Gene MbrePTP-Un-10 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP054_AA protein Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 29-306 8.5e-73 239.8 In-house 29-270 (274) alignment 
Range on Protein: 29-306
Range on HMM: 29-270/274.0
EDLNRYFNILPNNHTRFVPASPTKIadmginlsmttppqtqlvptrspspclscrvllprigdDERTEYINANFISGYGpRAMDRYIATQGPLPHTILAF
.  ||| .||||...| .  | .                                        || ..|||||.| ||. .    |.|||||||.|.  |
qtknryktilPnensrvllesesse......................................dedssyinanyikGyd.eeskayvatqGPlpntvadf

WRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGT--SVVYGDYVIRLQtETNTCPQFVTSKLLISCGDDdIREITHLWWRAWPDQGVPETADGIFPFI
|||... ...|||| |.| |.|  ||..|.|.. ..  |  |||  |. . ..... ..   ||...   .  |...| |. .|||. .|. |. .. ..
WrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikve.kiverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlv

NTAR---DVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYMRQ
.  .   . .... .|.|||||||.||||||| |.|...| .| .|||.|. ||. | .||  |||  || .|| .| .|...
leveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
0045450 (Phosphotyrosine protein) phosphatases II 29-305 3e-71 236.0 In-house 56-305 (307) alignment 
Range on Protein: 29-305
Range on HMM: 56-305/307.0
EDLNRYFNILPNNHTRFVPASPTkiadmginlsmttppqtqlvptrspspclscrvllpriGDDERTEYINANFI--------SGYGPraMDRYIATQGP
 |.||| .|||..||| .  |..                                      |..| . ||||...        .||     ...||||||
kdknrykdilpydhtRVklssld......................................gsledsdYiNAsyvrvpllllldgydl..krkfIatqgP

LPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDvGTSVVYGDYVIRLQTETNtCPQFVTSKLLISC--GDDDIREITHLWWRAWPDQGVPET
||.|.  ||||.|| ...|||| |.|||.. .|| .|||.. |....||.....|  |.  .. ..  .| ...  |..  |..||... .|||.|||..
lpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpps

ADGIFPFINTARDVADE--EGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGV---VDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYMR
 . .. ||. .|.. .|  .|||..|||||||||||.|| ... ..| .. |.   ||.|. |.. |.||. .||.| ||.... .|||. .
feelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
0050432 (Phosphotyrosine protein) phosphatases II 30-305 4.2e-79 261.4 In-house 70-300 (308) alignment 
Range on Protein: 30-305
Range on HMM: 70-300/308.0
DLNRYFNILPNNHTRFVPaSPTkiadmginlsmttppqtqlvptrspspclscrvllprigdderTEYINANFISGYGPRAMDRYIATQGPLPHTILAFW
|.||| .|||. |.| .  ...                                           . ||||....||  .   ..||||||||.|.  ||
dkNrykdilpydhsRVkl.deg...........................................sdYInAsyvdgyssklprkfIatqgPlpntvedFw

RMVWESKTHVIVMSTDLVENNAVKCERYWPQDVG-TSVVYGDYVIRLQTETNtCPQFVTSKLLISC-GDDDIREITHLWWRAWPDQGVPETADGIFPFIN
||||| ...|||| |.||||. .||..||| ..| .|..||.....|  |.. .. ... .| ... ||.. |..||... .|||.|||. .. .. |..
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldfle

TARDVAdeEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYMR
 .|..   .||||||||||||||||.|| .|. ..|... | ||... |.| |.||  .|||| ||.... .||||..
lvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
0036941 (Phosphotyrosine protein) phosphatases II 30-305 3.6e-74 245.0 In-house 41-278 (297) alignment 
Range on Protein: 30-305
Range on HMM: 41-278/297.0
DLNRYFNILPNnhtrfvpasptkiadmginlsmttppqtqlvptrspspcLSCRVLLprigDDERTEYINANFISGYgpRAMDRYIATQGPLPHTILAFW
..||| .|||.                                        ..|| |    ||| . ||||....||  .   ..||||||||.|.  ||
eknRykdilpy.......................................dhtRVkl....ddegsdYinAsyvdgy..dlkrkfIatqgPlpntvedFW

RMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRLQTETNT-CPQFVTSKLLISC-GDDDIREITHLWWRAWPDQGVPETADGIFPFIN
||||| ...|||| |.|||.. .||..||| ..| |..|||....|.... . .. ... .| ... |... |..||...  ||| ||||... .. ||.
rmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfie

TARDVADE--EGGPIVVHCSAGVGRTGCFINIDIGMQQWD---ELGVVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYMR
 .|.| ..  .|||..|||||||||.|.|| .|. .||..   . | ||||. |.| |.||  .|||. ||.... .|||. .
lvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
0047943 (Phosphotyrosine protein) phosphatases II 30-304 2e-72 239.2 In-house 40-272 (273) alignment 
Range on Protein: 30-304
Range on HMM: 40-272/273.0
DLNRYFNILPNNHTRFVPasptK----IadmginlsmttppqtqlvptrspspclscrvllprigdderteYINANFISGYgpRAMDRYIATQGPLPHTI
|.||| .|||..|.| .     .                                                ||||....||  .   ..||||||||.|.
dknrykdilpydhsrvkl....gdggsd...........................................yinAsyvdgy..nlkrkfiatqgPlpntv

LAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGT-SVVYGDYVIRLQTETNtCPQFVTSKLLISC-GDDDIREITHLWWRAWPDQGVPETADGIF
  ||||||| ...|||| |.|||.. .||..|||...|. |..||.. ..|  |.. .. ... .| ..  |... |..||...  |||.|||.. . ..
edfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesll

PFINTARDVADE--EGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYM
 ||. .|..  .  ..||.||||||||||||.|| .|. ..|. . | ||.|. |.. |.||  .|||| ||.... .||||.
efielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0043336 (Phosphotyrosine protein) phosphatases II 30-304 1.3e-71 236.7 In-house 47-277 (278) alignment 
Range on Protein: 30-304
Range on HMM: 47-277/278.0
DLNRYFNILPNNHTRFVPASptkiadmginlsmttppqtqlvptrspspclscrvllprIGDDERTEYINANFISGygPRAMDRYIATQGPLPHTILAFW
|.||| .|||..|.| .  .                                       .| |. . ||||....|  ..  ...||||||||.|.  ||
dknrykdilpydhsrvklsl.......................................lggdldsdYinAsyvdg..ynvprkfiatqgPlpetvedFw

RMVWESKTHVIVMSTDLVENNAVKCERYWPqdvGTSVVYGDYVIRLQTETNtCPQFVTSKLLISC-GDDDIREITHLWWRAWPDQGVPETADGIFPFINT
||||| ....||| |.|||.. ||| .|||   |.|..|||....|. |.  .. ... .| ..  ||.  |..||... .|||.||||. . .. |...
rmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflka

ARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYM
.|.. . ..||..|||||||||||.|| ... ..| .  | ||... |.. |.||. .|||| ||.... .||||.
vrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
DSPc_SM00195 30-304 5.4e-71 234.4 In-house 28-262 (263) alignment 
Range on Protein: 30-304
Range on HMM: 28-262/263.0
DLNRYFNILPNNHTRFVPASPTKIadmginlsmttppqtqlvptrspspclscrvllprigddERTEYINANFISGYgpRAMDRYIATQGPLPHTILAFW
. ||| ||||..|||    .. |                                        | ..|||||.|.|.  .   .|||||||||.|.  ||
sknRyknilpydhtrVklkkeekk.......................................egsdYINAnyikga..nkkkkyIatQgPlpstvedFW

RMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRLQTETNTCPQFVTSKLLISCGDD-DIREITHLWWRAWPDQGVPETADGIFPFINT
||||| |...||| |. .||.  ||.||||.. |.. ..|.. . |. ....  .... .| ..  .. . |..|......|||.|||.... .. ....
rmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellra

ARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYM
..   ... |||||||||||||||.|. ||| ... .|   ||| . |.. | ||  .|||  || .|. ..|||.
vkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 30-304 5.4e-71 234.4 In-house 28-262 (263) alignment 
Range on Protein: 30-304
Range on HMM: 28-262/263.0
DLNRYFNILPNNHTRFVPASPTKIadmginlsmttppqtqlvptrspspclscrvllprigddERTEYINANFISGYgpRAMDRYIATQGPLPHTILAFW
. ||| ||||..|||    .. |                                        | ..|||||.|.|.  .   .|||||||||.|.  ||
sknRyknilpydhtrVklkkeekk.......................................egsdYINAnyikga..nkkkkyIatQgPlpstvedFW

RMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRLQTETNTCPQFVTSKLLISCGDD-DIREITHLWWRAWPDQGVPETADGIFPFINT
||||| |...||| |. .||.  ||.||||.. |.. ..|.. . |. ....  .... .| ..  .. . |..|......|||.|||.... .. ....
rmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellra

ARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYM
..   ... |||||||||||||||.|. ||| ... .|   ||| . |.. | ||  .|||  || .|. ..|||.
vkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0039614 (Phosphotyrosine protein) phosphatases II 30-306 1.2e-70 233.7 In-house 58-291 (297) alignment 
Range on Protein: 30-306
Range on HMM: 58-291/297.0
DLNRYFNILPNNHTRFVPASPTkiadmginlsmttppqtqlvptrspspclscrvllpriGDDERTEYINANFISGYGPRaMDRYIATQGPLPHTILAFW
|.||| .|||..|.| .  ..                                       | |. . ||||....||  .  ...||||||||.|.  ||
dknrykdilpydhsrvklkped......................................gvdldsdYinAsyvdgydll.trkfIatqgPlpetvedFw

RMVWESKTHVIVMSTDLVENNAvKCERYWPQDVGtsvVYGDYVIRLQTETNtCPQFVTSKLLISCgDDDIREITHLWWRAWPDQGVPETADGIFPFINTA
||||| ...|||| |.|||..  ||..|||...|   .|||....| ...  .. ... .| ..  ..  |..||...  ||| |||.... .. |.. .
rmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh.ldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelv

RDVADE--EGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYMRQ
|..  |  .|||..|||||||||||.|| ... ..| .. | ||.|. |.. |.||. .|||| ||.... .|||. ..
realaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0045098 (Phosphotyrosine protein) phosphatases II 30-307 5.7e-70 231.2 In-house 35-275 (278) alignment 
Range on Protein: 30-307
Range on HMM: 35-275/278.0
DLNRYFNILPNNHTRFVpasptkiadmginlsmttppqtqlvptrspspclscrvllprigddertEYINANFISGYgPramDRYIATQGPLPHTILAFW
|.||| .|||..|.| .                                                 .||||..|.|| |   ...||||||||.|. .||
dknRykdilpydhsrVk.................................................dYINAsyidgy.p...kkfIatqgPlpstvadfw

RMVWESKTHVIVMSTDLVENNAVKCERYWPQdvGTSVVYGDYVIRLQTETNTcPQFVTSKLLISC-----GDDDIREITHLWWRAWPDQGVPETA--DGI
||.|| ...|||| |.|||.. .||..|||   | |..|||....|. |... . ... .||.        |.  |..|||..  ||| |||..   . .
rmlwelgitvivmltelvelgrekcaqywpe..ggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksf

FPFINTARDVADE-------------EGGPIVVHCSAGVGRTGCFINIDIGMQQWdElGVVDILSNVCKTRRQRGL-SVQTPVQYVYIHFVLLEYMRQN
. ...  |.. ..             .|||..|||||||||||... ... ...  | |.||.|. |.. |.||.  .||.. ||.... .|||. ...
lellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell.e.ggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
0040439 (Phosphotyrosine protein) phosphatases II 30-305 1.6e-66 219.7 In-house 13-247 (249) alignment 
Range on Protein: 30-305
Range on HMM: 13-247/249.0
DLNRYFNILPNNHTRFVPASptkiadmginlsmttppqtqlvptrspspclscrvllprIGDDERTEYINANFIsgYGPRAMDRYIATQGPLPHTILAFW
|.||| .|||..|.|..  .                                       ... . . ||||..|   |..  .|.||||||||.|. .||
dknrypdilpydhsrvklsi.......................................lpglflsdyinAsyi..dgyyikrrfiatqgPlpetvedfw

RMVWESKTHVIVMSTDLVENNAVKCERYWPQdvGTSVVYGDYVIRLQTETNtCPQFVTSKLLISC-GDDDIREITHLWWRAWPDQGVPETADGIFPFINT
||.|| . .|||| |.|||.. .||..|||.  |.|..|||....|  ..  .. ... .| ..  .|.. |...|...  |||.|||.. . .. ||. 
rmlwelgitvivmLtslvelgrekcaqywpl..ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfiea

ARDVADE--EGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYMR
.|.. .|  .|||..|||||||||||.|| ... ..| .. . ||... |.. |.||. .||.| ||.... .|||. .
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
0042113 (Phosphotyrosine protein) phosphatases II 30-304 2.8e-64 212.2 In-house 11-243 (245) alignment 
Range on Protein: 30-304
Range on HMM: 11-243/245.0
DLNRYFNILPNNHTRFVPASptkiadmginlsmttppqtqlvptrspspclscrvllprIGDDERTEYINANFIsgYGPRAMDRYIATQGPLPHTILAFW
|.||| .|||..|||..  .                                       .| |. . ||||...   |.|  ...||||||||.|. .||
dknrysdilpydhtrvklsp.......................................dggdldsdyinasyv..dgyritpkfiatqgPlpetvedfw

RMVWESKTHVIVMSTDLVENNAVKCERYWPQdvGTSVVYGDYVIRLQTETNtCPQFVTSKLLISC-GDDDIREITHLWWRAWPDQGVPETADGIFPFINT
||.|| . ..||| |...|.. |||..|||.  |.|..|||....| .|.. .. ... .| ..  |||  ||..|...  |||.|||.. . .. |.. 
rmlwelgittivmLteeeelgrvkcaqywpl..gesltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflef

ARDVAD-EEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYM
.|..    ..||..|||||||||||.|| ... ..| .... |.. . | . |.||. .|||| ||.... .|||..
vrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 30-303 1.5e-60 200.1 In-house 12-241 (243) alignment 
Range on Protein: 30-303
Range on HMM: 12-241/243.0
DLNRYFNILPNNHTRFVPasptkiadmginlsmttppqtqlvptrspspclscrvllprigDDerTEYINANFISGYgPramdRYIATQGPLPHTILA--
. ||| .|||..|.| .                                            ..  . |||||.| .. |    |.||||||||.|.    
sknrysdilpydhsrvkl...........................................eg..sdyinanliyvt.p....rliatqgPlpetveddl

--FWRMVWESKTHVIVMSTDLVENNAVKCERYWPqdvgTSVVYGDYVIRLQTETNTcPQFVTSKLLISC--GDDDIREITHLWWRAWPDQGVPETADGIF
  ||||.|| ...|||| |.|||....||..|||     .|.|||....|  |... ....  .||...   ||  |...|... .|||.|||.. . . 
asfwrmlwelgitvivmltelvElgrekcaqywp....gevtygdftvtllseehl.ddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedll

PFINTARDV--------ADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWdelGvVDILSNVCKTRRQRGL-SVQTPVQYVYIHFVLLEY
 |.. .|..        |. .|||..|||||||||||..| ... ....   | ||... |.. |.||.  .|||| ||.... .|||.
dfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
0041856 (Phosphotyrosine protein) phosphatases II 30-307 5.5e-45 148.5 In-house 3-174 (182) alignment 
Range on Protein: 30-307
Range on HMM: 3-174/182.0
DLNRYFNILPNNHTRfvpasptkiadmginlsmttppqtqlvptrspspclscrvllprigddeRTEYINANFISGYGPRAMdrYIATQGPLPHTILAFW
|.||| .|||..|.|                                                    |||||.. |. |     .|||||||..|. .|.
dknrysdilpydhsr.................................................dldyInanlylgslpatr..fiatqgpllstvadfl

RMVWESKTHVIVMSTdlvennavkCERYWPqdvgtsvvygdyvirlqtetntcpqfvtsklliscgDDDIREITHLWWRAWPDQGVPEtADGIFPFINTA
||..| . ..||. |         .|.|||                                    ..  |.......  ||| |||.  | .. ||...
rmlkelgittivnlt.........eelywp....................................ellerlgiqylylpwpDhgvpd.ldelldfieev

RDvadeEGGPIVVHCSAGVGRTGCFINIDIGMQQwdelGvVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYMRQN
..    ||||..|||||||||||... ... ...    | |.. . |.  |..|  .|.|| ||.... .|||.....
le....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallellllk
Y_phosphatase Protein-tyrosine phosphatase 31-302 1.1e-68 226.6 Pfam-A 4-235 (235) alignment 
Range on Protein: 31-302
Range on HMM: 4-235/235.0
LNRYFNILPNNHTRFVPasptkiadmginlsmttppqtqlvptrspspclscrvllprIGDDERTEYINANFISGYGpRaMDRYIATQGPLPHTILAFWR
 ||| .||| ..||                                             |......|||||...||  .   ..|||||||..||  |||
knRykdilpydktrvkl.........................................kgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWr

MVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRLQ-TETNTCPQFVTSKLLISCGDDD--IREITHLWWRAWPDQGVPETADGIFPFIN
|||. |..|||| |.|.|.. .||..|||.. ..|. |||. ..|.  |.. . .....|| ..  ...   ||...|.. .|||.||||...... .|.
mvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlir

TARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLE
  .   ... ||.||||||||||||.|. .|| ..| .. . ||.|. |.. |.||  .||.  ||.... ..||
kvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 31-302 1.1e-68 226.6 In-house 4-235 (235) alignment 
Range on Protein: 31-302
Range on HMM: 4-235/235.0
LNRYFNILPNNHTRFVPasptkiadmginlsmttppqtqlvptrspspclscrvllprIGDDERTEYINANFISGYGpRaMDRYIATQGPLPHTILAFWR
 ||| .||| ..||                                             |......|||||...||  .   ..|||||||..||  |||
knRykdilpydktrvkl.........................................kgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWr

MVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRLQ-TETNTCPQFVTSKLLISCGDDD--IREITHLWWRAWPDQGVPETADGIFPFIN
|||. |..|||| |.|.|.. .||..|||.. ..|. |||. ..|.  |.. . .....|| ..  ...   ||...|.. .|||.||||...... .|.
mvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlir

TARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLE
  .   ... ||.||||||||||||.|. .|| ..| .. . ||.|. |.. |.||  .||.  ||.... ..||
kvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 32-178 1.6e-19 64.9 In-house 51-165 (350) alignment 
Range on Protein: 32-178
Range on HMM: 51-165/350.0
NRYFNILPNNHTRFVPASPTKIAdmginlsmttppqtqlvptrspspclS---------CrvllprigdderteYINANFISGY----GPRAMDRYIATQ
||| |||| .|.|       | .                                                   |||||...         .  .|||||
nrYknilPYehsrvkLkkslkss..........................dakkhslstnD..............YinanYlkltrfsveinpdfkYiatq

GPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQdvgtsVVYGDYVIRLQTE
.||| |.  |.... . | .||.. |..||.|  ||.|||..       | |. ..|.  
aPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqe.....gsydditvklask
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 32-178 3.4e-16 53.5 In-house 52-168 (349) alignment 
Range on Protein: 32-178
Range on HMM: 52-168/349.0
NRYFNILPNNHTRFVPASPTKiADMGINLSMTTPPqtqlvptrspspclscrvllprigDDERTEYINANFISGYGPRAMDRYIATQGPLPHTILAFWRM
||| .||| .|.| .     | .  .|. | ..                               .|||||...     .  .||||| ||| |.  |...
nrykdilPyehsrvklkkslk.sskvikastsesd........................sgklddyinanylkltrisvekkyiatqaPlPstvddfykv

VWESKTHVIVMSTDLVENNAVKCERYWPQdvgtsVVYGDYVIRLQTE
.   . ....  .|  |..  ||..|| .       | .. ..||  
illngvklvlsLnddkelslekcdiywqe.....lsysnitvklqns
subfamily_CG42327_pd Subfamily CG42327 77-229 1.3e-33 111.0 In-house 38-190 (319) alignment 
Range on Protein: 77-229
Range on HMM: 38-190/319.0
SPCLSCRVLLPRIGDDERTEYINANFISGYGpRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGT--SVVYGDYVIR
 |    || |.|||||...||..|... ||   |   |||.| .|  .  .|||.||| .. |||  ||| |.   .| .|.|   .     .|||. . 
vPlPetrvvlqrigdddkdeyldasyvrGyd.dapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvt

LQTEtNTCPQFVTSKLLISCGD-DDIREITHLWWrAWPDQGVPETADGIFPFINTA
|.   ..  ....| ||.   | .  ||.|| |.  |.. .||     ..  .  .
lkgr.evkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllev
0051299 (Phosphotyrosine protein) phosphatases II 78-304 1.4e-77 256.3 In-house 60-286 (288) alignment 
Range on Protein: 78-304
Range on HMM: 60-286/288.0
PCLSCRVLLPRIGDDERTEYINANFISGYGPRAMdrYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQdvGTSVVYGDYVIRLQT
|. ..|| |  ....| . ||||..|.||       .||||||||.|.  ||||||| ...|||| |.|||.. .||..|||.  |.|..|||....|  
pydhsRVkLsvldgvegsdYinAsyidgynlkrk..fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtlls

ETNtCPQFVTSKLLISC-----GDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDI
|.  .. ... .| ..      ||.  |..||... .|||.|||.... .. |.. .|..    |||.||||||||||||.|| .|. ..|... |.||.
eev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdv

LSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYM
|. |.. |.||  .|||| ||.... .||||.
leavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 78-305 3.2e-76 251.7 In-house 39-275 (284) alignment 
Range on Protein: 78-305
Range on HMM: 39-275/284.0
PCLSCRVLLPRIGDD-ERTEYINANFISGYGP---RAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDvGTSVVYGDYVI
|  ..|| | ....| | ..||||....||.    .   ..||||||||.|.  ||||||| ...|||| |.||||. .||..|||.. |....|||. .
pydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple.gevltygdftv

RLQTETNtCPQFVTSKLLISCG--DDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVAD--EEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELG-
.|  |.. .. ... .| ...   ..  |..||... .|||.|||.... .. |....|.. .  . ||||||||||||||||.|| .|. ..|... | 
tllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekegl

--VVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYMR
  .||.|. |.. |.||  .|||. ||.... .||||..
llgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
0040438 (Phosphotyrosine protein) phosphatases II 78-306 3.6e-75 248.5 In-house 54-278 (317) alignment 
Range on Protein: 78-306
Range on HMM: 54-278/317.0
PCLSCRVLLPRIGDDERTEYINANFISGYgpRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQdvGTSVVYGDYVIRLQT
|. ..|| |  .| |. . ||||....|.  .  ...||||||||.|.  ||||||| ...|||| |.|.|.. .||..|||.  |....|||....|. 
pydhsRVkLsplggdldsdYInAsyvdgp..nlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtlls

ETNtCPQFVTSKLLISC-GDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNV
|.  .. ..  .| ..  ||.. |..||... .|||.|||.. | .. |.. .|.. ...|||..|||||||||||.|| ... ..| .. | ||. . |
eee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeav

CKTRRQRGLSVQTPVQYVYIHFVLLEYMRQ
.. |.||. .|||| ||.... .||||.. 
kelreqRpgavqtpeqyrflydalleylkr
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 78-305 1.6e-68 226.1 In-house 59-284 (319) alignment 
Range on Protein: 78-305
Range on HMM: 59-284/319.0
PCLSCRVLLPRIGDDERTEYINANFISGYGPRamDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDvgTSVVYGDYVIRLQT
..  .|| |. . . | ..||||.|| ||  |  ...||||.|| .||  ||||||| .....|| |.|||.  ||...|||.   . ..|| ... |. 
aydrtrvvlseldgvegsdyinasfidgyqer..ekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpee..nfeeyGrlivtlee

ETNTcPQFVTSKLLISCGDDDI--REITHLWWRAWPDQGVPETADGIFPFINTARDVADE-EGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILS
| ..  ... .|| .    ...  ||..|  . .|||..|||.| ..  ...  |   .. . ||||||||||||||| || .|. ...  | ||.|. |
eeel.edyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfs

NVCKTRRQRGLSVQTPVQYVYIHFVLLEYMR
 | ..| || . ||.| || .|. .|||.. 
tvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 78-305 9.8e-51 167.4 In-house 54-277 (515) alignment 
Range on Protein: 78-305
Range on HMM: 54-277/515.0
PCLSCRVLLPRIGDDERTEYINANFISGYGprAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRLQt
|  | || |  | |.   .|.|| .| ..   .   |||.|||.. ..  |||.|.. ..  |.| |.| |.. .|| .|||.  | || .| . . |  
PydsvrvklevindnPhsdyfnasyipsfd..ndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelv.

ETNTCPQFVTSKLLISCGDDdIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVC
 ...| . .  || .  ||| .| .|   .  |||.|||. .  .. .|   .   ..   |...|||||||||| .| ||  . .  .  .||..  | 
sleactggikrkltvlkgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvt

KTRRQRGLSVQTPVQYVYIHFVLLEYMR
. |..|   |||  || .|. ..||.. 
nirqkrpylvqtqeqyafiygavledll
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 78-305 1.2e-50 167.2 In-house 55-278 (315) alignment 
Range on Protein: 78-305
Range on HMM: 55-278/315.0
PCLSCRVLLPRIGDDERTEYINANFISGYGprAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRLqT
|  | || |  | |.   .|||| .| ..       |||.||||. ..  |||||...|.  ||| |.. |.. .|| .|||.  . || .| . . |  
PldsarvkleviddsPdsdyinasyiksvd..ddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvel.l

ETNTCPQFVTSKLlISCGDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVC
..... . |. || .    .. | .|   .. |||.||.. .  .. .|   .   ...  ...||||||||||| .| ||  ..|  .  .||..  | 
sleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvk

KTRRQRGLSVQTPVQYVYIHFVLLEYMR
. |..|   |||  .| .|. ..||.. 
nlrakrpylvqteeeyafiydavledll
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 78-307 3.2e-44 146.2 In-house 62-287 (297) alignment 
Range on Protein: 78-307
Range on HMM: 62-287/297.0
PCLSCRVLLPRIGDDERTEYINANFISGYGPramdRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAvKCERYWPQDVGTSvvYGDYVIRLQT
|  | || |  ..||   .|.|| |. |.      |.|.|| | . |.  ||.||.. .. .||| .|. |..  || |||...  |.  .|| .. |..
PydssRvkLaivnddpdsDyvnasfvkgnkh....rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvlls

eTNTCPQFVTSKLLISCGDDDIREI-THLWWRAWPDQGVPE--TADGIFPFINTARDVADEEGG-PIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDIL
 .. .  |.  .| .. |.   | .     .  |||. |..  .|  .  .|.  |.. ...   |..|||.||||||| .. ||  . .  .   |||.
.vsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdif

SNVCKTRRQRGLSVQTPVQYVYIHFVLLEYMRQN
  | | |..|   |||  || ... ..||..  .
glvkklrqerpylvqtkeqykfvyvavleallse
0049772 (Phosphotyrosine protein) phosphatases II 78-306 1.3e-36 122.3 In-house 56-282 (314) alignment 
Range on Protein: 78-306
Range on HMM: 56-282/314.0
PCLSCRVLLPRIGDDErTEYINANFISGYgpramDRYIATQGPLPHTILAF----------WRMV--WESKTHVIVM---------------------ST
..  .|| ||. . .  . ||||....|.      ..|||||||..|.  |          ||||  .. ....|||                      .
lpadnrvilpglpvsg.sdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpll

DLVENNavkcerywpqdvgtS----------VvygdyvirlqtetntcpqF-------VtsklliscgdddIREITHLWWRAWPDQGVPeTADGIFPFIN
.| .|.              .                                     .             |.. ....  .|| ..| . . .  |..
ildgng..............neptaadlellk..................eelydpelf............erlgikylripvpDgsap.lledfdefle

TARDVadEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDElGVVDILSNVCKTRRqRG---LSVQTPVQYVYIHFVLLEYMRQ
  ...  ..|||..|||.||.||||.|. ... | ...   . ..|. | ..|   .    ..... ||..|. .||||.. 
fieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp.inpnpgfieqleqyefilealleylkf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 78-303 3.5e-36 119.3 In-house 47-268 (281) alignment 
Range on Protein: 78-303
Range on HMM: 47-268/281.0
PCLS-CRVLLPR-IGDDERTEYINANFISgyGPRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRL
|||   || |   . . . |.|| ||.|    |     || ||||   |   ||||.|. .|  |||  ...| |  ||  |.|..    . .  . .  
pcldisrvqlkvkmpnknstdyihanyir..spflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsy

QTETnTCPQFVTSKLLISCgDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDvadeEGGPIVVHCSAGVGRTGCFINIDIGMQQWD-ELGVVDILS
.  |     .||..| .|  . . | |||  |. |||  |||... ..  .   |        | |.||||||||.| .. ..| .|     . . ||  
edst.vnkslvttrlnlsy.egetrlithwlwkewpdwqvpessevmlkilrkira....rstppvihcsagvgrsgtlmaveialqsihshftlpdikq

NVCKTRR-QRGLSVQTPVQYVYIHFVLLEY
 | . |   |  ||||  ||. |  |||..
ivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 78-303 2.7e-34 113.2 In-house 56-235 (392) alignment 
Range on Protein: 78-303
Range on HMM: 56-235/392.0
PCLSCRVLLPRIGDDERTEYINANFISGYGprAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNavkcerywpqdvgtsvvygdyvirlqt
|  | || |  | |   ..|.|| .| ..   .   |||.||| . ..  |||||.. ..  |.| |.| | .                           
pydsarvkleviddipdsdylnasyipsfd..nekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........................

etntcpqfvtsklliscGDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVC
                   || | ..   .  |||..||. .  .. ||.  .    .   |...||||||||||  |.||  . .  .  .||..  | 
.................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvt

KTRRQRGLSVQTPVQYVYIHFVLLEY
. ||.|   |||  || .|.  .|| 
nirrkrpymvqtkeqyafiygavled
0044763 (Phosphotyrosine protein) phosphatases II 80-307 1.1e-33 111.8 In-house 3-174 (178) alignment 
Range on Protein: 80-307
Range on HMM: 3-174/178.0
LSCRVLLPRIGDDERTEYINANFISGYgpramdRYIATQGPlphtiLAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGtsvvygdyvirlqtet
  .||||. . . ||..||||..| ..       |.....|      .......| . ..||. |. .|.. .|| .|||.. |                
drtrvllsnleglersdyinaseilpg......lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

ntcpqfvtsklliscgdddireITHLWWrAWPDQGVPETADGIFPFINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQwdelGVvDILSNVCKT
                      |..|..  .|| |||.  . .. |..  ... ||.|||..|||||||||.|... ... ...    |. .. . .   
......................iqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielv

RRQRGlSVQTPVQYVYIHFVLLEYMRQN
|..|   |..| |. ... . |... ..
rerRp.ivpnpgqlrqLyefelrllkes
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 80-218 7e-07 22.3 In-house 40-157 (169) alignment 
Range on Protein: 80-218
Range on HMM: 40-157/169.0
LSCRVLLPRIGDDERTEYINAnfisgygpramdryiatqgplphtilafwRMVWESKTHVIVMSTDLVENNAVKCERYWPQdVGTSVVYGDY------VI
   || | |. .|  ..||||                             ||.||. . |||.  |  . |    |.   | .  .|. |..      | 
shtrvklqrvmedlgsdyina.............................rmiwetnasvivvlgdtddknnfwpekedyq.lhpavilgewytdslyvr

--RLQTETNTCPQFVTSKLLISCGDDDIR-EITHLWWRAWPDQGVPET
  .... |.    ..   ..|   |||.  ... | . .||..|||..
tdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqs
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 80-218 1e-06 21.7 In-house 39-156 (169) alignment 
Range on Protein: 80-218
Range on HMM: 39-156/169.0
LSCRVLLPRIGDDERTEYINAnfisgygpramdryiatqgplphtilafwRMVWESKTHVIVMSTDLVENNAVKCERYWPQdVGTSVVYGDY------VI
   || | |. .|  ..||||                             ||.||. . |||.  |  . |    |.   | .  .|. |..      | 
shtrvklqrvmedlgsdyina.............................rmiwetnasvivvlGdtddknnfwpekedyq.lhpavilGewytdslyvr

--RLQTETNTCPQFVTSKLLISCGDDDIRE-ITHLWWRAWPDQGVPET
  ... .|.    ..   |.|   |||. | .. |   .||..|||..
tdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqs
subfamily_PTPRD_pd Subfamily PTPRD 81-306 6.1e-80 264.4 In-house 62-283 (564) alignment 
Range on Protein: 81-306
Range on HMM: 62-283/564.0
SCRVLLPRIGDDERTEYINANFISGYGprAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDvGtSVVYGDYVIRLQTETn
..|| | ..  || ..||||.|| ||   ..  ||||||||..||  ||||||| ....||| | |.|.. |||..|||.. | .  ||.... |. |. 
hsRVvLskvegdegsDYINAsfidgyr..krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeee.

TCPQFVTSKLLI-SCGDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKT
.  ...  .. .    ... ||...  . .|||.||||.| ..  .|.. |... .. |||||||||||||||.|| ||. ...  | ..||| . | . 
eladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkal

RRQRGLSVQTPVQYVYIHFVLLEYMRQ
|.||   |||. ||..|| ..||..  
rkqRnamVqteeQYiFiheailealac
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 81-306 1.4e-66 219.2 In-house 34-266 (270) alignment 
Range on Protein: 81-306
Range on HMM: 34-266/270.0
SCRVLLPRIGDDERTEYINANFISGYGPRAMDrYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRLQTETN
  || |... .|..|.|||||.. |.  .    |||..|||| |. .||||.||.|.. ||| |.|.|..  |||||||......| . |  |.  ....
atRvrleeleedsataYinAnyvrGfdgekkk.YiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalse

TC-PQFVTSKLLIScGDDDIREITHLWWRAWPDQGVPETAD------GIFPFINTARDVADEE--GGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVD
.    ... .| .   . ..|...| |. .|||.|||...|       .   ... | . .|   ..|..|||||||||||..| .||...  .| . ||
ekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvd

ILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYMRQ
.|. . . |..|   ||.|.|| ... ...||...
vlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_PTPN9_pd Subfamily PTPN9 81-306 1.5e-64 212.9 In-house 56-292 (297) alignment 
Range on Protein: 81-306
Range on HMM: 56-292/297.0
SCRVLLPRIGDDERTEYINANFISGYgpRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRlQTETN
. || |... .|| ..||||||. ||  .  . .|||||||..|.  |||||||... |||| | .||.  .|| .|||.. ..|  .||. .. . |..
etrvvlakvdedeasdyinanfvdGy..kqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvs.nveve

TCPQFVTSKLLIS-CGDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDV--------A-----DEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDE
.  ......| |.   ....|..||    .||| |||..|  .. .....|.         .     . .| |||||||||.|||| || .|| ... .|
eeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrlee

LGVVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYMRQ
.|.||.   | . | ||  |.||| ||.. .. .|||  .
vgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 81-306 1.6e-64 212.9 In-house 60-282 (318) alignment 
Range on Protein: 81-306
Range on HMM: 60-282/318.0
SCRVLLPRIGDDERTEYINANFISGYgpRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDvgTSVVYGDYVIRLQTETN
..||.|  . ..| ..|||||.| ||  |.   |||.|.|||.||  ||||||| .. |||| |...|.  .|..||||..   |  ||. |. |. |..
htrvkLqmlegeegsDyinanyidGy..rrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk..gsrsygklvvelkeeve

TCPQFVTSKLLISCGDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVA-DEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKT
.    . .  .   . .. |..    . .|||.|||| . ..  .. ... .  ... ||||||||||||||| || .|| ...  . ..||..  | . 
lsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkql

RRQRGLSVQTPVQYVYIHFVLLEYMRQ
|.|| | |||  ||..|. ||||..  
reqrnlmvqtedqyefiydvllealas
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 81-305 1.1e-59 197.1 In-house 70-291 (298) alignment 
Range on Protein: 81-305
Range on HMM: 70-291/298.0
SCRVLLPRIGDDERTEYINANFISGYGPRAmdRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVgtSVVYGDYVIRLQTETN
|.||.| .. .|| ..|||| |...|  |    .||||.||..|.  |||||.| .  .||| |.|.| . .|...|||..   .  ||.  ..|. . .
ssRvvLekedadeesdYiNAsflhaykgrn..afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdeg..ketygeitvsllskee

TCpQFVTSKLLI-SCGDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEEG-GPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCK
   .... || . .   .. ||. .| .  |||.||||.|  .. ...  |    . |  |..|.|||||||.| || ||  ...  .  |||..  |  
fa.dlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkv

TRRQRGLSVQTPVQYVYIHFVLLEYMR
 |..|  .|||  |||.|. . ||.. 
lRkkrpgavqteeqYvfiyeavleald
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 81-305 3.4e-57 188.5 In-house 23-243 (250) alignment 
Range on Protein: 81-305
Range on HMM: 23-243/250.0
SCRVLLPRIGDDERTEYINANFISGYGPRamDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVkCERYWPQDVgtSVVYGDYVIRLQTETN
|.||.| .   |. ..|||| |. ||  |  . .|||||||..||  |||||.| |. .||| |.|.|.. . ...||| ..  .  |||  . |  . .
ssrvvLekekgdkesdyinasflhgyder..kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek..aekyGdvtvsllskee

tCPQFVTSKLLISCG-DDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADE-EGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCK
    ... || .|     | | . .| . .|||.||||.|  .. ...  .   .. . .|..|.|||||||.|.|| ||  ...  .  |||.   . .
.fadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikv

TRRQRGLSVQTPVQYVYIHFVLLEYMR
 |..|  .|..  |||... ..|... 
lrkdrphavesleqyvfvyeiilkald
subfamily_PTPRK_pd Subfamily PTPRK 81-302 1.9e-56 186.2 In-house 57-275 (314) alignment 
Range on Protein: 81-302
Range on HMM: 57-275/314.0
SCRVLLPRIGDDERTEYINANFISGYgpRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDvgTSVvYGDYVIRLqTETN
 .|| |  | .|  ..||||..| .|  .    .|.|||||..|.  |||.|.. ..  ||| |.|||. .||| .|||.|  |.| |||  . |  ||.
rsrvflitidgdpssdyinaalidsy..krpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed..tev.ygdikvel.vete

TCPQFVTSKLLISC---GDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVC
.  ..|.  . ..    | ..|||. .. . .||| .||  | |.. ..       .|| |.|||||||| ||||.|| ||| ..  .. ||||.   | 
llaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavk

KTRRQRGLSVQTPVQYVYIHFVLLE
. | ..   |.|  ||..|. |.||
tlrsrkvnmveteeqykfiydvile
subfamily_PTPN13_pd Subfamily PTPN13 81-304 3e-53 175.9 In-house 51-269 (273) alignment 
Range on Protein: 81-304
Range on HMM: 51-269/273.0
SCRVLLPRIGDderteYINANFISGYGPRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGD-YVIRLQTET
  || |   |      ||||..|         .|||.|||||.|.  ||.|||| |..||.| |  .|.. |||.||||.  . ...  . . ..|   .
etrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvq

NTcPQFVTSKLLI-SCGDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADeEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCK
.   .|| ..| .      . ||..|| . .||| ||| .|. .  |.   | ... . ||||||||||.||.| .| ||. ..  .    .|.   | |
kl.dgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrk

TRRQRGLSVQTPVQYVYIHFVLLEYM
 |.||   |||  ||.... ..|| .
lreqrqgvvqtkdqyifvykailevl
subfamily_PTPN14_pd Subfamily PTPN14 81-306 2.4e-47 156.4 In-house 63-298 (300) alignment 
Range on Protein: 81-306
Range on HMM: 63-298/300.0
SCRVLLPRIGDDeRTEYINANFISGYGPRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQD--VGTSVVYGDYVIRLQTE
 .|| |    .. .|.||||  |.     .   ||..||||..|.  ||.||||.....||| |.  |.   |. .|.|..     .| .| . .  .  
dnrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfs

TnTCPQFVTSKLLIS-CGDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDV---AD------EEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELG
. . ....|..| .      . |.. || .  |||.||||  .| . ...  . |   ..      |.  |..|||||||||||  |  |. ..  .   
e.dsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehne

VVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYMRQ
..|| . . . |.|| | |||  || ... ||..|...
eidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
subfamily_CG7180_pd Subfamily CG7180 81-307 1.9e-37 123.5 In-house 56-293 (296) alignment 
Range on Protein: 81-307
Range on HMM: 56-293/296.0
SCRVLLPRIGDDERTEYINANFISGYGPRamDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAvKCERYWPQDVgtSVVYGDYVIRLqTETN
  ||.|.... .|...|||| .. ..       || |..|  .|. .|||.|.. ... .|. |.  . .  ..  |||..      ||. .. . .|..
ynRvvLekldGeeksdYinavyvdsflkk..keyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqygeifvei.veek

TCPQFVTSKLLISCG-----------DDDIREITHLWWRAWPD-QGVPETADGIFPFINTARDVADEE-----GGPIVVHCSAGVGRTGCFINIDIGMQQ
. ..... .. .              . . | .... .. |.  . ||  . ..  ... .| . ..       ||.||..| |..|.| .. ||. ...
qyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlel

WDELGVVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYMRQN
 .. . ||.   | . ||.|   |..  .| ||  ||||..  |
vekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn
subfamily_ptpA1_pd Subfamily ptpA1 81-265 4.4e-35 116.2 In-house 61-257 (418) alignment 
Range on Protein: 81-265
Range on HMM: 61-257/418.0
SCRVLLPRIGDDERTEYINANFISGYGPRamdRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTS---------VVYGDY
  || | .| | | ..|||||.| |  |.   ..|.|||||| ||  ||||||| . ..||| .   ||  .||.||||...|            |.| |
htrvqlkkiqdkegsdyinanyidgaypk...qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgty

VIRLQTETNTCPQFVTSKLLISCGDDDIREITHLWWRAWPDQGVPETADGIFPFIN----TARDV--ADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWD
 . |    .   . . .. .    . . |.||.  .  |||. .|. .. .  ..        ..  . .   ||.||||||||||| |    | |.. |
svelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkld
subfamily_PTPRB_pd Subfamily PTPRB 82-309 3.2e-73 241.3 In-house 66-290 (293) alignment 
Range on Protein: 82-309
Range on HMM: 66-290/293.0
CRVLLPRIGDDERTEYINANFISGYgpRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVgTSVVYGDYVIRLQTETNt
 || |  . |.. ..|||||.|.||  ...  .||||||||.|.  |||||||.|...||| |.|||.  ||||.|||.|  ..|.|||  . |..|.. 
srvkLaalkdesgsDYinanyipgy..nsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeee.

CPQFVTSKLLISCgDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVA--DEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKT
  ..|. .|.|.  ....|..... . .||| ||||... .  |..| |...  ... .|||||||||||||| || .|  .|. .|  .|||.. |.. 
ledwvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivael

RRQRGLSVQTPVQYVYIHFVLLEYMRQNPR
|..| | |||  ||..|| ..|...|.. .
ReeRnllvqtekqYifihqcvldllrkkee
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 82-307 4.6e-67 221.1 In-house 56-279 (281) alignment 
Range on Protein: 82-307
Range on HMM: 56-279/281.0
CRVLLPRIGDDERTEYINANFISGYgpRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPqDVGTSVVYGDYVIRLQTEtNT
 || . .  ... |.||||||..||  .   .|||||||.|... |||.|||| | ..||| |  .|.. .|| |||| |  ... |||.... ..| ..
trvkvtpneenkntDYinanfvpgy..kgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstae.ee

CPQFVTSKLLISCGDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEEG-GPIVVHCSAGVGRTGCFINIDIGMQQW-DELGVVDILSNVCKT
 ..... |. ..  . . ||...| . ||||.|||.|.  .. | .  . . ...   |.|.||||||||||..| .|  ...  .||  .|.   | . 
katyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvael

RRQRGLSVQTPVQYVYIHFVLLEYMRQN
|..| | ||| ||| ... ..|... ..
rkernlmvqtvvqyefvykavldaldke
subfamily_PTPRA_pd Subfamily PTPRA 82-304 1.8e-62 206.1 In-house 73-295 (330) alignment 
Range on Protein: 82-304
Range on HMM: 73-295/330.0
CRVLLPRIGDDERTEYINANFISGYgpRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDvgTSVVYGDYVIRLQTETNt
 || |. .   | ..|||| || ||  .  |..||.|||. .|.  ||||.|| |.. ||| |.| | .  ||..|||..   .| ||.  . .. ||  
srvilsvkeGveesdyinasfidGy..kekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde..GlvtyGnirvevedetv.

CPQFVTSKLLIS-----CGDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNV
. ..   |.|.      . ... | .. . ...||| ||| .. |.. ...  . . . ..||||||||||||||| || .|  ...    ..||.   |
lvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefv

CKTRRQRGLSVQTPVQYVYIHFVLLEYM
 . | ||   |||  ||..|. ||||| 
krlrlqrpqmvqtdeqyefiykvlleyy
subfamily_PTPN12_pd Subfamily PTPN12 82-307 2.6e-62 205.3 In-house 55-280 (290) alignment 
Range on Protein: 82-307
Range on HMM: 55-280/290.0
CRVLLPRIGDDERTEYINANFISGygPRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRLQTETNT
 || | .| ..|  .||||||| |  .    .|||.|||||.|.  ||||.|| .....||   .||..  |||||||. ..... .|.. . |..| ..
srvelskieeeegsdYinanfikg..vegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekav

CPQFVTSKLLISCGdDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGV---VDILSNVCK
  .|.   | . .  .. |... . ..||||.|||..|. .. .|...|.. ..|  |.||||||||||||  | ||.  ..  .  .   .|. . | .
dddflirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvle

TRRQRGLSVQTPVQYVYIHFVLLEYMRQN
 |.||   |||  ||....  ..|.....
lrkqraalvqtkeqyelvykavaelvqke
subfamily_Ptp69D_pd Subfamily Ptp69D 82-306 1.1e-59 197.0 In-house 63-288 (307) alignment 
Range on Protein: 82-306
Range on HMM: 63-288/307.0
CRVLLPRIGDDERTEYINANFISGYGprAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDvgTSVVYGDYVIRLQtETNT
 || |..|  .| ..||||.|| ||      ..|| |.|.  ||  ||||..| . ..||| ..| | |  ||..|||..  . | ||| ...|  ....
tRvkLkkingkedsdYinasfikgyk..ekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklv.seek

CPQFVTSKLLISCGD------DDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSN
.....  .| .|  .      .| |...   . .|.|  |||.| |.. .|. .|..   . .||||||||||||.| |. .|. .||  .   |||   
hsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifet

VCKTRRQRGLSVQTPVQYVYIHFVLLEYMRQ
|.. |.|| | ||   |||...  ||.|.  
vkdLrsqRnllvqsleqYvflyralldyssy
subfamily_PTPRG_pd Subfamily PTPRG 82-306 2.8e-57 189.2 In-house 62-289 (563) alignment 
Range on Protein: 82-306
Range on HMM: 62-289/563.0
CRVLLPRIGD-DERTEYINANFISGYgpRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQdvGTSVVYGDYVIRLQTETN
 || |  . . ... .|||||.| ||  .  . .|||||||..|.  ||||.|| ....||| |.|||... ||..|||.   .|. ||   ..|..|  
sRvklsplpgkkkklDYinAnyidGy..qkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeev

TC----PQFVTSKLLISCGDD--DIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILS
..     ..|  .| .  ...  . .....  .  |||.|||| .     |.. .     .| ||||||||||||||| .| .|  ..|  .  .|... 
lalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfg

NVCKTRRQRGLSVQTPVQYVYIHFVLLEYMRQ
 . . | ||   |||  ||...| .||| .. 
flkhiraqRnflvqteEqYiflhdalleaias
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 82-303 3.4e-54 178.9 In-house 64-278 (315) alignment 
Range on Protein: 82-303
Range on HMM: 64-278/315.0
CRVLLPRIGDDERTEYINANFISGYGprAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDvgtSVVYGDYVIRLQTETNT
 || || .  |. ..|.||||| ||     .||||.|||.. ..  |||.|.| .   ||| |.|||..  |.|.||| .    |.|| . . .. |   
srvqlpllendphsdyvnanfidGyn..kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevn

cpQFVTSKLLISCGDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRR
  . .| . |    .|.|||.  | . .||| |||. .  .  .| |..   ... |.||||||||||||| || .|  ..| .   ..|.   . . |.
..teytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrq

QRGLSVQTPVQYVYIHFVLLEY
.|   ||.  || .|. .||| 
nrikmvqvaeqyqfiydallet
subfamily_PTPN23_pd Subfamily PTPN23 82-306 7.9e-47 154.4 In-house 58-282 (288) alignment 
Range on Protein: 82-306
Range on HMM: 58-282/288.0
CRVLLPrigdDERTEYINANFISGYGPRAmDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRLQTETNT
 || |     ... .|||| |. .  | .   .||||.||. |.  ||.||.| |. |||| ..  | .  |..||||.| | .|..||. . |. ...|
nRvklr....gskDDYinAsfvkdlspgc.PdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvret

cPQFVTSKLLISCG-DDDIREITHLWWRAWPDQGVPETADGIFPFINTARD----VADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWD-ELGVVDILSN
 ...|  .| ..    | .....|| . .||. |||.. . .. |.. ...    |  .   |.|||||||||||| |  .   ... . . |..||.  
.ethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqv

VCKTRRQRGLSVQTPVQYVYIHFVLLEYMRQ
| . |.||  .||.  |.     . ||. |.
vsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 82-309 5.4e-46 151.7 In-house 53-282 (287) alignment 
Range on Protein: 82-309
Range on HMM: 53-282/287.0
CRVLLPRIGDdERTEYINANFISGYgpRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDvGTSVVYGDYVIRLQTETNT
 ||||   |.   ..|||||....|  .  ...||.|||.. |.  |||.|.| .. .... |  ||.   || .|||.     .  | | . |   .. 
trvllsaege.lGsdyinanyvasy..tddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvGGysvvlldydik

CPQFVTSKL-LISCGDDDIREITHLWWRAWPDQGVPETADGIFPFINTA-----RDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSN
 |.. .  | ||     . | .  | . .|||.... || |.  |.             .| ||.|||...|.||.| .... . ...  .|| ||.   
ePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaav

VCKTRRQRGLSVQTPVQYVYIHFVLLEYMRQNPR
| . | .|   ||..||. ..   |  | . ||.
virlreyraalvqavvqlrllyealvtyyktnpq
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 82-306 2.2e-43 143.6 In-house 63-290 (325) alignment 
Range on Protein: 82-306
Range on HMM: 63-290/325.0
CRVLLPRIGDDERTEYINANFISGYgpRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLvENNAVKCERYWPQDVGTSVVYGDYVIRLQTETNT
 || |   .||  ..||||...  .  .  | ..|.| ||..||  .||.| . .. |.|.   | ...  .|  |||...| |. .|   ..|.|  . 
srvvletkkddpssdyinasylrdd..kkkdvflaaqaPltatindlWrlvldWrcsvvvvlnel.dlgkdrcavywpkemgksktfGglevklrtieei

cPQFVTSKLLISCGDDD-IREITHLWWRAWPDQGVPETADGIFPFINTARDVAD------EEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILS
   .|  .| .   ..   | .  . ...|.| ||..    . .....   | .      .  .||.||||||||||| || .   ...  |   |||. 
.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifg

NVCKTRRQRGLSVQTPVQYVYIHFVLLEYMRQ
 | | |..|   |.|  ||. |.  | |..  
fvkklrkdrpsmvetvdqyiliyealveayms
subfamily_PTPRN_pd Subfamily PTPRN 82-298 1e-42 140.9 In-house 71-286 (297) alignment 
Range on Protein: 82-298
Range on HMM: 71-286/297.0
CRVLLPRIGDDERTEYINANFISGYGPRAmDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDvGtSVVYGDYVIRLQTETNT
 || | .  ..|...|||| .|    |||   ||||||||..|. .||.||||. . |||. | | |..  .|.||||.. | | ||. | ..| .|   
srvklkeeasaeksdyinasaildhdpra.payiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpde.G.sevyhiyevhlvsehiw

CPQF-VTSKLLISCGDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWD-ELGVVDILSNVCKT
| .. | |  |     .. | .| . . .||..||| .|  .. |             |||||||.|.||||..| ||. ...    .  .|| . . . 
cddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehl

RRQRGLSVQTPVQYVYIHF
| ||   |.|  |. ..  
rdqrpglvktkdqfefalt
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 82-302 3.2e-40 132.8 In-house 22-238 (239) alignment 
Range on Protein: 82-302
Range on HMM: 22-238/239.0
CRVLLPRIGDDERTEYINANFISGYGPrAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDvgTSvVYGDYVIRLQTeTNT
 ||.| .. .| ...||||...  |   .   |||||| .  .   ||||.|. .  |||| | |.|    || .|||.   ||  | .  . |.  |. 
srvvleklsndphsdyinasylrdydg.spkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds..ts.kycnlrvtlrk.tev

CPQFVTSK-LLISCGDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTR
  ...    ..   |. . | . .  .  |||.|||. |  .. .       .     | |.||||||||||.|. ||  ..|  .   |||.  |   |
fadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkair

RQRGLSVQTPVQYVYIHFVLLE
 .|   |||  |||.||. .||
edrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 82-302 4.3e-40 132.4 In-house 23-239 (239) alignment 
Range on Protein: 82-302
Range on HMM: 23-239/239.0
CRVLLPRIGDDERTEYINANFISGYGPrAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDvgTSvVYGDYVIRLQTeTNT
 ||.| .. .| ...||||...  |   .   |||||| .  .   ||||.|. .  |||| | |.|    || .|||.   ||  | .  . |.  |. 
srvvleklsndphsdyinasylrdydg.spkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds..ts.kycnlrvtlrk.tev

CPQFVTSK-LLISCGDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTR
  ...    ..   |. . | . .  .  |||.|||. |  .. .       .     | |.||||||||||.|. ||  ..|  .   |||.  |   |
fadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkair

RQRGLSVQTPVQYVYIHFVLLE
 .|   |||  |||.||. .||
edrphmvqtseqyvfihlavle
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 82-304 1.1e-24 82.1 In-house 33-259 (290) alignment 
Range on Protein: 82-304
Range on HMM: 33-259/290.0
CRVLLPRIGDDERTEYINANFISGygPRAMdRYIATQGPLPHT-------ILAFWRMVWESKTHVIVMSTDLVENNAV----KCERYWPQDVGTSVVYGD
 || |   |     .|| ||...   |  . | |.|| |. ..       |  || |. . | . .||  .  |..|      |..| |. ||... ...
trvvLkgygkrfnddyiHAnrvtc..pngl.rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg

YVIRLqTETNTCPQFVTSKLLISCGDDDIREITHLWWRAWPDQGVPETADGIFPFINTardVAdEEGGPIVVHCSAGVGRTGCFINIDIGMQQWD-ELGV
  ..  ..  .  .. | .|..  .|.    .|| . . | .  |.|.   .   |..   |   .. |..|||  |. |  ..  |..|.|      | 
ltvkC.kskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqk...vk.asktpvivHcvdGiSrsAalaaiilgyQkiaetsgs

VDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYM
| . . . . |.|| | .... .. ..  ... ..
vkledvlkalrkqralaitsalelafvdagivlla
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 83-309 2.2e-65 215.6 In-house 63-284 (288) alignment 
Range on Protein: 83-309
Range on HMM: 63-284/288.0
RVLLPRIGDDERTEYINANFISGYgpRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDvGTSVVYGDYVIRLqTETNTC
|| |    . . ..||||..| |.  . . .||||||||..|.  ||..|.| ||. ||| |.|||..  |||.|||.. .. . ||.  . | .|... 
rvklkkleeeagaDYinasyidge..kkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPda.dkpknyGsvtvtl.veskel

PQFVTSKLLIScGDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQ
 .||. |||.   . . .|||.. . ||||.|||| .  .. ....     ... |||.||||||||||| || .|  ... .|  ..|... |.| |.|
edfvlrkllle.kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkq

RGLSVQTPVQYVYIHFVLLEYMRQNPR
| | |||  ||..|. |||. . .. .
RallvqtlkqYefiyevllslieedgv
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 83-304 3.4e-64 211.9 In-house 62-283 (305) alignment 
Range on Protein: 83-304
Range on HMM: 62-283/305.0
RVLLPRIGDDERTEYINANFISGYgpRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRLQTETnTC
|. |    ... ..||||... ||  .  ..||..||||..|.  |||...| |...||| |.|||..  ||..|||. .. .. .|.... |. |. | 
riiltekeslddsdyinasyvdgy..krkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksek.ta

PQFVTSKLLISC--GDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEE-GGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKT
..... || ||   .|.. | ....    |||.|||..|  .  .|.  .    .. | |..||||||||||| || .|| ...  . .|||.   . . 
sdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkql

RRQRGLSVQTPVQYVYIHFVLLEYM
|..|   |||  |||..| .| |..
RskrmkmvqtldqYvflhdaldeli
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 83-302 1.1e-52 174.3 In-house 77-289 (319) alignment 
Range on Protein: 83-302
Range on HMM: 77-289/319.0
RVLLPRIGDDERTEYINANFISGYgpRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTdlvennAVKCERYWPQDVGTSVVYGDYVIRLQTETNTc
.| | |.   | ..|||| |..||  .  |.|||.||||. |.  ||||.||...  ||. |        || .|||...      ..  . . .||.  
vvklerliGeefsdyinasfvtGy..qrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetae.

pqFVTSKLLISC--GDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEEGG--PIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCK
  .|  .. .|      |||.||   .. |||.|||. .  .. ...  | . . | .  .||||||||||||| .| .|. ... .|   ||.   |  
..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrd

TRRQRGLSVQTPVQYVYIHFVLLE
 |.||   ||  ||| .|.  |||
lrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 83-302 2.5e-52 173.2 In-house 41-253 (284) alignment 
Range on Protein: 83-302
Range on HMM: 41-253/284.0
RVLLPRIGDDERTEYINANFISGYgpRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTdlvennAVKCERYWPQDVGTSVVYGDYVIRLQTETNTc
.| | |.   | ..|||| ||.||  .  |.||||||||. |.  ||||.||...  ||. |        || .|||...      ..  . . .|..  
vvklerliGeefsdyinasfitGy..qrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveesee.

pqFVTSKLLISC--GDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEEGG--PIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCK
  .|  .. .|      |||.|.   .. |||.|||. .  .. ...  | . . | .  .||||||||||||| .| .|. ... .|   ||.   | .
..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrd

TRRQRGLSVQTPVQYVYIHFVLLE
 |.||   ||  ||| .|.  |||
lrqqrntlvqdlvqykfiysalle
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 83-306 5.8e-52 171.3 In-house 62-285 (290) alignment 
Range on Protein: 83-306
Range on HMM: 62-285/290.0
RVLLPRIGDD--ERTEYINANFISGYgpRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDvGTSVvYGDYVIRLQTETN
|. | .|...     ||||| .| ||  .   .|||||||...|.  ||...|. |. .||| |. .|.. |||  |||.  .|.  || . |.|. |..
ritLrpisghkDCtneyinAcyikgy..kekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikllneet

TCpQFVTSKLLISCGDD--DIREITHLWWRAWPDQG-VPETADGIFPFINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVC
.  .... || .   .   . ...|..   .|...| |....  .  . .  .    .  ..||||||..|||.. |. .......    ||.|... . 
ln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlk

KTRRQRGLSVQTPVQYVYIHFVLLEYMRQ
. | |.  |||| .|| .|. ..|.|. .
sqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 83-305 4.4e-50 165.3 In-house 63-279 (287) alignment 
Range on Protein: 83-305
Range on HMM: 63-279/287.0
RVLLPrigdDERTEYINANFISGYgpRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDvgTSVVYGDYVIRLQTETnTC
||||     .|. .|||| || ||  .   ..|....|. .|.  ||..... . ..||| ... ||.  .| .|||..  .|||.|.| |.|  |. . 
rvllk....gehpdyinavfidgy..kekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpee..ksvvlGeyniellnee.vn

PQFVTSKLLISCG--DDDIREITHLWWRAWPDQG-VPETADGIFPFINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKT
 ...  || .     ..| ....     .|...| |.| .  .. . .  .    .  ..||||||..|||.. |. ....... .. ||.|... . . 
agyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksq

RRQRGLSVQTPVQYVYIHFVLLEYMR
| |.  ||||  || .|  ..|||. 
riqkpgsvqtveqykfindivleyld
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 83-302 8e-46 151.2 In-house 19-237 (237) alignment 
Range on Protein: 83-302
Range on HMM: 19-237/237.0
RVLLPRIGDDerTEYINANFISGYGPrAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQdVGTSVVYGDYVIRLQTETNTC
||.|   | .  ..||||... |.   .  .|||.||||  .   ||.|||. |  |||| | |.|.| .|| .|||.       || . . |. . . .
rvvlkgagsg..sdyinatylkgfdg.tpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywps.tdqpaaygvltvslkkkeefs

PQFVTSKLLISC-GDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADE--EGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKT
   | | ||       ..| |    . .|||.|||. .  .. |     . .    | || ..|||||||||| |. ||  ..|  |  ||||   |   
dytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysi

RRQRGLSVQTPVQYVYIHFVLLE
  .|   .||  |||.|| ..||
eedrpyiiqtkdqyvfihqtile
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 83-304 1.2e-43 144.2 In-house 64-279 (439) alignment 
Range on Protein: 83-304
Range on HMM: 64-279/439.0
RVLLPRIGDDERTEYINANFISGYGPRamDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAvkcerYWPQDvgTSVVYGDYVIRLQTETNtC
|| |  |     . |||||.| ||     . |||||||  .|   |||.|.| ||  ||| |.|||        ||| |  . |.||| ..| . . .  
rvtlqeipgvphshyinanyikGyydd..klyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsd..aevcygdiavrvdrnie.l

PQFVTSKLLISCGDD---DIREITHLWWRAWPDQGVPETADGIFPF---INTARDvaDEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNV
|..|   . .    |     | . .. . ||||. ||  |  .  |   ||.| |  .|| ||.||||||||||||  | .|| ..|      |||   |
pnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsand..keeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgiv

CKTRRQRGLSVQTPVQYVYIHFVLLEYM
   |.||   ||. .|||.|.  .|| .
kvlrkqrkqmvqalcqyvfiynavledi
0046846 (Phosphotyrosine protein) phosphatases II 88-305 8.7e-39 128.4 In-house 5-174 (176) alignment 
Range on Protein: 88-305
Range on HMM: 5-174/176.0
RIGDDERTEYINANFISGYgpramdRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVvygdyvirlqtetntcpqfvt
..|.|.   |||||.| |.      |.||||||||.|. .|..|..| . ...|. |..|| . .|| .|||.  . ..                     
llgldldldyinanlilgs......rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

sklliscgdddireitHLWWRAWPDQGVPETaDGIFPFINTARDVADEeGGPIVVHCSAGVGRTGCFINIDIGMQQwdelGVVDILSNVCKTRRQRG-LS
                . ..  ||| |||.  . .. ...  |.. .| |||..||||||.||||... ... . .      ....  ... |.||   .
................qylhlpwpDhgvpdl.elllellefirealke.ggpvlVHCsaGigRtgtlvaayllele....kglsveealalvreqRplga

VQTPVQYVYIHFVLLEYMR
|||| || ... ..|....
vqtpeQyrflyefellllk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 88-306 3e-32 106.4 In-house 72-292 (310) alignment 
Range on Protein: 88-306
Range on HMM: 72-292/310.0
RIGDDERTEYINANFISGYGPRamDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQdVGTSVVYGdyVIRLQTETNTCPQ---
.|      .|| ||..     |  . .| .|||| |||. ||||... ..  |..    .|.   ||  |||  .| .  ||  .||.   ...  .   
kidksryedyihanyvktnylr..stficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps.lgvtetyg..cirvtnlsesseefei

------FVTSKLLISCGDDDIRE--ITHLWWRAWPDQGVPETADGIFPfintARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNV
      ||  .. .     ...|  .. . |  |||.|||.      |     | .|.   || |||||||..|... ..... ... |.   ||.   .
cnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp....qrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevk

CKTRRQRGLSVQTPVQYVYIHFVLLEYMRQ
 . ...|   .||..||..|..| . . | 
tellksraiciqtelqyliidrvriifarg
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 88-306 5.7e-32 105.9 In-house 61-273 (288) alignment 
Range on Protein: 88-306
Range on HMM: 61-273/288.0
RIGdDERTEYINANFISgyGPRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRLQTETNTCPQFVT
..  |.   ||.|| .|    .   | | .| ||  ||  .|.|. ||  . ||| ..|.|    | . |.|  .| .. .| .    . . .   . |.
kls.ddpdfyiaanvvs..sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvk

SKLLISCGDDDIRE-ITHLWWRAWPDQGVPETADGIFPFINTArdvaDEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLS
  ||      . .  . .| .. |.|.||||     . ...       .   |||||.|||||||| .| | | ...      . | | . | | .|  .
vsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfka

VQTPVQYVYIHFVLLEYMRQ
.||  ||.|.| ..||.. .
iqtemqylyvhrcvleelll
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 90-306 1.3e-40 133.9 In-house 76-285 (290) alignment 
Range on Protein: 90-306
Range on HMM: 76-285/290.0
GDDERTEYINANFISGYGPraMdrYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRLQTETNTCPQfVTSK
 |    .|. ||.. |  .  |  .| |||.|  |.. .|||| . |. .|||  .|.|.   |||.|.|.  |  . .|.. .    |..   . .  |
kdGydGdyvhanyvkGlka..m..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdan.iikk

LLISCGDDD--IREITHLWWRAWPDQGVPETADGIFPFINTARDVAdeegGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLSV
.|     |.     . ||  ..|||. |. ..  ..  . . | ..    ||.|||||||.|||| |. |..|.|   .   .|.|  |   |. |  ||
tlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkas....GpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsv

QTPVQYVYIHFVLLEYMRQ
|  .||. .  .||.. ..
qvdiqylalveilldlGkd
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 91-307 2.5e-42 139.6 In-house 66-296 (301) alignment 
Range on Protein: 91-307
Range on HMM: 66-296/301.0
DDERTEYINANFISGYgpRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRLQTEtNTCPQFVTSKL
|  ..|||||..|.||  .   ..||.|||. .|.  |||..|. |.  ||| |.| |.   |||.|||.   .|  .|   . |. | .. |.||  .|
dlcqreyinasyidgy..sekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvne.qvyPdfvirql

LISCGD----------------DDIREITHLWWRAWPDQGV-PETADGIFPFINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDIL
 .   |                 . .... |    ||..|| .| .  .    .        .|||.|||||..|.|.| .. ..||. |    ||||. 
nvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvf

SNVCKTRRQRGLSVQTPVQYVYIHFVLLEYMRQN
  .   ||..   |.|  ||. |. |. .|.. |
qvtkavrrskpgaVtTLeqytsiydvidmylqln
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 91-307 1.4e-36 120.7 In-house 76-292 (305) alignment 
Range on Protein: 91-307
Range on HMM: 76-292/305.0
DDERTEYINANFIsGYGPRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSV-VYGDYVIRLQTET---NTCPQFV
.   ..|| ||.. |       |.|..|||| .||  || || . |   |||    ||   .|| .|||   |  . . .  |.   . .   .  ..  
kpspsdyihanyv.gcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiq

TSKLLISCGDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVAdeegGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKT-RRQRGL
 . | ..   |.   . || |  |||.|||      . .. . |        |||||||||.||||  . |.  ...  |   .  . .. |. | ||  
itllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk....vpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqraf

SVQTPVQYVYIHFVLLEYMRQN
|.|. |||..|| |.|.|. ..
siqndvqylfihrvmlnyflek
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 91-154 1.4e-06 22.1 In-house 56-118 (332) alignment 
Range on Protein: 91-154
Range on HMM: 56-118/332.0
DDERTEYINANFISGYGPRAmdRYIATQGPL-PHTILAFWRMVWESKTHVIVMSTDLVENNAVKC
.| . .. ||... ||  ..   || .| |.  ||   ||||| | |  .|..  |. |..  |.
qdgkddfynaswvdgyskks..ayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_PTPN3_pd Subfamily PTPN3 92-297 1.8e-55 182.8 In-house 62-268 (280) alignment 
Range on Protein: 92-297
Range on HMM: 62-268/280.0
DERTEYINANFISGYGPR--AMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQdVGTSVVYGDYVIRLQTEtNTCPQFVTSK
...|.|||||...   |   .. |||||||||..|   ||.|||| |...||| |.|||.  ||| .|||.  . .. ||.. .... | ..  ..|. .
esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedeleygefsvkceke.detksyvlre

LLISCGD-DDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLSVQ
|...  . .. |.|..| . ||||.|||. .. .. |... |..   .  |.|||||||.|||| .| ... ..  ..   | .|  | . | ||.  ||
lvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvq

TPVQYVYIH
|. || .. 
tasqykfvC
subfamily_PTPN1_pd Subfamily PTPN1 92-302 7.4e-46 151.2 In-house 53-269 (290) alignment 
Range on Protein: 92-302
Range on HMM: 53-269/290.0
DERTEYINANFISgyGPRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVG-TSVVYGD--YVIRLQTEtNTCPQFVTS
.. ..||||...    ..|  .|| ||||||.|.  ||.|||| |.. .||   .||.. .|| .||||.    .... |  . ..| .| ..  ... .
radndyinaslve..leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvklise.erksyytvr

KLLIS-CGDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDV--ADEEGGPIVVHCSAGVGRTGCFINIDI---GMQQWDELGVVDILSNVCKTRRQ
.| .     .. |||.|  . .||| ||||.    . |.   |.     .. || |.|||||.||.| |. .|     ... |.|  |||   ... |..
llelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrky

RGLSVQTPVQYVYIHFVLLE
|   .||. |  . .. .||
rlGliqtadqlrfsylaile
0043147 (Phosphotyrosine protein) phosphatases II 92-297 9.2e-39 128.3 In-house 2-154 (172) alignment 
Range on Protein: 92-297
Range on HMM: 2-154/172.0
DERTEYINANFISGYGprAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLvennavkcerywpqdvgtsvvygdyvirlqtetntcpqfvtskll
||.. ||||.....|    .||.|||||||..|.  ||||..| . ..||. |.|                                             
degsdyinasyldlyy..ipdrfiatqgplrntladfwrmlkelgithivnltel.............................................

ISCGDDDIREITHLWWRAWPDQGVPeTADGIFPFINTARD-VADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWdelgvvDILSNVCKTRRQRGLSVQTP
   ...  |.. ....  |||.||| ... .  |..  .. .| ..|||..|||||||||||... ... ....      ...  |.  |..|. .||.|
lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylmllgl......sleeavalvrekRpgavqnp

VQYVYIH
 || ...
sqyrfly
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 92-305 2.3e-32 107.1 In-house 54-260 (267) alignment 
Range on Protein: 92-305
Range on HMM: 54-260/267.0
DERTEYINANFISGYgpRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAvkcERYWPQDVGTSVVYGDYVIRLQTETNTC-PQFVTSKL
..  ||||| .. ||  .    .|.||.||  ||  |. .. . |  |||. |   ..|     ..||  .| .  | | ..    | .    | .| .|
tkeeeyinasyvegy..ktknafivtqdplkntitdfltvihdqkvpvivlltkvftdni...rlfwPPkmgqakkyqdltvehslekeendyqiitlel

liSCGDDDIREITHLWWRAWPDQGVPETadGIFP-FINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLSVQT
     ..  ...|  ... |  .   .    . | |   |..  .. . |.||.||.||||.| |. ||  ...  . ||.||   . | | ||   |.|
..kfknesahnvtlyyykkwnintnnkp..ylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdt

PVQYVYIHFVLLEYMR
  .|.||| .| || .
keryiyihellaeyae
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 92-152 3.6e-07 24.0 In-house 67-125 (347) alignment 
Range on Protein: 92-152
Range on HMM: 67-125/347.0
DERTEYINANFISGygPRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAV
|.   ||||  |      |   || || |||.|.  ||.||   |   .|   . ....|.
ddvetyinashikf..dnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeai
subfamily_PTPN6_pd Subfamily PTPN6 93-308 6.9e-58 191.0 In-house 79-301 (306) alignment 
Range on Protein: 93-308
Range on HMM: 79-301/306.0
ERTEYINANFISGYGPRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVvYGDYVIRLQTEtNTCPQFVTSKLLI
  ..|||||.|..  .    .|||||| |..|.  ||||||. ...|||| |  || .  || ||||.   ..  ||.. ..  .| ..  ...  .|..
pgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvse.ksladYilRelsv

S--CGDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEEG----GPIVVHCSAGVGRTGCFINIDIGMQQWDELGV---VDILSNVCKTRRQR
|    ... ||. .. ...|||.|||.  . .  |... .  ..|      ||||||||||.|||| || ||| ...  . |.   .|| . | ..|.||
skkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqr

GLSVQTPVQYVYIHFVLLEYMRQNP
   |||  || ... .. .|.... 
sglvqteqqykfvykaikkyietkk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 93-302 3.6e-42 139.2 In-house 55-264 (283) alignment 
Range on Protein: 93-302
Range on HMM: 55-264/283.0
ERTEYINANFIS-GYGPRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDvGtSVVYGDYVIRLQTETnTCPQFVTSKLL
|  .|||| ||      .   .||..|.|| .|.  ||.||.. |   ||| | | |.. .|| .|||.. | |. ||.. . |. || |   |.  .||
esrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr.G.sedyGeftvtlrket.tsnsfiikell

ISCG---DDDIReITHLWWRAWPDQGVPETADGIFPFINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLSVQ
.       . .  ..|     | . |     . .  |        ... ||||||||.|.|||. || .   ...     |||. . |   | ||   ||
lrvnssakstll.lahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavq

TPVQYVYIHFVLLE
|  ||  .| . ||
tldqyklvhelvle
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 93-306 4.3e-40 132.6 In-house 65-279 (307) alignment 
Range on Protein: 93-306
Range on HMM: 65-279/307.0
ERTEYINANFISGyGpRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIR-----LQTETN-TCPQFV
  ..|| ||..         ..|..||||  |.  || |. . |   ..|  ...|   .|||.||| . |   |.|.         | ...     ...
lasdyihanylgi.a.ikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedli

TSKLLISCGDDDIREITHLWWRAWPDQGVPETADGIFPFINTARdvadEEGGPIVVHCSAGVGRTGCFINIDIGMQQW-DELGVVDILSNVCKTRRQRGL
    |     .. | |.|| |  |||.|||..  .   .... |     .  |.||||||||||.|  . | . ...  .     |.   | . | ||  
nvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr....ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhy

SVQTPVQYVYIHFVLLEYMRQ
..|| .||.|.| |||||. .
aiqteaqylylhrvlleyfle
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 94-304 7.2e-33 108.8 In-house 58-270 (285) alignment 
Range on Protein: 94-304
Range on HMM: 58-270/285.0
RTEYINANFISGYGpRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRLQT-ETNTCPQFVTSKLLI
  .|| |...   | .    ||.|||||| |.  ||.|... |   ..|   |.|    ||  |.|. .|  | .| | | |   . ..    .   | .
drdyihaswmrmpg.kdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltv

SCGDDDIRE---ITHLWWRAWPDQGVPETADGIFPFINTARDVADEEgGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLSVQT
   .|   |   . |.    ||||  || |  .  . .  . |  .|  ||.||||||||||  |. ||    .  |   ...|  | . |  |  .||.
intedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke.kpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqs

PVQYVYIHFVLLEYM
 .|..... ||.||.
hmqflflyvvlmeyf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 94-222 1.8e-23 77.8 In-house 58-186 (297) alignment 
Range on Protein: 94-222
Range on HMM: 58-186/297.0
RTEYINANFISGYGPRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRLQTETNTCPQ--FVTSKLL
 ..||||...      |  .|| .||||  |.  ||..|.|    |||| . | |.   ||  |||. |.     ||.|.   ..|    .  ..|   |
erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelql

ISCgdDDIREITHLWWRAWPDQGVPETADGI
|    .. | ..|  . .||| |||   . .
iyr..sesrvvrhvqflswpdhGvpsdledl
subfamily_eak_pd Subfamily eak 94-232 3.2e-12 40.5 In-house 77-210 (332) alignment 
Range on Protein: 94-232
Range on HMM: 77-210/332.0
RTEYINANFISgYgPRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRLQTEtNTCPQFVTSKLLIS
|  ||||  .  . .    .|| |  .    . |||.|| | |.  ||.  . ||..  | ..|.|..    . .| . .  .       .. | .| .|
rlGyinaslae.f.sevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkef.vkrniletrllels

CGDDdIREITHLWWRAWPDQGVPETADgIFPFINTARDV
 |..   .. |     | .  .|   |  . . .. ..|
kGne.thrvlhykvfGwtettlpkyed.flalrkvmkev
0051429 (Phosphotyrosine protein) phosphatases II 95-306 3e-47 156.9 In-house 4-227 (272) alignment 
Range on Protein: 95-306
Range on HMM: 4-227/272.0
TEYINANFISGYGPRA-MDRYIATQGPLPHTILAFWRMvWESKTHVIVMSTDLVENNAVKCERYWP----------QDVGTSVVYGDYVIRLQTETNTCP
. ||||....||| .   .|.....||||.|.  |||. .| . ..||. ....| ...||.||||           |. ... ||.....|. |...  
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

QFVTSKLLISC-GDDDIREITHLWWRAWPDQGVPETAdgIFPFINTARDvadeeGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVD--------ILS
  ..  ||. . . ...||..||....||| |||. |  .  ...  .|     |||..||||||..|||... ... ......  .||        .. 
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

NVCKTRRQRGLSVQTPVQYVYIHFVLLEYMRQ
 | . |.||  .|||. ||.... .|||..| 
aveelraqrpgavqteeqylflyeallellrs
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 95-307 5e-37 122.3 In-house 73-290 (305) alignment 
Range on Protein: 95-307
Range on HMM: 73-290/305.0
TEYINANFISGygPRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVY--GDYVIRLQTETNTCPQFV------
 ||| ||..|   |    |.| || || .|   || | .. | . | |  .|.|  | ||  |.. . .  . .  ..  | .. |. .  .|.      
heyihanyvst..ptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakak

--TSKLLISCGDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVAdeegGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSN-VCKTRRQR
   ..|.|     . | .||  |  |||.||| .   |. ... ||       ||||||||||.||||  . ..  ..|  .  ...     . | | ||
vtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk....gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqr

GLSVQTPVQYVYIHFVLLEYMRQN
  |.||  ||...| |.|.|.|..
nnsiqtdaqylfvhqvilnyfrkk
0051082 (Phosphotyrosine protein) phosphatases II 95-301 4.8e-33 109.2 In-house 3-150 (151) alignment 
Range on Protein: 95-301
Range on HMM: 3-150/151.0
TEYINANFISGYgpramdrYIATQGPLPhtilAFWRMVWESKTHVIVMSTDLVENNavKCERYWPQDVgtsvvygdyvirlqtetntcpqfvtskllisc
. |||.... |.       .....|||.    .|.....| .  .||. ....|..  .| .|.|.                                  
sdyinfsyvtgg.......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

gdddiREITHLWWRAWPDQGVPETADGIFPFINTARDvadEEGGPIVVHCSAGVGRTGCFINIDIGMQQwdelgvVDILSNVCKTRRQRGLSVQTPVQYV
     .|..|...  |||.|.|.. | .  |.. ..|    ..||..||||||.||||... ... ...      |.. . .   |..|. .||.. |..
.....ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqfl

YIHFVLL
...|.||
fqlfall
subfamily_egg_pd Subfamily egg 95-306 2.2e-29 97.1 In-house 68-272 (307) alignment 
Range on Protein: 95-306
Range on HMM: 68-272/307.0
TEYINANFISGyGPrAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNavKCERYWPQDVGTSVVY--GDYVI-RLQTETNTCPQFVTSKLL
 ..| || ..| .|  .. .| .| ||  |   |||||.. . . ||| |  .|..  .|| |||.    |.|.  | . |  |. . .. | |  .|| 
ddfihanrvkG.kp.llnefilaqaplkntvddfwrmvfqeevqyivmltsrkese..rceyywpkaesdslvtvpGslrienlkvdskadplfrvtklk

ISCGDDDIREITHlWWRawpdqGVPETADGIFPFiNTARDVAdEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDE--LGVVDILSNVCKTRRQRGLSVQT
.  |||. | . | |        | ...|  .|. .  | .  .   |.||..  || ...... |.| . .     .    .|  |   |..| |||..
lvGgddeerfleh.wqg.....dvnnssdvyspl.rvlrklr.nlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsves

PVQYVYIHFVLLEYMRQ
...|.... ..| ..|.
vllylfvyrlvlfffrd
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 95-305 3.5e-23 76.8 In-house 67-277 (312) alignment 
Range on Protein: 95-305
Range on HMM: 67-277/312.0
TEYINANFISGYgpRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGT-----SVVYGDYVIRLQTETNTCPQfVTSK
  || |||.        .|...|||||  |.  ||...    .  |.. . .||. . || .|  . ||        || .|.  ..   ..  . .| .
nfyihanfvkic..tkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdk.ithr

LL---ISCGdDDIREITHLWWRAWPDQGVPETADGIFPFINTARdvadEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLS
.|   . .   .   . |  | .|||.|.|.. |  . .. . .     .  |.. |||||||||| .. |.  .         ..       |..|  |
vlkvvvkat.gqesklnhyqwaswpdhgmpdscdtalrllsavk....kdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrars

VQTPVQYVYIHFVLLEYMR
|..  ||||   ..||.. 
vrvfpqyvyalrcvlefly
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 95-162 1.9e-08 28.3 In-house 122-182 (244) alignment 
Range on Protein: 95-162
Range on HMM: 122-182/244.0
TEYINANFISGYGPRAmdRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENnavkcERYWPQDV
  |||| |.   |  |   || || ||  | . ||.|. | .  |.|.   . |.     . |||.  
ntyinasfvgclgrta..eyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdse
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 95-192 1.2e-06 22.8 In-house 13-102 (130) alignment 
Range on Protein: 95-192
Range on HMM: 13-102/130.0
TEYINANFISGYGpRAmDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENnavkcERYWPQDVGTSvVYGDYVIRLQTETNTCPQFVTSKLLI
 .||||.|.   | |.   |. || ||  | . ||.|. |    |.|.   . |.     . |||.       | . .|   |. .   .  .|.| |
ntyinasfvGllg.rt.aeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePle.wyeediivtltdrdefknikasnlei
0036282 (Phosphotyrosine protein) phosphatases II 96-297 1.6e-42 140.5 In-house 3-163 (174) alignment 
Range on Protein: 96-297
Range on HMM: 3-163/174.0
EYINANFISGYGPRAmdRYIATQGPLPhtilaFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQdvgtsvvygdyvirlqtetntcpqfvtskllisCG
 ||||......      |.||.||||.     ||.|..| . ...|| ....|.. .|| .|||                                    
dyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lr

DDDIREITHLWWRAWPDQGVPETADgIFPFINTARDVADE-EGGPIVVHCSAGVGRTGCFINIDIGMQQWDeLGVVDILSNVCKTRRQRGLSVQTPVQYV
.|  |.. ....  ||| |||...  .. |.. ....  | .|||..|||||||||||... ... ....   ..||.|. | . |.||. .|||| || 
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

YIH
...
fly
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 96-296 1e-30 101.5 In-house 76-273 (301) alignment 
Range on Protein: 96-296
Range on HMM: 76-273/301.0
EYINANFISGYGprAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRLQTETNTCPQFVTSKLL---I
  | ||.|.  |    .|.|||||||. |   || |.   . . ||| .  ||..  ||| | |.... ..  | . |.....     . .. . |    
vPihanwiptsG..hphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtleved

SCGDDDIREITHLWWRAWPDQGVPETADGIFPFINTARdvadEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLSVQTPVQ
| |. . | .||  .  |.|.|||..   .| ... ..    .   |||||||||.||. .||  ..  .. .    ...   . . | .|  .|||  |
stgkfatrtvthyqysewtdrgvPkshaelfdlmelvk....ksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsq

YVYI
  ..
lywm
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 96-307 1.1e-10 35.6 In-house 70-282 (303) alignment 
Range on Protein: 96-307
Range on HMM: 70-282/303.0
EYINANFISGygpRAMDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGtSVVYGDYVIRLQTET--NTCPQFVTSKllIS
 || |...      .  . | || ||.||   ||.|. | | .....     | . .  .  .|..    . . . .||.      .    .|     .|
syihasylel...dsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd.flkfeersirvgefkrvelgdgwvlkv..ls

CGDDDIREITHL-WWRAWPDQGVPET-----ADGIFPFINTARDVADeeGGPIVVHCSAGVGRTGCFINIDI-GMQQWDELGVVDILSNVCKTRRQRGLS
  . | . . |.  ..||| . .|          |.      |  .|  . | |    .|.||.| |  ..   .   .|   .|..  . . |  |  .
vsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysd..stptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlha

VQTPVQYVYIHFVLLEYMRQN
||   |. ... .| |.. .|
vqnlsqfsvvytllaehvldn
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 111-287 3.1e-26 86.8 In-house 4-186 (199) alignment 
Range on Protein: 111-287
Range on HMM: 4-186/199.0
MDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRLQTETNTCPQFVTSKLLIS--CGDDDIREITHLWWR
  |||||| || .|.  ||.||||. .  |||  |   |. .    |||    ..  ||   .  .| |      .|. .| .        |||.|  . 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

AWPDQGVPETADgIFPFINTARDVA----DEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDE--LGVVDILsNVCKTRRQRGLSV
.| ..  |. |  .  |. ..|.|.    .|   |..|||| | | || |. .|||..  .|    |||.. .|.|  ||    .
swkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlf.evakrlrqarcgi
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 111-176 4.3e-09 30.2 In-house 235-296 (440) alignment 
Range on Protein: 111-176
Range on HMM: 235-296/440.0
MDRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLvenNAVKCERYWPQDVgTSVVYGDYVIRLQ
 . .|||| ||  |.| |||.| . .   |.|  .|   |   |  ||| .   || .| . .  .
knafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvnt.rsvtfgpftvghk
0049260 (Phosphotyrosine protein) phosphatases II 112-297 1.5e-34 114.2 In-house 9-143 (152) alignment 
Range on Protein: 112-297
Range on HMM: 9-143/152.0
DRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWpqdvgtsvvygdyvirlqtetntcpqfvtsklliscgdddireitHLWWRAWP
 ..||||||.|.|.  ||||..| . ..||| |.|.|.. .|||.|.                                             .  .  ||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpwp

DQGVPETADGIFPFINTARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMqqwdelGVVDILSNVCKTRRQRGLSVQTPVQYVYIH
| |||. .. .  ..   .  | ..|||..|||||||||||... ... .        |...  |   |..|  .|..| |. ...
DhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 112-287 3.4e-26 86.6 In-house 4-185 (198) alignment 
Range on Protein: 112-287
Range on HMM: 4-185/198.0
DRYIATQGPLPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRLQTETNTCPQFVTSKLLIS--CGDDDIREITHLWWRA
 |||||| || .|.  ||.||||. .  |||  |   |. .    |||    ..  ||   .  .| |      .|. .| .        |||.|  . .
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDQGVPETADgIFPFINTARDVA----DEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDE--LGVVDILsNVCKTRRQRGLSV
| ..  |. |  .  |. ..|.|.    .|   |..|||| | | || |. .|||..  .|    |||.. .|.|  ||    .
wkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlf.evakrlrqarcgi
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 116-309 5.4e-24 79.6 In-house 39-226 (255) alignment 
Range on Protein: 116-309
Range on HMM: 39-226/255.0
AtqgplphTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRlQTETNTCPQFVTSKLLISCG-DDDIREITHLWWRAWPDQG
        |. .|....  .||.|.|| .|. |.. .||..|.| .     .. |  .   |.. . . . | ...   |     ....|  .. |... 
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvt.ttkssadvvlrtleitstlgekkkthtvkhysykGWiekn

VPETADGIFPFINTARDVadeegGPIVVHCSAGVGRTGCFINIDIGMQ------QWDELGVVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYMRQNP
 || |  |   .  .||       ..|||||.|.||.  |. ...  |      .  | . .| || . ..| .|  ...||.|  .  ...|...  . 
aPelareilnilkvvrds.....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkg

R
 
e
subfamily_hpo-7_pd Subfamily hpo-7 121-311 7.5e-22 72.5 In-house 43-235 (263) alignment 
Range on Protein: 121-311
Range on HMM: 43-235/263.0
LPHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRlQTETNTCPQFVTSKLLISCG-DDDIREITHLWWRAWPDQGVPETA
|  || .|....  .||.|.|| .|  |.. .||..|.| .     .. .  .   |..   .   | .||   |    .....|  .. |...  || |
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvc.ttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpela

DGIFPFINTARDVadeegGPIVVHCSAGVGRTGCFINIDIGMQ------QWDELGVVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYMRQN-PRED
  |.  .. ||.       ..|||||.|.||.  |  ...  |      .  . . .| || . ..| .|  ...||.|  .  ...|... .| ....
reilnilkvarns.....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakge
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 122-299 1.1e-18 61.7 In-house 101-283 (302) alignment 
Range on Protein: 122-299
Range on HMM: 101-283/302.0
PHTILAFWRMVWESKTHVIVMSTDLVENNAVKCERYWPQDVGTSVVYGDYVIRLQTETNTCPQFVTSKLL----ISC-----GDDDIREITHLWWRAWPD
  |.  .| .. . .. ..|  ...||..  ||  |. ..||  . .| | ..     .   .|   | .    .        ..  . .  | . ||||
kstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpd

QGVPETADGIFPFINTARDVADEeggpIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLSVQTPVQYVYIHFV
 | |. |.  .  ..       .    ..||||||||||| .. |  |.|   .  | |.|| |.  |. |  .||.  | .|. ..
hGapkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllc
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 122-308 2e-13 44.4 In-house 103-289 (302) alignment 
Range on Protein: 122-308
Range on HMM: 103-289/302.0
PHTILAFWRMVWESKTHVIVMST-DLVENNavKCERYWPQDVGTSVVYGDYVIR---LQTETNTCPQFVTSKLLISCGDDDIREITHLwwRAWPDQGVPE
.. .  |||||.. |   .|.   .   ..    . ..|.  |. . ||.  .     .   ..  ..|   |   | .  . ....|    |... ||.
edsveeFWrmvfqekivsvvilvgeeelkk..tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvl..tnWkqkkvpv

TADGIfpfINTARDV---ADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYMRQNP
    .   |.|| .|     .   ..|.    |.|| | |.   . ... ..   . |   | . | ||  .|..  ||| .. .|| |.... 
kyael...iktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkv
0048076 (Phosphotyrosine protein) phosphatases II 157-303 1.9e-22 75.0 In-house 2-142 (145) alignment 
Range on Protein: 157-303
Range on HMM: 2-142/145.0
YWPQDVGTSVVYGDYVIRLQTETNTCPQFVTSKLLISCGDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADEEgGPIVVHCSAGVGRTGCFIN
|||. .  .. .|..   |. |.    .. |   | |  ..  |.......  ||| |||. .. .  |..  ... .|. ||..|||||||||||... 
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlva

IDIGMQqwdeLGvVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEY
... ..    || |.. . . . |.||  .|..| |. ... ..||.
aylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 195-298 1.4e-20 68.9 In-house 42-139 (144) alignment 
Range on Protein: 195-298
Range on HMM: 42-139/144.0
GDDDIREITHLWWRAWPDQGVPETADGIFPFINTARDVADeEGGPIVVHCSAGVGRTGCFINIDIGMqqwdELGvVDILSNVCKTRRQRGLSVQTPVQYV
 .. .||......  ||| |||. .. .  |..  ... . ||||..|||||||||||... ... .    .|| ... . .   |..|  .|..| |. 
pefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlr

YIHF
... 
fLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 200-303 7.8e-17 55.7 In-house 89-193 (440) alignment 
Range on Protein: 200-303
Range on HMM: 89-193/440.0
REITHLWWRAWPDQGVPETADGIFPFINTARDVADEEG-GPIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLSVQTPVQYVYIHF
| . .  ...|||.|||. |  .. .|.   .  .. | ||..||||||.||||  | .|  ...      .||.| .   | .|   |||| ||...| 
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhe

VLLEY
..|| 
avleg
PTPc_DSPc_SM00012 202-302 2.4e-27 90.6 In-house 2-105 (105) alignment 
Range on Protein: 202-302
Range on HMM: 2-105/105.0
ITHLWWRAWPDQGVPETADGIFPFINTARDVADEE--GGPIVVHCSAGVGRTGCFINIDIGMQQWDEL-GVVDILSNVCKTRRQRGLSVQTPVQYVYIHF
..|... .|||.||||..| |. ...  ...  ..  ..|.||||||||||||.|. .|| .|| ..  . |||.  |.. |.||  .|||  ||.... 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VLLE
.|||
alle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 203-295 5.5e-10 33.5 In-house 218-335 (350) alignment 
Range on Protein: 203-295
Range on HMM: 218-335/350.0
THLWWRAWPDQGVPETADGIFPFIN---------TAR-DVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDELGVV--------------DILS-NVC
 .| .. |.| ..      | . ..         .|.  . .... ||.||||||||||| .. .|  ... . |  .              |..|  | 
yqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivn

KTRRQRGLSVQTPVQYVY
. |.||   ||.  |...
elrkqrismvqnldqfif
0048567 (Phosphotyrosine protein) phosphatases II 206-255 7.6e-06 20.4 In-house 41-95 (157) alignment 
Range on Protein: 206-255
Range on HMM: 41-95/157.0
WWRAWPDQGvPETADGIFPFINTARDVA---DEEGGPIVVHCSAGV---GRTGCFI
..  . | | | . . .. ||. . ..    ...|..|.|||.||    |||...|
yedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLi
PTEN_1 207-255 1.6e-07 26.3 In-house 99-148 (196) alignment 
Range on Protein: 207-255
Range on HMM: 99-148/196.0
WRAWPDQGVPETaDGIFPFINTARDVAD--EEGGPIVVHCSAGVGRTGCFI
 . ..| |.|   . .| ... . . .   ..|. ..||| ||.||.|. .
hfpieDhgapsl.selfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv
0038934 (Phosphotyrosine protein) phosphatases II 208-255 3.2e-09 32.2 In-house 85-133 (194) alignment 
Range on Protein: 208-255
Range on HMM: 85-133/194.0
RAWPDQGVPETADGIFPFINTARDVADE-EGGPIVVHCSAGVGRTGCFI
  .||.|.. . . .. |.. . .. .| .|| ..||| ||.||||...
lpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlv
PTPc_motif_SM00404 214-255 3.3e-06 22.0 In-house 61-98 (140) alignment 
Range on Protein: 214-255
Range on HMM: 61-98/140.0
GVPETADGIFPFINTArdvaDEEGGPIVVHCSAGVGRTGCFI
 . .  | .  ||..|     ..|| ..||| ||| |....|
klskyldkvldfiena....ekkggkvlVHCqaGvSRSatli
DSPc Dual specificity phosphatase, catalytic domain 225-255 3.5e-06 21.9 Pfam-A 65-91 (133) alignment 
Range on Protein: 225-255
Range on HMM: 65-91/133.0
FINTArdvaDEEGGPIVVHCSAGVGRTGCFI
||..|    ...|. ..||| ||. |....|
fieka....eqkgkkvlVHCqaGisRSatli
DSPc Dual specificity phosphatase, catalytic domain 225-255 3.5e-06 21.9 In-house 65-91 (133) alignment 
Range on Protein: 225-255
Range on HMM: 65-91/133.0
FINTArdvaDEEGGPIVVHCSAGVGRTGCFI
||..|    ...|. ..||| ||. |....|
fieka....eqkgkkvlVHCqaGisRSatli
subfamily_CG42327_pd Subfamily CG42327 229-304 1e-16 55.6 In-house 239-315 (319) alignment 
Range on Protein: 229-304
Range on HMM: 239-315/319.0
ARDVADEEGGPIVVHCSAGVGRTGCFINIDIGMQQWDEL-GVVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYM
.|    |. ||.||||| ||||||  |  || ... .|    |||   |   ||.|. .|.|  || .|. || || 
srsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_CDC14_pd Subfamily CDC14 231-257 2.2e-06 21.7 In-house 257-283 (328) alignment 
Range on Protein: 231-257
Range on HMM: 257-283/328.0
DVADEEGGPIVVHCSAGVGRTGCFINI
..|..  | |.||| ||.||||..|  
eiaekaeGaiavhCkaGLGrtGtLiac
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 234-261 1.6e-06 21.7 In-house 262-289 (349) alignment 
Range on Protein: 234-261
Range on HMM: 262-289/349.0
DEEGGPIVVHCSAGVGRTGCFINIDIGM
...  ...|||||| |||| .. .|. .
tdqlstllvhcsaGcGrtGvlvtldlll
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 239-302 2.2e-08 28.3 In-house 230-293 (297) alignment 
Range on Protein: 239-302
Range on HMM: 230-293/297.0
PIVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLE
...|||||||||.|  .  |. ...     . |. . . . | ||   |||  |. ... . |.
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_PTEN_pd Subfamily PTEN 239-299 4.9e-06 21.7 In-house 116-175 (184) alignment 
Range on Protein: 239-299
Range on HMM: 116-175/184.0
PIVVHCSAGVGRTGCFINIDIgMQQWDELGVVDILSNVCKTRRQRGLSVQTPVQYVYIHFV
 .|||| || ||||  |   . ...       ..|.   ..| . . .|. | |  |....
vvvvHCkaGkGRtGvlivayl.lkslllekaeealelfaeaRtknkkgvtiPsqrRYveYy
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 240-304 1.8e-13 44.7 In-house 1-65 (69) alignment 
Range on Protein: 240-304
Range on HMM: 1-65/69.0
IVVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYM
.|||||.| |||| || | . | .     .|||. ||   |. | . |   ..|..||  | | .
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 241-304 2.6e-12 40.9 In-house 1-64 (69) alignment 
Range on Protein: 241-304
Range on HMM: 1-64/69.0
VVHCSAGVGRTGCFINIDIGMQQWDELGVVDILSNVCKTRRQRGLSVQTPVQYVYIHFVLLEYM
|||||.| |||| || | . | .     .|||. ||   |. | . |    .|..||  | | .
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal