Gene MbrePTP-Un-11 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP052_AA protein Get Run
MbreP052_AA_4066-4301 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
EGF EGF-like domain 9-40 2.5e-07 18.1 Pfam-A 1-31 (32) alignment
Range on Protein: 9-40
Range on HMM: 1-31/32.0
CDRLgqPCQNGATCNDQT-DGYSCSCAFGYTGA
|.    ||.||.||.|   .||.| |. |||| 
Cspn..pCsngGtCvdtpgggytCeCpeGytGk

EGF EGF-like domain 49-79 2.8e-09 24.4 Pfam-A 1-31 (32) alignment
Range on Protein: 49-79
Range on HMM: 1-31/32.0
CASNPCVNGGTCSQSAAGSYECSCSTGWTGD
|..||| ||||| ..  |.|.| |  |.||.
CspnpCsngGtCvdtpgggytCeCpeGytGk

EGF_2 EGF-like domain 49-81 2e-06 14.5 Pfam-A 1-32 (32) alignment
Range on Protein: 49-81
Range on HMM: 1-32/32.0
CASN--PCVNGGTCSQSaagSYECSCSTGWTGDDC
| ..   | ..||| ..      |.|. |..|..|
CsadgliCgghGtCvkq...cgkCvCdsgyqGktC

EGF_CA Calcium-binding EGF domain 84-124 4.8e-06 13.1 Pfam-A 1-42 (42) alignment
Range on Protein: 84-124
Range on HMM: 1-42/42.0
DIDECASAP--CKNGGSCSQpVVGAFACACTAGYSGPTCESEC
|.||||| .  |.....|.   .| | | | .||.  . |..|
DvdECasgthnCpentvCvN.teGsfeCvCeegyennedetkC

EGF EGF-like domain 88-119 4.8e-08 20.4 Pfam-A 1-32 (32) alignment
Range on Protein: 88-119
Range on HMM: 1-32/32.0
CASAPCKNGGSCSQPVVGAFACACTAGYSGPT
|.. ||.||| | .   | . | |. ||.|..
CspnpCsngGtCvdtpgggytCeCpeGytGkr

EGF_2 EGF-like domain 88-120 8.3e-06 12.5 Pfam-A 1-32 (32) alignment
Range on Protein: 88-120
Range on HMM: 1-32/32.0
CAS--APCKNGGSCSQPvvgafA--CACTAGYSGPTC
| .  . | ..|.| ..        | |..||.|.||
CsadgliCgghGtCvkq.....cgkCvCdsgyqGktC

EGF EGF-like domain 1116-1144 1.3e-06 15.8 Pfam-A 1-30 (32) alignment
Range on Protein: 1116-1144
Range on HMM: 1-30/32.0
CLDCPCEQGAPCTQSG-NGYQCECPAGYTG
| . ||  |. |.... .||.|||| ||||
CspnpCsngGtCvdtpgggytCeCpeGytG

hEGF Human growth factor-like EGF 1135-1147 1.8e-06 16.7 Pfam-A 1-13 (13) alignment
Range on Protein: 1135-1147
Range on HMM: 1-13/13.0
QCECPAGYTGVNC
.|.||.|||| ||
tCqCppGyTGpnC

EGF_CA Calcium-binding EGF domain 1150-1181 2.7e-06 13.9 Pfam-A 1-34 (42) alignment
Range on Protein: 1150-1181
Range on HMM: 1-34/42.0
DINECADVP--CSFGSTCVNLVANYSCVCWAGLS
|..|||. .  |. ...||| .  ..||| .| .
DvdECasgthnCpentvCvNteGsfeCvCeegye

EGF EGF-like domain 1207-1229 5.7e-08 20.2 Pfam-A 4-30 (32) alignment
Range on Protein: 1207-1229
Range on HMM: 4-30/32.0
DPCMNGGSCQPSG----SCSCAMGYTG
.||.||| |....    .| |..||||
npCsngGtCvdtpgggytCeCpeGytG

EGF_CA Calcium-binding EGF domain 1235-1266 1.3e-08 21.3 Pfam-A 1-34 (42) alignment
Range on Protein: 1235-1266
Range on HMM: 1-34/42.0
DIDECADEP--CLNGGQCEDGIGSYSCTCAEGFE
|.||||...  | ....|.  .||..|.| ||.|
DvdECasgthnCpentvCvNteGsfeCvCeegye

EGF EGF-like domain 1239-1268 1.3e-10 28.6 Pfam-A 1-31 (32) alignment
Range on Protein: 1239-1268
Range on HMM: 1-31/32.0
CADEPCLNGGQCEDGI-GSYSCTCAEGFEGD
|...||.|||.| |.  |.|.|.|.||. |.
CspnpCsngGtCvdtpgggytCeCpeGytGk

EGF EGF-like domain 1277-1306 1.2e-08 22.4 Pfam-A 1-31 (32) alignment
Range on Protein: 1277-1306
Range on HMM: 1-31/32.0
CENNNCAMGSTCVDGI-NSYTCACVPGYTGI
|  |.|  | ||||.  ..||| | .||||.
CspnpCsngGtCvdtpgggytCeCpeGytGk

EGF EGF-like domain 1315-1344 1.2e-09 25.6 Pfam-A 1-31 (32) alignment
Range on Protein: 1315-1344
Range on HMM: 1-31/32.0
CEPVPCHNGATCTEGI-NTFTCTCASGFGGS
| | ||.||.||...  ...||.|..|. | 
CspnpCsngGtCvdtpgggytCeCpeGytGk

EGF_2 EGF-like domain 1722-1747 4.1e-08 19.8 Pfam-A 7-32 (32) alignment
Range on Protein: 1722-1747
Range on HMM: 7-32/32.0
PCQNGGTCLTSSGLCQCTDSYTGSAC
 |...||| .. | |.|...|.|  |
iCgghGtCvkqcgkCvCdsgyqGktC

EGF EGF-like domain 3698-3725 2.4e-06 15.0 Pfam-A 1-29 (32) alignment
Range on Protein: 3698-3725
Range on HMM: 1-29/32.0
CALDPCLSGGSCIKEF-FDYRCVCAPGYL
|. .||. || |.     .|.| |..|| 
CspnpCsngGtCvdtpgggytCeCpeGyt

EGF EGF-like domain 3738-3766 2.9e-09 24.3 Pfam-A 3-32 (32) alignment
Range on Protein: 3738-3766
Range on HMM: 3-32/32.0
GHDCQNGATCVDGV-DGYYCACAPGFDGET
 . |.||.||||.  .||.| |..|..|..
pnpCsngGtCvdtpgggytCeCpeGytGkr

EGF EGF-like domain 3774-3803 5.2e-08 20.3 Pfam-A 1-31 (32) alignment
Range on Protein: 3774-3803
Range on HMM: 1-31/32.0
CTESACAHGGTCVDEV-HGYSCECPTGYRGD
|..  | .||||||   .||.|||| || |.
CspnpCsngGtCvdtpgggytCeCpeGytGk

EGF_2 EGF-like domain 3774-3805 3.2e-06 13.8 Pfam-A 1-32 (32) alignment
Range on Protein: 3774-3805
Range on HMM: 1-32/32.0
CTES--ACAHGGTCVDEvhGYSCECPTGYRGDFC
| ..   | ..||||..     |.|. || |. |
CsadgliCgghGtCvkq..cgkCvCdsgyqGktC

EGF EGF-like domain 3898-3924 7.9e-09 22.9 Pfam-A 4-31 (32) alignment
Range on Protein: 3898-3924
Range on HMM: 4-31/32.0
TPCLHGGTCLDKV-NGFACTCPTTYFGD
.||..||||.|   .|. |.||  | |.
npCsngGtCvdtpgggytCeCpeGytGk

EGF_2 EGF-like domain 3935-3960 6e-06 12.9 Pfam-A 7-32 (32) alignment
Range on Protein: 3935-3960
Range on HMM: 7-32/32.0
PCRNGGTPNRTTARCECTSGFEGRFC
 | ..|| .... .|.|.||. |  |
iCgghGtCvkqcgkCvCdsgyqGktC

subfamily_egg_pd Subfamily egg 4066-4298 7.7e-20 65.8 In-house 65-268 (307) alignment
Range on Protein: 4066-4298
Range on HMM: 65-268/307.0
EYANddtlvhlqdeqnSYINANHVTfaeeGRTL--WYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGgkVKCERYWPTETGEYDALVFGDLKISL
 |..             .| ||.|     |. |   .| || ||  || ||||||...  | .||.|  .|    .|| |||    .   .| | |.|  
qyld............dfihanrvk....Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrien

VKSVSS--GNYTIRGLRVrNMSEDLMRTVWHLQYTaWPDHSVPKTPSSLLdfideiREIRvrlmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRLE
.|  |     ...  |..   ..|  | . | |.  .   |   .|  .|      | .|         |   |.||..  || ....|. .|  |. | 
lkvdskadplfrvtklkl.vGgddeerflehwqgd.vnnssdvysplrvl......rklr.........nlskpvvvqdilGvskaatlvaieiallsll

QGM--RPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLE
.|   .   ... | || .|   |..  .| |  | .| 
rGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf

0050432 (Phosphotyrosine protein) phosphatases II 4067-4304 1.1e-77 256.8 In-house 78-303 (308) alignment
Range on Protein: 4067-4304
Range on HMM: 78-303/308.0
YANDDTLVHLqDEQNSYINANHVTFAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEyDALVFGDLKISLVKS
...| . |.| || ..||||..|..   ...  .||.|||||.||.|||||||||.....||.| .|| |..||..|||.|.|. . |..|.... |.. 
lpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgg.gsleygkftvtllse

VSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRvrlmgvavnnPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRP
 . ..||.| |...|.... .|||.|..||.||||.||  |..||||....|. .          |. |.||||||||||||.. ...  | .||.. ..
evlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..........pggpivVHCsaGvGRtGtfialdllleqlekeggv

NPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKRQ
.. ...  |||||. .|||.|||.|. |.||| .....
dvfeavkklReqRpgmvqtpeqylflyralleylklkl

0036941 (Phosphotyrosine protein) phosphatases II 4067-4304 3.2e-74 245.2 In-house 49-281 (297) alignment
Range on Protein: 4067-4304
Range on HMM: 49-281/297.0
YANDDTLVHLQDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDAlvFGDLKISLVKS
...|.| |.|.|| ..||||..|.. . .|.  .||.|||||.||.|||||||||.....||.| .|| |..||..|||.|.||.    .||... |.. 
lpydhtRVklddegsdYinAsyvdgydlkrk..fIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegeslt..ygdftvtllsv

VS--SGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRvrlmgvAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLE---
 .  ...||.| |.| .. ..  |||.|..|| ||||.|| .|.||||||...|...      .  ... |..|||||||||.|.. ...  | .||   
evvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl......kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledkl

QGMRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKRQ
   .... ... .|||||. .|||.|||.|. ..|||  .|. 
keggvdileavkklReqRpgavqtleqyrflyeallellkkkl

0040438 (Phosphotyrosine protein) phosphatases II 4067-4303 7.2e-74 244.2 In-house 53-279 (317) alignment
Range on Protein: 4067-4303
Range on HMM: 53-279/317.0
YANDDTLVHLQDEQ----NSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTetgeYDALVFGDLKIS
. .|.. |.|....    ..||||..|.. ...|.  .||.|||||.||.||||||||||....||.| ..| |..||..|||.     . |..||... 
lpydhsRVkLsplggdldsdYInAsyvdgpnlkrk..fIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl....getltygdftvt

LVKSVSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRvrlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQ
|.. .  ...|.| |.| .. ..  |||.|..||.||||.||..|..||||....|| .        ..|. |..|||||||||||.. ...  | .||.
llseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal........edpggpvlVHCsaGvgRtGtfiaaylmleqlek

GMRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKR
...... ... ||||||...|||.|||.|. . |||  ...
eggvdveeavkelreqRpgavqtpeqyrflydalleylkrk

0046845 (Phosphotyrosine protein) phosphatases II 4067-4303 7.2e-73 240.7 In-house 38-277 (284) alignment
Range on Protein: 4067-4303
Range on HMM: 38-277/284.0
YANDDTLVHLQD-----EQNSYINANHVTFAEE---GRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgeYDALVFGD
...|.. |.|.      | ..||||..|.. .     ..  .||.|||||.||.|||||||||.....||.|..|| |..||..|||.|    . |..||
lpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple...gevltygd

LKISLVKSVSSGNYTIRGLRVRNMS-EDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESEL
... |..    ..||.| |...|.. ..  |||.|..||.||||.|| .|..||.|....||.. .      .... |.||||||||||||.. ...  |
ftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen......lpgggpivVHCsaGvgRtGtfialdlll

IRLEQGM---RPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKR
 .||..    .... ...  |||||   |||.|||.|. ..||| ....
eqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk

0047943 (Phosphotyrosine protein) phosphatases II 4067-4298 9.3e-72 237.1 In-house 48-270 (273) alignment
Range on Protein: 4067-4298
Range on HMM: 48-270/273.0
YANDDTLVHLQDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEyDALVFGDLKISLVKS
...|.. |.|.|. ..||||..|.. . .|.  .||.|||||.||.|||||||||.....||.| .|| |..||..|||.| ||   |..|.... |.. 
lpydhsrvklgdggsdyinAsyvdgynlkrk..fiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwplegge.lsltygkftvtllse

VSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGVavnnppWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRP
 . ..||.| |...|.. .  |||.|..|| ||||.|| ...|||.||...|...  |..        |.||||||||||||.. ...  | .|| . ..
etkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn......gpvvVHCsaGvgRtgtfialdllldqlekeggv

NPRQTLVELREQRAKVVQTEEQYEFCLRTLLE
.. ...  ||.||  .|||.|||.|. ..|||
dvleavkllrsqRpgmvqtpeqyrflyealle

0039614 (Phosphotyrosine protein) phosphatases II 4067-4302 4.7e-70 231.7 In-house 66-291 (297) alignment
Range on Protein: 4067-4302
Range on HMM: 66-291/297.0
YANDDTLVHLQDEQN-----SYINANHVTFAEE-GRtlWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKvKCERYWPTETGeydalVFGDLK
...|.. |.|..| .     .||||..|.. .  .|   .||.|||||.||.||||||||||....||.| .|| |. ||..|||.|.|     ..||..
lpydhsrvklkpedgvdldsdYinAsyvdgydlltr..kfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.....tygdft

ISLVKSVSSGNYTIRGLRVRNmsEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRL
. |.|    ..||.| |.|.|  ..  |||.|.||| ||||.|| ....||.|....||.. .|      ... |..|||||||||||.. .    | .|
vtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealael......pkggpvlVHCsaGvgRtGtfiaaylmleql

EQGMRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVARK
| . .... ... |||||| ..|||..||.|. . |||  ..
ekeggvdvleavkelreqRpgavqtpsqyrflydallellkr

0045450 (Phosphotyrosine protein) phosphatases II 4067-4299 6.3e-69 228.4 In-house 65-303 (307) alignment
Range on Protein: 4067-4299
Range on HMM: 65-303/307.0
YANDDTLVHLQD-----EQNSYINANHVTF------AEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgeYDALV
...|.| |.|..     | ..||||..|..          ... .||.|||||.|| |||||.||||....||.|..|| |..|| .|||.|    . |.
lpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde...geelt

FGDLKISLVKSVSSGNYTIRGLRVRNM-SEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvavNNPPWPTVVHCSAGVGRTGVLMLVE
.|.... |..    ..||.| |.| ..  ..  |||.|..||.||||.||.....|||||.|.|... .      .... |..|||||||||||....  
ygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkalee......lpkggpvlVHCsaGvgRtGtfiaay

SELIRLEQGMR---PNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEV
  | .||..     ....... .||||| ..||..|||.|. . ||| 
lmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

0045098 (Phosphotyrosine protein) phosphatases II 4067-4301 1e-63 210.7 In-house 43-273 (278) alignment
Range on Protein: 4067-4301
Range on HMM: 43-273/278.0
YANDDTLVHlqdeqnSYINANHVTFAeegrTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPtEtgeYDALVFGDLKISLVKS
...| . |.       ||||.....     .  .||.||||| || |||||.||.|....||.|..||.|..||..||| |    . |..||... |.. 
lpydhsrVk......dYINAsyidgy....pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.e...ggsltygdftvtllse

VSSGNYTIRGLRVRNM----SEDLMRTVWHLQYTAWPDHSVPKTP--SSLLDFIDEIREIRVRLMGVAV-----NNPPWPTVVHCSAGVGRTGVLMLVES
   ..||.| |.|.|     ...  |.|.||.|. ||||.|| .|  .|.|.....||| . .|... .     .... |..|||||||||||.| ..  
evlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaayl

ELIRLeqGMRPNPRQTLVELREQRAK-VVQTEEQYEFCLRTLLEVAR
 | .|  . . .. ... |||.||   .||..|||.|. . |||. .
mlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

0037934 (Phosphotyrosine protein) phosphatases II 4067-4298 1.5e-63 209.9 In-house 20-240 (243) alignment
Range on Protein: 4067-4298
Range on HMM: 20-240/243.0
YANDDTLVHLQDeqNSYINANHVTFAEegRtlwYIAAQGPLPGTVGD----FWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPtetGEYdalVFGDLKIS
...|.. |.|..  ..|||||...  .  |   .|| |||||.|| |    ||||.||.|....||.| .|| |..||..|||   ||.   ..||... 
lpydhsrvkleg..sdyinanliyvtp..r...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gev...tygdftvt

LVKSVSSGNYTIRGLRVRNMS-EDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGVAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLe
|... . ..||.| |...| . .|| |.|.|..|..||||.|| .|..||||.||.||.  .|. . ....  |..|||||||||||.| .    | .| 
llseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll.

qgmRPNPRQTLVELREQRAK-VVQTEEQYEFCLRTLLE
   . .. ... .|||||   .|||..||.|. . |||
...gvdleeavkllreqRpgkavqtpsqyrflyealle

0051299 (Phosphotyrosine protein) phosphatases II 4068-4300 2.8e-73 242.2 In-house 60-286 (288) alignment
Range on Protein: 4068-4300
Range on HMM: 60-286/288.0
ANDDTLVHLQD----EQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTetgeYDALVFGDLKISL
..|.. |.|..    | ..||||..... . .|.  .||.|||||.||.|||||||||.....||.|..|| |..||..|||.     . |..||... |
pydhsRVkLsvldgvegsdYinAsyidgynlkrk..fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl....ggsltygditvtl

VKSVSSGNYTIRGLRVRNM----SEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVrlmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIR
.. .. ..||.| |.|.|.     ..  |||.|..||.||||.|| .|..||||. ..|. .         ... |.||||||||||||.. ...  | .
lseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala........sgggpvvVHCsaGvgRtgtfialdllleq

LEQGMRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVA
||.. .... ...  |||||  .|||.|||.|. ..||| .
lekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0043336 (Phosphotyrosine protein) phosphatases II 4068-4298 1.1e-68 227.0 In-house 56-275 (278) alignment
Range on Protein: 4068-4298
Range on HMM: 56-275/278.0
ANDDTLVHLQDEQ----NSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPtetgeYDALVFGDLKISL
..| ..|.|....    ..||||..|.. . .|.  .||.|||||.||.||||||||.|....||.|..|| |.||| .|||      . |..||... |
pydhsrvklsllggdldsdYinAsyvdgynvprk..fiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.....ggsltygdftvtl

VKSVSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRvrlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQG
.|  . ..||.| |.| |. ..  |||.|..|..||||.|| ..|.||||. ..||..        .... |..|||||||||||......  | .|| .
lkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal........edsngpvlVHCsaGvgRTGtfialyllleqleke

MRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLE
 .... ... ||||||.. |||..||.|. . |||
ggvdleeavkelreqRpgavqtpsqyrflyealle

DSPc_SM00195 4068-4300 5.1e-67 221.3 In-house 37-262 (263) alignment
Range on Protein: 4068-4300
Range on HMM: 37-262/263.0
ANDDTLVHLQDEQ----NSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETgeYDALVFGDLKISL
 .|.| |.|..|.    ..|||||....|.. ..  |||.||||| || ||||||||....|.||.| |.| || ||.|||| |    .  .||.... |
pydhtrVklkkeekkegsdYINAnyikgankkkk..yIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees..ggketfgkisvkl

VKSVSSG-NYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLmgvavnnpPWPTVVHCSAGVGRTGVLMLVESELIRLEQ
|.  .   ....| |....  ..  |.| ..||..||||.||....|.|... .... . .           |.||||||||||||....... | .||.
vevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts........sgpivVhCsaGvgRtgtfvtidiilsklee

GMRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVA
. ...  ... |||.||...|||.||| |. ...||..
ekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 4068-4300 5.1e-67 221.3 In-house 37-262 (263) alignment
Range on Protein: 4068-4300
Range on HMM: 37-262/263.0
ANDDTLVHLQDEQ----NSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETgeYDALVFGDLKISL
 .|.| |.|..|.    ..|||||....|.. ..  |||.||||| || ||||||||....|.||.| |.| || ||.|||| |    .  .||.... |
pydhtrVklkkeekkegsdYINAnyikgankkkk..yIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees..ggketfgkisvkl

VKSVSSG-NYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLmgvavnnpPWPTVVHCSAGVGRTGVLMLVESELIRLEQ
|.  .   ....| |....  ..  |.| ..||..||||.||....|.|... .... . .           |.||||||||||||....... | .||.
vevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts........sgpivVhCsaGvgRtgtfvtidiilsklee

GMRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVA
. ...  ... |||.||...|||.||| |. ...||..
ekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

0042113 (Phosphotyrosine protein) phosphatases II 4068-4298 1.3e-65 216.5 In-house 20-241 (245) alignment
Range on Protein: 4068-4298
Range on HMM: 20-241/245.0
ANDDTLVHLQDEQ----NSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTetgeYDALVFGDLKISL
..|.|.|.|....    ..||||..|.. .  ..  .||.|||||.||.|||||.||.|....||.| |.| |.|||..|||.     . |..||... |
pydhtrvklspdggdldsdyinasyvdgyritpk..fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl....gesltygdftvtl

VKSVSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQG
..  . ..||.| |.| |. .|  |.|.|..|. ||||.|| ....||||....|... .       ... |..|||||||||||.....   | .||  
lseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.......dsngpvlVHCsaGvgRtGtfiaaylmleqleke

MRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLE
.. .. ... |||.|| ..|||..||.|. . |||
lgvsleeavkelrsqRpgavqtpsqyrflyealle

0040439 (Phosphotyrosine protein) phosphatases II 4068-4299 7e-65 214.4 In-house 22-245 (249) alignment
Range on Protein: 4068-4299
Range on HMM: 22-245/249.0
ANDDTLVHLQD----EQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTetgeYDALVFGDLKISL
..| . |.|..    . ..||||.....   .|.  .||.|||||.||.|||||.||.|....||.| .|| |..||..|||.     . |..||... |
pydhsrvklsilpglflsdyinAsyidgyyikrr..fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl....ggsleygdftvtl

VKSVSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQG
..  ....||.| |.. |. ..  |||.|.||| ||||.||.....|||||...|... .|      ... |..|||||||||||.. .    | .||  
lsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel......pkggpvlVHCsaGvgRtGtfiaaylmleqleke

MRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEV
 . .. ... .||.|| ..||..|||.|... ||| 
lgvdleeavkllrsqRpgavqnpeqyrflyeallel

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 4068-4297 1.2e-46 153.9 In-house 44-292 (297) alignment
Range on Protein: 4068-4297
Range on HMM: 44-292/297.0
ANDDTLVHLQD--EQNSYINANHVTFAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLVK
| ||| |.|.    .. ||||..|.| .|   | || |||||  || |||..|.||. ...|||.   |.|. ||  |||   .|   |  ||. .  . 
atddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe..rlkagdvvvefls

SVSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDF-----------------IDEI-REIRVRLMGVAVNNP-PWPTVVHCSAGVGR
|.|    ..    .. .  .  | | | |. .|||| ||     |  |                 .. .   . ..|  .  . | . ...|||||||||
stsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGr

TGVLMLVESELIRLEQGMRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLL
.||..| .  | .| ..  |. .  |  ||||||..||| ||.|..    |
sGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 4068-4301 1.1e-35 117.7 In-house 67-284 (290) alignment
Range on Protein: 4068-4301
Range on HMM: 67-284/290.0
ANDDTLVHLQDEQ-NSYINANHVtfaeEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLVKS
 || | | |.| .   |. ||.|    .|    .| .||.|  || |.|||| ...   .||.   .| || |||.|.| . ||  .| ||.. .   ..
cndktrvilkdGydGdyvhanyv....kGlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGe..vltfGeitvlcsee

VSSGNYTI-RGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIrvrlmgvavnnpPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMR
 .  . .| . | ||.. .     . ||.  .|||.||...  .||  .  .|..            . | |||||||.|||| .. .|  |  | .|  
ddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka............sGpvvvhcsaGiGrtGtfvaievglqilldGke

PNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVAR
 .. ..   ||. |.. || . ||   .. ||.. .
ldlldlvralrnsrlnsvqvdiqylalveilldlGk

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 4068-4301 6e-34 112.2 In-house 44-267 (283) alignment
Range on Protein: 4068-4301
Range on HMM: 44-267/283.0
ANDDTLVHLQDEQNSYINANHVTFA-EEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEyDalvFGDLKISLVKS
. |   |.|. | ..|||| ... . .. .   ||.||.||  || |||.||...    .||.|   |. ..|| .||| .  | |   .|.. ..| | 
padqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGse.d...yGeftvtlrke

VSSGNYTIRGLRVRNM---SEDLMrtVWHLQYTAWpdhsVPKTPSSLLDFIDEIREIrvrlMGVAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQG
..|  ..|. | .|.     . |.  . | |.  |    .   . . .. .  .  .    .    ...  | |||||.|.|||.|.. . . .  .   
ttsnsfiikelllrvnssakstll..lahyqvidW....leygeqaiinslvkfnkv....islqteskkgPivvhCstgiGrtavfiaasasvkdalte

MRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVAR
   .  ...  .||||  .||| .|| .     || | 
svvdvfavvkimreqrmmavqtldqyklvhelvleqal

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 4068-4299 9.9e-32 104.8 In-house 66-288 (305) alignment
Range on Protein: 4068-4299
Range on HMM: 66-288/305.0
ANDDTLVHLQDE-QNSYINANHVTFAEEGrTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDALVFGDL--KISLV
..| ..|.|..     || ||.|          .|.|||||  |. .|| || ..  . .||.   || ||.|| .|||.  ||   |  | .  ..|  
cqdqsavkldkpspsdyihanyvgcpmip.ekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgs

KSVSS-GNYTIRGLRVRNmSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVrlmgvavnnppwPTVVHCSAGVGRTGVLMLVESELIRLEQG
| .    .  |  |..   | |   .| |||.| |||  ||    . |...  ||  .|            | |||||||.|||| .. .|  | .. . 
kpmerdaeiqitllnlty.sgdqkmsvrhlqwtewpdrgvppckltslellsairgskv............pivvhcsagigrtgtivaieyilekiaen

MRPNPRQTLV-ELREQRAKVVQTEEQYEFCLRTLLEV
 .  |   ||  ||.|||  .|.. || |  | .|. 
kpcppmpelvkalrdqrafsiqndvqylfihrvmlny

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 4068-4299 8.8e-28 92.1 In-house 54-270 (288) alignment
Range on Protein: 4068-4299
Range on HMM: 54-270/288.0
ANDDTLVHLQDEQNSYINANHVTFAEEGRTLwyIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLVKSV
  | | |.|.|. . ||.|| |. |.  | |  | || || ||.. .|.|. |.. . .||..  .| || | . |.|.. ||  .  .| |     |. 
rcditrvklsddpdfyiaanvvssakykrrl..icaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGe..karigrlctvvkkkr

SSGNYTIRGLRVRNMSEDLMRT-VWHLQYTAWPDHSVPKTPSSLLDFIDEIreirvrlmgvavNNPPWPTVVHCSAGVGRTGVLM--LVESELIRLEQGM
.  . ...   .|.  |   .  | .| .  |.|..||.   | | ... .            ..   | |||.|||||||| |.  |.  | .||.  .
adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl............kslqkPivvhssaGvGrtgtlililialeslrlddfl

rpNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEV
    |. | .|||.| | .||| || .  | .|| 
..girsllaklreerfkaiqtemqylyvhrcvlee

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 4068-4307 2.6e-19 63.8 In-house 62-292 (302) alignment
Range on Protein: 4068-4307
Range on HMM: 62-292/302.0
ANDDTLVHLQDEQNSYINANHVTFAEEGRTLwyIAAQGPLPGTV---GDFWRMVWEQGSQIVVMVTGEVEGGKvKCERYWPTETGEYDAlvFGDLKISLV
. |..|| |. |..||.|| .|.  | .|..  | || |  ...    .|||||...  . ||.. || |  |   . ..|...|.|    .|.. .   
ildsnlvkleaepdsyvnaskvevPeltrsi..ilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdyke..ygkmfvNnr

KsVSSG-----NYTIRGLrVRNMSEDLMRTVWHLQYtaWPDHSVPktpSSLLDFIDEIREIrvRLMGVAVNNppwPTVVHCSAGVGRTGVLMLVESELIR
| |..      .|.|  |   ..|. .. .| .|..  |....||    .  . | .. ..      . ...   .||.    |.|| |... .   . .
k.VekaeeektryviEvl.Pegcsnsvlanvyvltn..Wkqkkvp...vkyaeliktaakv..fakkikade...ntvivSknGaGRagafltlavavek

LEQGMRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKRQTAE
|..|  ||  ...  .|.||...|.. .|| .  ..||   .|. | .
lqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkp

subfamily_PTPN3_pd Subfamily PTPN3 4069-4301 7.8e-69 226.7 In-house 53-276 (280) alignment
Range on Protein: 4069-4301
Range on HMM: 53-276/280.0
NDDTLVHLQDEQNSYINANHVTFAEEGRTLW--YIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETgeyDALVFGDLKISLVKS
 |.| |.|..... |||||.| .  .. .|   |||.||||. |. |||.||||| |...||.|  || |.||| .|||...   | | .|.... . |.
ydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPete...deleygefsvkceke

VSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRvrlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRP
 .. .| .| | ... ...  |.. .|||.|||||.||. ....|.|....|..|        .    |.|||||||.||||||.|.|  |  .|.    
detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr........sgkeePvvvhCsaGigrtGvlilletalalieaaepv

NPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVAR
.| . . ..|.||| .|||..||.|   ..|.| .
ypldivrtmrdqramlvqtasqykfvCeailkvye

Y_phosphatase Protein-tyrosine phosphatase 4069-4298 9.4e-66 216.9 Pfam-A 13-235 (235) alignment
Range on Protein: 4069-4298
Range on HMM: 13-235/235.0
NDDTLVHL--QDEQNSYINANHVTFAEEgrTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLV-K
 |.| |.|  ..... |||||.|.  .|  .  .||.||||. |..|||||||.. ....||.| ..| |..||..|||.|..|   | .||.|. |. |
ydktrvklkgsegpsdYInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee..sltygdikvelkek

SV-SSGNYTIRGLRVRNMSED-LMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRvrlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQG
.   . .||.| |....  |.   |.|..|.||.||||.||..|.||||.|..... .        ..   |.||||||||||||......  | .||..
ekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk........eaksgpvvVhCsaGvgRtgtfvaldilleqleae

MRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLE
  ..  |.. |||.||...||..|||.|. ...||
eevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 4069-4298 9.4e-66 216.9 In-house 13-235 (235) alignment
Range on Protein: 4069-4298
Range on HMM: 13-235/235.0
NDDTLVHL--QDEQNSYINANHVTFAEEgrTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLV-K
 |.| |.|  ..... |||||.|.  .|  .  .||.||||. |..|||||||.. ....||.| ..| |..||..|||.|..|   | .||.|. |. |
ydktrvklkgsegpsdYInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee..sltygdikvelkek

SV-SSGNYTIRGLRVRNMSED-LMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRvrlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQG
.   . .||.| |....  |.   |.|..|.||.||||.||..|.||||.|..... .        ..   |.||||||||||||......  | .||..
ekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk........eaksgpvvVhCsaGvgRtgtfvaldilleqleae

MRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLE
  ..  |.. |||.||...||..|||.|. ...||
eevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_PTPN23_pd Subfamily PTPN23 4069-4303 6.2e-57 187.6 In-house 55-283 (288) alignment
Range on Protein: 4069-4303
Range on HMM: 55-283/288.0
NDDTLVHLQDEQNSYINANHVTFAEEGrTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLVKSVS
 | . |.|..... |||| .|     | .  .||.|.||..|..|||.||.|| |...||.. . | || |..||||...||  . .||||...| .  .
yDhnRvklrgskDDYinAsfvkdlspg.cPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkge..tvkfgdlsvtlksvre

SGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGV--AvnnppwPTVVHCSAGVGRTGVLMLVESELIRLEQGM-R
....  | |...  ..| ...| |||.|.||.. ||..|..||.|.||...          .      | |||||||||||||. || . .. ||.|   
tethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt......PlvvhCsaGvgRtgvfalvyaavrelekgngl

PNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKR
..  | .  |||||  .||..||..|..   || ||. 
ldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrv

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 4069-4299 1.7e-38 127.2 In-house 59-277 (287) alignment
Range on Protein: 4069-4299
Range on HMM: 59-277/287.0
NDDTLVHLQDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGeydaLVFGDLKISLVKSVS
 |.  | |..|.. |||| ..   .| .   .|.|..|.  |. .||......  ...||.. | |  . .| .|||.|.     .|.|. .|.|..   
pdnyrvllkgehpdyinavfidgykekka..fiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks....vvlGeyniellneev

SGNYTIRGLRVRNMS-EDLMRTVWHLQYTAWPDHS-VPKTPSSLLDFIDEIREIRVRLMGvavnnppwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRP
. .|..| |.|.| . ..  ..|   |.|.|...  |..  ..|| . . ... | |  .        . |||||..|||..... ..  . . ..    
nagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgnt........sivvhCsdtvGrsamfcaaattinkckteGvi

NPRQTLVELREQRAKVVQTEEQYEFCLRTLLEV
.  | | . | |. . ||| |||.|    .|| 
Dvfqvlksqriqkpgsvqtveqykfindivley

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 4069-4303 3.3e-25 83.6 In-house 45-262 (267) alignment
Range on Protein: 4069-4303
Range on HMM: 45-262/267.0
NDDTLVHLQDEQNSYINANHVTFAEEGRtlWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGgkvKCERYWPTETGEydALVFGDLKISLVKSVS
 ||| | |..... |||| .|   . ..  ..|. |.||  |..||. .. .|.  ..|..|   ..   .  ..|| . |.  |  . || .       
yddtrvilrtkeeeyinasyvegyktkn..afivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPPkmgq..akkyqdltvehsleke

SGNYTIRGLRVRNMSEDlMRTVWHLQYTAWPDHSVPKtPsslldFIDEIREIrvrLMGVAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNP
  .| |  | ..   |   . |    |  |   .  | |     ..  .  |   |    ..|   | ||.||.||||.| .. ..| | |. .    . 
endyqiitlelkfknes.ahnvtlyyykkwnintnnk.p.....ylkplfgi...laknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdi

RQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKR
 . | ..|.||  .|.| |.| .. ..| | |. |
fdflrkirsqriglvdtkeryiyihellaeyaegr

subfamily_eak_pd Subfamily eak 4069-4304 2e-18 60.9 In-house 66-309 (332) alignment
Range on Protein: 4069-4304
Range on HMM: 66-309/332.0
NDDTLVHLQDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGeyDALVFGDLKISLVKSVS
.   |   | ... ||||  . |.| ||   || .  .    |  ||.|| || |  .|..  .|| .  | ..|.| .|   . | || |..   . | 
ylvrltssqlnrlGyinaslaefsevGrk..yiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktr..eelkfGildverkefvk

SGNYTIRGLRVRNMSEdlMRTVWHLQYTAWPDHSVPKTpSSLLDFIDEIREIRVRLMGVAVNN-------------PPWPTVVHCSAGVGRTGVLMLVEs
 ...  | | ..   |     | | ..  | . ..||    .| . . ..|. | |. |  ..             |    .. .. |  |.||..... 
rniletrllelskGne..thrvlhykvfGwtettlpky.edflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsaraGvfvvid.

ELIRLEQGMRPNP---RQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKRQ
 |||| .. . |     . ..  ...| . | .. |. |    .|.  ..|.
llirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn

subfamily_PTPN13_pd Subfamily PTPN13 4070-4300 2.3e-65 215.6 In-house 50-269 (273) alignment
Range on Protein: 4070-4300
Range on HMM: 50-269/273.0
DDTLVHLQDEQNsYINANHVTFAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEyDALVFGDLKISLVKSVSS
|.| |.|.|| . ||||...    .  .  |||.||||| || |||.||||| .....||| |.|.|||||.|||| ....    | . |...|.| .  
detrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknk.klkvsnrlevellkvqkl

GNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMgvavnnppwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPR
 ....| | |...     | | ||....||||.||... .|| |. |.|...             | |||||||.||.|.|. ..  |  .|.    . .
dgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdag.........PivvhcsaGiGrsGtlitidvvlglierdkefdvk

QTLVELREQRAKVVQTEEQYEFCLRTLLEVA
... .|||||  ||||..|| |. ...||| 
eivrklreqrqgvvqtkdqyifvykailevl

subfamily_PTPN6_pd Subfamily PTPN6 4070-4305 2.5e-62 205.6 In-house 67-302 (306) alignment
Range on Protein: 4070-4305
Range on HMM: 67-302/306.0
DDTLVHLQDE---QNSYINANHVTFAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDalvFGDLKISLVKS
|.| | |...   .. ||||| .. . .| .  |||.|| |. || |||||||.. |...||.| ||| || || ||||.|. . .   .|..... |..
DhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee...yGkisvtnvse

VSSGNYTIRGLRVR-NMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLE-QG-
 |  .|..| |.|  . ...  |.|.......||||.||| |. .|||...... . .|.    .. . |.|||||||.|||| .....  |  .| .| 
ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeele....eaeagpivvhCsaGiGRtGtfiviDillkliekkgl

-MRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKRQT
 .  . ...   .||||  .||||.|| |  ... .  .....
dadidiqklvksvreqrsglvqteqqykfvykaikkyietkkk

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 4070-4302 7.1e-58 190.9 In-house 54-278 (281) alignment
Range on Protein: 4070-4302
Range on HMM: 54-278/281.0
DDTLVHL----QDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGeydALVFGDLKISLVK
| | |..    ..... |||||.|   .. .   |||.|||.| .. .||.|||||  ...|||| |.|.||.|| |||| ..    .| .||.... ..
DatrvkvtpneenkntDYinanfvpgykgeke..yiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddns...elkygdvtvksta

SVSSGNYTIRGLRVrNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGvavnnppWPTVVHCSAGVGRTGVLMLVESELIRLEQG-M
. .. .|  | ... ....   |.| .|.||||||| ||.|.. ||.| .|..... .           | |.||||||||||. . ..  . ..|.   
eeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk.......aplvihCsaGvGrtGtyialDrlvkaveaele

RPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVARK
. ...... |||..|  .|||  ||||  ...|..  |
eldvkavvaelrkernlmvqtvvqyefvykavldaldk

subfamily_PTPN1_pd Subfamily PTPN1 4070-4301 1.3e-56 186.5 In-house 45-272 (290) alignment
Range on Protein: 4070-4301
Range on HMM: 45-272/290.0
DDTLVHLQDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGeYDALVFG--DLKISLVKSV
| . ..|....| ||||. | . |  |   || .||||| ||. ||.||||| |. |||.   || ...|| .|||..    ..|..    ||. |..  
dhsrikleradndyinaslveleeakrs..yiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee.ekellledtklkvklisee

SSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREirvrlMGVaVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMR--
.. .||.| |.. |.. .  |.. |  ||.||| .||..|...|.|. ..||      |. ...   |.|.|||||.||.| ..||.. |...|.     
rksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvre.....sGs.lssdvGpavihcsaGiGrsGtfclvdtclvliekkddls

-PNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVAR
  . ...|.|||..|  ..|| .| .|   ..|| |.
svdikkvllelrkyrlGliqtadqlrfsylaileGak

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 4070-4307 3.4e-55 182.1 In-house 60-286 (288) alignment
Range on Protein: 4070-4307
Range on HMM: 60-286/288.0
DDTLVHLQD----EQNSYINANHVtfAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETgeyDALVFGDLKISLVK
| . |.|..    ... ||||...  ..|...  |||.||||. ||.|||..|.|. .. .||.|. ||||| |||.|||..    .   .|.... ||.
DekrvklkkleeeagaDYinasyi..dgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdad...kpknyGsvtvtlve

SVSSGNYTIRGLRVRnmSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLmgvavnnpPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMR
|   .... | | .    .   ... ..||.|||||.||.    ||.... .                 | .|||||||||||. . ..  . ..|.   
skeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad........tgpiivhCsaGvGrtgtFialdalidaveeedy

PNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKRQTAE
 .   |. .||.||| .|||..||||. ..||... ..  ||
iDvagtvaklRkqRallvqtlkqYefiyevllslieedgvae

subfamily_PTPRN_pd Subfamily PTPRN 4070-4297 5e-44 145.2 In-house 69-289 (297) alignment
Range on Protein: 4070-4297
Range on HMM: 69-289/297.0
DDTLVHLQ----DEQNSYINANHVTfAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydalVFGDLKISLVK
|.. |.|.    .|.. ||||  ..  .. |.  |||.||||. || |||.||||||. ..|..|   | |  .|.|||| |  |    |..  .. || 
dhsrvklkeeasaeksdyinasail.dhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGse....vyhiyevhlvs

-SVSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIdeiREIRVRLMGVAVnnppwPTVVHCSAGVGRTGVLMLVESELIRLEQGM
  . . .| .| . ..|.  .  |||  . . .||...|| .. |||.|    | .     | .      | |||||.|.||||| .|..  | || .|.
ehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefr...rkvnksyrGrsc.....pivvhcsdGaGrtGvyilidlvlnrllkGv

RPN-PRQTLVELREQRAKVVQTEEQYEFCLRTLL
.      ||  ||.||...|.|..|.||.| .. 
keidiaatlehlrdqrpglvktkdqfefaltava

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 4070-4296 1.1e-42 140.9 In-house 51-273 (287) alignment
Range on Protein: 4070-4296
Range on HMM: 51-273/287.0
DDT---LVHLQDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgEYDALVFGDLKISLVKS
|||   |..  .   .|||||.|.  ..  .  .||||||.. ||.||||.|.|. |  |...| ||| .. || .|||    |   .| |   . | ..
ddtrvllsaegelGsdyinanyvasytddea..fiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer..evPmrvGGysvvlldyd

VSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEI-REIRVRLMGVAVNnppwPTVVHCSAGVGRTGVLMLVESELIRLEQGMR
. . .|..| ||. ..     | |  |.. .|||.... |  .|. |. .. . | ..  .  |     | |||...|.||.|.|. .   . |||.  |
ikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevG....PlvvhddvGiGrsGillatlvlvsrledlGr

PNPRQTLVELREQRAKVVQTEEQYEFCLRTL
 .. .... |||.|| .||.  |. .   .|
vdvaavvirlreyraalvqavvqlrllyeal

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 4070-4298 5.1e-23 76.4 In-house 48-268 (285) alignment
Range on Protein: 4070-4298
Range on HMM: 48-268/285.0
DDTLVHLQDEQNSYINANHVTFAEEGRTlWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLVKS--V
..| | |.. .  || |. . .  . ..  ||..||||| |. |||.|....    |.|.   .|||  ||  |.| . ||   . ||  .|.| .    
eetrvvlknhdrdyihaswmrmpgkdqs.tyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge..vvkfgkyeitlteckee

SSGNYTIRGLRVRNMSEDLMRT--VWHLQYTAWPDHSVPKTPSSLLDFIDEIREirvrlmgvaVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMR
.     .  | | |  .       . |.|   |||.  |.    ....   ...         ||    | .||||||||||  .. ..   ||. .   
aiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.........vnpkekpicvhcsagvgrtatfvgidyatirimenpn

PNPRQTLVELREQRAKVVQTEEQYEFCLRTLLE
 .  . . |.|  | . ||.  |. |    |.|
iemldivremramrfqavqshmqflflyvvlme

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 4070-4293 1e-13 45.6 In-house 60-272 (303) alignment
Range on Protein: 4070-4293
Range on HMM: 60-272/303.0
DDTLVHLQDeqNSYINANHVTFAEEGRTlwyIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgeYDALVFGDLKISL--VKSV
| . |.| |   ||| |... .  . ..   | .| ||. |  |||.|. ||  . |...  . |  |.  .  .| .    | | | .  | .   | |
dhskvklsd..ssyihasyleldsskka...iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn...qdflkfeersirvgefkrv

SSGNytIRGLRVRNMSEDLMRTVWHL-QYTAWPDHSVPKTPSSllDFIDEIREIRVRLMGVAvnnPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGM-R
  |.     |.|  .|.   ..  |. .| |||  |.|   |.   |. .| ...  |   .   .  |||    .|.||.| . | |.  . | .    
elgd..gwvlkvlsvsngdyksflhvhhykawphnsipsdgsp..kfvkqiwqlqsvlrkys...dstptvymslsgcgragtfalfetahlslhseqas

PNPRQTLVELREQRAKVVQTEEQYEFCL
 .  . |  .|. | . ||   |. .  
ldlvkclenvrngrlhavqnlsqfsvvy

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 4072-4299 1.7e-32 107.6 In-house 58-276 (307) alignment
Range on Protein: 4072-4299
Range on HMM: 58-276/307.0
TLVHLQDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDALVFGDLKISL----VKSV
 .|...     || ||..  | . .   .|.|||||  |. .|| |. ..  . |.|.   .| .|.|||.||| | |.  . .     ||.    .| .
ivvkfdglasdyihanylgiaikpkk..ficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakkl

SSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDeireirvrlmgvAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPN
.  .  |    ..    .  ||. |||.. |||. ||..  . .....            ||.    | ||||||||||.| .. .     .. .|.   
apdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlle............avrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinck

PRQTLV-ELREQRAKVVQTEEQYEFCLRTLLEV
  . || |||.||   .||| || .  | ||| 
dmkklveelrsqrhyaiqteaqylylhrvlley

subfamily_PTPN14_pd Subfamily PTPN14 4073-4298 1.2e-64 213.2 In-house 68-294 (300) alignment
Range on Protein: 4073-4298
Range on HMM: 68-294/300.0
LVHLQDEQNSYINANHVTFAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDALVFGDLKISLVKSVSSGNY
|.  ..... |||| ..  .  |... ||.|||||. || |||.|||||| |..||.| | |.|| |. .|.| .. . . . ||  |..   | .|. .
lsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsv

TIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGVA-VNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQT
. .||... .     ||||||||| |||| ||. ... |....|.. .| .       ..   | .|||||||||||||.|..  .  ||.. . . ...
ittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkv

LVELREQRAKVVQTEEQYEFCLRTLLE
|  |||||  .|||  ||.|  ..|..
larLreqrmllvqtlaqYkfvYkvlik

subfamily_PTPRB_pd Subfamily PTPRB 4073-4306 6.9e-63 207.4 In-house 67-291 (293) alignment
Range on Protein: 4073-4306
Range on HMM: 67-291/293.0
LVHL----QDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgeYDALVFGDLKISLVKSVS
 |.|    ..... |||||..   .  |   .||.|||||.|| ||||||||. |.|.||.|  ||.||||||.|||..   ... ..||.|..||.. .
rvkLaalkdesgsDYinanyipgynspre..fiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad...eepvlyGdikvtlvaeee

SGNYTIRGLRVRNmsEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNP
  ...|| |....  |. .|.| ....|.|||| ||.....||||. ..||   .      ..   |.||||||||||||... ..  | ..|.    . 
ledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiek......taskrPivvhCsaGvGRtGtfialdrllqaieeedyvdi

RQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKRQTA
  ...||||.|. .||||.|| |  ...|.. ||....
fgivaelReeRnllvqtekqYifihqcvldllrkkeee

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 4073-4302 6.3e-62 204.5 In-house 62-282 (318) alignment
Range on Protein: 4073-4302
Range on HMM: 62-282/318.0
LVHLQ----DEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgeyDALVFGDLKISLVKSVS
 |.||    .|.  |||||..   .. ..  |||||.||| |. |||||||||.|...||.| |.| ||.|..|||| .    ..  .|.|.. | ..|.
rvkLqmlegeegsDyinanyidGyrrkka..yiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk....gsrsygklvvelkeeve

SGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNP
...|..| ..|..  |.  |.|   .||.|||..||. ..||||.. .....  .       .   |.||||||||||||| . |.. | |...    . 
lsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqk.......sgagpivvhCsaGvGrtGvfiavdillerikaealvDv

RQTLVELREQRAKVVQTEEQYEFCLRTLLEVARK
 ||  .|||||  .||||.||||.  .|||    
fqtvkqlreqrnlmvqtedqyefiydvllealas

subfamily_PTPRK_pd Subfamily PTPRK 4073-4301 9e-48 157.7 In-house 62-278 (314) alignment
Range on Protein: 4073-4301
Range on HMM: 62-278/314.0
LVHLQDE-QNSYINANHVtfAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYdalvfGDLKISLVKSVSSGN
|. .... .. ||||. .      |.  .|..||||. || ||||.|.....  .||.|  || |.||| .||| .|  |     ||.|. ||..    .
litidgdpssdyinaali..dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevy.....gdikvelvetellae

YTIRGLRVRN--MSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvavnnPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPR
. .| .||..   . . .|.| ..|...|||| ||.   .||... .. . .             ..||||||| ||||. . ... |  .|.    .  
lvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee........eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvf

QTLVELREQRAKVVQTEEQYEFCLRTLLEVAR
..  .||...  .|.||||| |.   .|| . 
navktlrsrkvnmveteeqykfiydvileacl

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 4073-4300 2.5e-41 136.9 In-house 67-288 (325) alignment
Range on Protein: 4073-4300
Range on HMM: 67-288/325.0
LVHLQD-EQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMV--WEqgsQIVVMVTGEVEGGKVKCERYWPTETGeyDALVFGDLKISLVKSVSS
|. ..|  .  ||||...    .  .  ..||| ||. |..|.||.|  |.     ||.|. |...|| .|  ||| | |  ..  || |...|.     
letkkddpssdyinasylrddkkkdv..flaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavywpkemg..ksktfGglevklrtieei

GNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGVavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPR
 .|  | | |.....   |.|  .|. .|.|  |.| |..|. ... . ..  |.      .   | .||||||||||||.. . | | .. .  | .  
sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtan..tkastpilvhcsaGvGrtGvfislysalakvieesrvdif

QTLVELREQRAKVVQTEEQYEFCLRTLLEVA
. .  ||..| ..|.| .|| ..  .| |. 
gfvkklrkdrpsmvetvdqyiliyealveay

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 4073-4293 5.7e-13 43.0 In-house 53-281 (302) alignment
Range on Protein: 4073-4293
Range on HMM: 53-281/302.0
LVHLQDEQNSYINANHVTFAEegrtLWYIAAQGPLPG-----------------TVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALV
. .|.| .| .|||| ... |    . .| ||||. |                 |.  .| .. .    ||| ... ||... ||  |. .. |.   | 
maklvdfkndfinanvlklde....ikwimaqGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvgg..elk

FG-------DLKISLVKSVSSGNYTIRGLRVRNM--SEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLmgvavnnppwptVVHCSAGVGR
||       ..|  | .     ....  . ..|    ... .||  |...|||||  || . . || .      .  .            .|||||||||
fgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesykknv............lvhcsaGvGr

TGVLMLVESELIRLEQGMRPNPRQTLVELREQRAKVVQTEEQYEFCL
|| |. .   .    .    .  . .. .|. |   ||.|.|  . |
tGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 4074-4300 3.6e-27 89.9 In-house 60-276 (312) alignment
Range on Protein: 4074-4300
Range on HMM: 60-276/312.0
VHLQDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEY---DALVFGDLKISL-VKSVSS
  |  ..| || || |          ....||||  |.  ||...   ||  .....| || |  || .|     |     |  |. .    . .   | 
ftlagdenfyihanfvkictkper..fvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggksk

GNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPktpssllDFIDeireIRVRLMgVAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPR
 . | | |.|   .      . | |...|||| .|       |  |       ||.  ||..   | . |||||||||| |.|.|| .  | .  . | .
dkithrvlkvvvkatgqesklnhyqwaswpdhgmp.......dscd....talrll.savkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvk

QTLVELREQRAKVVQTEEQYEFCLRTLLEVA
...| || .||. |..  || ..||..||. 
dsfvllrkdrarsvrvfpqyvyalrcvlefl

subfamily_ptpA1_pd Subfamily ptpA1 4075-4251 5.5e-32 106.0 In-house 68-247 (418) alignment
Range on Protein: 4075-4251
Range on HMM: 68-247/418.0
HLQDE-QNSYINANHVTFAEEGRtlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEY-------DALVFGDLKISLVKS
..||.  . |||||..  |   .   .|..||||| |. ||||||||.  .|.||.. | |  ..||.|||| . |            |||   . ||. 
kiqdkegsdyinanyidgaypkq...fictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelvev

VSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGVAVNNppWPTVVHCSAGVGRTGVLM
.   .  |    .|   |   | . . ||  |||| .|     . ...  | . . ...  .  |   | .||||||||||| . 
iqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrn..vpiivhcsagvgrtgtfc

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 4075-4292 2e-30 100.5 In-house 64-285 (301) alignment
Range on Protein: 4075-4292
Range on HMM: 64-285/301.0
HLQDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDAlvFGDLKISLVKSVSSGNYTI
.|.  |..||||...    | .   .||||||.  |. ||||..|..  . .||||.. || | |||.|||. . | .   || ... ||..    ...|
nldlcqreyinasyidgysekkk..fiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaesee..fgpftvtlvneqvyPdfvi

RGLRVR--NM-------------SEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGVavnnppwPTVVHCSAGVGRTGVLMLVEselIR
| | |.  .              |.   ..|  || | ||.. | . |   |  ||..   . .  |        | |||||..|.|.|| . |.   | 
rqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkiggg.......pvvVHCSdtVsrsGvYcsvs...ig

LEQGMRP---NPRQTLVELREQRAKVVQTEEQYEFC
|||  .    .  |    .| .. ..|.| ||| . 
lEQckaegVVdvfqvtkavrrskpgaVtTLeqytsi

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 4076-4302 3.5e-55 182.0 In-house 52-270 (274) alignment
Range on Protein: 4076-4302
Range on HMM: 52-270/274.0
LQDEQNSYINANHVTFAEeGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDALVFGDLKISLVKSVSSGNYTIR
 .||. ||||||..   . ...  |.|.||||| || |||||.... .|..||.|   |  . ||..|.|....   .  .||..|  .| |.  .|..|
sededssyinanyikGyd.eeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvr

GLRVRNMSEdlMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvaVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVEL
 | ......   |.| |  ||.|||| .|. ...|||...|..| | .      |..  |.|||||||.||||. . ..  . .|.. .  .  .. ..|
klvlkyler..ersvkhywytdWPdhksPddantlldlvleveesree.....enaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnl

REQRAKVVQTEEQYEFCLRTLLEVARK
| .|  .|||.||||.  |.| . ...
rldrGGmvqtseqyelihralclylkr

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 4076-4299 1e-52 174.2 In-house 67-282 (305) alignment
Range on Protein: 4076-4299
Range on HMM: 67-282/305.0
LQ--DEQNSYINANHVTFAEegRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDAlvFGDLKISLVKSVSSGNYT
 .  .... ||||..|   .  |   ||.|||||. || ||||...|   . .||.|. ||||| ||..|||....|     ||.... |  . .  .|.
ekeslddsdyinasyvdgyk..rkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekke..fgefsvelksektasdyi

IRGLRVRN-MSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGVAVnnppwptVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTL
.| |.. .  ...  ||| ..| | |||| ||....|||..|..... . .  ||..       .|||||||||||| . |.  | ||..    .  . |
eRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpl.......lVhCsagvgRtGvfiavdialerlkkEevvdvfevl

VELREQRAKVVQTEEQYEFCLRTLLEV
 .||..| |.||| .|| |.   | | 
kqlRskrmkmvqtldqYvflhdaldel

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 4076-4302 2e-41 137.0 In-house 73-286 (297) alignment
Range on Protein: 4076-4302
Range on HMM: 73-286/297.0
LQDE-QNSYINANHVTFAEEgrtlWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKvKCERYWPTETGEYdalvFGDLKISLVKSVSSGNYTI
..|. .  |.|| .|   ..     .|. | | . || |||.||...  ...||.. . |. | || |||. ..       |||. . |    .   .  
vnddpdsDyvnasfvkgnkh....rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt....fGdvsvvllsvsereGfik

RGLRVRNMSEDLMRTVWHLQYTAWPDHSVPK--TPSSLLDFIDEIREIRvrlMGvaVNNPpwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTL
| | |.. .    | |   |.. |||..|..  . ||||..|.|.|.      .  ...   | .|||.|||||||||. ..| . . ..    .  ...
relevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdf...sq..naeg..PllvhclaGvGrtgvlltidsvvaeakrekevdifglv

VELREQRAKVVQTEEQYEFCLRTLLEVARK
  ||..| ..|||.|||.|   ..||.   
kklrqerpylvqtkeqykfvyvavlealls

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 4076-4301 9.3e-41 134.6 In-house 65-284 (290) alignment
Range on Protein: 4076-4301
Range on HMM: 65-284/290.0
L------QDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgEYDAlvFGDLKISLVKSVSS
|      .| .|.|||| ..   .| .   |||.|||.. |. |||...|.. . |.||.| ..| |||||  |||..  . .|  .|  .| |..  . 
LrpisghkDCtneyinAcyikgykekkq..yiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtka..ygefsikllneetl

GNYTIRGLRVRNMSE-DLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlMGvavNNppwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNP
 .|..| |.|.|... .  ..| ..| |.|...   . |.. |  | |. ... .  |   |.   . |||||..|||..|.. ..  . . ..    . 
neyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrk.rg...nt...sivvHCSdtvgrsavfcaaattinkcktegvidv

RQTLVELREQRAKVVQTEEQYEFCLRTLLEVAR
 | | ..| |. . |||..||..  . .|.   
fqvlksqRiqkpgsvqtvqqyqgifqivltyld

subfamily_CG7180_pd Subfamily CG7180 4076-4299 3.9e-33 109.3 In-house 64-289 (296) alignment
Range on Protein: 4076-4299
Range on HMM: 64-289/296.0
LQD-EQNSYINANHVTFAEegRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKvKCERYWPTETgeydALVFGDLKISLVKSVSSGNYTI
|.  |.. |||| .|      .   ||  ..|   ||..|||.|...... ||..| . .  | ..  ||| ..       .|.. . .|.. .  | .|
ldGeeksdYinavyvdsfl..kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks....keqygeifveiveekqyanlki

RGLRVRNM----------SEDLMRTVWHLQYTAWPD-HSVPKTPSSLLDFIDEIREIRVRLmgvAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQG
| ...  .           .   |.| ..|.| |.  ..||   ..|....  .| .| .      ..   |.||..| |..|.|| . ..  |  .|. 
rtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv...dedpeegPvvvvssdGasRsGvylaidanlelveke

MRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEV
 . .  . .  ||..| ..|.. |.| ..  .||| 
eevdvFeavktlrrsRpqLvenveeYkyiYdvllea

subfamily_CG42327_pd Subfamily CG42327 4076-4219 6e-28 92.4 In-house 51-192 (319) alignment
Range on Protein: 4076-4219
Range on HMM: 51-192/319.0
LQDEQNSYINANHVTFAEEGRTlWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDALVFGDLKISLVKSVSSGNYTIR
 .|... |..|..|   .. ..  ||||| .|  .  ||||.|||| |...| .|   | |  .| .|.||. .  .  ..||....| .  .  .| | 
gdddkdeyldasyvrGyddapn.syiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryais

GLRVRNMSEDLMRTVWHLQYtAWPDHSVPKTPSSLLDFIDEIRE
 | .... ... | . |  |  |..  ||  ...|.  . |.|.
tlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 4076-4289 8.4e-28 92.0 In-house 70-270 (301) alignment
Range on Protein: 4076-4289
Range on HMM: 70-270/301.0
LQDEQNSYINANHVTFAeeGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDALVFGDLKISLVKSVSSGNYTIR
..| .   | || .     |..  .||.||||. |  ||| |.     . .||.. .||  . ||| | |....|   .   ..||   ... . . . |
ivdGkrvPihanwipts..GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskr

GLRVRNMSEDL-MRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREirvrlmgvavnnPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVE
 |.|.. ....  ||| | ||. |.|. |||.   | |... ...               | |||||||.||.  ..  |    ..|   . .  ..| .
tlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk............sekPivvhcsaGiGrsvafigteylareveadptieltealkh

LREQRAKVVQTEEQY
|||.| . |||..| 
lrehrwngvqtnsql

subfamily_PTPRD_pd Subfamily PTPRD 4077-4304 1.1e-69 230.6 In-house 72-285 (564) alignment
Range on Protein: 4077-4304
Range on HMM: 72-285/564.0
QDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtGeydALVFGDLKISLVKSVSSGNYTIRG
.||.  ||||...   .. ..  |||.||||. |. ||||||||| |...||.|  .| |||||..|||.. |      .|.|...|....   .|.|| 
gdegsDYINAsfidgyrkrka..yIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g...tetygeltVtleeeeeladyeirt

LRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRvRlmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELR
..... ... .|.| . ..|.|||| ||... ||||.|...|... .       .   |.||||||||||||. . ... | |...    . .|.. .||
fklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e.......pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalr

EQRAKVVQTEEQYEFCLRTLLEVARKRQ
.||  .||||||| |. ...||   . .
kqRnamVqteeQYiFiheailealacgn

subfamily_PTPN9_pd Subfamily PTPN9 4077-4303 5.7e-62 204.4 In-house 66-293 (297) alignment
Range on Protein: 4077-4303
Range on HMM: 66-293/297.0
QDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLVKSVSSGNYTIRG
.||.  |||||.|   .. ..  .||.||||. || |||||||||   ..||.|  || |..|| .|||.|...  .  ||||..| |. ... .|..| 
edeasdyinanfvdGykqkka..fiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees..saefgdlsvsnveveeeedykvrv

LRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIR---VRLMGVAVNNPP--WPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQT
| ..|. .. .|.| | |...|||. ||.. .||||.....|| .   |. .|   . .|   | |||||||.|||| .. ..  | |||.    . ..|
leiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvet

LVELREQRAKVVQTEEQYEFCLRTLLEVARKR
.  ||.|||  .||.||||||  ..|| | ..
vkllrtqrafsiqtpeqyefcylavleyalel

subfamily_PTPN12_pd Subfamily PTPN12 4077-4303 8.4e-59 193.8 In-house 64-280 (290) alignment
Range on Protein: 4077-4303
Range on HMM: 64-280/290.0
QDEQNSYINANHVTFAEEgrTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLVKSVSSG-NYTIR
..|...|||||..  .|.  .| ||||||||| |. |||||.||.  .||||.  ||| || ||||||| |..|  .| ||.....| .      ...||
eeegsdYinanfikgveg..kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegee..elefgefevtleeekavdddflir

GLRVRNMSEdlMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVrlmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNP---RQTL
 |.|.. .|   |.|  ..||||||| ||....|||..|...||..         .   | ||||||||||||... ..     |.... |.     . .
tLkveaqke..srkvyqfhYtaWPDhgvPssaksllelielvrelqe........sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlv

VELREQRAKVVQTEEQYEFCLRTLLEVARKR
.|||.||| .|||.||||.  ....|. .|.
lelrkqraalvqtkeqyelvykavaelvqke

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 4077-4304 1.2e-56 186.7 In-house 44-268 (270) alignment
Range on Protein: 4077-4304
Range on HMM: 44-268/270.0
QDEQNSYINANHVTFA-EEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDALVFGDLKISLVKSVSSGNYTIR
.|..  |||||.|  . .| ..  ||||.|||| |. .||||.||. .. .||.|| .| |. |||||||.|..|  .| .|..|.  .... .  | ..
edsataYinAnyvrGfdgekkk..YiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyilt

GLRVRNMSEDlMRTVwHLQYTAWPDHSVPKTPSSLL---DFIDEIREIRvrLMGVAVNNPPwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTL
 ||... .|   | | | .|..||||.||... | |   . .  .|..|   .    ..   |..|||||||||||.|....  .  ||. .. .. . .
rlrleekgee.rrlv.HfwyntWpdhgvpreedsslstdqllkmlravr..rsekeldkae.PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaii

VELREQRAKVVQTEEQYEFCLRTLLEVARKRQ
 |||..| ..||. |||||  ....| |..|.
eelRkdRmalvqhpeqyeflykavveyaerra

subfamily_Ptp69D_pd Subfamily Ptp69D 4077-4307 6.5e-55 181.4 In-house 72-293 (307) alignment
Range on Protein: 4077-4307
Range on HMM: 72-293/307.0
QDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgeyDALVFGDLKISLVKSVSSGNYTIRG
 .|. .||||...   .| ..  .||||.|. .|.||||||..|| ....||.. . |  . ||..||| |    |   .||. . ||.. . ..|.|| 
gkedsdYinasfikgykekkk..fiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie....devqygdilvklvseekhsdyiiRe

LRVRNMS-----EDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLmgvavnnpPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQT
| | ..      ..  | |   .||.|.|  ||... .||..|...||.              | ||||||||||.|... ..| | .|..  . .  .|
ldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln........rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifet

LVELREQRAKVVQTEEQYEFCLRTLLEVARKRQTAE
  .||.||  .||  |||.|. | ||.   . .| |
vkdLrsqRnllvqsleqYvflyralldyssygdtde

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 4077-4299 5e-52 172.0 In-house 80-289 (298) alignment
Range on Protein: 4077-4299
Range on HMM: 80-289/298.0
QDEQNSYINANHVTfAEEGRTlWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydalVFGDLKISLVKSVSSGNYTIRG
.||.  |||| ..  | .||.  .||.|.||. || ||||||.|. .. .||.|  .| .|.|...|||.|  |     .|....|| .. . .....| 
adeesdYiNAsflh.aykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke....tygeitvsllskeefadlivrk

LRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREiRVRLMGvavNNppwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELR
| | . .|.  |.| .|..| |||..||.. .|.||.....|    .  |   |.   | .|.|||||||.|  . ..| | |...      .|..  ||
lkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqag...nk...pvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlR

EQRAKVVQTEEQYEFCLRTLLEV
..|...||||||| |.    ||.
kkrpgavqteeqYvfiyeavlea

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 4077-4303 4.5e-51 168.8 In-house 71-286 (319) alignment
Range on Protein: 4077-4303
Range on HMM: 71-286/319.0
QD-EQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETgeydALVFGDLKISLVKSVSSGNYTIR
.. |.  ||||...   .| .   .||.|.||  |. ||||||||..| ||||.|. || .|||...|||.|.      ..| | . | .     .| ||
dgvegsdyinasfidgyqerek..fiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeen....feeyGrlivtleeeeeledyiir

GLRVRNMSEDL-MRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVE
 | ... |...  |.| | |||.|||| ||..  ||||.. .||. | .       .   | ||||||||||||  . ..  | |...    .  .|  .
klklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrek.......tqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsr

LREQRAKVVQTEEQYEFCLRTLLEVARKR
|| ||  .||..|||.|.  .|||..   
lRtqRnimvqrpeqYkfiyealleaveag

subfamily_PTPRG_pd Subfamily PTPRG 4077-4306 1.9e-48 160.1 In-house 72-293 (563) alignment
Range on Protein: 4077-4306
Range on HMM: 72-293/563.0
QDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydalVFGDLKISLVKSVSSGNYTIRG
....  |||||..   . ..   .||.||||. |. |||||.||| ..|.||.|  || |. ||..|||... |     .| |.. |...     ||.| 
kkkklDYinAnyidGyqkska..fiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdese....tygalqvtlieeevlalytvrt

LRVRN-----MSE-DLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIreirvrlmGVAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQ
| ..|      .. |  ..| . .|| ||||.||. .   | |.             | ..   |.||||||||||||... ... | ...|    |  .
lviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks........saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfg

TLVELREQRAKVVQTEEQYEFCLRTLLEVARKRQTA
.|  .| ||  .||||||| |   .|||. . ..| 
flkhiraqRnflvqteEqYiflhdalleaiaskete

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 4077-4299 2.7e-48 159.3 In-house 33-241 (250) alignment
Range on Protein: 4077-4299
Range on HMM: 33-241/250.0
QDEQNSYINANHVTFAEEGrtLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVkCERYWPTETGEydalVFGDLKISLVKSVSSGNYTIRG
 |..  |||| ..   .|     .||.||||. |. ||||||.|. |. .||.|  .| .|. ...|||.|. |     .||...|| ..   ..||.| 
gdkesdyinasflhgyder..kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae....kyGdvtvsllskeefadytkrk

LRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvaVNNPpwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELR
| . . ..   |.| .|....||| .||..  . |.......  . .     ..|   | .|.|||||||.|  . ... | ||..    . .. .  ||
lklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq.....agna..PvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlr

EQRAKVVQTEEQYEFCLRTLLEV
..| ..|...||| |. . .|. 
kdrphavesleqyvfvyeiilka

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 4077-4305 1.4e-46 153.8 In-house 68-282 (315) alignment
Range on Protein: 4077-4305
Range on HMM: 68-282/315.0
QDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGeyDALVFGDLKISLVKSVSSGNYTIRG
.. .. |||| ..   .. ..  |||.||||. .| ||||||...    .||||   || |.|| .||| . .  |.  || .|..|..  . .. ..| 
dsPdsdyinasyiksvdddka..yiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrka..dsvefGsikvellsleadtdgvark

LRVRNMSEdlMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIReirvrlmgVAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELR
| .|.  |   |||   |.| |||. |.|  |||| .| |..           ..  .. .||||||||||||.. ... . .....   .  ... .||
lvtrksee..srtvtqfqftewPdkGvdkqtssllklikevk........adngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlr

EQRAKVVQTEEQYEFCLRTLLEVARKRQT
..| ..|||||.| |   ..||    |.|
akrpylvqteeeyafiydavledllwrnt

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 4077-4299 8e-46 151.4 In-house 73-278 (315) alignment
Range on Protein: 4077-4299
Range on HMM: 73-278/315.0
QDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgeydALVFGDLKISLVKSVSSGNYTIRG
.|..  |.||| .   .  |   |||||||.. .|.||||.|.|.    .||.|. ||| | |.|.||| .      ...| . .....     .||.| 
ndphsdyvnanfidGynkkrr..yiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.....kviyGkitvtrkseevnteytvrt

LrvRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMgvavnnppWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELR
|    ...| .|.|  |.||.|||  |||   .|...|  ..  .   .         . |||||||||||| .. ... | ..|     .  . .  .|
l..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv........gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvr

EQRAKVVQTEEQYEFCLRTLLEV
..| |.||. |||.|   .||| 
qnrikmvqvaeqyqfiydallet

0046846 (Phosphotyrosine protein) phosphatases II 4077-4298 2.9e-37 123.5 In-house 8-171 (176) alignment
Range on Protein: 4077-4298
Range on HMM: 8-171/176.0
QDEQNSYINANHVTFAeegrtlWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDalvfgdlkislvksvssgnytirg
 |.  .||||| .  .      ..|| |||||.|. ||..|..|.| ..||..| ||| |..|| .||| ....                          
ldldldyinanlilgs......rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

lrvrnmsedlmrtvwHLQYTAWPDHSVPKTpSSLLDFIDEIREIRvrlmgvavN-NppWPTVVHCSAGVGRTGVLMLVEseLIRLeqGMRPNPRQTLVEL
               . ... ||||.||   . ||.....||| .        . .   |..||||||.||||.| .    |..|  ..  .. ..| ..
...............qylhlpwpDhgvpdl.elllellefireal........keg..gpvlVHCsaGigRtgtlvaay..llel..ekglsveealalv

REQRA-KVVQTEEQYEFCLRTLLE
||||  ..|||.|||.|. . .|.
reqRplgavqtpeQyrflyefell

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 4078-4298 4e-42 139.6 In-house 86-289 (319) alignment
Range on Protein: 4078-4298
Range on HMM: 86-289/319.0
DEQNSYINANHVTFAEegRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTgeveggKVKCERYWPTETGEYDAlvFGDLKISLVKSvsSGNYTIRGL
 |   |||| .||     |   ||||||||. |. |||||.||. .  .|..|      | || .||| .. . .    ...|...|.   . .|..| .
eefsdyinasfvtGyq..rkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikee..rfkvkvdsvee..taeyvvrdi

RVRN-MSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELR
.. .   |  .| .    .  |||. ||. || |. ... .| .. .      .| . . ||||||||||||| . ..  | |...  . .  ... .||
elsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsk......enhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlr

EQRAKVVQTEEQYEFCLRTLLE
.|| ..||   || |.  .|||
qqrntlvqdlvqykfiysalle

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 4078-4298 8.3e-42 138.6 In-house 50-253 (284) alignment
Range on Protein: 4078-4298
Range on HMM: 50-253/284.0
DEQNSYINANHVTFAEegRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTgeveggKVKCERYWPTETGEYDAlvFGDLKISLVKSvsSGNYTIRGL
 |   |||| ..|     |   |||.||||. |. |||||.||. .  .|..|      | || .||| .. . .    ...|...|.   | .|..| .
eefsdyinasfitGyq..rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikee..rfkvkvdsvee..seeyvvrdi

RVRN-MSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELR
.. .   |  .|..    .  |||. ||. || |. ... .| .. .      .| . . ||||||||||||| . ..  | |...  . .  ... .||
elsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltsk......enhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlr

EQRAKVVQTEEQYEFCLRTLLE
.|| ..||   || |.  .|||
qqrntlvqdlvqykfiysalle

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 4078-4298 9.2e-41 134.6 In-house 26-237 (237) alignment
Range on Protein: 4078-4298
Range on HMM: 26-237/237.0
DEQNSYINANHVTfAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTeTGeyDALVFGDLKISLVKSVSSGNYTIRGL
  .  ||||...    .|    ||||||||  .  |||.|||..   ..||.|| .|| ..|| .|||  |   .   .| | .|| |     .||.| |
gsgsdyinatylk.gfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywps.td..qpaaygvltvslkkkeefsdytvrsl

RVR-NMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREirvRLMGVaVNNPPWptVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELR
 .  ...   .| ..  |.|.|||. ||.  ..|| |  .| .   |   |  .  ||  ..||||||||||....... | . ..    .  . .  . 
llskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniin...rsphv.sesgpw..iihcsagvgrtgiflvidamlrqakekkvvdiynyvysie

EQRAKVVQTEEQYEFCLRTLLE
|.|  ..||..|| |  .|.||
edrpyiiqtkdqyvfihqtile

0043147 (Phosphotyrosine protein) phosphatases II 4078-4293 7.6e-37 122.0 In-house 2-154 (172) alignment
Range on Protein: 4078-4293
Range on HMM: 2-154/172.0
DEQNSYINANHVTFAEegRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEveggkvkcerywptetgeydalvfgdlkislvksvssgnytirgl
|| . ||||... .     .  .|| ||||. |. |||||..|.| ...|..|..                                             
degsdyinasyldlyy..ipdrfiatqgplrntladfwrmlkelgithivnltel.............................................

rvRNMSEDLMRTVWHLQYTAWPDHSVPkTPSSLLDFIDEIREIRvrlmgvaVNNPPWPTVVHCSAGVGRTGVLMLVESELirleQGMrpNPRQTLVELRE
   .  |.|.|......|. ||||.|| ... ||.|.. |.|.        ...|  |..|||||||||||.| .    |    .|.  .. ... ..||
..lydpellerlgiqylylpwpDhgvp.llellleflefidell.......alspggpvlVHCsaGvgRtgtlvaaylml....lgl..sleeavalvre

QRAKVVQTEEQYEFCL
.| ..||...|| |..
kRpgavqnpsqyrfly

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 4078-4298 7.4e-35 115.2 In-house 32-238 (239) alignment
Range on Protein: 4078-4298
Range on HMM: 32-238/239.0
DEQNSYINANHVTfAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYdalvfGDLKISLVKSVSSGNYTIRGL
| .. ||||...    .|    |||.|| .  . ||||||.|..   ..||.|| .|| | || .|||  | .|      .|...| |.    .| || .
dphsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky.....cnlrvtlrktevfadyiirtf

RVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIReiRVRLMGVAvnnpPWptVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELRE
 . .. .   | |.. ..| |||. ||.  ...| .  .|   .  | |      ||  |.|||||||||| ...... | . ..    .  . .  .||
vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit..kdslpgar....pw..vihcsagvgrtgaflvidamlrqakkqktvdifnyvkaire

QRAKVVQTEEQYEFCLRTLLE
.| ..||| ||| |   ..||
drphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 4078-4297 1.1e-34 114.7 In-house 33-238 (239) alignment
Range on Protein: 4078-4297
Range on HMM: 33-238/239.0
DEQNSYINANHVTfAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYdalvfGDLKISLVKSVSSGNYTIRGL
| .. ||||...    .|    |||.|| .  . ||||||.|..   ..||.|| .|| | || .|||  | .|      .|...| |.    .| || .
dphsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky.....cnlrvtlrktevfadyiirtf

RVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIReiRVRLMGVAvnnpPWptVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELRE
 . .. .   | |.. ..| |||. ||.  ...| .  .|   .  | |      ||  |.|||||||||| ...... | . ..    .  . .  .||
vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit..kdslpgar....pw..vihcsagvgrtgaflvidamlrqakkqktvdifnyvkaire

QRAKVVQTEEQYEFCLRTLL
.| ..||| ||| |   ..|
drphmvqtseqyvfihlavl

0044763 (Phosphotyrosine protein) phosphatases II 4078-4297 7.9e-30 99.2 In-house 11-168 (178) alignment
Range on Protein: 4078-4297
Range on HMM: 11-168/178.0
DE----QNSYINANHVTfaeEGrtlWYIAAQGPlpgtvGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGeydalvfgdlkislvksvssgnyt
         ||||....   .|    |.....|      |......|.| . .|..|.|.|.|..|| .|||.|.|                        
nleglersdyinaseil...pg...lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag........................

irglrvrnmsedlmrtvWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRvrlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRleqGMrpNPRQTLV
                 .. ... .|||.||  .. .|.|.. |.|..        .... |..|||||||||.|.|..    . .   |.  .. . . 
.................iqylhipipDhgvpdllehflefvefieeal........dekggpvlVHCsaGvgRsgtlvaaylmkkl...gl..sleeaie

ELREQRAkVVQTEEQYEFCLRTLL
..||.|  .|....|......  |
lvrerRp.ivpnpgqlrqLyefel

subfamily_PTPRA_pd Subfamily PTPRA 4079-4299 4.8e-49 162.0 In-house 84-294 (330) alignment
Range on Protein: 4079-4299
Range on HMM: 84-294/330.0
EQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETgeydALVFGDLKISLVKSVSSGNYTIRGLR
|.  |||| ..   .|  .  .||||||.  || |||||.||| |. .||.|   |  . ||..|||.|     .. .|...... ... . .||.| . 
eesdyinasfidGykekdk..fiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeG....lvtyGnirvevedetvlvdytvrkfl

VRNM----SEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvaVNNppwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVE
|...     |.  | |  . .|.|||  || .|  .|... ...... .       .   | |||||||||||| .. ... | |..   . .  ... .
vqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqq.....sag...pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkr

LREQRAKVVQTEEQYEFCLRTLLEV
|| ||...|||.|||||. ..||| 
lrlqrpqmvqtdeqyefiykvlley

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 4079-4305 1.7e-47 156.7 In-house 69-281 (515) alignment
Range on Protein: 4079-4305
Range on HMM: 69-281/515.0
EQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGeyDALVFGDLKISLVKSVSSGNYTIRGLR
 .. |.|| ..   .  ..  |||.|||.. .| ||||.|...    ..|||   || |.|| .|||   |  |.. || .|..||   . .. ..| |.
Phsdyfnasyipsfdndka..yiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg..dsvkfGsikvelvsleactggikrklt

VRNMSEdlMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLmgvavNnppWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELREQ
|   ..  .|||   ..| |||. |||  |||| .| |..  . ..     .   .| ..|||||||||||.. ..| . . ...   .  ...  .|..
vlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqy.....t...hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqk

RAKVVQTEEQYEFCLRTLLEVARKRQT
| ..|||.||| |   ..||    |.|
rpylvqtqeqyafiygavledllwrnt

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 4079-4304 1.1e-28 94.7 In-house 71-240 (392) alignment
Range on Protein: 4079-4304
Range on HMM: 71-240/392.0
EQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGkvkcerywptetgeydalvfgdlkislvksvssgnytirglr
 .. |.|| ..   .  ..  |||.||| . .. ||||||...    ..|||   ||                                           
pdsdylnasyipsfdneka..yiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........................................

vrnmSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIReirVRLmGvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELREQ
      | .|||   ..| |||. |||  |||| || |..   .   |    .   | ..|||||||||||.. ..| . . ..    .  . ....|..
....kgddartvaqfhftewPdkdvpkhtssllkfikevk...adf.G....qythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrk

RAKVVQTEEQYEFCLRTLLEVARKRQ
|  .|||.||| |   ..||    |.
rpymvqtkeqyafiygavledllwrn

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 4079-4305 3e-19 63.7 In-house 77-295 (310) alignment
Range on Protein: 4079-4305
Range on HMM: 77-295/310.0
EQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtGEYDalVFGDLKISLVkSVSSGNYTIRGLR
  . || ||.|       |  .| .||||  |. |||||.... .. ....   .| |. ||  |||.  |  .   .| .... . | || .. |  | 
ryedyihanyvktnylrst..ficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl.gvte..tygcirvtnl.sesseefeicnla

VRNMSED---------LM-RTVWHLQYTAWPDHSVPKtpsslldfiDEIREIRVRLMGVaVNNPpwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNP
|  . ..         |    |  ...  |||  ||          .    .  ||.   |     | |||||||..|..|.. .. .. .|..| . . 
vtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpd.........ekchtvpqrllaq.vrhg..pcvvhcsagkdrlyvvvalklkidkldrglkvda

RQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKRQT
 .   ||. .||...||| || .  |  .  ||  . 
eevktellksraiciqtelqyliidrvriifargete

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 4079-4147 4.5e-16 53.5 In-house 81-153 (350) alignment
Range on Protein: 4079-4147
Range on HMM: 81-153/350.0
EQNSYINANHVTFA---EEGRTLW-YIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTE
. | |||||..  .    |  . . |||.|.||| || ||.... . . ......| .|| .  ||.|||.  
stnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqeg

0041856 (Phosphotyrosine protein) phosphatases II 4080-4301 2.9e-40 133.2 In-house 18-172 (182) alignment
Range on Protein: 4080-4301
Range on HMM: 18-172/182.0
QNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTgeveggkvkCERYWPtetgeydalvfgdlkislvksvssgnytirglrv
 ..||||| . ..  ...  .||.||||..|| ||.||..|.| ...|..|         .|.|||                                  
dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywp..................................

rnmsEDLMRTVWHLQYTAWPDHSVPKtPSSLLDFIDEIREirvrlmgvavnnPPWPTVVHCSAGVGRTGVLMLVEseLIRLEqgmRPNPRQTLVELREQR
    |.|.|......|. ||||.||  ...|||||.|..|            .. |..|||||||||||.| .    |..     . ...... ..|..|
....ellerlgiqylylpwpDhgvpd.ldelldfieevle............eggpvlVHCsaGvgRtgtlvaay..lmkkl...gvsleeavklvrsrR

AKVVQTEEQYEFCLRTLLEVAR
 ..|.|..|| |. . |||. .
pgmvitpnqyfflqlallelll

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 4080-4307 1.4e-25 84.5 In-house 65-278 (281) alignment
Range on Protein: 4080-4307
Range on HMM: 65-278/281.0
QNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETgeYDALVFGDLKISLVKsvSSGNYTIRGLRV
   || ||..      |   || .|||   |  |||||.|.. .  .||.   .|  . ||  |.| ..  . .| |  | .|     |. | ..   |.
stdyihanyirspflkrg..yiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna..hcclqfdklsvsyed..stvnkslvttrl

RNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFideIREIRVRlmgvavNNppwPTVVHCSAGVGRTGVLMLVESELIRLEQGM-RPNPRQTLVELRE-
    |   | . |  .  |||  ||..   .|     .|.|| |           | |.||||||||.| || ||  |  .   .  |. .| .  ||  
nlsyegetrlithwlwkewpdwqvpessevmlki...lrkirar......st...ppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvt

QRAKVVQTEEQYEFCLRTLLE--VARKRQTAE
 ||  ||| .|| .  . ||.  || |. | |
graasvqtlqqymliwkvlldfgvaykqitee

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 4080-4146 3.6e-11 37.0 In-house 89-155 (349) alignment
Range on Protein: 4080-4146
Range on HMM: 89-155/349.0
QNSYINANHVTFAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPT
 . |||||.. ...      ||| | ||| || ||....  .| ..|. .. . | .  ||..||  
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 4080-4146 1e-07 25.8 In-house 121-180 (244) alignment
Range on Protein: 4080-4146
Range on HMM: 121-180/244.0
QNSYINANHVTFAeeGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVmVTGEVEggkvKCERYWPT
 |.||||  |     |||  || .| ||  |  |||.|. |.  ...| | | ||    . . ||| 
gntyinasfvgcl..grtaeyiltqhpladtsmdfwkmmlerhvnvlv.vlgsve....eedeywpd

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 4080-4147 9e-06 20.0 In-house 12-72 (130) alignment
Range on Protein: 4080-4147
Range on HMM: 12-72/130.0
QNSYINANHVTFAeeGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVmVTGEVEggkvKCERYWPTE
.| ||||. |     |||  |. .| ||  |  |||.|. |.   ..| | | ||    . . |||  
gntyinasfvGll..grtaeylltqhpladtsmdfwkmmleryvnvlv.vlgsve....eedeywpds

0051429 (Phosphotyrosine protein) phosphatases II 4081-4306 9.9e-45 148.6 In-house 4-231 (272) alignment
Range on Protein: 4081-4306
Range on HMM: 4-231/272.0
NSYINANHVTFAeeGR---TLWYIAAQGPLPGTVGDFWRMvWEQGSQIVVMVTGEVEGGKVKCERYWP--------TETGEYDALVFGDLKISLVKSVSS
..||||..|     ||      .....|||| |. ||||. .|.|   .|....|.| |..||.||||        ..  ..    .|.| . |.. .  
sgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

GNYTIRGLRVRNM-SEDLMRTVWHLQYTAWPDHSVPKTPssLLDFIDEIREirvrlmgvavnnpPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPN-
 .|..| |..... | . .|.|.||.||.||||.||. .  ||........             . | .||||||..|||.. ..   | ...     . 
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.............ggpvlvHCsaGkdRTGtvvallllllgvsletivdd

-------PRQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKRQTA
       ..... |||.||...|||||||.|... |||..|. ...
Ylltnlyleeaveelraqrpgavqteeqylflyeallellrsllsv

0036282 (Phosphotyrosine protein) phosphatases II 4081-4293 4.4e-39 129.3 In-house 2-163 (174) alignment
Range on Protein: 4081-4293
Range on HMM: 2-163/174.0
NSYINANHVTFAEEGRtlWYIAAQGPLPgtvgdFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTetgeydalvfgdlkislvksvssgnytirglrvr
..||||... . .  .   .|| ||||.     ||.|..|.|...|||.. |.| |..|| .|||.                                  
sdyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................

nMSEDLMRTVWHLQYTAWPDHSVPKTPSsLLDFIDEIREIRVRlmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRLEqgmrPNPRQTLVELR---E
 ..||| |......|. ||||.|| ..  ||.|.....|.. .       .|  |..|||||||||||.|..    | .|.    ..... |  .|    
.lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.......dpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRl

QRAKVVQTEEQYEFCL
|| ..|||..||.|. 
qrpgmvqtpsQyrfly

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 4081-4298 6.1e-33 108.9 In-house 76-277 (439) alignment
Range on Protein: 4081-4298
Range on HMM: 76-277/439.0
NSYINANHVTFAEEGRtlWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKvkcerYWPTEtgeyDALVFGDLKISLVKSVSSGNYTIRGLRVR
  |||||..    . .   |||.|||   |. ||||.|.|. .  .||.|  ||  |     |||..    .  ..||. .   . .   ||.|||..| 
shyinanyikGyyddk..lyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsd....aevcygdiavrvdrnielpnyvirgfkvf

NMSE--DLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREirvrlmgVAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELREQ
|  .  .  ||| ...|.||||. ||   | .|||.  |            ..   | |||||||||||| .. ..  | .|    . . .  .  ||.|
nerdttekertvlqfhyiawpdknvpaqashvldflrains.......andkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkq

RAKVVQTEEQYEFCLRTLLE
| ..||.  || |   ..||
rkqmvqalcqyvfiynavle

0049772 (Phosphotyrosine protein) phosphatases II 4081-4300 9.3e-31 103.1 In-house 72-280 (314) alignment
Range on Protein: 4081-4300
Range on HMM: 72-280/314.0
NSYINANHVTFAeegrtLWYIAAQGPLPGTVGDF----------WRMV--WEQGSQIVVM---------------------VTGEVEGGkvkcerywpte
 .||||..|        | .||.||||. || ||          ||||  ... . ..||                      ..  ..|           
sdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...........

tGEYDALVFGDLKislvksvssgnytirglRVRNMSEDLMRTVWHLQYTAWPDHSVPkTPSSLLDFIDEIREIrvrlmgvavnNPPWPTVVHCSAGVGRT
 .|..|  . .||                 .. .  |.. |.. .. .. .||.|.| ... ...|.. |.|           ... |..|||.||.|||
.neptaadlellk.................eelydpelferlgikylripvpDgsap.lledfdeflefieea..........dkggpvlvHCkaGkgRt

GVLMLVESelIRLEQGMrpNPRQTLVELREQRA-----KVVQTEEQYEFCLRTLLEVA
|.....    . . .|.  .....| ..|..|        ... |||||.|. |||  
gtfvvaay..lmkllgv..sleealedvrlkRpinpnpgfieqleqyefilealleyl

0051082 (Phosphotyrosine protein) phosphatases II 4081-4297 1.7e-30 101.0 In-house 3-150 (151) alignment
Range on Protein: 4081-4297
Range on HMM: 3-150/151.0
NSYINANHVTfaeEGrtlwYIAAQGPLPgtvgDFWRMVWEQGSQIVVMVTGEVEGGkvKCERYWPTETgeydalvfgdlkislvksvssgnytirglrvr
..|||.. ||   .|    ... .|||.    ||.....|.| . .|....|.| |  .| .|.| .                                 
sdyinfsyvt...gg....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

nmsedlmRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREirvrlmgvavnNPPWPTVVHCSAGVGRTGVLMLVEseliRLEQGmrPNPRQTLVELREQRA
       ..|.|.... |||...| .. ..|.|......           ... |..||||||.||||.|...     .. .|   .. ..| |.|..| 
.......ievlhipildwpdpglplsfdavleflellld...........kkngpvlvHCsaGkgRTGtlvaly....lmllg..vsleealeeyrlkrp

KVVQTEEQYEFCLRTLL
 |||...|. |.|. ||
gvvqpnqqflfqlfall

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 4081-4306 2.4e-25 83.9 In-house 73-293 (305) alignment
Range on Protein: 4081-4306
Range on HMM: 73-293/305.0
NSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDALVFGDLKISlVKSVSSGNYTIRGLRVR
  || ||.|.   . .   .| .| ||  |  ||| | ...  . . |.   .| |  ||  |.... ..   .  .. ||| ||  ||... .|     
heyihanyvstptnpkr..fictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkis.vkfessvtlkfrkdaka

NMSE---------DLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRvrlmGvavnnppwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRP-NPRQ
...|           .| | |  .  |||  || .  ..|... . |  .    |        |.|||||||.|||| ....|  | .| .|    .  .
kvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk....g........pivvhcsagigrtgsvvmleyildqllagqiiedtdk

TLVELREQRAKVVQTEEQYEFCLRTLLEVARKRQTA
 |. .|||| . .||..|| |  . .|.  ||..  
ilqkireqrnnsiqtdaqylfvhqvilnyfrkkkll

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 4081-4295 1.1e-15 52.5 In-house 46-254 (290) alignment
Range on Protein: 4081-4295
Range on HMM: 46-254/290.0
NSYINANHVTFAEEgrtLWYIAAQGPLP-------GTVGDFWRMVWEQGSQIVVMVTgEVEGGKV-----KCERYWPTETGEydALVFGDLKISLVKSVS
. || ||.||...    |  |. | |.         |. .|| |. .  .. |||.  |.|  .       |..| |.. ||   | |..|...  . . 
ddyiHAnrvtcpng...lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlc.efeeksantslfaCakYvpesvge..elkfkgltvkCkskek

SGNYTIRGLRVRnMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIreirvrlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLE-QGMRPN
  .  .| | |.   ..   || | ..  | . .|.... .||. |. .            ..   | .|||  |. |  .|  ..     .  .    .
eddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkv............kasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvk

PRQTLVELREQRAKVVQTEEQYEFCLRT
 .. | .||.|||......... | .  
ledvlkalrkqralaitsalelafvdag

0049260 (Phosphotyrosine protein) phosphatases II 4098-4293 2e-33 110.6 In-house 9-143 (152) alignment
Range on Protein: 4098-4293
Range on HMM: 9-143/152.0
LWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWptetgeydalvfgdlkislvksvssgnytirglrvrnmsedlmrtvwHLQYTA
  .||.|||.| |. |||||..|.| ...||.| ..| ||.|||.|.                                               . ... 
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...............................................qylhlp

WPDHSVPKTPSSLLDFIDEIREIrvrlmgvaVNNPPWPTVVHCSAGVGRTGVLMLVESELirleqgMRPNPRQTLVELREQRAKVVQTEEQYEFCL
||||.||. .  ||.... |...          ..  |..|||||||||||.|..    |      .. .. ...  .||.| ..|....|..|..
wpDhgvpdlsqlllflllfiekl........aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 4099-4253 6.2e-18 59.7 In-house 5-154 (198) alignment
Range on Protein: 4099-4253
Range on HMM: 5-154/198.0
WYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgEYDALVFGDLKISLVKSVSSGNYTIRGLRVRNMS--EDLMRTVWHLQYT
 |||.| ||  |. |||.|||| ||  .|||  .    ..    ||||   |  .  .| | ..    ..  .|||  | . | .      | . | |.|
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywptt..esgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

AWPDHSVPKTpSSLLDFIDEIREIRVRLMgvavNNPPWPTVVHCSAGVGRTGVLMLV
.| ... |.  . .. |.   ||.  .      ..   | .|||| | | |||.. .
swkekttpnv.alfvgfvvasrevskkye....qekdapvivhcsdgqgftgvfval

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 4099-4253 6.3e-18 59.7 In-house 6-155 (199) alignment
Range on Protein: 4099-4253
Range on HMM: 6-155/199.0
WYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgEYDALVFGDLKISLVKSVSSGNYTIRGLRVRNMS--EDLMRTVWHLQYT
 |||.| ||  |. |||.|||| ||  .|||  .    ..    ||||   |  .  .| | ..    ..  .|||  | . | .      | . | |.|
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywptt..esgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

AWPDHSVPKTpSSLLDFIDEIREIRVRLMgvavNNPPWPTVVHCSAGVGRTGVLMLV
.| ... |.  . .. |.   ||.  .      ..   | .|||| | | |||.. .
swkekttpnv.alfvgfvvasrevskkye....qekdapvivhcsdgqgftgvfval

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 4102-4300 2.1e-18 61.3 In-house 39-221 (255) alignment
Range on Protein: 4102-4300
Range on HMM: 39-221/255.0
AaqgplpgTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLVKsvSSGNYTIRGLRVR-NMS-EDLMRTVWHLQYTAWP
        ||  |....  .... |||..   | |..||..|.|.|  |   |.. |....  |  || .  .| |..  ...     .|| | .|. |.
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekde..klkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWi

DHSVPKTPsslldfideiREIRvRLMGVAVNNppWPTVVHCSAGVGRTGVLMLVESELIRLEQGMR------PNPRQTLVELREQRAKVVQTEEQYEFCL
..  |. .          |||.  .. |. .    . |||||.|.||.  ..|.|.   .. . ..       . .. | |||..|.. ..|  |  |..
eknaPela..........reil.nilkvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsi

RTLLEVA
 ..|.. 
lmvldlv

subfamily_hpo-7_pd Subfamily hpo-7 4109-4299 9.6e-15 49.2 In-house 45-226 (263) alignment
Range on Protein: 4109-4299
Range on HMM: 45-226/263.0
GTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLVKSVSsgNYTIRGLRVRNMSE--DLMRTVWHLQYTAWPDHSVPKT
 |.  |....  .... |||..   | |..||..|.|.|  |   ... .....  |..|  .  .. | . .. .    ..|| | .|. |...  |. 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekde..kqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

PSSLLDFIDEIREIRvrlmgvavnnppwPTVVHCSAGVGRTGVLMLVESELIRLEQGMR------PNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEV
. . |  ..  |. .             . |||||.|.||.    ..|.   .. . ..       . .. | |||..|.. ..|  |  | . ..|..
areilnilkvarnsk.............slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdf

0048076 (Phosphotyrosine protein) phosphatases II 4154-4296 4.5e-22 73.7 In-house 11-139 (145) alignment
Range on Protein: 4154-4296
Range on HMM: 11-139/145.0
LVFGDLK------------ISLVKSVssgnytirglrvRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvavnnpPWPTVVHCS
| .|.|             | .| ..             .. |.| |......|. ||||.||  .. ||.|.. |.|.. .         . |..||||
lylgslptaldlellkdlgittvlnl............tselellerlgiqylylpwpDhgvpdllellleflefieealke.........ggpvlVHCs

AGVGRTGVLMLVEseLIRLeqgMRPNPRQTLVELREQRAKVVQTEEQYEFCLRTL
|||||||.|..    |..|   .. .. ..| ..|.|| ..|....|..|... .
aGvgRtgtlvaay..lmll...lgvsleealelvrsqrpgavpnpgqlrflyefe

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 4164-4298 5.9e-13 42.9 In-house 69-192 (440) alignment
Range on Protein: 4164-4298
Range on HMM: 69-192/440.0
VKSVSSGNYtirgLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvAVNNppwPTVVHCSAGVGRTGVLMLVESELIRLEQG
||.| . .|    .    ..    ||. . .| .|||..|||  . .| .|... | . .    | |    | .||||||.|||||.. |.| |   .. 
vkgvpdsdy....inasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqek....agng...pllvhcsagagrtgviiavdsilreakrs

MRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLE
 . .    .  .|..| ..||| ||| |   ..||
dqidifsfinsmrnnrpqmvqtpeqyafvheavle

0048179 (Phosphotyrosine protein) phosphatases II 4166-4294 9e-21 69.5 In-house 25-139 (144) alignment
Range on Protein: 4166-4294
Range on HMM: 25-139/144.0
SVSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIrvrlmgvavNNPPWPTVVHCSAGVGRTGVLMLVEselIRLEQGmr
  . | .|.  |.     |.| |........ ||||.||  .. ||.|.. |.|.          ... |..|||||||||||.|..     . ...|  
lkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieea.........leeggpvlVHCsaGvgRtgtlvaay...lmkklg..

PNPRQTLVELREQRAKVVQTEEQYEFCLR
 .. ..| ..|..|  .|....|..|.|.
lsleealalvrsrrpgavpnpgqlrfLle

subfamily_PTPDC1_pd Subfamily PTPDC1 4184-4294 3.7e-08 28.0 In-house 76-170 (182) alignment
Range on Protein: 4184-4294
Range on HMM: 76-170/182.0
EDLMRTVWHLQYTAWPDHSVPkTPSSLLDFideireirVRLMGVAVNNPpwPTVVHCSAGVGRTGVLMlvESELIrLEQGMrpNPRQTLVELREQRAKVV
|.||..       .|.|..|. .  ..||         |...  |...    . ||| || ||||||.   . |.   . .  .. ...  .|..|.| .
ealmeqgiyvynfgwkDygva.sleriLdi........vkvvafalqeg..kvavhChaGlGrtGvli..acylv.yakrl..taekaiklvrskrpksi

QTEEQYEFCLR
|| || |..  
qtreqvelvke

0038934 (Phosphotyrosine protein) phosphatases II 4185-4292 5.8e-07 24.9 In-house 74-169 (194) alignment
Range on Protein: 4185-4292
Range on HMM: 74-169/194.0
DLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvavnNPPWPTVVHCSAGVGRTGVLMLveSELIRLeQGMrpNPRQTLVELREQRAKVVQ
....   .     .||. .. . . ||.|.| . |.  .       .|.   .||| ||.||||.|    . ||   .||  .... .  .|| | ....
efekagieylklpfpddgtvPsleillrfldlvdeflne.......dpggvvaVHCkaGlgRtGtlva..aYLiyr.lgm..saeeAialfrekRpgaip

TEEQYEFC
. ...|  
nqdyleal

PTPc_DSPc_SM00012 4189-4298 1.4e-27 91.3 In-house 1-105 (105) alignment
Range on Protein: 4189-4298
Range on HMM: 1-105/105.0
TVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGvavnnpPWPTVVHCSAGVGRTGVLMLVESELIRLEQG-MRPNPRQTLVELREQRAKVVQTEE
|| |..||.||||.||....|.|........ .             |.||||||||||||......  | .||..  ...  |.. |||.||...|||||
tvkhyhytgwpdhgvPeesdsilellravkknknkses......skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqtee

QYEFCLRTLLE
|| |..| |||
qylflyralle

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 4189-4300 4e-12 40.5 In-house 216-344 (350) alignment
Range on Protein: 4189-4300
Range on HMM: 216-344/350.0
TVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMG--VAVNNPPWPTVVHCSAGVGRTGVLMLVESELI---RL-------EQGMRPN-----PRQT
 |..||.  |.| |.   | |.|  ..   ..   |.      |.   | .|||||||||||.|. ..| |     |       ..  ...       ..
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

LVELREQRAKVVQTEEQYEFCLRTLLEVA
. |||.|| ..||. .|. |.  .||   
vnelrkqrismvqnldqfifiYeallfyf

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 4189-4299 6.3e-08 26.3 In-house 219-343 (349) alignment
Range on Protein: 4189-4299
Range on HMM: 219-343/349.0
TVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMG-VAVNNPPW-PTVVHCSAGVGRTGVLMLVESELIRLEQ-----------GMRPNP-RQTLVE
 .. ||.  |.| |.   | |.|  ..   ..   |.    ...    . .|||||| ||||||. ... |  ||             .. ..   .. |
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

LREQRAKVVQTEEQYEFCLRTLLEV
|| ||  .||   |. ... .||. 
lrkqrismvqnlaqfiaiyealLky

subfamily_CG42327_pd Subfamily CG42327 4235-4301 8.9e-12 39.3 In-house 249-316 (319) alignment
Range on Protein: 4235-4301
Range on HMM: 249-316/319.0
PTVVHCSAGVGRTGVLMLVESELIRLEQGMR-PNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVAR
| ||||| ||||||...  . .. .||.  |  .  |..  .|..||. |.| |||||  ..| | |.
PlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak