Gene MbrePTP-Un-11 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP052_AA protein Get Run
MbreP052_AA_4066-4301 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
EGF EGF-like domain 9-40 2.5e-07 18.1 Pfam-A 1-31 (32) alignment 
Range on Protein: 9-40
Range on HMM: 1-31/32.0
CDRLgqPCQNGATCNDQT-DGYSCSCAFGYTGA
|.    ||.||.||.|   .||.| |. |||| 
Cspn..pCsngGtCvdtpgggytCeCpeGytGk
EGF EGF-like domain 49-79 2.8e-09 24.4 Pfam-A 1-31 (32) alignment 
Range on Protein: 49-79
Range on HMM: 1-31/32.0
CASNPCVNGGTCSQSAAGSYECSCSTGWTGD
|..||| ||||| ..  |.|.| |  |.||.
CspnpCsngGtCvdtpgggytCeCpeGytGk
EGF_2 EGF-like domain 49-81 2e-06 14.5 Pfam-A 1-32 (32) alignment 
Range on Protein: 49-81
Range on HMM: 1-32/32.0
CASN--PCVNGGTCSQSaagSYECSCSTGWTGDDC
| ..   | ..||| ..      |.|. |..|..|
CsadgliCgghGtCvkq...cgkCvCdsgyqGktC
EGF_CA Calcium-binding EGF domain 84-124 4.8e-06 13.1 Pfam-A 1-42 (42) alignment 
Range on Protein: 84-124
Range on HMM: 1-42/42.0
DIDECASAP--CKNGGSCSQpVVGAFACACTAGYSGPTCESEC
|.||||| .  |.....|.   .| | | | .||.  . |..|
DvdECasgthnCpentvCvN.teGsfeCvCeegyennedetkC
EGF EGF-like domain 88-119 4.8e-08 20.4 Pfam-A 1-32 (32) alignment 
Range on Protein: 88-119
Range on HMM: 1-32/32.0
CASAPCKNGGSCSQPVVGAFACACTAGYSGPT
|.. ||.||| | .   | . | |. ||.|..
CspnpCsngGtCvdtpgggytCeCpeGytGkr
EGF_2 EGF-like domain 88-120 8.3e-06 12.5 Pfam-A 1-32 (32) alignment 
Range on Protein: 88-120
Range on HMM: 1-32/32.0
CAS--APCKNGGSCSQPvvgafA--CACTAGYSGPTC
| .  . | ..|.| ..        | |..||.|.||
CsadgliCgghGtCvkq.....cgkCvCdsgyqGktC
EGF EGF-like domain 1116-1144 1.3e-06 15.8 Pfam-A 1-30 (32) alignment 
Range on Protein: 1116-1144
Range on HMM: 1-30/32.0
CLDCPCEQGAPCTQSG-NGYQCECPAGYTG
| . ||  |. |.... .||.|||| ||||
CspnpCsngGtCvdtpgggytCeCpeGytG
hEGF Human growth factor-like EGF 1135-1147 1.8e-06 16.7 Pfam-A 1-13 (13) alignment 
Range on Protein: 1135-1147
Range on HMM: 1-13/13.0
QCECPAGYTGVNC
.|.||.|||| ||
tCqCppGyTGpnC
EGF_CA Calcium-binding EGF domain 1150-1181 2.7e-06 13.9 Pfam-A 1-34 (42) alignment 
Range on Protein: 1150-1181
Range on HMM: 1-34/42.0
DINECADVP--CSFGSTCVNLVANYSCVCWAGLS
|..|||. .  |. ...||| .  ..||| .| .
DvdECasgthnCpentvCvNteGsfeCvCeegye
EGF EGF-like domain 1207-1229 5.7e-08 20.2 Pfam-A 4-30 (32) alignment 
Range on Protein: 1207-1229
Range on HMM: 4-30/32.0
DPCMNGGSCQPSG----SCSCAMGYTG
.||.||| |....    .| |..||||
npCsngGtCvdtpgggytCeCpeGytG
EGF_CA Calcium-binding EGF domain 1235-1266 1.3e-08 21.3 Pfam-A 1-34 (42) alignment 
Range on Protein: 1235-1266
Range on HMM: 1-34/42.0
DIDECADEP--CLNGGQCEDGIGSYSCTCAEGFE
|.||||...  | ....|.  .||..|.| ||.|
DvdECasgthnCpentvCvNteGsfeCvCeegye
EGF EGF-like domain 1239-1268 1.3e-10 28.6 Pfam-A 1-31 (32) alignment 
Range on Protein: 1239-1268
Range on HMM: 1-31/32.0
CADEPCLNGGQCEDGI-GSYSCTCAEGFEGD
|...||.|||.| |.  |.|.|.|.||. |.
CspnpCsngGtCvdtpgggytCeCpeGytGk
EGF EGF-like domain 1277-1306 1.2e-08 22.4 Pfam-A 1-31 (32) alignment 
Range on Protein: 1277-1306
Range on HMM: 1-31/32.0
CENNNCAMGSTCVDGI-NSYTCACVPGYTGI
|  |.|  | ||||.  ..||| | .||||.
CspnpCsngGtCvdtpgggytCeCpeGytGk
EGF EGF-like domain 1315-1344 1.2e-09 25.6 Pfam-A 1-31 (32) alignment 
Range on Protein: 1315-1344
Range on HMM: 1-31/32.0
CEPVPCHNGATCTEGI-NTFTCTCASGFGGS
| | ||.||.||...  ...||.|..|. | 
CspnpCsngGtCvdtpgggytCeCpeGytGk
EGF_2 EGF-like domain 1722-1747 4.1e-08 19.8 Pfam-A 7-32 (32) alignment 
Range on Protein: 1722-1747
Range on HMM: 7-32/32.0
PCQNGGTCLTSSGLCQCTDSYTGSAC
 |...||| .. | |.|...|.|  |
iCgghGtCvkqcgkCvCdsgyqGktC
EGF EGF-like domain 3698-3725 2.4e-06 15.0 Pfam-A 1-29 (32) alignment 
Range on Protein: 3698-3725
Range on HMM: 1-29/32.0
CALDPCLSGGSCIKEF-FDYRCVCAPGYL
|. .||. || |.     .|.| |..|| 
CspnpCsngGtCvdtpgggytCeCpeGyt
EGF EGF-like domain 3738-3766 2.9e-09 24.3 Pfam-A 3-32 (32) alignment 
Range on Protein: 3738-3766
Range on HMM: 3-32/32.0
GHDCQNGATCVDGV-DGYYCACAPGFDGET
 . |.||.||||.  .||.| |..|..|..
pnpCsngGtCvdtpgggytCeCpeGytGkr
EGF EGF-like domain 3774-3803 5.2e-08 20.3 Pfam-A 1-31 (32) alignment 
Range on Protein: 3774-3803
Range on HMM: 1-31/32.0
CTESACAHGGTCVDEV-HGYSCECPTGYRGD
|..  | .||||||   .||.|||| || |.
CspnpCsngGtCvdtpgggytCeCpeGytGk
EGF_2 EGF-like domain 3774-3805 3.2e-06 13.8 Pfam-A 1-32 (32) alignment 
Range on Protein: 3774-3805
Range on HMM: 1-32/32.0
CTES--ACAHGGTCVDEvhGYSCECPTGYRGDFC
| ..   | ..||||..     |.|. || |. |
CsadgliCgghGtCvkq..cgkCvCdsgyqGktC
EGF EGF-like domain 3898-3924 7.9e-09 22.9 Pfam-A 4-31 (32) alignment 
Range on Protein: 3898-3924
Range on HMM: 4-31/32.0
TPCLHGGTCLDKV-NGFACTCPTTYFGD
.||..||||.|   .|. |.||  | |.
npCsngGtCvdtpgggytCeCpeGytGk
EGF_2 EGF-like domain 3935-3960 6e-06 12.9 Pfam-A 7-32 (32) alignment 
Range on Protein: 3935-3960
Range on HMM: 7-32/32.0
PCRNGGTPNRTTARCECTSGFEGRFC
 | ..|| .... .|.|.||. |  |
iCgghGtCvkqcgkCvCdsgyqGktC
subfamily_egg_pd Subfamily egg 4066-4298 7.7e-20 65.8 In-house 65-268 (307) alignment 
Range on Protein: 4066-4298
Range on HMM: 65-268/307.0
EYANddtlvhlqdeqnSYINANHVTfaeeGRTL--WYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGgkVKCERYWPTETGEYDALVFGDLKISL
 |..             .| ||.|     |. |   .| || ||  || ||||||...  | .||.|  .|    .|| |||    .   .| | |.|  
qyld............dfihanrvk....Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrien

VKSVSS--GNYTIRGLRVrNMSEDLMRTVWHLQYTaWPDHSVPKTPSSLLdfideiREIRvrlmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRLE
.|  |     ...  |..   ..|  | . | |.  .   |   .|  .|      | .|         |   |.||..  || ....|. .|  |. | 
lkvdskadplfrvtklkl.vGgddeerflehwqgd.vnnssdvysplrvl......rklr.........nlskpvvvqdilGvskaatlvaieiallsll

QGM--RPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLE
.|   .   ... | || .|   |..  .| |  | .| 
rGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf
0050432 (Phosphotyrosine protein) phosphatases II 4067-4304 1.1e-77 256.8 In-house 78-303 (308) alignment 
Range on Protein: 4067-4304
Range on HMM: 78-303/308.0
YANDDTLVHLqDEQNSYINANHVTFAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEyDALVFGDLKISLVKS
...| . |.| || ..||||..|..   ...  .||.|||||.||.|||||||||.....||.| .|| |..||..|||.|.|. . |..|.... |.. 
lpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgg.gsleygkftvtllse

VSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRvrlmgvavnnPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRP
 . ..||.| |...|.... .|||.|..||.||||.||  |..||||....|. .          |. |.||||||||||||.. ...  | .||.. ..
evlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..........pggpivVHCsaGvGRtGtfialdllleqlekeggv

NPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKRQ
.. ...  |||||. .|||.|||.|. |.||| .....
dvfeavkklReqRpgmvqtpeqylflyralleylklkl
0036941 (Phosphotyrosine protein) phosphatases II 4067-4304 3.2e-74 245.2 In-house 49-281 (297) alignment 
Range on Protein: 4067-4304
Range on HMM: 49-281/297.0
YANDDTLVHLQDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDAlvFGDLKISLVKS
...|.| |.|.|| ..||||..|.. . .|.  .||.|||||.||.|||||||||.....||.| .|| |..||..|||.|.||.    .||... |.. 
lpydhtRVklddegsdYinAsyvdgydlkrk..fIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegeslt..ygdftvtllsv

VS--SGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRvrlmgvAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLE---
 .  ...||.| |.| .. ..  |||.|..|| ||||.|| .|.||||||...|...      .  ... |..|||||||||.|.. ...  | .||   
evvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl......kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledkl

QGMRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKRQ
   .... ... .|||||. .|||.|||.|. ..|||  .|. 
keggvdileavkklReqRpgavqtleqyrflyeallellkkkl
0040438 (Phosphotyrosine protein) phosphatases II 4067-4303 7.2e-74 244.2 In-house 53-279 (317) alignment 
Range on Protein: 4067-4303
Range on HMM: 53-279/317.0
YANDDTLVHLQDEQ----NSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTetgeYDALVFGDLKIS
. .|.. |.|....    ..||||..|.. ...|.  .||.|||||.||.||||||||||....||.| ..| |..||..|||.     . |..||... 
lpydhsRVkLsplggdldsdYInAsyvdgpnlkrk..fIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl....getltygdftvt

LVKSVSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRvrlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQ
|.. .  ...|.| |.| .. ..  |||.|..||.||||.||..|..||||....|| .        ..|. |..|||||||||||.. ...  | .||.
llseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal........edpggpvlVHCsaGvgRtGtfiaaylmleqlek

GMRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKR
...... ... ||||||...|||.|||.|. . |||  ...
eggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
0046845 (Phosphotyrosine protein) phosphatases II 4067-4303 7.2e-73 240.7 In-house 38-277 (284) alignment 
Range on Protein: 4067-4303
Range on HMM: 38-277/284.0
YANDDTLVHLQD-----EQNSYINANHVTFAEE---GRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgeYDALVFGD
...|.. |.|.      | ..||||..|.. .     ..  .||.|||||.||.|||||||||.....||.|..|| |..||..|||.|    . |..||
lpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple...gevltygd

LKISLVKSVSSGNYTIRGLRVRNMS-EDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESEL
... |..    ..||.| |...|.. ..  |||.|..||.||||.|| .|..||.|....||.. .      .... |.||||||||||||.. ...  |
ftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen......lpgggpivVHCsaGvgRtGtfialdlll

IRLEQGM---RPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKR
 .||..    .... ...  |||||   |||.|||.|. ..||| ....
eqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
0047943 (Phosphotyrosine protein) phosphatases II 4067-4298 9.3e-72 237.1 In-house 48-270 (273) alignment 
Range on Protein: 4067-4298
Range on HMM: 48-270/273.0
YANDDTLVHLQDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEyDALVFGDLKISLVKS
...|.. |.|.|. ..||||..|.. . .|.  .||.|||||.||.|||||||||.....||.| .|| |..||..|||.| ||   |..|.... |.. 
lpydhsrvklgdggsdyinAsyvdgynlkrk..fiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwplegge.lsltygkftvtllse

VSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGVavnnppWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRP
 . ..||.| |...|.. .  |||.|..|| ||||.|| ...|||.||...|...  |..        |.||||||||||||.. ...  | .|| . ..
etkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn......gpvvVHCsaGvgRtgtfialdllldqlekeggv

NPRQTLVELREQRAKVVQTEEQYEFCLRTLLE
.. ...  ||.||  .|||.|||.|. ..|||
dvleavkllrsqRpgmvqtpeqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 4067-4302 4.7e-70 231.7 In-house 66-291 (297) alignment 
Range on Protein: 4067-4302
Range on HMM: 66-291/297.0
YANDDTLVHLQDEQN-----SYINANHVTFAEE-GRtlWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKvKCERYWPTETGeydalVFGDLK
...|.. |.|..| .     .||||..|.. .  .|   .||.|||||.||.||||||||||....||.| .|| |. ||..|||.|.|     ..||..
lpydhsrvklkpedgvdldsdYinAsyvdgydlltr..kfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.....tygdft

ISLVKSVSSGNYTIRGLRVRNmsEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRL
. |.|    ..||.| |.|.|  ..  |||.|.||| ||||.|| ....||.|....||.. .|      ... |..|||||||||||.. .    | .|
vtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealael......pkggpvlVHCsaGvgRtGtfiaaylmleql

EQGMRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVARK
| . .... ... |||||| ..|||..||.|. . |||  ..
ekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0045450 (Phosphotyrosine protein) phosphatases II 4067-4299 6.3e-69 228.4 In-house 65-303 (307) alignment 
Range on Protein: 4067-4299
Range on HMM: 65-303/307.0
YANDDTLVHLQD-----EQNSYINANHVTF------AEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgeYDALV
...|.| |.|..     | ..||||..|..          ... .||.|||||.|| |||||.||||....||.|..|| |..|| .|||.|    . |.
lpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde...geelt

FGDLKISLVKSVSSGNYTIRGLRVRNM-SEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvavNNPPWPTVVHCSAGVGRTGVLMLVE
.|.... |..    ..||.| |.| ..  ..  |||.|..||.||||.||.....|||||.|.|... .      .... |..|||||||||||....  
ygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkalee......lpkggpvlVHCsaGvgRtGtfiaay

SELIRLEQGMR---PNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEV
  | .||..     ....... .||||| ..||..|||.|. . ||| 
lmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0045098 (Phosphotyrosine protein) phosphatases II 4067-4301 1e-63 210.7 In-house 43-273 (278) alignment 
Range on Protein: 4067-4301
Range on HMM: 43-273/278.0
YANDDTLVHlqdeqnSYINANHVTFAeegrTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPtEtgeYDALVFGDLKISLVKS
...| . |.       ||||.....     .  .||.||||| || |||||.||.|....||.|..||.|..||..||| |    . |..||... |.. 
lpydhsrVk......dYINAsyidgy....pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.e...ggsltygdftvtllse

VSSGNYTIRGLRVRNM----SEDLMRTVWHLQYTAWPDHSVPKTP--SSLLDFIDEIREIRVRLMGVAV-----NNPPWPTVVHCSAGVGRTGVLMLVES
   ..||.| |.|.|     ...  |.|.||.|. ||||.|| .|  .|.|.....||| . .|... .     .... |..|||||||||||.| ..  
evlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaayl

ELIRLeqGMRPNPRQTLVELREQRAK-VVQTEEQYEFCLRTLLEVAR
 | .|  . . .. ... |||.||   .||..|||.|. . |||. .
mlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
0037934 (Phosphotyrosine protein) phosphatases II 4067-4298 1.5e-63 209.9 In-house 20-240 (243) alignment 
Range on Protein: 4067-4298
Range on HMM: 20-240/243.0
YANDDTLVHLQDeqNSYINANHVTFAEegRtlwYIAAQGPLPGTVGD----FWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPtetGEYdalVFGDLKIS
...|.. |.|..  ..|||||...  .  |   .|| |||||.|| |    ||||.||.|....||.| .|| |..||..|||   ||.   ..||... 
lpydhsrvkleg..sdyinanliyvtp..r...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gev...tygdftvt

LVKSVSSGNYTIRGLRVRNMS-EDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGVAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLe
|... . ..||.| |...| . .|| |.|.|..|..||||.|| .|..||||.||.||.  .|. . ....  |..|||||||||||.| .    | .| 
llseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll.

qgmRPNPRQTLVELREQRAK-VVQTEEQYEFCLRTLLE
   . .. ... .|||||   .|||..||.|. . |||
...gvdleeavkllreqRpgkavqtpsqyrflyealle
0051299 (Phosphotyrosine protein) phosphatases II 4068-4300 2.8e-73 242.2 In-house 60-286 (288) alignment 
Range on Protein: 4068-4300
Range on HMM: 60-286/288.0
ANDDTLVHLQD----EQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTetgeYDALVFGDLKISL
..|.. |.|..    | ..||||..... . .|.  .||.|||||.||.|||||||||.....||.|..|| |..||..|||.     . |..||... |
pydhsRVkLsvldgvegsdYinAsyidgynlkrk..fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl....ggsltygditvtl

VKSVSSGNYTIRGLRVRNM----SEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVrlmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIR
.. .. ..||.| |.|.|.     ..  |||.|..||.||||.|| .|..||||. ..|. .         ... |.||||||||||||.. ...  | .
lseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala........sgggpvvVHCsaGvgRtgtfialdllleq

LEQGMRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVA
||.. .... ...  |||||  .|||.|||.|. ..||| .
lekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0043336 (Phosphotyrosine protein) phosphatases II 4068-4298 1.1e-68 227.0 In-house 56-275 (278) alignment 
Range on Protein: 4068-4298
Range on HMM: 56-275/278.0
ANDDTLVHLQDEQ----NSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPtetgeYDALVFGDLKISL
..| ..|.|....    ..||||..|.. . .|.  .||.|||||.||.||||||||.|....||.|..|| |.||| .|||      . |..||... |
pydhsrvklsllggdldsdYinAsyvdgynvprk..fiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.....ggsltygdftvtl

VKSVSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRvrlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQG
.|  . ..||.| |.| |. ..  |||.|..|..||||.|| ..|.||||. ..||..        .... |..|||||||||||......  | .|| .
lkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal........edsngpvlVHCsaGvgRTGtfialyllleqleke

MRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLE
 .... ... ||||||.. |||..||.|. . |||
ggvdleeavkelreqRpgavqtpsqyrflyealle
DSPc_SM00195 4068-4300 5.1e-67 221.3 In-house 37-262 (263) alignment 
Range on Protein: 4068-4300
Range on HMM: 37-262/263.0
ANDDTLVHLQDEQ----NSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETgeYDALVFGDLKISL
 .|.| |.|..|.    ..|||||....|.. ..  |||.||||| || ||||||||....|.||.| |.| || ||.|||| |    .  .||.... |
pydhtrVklkkeekkegsdYINAnyikgankkkk..yIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees..ggketfgkisvkl

VKSVSSG-NYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLmgvavnnpPWPTVVHCSAGVGRTGVLMLVESELIRLEQ
|.  .   ....| |....  ..  |.| ..||..||||.||....|.|... .... . .           |.||||||||||||....... | .||.
vevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts........sgpivVhCsaGvgRtgtfvtidiilsklee

GMRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVA
. ...  ... |||.||...|||.||| |. ...||..
ekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 4068-4300 5.1e-67 221.3 In-house 37-262 (263) alignment 
Range on Protein: 4068-4300
Range on HMM: 37-262/263.0
ANDDTLVHLQDEQ----NSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETgeYDALVFGDLKISL
 .|.| |.|..|.    ..|||||....|.. ..  |||.||||| || ||||||||....|.||.| |.| || ||.|||| |    .  .||.... |
pydhtrVklkkeekkegsdYINAnyikgankkkk..yIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees..ggketfgkisvkl

VKSVSSG-NYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLmgvavnnpPWPTVVHCSAGVGRTGVLMLVESELIRLEQ
|.  .   ....| |....  ..  |.| ..||..||||.||....|.|... .... . .           |.||||||||||||....... | .||.
vevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts........sgpivVhCsaGvgRtgtfvtidiilsklee

GMRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVA
. ...  ... |||.||...|||.||| |. ...||..
ekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0042113 (Phosphotyrosine protein) phosphatases II 4068-4298 1.3e-65 216.5 In-house 20-241 (245) alignment 
Range on Protein: 4068-4298
Range on HMM: 20-241/245.0
ANDDTLVHLQDEQ----NSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTetgeYDALVFGDLKISL
..|.|.|.|....    ..||||..|.. .  ..  .||.|||||.||.|||||.||.|....||.| |.| |.|||..|||.     . |..||... |
pydhtrvklspdggdldsdyinasyvdgyritpk..fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl....gesltygdftvtl

VKSVSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQG
..  . ..||.| |.| |. .|  |.|.|..|. ||||.|| ....||||....|... .       ... |..|||||||||||.....   | .||  
lseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.......dsngpvlVHCsaGvgRtGtfiaaylmleqleke

MRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLE
.. .. ... |||.|| ..|||..||.|. . |||
lgvsleeavkelrsqRpgavqtpsqyrflyealle
0040439 (Phosphotyrosine protein) phosphatases II 4068-4299 7e-65 214.4 In-house 22-245 (249) alignment 
Range on Protein: 4068-4299
Range on HMM: 22-245/249.0
ANDDTLVHLQD----EQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTetgeYDALVFGDLKISL
..| . |.|..    . ..||||.....   .|.  .||.|||||.||.|||||.||.|....||.| .|| |..||..|||.     . |..||... |
pydhsrvklsilpglflsdyinAsyidgyyikrr..fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl....ggsleygdftvtl

VKSVSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQG
..  ....||.| |.. |. ..  |||.|.||| ||||.||.....|||||...|... .|      ... |..|||||||||||.. .    | .||  
lsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel......pkggpvlVHCsaGvgRtGtfiaaylmleqleke

MRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEV
 . .. ... .||.|| ..||..|||.|... ||| 
lgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 4068-4297 1.2e-46 153.9 In-house 44-292 (297) alignment 
Range on Protein: 4068-4297
Range on HMM: 44-292/297.0
ANDDTLVHLQD--EQNSYINANHVTFAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLVK
| ||| |.|.    .. ||||..|.| .|   | || |||||  || |||..|.||. ...|||.   |.|. ||  |||   .|   |  ||. .  . 
atddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe..rlkagdvvvefls

SVSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDF-----------------IDEI-REIRVRLMGVAVNNP-PWPTVVHCSAGVGR
|.|    ..    .. .  .  | | | |. .|||| ||     |  |                 .. .   . ..|  .  . | . ...|||||||||
stsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGr

TGVLMLVESELIRLEQGMRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLL
.||..| .  | .| ..  |. .  |  ||||||..||| ||.|..    |
sGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 4068-4301 1.1e-35 117.7 In-house 67-284 (290) alignment 
Range on Protein: 4068-4301
Range on HMM: 67-284/290.0
ANDDTLVHLQDEQ-NSYINANHVtfaeEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLVKS
 || | | |.| .   |. ||.|    .|    .| .||.|  || |.|||| ...   .||.   .| || |||.|.| . ||  .| ||.. .   ..
cndktrvilkdGydGdyvhanyv....kGlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGe..vltfGeitvlcsee

VSSGNYTI-RGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIrvrlmgvavnnpPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMR
 .  . .| . | ||.. .     . ||.  .|||.||...  .||  .  .|..            . | |||||||.|||| .. .|  |  | .|  
ddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka............sGpvvvhcsaGiGrtGtfvaievglqilldGke

PNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVAR
 .. ..   ||. |.. || . ||   .. ||.. .
ldlldlvralrnsrlnsvqvdiqylalveilldlGk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 4068-4301 6e-34 112.2 In-house 44-267 (283) alignment 
Range on Protein: 4068-4301
Range on HMM: 44-267/283.0
ANDDTLVHLQDEQNSYINANHVTFA-EEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEyDalvFGDLKISLVKS
. |   |.|. | ..|||| ... . .. .   ||.||.||  || |||.||...    .||.|   |. ..|| .||| .  | |   .|.. ..| | 
padqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGse.d...yGeftvtlrke

VSSGNYTIRGLRVRNM---SEDLMrtVWHLQYTAWpdhsVPKTPSSLLDFIDEIREIrvrlMGVAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQG
..|  ..|. | .|.     . |.  . | |.  |    .   . . .. .  .  .    .    ...  | |||||.|.|||.|.. . . .  .   
ttsnsfiikelllrvnssakstll..lahyqvidW....leygeqaiinslvkfnkv....islqteskkgPivvhCstgiGrtavfiaasasvkdalte

MRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVAR
   .  ...  .||||  .||| .|| .     || | 
svvdvfavvkimreqrmmavqtldqyklvhelvleqal
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 4068-4299 9.9e-32 104.8 In-house 66-288 (305) alignment 
Range on Protein: 4068-4299
Range on HMM: 66-288/305.0
ANDDTLVHLQDE-QNSYINANHVTFAEEGrTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDALVFGDL--KISLV
..| ..|.|..     || ||.|          .|.|||||  |. .|| || ..  . .||.   || ||.|| .|||.  ||   |  | .  ..|  
cqdqsavkldkpspsdyihanyvgcpmip.ekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgs

KSVSS-GNYTIRGLRVRNmSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVrlmgvavnnppwPTVVHCSAGVGRTGVLMLVESELIRLEQG
| .    .  |  |..   | |   .| |||.| |||  ||    . |...  ||  .|            | |||||||.|||| .. .|  | .. . 
kpmerdaeiqitllnlty.sgdqkmsvrhlqwtewpdrgvppckltslellsairgskv............pivvhcsagigrtgtivaieyilekiaen

MRPNPRQTLV-ELREQRAKVVQTEEQYEFCLRTLLEV
 .  |   ||  ||.|||  .|.. || |  | .|. 
kpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 4068-4299 8.8e-28 92.1 In-house 54-270 (288) alignment 
Range on Protein: 4068-4299
Range on HMM: 54-270/288.0
ANDDTLVHLQDEQNSYINANHVTFAEEGRTLwyIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLVKSV
  | | |.|.|. . ||.|| |. |.  | |  | || || ||.. .|.|. |.. . .||..  .| || | . |.|.. ||  .  .| |     |. 
rcditrvklsddpdfyiaanvvssakykrrl..icaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGe..karigrlctvvkkkr

SSGNYTIRGLRVRNMSEDLMRT-VWHLQYTAWPDHSVPKTPSSLLDFIDEIreirvrlmgvavNNPPWPTVVHCSAGVGRTGVLM--LVESELIRLEQGM
.  . ...   .|.  |   .  | .| .  |.|..||.   | | ... .            ..   | |||.|||||||| |.  |.  | .||.  .
adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl............kslqkPivvhssaGvGrtgtlililialeslrlddfl

rpNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEV
    |. | .|||.| | .||| || .  | .|| 
..girsllaklreerfkaiqtemqylyvhrcvlee
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 4068-4307 2.6e-19 63.8 In-house 62-292 (302) alignment 
Range on Protein: 4068-4307
Range on HMM: 62-292/302.0
ANDDTLVHLQDEQNSYINANHVTFAEEGRTLwyIAAQGPLPGTV---GDFWRMVWEQGSQIVVMVTGEVEGGKvKCERYWPTETGEYDAlvFGDLKISLV
. |..|| |. |..||.|| .|.  | .|..  | || |  ...    .|||||...  . ||.. || |  |   . ..|...|.|    .|.. .   
ildsnlvkleaepdsyvnaskvevPeltrsi..ilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdyke..ygkmfvNnr

KsVSSG-----NYTIRGLrVRNMSEDLMRTVWHLQYtaWPDHSVPktpSSLLDFIDEIREIrvRLMGVAVNNppwPTVVHCSAGVGRTGVLMLVESELIR
| |..      .|.|  |   ..|. .. .| .|..  |....||    .  . | .. ..      . ...   .||.    |.|| |... .   . .
k.VekaeeektryviEvl.Pegcsnsvlanvyvltn..Wkqkkvp...vkyaeliktaakv..fakkikade...ntvivSknGaGRagafltlavavek

LEQGMRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKRQTAE
|..|  ||  ...  .|.||...|.. .|| .  ..||   .|. | .
lqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkp
subfamily_PTPN3_pd Subfamily PTPN3 4069-4301 7.8e-69 226.7 In-house 53-276 (280) alignment 
Range on Protein: 4069-4301
Range on HMM: 53-276/280.0
NDDTLVHLQDEQNSYINANHVTFAEEGRTLW--YIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETgeyDALVFGDLKISLVKS
 |.| |.|..... |||||.| .  .. .|   |||.||||. |. |||.||||| |...||.|  || |.||| .|||...   | | .|.... . |.
ydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPete...deleygefsvkceke

VSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRvrlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRP
 .. .| .| | ... ...  |.. .|||.|||||.||. ....|.|....|..|        .    |.|||||||.||||||.|.|  |  .|.    
detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr........sgkeePvvvhCsaGigrtGvlilletalalieaaepv

NPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVAR
.| . . ..|.||| .|||..||.|   ..|.| .
ypldivrtmrdqramlvqtasqykfvCeailkvye
Y_phosphatase Protein-tyrosine phosphatase 4069-4298 9.4e-66 216.9 Pfam-A 13-235 (235) alignment 
Range on Protein: 4069-4298
Range on HMM: 13-235/235.0
NDDTLVHL--QDEQNSYINANHVTFAEEgrTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLV-K
 |.| |.|  ..... |||||.|.  .|  .  .||.||||. |..|||||||.. ....||.| ..| |..||..|||.|..|   | .||.|. |. |
ydktrvklkgsegpsdYInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee..sltygdikvelkek

SV-SSGNYTIRGLRVRNMSED-LMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRvrlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQG
.   . .||.| |....  |.   |.|..|.||.||||.||..|.||||.|..... .        ..   |.||||||||||||......  | .||..
ekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk........eaksgpvvVhCsaGvgRtgtfvaldilleqleae

MRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLE
  ..  |.. |||.||...||..|||.|. ...||
eevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 4069-4298 9.4e-66 216.9 In-house 13-235 (235) alignment 
Range on Protein: 4069-4298
Range on HMM: 13-235/235.0
NDDTLVHL--QDEQNSYINANHVTFAEEgrTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLV-K
 |.| |.|  ..... |||||.|.  .|  .  .||.||||. |..|||||||.. ....||.| ..| |..||..|||.|..|   | .||.|. |. |
ydktrvklkgsegpsdYInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee..sltygdikvelkek

SV-SSGNYTIRGLRVRNMSED-LMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRvrlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQG
.   . .||.| |....  |.   |.|..|.||.||||.||..|.||||.|..... .        ..   |.||||||||||||......  | .||..
ekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk........eaksgpvvVhCsaGvgRtgtfvaldilleqleae

MRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLE
  ..  |.. |||.||...||..|||.|. ...||
eevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_PTPN23_pd Subfamily PTPN23 4069-4303 6.2e-57 187.6 In-house 55-283 (288) alignment 
Range on Protein: 4069-4303
Range on HMM: 55-283/288.0
NDDTLVHLQDEQNSYINANHVTFAEEGrTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLVKSVS
 | . |.|..... |||| .|     | .  .||.|.||..|..|||.||.|| |...||.. . | || |..||||...||  . .||||...| .  .
yDhnRvklrgskDDYinAsfvkdlspg.cPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkge..tvkfgdlsvtlksvre

SGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGV--AvnnppwPTVVHCSAGVGRTGVLMLVESELIRLEQGM-R
....  | |...  ..| ...| |||.|.||.. ||..|..||.|.||...          .      | |||||||||||||. || . .. ||.|   
tethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt......PlvvhCsaGvgRtgvfalvyaavrelekgngl

PNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKR
..  | .  |||||  .||..||..|..   || ||. 
ldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrv
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 4069-4299 1.7e-38 127.2 In-house 59-277 (287) alignment 
Range on Protein: 4069-4299
Range on HMM: 59-277/287.0
NDDTLVHLQDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGeydaLVFGDLKISLVKSVS
 |.  | |..|.. |||| ..   .| .   .|.|..|.  |. .||......  ...||.. | |  . .| .|||.|.     .|.|. .|.|..   
pdnyrvllkgehpdyinavfidgykekka..fiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks....vvlGeyniellneev

SGNYTIRGLRVRNMS-EDLMRTVWHLQYTAWPDHS-VPKTPSSLLDFIDEIREIRVRLMGvavnnppwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRP
. .|..| |.|.| . ..  ..|   |.|.|...  |..  ..|| . . ... | |  .        . |||||..|||..... ..  . . ..    
nagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgnt........sivvhCsdtvGrsamfcaaattinkckteGvi

NPRQTLVELREQRAKVVQTEEQYEFCLRTLLEV
.  | | . | |. . ||| |||.|    .|| 
Dvfqvlksqriqkpgsvqtveqykfindivley
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 4069-4303 3.3e-25 83.6 In-house 45-262 (267) alignment 
Range on Protein: 4069-4303
Range on HMM: 45-262/267.0
NDDTLVHLQDEQNSYINANHVTFAEEGRtlWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGgkvKCERYWPTETGEydALVFGDLKISLVKSVS
 ||| | |..... |||| .|   . ..  ..|. |.||  |..||. .. .|.  ..|..|   ..   .  ..|| . |.  |  . || .       
yddtrvilrtkeeeyinasyvegyktkn..afivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPPkmgq..akkyqdltvehsleke

SGNYTIRGLRVRNMSEDlMRTVWHLQYTAWPDHSVPKtPsslldFIDEIREIrvrLMGVAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNP
  .| |  | ..   |   . |    |  |   .  | |     ..  .  |   |    ..|   | ||.||.||||.| .. ..| | |. .    . 
endyqiitlelkfknes.ahnvtlyyykkwnintnnk.p.....ylkplfgi...laknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdi

RQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKR
 . | ..|.||  .|.| |.| .. ..| | |. |
fdflrkirsqriglvdtkeryiyihellaeyaegr
subfamily_eak_pd Subfamily eak 4069-4304 2e-18 60.9 In-house 66-309 (332) alignment 
Range on Protein: 4069-4304
Range on HMM: 66-309/332.0
NDDTLVHLQDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGeyDALVFGDLKISLVKSVS
.   |   | ... ||||  . |.| ||   || .  .    |  ||.|| || |  .|..  .|| .  | ..|.| .|   . | || |..   . | 
ylvrltssqlnrlGyinaslaefsevGrk..yiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktr..eelkfGildverkefvk

SGNYTIRGLRVRNMSEdlMRTVWHLQYTAWPDHSVPKTpSSLLDFIDEIREIRVRLMGVAVNN-------------PPWPTVVHCSAGVGRTGVLMLVEs
 ...  | | ..   |     | | ..  | . ..||    .| . . ..|. | |. |  ..             |    .. .. |  |.||..... 
rniletrllelskGne..thrvlhykvfGwtettlpky.edflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsaraGvfvvid.

ELIRLEQGMRPNP---RQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKRQ
 |||| .. . |     . ..  ...| . | .. |. |    .|.  ..|.
llirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn
subfamily_PTPN13_pd Subfamily PTPN13 4070-4300 2.3e-65 215.6 In-house 50-269 (273) alignment 
Range on Protein: 4070-4300
Range on HMM: 50-269/273.0
DDTLVHLQDEQNsYINANHVTFAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEyDALVFGDLKISLVKSVSS
|.| |.|.|| . ||||...    .  .  |||.||||| || |||.||||| .....||| |.|.|||||.|||| ....    | . |...|.| .  
detrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknk.klkvsnrlevellkvqkl

GNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMgvavnnppwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPR
 ....| | |...     | | ||....||||.||... .|| |. |.|...             | |||||||.||.|.|. ..  |  .|.    . .
dgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdag.........PivvhcsaGiGrsGtlitidvvlglierdkefdvk

QTLVELREQRAKVVQTEEQYEFCLRTLLEVA
... .|||||  ||||..|| |. ...||| 
eivrklreqrqgvvqtkdqyifvykailevl
subfamily_PTPN6_pd Subfamily PTPN6 4070-4305 2.5e-62 205.6 In-house 67-302 (306) alignment 
Range on Protein: 4070-4305
Range on HMM: 67-302/306.0
DDTLVHLQDE---QNSYINANHVTFAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDalvFGDLKISLVKS
|.| | |...   .. ||||| .. . .| .  |||.|| |. || |||||||.. |...||.| ||| || || ||||.|. . .   .|..... |..
DhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee...yGkisvtnvse

VSSGNYTIRGLRVR-NMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLE-QG-
 |  .|..| |.|  . ...  |.|.......||||.||| |. .|||...... . .|.    .. . |.|||||||.|||| .....  |  .| .| 
ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeele....eaeagpivvhCsaGiGRtGtfiviDillkliekkgl

-MRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKRQT
 .  . ...   .||||  .||||.|| |  ... .  .....
dadidiqklvksvreqrsglvqteqqykfvykaikkyietkkk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 4070-4302 7.1e-58 190.9 In-house 54-278 (281) alignment 
Range on Protein: 4070-4302
Range on HMM: 54-278/281.0
DDTLVHL----QDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGeydALVFGDLKISLVK
| | |..    ..... |||||.|   .. .   |||.|||.| .. .||.|||||  ...|||| |.|.||.|| |||| ..    .| .||.... ..
DatrvkvtpneenkntDYinanfvpgykgeke..yiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddns...elkygdvtvksta

SVSSGNYTIRGLRVrNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGvavnnppWPTVVHCSAGVGRTGVLMLVESELIRLEQG-M
. .. .|  | ... ....   |.| .|.||||||| ||.|.. ||.| .|..... .           | |.||||||||||. . ..  . ..|.   
eeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk.......aplvihCsaGvGrtGtyialDrlvkaveaele

RPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVARK
. ...... |||..|  .|||  ||||  ...|..  |
eldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_PTPN1_pd Subfamily PTPN1 4070-4301 1.3e-56 186.5 In-house 45-272 (290) alignment 
Range on Protein: 4070-4301
Range on HMM: 45-272/290.0
DDTLVHLQDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGeYDALVFG--DLKISLVKSV
| . ..|....| ||||. | . |  |   || .||||| ||. ||.||||| |. |||.   || ...|| .|||..    ..|..    ||. |..  
dhsrikleradndyinaslveleeakrs..yiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee.ekellledtklkvklisee

SSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREirvrlMGVaVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMR--
.. .||.| |.. |.. .  |.. |  ||.||| .||..|...|.|. ..||      |. ...   |.|.|||||.||.| ..||.. |...|.     
rksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvre.....sGs.lssdvGpavihcsaGiGrsGtfclvdtclvliekkddls

-PNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVAR
  . ...|.|||..|  ..|| .| .|   ..|| |.
svdikkvllelrkyrlGliqtadqlrfsylaileGak
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 4070-4307 3.4e-55 182.1 In-house 60-286 (288) alignment 
Range on Protein: 4070-4307
Range on HMM: 60-286/288.0
DDTLVHLQD----EQNSYINANHVtfAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETgeyDALVFGDLKISLVK
| . |.|..    ... ||||...  ..|...  |||.||||. ||.|||..|.|. .. .||.|. ||||| |||.|||..    .   .|.... ||.
DekrvklkkleeeagaDYinasyi..dgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdad...kpknyGsvtvtlve

SVSSGNYTIRGLRVRnmSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLmgvavnnpPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMR
|   .... | | .    .   ... ..||.|||||.||.    ||.... .                 | .|||||||||||. . ..  . ..|.   
skeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad........tgpiivhCsaGvGrtgtFialdalidaveeedy

PNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKRQTAE
 .   |. .||.||| .|||..||||. ..||... ..  ||
iDvagtvaklRkqRallvqtlkqYefiyevllslieedgvae
subfamily_PTPRN_pd Subfamily PTPRN 4070-4297 5e-44 145.2 In-house 69-289 (297) alignment 
Range on Protein: 4070-4297
Range on HMM: 69-289/297.0
DDTLVHLQ----DEQNSYINANHVTfAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydalVFGDLKISLVK
|.. |.|.    .|.. ||||  ..  .. |.  |||.||||. || |||.||||||. ..|..|   | |  .|.|||| |  |    |..  .. || 
dhsrvklkeeasaeksdyinasail.dhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGse....vyhiyevhlvs

-SVSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIdeiREIRVRLMGVAVnnppwPTVVHCSAGVGRTGVLMLVESELIRLEQGM
  . . .| .| . ..|.  .  |||  . . .||...|| .. |||.|    | .     | .      | |||||.|.||||| .|..  | || .|.
ehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefr...rkvnksyrGrsc.....pivvhcsdGaGrtGvyilidlvlnrllkGv

RPN-PRQTLVELREQRAKVVQTEEQYEFCLRTLL
.      ||  ||.||...|.|..|.||.| .. 
keidiaatlehlrdqrpglvktkdqfefaltava
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 4070-4296 1.1e-42 140.9 In-house 51-273 (287) alignment 
Range on Protein: 4070-4296
Range on HMM: 51-273/287.0
DDT---LVHLQDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgEYDALVFGDLKISLVKS
|||   |..  .   .|||||.|.  ..  .  .||||||.. ||.||||.|.|. |  |...| ||| .. || .|||    |   .| |   . | ..
ddtrvllsaegelGsdyinanyvasytddea..fiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer..evPmrvGGysvvlldyd

VSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEI-REIRVRLMGVAVNnppwPTVVHCSAGVGRTGVLMLVESELIRLEQGMR
. . .|..| ||. ..     | |  |.. .|||.... |  .|. |. .. . | ..  .  |     | |||...|.||.|.|. .   . |||.  |
ikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevG....PlvvhddvGiGrsGillatlvlvsrledlGr

PNPRQTLVELREQRAKVVQTEEQYEFCLRTL
 .. .... |||.|| .||.  |. .   .|
vdvaavvirlreyraalvqavvqlrllyeal
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 4070-4298 5.1e-23 76.4 In-house 48-268 (285) alignment 
Range on Protein: 4070-4298
Range on HMM: 48-268/285.0
DDTLVHLQDEQNSYINANHVTFAEEGRTlWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLVKS--V
..| | |.. .  || |. . .  . ..  ||..||||| |. |||.|....    |.|.   .|||  ||  |.| . ||   . ||  .|.| .    
eetrvvlknhdrdyihaswmrmpgkdqs.tyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge..vvkfgkyeitlteckee

SSGNYTIRGLRVRNMSEDLMRT--VWHLQYTAWPDHSVPKTPSSLLDFIDEIREirvrlmgvaVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMR
.     .  | | |  .       . |.|   |||.  |.    ....   ...         ||    | .||||||||||  .. ..   ||. .   
aiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.........vnpkekpicvhcsagvgrtatfvgidyatirimenpn

PNPRQTLVELREQRAKVVQTEEQYEFCLRTLLE
 .  . . |.|  | . ||.  |. |    |.|
iemldivremramrfqavqshmqflflyvvlme
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 4070-4293 1e-13 45.6 In-house 60-272 (303) alignment 
Range on Protein: 4070-4293
Range on HMM: 60-272/303.0
DDTLVHLQDeqNSYINANHVTFAEEGRTlwyIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgeYDALVFGDLKISL--VKSV
| . |.| |   ||| |... .  . ..   | .| ||. |  |||.|. ||  . |...  . |  |.  .  .| .    | | | .  | .   | |
dhskvklsd..ssyihasyleldsskka...iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn...qdflkfeersirvgefkrv

SSGNytIRGLRVRNMSEDLMRTVWHL-QYTAWPDHSVPKTPSSllDFIDEIREIRVRLMGVAvnnPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGM-R
  |.     |.|  .|.   ..  |. .| |||  |.|   |.   |. .| ...  |   .   .  |||    .|.||.| . | |.  . | .    
elgd..gwvlkvlsvsngdyksflhvhhykawphnsipsdgsp..kfvkqiwqlqsvlrkys...dstptvymslsgcgragtfalfetahlslhseqas

PNPRQTLVELREQRAKVVQTEEQYEFCL
 .  . |  .|. | . ||   |. .  
ldlvkclenvrngrlhavqnlsqfsvvy
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 4072-4299 1.7e-32 107.6 In-house 58-276 (307) alignment 
Range on Protein: 4072-4299
Range on HMM: 58-276/307.0
TLVHLQDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDALVFGDLKISL----VKSV
 .|...     || ||..  | . .   .|.|||||  |. .|| |. ..  . |.|.   .| .|.|||.||| | |.  . .     ||.    .| .
ivvkfdglasdyihanylgiaikpkk..ficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakkl

SSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDeireirvrlmgvAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPN
.  .  |    ..    .  ||. |||.. |||. ||..  . .....            ||.    | ||||||||||.| .. .     .. .|.   
apdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlle............avrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinck

PRQTLV-ELREQRAKVVQTEEQYEFCLRTLLEV
  . || |||.||   .||| || .  | ||| 
dmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_PTPN14_pd Subfamily PTPN14 4073-4298 1.2e-64 213.2 In-house 68-294 (300) alignment 
Range on Protein: 4073-4298
Range on HMM: 68-294/300.0
LVHLQDEQNSYINANHVTFAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDALVFGDLKISLVKSVSSGNY
|.  ..... |||| ..  .  |... ||.|||||. || |||.|||||| |..||.| | |.|| |. .|.| .. . . . ||  |..   | .|. .
lsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsv

TIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGVA-VNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQT
. .||... .     ||||||||| |||| ||. ... |....|.. .| .       ..   | .|||||||||||||.|..  .  ||.. . . ...
ittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkv

LVELREQRAKVVQTEEQYEFCLRTLLE
|  |||||  .|||  ||.|  ..|..
larLreqrmllvqtlaqYkfvYkvlik
subfamily_PTPRB_pd Subfamily PTPRB 4073-4306 6.9e-63 207.4 In-house 67-291 (293) alignment 
Range on Protein: 4073-4306
Range on HMM: 67-291/293.0
LVHL----QDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgeYDALVFGDLKISLVKSVS
 |.|    ..... |||||..   .  |   .||.|||||.|| ||||||||. |.|.||.|  ||.||||||.|||..   ... ..||.|..||.. .
rvkLaalkdesgsDYinanyipgynspre..fiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad...eepvlyGdikvtlvaeee

SGNYTIRGLRVRNmsEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNP
  ...|| |....  |. .|.| ....|.|||| ||.....||||. ..||   .      ..   |.||||||||||||... ..  | ..|.    . 
ledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiek......taskrPivvhCsaGvGRtGtfialdrllqaieeedyvdi

RQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKRQTA
  ...||||.|. .||||.|| |  ...|.. ||....
fgivaelReeRnllvqtekqYifihqcvldllrkkeee
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 4073-4302 6.3e-62 204.5 In-house 62-282 (318) alignment 
Range on Protein: 4073-4302
Range on HMM: 62-282/318.0
LVHLQ----DEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgeyDALVFGDLKISLVKSVS
 |.||    .|.  |||||..   .. ..  |||||.||| |. |||||||||.|...||.| |.| ||.|..|||| .    ..  .|.|.. | ..|.
rvkLqmlegeegsDyinanyidGyrrkka..yiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk....gsrsygklvvelkeeve

SGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNP
...|..| ..|..  |.  |.|   .||.|||..||. ..||||.. .....  .       .   |.||||||||||||| . |.. | |...    . 
lsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqk.......sgagpivvhCsaGvGrtGvfiavdillerikaealvDv

RQTLVELREQRAKVVQTEEQYEFCLRTLLEVARK
 ||  .|||||  .||||.||||.  .|||    
fqtvkqlreqrnlmvqtedqyefiydvllealas
subfamily_PTPRK_pd Subfamily PTPRK 4073-4301 9e-48 157.7 In-house 62-278 (314) alignment 
Range on Protein: 4073-4301
Range on HMM: 62-278/314.0
LVHLQDE-QNSYINANHVtfAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYdalvfGDLKISLVKSVSSGN
|. .... .. ||||. .      |.  .|..||||. || ||||.|.....  .||.|  || |.||| .||| .|  |     ||.|. ||..    .
litidgdpssdyinaali..dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevy.....gdikvelvetellae

YTIRGLRVRN--MSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvavnnPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPR
. .| .||..   . . .|.| ..|...|||| ||.   .||... .. . .             ..||||||| ||||. . ... |  .|.    .  
lvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee........eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvf

QTLVELREQRAKVVQTEEQYEFCLRTLLEVAR
..  .||...  .|.||||| |.   .|| . 
navktlrsrkvnmveteeqykfiydvileacl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 4073-4300 2.5e-41 136.9 In-house 67-288 (325) alignment 
Range on Protein: 4073-4300
Range on HMM: 67-288/325.0
LVHLQD-EQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMV--WEqgsQIVVMVTGEVEGGKVKCERYWPTETGeyDALVFGDLKISLVKSVSS
|. ..|  .  ||||...    .  .  ..||| ||. |..|.||.|  |.     ||.|. |...|| .|  ||| | |  ..  || |...|.     
letkkddpssdyinasylrddkkkdv..flaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavywpkemg..ksktfGglevklrtieei

GNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGVavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPR
 .|  | | |.....   |.|  .|. .|.|  |.| |..|. ... . ..  |.      .   | .||||||||||||.. . | | .. .  | .  
sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtan..tkastpilvhcsaGvGrtGvfislysalakvieesrvdif

QTLVELREQRAKVVQTEEQYEFCLRTLLEVA
. .  ||..| ..|.| .|| ..  .| |. 
gfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 4073-4293 5.7e-13 43.0 In-house 53-281 (302) alignment 
Range on Protein: 4073-4293
Range on HMM: 53-281/302.0
LVHLQDEQNSYINANHVTFAEegrtLWYIAAQGPLPG-----------------TVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALV
. .|.| .| .|||| ... |    . .| ||||. |                 |.  .| .. .    ||| ... ||... ||  |. .. |.   | 
maklvdfkndfinanvlklde....ikwimaqGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvgg..elk

FG-------DLKISLVKSVSSGNYTIRGLRVRNM--SEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLmgvavnnppwptVVHCSAGVGR
||       ..|  | .     ....  . ..|    ... .||  |...|||||  || . . || .      .  .            .|||||||||
fgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesykknv............lvhcsaGvGr

TGVLMLVESELIRLEQGMRPNPRQTLVELREQRAKVVQTEEQYEFCL
|| |. .   .    .    .  . .. .|. |   ||.|.|  . |
tGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 4074-4300 3.6e-27 89.9 In-house 60-276 (312) alignment 
Range on Protein: 4074-4300
Range on HMM: 60-276/312.0
VHLQDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEY---DALVFGDLKISL-VKSVSS
  |  ..| || || |          ....||||  |.  ||...   ||  .....| || |  || .|     |     |  |. .    . .   | 
ftlagdenfyihanfvkictkper..fvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggksk

GNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPktpssllDFIDeireIRVRLMgVAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPR
 . | | |.|   .      . | |...|||| .|       |  |       ||.  ||..   | . |||||||||| |.|.|| .  | .  . | .
dkithrvlkvvvkatgqesklnhyqwaswpdhgmp.......dscd....talrll.savkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvk

QTLVELREQRAKVVQTEEQYEFCLRTLLEVA
...| || .||. |..  || ..||..||. 
dsfvllrkdrarsvrvfpqyvyalrcvlefl
subfamily_ptpA1_pd Subfamily ptpA1 4075-4251 5.5e-32 106.0 In-house 68-247 (418) alignment 
Range on Protein: 4075-4251
Range on HMM: 68-247/418.0
HLQDE-QNSYINANHVTFAEEGRtlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEY-------DALVFGDLKISLVKS
..||.  . |||||..  |   .   .|..||||| |. ||||||||.  .|.||.. | |  ..||.|||| . |            |||   . ||. 
kiqdkegsdyinanyidgaypkq...fictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelvev

VSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGVAVNNppWPTVVHCSAGVGRTGVLM
.   .  |    .|   |   | . . ||  |||| .|     . ...  | . . ...  .  |   | .||||||||||| . 
iqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrn..vpiivhcsagvgrtgtfc
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 4075-4292 2e-30 100.5 In-house 64-285 (301) alignment 
Range on Protein: 4075-4292
Range on HMM: 64-285/301.0
HLQDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDAlvFGDLKISLVKSVSSGNYTI
.|.  |..||||...    | .   .||||||.  |. ||||..|..  . .||||.. || | |||.|||. . | .   || ... ||..    ...|
nldlcqreyinasyidgysekkk..fiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaesee..fgpftvtlvneqvyPdfvi

RGLRVR--NM-------------SEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGVavnnppwPTVVHCSAGVGRTGVLMLVEselIR
| | |.  .              |.   ..|  || | ||.. | . |   |  ||..   . .  |        | |||||..|.|.|| . |.   | 
rqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkiggg.......pvvVHCSdtVsrsGvYcsvs...ig

LEQGMRP---NPRQTLVELREQRAKVVQTEEQYEFC
|||  .    .  |    .| .. ..|.| ||| . 
lEQckaegVVdvfqvtkavrrskpgaVtTLeqytsi
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 4076-4302 3.5e-55 182.0 In-house 52-270 (274) alignment 
Range on Protein: 4076-4302
Range on HMM: 52-270/274.0
LQDEQNSYINANHVTFAEeGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDALVFGDLKISLVKSVSSGNYTIR
 .||. ||||||..   . ...  |.|.||||| || |||||.... .|..||.|   |  . ||..|.|....   .  .||..|  .| |.  .|..|
sededssyinanyikGyd.eeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvr

GLRVRNMSEdlMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvaVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVEL
 | ......   |.| |  ||.|||| .|. ...|||...|..| | .      |..  |.|||||||.||||. . ..  . .|.. .  .  .. ..|
klvlkyler..ersvkhywytdWPdhksPddantlldlvleveesree.....enaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnl

REQRAKVVQTEEQYEFCLRTLLEVARK
| .|  .|||.||||.  |.| . ...
rldrGGmvqtseqyelihralclylkr
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 4076-4299 1e-52 174.2 In-house 67-282 (305) alignment 
Range on Protein: 4076-4299
Range on HMM: 67-282/305.0
LQ--DEQNSYINANHVTFAEegRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDAlvFGDLKISLVKSVSSGNYT
 .  .... ||||..|   .  |   ||.|||||. || ||||...|   . .||.|. ||||| ||..|||....|     ||.... |  . .  .|.
ekeslddsdyinasyvdgyk..rkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekke..fgefsvelksektasdyi

IRGLRVRN-MSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGVAVnnppwptVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTL
.| |.. .  ...  ||| ..| | |||| ||....|||..|..... . .  ||..       .|||||||||||| . |.  | ||..    .  . |
eRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpl.......lVhCsagvgRtGvfiavdialerlkkEevvdvfevl

VELREQRAKVVQTEEQYEFCLRTLLEV
 .||..| |.||| .|| |.   | | 
kqlRskrmkmvqtldqYvflhdaldel
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 4076-4302 2e-41 137.0 In-house 73-286 (297) alignment 
Range on Protein: 4076-4302
Range on HMM: 73-286/297.0
LQDE-QNSYINANHVTFAEEgrtlWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKvKCERYWPTETGEYdalvFGDLKISLVKSVSSGNYTI
..|. .  |.|| .|   ..     .|. | | . || |||.||...  ...||.. . |. | || |||. ..       |||. . |    .   .  
vnddpdsDyvnasfvkgnkh....rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt....fGdvsvvllsvsereGfik

RGLRVRNMSEDLMRTVWHLQYTAWPDHSVPK--TPSSLLDFIDEIREIRvrlMGvaVNNPpwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTL
| | |.. .    | |   |.. |||..|..  . ||||..|.|.|.      .  ...   | .|||.|||||||||. ..| . . ..    .  ...
relevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdf...sq..naeg..PllvhclaGvGrtgvlltidsvvaeakrekevdifglv

VELREQRAKVVQTEEQYEFCLRTLLEVARK
  ||..| ..|||.|||.|   ..||.   
kklrqerpylvqtkeqykfvyvavlealls
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 4076-4301 9.3e-41 134.6 In-house 65-284 (290) alignment 
Range on Protein: 4076-4301
Range on HMM: 65-284/290.0
L------QDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgEYDAlvFGDLKISLVKSVSS
|      .| .|.|||| ..   .| .   |||.|||.. |. |||...|.. . |.||.| ..| |||||  |||..  . .|  .|  .| |..  . 
LrpisghkDCtneyinAcyikgykekkq..yiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtka..ygefsikllneetl

GNYTIRGLRVRNMSE-DLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlMGvavNNppwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNP
 .|..| |.|.|... .  ..| ..| |.|...   . |.. |  | |. ... .  |   |.   . |||||..|||..|.. ..  . . ..    . 
neyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrk.rg...nt...sivvHCSdtvgrsavfcaaattinkcktegvidv

RQTLVELREQRAKVVQTEEQYEFCLRTLLEVAR
 | | ..| |. . |||..||..  . .|.   
fqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_CG7180_pd Subfamily CG7180 4076-4299 3.9e-33 109.3 In-house 64-289 (296) alignment 
Range on Protein: 4076-4299
Range on HMM: 64-289/296.0
LQD-EQNSYINANHVTFAEegRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKvKCERYWPTETgeydALVFGDLKISLVKSVSSGNYTI
|.  |.. |||| .|      .   ||  ..|   ||..|||.|...... ||..| . .  | ..  ||| ..       .|.. . .|.. .  | .|
ldGeeksdYinavyvdsfl..kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks....keqygeifveiveekqyanlki

RGLRVRNM----------SEDLMRTVWHLQYTAWPD-HSVPKTPSSLLDFIDEIREIRVRLmgvAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQG
| ...  .           .   |.| ..|.| |.  ..||   ..|....  .| .| .      ..   |.||..| |..|.|| . ..  |  .|. 
rtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv...dedpeegPvvvvssdGasRsGvylaidanlelveke

MRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEV
 . .  . .  ||..| ..|.. |.| ..  .||| 
eevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_CG42327_pd Subfamily CG42327 4076-4219 6e-28 92.4 In-house 51-192 (319) alignment 
Range on Protein: 4076-4219
Range on HMM: 51-192/319.0
LQDEQNSYINANHVTFAEEGRTlWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDALVFGDLKISLVKSVSSGNYTIR
 .|... |..|..|   .. ..  ||||| .|  .  ||||.|||| |...| .|   | |  .| .|.||. .  .  ..||....| .  .  .| | 
gdddkdeyldasyvrGyddapn.syiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryais

GLRVRNMSEDLMRTVWHLQYtAWPDHSVPKTPSSLLDFIDEIRE
 | .... ... | . |  |  |..  ||  ...|.  . |.|.
tlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 4076-4289 8.4e-28 92.0 In-house 70-270 (301) alignment 
Range on Protein: 4076-4289
Range on HMM: 70-270/301.0
LQDEQNSYINANHVTFAeeGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDALVFGDLKISLVKSVSSGNYTIR
..| .   | || .     |..  .||.||||. |  ||| |.     . .||.. .||  . ||| | |....|   .   ..||   ... . . . |
ivdGkrvPihanwipts..GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskr

GLRVRNMSEDL-MRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREirvrlmgvavnnPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVE
 |.|.. ....  ||| | ||. |.|. |||.   | |... ...               | |||||||.||.  ..  |    ..|   . .  ..| .
tlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk............sekPivvhcsaGiGrsvafigteylareveadptieltealkh

LREQRAKVVQTEEQY
|||.| . |||..| 
lrehrwngvqtnsql
subfamily_PTPRD_pd Subfamily PTPRD 4077-4304 1.1e-69 230.6 In-house 72-285 (564) alignment 
Range on Protein: 4077-4304
Range on HMM: 72-285/564.0
QDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtGeydALVFGDLKISLVKSVSSGNYTIRG
.||.  ||||...   .. ..  |||.||||. |. ||||||||| |...||.|  .| |||||..|||.. |      .|.|...|....   .|.|| 
gdegsDYINAsfidgyrkrka..yIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g...tetygeltVtleeeeeladyeirt

LRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRvRlmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELR
..... ... .|.| . ..|.|||| ||... ||||.|...|... .       .   |.||||||||||||. . ... | |...    . .|.. .||
fklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e.......pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalr

EQRAKVVQTEEQYEFCLRTLLEVARKRQ
.||  .||||||| |. ...||   . .
kqRnamVqteeQYiFiheailealacgn
subfamily_PTPN9_pd Subfamily PTPN9 4077-4303 5.7e-62 204.4 In-house 66-293 (297) alignment 
Range on Protein: 4077-4303
Range on HMM: 66-293/297.0
QDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLVKSVSSGNYTIRG
.||.  |||||.|   .. ..  .||.||||. || |||||||||   ..||.|  || |..|| .|||.|...  .  ||||..| |. ... .|..| 
edeasdyinanfvdGykqkka..fiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees..saefgdlsvsnveveeeedykvrv

LRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIR---VRLMGVAVNNPP--WPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQT
| ..|. .. .|.| | |...|||. ||.. .||||.....|| .   |. .|   . .|   | |||||||.|||| .. ..  | |||.    . ..|
leiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvet

LVELREQRAKVVQTEEQYEFCLRTLLEVARKR
.  ||.|||  .||.||||||  ..|| | ..
vkllrtqrafsiqtpeqyefcylavleyalel
subfamily_PTPN12_pd Subfamily PTPN12 4077-4303 8.4e-59 193.8 In-house 64-280 (290) alignment 
Range on Protein: 4077-4303
Range on HMM: 64-280/290.0
QDEQNSYINANHVTFAEEgrTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLVKSVSSG-NYTIR
..|...|||||..  .|.  .| ||||||||| |. |||||.||.  .||||.  ||| || ||||||| |..|  .| ||.....| .      ...||
eeegsdYinanfikgveg..kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegee..elefgefevtleeekavdddflir

GLRVRNMSEdlMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVrlmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNP---RQTL
 |.|.. .|   |.|  ..||||||| ||....|||..|...||..         .   | ||||||||||||... ..     |.... |.     . .
tLkveaqke..srkvyqfhYtaWPDhgvPssaksllelielvrelqe........sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlv

VELREQRAKVVQTEEQYEFCLRTLLEVARKR
.|||.||| .|||.||||.  ....|. .|.
lelrkqraalvqtkeqyelvykavaelvqke
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 4077-4304 1.2e-56 186.7 In-house 44-268 (270) alignment 
Range on Protein: 4077-4304
Range on HMM: 44-268/270.0
QDEQNSYINANHVTFA-EEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDALVFGDLKISLVKSVSSGNYTIR
.|..  |||||.|  . .| ..  ||||.|||| |. .||||.||. .. .||.|| .| |. |||||||.|..|  .| .|..|.  .... .  | ..
edsataYinAnyvrGfdgekkk..YiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyilt

GLRVRNMSEDlMRTVwHLQYTAWPDHSVPKTPSSLL---DFIDEIREIRvrLMGVAVNNPPwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTL
 ||... .|   | | | .|..||||.||... | |   . .  .|..|   .    ..   |..|||||||||||.|....  .  ||. .. .. . .
rlrleekgee.rrlv.HfwyntWpdhgvpreedsslstdqllkmlravr..rsekeldkae.PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaii

VELREQRAKVVQTEEQYEFCLRTLLEVARKRQ
 |||..| ..||. |||||  ....| |..|.
eelRkdRmalvqhpeqyeflykavveyaerra
subfamily_Ptp69D_pd Subfamily Ptp69D 4077-4307 6.5e-55 181.4 In-house 72-293 (307) alignment 
Range on Protein: 4077-4307
Range on HMM: 72-293/307.0
QDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgeyDALVFGDLKISLVKSVSSGNYTIRG
 .|. .||||...   .| ..  .||||.|. .|.||||||..|| ....||.. . |  . ||..||| |    |   .||. . ||.. . ..|.|| 
gkedsdYinasfikgykekkk..fiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie....devqygdilvklvseekhsdyiiRe

LRVRNMS-----EDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLmgvavnnpPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQT
| | ..      ..  | |   .||.|.|  ||... .||..|...||.              | ||||||||||.|... ..| | .|..  . .  .|
ldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln........rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifet

LVELREQRAKVVQTEEQYEFCLRTLLEVARKRQTAE
  .||.||  .||  |||.|. | ||.   . .| |
vkdLrsqRnllvqsleqYvflyralldyssygdtde
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 4077-4299 5e-52 172.0 In-house 80-289 (298) alignment 
Range on Protein: 4077-4299
Range on HMM: 80-289/298.0
QDEQNSYINANHVTfAEEGRTlWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydalVFGDLKISLVKSVSSGNYTIRG
.||.  |||| ..  | .||.  .||.|.||. || ||||||.|. .. .||.|  .| .|.|...|||.|  |     .|....|| .. . .....| 
adeesdYiNAsflh.aykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke....tygeitvsllskeefadlivrk

LRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREiRVRLMGvavNNppwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELR
| | . .|.  |.| .|..| |||..||.. .|.||.....|    .  |   |.   | .|.|||||||.|  . ..| | |...      .|..  ||
lkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqag...nk...pvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlR

EQRAKVVQTEEQYEFCLRTLLEV
..|...||||||| |.    ||.
kkrpgavqteeqYvfiyeavlea
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 4077-4303 4.5e-51 168.8 In-house 71-286 (319) alignment 
Range on Protein: 4077-4303
Range on HMM: 71-286/319.0
QD-EQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETgeydALVFGDLKISLVKSVSSGNYTIR
.. |.  ||||...   .| .   .||.|.||  |. ||||||||..| ||||.|. || .|||...|||.|.      ..| | . | .     .| ||
dgvegsdyinasfidgyqerek..fiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeen....feeyGrlivtleeeeeledyiir

GLRVRNMSEDL-MRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVE
 | ... |...  |.| | |||.|||| ||..  ||||.. .||. | .       .   | ||||||||||||  . ..  | |...    .  .|  .
klklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrek.......tqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsr

LREQRAKVVQTEEQYEFCLRTLLEVARKR
|| ||  .||..|||.|.  .|||..   
lRtqRnimvqrpeqYkfiyealleaveag
subfamily_PTPRG_pd Subfamily PTPRG 4077-4306 1.9e-48 160.1 In-house 72-293 (563) alignment 
Range on Protein: 4077-4306
Range on HMM: 72-293/563.0
QDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydalVFGDLKISLVKSVSSGNYTIRG
....  |||||..   . ..   .||.||||. |. |||||.||| ..|.||.|  || |. ||..|||... |     .| |.. |...     ||.| 
kkkklDYinAnyidGyqkska..fiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdese....tygalqvtlieeevlalytvrt

LRVRN-----MSE-DLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIreirvrlmGVAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQ
| ..|      .. |  ..| . .|| ||||.||. .   | |.             | ..   |.||||||||||||... ... | ...|    |  .
lviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks........saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfg

TLVELREQRAKVVQTEEQYEFCLRTLLEVARKRQTA
.|  .| ||  .||||||| |   .|||. . ..| 
flkhiraqRnflvqteEqYiflhdalleaiaskete
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 4077-4299 2.7e-48 159.3 In-house 33-241 (250) alignment 
Range on Protein: 4077-4299
Range on HMM: 33-241/250.0
QDEQNSYINANHVTFAEEGrtLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVkCERYWPTETGEydalVFGDLKISLVKSVSSGNYTIRG
 |..  |||| ..   .|     .||.||||. |. ||||||.|. |. .||.|  .| .|. ...|||.|. |     .||...|| ..   ..||.| 
gdkesdyinasflhgyder..kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae....kyGdvtvsllskeefadytkrk

LRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvaVNNPpwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELR
| . . ..   |.| .|....||| .||..  . |.......  . .     ..|   | .|.|||||||.|  . ... | ||..    . .. .  ||
lklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq.....agna..PvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlr

EQRAKVVQTEEQYEFCLRTLLEV
..| ..|...||| |. . .|. 
kdrphavesleqyvfvyeiilka
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 4077-4305 1.4e-46 153.8 In-house 68-282 (315) alignment 
Range on Protein: 4077-4305
Range on HMM: 68-282/315.0
QDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGeyDALVFGDLKISLVKSVSSGNYTIRG
.. .. |||| ..   .. ..  |||.||||. .| ||||||...    .||||   || |.|| .||| . .  |.  || .|..|..  . .. ..| 
dsPdsdyinasyiksvdddka..yiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrka..dsvefGsikvellsleadtdgvark

LRVRNMSEdlMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIReirvrlmgVAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELR
| .|.  |   |||   |.| |||. |.|  |||| .| |..           ..  .. .||||||||||||.. ... . .....   .  ... .||
lvtrksee..srtvtqfqftewPdkGvdkqtssllklikevk........adngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlr

EQRAKVVQTEEQYEFCLRTLLEVARKRQT
..| ..|||||.| |   ..||    |.|
akrpylvqteeeyafiydavledllwrnt
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 4077-4299 8e-46 151.4 In-house 73-278 (315) alignment 
Range on Protein: 4077-4299
Range on HMM: 73-278/315.0
QDEQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgeydALVFGDLKISLVKSVSSGNYTIRG
.|..  |.||| .   .  |   |||||||.. .|.||||.|.|.    .||.|. ||| | |.|.||| .      ...| . .....     .||.| 
ndphsdyvnanfidGynkkrr..yiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.....kviyGkitvtrkseevnteytvrt

LrvRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMgvavnnppWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELR
|    ...| .|.|  |.||.|||  |||   .|...|  ..  .   .         . |||||||||||| .. ... | ..|     .  . .  .|
l..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv........gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvr

EQRAKVVQTEEQYEFCLRTLLEV
..| |.||. |||.|   .||| 
qnrikmvqvaeqyqfiydallet
0046846 (Phosphotyrosine protein) phosphatases II 4077-4298 2.9e-37 123.5 In-house 8-171 (176) alignment 
Range on Protein: 4077-4298
Range on HMM: 8-171/176.0
QDEQNSYINANHVTFAeegrtlWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDalvfgdlkislvksvssgnytirg
 |.  .||||| .  .      ..|| |||||.|. ||..|..|.| ..||..| ||| |..|| .||| ....                          
ldldldyinanlilgs......rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

lrvrnmsedlmrtvwHLQYTAWPDHSVPKTpSSLLDFIDEIREIRvrlmgvavN-NppWPTVVHCSAGVGRTGVLMLVEseLIRLeqGMRPNPRQTLVEL
               . ... ||||.||   . ||.....||| .        . .   |..||||||.||||.| .    |..|  ..  .. ..| ..
...............qylhlpwpDhgvpdl.elllellefireal........keg..gpvlVHCsaGigRtgtlvaay..llel..ekglsveealalv

REQRA-KVVQTEEQYEFCLRTLLE
||||  ..|||.|||.|. . .|.
reqRplgavqtpeQyrflyefell
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 4078-4298 4e-42 139.6 In-house 86-289 (319) alignment 
Range on Protein: 4078-4298
Range on HMM: 86-289/319.0
DEQNSYINANHVTFAEegRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTgeveggKVKCERYWPTETGEYDAlvFGDLKISLVKSvsSGNYTIRGL
 |   |||| .||     |   ||||||||. |. |||||.||. .  .|..|      | || .||| .. . .    ...|...|.   . .|..| .
eefsdyinasfvtGyq..rkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikee..rfkvkvdsvee..taeyvvrdi

RVRN-MSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELR
.. .   |  .| .    .  |||. ||. || |. ... .| .. .      .| . . ||||||||||||| . ..  | |...  . .  ... .||
elsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsk......enhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlr

EQRAKVVQTEEQYEFCLRTLLE
.|| ..||   || |.  .|||
qqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 4078-4298 8.3e-42 138.6 In-house 50-253 (284) alignment 
Range on Protein: 4078-4298
Range on HMM: 50-253/284.0
DEQNSYINANHVTFAEegRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTgeveggKVKCERYWPTETGEYDAlvFGDLKISLVKSvsSGNYTIRGL
 |   |||| ..|     |   |||.||||. |. |||||.||. .  .|..|      | || .||| .. . .    ...|...|.   | .|..| .
eefsdyinasfitGyq..rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikee..rfkvkvdsvee..seeyvvrdi

RVRN-MSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELR
.. .   |  .|..    .  |||. ||. || |. ... .| .. .      .| . . ||||||||||||| . ..  | |...  . .  ... .||
elsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltsk......enhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlr

EQRAKVVQTEEQYEFCLRTLLE
.|| ..||   || |.  .|||
qqrntlvqdlvqykfiysalle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 4078-4298 9.2e-41 134.6 In-house 26-237 (237) alignment 
Range on Protein: 4078-4298
Range on HMM: 26-237/237.0
DEQNSYINANHVTfAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTeTGeyDALVFGDLKISLVKSVSSGNYTIRGL
  .  ||||...    .|    ||||||||  .  |||.|||..   ..||.|| .|| ..|| .|||  |   .   .| | .|| |     .||.| |
gsgsdyinatylk.gfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywps.td..qpaaygvltvslkkkeefsdytvrsl

RVR-NMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREirvRLMGVaVNNPPWptVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELR
 .  ...   .| ..  |.|.|||. ||.  ..|| |  .| .   |   |  .  ||  ..||||||||||....... | . ..    .  . .  . 
llskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniin...rsphv.sesgpw..iihcsagvgrtgiflvidamlrqakekkvvdiynyvysie

EQRAKVVQTEEQYEFCLRTLLE
|.|  ..||..|| |  .|.||
edrpyiiqtkdqyvfihqtile
0043147 (Phosphotyrosine protein) phosphatases II 4078-4293 7.6e-37 122.0 In-house 2-154 (172) alignment 
Range on Protein: 4078-4293
Range on HMM: 2-154/172.0
DEQNSYINANHVTFAEegRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEveggkvkcerywptetgeydalvfgdlkislvksvssgnytirgl
|| . ||||... .     .  .|| ||||. |. |||||..|.| ...|..|..                                             
degsdyinasyldlyy..ipdrfiatqgplrntladfwrmlkelgithivnltel.............................................

rvRNMSEDLMRTVWHLQYTAWPDHSVPkTPSSLLDFIDEIREIRvrlmgvaVNNPPWPTVVHCSAGVGRTGVLMLVESELirleQGMrpNPRQTLVELRE
   .  |.|.|......|. ||||.|| ... ||.|.. |.|.        ...|  |..|||||||||||.| .    |    .|.  .. ... ..||
..lydpellerlgiqylylpwpDhgvp.llellleflefidell.......alspggpvlVHCsaGvgRtgtlvaaylml....lgl..sleeavalvre

QRAKVVQTEEQYEFCL
.| ..||...|| |..
kRpgavqnpsqyrfly
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 4078-4298 7.4e-35 115.2 In-house 32-238 (239) alignment 
Range on Protein: 4078-4298
Range on HMM: 32-238/239.0
DEQNSYINANHVTfAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYdalvfGDLKISLVKSVSSGNYTIRGL
| .. ||||...    .|    |||.|| .  . ||||||.|..   ..||.|| .|| | || .|||  | .|      .|...| |.    .| || .
dphsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky.....cnlrvtlrktevfadyiirtf

RVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIReiRVRLMGVAvnnpPWptVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELRE
 . .. .   | |.. ..| |||. ||.  ...| .  .|   .  | |      ||  |.|||||||||| ...... | . ..    .  . .  .||
vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit..kdslpgar....pw..vihcsagvgrtgaflvidamlrqakkqktvdifnyvkaire

QRAKVVQTEEQYEFCLRTLLE
.| ..||| ||| |   ..||
drphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 4078-4297 1.1e-34 114.7 In-house 33-238 (239) alignment 
Range on Protein: 4078-4297
Range on HMM: 33-238/239.0
DEQNSYINANHVTfAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYdalvfGDLKISLVKSVSSGNYTIRGL
| .. ||||...    .|    |||.|| .  . ||||||.|..   ..||.|| .|| | || .|||  | .|      .|...| |.    .| || .
dphsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky.....cnlrvtlrktevfadyiirtf

RVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIReiRVRLMGVAvnnpPWptVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELRE
 . .. .   | |.. ..| |||. ||.  ...| .  .|   .  | |      ||  |.|||||||||| ...... | . ..    .  . .  .||
vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit..kdslpgar....pw..vihcsagvgrtgaflvidamlrqakkqktvdifnyvkaire

QRAKVVQTEEQYEFCLRTLL
.| ..||| ||| |   ..|
drphmvqtseqyvfihlavl
0044763 (Phosphotyrosine protein) phosphatases II 4078-4297 7.9e-30 99.2 In-house 11-168 (178) alignment 
Range on Protein: 4078-4297
Range on HMM: 11-168/178.0
DE----QNSYINANHVTfaeEGrtlWYIAAQGPlpgtvGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGeydalvfgdlkislvksvssgnyt
         ||||....   .|    |.....|      |......|.| . .|..|.|.|.|..|| .|||.|.|                        
nleglersdyinaseil...pg...lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag........................

irglrvrnmsedlmrtvWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRvrlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRleqGMrpNPRQTLV
                 .. ... .|||.||  .. .|.|.. |.|..        .... |..|||||||||.|.|..    . .   |.  .. . . 
.................iqylhipipDhgvpdllehflefvefieeal........dekggpvlVHCsaGvgRsgtlvaaylmkkl...gl..sleeaie

ELREQRAkVVQTEEQYEFCLRTLL
..||.|  .|....|......  |
lvrerRp.ivpnpgqlrqLyefel
subfamily_PTPRA_pd Subfamily PTPRA 4079-4299 4.8e-49 162.0 In-house 84-294 (330) alignment 
Range on Protein: 4079-4299
Range on HMM: 84-294/330.0
EQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETgeydALVFGDLKISLVKSVSSGNYTIRGLR
|.  |||| ..   .|  .  .||||||.  || |||||.||| |. .||.|   |  . ||..|||.|     .. .|...... ... . .||.| . 
eesdyinasfidGykekdk..fiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeG....lvtyGnirvevedetvlvdytvrkfl

VRNM----SEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvaVNNppwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVE
|...     |.  | |  . .|.|||  || .|  .|... ...... .       .   | |||||||||||| .. ... | |..   . .  ... .
vqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqq.....sag...pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkr

LREQRAKVVQTEEQYEFCLRTLLEV
|| ||...|||.|||||. ..||| 
lrlqrpqmvqtdeqyefiykvlley
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 4079-4305 1.7e-47 156.7 In-house 69-281 (515) alignment 
Range on Protein: 4079-4305
Range on HMM: 69-281/515.0
EQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGeyDALVFGDLKISLVKSVSSGNYTIRGLR
 .. |.|| ..   .  ..  |||.|||.. .| ||||.|...    ..|||   || |.|| .|||   |  |.. || .|..||   . .. ..| |.
Phsdyfnasyipsfdndka..yiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg..dsvkfGsikvelvsleactggikrklt

VRNMSEdlMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLmgvavNnppWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELREQ
|   ..  .|||   ..| |||. |||  |||| .| |..  . ..     .   .| ..|||||||||||.. ..| . . ...   .  ...  .|..
vlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqy.....t...hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqk

RAKVVQTEEQYEFCLRTLLEVARKRQT
| ..|||.||| |   ..||    |.|
rpylvqtqeqyafiygavledllwrnt
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 4079-4304 1.1e-28 94.7 In-house 71-240 (392) alignment 
Range on Protein: 4079-4304
Range on HMM: 71-240/392.0
EQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGkvkcerywptetgeydalvfgdlkislvksvssgnytirglr
 .. |.|| ..   .  ..  |||.||| . .. ||||||...    ..|||   ||                                           
pdsdylnasyipsfdneka..yiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........................................

vrnmSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIReirVRLmGvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELREQ
      | .|||   ..| |||. |||  |||| || |..   .   |    .   | ..|||||||||||.. ..| . . ..    .  . ....|..
....kgddartvaqfhftewPdkdvpkhtssllkfikevk...adf.G....qythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrk

RAKVVQTEEQYEFCLRTLLEVARKRQ
|  .|||.||| |   ..||    |.
rpymvqtkeqyafiygavledllwrn
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 4079-4305 3e-19 63.7 In-house 77-295 (310) alignment 
Range on Protein: 4079-4305
Range on HMM: 77-295/310.0
EQNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtGEYDalVFGDLKISLVkSVSSGNYTIRGLR
  . || ||.|       |  .| .||||  |. |||||.... .. ....   .| |. ||  |||.  |  .   .| .... . | || .. |  | 
ryedyihanyvktnylrst..ficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl.gvte..tygcirvtnl.sesseefeicnla

VRNMSED---------LM-RTVWHLQYTAWPDHSVPKtpsslldfiDEIREIRVRLMGVaVNNPpwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNP
|  . ..         |    |  ...  |||  ||          .    .  ||.   |     | |||||||..|..|.. .. .. .|..| . . 
vtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpd.........ekchtvpqrllaq.vrhg..pcvvhcsagkdrlyvvvalklkidkldrglkvda

RQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKRQT
 .   ||. .||...||| || .  |  .  ||  . 
eevktellksraiciqtelqyliidrvriifargete
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 4079-4147 4.5e-16 53.5 In-house 81-153 (350) alignment 
Range on Protein: 4079-4147
Range on HMM: 81-153/350.0
EQNSYINANHVTFA---EEGRTLW-YIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTE
. | |||||..  .    |  . . |||.|.||| || ||.... . . ......| .|| .  ||.|||.  
stnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqeg
0041856 (Phosphotyrosine protein) phosphatases II 4080-4301 2.9e-40 133.2 In-house 18-172 (182) alignment 
Range on Protein: 4080-4301
Range on HMM: 18-172/182.0
QNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTgeveggkvkCERYWPtetgeydalvfgdlkislvksvssgnytirglrv
 ..||||| . ..  ...  .||.||||..|| ||.||..|.| ...|..|         .|.|||                                  
dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywp..................................

rnmsEDLMRTVWHLQYTAWPDHSVPKtPSSLLDFIDEIREirvrlmgvavnnPPWPTVVHCSAGVGRTGVLMLVEseLIRLEqgmRPNPRQTLVELREQR
    |.|.|......|. ||||.||  ...|||||.|..|            .. |..|||||||||||.| .    |..     . ...... ..|..|
....ellerlgiqylylpwpDhgvpd.ldelldfieevle............eggpvlVHCsaGvgRtgtlvaay..lmkkl...gvsleeavklvrsrR

AKVVQTEEQYEFCLRTLLEVAR
 ..|.|..|| |. . |||. .
pgmvitpnqyfflqlallelll
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 4080-4307 1.4e-25 84.5 In-house 65-278 (281) alignment 
Range on Protein: 4080-4307
Range on HMM: 65-278/281.0
QNSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETgeYDALVFGDLKISLVKsvSSGNYTIRGLRV
   || ||..      |   || .|||   |  |||||.|.. .  .||.   .|  . ||  |.| ..  . .| |  | .|     |. | ..   |.
stdyihanyirspflkrg..yiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna..hcclqfdklsvsyed..stvnkslvttrl

RNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFideIREIRVRlmgvavNNppwPTVVHCSAGVGRTGVLMLVESELIRLEQGM-RPNPRQTLVELRE-
    |   | . |  .  |||  ||..   .|     .|.|| |           | |.||||||||.| || ||  |  .   .  |. .| .  ||  
nlsyegetrlithwlwkewpdwqvpessevmlki...lrkirar......st...ppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvt

QRAKVVQTEEQYEFCLRTLLE--VARKRQTAE
 ||  ||| .|| .  . ||.  || |. | |
graasvqtlqqymliwkvlldfgvaykqitee
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 4080-4146 3.6e-11 37.0 In-house 89-155 (349) alignment 
Range on Protein: 4080-4146
Range on HMM: 89-155/349.0
QNSYINANHVTFAEEGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPT
 . |||||.. ...      ||| | ||| || ||....  .| ..|. .. . | .  ||..||  
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 4080-4146 1e-07 25.8 In-house 121-180 (244) alignment 
Range on Protein: 4080-4146
Range on HMM: 121-180/244.0
QNSYINANHVTFAeeGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVmVTGEVEggkvKCERYWPT
 |.||||  |     |||  || .| ||  |  |||.|. |.  ...| | | ||    . . ||| 
gntyinasfvgcl..grtaeyiltqhpladtsmdfwkmmlerhvnvlv.vlgsve....eedeywpd
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 4080-4147 9e-06 20.0 In-house 12-72 (130) alignment 
Range on Protein: 4080-4147
Range on HMM: 12-72/130.0
QNSYINANHVTFAeeGRTLWYIAAQGPLPGTVGDFWRMVWEQGSQIVVmVTGEVEggkvKCERYWPTE
.| ||||. |     |||  |. .| ||  |  |||.|. |.   ..| | | ||    . . |||  
gntyinasfvGll..grtaeylltqhpladtsmdfwkmmleryvnvlv.vlgsve....eedeywpds
0051429 (Phosphotyrosine protein) phosphatases II 4081-4306 9.9e-45 148.6 In-house 4-231 (272) alignment 
Range on Protein: 4081-4306
Range on HMM: 4-231/272.0
NSYINANHVTFAeeGR---TLWYIAAQGPLPGTVGDFWRMvWEQGSQIVVMVTGEVEGGKVKCERYWP--------TETGEYDALVFGDLKISLVKSVSS
..||||..|     ||      .....|||| |. ||||. .|.|   .|....|.| |..||.||||        ..  ..    .|.| . |.. .  
sgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

GNYTIRGLRVRNM-SEDLMRTVWHLQYTAWPDHSVPKTPssLLDFIDEIREirvrlmgvavnnpPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPN-
 .|..| |..... | . .|.|.||.||.||||.||. .  ||........             . | .||||||..|||.. ..   | ...     . 
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.............ggpvlvHCsaGkdRTGtvvallllllgvsletivdd

-------PRQTLVELREQRAKVVQTEEQYEFCLRTLLEVARKRQTA
       ..... |||.||...|||||||.|... |||..|. ...
Ylltnlyleeaveelraqrpgavqteeqylflyeallellrsllsv
0036282 (Phosphotyrosine protein) phosphatases II 4081-4293 4.4e-39 129.3 In-house 2-163 (174) alignment 
Range on Protein: 4081-4293
Range on HMM: 2-163/174.0
NSYINANHVTFAEEGRtlWYIAAQGPLPgtvgdFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTetgeydalvfgdlkislvksvssgnytirglrvr
..||||... . .  .   .|| ||||.     ||.|..|.|...|||.. |.| |..|| .|||.                                  
sdyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................

nMSEDLMRTVWHLQYTAWPDHSVPKTPSsLLDFIDEIREIRVRlmgvavnNPPWPTVVHCSAGVGRTGVLMLVESELIRLEqgmrPNPRQTLVELR---E
 ..||| |......|. ||||.|| ..  ||.|.....|.. .       .|  |..|||||||||||.|..    | .|.    ..... |  .|    
.lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.......dpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRl

QRAKVVQTEEQYEFCL
|| ..|||..||.|. 
qrpgmvqtpsQyrfly
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 4081-4298 6.1e-33 108.9 In-house 76-277 (439) alignment 
Range on Protein: 4081-4298
Range on HMM: 76-277/439.0
NSYINANHVTFAEEGRtlWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKvkcerYWPTEtgeyDALVFGDLKISLVKSVSSGNYTIRGLRVR
  |||||..    . .   |||.|||   |. ||||.|.|. .  .||.|  ||  |     |||..    .  ..||. .   . .   ||.|||..| 
shyinanyikGyyddk..lyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsd....aevcygdiavrvdrnielpnyvirgfkvf

NMSE--DLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREirvrlmgVAVNNPPWPTVVHCSAGVGRTGVLMLVESELIRLEQGMRPNPRQTLVELREQ
|  .  .  ||| ...|.||||. ||   | .|||.  |            ..   | |||||||||||| .. ..  | .|    . . .  .  ||.|
nerdttekertvlqfhyiawpdknvpaqashvldflrains.......andkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkq

RAKVVQTEEQYEFCLRTLLE
| ..||.  || |   ..||
rkqmvqalcqyvfiynavle
0049772 (Phosphotyrosine protein) phosphatases II 4081-4300 9.3e-31 103.1 In-house 72-280 (314) alignment 
Range on Protein: 4081-4300
Range on HMM: 72-280/314.0
NSYINANHVTFAeegrtLWYIAAQGPLPGTVGDF----------WRMV--WEQGSQIVVM---------------------VTGEVEGGkvkcerywpte
 .||||..|        | .||.||||. || ||          ||||  ... . ..||                      ..  ..|           
sdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...........

tGEYDALVFGDLKislvksvssgnytirglRVRNMSEDLMRTVWHLQYTAWPDHSVPkTPSSLLDFIDEIREIrvrlmgvavnNPPWPTVVHCSAGVGRT
 .|..|  . .||                 .. .  |.. |.. .. .. .||.|.| ... ...|.. |.|           ... |..|||.||.|||
.neptaadlellk.................eelydpelferlgikylripvpDgsap.lledfdeflefieea..........dkggpvlvHCkaGkgRt

GVLMLVESelIRLEQGMrpNPRQTLVELREQRA-----KVVQTEEQYEFCLRTLLEVA
|.....    . . .|.  .....| ..|..|        ... |||||.|. |||  
gtfvvaay..lmkllgv..sleealedvrlkRpinpnpgfieqleqyefilealleyl
0051082 (Phosphotyrosine protein) phosphatases II 4081-4297 1.7e-30 101.0 In-house 3-150 (151) alignment 
Range on Protein: 4081-4297
Range on HMM: 3-150/151.0
NSYINANHVTfaeEGrtlwYIAAQGPLPgtvgDFWRMVWEQGSQIVVMVTGEVEGGkvKCERYWPTETgeydalvfgdlkislvksvssgnytirglrvr
..|||.. ||   .|    ... .|||.    ||.....|.| . .|....|.| |  .| .|.| .                                 
sdyinfsyvt...gg....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

nmsedlmRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREirvrlmgvavnNPPWPTVVHCSAGVGRTGVLMLVEseliRLEQGmrPNPRQTLVELREQRA
       ..|.|.... |||...| .. ..|.|......           ... |..||||||.||||.|...     .. .|   .. ..| |.|..| 
.......ievlhipildwpdpglplsfdavleflellld...........kkngpvlvHCsaGkgRTGtlvaly....lmllg..vsleealeeyrlkrp

KVVQTEEQYEFCLRTLL
 |||...|. |.|. ||
gvvqpnqqflfqlfall
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 4081-4306 2.4e-25 83.9 In-house 73-293 (305) alignment 
Range on Protein: 4081-4306
Range on HMM: 73-293/305.0
NSYINANHVTFAEEGRTlwYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEYDALVFGDLKISlVKSVSSGNYTIRGLRVR
  || ||.|.   . .   .| .| ||  |  ||| | ...  . . |.   .| |  ||  |.... ..   .  .. ||| ||  ||... .|     
heyihanyvstptnpkr..fictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkis.vkfessvtlkfrkdaka

NMSE---------DLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRvrlmGvavnnppwPTVVHCSAGVGRTGVLMLVESELIRLEQGMRP-NPRQ
...|           .| | |  .  |||  || .  ..|... . |  .    |        |.|||||||.|||| ....|  | .| .|    .  .
kvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk....g........pivvhcsagigrtgsvvmleyildqllagqiiedtdk

TLVELREQRAKVVQTEEQYEFCLRTLLEVARKRQTA
 |. .|||| . .||..|| |  . .|.  ||..  
ilqkireqrnnsiqtdaqylfvhqvilnyfrkkkll
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 4081-4295 1.1e-15 52.5 In-house 46-254 (290) alignment 
Range on Protein: 4081-4295
Range on HMM: 46-254/290.0
NSYINANHVTFAEEgrtLWYIAAQGPLP-------GTVGDFWRMVWEQGSQIVVMVTgEVEGGKV-----KCERYWPTETGEydALVFGDLKISLVKSVS
. || ||.||...    |  |. | |.         |. .|| |. .  .. |||.  |.|  .       |..| |.. ||   | |..|...  . . 
ddyiHAnrvtcpng...lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlc.efeeksantslfaCakYvpesvge..elkfkgltvkCkskek

SGNYTIRGLRVRnMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIreirvrlmgvavNNPPWPTVVHCSAGVGRTGVLMLVESELIRLE-QGMRPN
  .  .| | |.   ..   || | ..  | . .|.... .||. |. .            ..   | .|||  |. |  .|  ..     .  .    .
eddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkv............kasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvk

PRQTLVELREQRAKVVQTEEQYEFCLRT
 .. | .||.|||......... | .  
ledvlkalrkqralaitsalelafvdag
0049260 (Phosphotyrosine protein) phosphatases II 4098-4293 2e-33 110.6 In-house 9-143 (152) alignment 
Range on Protein: 4098-4293
Range on HMM: 9-143/152.0
LWYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWptetgeydalvfgdlkislvksvssgnytirglrvrnmsedlmrtvwHLQYTA
  .||.|||.| |. |||||..|.| ...||.| ..| ||.|||.|.                                               . ... 
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...............................................qylhlp

WPDHSVPKTPSSLLDFIDEIREIrvrlmgvaVNNPPWPTVVHCSAGVGRTGVLMLVESELirleqgMRPNPRQTLVELREQRAKVVQTEEQYEFCL
||||.||. .  ||.... |...          ..  |..|||||||||||.|..    |      .. .. ...  .||.| ..|....|..|..
wpDhgvpdlsqlllflllfiekl........aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 4099-4253 6.2e-18 59.7 In-house 5-154 (198) alignment 
Range on Protein: 4099-4253
Range on HMM: 5-154/198.0
WYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgEYDALVFGDLKISLVKSVSSGNYTIRGLRVRNMS--EDLMRTVWHLQYT
 |||.| ||  |. |||.|||| ||  .|||  .    ..    ||||   |  .  .| | ..    ..  .|||  | . | .      | . | |.|
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywptt..esgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

AWPDHSVPKTpSSLLDFIDEIREIRVRLMgvavNNPPWPTVVHCSAGVGRTGVLMLV
.| ... |.  . .. |.   ||.  .      ..   | .|||| | | |||.. .
swkekttpnv.alfvgfvvasrevskkye....qekdapvivhcsdgqgftgvfval
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 4099-4253 6.3e-18 59.7 In-house 6-155 (199) alignment 
Range on Protein: 4099-4253
Range on HMM: 6-155/199.0
WYIAAQGPLPGTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTEtgEYDALVFGDLKISLVKSVSSGNYTIRGLRVRNMS--EDLMRTVWHLQYT
 |||.| ||  |. |||.|||| ||  .|||  .    ..    ||||   |  .  .| | ..    ..  .|||  | . | .      | . | |.|
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywptt..esgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

AWPDHSVPKTpSSLLDFIDEIREIRVRLMgvavNNPPWPTVVHCSAGVGRTGVLMLV
.| ... |.  . .. |.   ||.  .      ..   | .|||| | | |||.. .
swkekttpnv.alfvgfvvasrevskkye....qekdapvivhcsdgqgftgvfval
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 4102-4300 2.1e-18 61.3 In-house 39-221 (255) alignment 
Range on Protein: 4102-4300
Range on HMM: 39-221/255.0
AaqgplpgTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLVKsvSSGNYTIRGLRVR-NMS-EDLMRTVWHLQYTAWP
        ||  |....  .... |||..   | |..||..|.|.|  |   |.. |....  |  || .  .| |..  ...     .|| | .|. |.
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekde..klkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWi

DHSVPKTPsslldfideiREIRvRLMGVAVNNppWPTVVHCSAGVGRTGVLMLVESELIRLEQGMR------PNPRQTLVELREQRAKVVQTEEQYEFCL
..  |. .          |||.  .. |. .    . |||||.|.||.  ..|.|.   .. . ..       . .. | |||..|.. ..|  |  |..
eknaPela..........reil.nilkvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsi

RTLLEVA
 ..|.. 
lmvldlv
subfamily_hpo-7_pd Subfamily hpo-7 4109-4299 9.6e-15 49.2 In-house 45-226 (263) alignment 
Range on Protein: 4109-4299
Range on HMM: 45-226/263.0
GTVGDFWRMVWEQGSQIVVMVTGEVEGGKVKCERYWPTETGEydALVFGDLKISLVKSVSsgNYTIRGLRVRNMSE--DLMRTVWHLQYTAWPDHSVPKT
 |.  |....  .... |||..   | |..||..|.|.|  |   ... .....  |..|  .  .. | . .. .    ..|| | .|. |...  |. 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekde..kqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

PSSLLDFIDEIREIRvrlmgvavnnppwPTVVHCSAGVGRTGVLMLVESELIRLEQGMR------PNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEV
. . |  ..  |. .             . |||||.|.||.    ..|.   .. . ..       . .. | |||..|.. ..|  |  | . ..|..
areilnilkvarnsk.............slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdf
0048076 (Phosphotyrosine protein) phosphatases II 4154-4296 4.5e-22 73.7 In-house 11-139 (145) alignment 
Range on Protein: 4154-4296
Range on HMM: 11-139/145.0
LVFGDLK------------ISLVKSVssgnytirglrvRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvavnnpPWPTVVHCS
| .|.|             | .| ..             .. |.| |......|. ||||.||  .. ||.|.. |.|.. .         . |..||||
lylgslptaldlellkdlgittvlnl............tselellerlgiqylylpwpDhgvpdllellleflefieealke.........ggpvlVHCs

AGVGRTGVLMLVEseLIRLeqgMRPNPRQTLVELREQRAKVVQTEEQYEFCLRTL
|||||||.|..    |..|   .. .. ..| ..|.|| ..|....|..|... .
aGvgRtgtlvaay..lmll...lgvsleealelvrsqrpgavpnpgqlrflyefe
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 4164-4298 5.9e-13 42.9 In-house 69-192 (440) alignment 
Range on Protein: 4164-4298
Range on HMM: 69-192/440.0
VKSVSSGNYtirgLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvAVNNppwPTVVHCSAGVGRTGVLMLVESELIRLEQG
||.| . .|    .    ..    ||. . .| .|||..|||  . .| .|... | . .    | |    | .||||||.|||||.. |.| |   .. 
vkgvpdsdy....inasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqek....agng...pllvhcsagagrtgviiavdsilreakrs

MRPNPRQTLVELREQRAKVVQTEEQYEFCLRTLLE
 . .    .  .|..| ..||| ||| |   ..||
dqidifsfinsmrnnrpqmvqtpeqyafvheavle
0048179 (Phosphotyrosine protein) phosphatases II 4166-4294 9e-21 69.5 In-house 25-139 (144) alignment 
Range on Protein: 4166-4294
Range on HMM: 25-139/144.0
SVSSGNYTIRGLRVRNMSEDLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIrvrlmgvavNNPPWPTVVHCSAGVGRTGVLMLVEselIRLEQGmr
  . | .|.  |.     |.| |........ ||||.||  .. ||.|.. |.|.          ... |..|||||||||||.|..     . ...|  
lkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieea.........leeggpvlVHCsaGvgRtgtlvaay...lmkklg..

PNPRQTLVELREQRAKVVQTEEQYEFCLR
 .. ..| ..|..|  .|....|..|.|.
lsleealalvrsrrpgavpnpgqlrfLle
subfamily_PTPDC1_pd Subfamily PTPDC1 4184-4294 3.7e-08 28.0 In-house 76-170 (182) alignment 
Range on Protein: 4184-4294
Range on HMM: 76-170/182.0
EDLMRTVWHLQYTAWPDHSVPkTPSSLLDFideireirVRLMGVAVNNPpwPTVVHCSAGVGRTGVLMlvESELIrLEQGMrpNPRQTLVELREQRAKVV
|.||..       .|.|..|. .  ..||         |...  |...    . ||| || ||||||.   . |.   . .  .. ...  .|..|.| .
ealmeqgiyvynfgwkDygva.sleriLdi........vkvvafalqeg..kvavhChaGlGrtGvli..acylv.yakrl..taekaiklvrskrpksi

QTEEQYEFCLR
|| || |..  
qtreqvelvke
0038934 (Phosphotyrosine protein) phosphatases II 4185-4292 5.8e-07 24.9 In-house 74-169 (194) alignment 
Range on Protein: 4185-4292
Range on HMM: 74-169/194.0
DLMRTVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRlmgvavnNPPWPTVVHCSAGVGRTGVLMLveSELIRLeQGMrpNPRQTLVELREQRAKVVQ
....   .     .||. .. . . ||.|.| . |.  .       .|.   .||| ||.||||.|    . ||   .||  .... .  .|| | ....
efekagieylklpfpddgtvPsleillrfldlvdeflne.......dpggvvaVHCkaGlgRtGtlva..aYLiyr.lgm..saeeAialfrekRpgaip

TEEQYEFC
. ...|  
nqdyleal
PTPc_DSPc_SM00012 4189-4298 1.4e-27 91.3 In-house 1-105 (105) alignment 
Range on Protein: 4189-4298
Range on HMM: 1-105/105.0
TVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMGvavnnpPWPTVVHCSAGVGRTGVLMLVESELIRLEQG-MRPNPRQTLVELREQRAKVVQTEE
|| |..||.||||.||....|.|........ .             |.||||||||||||......  | .||..  ...  |.. |||.||...|||||
tvkhyhytgwpdhgvPeesdsilellravkknknkses......skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqtee

QYEFCLRTLLE
|| |..| |||
qylflyralle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 4189-4300 4e-12 40.5 In-house 216-344 (350) alignment 
Range on Protein: 4189-4300
Range on HMM: 216-344/350.0
TVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMG--VAVNNPPWPTVVHCSAGVGRTGVLMLVESELI---RL-------EQGMRPN-----PRQT
 |..||.  |.| |.   | |.|  ..   ..   |.      |.   | .|||||||||||.|. ..| |     |       ..  ...       ..
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

LVELREQRAKVVQTEEQYEFCLRTLLEVA
. |||.|| ..||. .|. |.  .||   
vnelrkqrismvqnldqfifiYeallfyf
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 4189-4299 6.3e-08 26.3 In-house 219-343 (349) alignment 
Range on Protein: 4189-4299
Range on HMM: 219-343/349.0
TVWHLQYTAWPDHSVPKTPSSLLDFIDEIREIRVRLMG-VAVNNPPW-PTVVHCSAGVGRTGVLMLVESELIRLEQ-----------GMRPNP-RQTLVE
 .. ||.  |.| |.   | |.|  ..   ..   |.    ...    . .|||||| ||||||. ... |  ||             .. ..   .. |
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

LREQRAKVVQTEEQYEFCLRTLLEV
|| ||  .||   |. ... .||. 
lrkqrismvqnlaqfiaiyealLky
subfamily_CG42327_pd Subfamily CG42327 4235-4301 8.9e-12 39.3 In-house 249-316 (319) alignment 
Range on Protein: 4235-4301
Range on HMM: 249-316/319.0
PTVVHCSAGVGRTGVLMLVESELIRLEQGMR-PNPRQTLVELREQRAKVVQTEEQYEFCLRTLLEVAR
| ||||| ||||||...  . .. .||.  |  .  |..  .|..||. |.| |||||  ..| | |.
PlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak