNRVRL--LGVPPERDYINADHIvfPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPY
.   |. .   . |||.|||  ...||.|  .   |..||||| .|  .   .|  || .||||.|.|.||| || |. | ||.|||..||| . ||  |
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyi..ksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqy

WPQVVGERQTAGDVIVEHLSSYSDEFNTvhITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQV
||.  ..    | . || ||  .|   .  . .| .    .|| |   ||  |||.||. ..  |...  .|
wPdrkadsvefGsikvellsleadtdgv..arklvtrkseesrtvtqfqftewPdkGvdkqtssllklikev

0037934 (Phosphotyrosine protein) phosphatases II 2163-2430 1.1e-56 187.5 In-house 2-239 (243) alignment
Range on Protein: 2163-2430
Range on HMM: 2-239/243.0
FSMAKRPGSLRSNRYRNILATNTNRVRLlgvpPERDYINADHIVFPDephdlKYIMAQGPLQATVND----FWTMVAQQGVGTIAMVTQLQEGGRDKCYP
||.|..| .|  |||..||. . .||.|    .  |||||..|  ..     ..|  ||||. ||.|    || |. ..|...| |.|.|.| || ||..
fsiallpenlsknrysdilpydhsrvkl....egsdyinanliyvtp.....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPqvvGERqTAGDVIVEHLSSYSdeFNTVHITELQLYY---RSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAVPMMLgvvemftamvflq
|||   ||  | ||..|. ||...  .. .....|.|..     ..| |.| ..|.|||||||.. |||..|  .|.... ..  .|             
ywp...gev.tygdftvtllseeh..lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsll.............

letfqaEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTrkGyiPDVRTMVSIVRSQRPM-TIQTLEQFTLLYDFAL
        ..  |.||||||||||.|.... ...  .   |   |.   |  .|.|||.  .||..|.  ||...|
......aldsggpvlVHCsaGvgRtGtliaaylmllll..g..vdleeavkllreqRpgkavqtpsqyrflyeall

0042113 (Phosphotyrosine protein) phosphatases II 2164-2430 1.3e-59 196.9 In-house 2-240 (245) alignment
Range on Protein: 2164-2430
Range on HMM: 2-240/245.0
SMAKRPGSLRSNRYRNILATNTNRVRLLGVPPE--RDYINADHIVFPDEPHDlkYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWP
| |..| .   |||..||. . .||.|  ....   ||||| .. ... ..   .|..||||. ||.||| |. ..|. || |.|.. | || ||..|||
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk..fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywp

QvvGERQTAGDVIVEHLSSYSdeFNTVHITELQLY--YRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFqaqvcscciavpmmlgvvemftamvF------
.  || .| ||..|. || ..  ........|..   . ..|| |.| ..|.|||||||..||.|..|                         .      
l..gesltygdftvtllseeh..lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldf.........................lefvrka

--LqletfqaemPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
            ... |.||||||||||.|.... . ...  .| .  ..   |  .|||||. .||..|.  ||...|
lae.........dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2164-2428 9.9e-49 160.7 In-house 13-259 (270) alignment
Range on Protein: 2164-2428
Range on HMM: 13-259/270.0
SMAKRPGSLRSNRYRNILATNTNRVRL--LGVPPERDYINADHIVFPDEPHDlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWP
.. .     . |||..|| . . ||||  |   ..  |||| ..   |. .  ||| |.|||..|...|| |. .. | .|.|.|.|.| ||.||  |||
dlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekk.kYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWp

QVVGERQTAGDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQaqvcscciavpmmlGVVEMFTAMvflqlETFQA
. ..|. .  |  .. |.. .   .   .|.|.| .....| . | .. .|||||||.. .. .. .               ...|. |.       .. 
aepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstd..............qllkmlrav.....rrsek

EMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDF
|. .  ||||||||||||.|.... | . .   .    || .... .| .|.  .|. ||...||  
eldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflyka

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2164-2334 8.6e-37 121.8 In-house 33-202 (281) alignment
Range on Protein: 2164-2334
Range on HMM: 33-202/281.0
SM-AKRPGSLRSNRYRNILATNTNRVRL--LGVPPERDYINADHIvfPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYW
.  .|..     |||.|| | .  ||..       . |||||...  |    . .|| .|||. |....|| || .| | .|.|||.  |.|. ||. ||
ataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfv..pgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYW

PQVVgERQTAGDVIVEHLSSYSDEFNTVHITELqLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSC
|.   .. . |||.|..... . .    .  .|     ...| |.. ....|||||||.. ..|. |...| ..
Pddn.selkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkl

subfamily_PTPN12_pd Subfamily PTPN12 2164-2328 4.4e-33 109.4 In-house 33-196 (290) alignment
Range on Protein: 2164-2328
Range on HMM: 33-196/290.0
SMAKRPGSLRSNRYRNILATNTNRVRLLGVPPER--DYINADHIVFPDEphDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWP
......   . |||..||  ...|| |     |   |||||..|  ...  .|.|| ||||| .|..||| |. .. |  . |. .. | |. ||  |||
eagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgveg..kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

QVVGERQTAGDVIVEHLSSYSDEfNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQ
. ..|. . |.. |.  .    . .   |  |..  ...||.|.  .. .||||||||  ..|... 
eegeeelefgefevtleeekavd.ddflirtLkveaqkesrkvyqfhYtaWPDhgvPssakslleli

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2164-2431 9.5e-33 108.4 In-house 42-277 (315) alignment
Range on Protein: 2164-2431
Range on HMM: 42-277/315.0
SMAKRPGSLRSNRYRNILATNTNRVRL--LGVPPERDYINADHIVFPDEPHdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWP
 .||.    . ||| ||.|..  ||.|  | . |. ||.||. |   . ..  .|| ||||. |.|.||| .| .. .|.| |.|.| || . |.  |||
dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkr..ryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp

QVvgeRQTAGDVIVEHLSSYSDEFNTvhITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVcscciavpmmlgvVEMFTAMVflqletfqa
     . . | . | . |    .  |  .  |   .... | |   .. |||| |||     |. .  .|                 |. |         
dk...kviyGkitvtrkseevnteyt..vrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtv.............kqhhtnsv.........

emprpAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALK
     ....|||||||||.|  .  | . ..     . ||  ..  ||..|   .|..||. ..||  |.
.....gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2164-2331 1.2e-32 108.1 In-house 2-166 (250) alignment
Range on Protein: 2164-2331
Range on HMM: 2-166/250.0
SMAKRPGSLRSNRYRNILATNTNRVRLLGVP--PERDYINADHIVFPDEPhdLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDkCYPYWP
|.||.|  .  ||| .|.| .  || |  .    | ||||| ..   ||     .|..|||||||..||| || .. .||| |.|.|.| ..  .  |||
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder..kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP

qvVGERQTAGDVIVEHLSSysDEFNTVHITELQLY--YRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQV
  | . .. ||| |. ||.  .||  . ...|.|    ....|.||. .|..||| |||   .  . .. .|
..vekaekyGdvtvsllsk..eefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkv

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2164-2331 4.2e-24 79.7 In-house 38-161 (392) alignment
Range on Protein: 2164-2331
Range on HMM: 38-161/392.0
SMAKRPGSLRSNRYRNILATNTNRVRL--LGVPPERDYINADHIVFPDepHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGrdkcypywp
..|...  |. |||.|||  ...||.|  .   |..||.|| .|   |   .  || .|||  |...||| || |. | ||||||.|.||          
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfd..nekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........

qvvgerqtagdvivehlssysdefntvhitelqlyYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQV
                                      . | |   .|  |||..||     |..|  .|
...................................kgddartvaqfhftewPdkdvpkhtssllkfikev

subfamily_eak_pd Subfamily eak 2164-2434 1e-15 52.0 In-house 45-306 (332) alignment
Range on Protein: 2164-2434
Range on HMM: 45-306/332.0
SMAKRPGSLRSNrYRNILATNTNRVRLLGVPPERD-YINADHIVFPDEPHdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQ
| ..|  ... |   .|.  . . |||     .|. ||||  . |..  .  |||..  . .  |  || || .|   .| .. .  | . .|   |.|.
setarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGr..kyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpd

VVGERQTAGDVIVEHlSSYsDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSdLEDLVRFQAQVCSccIAVPMMlgvVEMFTAMVFLQLETFQAE
   |    | . ||   ..  . | ..   |.|    ..  | | ..  | .  .|  .||.. ..  .    . |...   . | .|..   |  ..  
ktreelkfGildver.kef.vkrniletrllelskGnethrvlhykvfGwtettlpk.yedflalrkvmke..vGvlll...ivmksallsstlkkyiht

MPRPAPLlVHCSAGVGRSGVVVLSDVIAN--KTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVL
 |  ||. . .. |  |.|| |. |.. .    .|     |  ..  |.|.|  .. .  | ...|.  |. .|
ppsfapi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll

subfamily_PTPN6_pd Subfamily PTPN6 2165-2428 5.8e-50 165.0 In-house 48-292 (306) alignment
Range on Protein: 2165-2428
Range on HMM: 48-292/306.0
MAKRPGSLRSNRYRNILATNTNRVRLL-GVPPERDYINADHIVFPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQV
 ...|   . |||.|||  . .|| |     |. |||||. |    . .| .|| .|| |..||.||| || |.    | |.|.  | |..||..|||..
egakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPde

VGERQtAGDVIVEHLSSysDEFNTVHITELQL---YYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAVPmmlgvvemftamvflqletfQ
  ...  |.. |...|.  .. ..  . ||..      ...| |.. .| ||||||||.| . .. |  .| .    .                     .
eekee.yGkisvtnvse..ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeele....................e

AempRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKG---YIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDF
|   .. |..||||||.|| | ... |.. .. .|    .  |....| .||.||   .|| .|. ..|  
a...eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvyka

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2165-2318 1.2e-22 75.1 In-house 40-195 (290) alignment
Range on Protein: 2165-2318
Range on HMM: 40-195/290.0
MAKRPGSLRSNRYRNILATNTNRVRLLGVPPERD----YINADHIVfpDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYW
..  . . . ||..||. .. ||. |  .. ..|    |||| .|   .  .. .||..|||.. |. ||| .. |. |  | |.|. .| |..||. ||
vgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyik..gykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYW

PQVVGERqtAGDVIVEHLSSYSDEFNTVHITELQLYYR-SQSRVVRHCQFLSWPDHG-VP
|.   ..   | . .. |.  . .  .    |..      ... | . |. .|...| |.
pdsdtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvt

0049772 (Phosphotyrosine protein) phosphatases II 2166-2432 1.4e-27 92.7 In-house 41-279 (314) alignment
Range on Protein: 2166-2432
Range on HMM: 41-279/314.0
AKRPGSLRSNRYRNILATNtNRVRLlGVPPE--RDYINADHIVFPdephdLKYIMAQGPLQATVNDF----------WTMV--AQQGVGTIAM-------
|. .     ||| .||  . |||.| .  |    |||||...  .     ||.| .||||. ||.||          |.||   .. | .| |       
adlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------VTQLQEGGrdkcypywpqvvgerqtagdvivehlssysDEFNTVHITELQlyyrsqS----------RVVRHCQFlSWPDHGVPsD
               ..| ..|                              .| .  .. .|.      .          ........  .||...| .
delsrLdaAlgKtpllildgng..............................neptaadlellk......eelydpelferlgikylri.pvpDgsap.l

LEDLVRFQAQVCSCciAvpmmlgvvemftamvflqletfqaempRPAPLLVHCSAGVGRSGV-VVLSDVIANKtrkGYipDVRTMVSIVRSQRP-----M
|||. .| . . ..                              .. |.||||.||.||.|. ||.  ..      |.  .... .. ||..||      
ledfdeflefieea..d...........................kggpvlvHCkaGkgRtgtfvvaaylmkll...gv..sleealedvrlkRpinpnpg

TIQTLEQFTLLYDFALKK
.|..|||.   ... |..
fieqleqyefilealley

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2167-2331 4.8e-33 109.5 In-house 42-204 (318) alignment
Range on Protein: 2167-2331
Range on HMM: 42-204/318.0
KRPGSLRSNRYRNILATNTNRVRLLGV--PPERDYINADHIvfPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVv
  |   . ||| |||| .. ||.|  .   .. |||||..|  .   .. .|| ||.||  |..||| || .|.  .| |.||..| |..|.  |||.  
lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyi..dGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk.

gERQTAGDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQV
 . .. |.. ||  .. . .  ..   ...    ..||.||  .. ||||.|||..  .|. .  ||
.gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqv

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2167-2318 6.1e-20 66.1 In-house 36-204 (301) alignment
Range on Protein: 2167-2318
Range on HMM: 36-204/301.0
KRPGSLRSNRYRNILATNTNRVRLLGVPP----ERDYINADHIVfpDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQ
 .    . ||..||   . ||. |   |     .|.|||| .|   .  .  |.|.||||.. |. ||| .. |. . .| |||.|.|| ..||. |||.
lseenkalnrfknitvyddnriilkpkpnldlcqreyinasyid..gysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpn

VVGERQTAGDVIVEHLSSY--------------SDEFN-TVHITELQLYYRSQSRVVRHCQFLSWPDHGVP
   |... | . |.  ...               | .| .  . ...   . .|. |   |  .||..|| 
seaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvv

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2167-2328 6.1e-19 62.7 In-house 33-193 (281) alignment
Range on Protein: 2167-2328
Range on HMM: 33-193/281.0
KRPGSLRSNRYRNILATNTNRVRLLG-VPP--ERDYINADHIVFPDepHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQV
..|   . ||| || . .  ||.|   .|     ||| |..|  |       ||..||| . |  ||| |. |.   .| |. |. |  |.||  |.|. 
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf..lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn

VGERQTAGDVIVEHLSSYSDefNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQ
         . |..  |  .  ...  | |.| |  ..|.. |  .  |||  ||   | ...  
ahcclqfdklsvsyedstvn..kslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkil

subfamily_CG7180_pd Subfamily CG7180 2170-2434 1.4e-25 84.6 In-house 41-291 (296) alignment
Range on Protein: 2170-2434
Range on HMM: 41-291/296.0
GSLRSNRYRNILATNTNRVRLLGVP--PERDYINADHIVfpDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRdKCYPYWPQVVgeR
  .  ||. ...  . ||| |  .    . ||||| ..      .. .||. ..| . ||..||..| .... .. ..|.  .  . ..  |||.    .
enreknrdvkvvPyDynRvvLekldGeeksdYinavyvd..sflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..k

QTAGDVIVEHLSSysDEFNTVHITELQLYYRsqsrvvrhcqFLSWPDHGVPSDLEDL--VRFQAQVCSCCIAVPMM-LGVVEMfTAMVFLQLETFqAEMP
.  |...|| ...  ...  ..| ...|. .           ..  ..  . . |      || ..      ||.   ...|.   .| |  |    | |
eqygeifveivee..kqyanlkirtfkltkk..........ivalteqekqvkaetRivklfqlteWeledkvPlstnaliel.rrrvrlwrekv.dedp

RPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVL
  .|..|..| |..|||| .  |.  .. .|    ||  .|  .| .||  ... |..  .||  |. ||
eegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2170-2319 1.1e-23 78.7 In-house 40-193 (307) alignment
Range on Protein: 2170-2319
Range on HMM: 40-193/307.0
GSLRSNRYRNILATNTNRVRLLGVPPERDYINADHIVFPDEPHdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQT
     |||... . . .|. .       ||| |...    .|.  |.| |||||..|. .||.|. |. | .. |. .. | .. ||  ||| . |....
antdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpk..kficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklv

AGD----VIVEHLS--SYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPS
 |.    . |. |     . . . . .|.|.. . ..|| ..| |.  |||.||| 
fgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpq

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2171-2263 9.9e-18 59.0 In-house 47-153 (350) alignment
Range on Protein: 2171-2263
Range on HMM: 47-153/350.0
SLRSNRYRNILATNTNRVRLL-GV---------PPERDYINADHIVFP----DEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKC
.   |||.|||  . .||.|  ..             |||||...  .    .   | ||| .|.||. ||.||.... . .|  | ..|...| ...||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

YPYWPQV
| ||.. 
yrYWqeg

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2172-2434 2.2e-40 133.3 In-house 34-267 (283) alignment
Range on Protein: 2172-2434
Range on HMM: 34-267/283.0
LRSNRYRNILATNTNRVRLLGVPPerDYINADHIV-FPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQta
 | ||...|.... .||.|   ..  ||||| .|.   .. .| |||.||.||. || ||| || .. . .| |.|.|||. | ||  |||.   |    
krknrnqeivpadqwrvelksesr..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedy..

GDVIVEHLSSYSDefNTVHITELQLYYR--SQS-RVVRHCQFLSWpdhgvpsdledlvrfqaqvcscciavpMMLGVVEMFTAM-VFLQLETFQAEMPRp
|.  |     ..   |.  | || | .   ..|  .. | |.  |                           .  |   .  ..  | .. . | | .. 
Geftvtlrketts..nsfiikelllrvnssakstlllahyqvidW...........................leygeqaiinslvkfnkvislqteskk.

APLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVL
.|..||||.|.||..| .   .  .. .   . ||  .| |.| ||.| .|||.|. |... .|.. |
gPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqal

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2172-2331 1.8e-34 113.7 In-house 44-201 (515) alignment
Range on Protein: 2172-2331
Range on HMM: 44-201/515.0
LRSNRYRNILATNTNRVRL--LGVPPERDYINADHIvfPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQT
 . |||.|||  ...||.|  .   |. ||.|| .|  |    |  || .|||..|.|.||| .| |. | ||||||.|.|| . ||  |||.. |.   
fkknryknilPydsvrvklevindnPhsdyfnasyi..psfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

AGDVIVEHLSSYSDEFNTvhITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQV
 | . || .|  ..   .  . .|..   ..|| |   .|  |||.||| .   |...  .|
fGsikvelvsleactggi..krkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikev

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2172-2327 4.4e-22 73.1 In-house 57-208 (290) alignment
Range on Protein: 2172-2327
Range on HMM: 57-208/290.0
LRSNRYRNILATNTNRVRLLGvPPERDYINADHIvfpdEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAG
.. |||...   .  || |     . ||. |...    .  .  .|..||.|..|| |.| || |..| .| |. .| | |. || .|.|.  ||  | |
fkknrykdvvcndktrvilkd.GydGdyvhanyv....kGlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

DVIVEHLS-SYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRF
.. |     .  |.    ..  ..     .. ...| .  ||||. |.     |.| 
eitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrt

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2172-2291 2.8e-17 57.2 In-house 53-170 (310) alignment
Range on Protein: 2172-2291
Range on HMM: 53-170/310.0
LRSNRYRNILATNTNRVRLL-GVPPERDYINADHIVFpdEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQvVGERQTA
.  ||| ...  .| ||.|        ||| |...    .     .| .||||| |. ||| |. |.   .| .. .  | || ||  |||  .|  .| 
mhknrysdvvcldtsrvklkidksryedyihanyvkt..nylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps.lgvtety

GDVIVEHLSSYSDEFNTVHIT
| . |  ||  |.||. . ..
gcirvtnlsesseefeicnla

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2172-2320 6.6e-17 56.5 In-house 9-155 (239) alignment
Range on Protein: 2172-2320
Range on HMM: 9-155/239.0
LRSNRYRNILATNTNRVRL--LGVPPERDYINADHIVFPDEpHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGeRQT
   ||| ||.. . .|| |  |   |  ||||| ..   |      || .|| ....  ||| |. |.    | |.| | || . ||. |||.    .  
kaknryanivtydhsrvvleklsndphsdyinasylrdydg.spkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.kyc

AGDVIVEHLSSYSDEFNTVHIteLQLYYRSQSRVVRHCQFLSWPDHGVPSD
   | . .   ..|      .  .    ... | | . .|  |||.|||  
nlrvtlrktevfadyiirtfv..msqvgqteeryvyqyhftvwpdkgvpqy

Y_phosphatase Protein-tyrosine phosphatase 2173-2430 2.7e-60 199.1 Pfam-A 3-234 (235) alignment
Range on Protein: 2173-2430
Range on HMM: 3-234/235.0
RSNRYRNILATNTNRVRLLGVPPERDYINADHIVFPDEphDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGD
. |||..||. . .||.| | . . ||||| ..   .|  . |.|..||||. |..||| || |. | .|.|.|.|.| || || .|||.  .| .| ||
kknRykdilpydktrvklkgsegpsdYInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

VIVEHLSSYSDEFNTVHITELQLYYRSQS---RVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCiavpmmlgvvemftamvflqletfqaeMPRPAPL
. ||  .. ... . . ...|.|  . ..   | |.. .. .|||||||.. ..|...  .| .                              .. .|.
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...........................eaksgpv

LVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
.|||||||||.|..|. |.. .. ...  .||  .|. .|.|||. .|.|||.  ||.  |
vVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 2173-2430 2.7e-60 199.1 In-house 3-234 (235) alignment
Range on Protein: 2173-2430
Range on HMM: 3-234/235.0
RSNRYRNILATNTNRVRLLGVPPERDYINADHIVFPDEphDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGD
. |||..||. . .||.| | . . ||||| ..   .|  . |.|..||||. |..||| || |. | .|.|.|.|.| || || .|||.  .| .| ||
kknRykdilpydktrvklkgsegpsdYInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

VIVEHLSSYSDEFNTVHITELQLYYRSQS---RVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCiavpmmlgvvemftamvflqletfqaeMPRPAPL
. ||  .. ... . . ...|.|  . ..   | |.. .. .|||||||.. ..|...  .| .                              .. .|.
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...........................eaksgpv

LVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
.|||||||||.|..|. |.. .. ...  .||  .|. .|.|||. .|.|||.  ||.  |
vVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

0041856 (Phosphotyrosine protein) phosphatases II 2173-2434 8.5e-37 121.9 In-house 3-172 (182) alignment
Range on Protein: 2173-2434
Range on HMM: 3-172/182.0
RSNRYRNILATNTNRvrllgvppERDYINADHIVFPDEPHDlkYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTqlqeggrdkCYPYWPQVVgerqtagd
  |||..||  . .|          |||||  ....  . .  .|..||||. ||.||..|. ..|..|| ..|         ...|||. .        
dknrysdilpydhsr........dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywpell........

vivehlssysdefntvhitelqlyyrsqSRVVRHCQFLSWPDHGVPSdLEDLVRFQAQVCScciavpmmlgvvemftamvflqletfqaempRPAPLLVH
                             | . . ..|.|||||||. |..|..|  .| .                               .. | |||
............................erlgiqylylpwpDhgvpd.ldelldfieevle...............................eggpvlVH

CSAGVGRSGVVVLSDVIANKtrkGyiPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVL
|||||||.|..|. ...  .   |   ...  |. |||.||. ..|..|. .|....| ..|
CsaGvgRtgtlvaaylmkkl...g..vsleeavklvrsrRpgmvitpnqyfflqlallelll

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2173-2319 2.6e-27 90.2 In-house 57-205 (305) alignment
Range on Protein: 2173-2319
Range on HMM: 57-205/305.0
RSNRYRNILATNTNRVRLlGVPPERDYINADHIVFPDEPhDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTA-G
  |||... . . . |.|   |.  ||| |...  |  | . ..| |||||. |...|| || |. |  | |. .  | |. ||  |||   ||...  .
tknryqdvpcqdqsavkl.dkpspsdyihanyvgcpmip.ekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelks

DVIVEHLSSY--SDEFNTVHITELQLYY-RSQSRVVRHCQFLSWPDHGVPS
 ..|| .|     .  . ..|| |.| |  .|.  ||| |.  ||| ||| 
givvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvpp

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2173-2329 2.8e-24 81.0 In-house 63-212 (319) alignment
Range on Protein: 2173-2329
Range on HMM: 63-212/319.0
RSNRYRNILATNTNRVRLLGVPPE--RDYINADHIVFPDEPHdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTqlqeggRDKCYPYWPQVVGERQTA
  ||. |||| . |.|.|  .  |   ||||| ..     .   ||| |||||. |..||| |. .. . || ..|      .|||  |||. . ...  
dknriinilafdknvvklerliGeefsdyinasfvtGyqrkd..kyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeer

GDVIVEHLSsYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQA
..| |. .   ..|.   .|   .     . | ..   || |||.|||    ||.|.  
fkvkvdsve.etaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvk

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2173-2320 1.4e-23 78.3 In-house 49-192 (287) alignment
Range on Protein: 2173-2320
Range on HMM: 49-192/287.0
RSNRYRNILATNTNRVRLLGVPPerDYINADHIVFPDEphDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGerQTAGD
  ||...||  . .|| | |  |  ||||| .|    |  . ..|.|..|.  |. .|| .. .. | .| |..|..|  ...|| |||.      . |.
dknRltqilvpdnyrvllkgehp..dyinavfidgyke..kkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGe

VIVEHLSSYSDEFNTVHITELQLYYRS-QSRVVRHCQFLSWPDHG-VPSD
  .| |.    .  ..   |..   .. . . |.  |. .|...| |.. 
yniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtep

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2173-2324 1.1e-18 62.0 In-house 50-208 (305) alignment
Range on Protein: 2173-2324
Range on HMM: 50-208/305.0
RSNRYRNILATNTNRVRLLGVPPeRDYINADHIVFPDEPHdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGE----RQ
  |||...   . |||.| |  |  .|| |...  | .|.  ..| .| ||. |  ||| |  |. | .| |. .|.| |  ||. |..   ..    ..
gknrykdvgcldnnrvklegpwp.heyihanyvstptnpk..rfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee

TAGDVIVEHLSSYSDEFNT---VHITELQLYY---RSQSRVVRHCQFLSWPDHGVPSDLEDL
    ..|   || . .|..    ..|| .|      ...| | |  .  ||| |||.    .
kgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlai

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2173-2320 7.5e-17 56.3 In-house 9-154 (239) alignment
Range on Protein: 2173-2320
Range on HMM: 9-154/239.0
RSNRYRNILATNTNRVRL--LGVPPERDYINADHIVFPDEpHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGeRQTA
  ||| ||.. . .|| |  |   |  ||||| ..   |      || .|| ....  ||| |. |.    | |.| | || . ||. |||.    .   
aknryanivtydhsrvvleklsndphsdyinasylrdydg.spkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.kycn

GDVIVEHLSSYSDEFNTVHIteLQLYYRSQSRVVRHCQFLSWPDHGVPSD
  | . .   ..|      .  .    ... | | . .|  |||.|||  
lrvtlrktevfadyiirtfv..msqvgqteeryvyqyhftvwpdkgvpqy

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2173-2329 4.8e-13 43.3 In-house 50-201 (439) alignment
Range on Protein: 2173-2329
Range on HMM: 50-201/439.0
RSNRYRNILATNTNRVRLLGVP--PERDYINADHIVFPdePHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRdkcypYWPQvvGERQTA
  |||... | .  || |  .|  |   ||||..|       |  || .||| . |..||| .| .. . || |.|.| |  .     |||    .    
tknrykdvgafdhtrvtlqeipgvphshyinanyikGy..yddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywps..daevcy

GDVIVEHlsSYSDEFNTVHITELQLYYR----SQSRVVRHCQFLSWPDHGVPSDLEDLVRFQA
||..|        |.    |  .... .     . | | . ....|||. ||..   .. |  
gdiavrv..drnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflr

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2174-2333 2.4e-27 90.7 In-house 6-164 (237) alignment
Range on Protein: 2174-2333
Range on HMM: 6-164/237.0
SNRYRNILATNTNRVRLLGVPPERDYINADHIVFPDEpHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVvGERQTAGDV
 ||| || | . .|| | |   . ||||| ..   |     ||| |||||... .||| || |.    | |.| | || . ||. |||.   . .. | .
knrygnivaydhsrvvlkgagsgsdyinatylkgfdg.tpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaaygvl

IVEhLsSYSDEFNTVHITELQLYYRSQS---RVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCS
 |  |    .||    .  | | .| .    |..   || ||||.|||     |.||. ..  
tvs.l.kkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniin

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2174-2330 6.5e-24 79.9 In-house 28-177 (284) alignment
Range on Protein: 2174-2330
Range on HMM: 28-177/284.0
SNRYRNILATNTNRVRLLGVPPE--RDYINADHIVFPDEPHdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTqlqeggRDKCYPYWPQVVGERQTAG
 ||. .||| . |.|.|  .  |   ||||| .|     ..  ||| .||||. |..||| |. .. . || ..|      .|||  |||. . ...  .
knrighilafdknvvklerliGeefsdyinasfitGyqrkd..kyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerf

DVIVEHLSsYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQ
.| |. ..  |.|.   .|   .     . | .|   || |||.|||    ||.|.  .
kvkvdsve.eseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkk

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2174-2335 2.7e-22 74.1 In-house 46-204 (288) alignment
Range on Protein: 2174-2335
Range on HMM: 46-204/288.0
SNRYRNILATNTNRVRLLgvpPERDYINADHiVFPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGDV
 .||.|.   .. ||.|     . |.  | . |.. .... . | || ||..|.. .| |. ...|  | |...| | |..|   |.| ..||.   | .
rdryenlprcditrvkls...ddpdfyiaan.vvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl

IVEHLSSYSDEFNTVHITELQLYYRSQSRV-VRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCC
      ...|   .|... |.     . .| |..  .| |.|.||| .    .|.   . |. 
ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq

subfamily_CG42327_pd Subfamily CG42327 2174-2331 2.3e-16 54.4 In-house 31-190 (319) alignment
Range on Protein: 2174-2331
Range on HMM: 31-190/319.0
SNRYRNILATNTNRVRL--LGVPPERDYINADHIVFPDEPHDlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVG--ERQT
 .|. |..     || |   |  ..  |..|...  .|. .   || || .|. .  ||| .| .|   .|  .|.|.| | ..|  |.|   .  ....
ksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapn.syiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

AGDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFlSWPDHGVPSDLEDLVRFQAQV
 ||. |      ...   .    |.   ...|| . |  .  |.. .||.. . |.    .|
yGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllev

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2174-2326 1.5e-15 52.0 In-house 38-191 (285) alignment
Range on Protein: 2174-2326
Range on HMM: 38-191/285.0
SNRYRNILATNTNRVRLLGvpPERDYINADHIVFPDEPhDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGDV
 ||| .. . .  || |     .|||| |  . .| .  .  || .||||  |..||| |. |. .  . |.  | ||| .||  |.|. .||    |  
lnryadvrcieetrvvlkn..hdrdyihaswmrmpgkd.qstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgky

IVEHLSSYSDEF-----NTVHITELQlYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVR
 .       .       |.. ... .    |.   . | |   |||.  | |   .. 
eitlteckeeaiagtilnaltvinte.dasseplymnhvqvpwwpdqlapedarpmie

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2174-2301 3.1e-12 41.1 In-house 36-154 (267) alignment
Range on Protein: 2174-2301
Range on HMM: 36-154/267.0
SNRYRNILATNTNRVRLLGvpPERDYINADHIVFPDepHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLqegGRDKCYPYWPQVVGERQTAGDV
 ||. . |  . .|| |     |..|||| ..         ..|. |.||. |. ||.|.. .|.| .| ..|.    . |.   .||  .|. .   |.
rnrlddnlpyddtrvilrt..keeeyinasyvegyk..tknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdnirlfwPPkmgqakkyqdl

IVEHlsSYSDEFNTVHITELQLYYRSQS
 |||  |   | |  .|  |.| .. .|
tveh..slekeendyqiitlelkfknes

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2175-2327 4.1e-12 40.4 In-house 47-201 (312) alignment
Range on Protein: 2175-2327
Range on HMM: 47-201/312.0
NRYRNILATNTNRVRLLGvpPERDYINADHIVFPDEPHdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGD-V
||| ||   .  |  | |   |  || |. .     |   ... .||||. |.  || ..   |  .| ... . | | .||  |  ..||  .     |
nrypniqcwdrgrftlag..denfyihanfvkictkpe..rfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

IVE-----HLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRF
  |      .   | .  |  .  . .    |   . | |. ||||||.|   .   |.
yteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrl

0046846 (Phosphotyrosine protein) phosphatases II 2187-2430 1.8e-32 107.9 In-house 2-170 (176) alignment
Range on Protein: 2187-2430
Range on HMM: 2-170/176.0
RVRLLGVPPERDYINADHIVFPdephdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQtagdvivehlssysdefn
|.|||| ..  |||||. |. .      ..|  ||||  |. ||. |. ..|.... ..|...| || ||. |||.. ..                    
rlrllgldldldyinanlilgs......rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..................

tvhitelqlyyrsqsrvvrHCQFLSWPDHGVPSDlEDLVRFQAQVCSCCiavpmmlgvvemftamvflqletfqaemPRPAPLLVHCSAGVGRSGVVVLS
                   . ..| |||||||.. |.| .. ... ..                              .  | |||||||.||.|..|. 
...................qylhlpwpDhgvpdl.elllellefireal............................keggpvlVHCsaGigRtgtlvaa

DVIANktrkGYIPDVRTMVSIVRSQRP-MTIQTLEQFTLLYDFAL
. .      ..  .|   .. ||.||| . .|| ||   ||.|.|
yllel....ekglsveealalvreqRplgavqtpeQyrflyefel

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 2193-2244 3.1e-07 24.2 In-house 66-115 (347) alignment
Range on Protein: 2193-2244
Range on HMM: 66-115/347.0
VPPERDYINADHIVFPDEphDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAM
  .   |||| || | .   . .||..| ||  || ||| ||    |  .  
addvetyinashikfdna..skeyiltqyplpdtvrdfwkmvsvtkvtqvvt

0044763 (Phosphotyrosine protein) phosphatases II 2195-2431 2e-26 88.1 In-house 16-169 (178) alignment
Range on Protein: 2195-2431
Range on HMM: 16-169/178.0
PERDYINADHIVfpdePHdlKYIMAQGPlqatvNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGerqtagdvivehlssysdefntvhitelq
.  |||||..|.    |.   |.....|      |.. .. ..|...| ..|. .|.|. ||.||||.  |                             
ersdyinaseil....pg..lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.............................

lyyrsqsrvvRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCiavpmmlgvvemftamvflqletfqaeMPRPAPLLVHCSAGVGRSGVVVLSDVIANKtr
           . ... .||||||. || . .| . . ..                             ... | ||||||||||||..|. . .     
..........iqylhipipDhgvpdllehflefvefieeal...........................dekggpvlVHCsaGvgRsgtlvaaylmkkl..

kGYipDVRTMVSIVRSQRPmTIQTLEQFTLLYDFALK
 |.  ..   .. ||..||  ... .|   ||.|.|.
.gl..sleeaielvrerRp.ivpnpgqlrqLyefelr

0043147 (Phosphotyrosine protein) phosphatases II 2196-2429 1.7e-32 107.9 In-house 4-157 (172) alignment
Range on Protein: 2196-2429
Range on HMM: 4-157/172.0
ERDYINADHIVFPDEPHDlkYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLqeggrdkcypywpqvvgerqtagdvivehlssysdefntvhitelQL
 .||||| .. ..  |..  .|. ||||. |..||| |. ..|...| ..|.|                                             ..
gsdyinasyldlyyipdr..fiatqgplrntladfwrmlkelgithivnltel.............................................ly

YYRSQSRVVRHCQFLSWPDHGVPsDLEDLVRFQAQVCSCCIAVPmmlgvvemftamvflqletfqaemprPAPLLVHCSAGVGRSGVVVLSDVIAnktrK
..   .| . . ..|.||||||| .|| | .|  .. . ..  |                            | ||||||||||.|..|. . .     .
dpellerlgiqylylpwpDhgvp.llellleflefidellalsp..........................ggpvlVHCsaGvgRtgtlvaaylml....l

GYipDVRTMVSIVRSQRPMTIQTLEQFTLLYDFA
|.  ..   |. ||..||. .|. .|  .||.|.
gl..sleeavalvrekRpgavqnpsqyrflyyfe

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2196-2262 5.3e-11 36.4 In-house 89-155 (349) alignment
Range on Protein: 2196-2262
Range on HMM: 89-155/349.0
ERDYINADHIVFPDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQ
  |||||... ..    . |||  | || .||.||....  .||  .  ... .| . .||. || .
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2196-2326 2.5e-09 31.7 In-house 45-182 (290) alignment
Range on Protein: 2196-2326
Range on HMM: 45-182/290.0
ERDYINADHIVFPdepHDLKYIMAQGPLQAT-------VNDFWTMVAQQGVGTIAMVTQLQEGGRD----KCYPYWPQVVGERQTAGDVIVEHLSSYSDE
  ||| |... .|   ..|. |. | |....       ...|| |. |  |  . |. . .|  ..     |  | |. |||  . ... |.  |   ..
nddyiHAnrvtcp...nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskeked

fnTVHITELQLYYRSQS-RVVRHCQFLSWPDHGVPSDLEDLVR
   | . || . .  .    | | .. .| .  |. |   |. 
..dvetRelvvkfddeeeftvtHsllkgWnklnvqedtktlls

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2197-2320 1.2e-15 52.1 In-house 75-199 (301) alignment
Range on Protein: 2197-2320
Range on HMM: 75-199/301.0
RDYINADHIVFPDEPHdlKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGDVIVEHLSSY---SDEFNTVHITEL
|  | |. |  . .||  ..| .||||..| .|||.|. |  | .|.|..|  |   .||  | |. ..|.   |   ..  ..    ... .  ..   
rvPihanwiptsGhph..rfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtleve

QLYYRSQSRVVRHCQFLSWPDHGVPSD
    . ..| | | |. .|.|.|||  
dstgkfatrtvthyqysewtdrgvPks

0051429 (Phosphotyrosine protein) phosphatases II 2198-2433 2.3e-36 121.2 In-house 5-225 (272) alignment
Range on Protein: 2198-2433
Range on HMM: 5-225/272.0
DYINADHIVFPdephdL------KYIMAQGPLQATVNDFWTMvAQQGVGTIAMVTQLQEGGRDKCYPYWP----------QVVGERQTAGDVIVEHLSSY
.|||| ..  .            ... ..|||..|..|||.. ...|. || ..... | ||.||..|||            . .. . |.. | .|| .
gyiNardvggy.....grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee

SDEFNTVHITELQLY-YRSQSRVVRHCQFLSWPDHGVPSDLedLVRFQAQVcscciavpmmlgvvemftamvflqletfqAEmprPAPLLVHCSAGVGRS
  .. ..   .| |. . ...| |.| ....|||||||..   |... ...                             ..   . |.|||||||..|.
llldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellell.............................ld...ggpvlvHCsaGkdRT

GVVVLSDVIANKTRKGYIPD--------VRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKV
|.||. . ..    .  | |        ..  |. .|.|||  .|| ||.  ||...|. .
GtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallell

0036282 (Phosphotyrosine protein) phosphatases II 2198-2428 1.2e-32 108.4 In-house 3-165 (174) alignment
Range on Protein: 2198-2428
Range on HMM: 3-165/174.0
DYINADHIVFPDEPHdlKYIMAQGPLQatvndFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQvvgerqtagdvivehlssysdefntvhitelqlYY
||||| .. .   .   ..|  ||||.     || |. ..|. |. |.....| |. ||. |||                                  ..
dyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lr

RSQSRVVRHCQFLSWPDHGVPSDLEdLVRFQAQVCSCCiavpmmlgvvemftamvflqletfqAEmPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRkGY
 . .| . . ..| |||||||.. . | .|  .| ...                         .| ..  |.||||||||||.|..|. . .    .   
edlerlgiqylylpwpDhgvpdlsi.llefvkfveeal.........................se.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.es

IPDVRTMVSIVRSQRPMTIQTLEQFTLLYDF
  |.  .|  .|.|||. .|| .|.  ||.|
lvdaldlvrelRlqrpgmvqtpsQyrflyyf

0051082 (Phosphotyrosine protein) phosphatases II 2198-2427 3.1e-23 77.5 In-house 4-147 (151) alignment
Range on Protein: 2198-2427
Range on HMM: 4-147/151.0
DYINADHIVfPDephdlkYIMAQGPLQatvnDFWTMVAQQGVGTIAMVTQLQEGGrdKCYPYWPQVVgerqtagdvivehlssysdefntvhitelqlyy
||||.  .  .       ..  .|||.    ||. .....|. || ......| |  .|. |.|.                                   
dyinfsyvt.gg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

rsqsRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCScciavpmmlgvvemftamvflqletfqaemPRPAPLLVHCSAGVGRSGVVVLSDVIANKtrkgy
    . |.|...|.|||.|.|  .. ...|  .. .                              ... |.|||||||.||.|..|. . .. .     
....ievlhipildwpdpglplsfdavleflellld..............................kkngpvlvHCsaGkgRTGtlvalylmllg.....

iPDVRTMVSIVRSQRPMTIQTLEQFTLLYD
  .. . .. .|..||. .|. .|| ... 
.vsleealeeyrlkrpgvvqpnqqflfqlf

subfamily_egg_pd Subfamily egg 2198-2429 1.5e-14 48.4 In-house 69-266 (307) alignment
Range on Protein: 2198-2429
Range on HMM: 69-266/307.0
DYINADHIVfpDEPHDLKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGgrDKCYPYWPQVVGERQTA--GDVIVEHLSSYSDEFNTVHITELQL
|.| |...    .|   ..|.|| ||. ||.||| || |. |  | |.|  .|   ..|  |||.   .      | . .| |  .|      ..|.|.|
dfihanrvk..Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl

YYRSqsrvvrhcqflswpdhgvpsdledlvrfqaqvcSCCIAVPMMLGVVEMFtAMVFLQLETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRK
                                          .    | |.   . |.  |. ..       | .|..  || .....|  ..   .  .
vGgd.................................deerflehwqgdvnns.sdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiallsllr

GYIP--DVRTMVSIVRSQRPMTIQTLEQFTLLYDFA
| |    |.  |  .| .|......  .. ..|   
Gpitkslvlravvflrlrrrlsvesvllylfvyrlv

subfamily_hpo-7_pd Subfamily hpo-7 2206-2324 1.2e-09 32.5 In-house 28-144 (263) alignment
Range on Protein: 2206-2324
Range on HMM: 28-144/263.0
VFPDEPHDLKYI--MaqgpLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGDVIVEHLSSYSDEF-NTVHITElQLYYRSQSR
. |. ... | .  .    |  |.. |. .. |..  ...|..  .| |..||  |.|    |.|   .| |    . ||    | .... .|  . . .
fkPekdkkrknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlells.tlgeKkkth

VVRHCQFLSWPDHGVPSDLEDL
 |.| ..  |...  | . .. 
tvkhysykgWiekndpelarei

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2207-2325 9.8e-11 36.2 In-house 26-139 (255) alignment
Range on Protein: 2207-2325
Range on HMM: 26-139/255.0
FPDEPHDLKYI--MaqgplqaTVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGDVIVEHLSSYSDEF-NTVHITeLQLYYRSQSRV
 |. ... | .  .       ||. |. .. |..  ...|.. ..| |..||  |.|    |..   || |    | .|    |..|| ..|  . . . 
kPekdkkrknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleit.stlgekkktht

VRHCQFLSWPDHGVPSDLEDLV
|.| ..  |...  | . ... 
vkhysykGWieknaPelareil

0049260 (Phosphotyrosine protein) phosphatases II 2214-2428 4e-30 99.9 In-house 9-145 (152) alignment
Range on Protein: 2214-2428
Range on HMM: 9-145/152.0
LKYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWpqvvgerqtagdvivehlssysdefntvhitelqlyyrsqsrvvrHCQFLSWP
 ..| .|||.  |..||| |. ..|..|| |.|.|.| |..||. |.                                             . ..| ||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpwp

DHGVPSDLEDLVRFQAQVCSCCIAVPMmlgvvemftamvflqletfqaemprpaPLLVHCSAGVGRSGVVVLSDVIAnktrkgYIPDVRTMVSIVRSQRP
|||||.. . |  .   .  ...                               | ||||||||||.|..|. . .       .  ..   |. ||..||
Dhgvpdlsqlllflllfieklaldkgg...........................pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRp

MTIQTLEQFTLLYDF
. ... .|  .||.|
gavpnpgqlrflyef

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2215-2318 2.3e-09 31.7 In-house 6-111 (199) alignment
Range on Protein: 2215-2318
Range on HMM: 6-111/199.0
KYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGD--VIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSW
.|| .| ||. |. ||| || . | | | || . |         ||| .       |   | .. ... .|   |. |   .      .| . | || ||
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGVP
 ..  |
kekttp

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2215-2318 2.3e-09 31.7 In-house 5-110 (198) alignment
Range on Protein: 2215-2318
Range on HMM: 5-110/198.0
KYIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGD--VIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSW
.|| .| ||. |. ||| || . | | | || . |         ||| .       |   | .. ... .|   |. |   .      .| . | || ||
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGVP
 ..  |
kekttp

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2216-2315 1.1e-10 35.5 In-house 238-331 (440) alignment
Range on Protein: 2216-2315
Range on HMM: 238-331/440.0
YIMAQGPLQATVNDFWTMVAQQGVGTIAMVTQLQEggrDKCYPYWPqVVGERQTAGDVIVEHLSsySDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDH
.| .| ||..|| ||| .| .  . || |. ||..     |  ||| |     | |   | |    |...| |..  |.| |. .   .|  .  .||  
fiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywp.vntrsvtfgpftvghkg..senmnrvkvrtlelkykeevheirqfevqtwptw





subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2221-2321 1.3e-08 28.6 In-house 98-207 (302) alignment
Range on Protein: 2221-2321
Range on HMM: 98-207/302.0
GPLQATVNDFWTMVAQQGVGTIAMVTQLQEGGRDKCYPYWPQVVGERQTAGDVI------VEHLSSYSDEF----NTVHITELQLYYrSQSRVVRHCQFL
 | . |.. .|... |  |. .. .... |..  || .|. . ||.. . |          ..|. ..|       || |.. .     . . |   .| 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkk.kvkktvdilafs

SWPDHGVPSDL
.||||| | . 
awpdhGapkea

0048076 (Phosphotyrosine protein) phosphatases II 2258-2430 2.4e-20 68.1 In-house 1-140 (145) alignment
Range on Protein: 2258-2430
Range on HMM: 1-140/145.0
PYWPQVVGERQTAGDVIVEHLSSYSDEFNTVHITELQLYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVcscciavpmmlgvvemftamvflqle
||||. . ..   |.. . .   .  ...  ..  |  . .  .| . . ..|.|||||||..||.| .| ...                          
pywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefi..........................

tfQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANktrKGyiPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
  .. .... | ||||||||||.|..|. ...     .|   ..   .  ||||||. ... .|.  ||.| |
..eealkeggpvlVHCsaGvgRtgtlvaaylmll...lg..vsleealelvrsqrpgavpnpgqlrflyefel

0048179 (Phosphotyrosine protein) phosphatases II 2285-2428 7.5e-18 60.1 In-house 28-140 (144) alignment
Range on Protein: 2285-2428
Range on HMM: 28-140/144.0
FNTVHITELQ--LYYRSQSRVVRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCciavpmmlgvvemftamvflqletfqaeMPRPAPLLVHCSAGVGRSGV
..  ..  |.   .. .  | . . ..|.|||||||..||.| .| . . ..                            .... | ||||||||||.|.
lgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieea............................leeggpvlVHCsaGvgRtgt

VVLSDVIAnktRKGyiPDVRTMVSIVRSQRPMTIQTLEQFTLLYDF
.|. ...    ..|   ..   .  |||.||. ... .|.  |...
lvaaylmk...klg..lsleealalvrsrrpgavpnpgqlrfLley

PTPc_DSPc_SM00012 2304-2429 8e-22 72.8 In-house 2-103 (105) alignment
Range on Protein: 2304-2429
Range on HMM: 2-103/105.0
VRHCQFLSWPDHGVPSDLEDLVRFQAQVCSCCIAVPMmlgvvemftamvflqletfqaemprPAPLLVHCSAGVGRSGVVVLSDVIANKTRKG-YIPDVR
|.| ....|||||||.. ...... ..| ..  .                             .|..|||||||||.|..|. |.. .. .|. . .|. 
vkhyhytgwpdhgvPeesdsilellravkknknkses.........................skpvvVhCsaGvgRtgtfvaldillqqleketkevdif

TMVSIVRSQRPMTIQTLEQFTLLYDFA
 .|. .|.||| ..||.||.  ||.  
qivkelrkqRpgmvqteeqylflyral

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2342-2426 1.2e-10 35.9 In-house 149-233 (239) alignment
Range on Protein: 2342-2426
Range on HMM: 149-233/239.0
LGVVEMFTAMVFLQLETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLY
 || .  ||.. |. .  .  .|   | ..||||||||.| ... | .  ...|    |.   |  .| .||  .|| ||. ...
kgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2342-2426 1.3e-10 35.9 In-house 150-234 (239) alignment
Range on Protein: 2342-2426
Range on HMM: 150-234/239.0
LGVVEMFTAMVFLQLETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLY
 || .  ||.. |. .  .  .|   | ..||||||||.| ... | .  ...|    |.   |  .| .||  .|| ||. ...
kgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2343-2429 4.5e-14 47.3 In-house 192-279 (305) alignment
Range on Protein: 2343-2429
Range on HMM: 192-279/305.0
GVVEMFTAMVFLQLETFQAEMPR-PAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFA
||... |... |  .  .. .     ||||||||||||.|| .  |.  .. .|  . ||  ..  .||.|.  .|||.|.. |.|  
GvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdal

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2348-2432 1.2e-12 42.5 In-house 189-275 (281) alignment
Range on Protein: 2348-2432
Range on HMM: 189-275/281.0
FTAMVFLQLETFQAEMPRP-APLLVHCSAGVGRSGVVVLSDVIANKT-RKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKK
 ....  . |  ... ..  |||..||||||||.|. .  | ....  ..    ||. .|  .| .| . .||. |.. .|   |. 
tkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2348-2429 2.8e-08 27.5 In-house 200-281 (302) alignment
Range on Protein: 2348-2429
Range on HMM: 200-281/302.0
FTAMVFLQLETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFA
.....    . |. ...  .....    |.|| |...   |  .|  ||  | .  .|  .||||| ....|.|.. ||  .
yaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyial

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2350-2430 3.8e-08 27.4 In-house 246-341 (350) alignment
Range on Protein: 2350-2430
Range on HMM: 246-341/350.0
AMVFLQLETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIAN----------KTRKGYIP-----DVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
 ..         .  | .|.|||||||||| |..|  | . .          . ||   .      .  .| ..|.||   .|.|.||  .|. .|
dliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2357-2433 7e-14 46.6 In-house 164-242 (250) alignment
Range on Protein: 2357-2433
Range on HMM: 164-242/250.0
ETFQAEMPR--PAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKV
.  ||. ..   ||..|.|||||||||  .  | . .. .|  . ||. .. ..| .|| ....|||.  .|  .|| .
kkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal

subfamily_PTPRB_pd Subfamily PTPRB 2357-2430 1.1e-12 42.6 In-house 209-282 (293) alignment
Range on Protein: 2357-2430
Range on HMM: 209-282/293.0
ETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
.. . .  . .|..|||||||||.|. .  | . .. ..  . |. ..|. .|..| . .|| .|.  ...  |
reaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvl

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2357-2430 3.7e-11 37.9 In-house 215-288 (319) alignment
Range on Protein: 2357-2430
Range on HMM: 215-288/319.0
ETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
. ..  .  .|...|||||||||.|| .  ||. .. ..    ||  .|  .| ||.  .| | |. ..|   |
rhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2357-2430 4.9e-11 37.7 In-house 179-252 (284) alignment
Range on Protein: 2357-2430
Range on HMM: 179-252/284.0
ETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
. ..  .  .|...|||||||||.|| .  ||. .. ..    ||  .|  .| ||.  .| | |. ..|   |
rhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2357-2430 9.3e-09 29.4 In-house 210-284 (305) alignment
Range on Protein: 2357-2430
Range on HMM: 210-284/305.0
ETFQAEMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGY-IPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
| ..   |   |. ||||||.||.| ||. . | ..   |  | |   ..  .| ||  .||| .|. ....  |
ellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvil

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2362-2434 7.5e-10 32.7 In-house 123-195 (440) alignment
Range on Protein: 2362-2434
Range on HMM: 123-195/440.0
EMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVL
|    .|||||||||.||.||..  | |  ....    |. .... .|..||  .|| ||......  |. .|
ekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavlegll

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2362-2427 2.6e-09 31.7 In-house 168-233 (237) alignment
Range on Protein: 2362-2427
Range on HMM: 168-233/237.0
EMPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYD
 ... .| ..||||||||.|.... | .  ....  . |.   |  .  .||  ||| .|. ....
hvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihq

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2363-2433 1.7e-11 38.6 In-house 208-278 (287) alignment
Range on Protein: 2363-2433
Range on HMM: 208-278/287.0
MPRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKV
 .  ....||||..||||.. .  ..  ||...  . ||  ..   | |.| ..|| ||.. ..|  |. .
krgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2363-2435 1.3e-07 25.5 In-house 218-291 (305) alignment
Range on Protein: 2363-2435
Range on HMM: 218-291/305.0
MPRPAPLLVHCSAGVGRSGVVVLSDVIANKT-RKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVLE
     |..||||||.||.| .|  . | .|   .   | .  .|  .| || ..||.  |.  ..   |. .||
rgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfle

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2364-2433 7.2e-14 46.6 In-house 214-283 (319) alignment
Range on Protein: 2364-2433
Range on HMM: 214-283/319.0
PRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKV
.   |. ||||||||| |  .  |.. .. ..  . || ..|| .| ||.. .|. ||....|.  |. |
tqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleav

subfamily_PTPN12_pd Subfamily PTPN12 2364-2428 9.1e-14 46.0 In-house 205-272 (290) alignment
Range on Protein: 2364-2428
Range on HMM: 205-272/290.0
PRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIP---DVRTMVSIVRSQRPMTIQTLEQFTLLYDF
   |||.||||||||| |...  | . .  ... ||   ||  .|  .| ||.  .|| ||..|.|  
sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvyka

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2364-2432 9.3e-14 46.2 In-house 211-279 (318) alignment
Range on Protein: 2364-2432
Range on HMM: 211-279/318.0
PRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKK
.   |..||||||||| || .  |.. .. ..  . ||  .|. .|.||.. .|| .|....||  |. 
sgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllea

subfamily_PTPN13_pd Subfamily PTPN13 2364-2431 3.8e-12 41.1 In-house 199-267 (273) alignment
Range on Protein: 2364-2431
Range on HMM: 199-267/273.0
PR-PAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALK
 .  .|..||||||.||||...  ||. .   .    ||. .|  .| ||   .|| .|. . |  .|.
qtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2364-2436 1.6e-11 38.7 In-house 214-286 (290) alignment
Range on Protein: 2364-2436
Range on HMM: 214-286/290.0
PRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVLEV
.   ...||||..||||.| .  ..  ||...    ||  ..   |.|.| ..|| .|. ....  |. . ..
rgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2364-2429 3.4e-08 27.5 In-house 198-265 (281) alignment
Range on Protein: 2364-2429
Range on HMM: 198-265/281.0
PRPAPLLVHCSAGVGRSGVVVLSDVIANKTRKG-YIPDVRTMVSIVRS-QRPMTIQTLEQFTLLYDFA
 | .| ..|||||||||| ..  ..  .  .    .||.. .|| .|   |  ..|||.|. |..   
arstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl

subfamily_PTPRN_pd Subfamily PTPRN 2365-2431 5.4e-11 36.8 In-house 223-290 (297) alignment
Range on Protein: 2365-2431
Range on HMM: 223-290/297.0
RPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYI-PDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALK
| .|..||||.|.||.|| .| |.. |.  ||    |. . .  .| |||  ..| .|| . .    .
rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2365-2426 9.6e-07 22.6 In-house 222-283 (310) alignment
Range on Protein: 2365-2426
Range on HMM: 222-283/310.0
RPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLY
|  | .||||||..| .|||  ..  .|...|   |.  ... .. .| . |||  |.... 
rhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliid

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2365-2428 3.7e-06 20.8 In-house 215-278 (290) alignment
Range on Protein: 2365-2428
Range on HMM: 215-278/290.0
RPAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDF
 . |. ||||||.||.|  |  .| ..   .|   |.  .|  .|  |  ..|   |. .| . 
asGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalvei

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2366-2433 2.9e-13 44.4 In-house 210-277 (315) alignment
Range on Protein: 2366-2433
Range on HMM: 210-277/315.0
PAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKV
  .|||||||||||.|||.  | . .. ...   ||  .| ..|..||  .|| |.....||  |...
efsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2366-2432 2.5e-12 41.6 In-house 223-289 (298) alignment
Range on Protein: 2366-2432
Range on HMM: 223-289/298.0
PAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKK
 .|..|.|||||||||  .  | . .. .|    ||. .| ..| .|| ..|| ||.. .|.  |. 
nkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2366-2435 3.3e-12 40.7 In-house 226-294 (301) alignment
Range on Protein: 2366-2435
Range on HMM: 226-294/301.0
PAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFaLKKVLE
 .|..||||..|.|||| .  ..     .   . ||  ..  || ..|  ..||||.| .||  ... |.
ggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydv.idmylq

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2366-2430 1.1e-11 39.3 In-house 212-276 (288) alignment
Range on Protein: 2366-2430
Range on HMM: 212-276/288.0
PAPLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
  |..|||||||||.|. .  | . .. ..    ||  .|. .| ||.. .|||.|.  .|.  |
tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2366-2435 6e-11 36.9 In-house 209-279 (307) alignment
Range on Protein: 2366-2435
Range on HMM: 209-279/307.0
PAPLLVHCSAGVGRSGVVVLSDVIANKTRKGY-IPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVLE
  |..||||||||||| .|   .. .|  .|    |.. .|  .||||. .|||  |.  |.   |.  ||
tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfle

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2367-2433 8.1e-14 45.6 In-house 210-276 (515) alignment
Range on Protein: 2367-2433
Range on HMM: 210-276/515.0
APLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKV
 ||..|||||||| |||.  | .  . ... . ||  .| ..| .||  .|| ||....|.  | ..
hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2367-2434 3.6e-13 44.3 In-house 218-285 (297) alignment
Range on Protein: 2367-2434
Range on HMM: 218-285/297.0
APLLVHCSAGVGRSGVVV-LSDVIANKTRKGYIpDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVL
.||||||.||||| ||.. . .|.|.  |.  . |.  .|. .| .||  .|| ||....|   |. .|
gPllvhclaGvGrtgvlltidsvvaeakrekev.difglvkklrqerpylvqtkeqykfvyvavleall

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2367-2434 1.4e-12 41.7 In-house 169-237 (392) alignment
Range on Protein: 2367-2434
Range on HMM: 169-237/392.0
A-PLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVL
. ||..||||||||.|||.  | .  ...|  . ||  .|. .| .||. .|| ||....|   |. .|
thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledll

subfamily_CG42327_pd Subfamily CG42327 2367-2428 2.1e-10 34.8 In-house 248-310 (319) alignment
Range on Protein: 2367-2428
Range on HMM: 248-310/319.0
APLLVHCSAGVGRSGVVVLSDVIANKTRKG-YIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDF
 || |||| ||||.|.|. ||.  ..  .     |.  .|| || .|  ...| ||. ..|  
GPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2367-2432 1.7e-09 31.6 In-house 213-278 (439) alignment
Range on Protein: 2367-2432
Range on HMM: 213-278/439.0
APLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKK
 |..|||||||||.| ..  |.  .. .     |.. .|...| ||   .|.| |. ..|.  |. 
gpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavled

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2367-2425 7.7e-09 29.9 In-house 193-251 (267) alignment
Range on Protein: 2367-2425
Range on HMM: 193-251/267.0
APLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLL
 ||.|.||.||||||  .  |   .....  . |.  ..  .||||.  ..|.|..  .
rPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyi

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2367-2430 1.2e-07 26.0 In-house 205-268 (288) alignment
Range on Protein: 2367-2430
Range on HMM: 205-268/288.0
APLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFAL
 |..||.||||||.| ..|. ....  |      .|....  | .|  .|||  |.  ..   |
kPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvl

subfamily_PTPN1_pd Subfamily PTPN1 2367-2427 1.2e-07 25.7 In-house 202-265 (290) alignment
Range on Protein: 2367-2427
Range on HMM: 202-265/290.0
APLLVHCSAGVGRSGVVVLSDVIANKT---RKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYD
 | ..|||||.|||| ..| | .  .     .    |.. ..  .|..|   ||| .|. . | 
GpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsyl

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2368-2435 1.6e-06 22.1 In-house 211-274 (312) alignment
Range on Protein: 2368-2435
Range on HMM: 211-274/312.0
PLLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTllydFALKKVLE
|.. ||||||||.| ..| . .    |.    .|. .  ..| .|  ..... |.     .||. |||
pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyv....yalrcvle

subfamily_PTPDC1_pd Subfamily PTPDC1 2369-2429 4.2e-07 24.6 In-house 117-172 (182) alignment
Range on Protein: 2369-2429
Range on HMM: 117-172/182.0
LLVHCSAGVGRSGVVVLSDVIANKTRkgyipDVRTMVSIVRSQRPMTIQTLEQFTLLYDFA
. ||| || || ||.. . .. .|       .    ...|||.|| .||| ||  |. .||
vavhChaGlGrtGvliacylvyakrl.....taekaiklvrskrpksiqtreqvelvkefa

PTEN_1 2369-2429 4.8e-07 24.8 In-house 133-189 (196) alignment
Range on Protein: 2369-2429
Range on HMM: 133-189/196.0
LLVHCSAGVGRSGVVVLSDVIANKTrkgyiPDVRTMVSIVRSQR-PMTIQTLEQFTLLYDFA
 |||| ||.||||.|| .  .. .       ...  ...||..| |. ... .|  ||. ||
VlVHCkaGlgRsGtvvaayLmykgk.....ltadeAlelvrekRppgapnspsqerlleyfa

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2369-2438 9.6e-06 19.3 In-house 224-293 (302) alignment
Range on Protein: 2369-2438
Range on HMM: 224-293/302.0
LLVHCSAGVGRSGVVVLSDVIANKTRKGYIPDVRTMVSIVRSQRPMTIQTLEQFTLLYDFALKKVLEVEG
.||||||||||.| .|      .   |  . |. ..|  ||. |  ..|. .| . |  .  | ..| .|
vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglmekag