Gene MbrePTP-Un-3 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP057_AA protein Get Run
MbreP057_AA_261-495 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 220-500 1.1e-30 101.8 In-house 8-290 (297) alignment
Range on Protein: 220-500
Range on HMM: 8-290/297.0
RPLSTAQLASVV-HNMTITSLQDDFRTLPLHLASSKSLGEHL--LRELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGnpmRFIVTQAPLSgf
||.  ...|..| .|.  .  ...|. ||     ..   |.   .   |   |||. . |..|        | ..||  |.|..    |.| || |    
rpiplsdfatlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmk..

esgrvGTQVAFWSMVYQYQAPVVIMLIEPQ--PHRCTRYWPvPDGNLRSGPFEVRHHGFDKHRGFLVSSLSLTLRG-K-THRFQHICLSGWNEHGLPR--
      |   || ||...|. ...|| . .   ..|.|||.  .|    |   |  .  .. .||.  .|..|    | ..  .      | ..  .|  
.....atvadfWamvldeqvstivmlnddnerdkkcaryWs.dkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkd

SSKSVIALLRYLRN---LKVRGPIVVHDDRGLGPSGVFVASDYCIDQAQA-GKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGKDQK
| .|.. |.  .|.    .  ||..||   |.|  ||... | .. .|.   .||... |  |||.|  ||  . .|.... .|| .|  .|..
sassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtr

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 221-495 2.4e-27 90.6 In-house 2-278 (315) alignment
Range on Protein: 221-495
Range on HMM: 2-278/315.0
PLSTAQLASVVHNMTI-TSLQDDFRTLPLHLASSKSLGEHL--LRELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNpMRFIVTQAPLSgfe
|.  ||. ..| .    . . ..|. ||   .. .  . .    .  |   |||  ..|..|.       | .|||  ..... .   .| .|.||    
pipvaqfpafvnknrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvddd.kayiasqgPlk...

sgrvGTQVAFWSMVYQYQAPVVIMLIEPQP-H--RCTRYWPVPDGN-LRSGPFEVRHHGFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSK
     .   ||.||.|...  ..|. . |     .| .|||  ...  . | ..|     .   .  .  | .    ....     . .| ..| .. . 
....asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqts

SVIALLRYLR--NLKVRGPIVVHDDRGLGPSGVFVASDYCIDQAQAG-KVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLD
|.. |.. ..  | |   ...||   | | .||... | ...|.. .  |||.. | .||..|  || .. || .|.  || .| 
sllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 222-495 2e-27 90.5 In-house 2-277 (515) alignment
Range on Protein: 222-495
Range on HMM: 2-277/515.0
LSTAQLASV-VHNMTITSLQDDFRTLPLHLASSKSLG--EHLLRELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQgNPMRFIVTQAPLSGfes
|  ||. .   .|   | . ..|. ||      ...   |   .  |   |||  ..|..|.    .  | ..||  ...|. |   .| .|.|.     
lplaqfPafvnknrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfd.ndkayiasqgPnka...

grvgTQVAFWSMVYQYQAPVVIMLIEP---QPHRCTRYWPV-PDGNLRSGPFEVRHHGFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSKS
    .   ||..|.|..   ..|. .       .|..|||  |   .. | ..|     .   | .   | ..   ...      . .| ..| |. ..|
....svddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtss

VIALLRYLRN--LKVRGPIVVHDDRGLGPSGVFVASDYCIDQAQAG-KVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLD
.. |.. ..    ..  |...|   | |  ||... | .. .|. .  |||.. |  .||.|  ||  . .| .|.  || .| 
llklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 225-497 1.9e-38 127.4 In-house 15-293 (298) alignment
Range on Protein: 225-497
Range on HMM: 15-293/298.0
AQLASVVHNMTITSLQDDFRTLPLHLA----SSKSLGEHL--LRELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNPmRFIVTQAPLSgfes
 .||.| .....| ....|..|          .|. ...    .  | . |...  .|. | .  . ..| .|||  . ...|..  ||.|||||     
qklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPlt....

grvGTQVAFWSMVYQYQAPVVIMLIEPQP---HRCTRYWPVpDGNLRSGPFEVRHHGFDKHRGFLVSSLSLTLRG--KTHRFQHICLSGWNEHGLPRSSK
    | . || || .... ...|| . .     ....|||  .|. . | ..|. .  ...  . |  | .. .   |... ...  . | ..| |. ..
...etvedFWrmvteedigtiVmltnleeldktkyhkywPd.egketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenat

SVIALLRYLRNLKV-RG--PIVVHDDRGLGPSGVFVASDYCIDQAQAGK-VDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGK
||..|||  |  .   |  |..|.   | | || |.| |  ...... . |||.|.| .||..|...|.....| .|. .|| .||  
svldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf

subfamily_ptpA1_pd Subfamily ptpA1 235-447 1.2e-11 39.0 In-house 19-248 (418) alignment
Range on Protein: 235-447
Range on HMM: 19-248/418.0
TITSLQDDFRTLPLHLASSK-SLG--EHLLRELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGfqGNPMRFIVTQAPLSgfesgrvGTQVAFWSMV
 |  ....|| |   .  |. | |  .|   . |   |||   ||.|| .    . | .|||| . |    | .||.|| ||         |   || ||
cihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg..aypkqfictqgplp.......ntiadfwrmv

YQYQAPVVIMLIE---PQPHRCTRYWPVP----------DGNLRSGPFEVRH--HGFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSKSVI
.. .. ...||         .| ||||            .||   | . |       |  |  .   . ||. |.|.   .    || .| .|  .. . 
wenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfr

ALLRYLRNLKV--------RGPIVVHDDRGLGPSGVFVA
 ||. . | .           ||.||   |.| .| |..
qllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfct

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 236-494 2.2e-39 130.2 In-house 4-268 (274) alignment
Range on Protein: 236-494
Range on HMM: 4-268/274.0
ITSLQDDFRTLPLHLASSKSLGEHLLRELREPRILPSVTTRIQLDRPP-GAKISGFINANAVRGFQGNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQY
 ..|...|  |||     .       .  |   |||  ..|. | .    .. | .|||| ..|....   .. || ||.        |   || |.|| 
fkdlekeflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlp.......ntvadfWrmiyqe

QAPVVIMLI---EPQPHRCTRYWPVPDGN---LRSGPFEVRHHGFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK--
...|..||    | . ..|..|.|   .     | | .|.. ..  .. .. | .|.|    .... .|.  . | .|  |.. .... |..  .. .  
evqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesree

--V-RGPIVVHDDRGLGPSGVFVASDYCIDQA-QAGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
    ..|.|||   |.|  |.|.| . .. |  . ..|||.. |  ||.||  .|...  |..||| .  ||
enaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 239-494 1.4e-36 121.1 In-house 23-279 (288) alignment
Range on Protein: 239-494
Range on HMM: 23-279/288.0
LQDDFRTL-PLHLASSKSLGEHLLR--ELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNpMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQ
.......| .|.  .|.. |..       | . |||   .|..|.  .  . . .|||. . | ...  ..| ||.||         |   || .||...
fseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkk.kkyiatqgPla.......dtvndfWelvyenk

APVVIML---IEPQPHRCTRYWPVPDGNLRSGPFEVRHHGFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKV--RGP
.  ..||   .| . ..| .|||  | . . | ..|   .  .   |.. .| |  ...  . ..    .| .|| |.|.. ...||| . . .    ||
tstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgp

IVVHDDRGLGPSGVFVASDYCIDQAQA-GKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
|.||   |.| .|.|.| |  ||. ..  ..||. .|  ||. || ||.    |..|.. .|   
iivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli

subfamily_Ptp69D_pd Subfamily Ptp69D 239-495 1.5e-32 108.0 In-house 24-287 (307) alignment
Range on Protein: 239-495
Range on HMM: 24-287/307.0
LQDDFRTLP---LHLASSKSLGEHLLRELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQgNPMRFIVTQAPLsgfEsgrvGTQVAFWSMVYQYQ
|. ....|.    .. .. |  .  .   | . | .   ||..| . .| . | .|||. ..|.. .  .||. |.|.   |    .|   || |. . .
lakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgyk.ekkkfiaaqdPv...e....atigDfWRmiaeqe

APVVIMLIE--PQPH-RCTRYWPVPdGNLRSGPFEVRHHGFDKHRGFLVSSLSLTLRG-------KTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNL
  ...|| .   ... .| .|||.   . . |   |.   ..||  .   .|...  .       ....       ||..   |....... |.. .|.|
vtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrel

K--VRGPIVVHDDRGLGPSGVFVASDYCIDQAQAG-KVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLD
.   |.|||||   | | ||.||| |  ..| .|  |||... |  ||..|  ||.| . |....| .| | .
yklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

subfamily_PTPRA_pd Subfamily PTPRA 240-496 7.1e-28 92.4 In-house 35-298 (330) alignment
Range on Protein: 240-496
Range on HMM: 35-298/330.0
QDDFRTLPL-HLASSKSL--GEHLLRELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNpMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQA
...| .||  .. ..  |   |   .  | ..|||   .|. |    | . | .|||  . |..    .|| .| |..        |   || |......
reefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykek.dkfiaaqGPke.......etvedfwrmiweqks

PVVIMLIE---PQPHRCTRYWPVpDGNLRSGPFEVRHHGFDKH-----RGFLVSSLSLTLRGKTHR-FQHICLSGWNEHGLPRSSKSVIALLRYLRNLK-
  ..|| |    . ..|..|||  .| .  |   |  .          | |||  |. . | |..|  . . . .| . |.|  .. .. ||. ...|. 
ativmltelkerkeekcaqywPd.eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnq

-VRGPIVVHDDRGLGPSGVFVASDYCIDQAQA-GKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGY-LDG
   ||||||   | | .| |.. |  ... .| .|||| ..|  ||. |. .| .   |..|.. .| | | |
qsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylyg

subfamily_CG42327_pd Subfamily CG42327 240-424 6.3e-13 43.1 In-house 8-192 (319) alignment
Range on Protein: 240-424
Range on HMM: 8-192/319.0
QDDFRTLPLHLASSKSLGEHLLRELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVV
 ..|| ||  .|..  .        |  ...|   ||. |.| .  . . ...|. |||..  |  .| .|..|         .  .|| .|.. |. |.
aeefrdlPqliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsled.......sssdfwrtvweqqsrvi

IMLIEPQP---HRCTRYWPVPD---GNLRSGPFEVRHHGFDKHRGFLVSSLSLTLR-G-KTHRFQHICLsGWNEHGLPRSSKSVIALLRYLRN
. | ...    ..|..|.|  .   ..   | . |   | . .  ...|.| |    . ..    |     | | ..| . ...||.|   |.
vqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs

subfamily_egg_pd Subfamily egg 254-494 2.8e-24 80.3 In-house 34-270 (307) alignment
Range on Protein: 254-494
Range on HMM: 34-270/307.0
KSLGEHLLRELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGfqgNP--MRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIE-PQPHRC
... .  |   |..|.    ..|..|. . |  .  || || |.|   .|    ||..||||         |.  || ||.| . . ..||    ...||
taasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkG...kpllnefilaqaplk.......ntvddfwrmvfqeevqyivmltsrkeserc

TRYWPV-PDGNLRS--GPFEVRHHGFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPrSSKSVIALLRYLRNLKvrGPIVVHDDRGLGPSGVFVA
  |||  .. .|.   | ...   . |..   |     | | |  .  ...    .. . .     | . .|| ||||    |.||.|  |   ....||
eyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnss.dvysplrvlrklrnls..kpvvvqdilGvskaatlva

SDYCIDQAQAG---KVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
 .  . .   |   |  |..||  ||. |   |||   | ...|||| ..
ieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff

subfamily_PTPRN_pd Subfamily PTPRN 258-489 1.4e-20 68.2 In-house 54-287 (297) alignment
Range on Protein: 258-489
Range on HMM: 54-287/297.0
EHLLRELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIEPQP---HRCTRYW
|. ... |.  .||   .|..|..   |. | .||| |.   .     .| ||.||.        |  .|| ||..  . |...| . .    ..|.|||
eknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgpla.......stvadfwqmvweqGvvvivnltrleeegvkqckryw

PVpDGNLRSGPFEVRHHGFD-KHRGFLVSSLSLT-LRGK-THRFQHICLSGWNEHGLPRSSKSVIALLRYLrNLKVRG---PIVVHDDRGLGPSGVFVAS
|  .|.   . .||.          .|| |. |  |. . |          |.|.| | |.||.. . | . |   ||   |||||   | | .||... 
pd.eGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkv.nksyrGrscpivvhcsdGaGrtGvyili

DYCIDQAQAG--KVDVMQAVYTLRQDRAALVESRAEYQYIHRL
|  ... . |  ..|.. ..  ||..|. ||.........   
dlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 260-413 3.5e-12 40.8 In-house 33-184 (297) alignment
Range on Protein: 260-413
Range on HMM: 33-184/297.0
LLRELREPRILPSVTTRIQLDRPPGAkiSGFINANAVRGF-QGNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIEPQ---PHRCTRYWP
 ||. |   ||   .||..| | .    . .|||. |    . .....|..| |||        |   || .|.. .  |..|. . |    ..|. |||
slrknryrdilatddtrvkllrvite..rdyinadyvvfpdeeadlkyilaqGplsa.......tvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

VPDG-NLRSGPFEVRHH--GFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSK
  .. .|..| . | .     |..    .. | |  | ..   .|.   .| .||.|   .
svvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdle

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 262-502 3.3e-25 83.5 In-house 35-274 (283) alignment
Range on Protein: 262-502
Range on HMM: 35-274/283.0
RELREPRILPSVTTRIQLDRPPGakisGFINANAVR--GFQGNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPV
|  |.  |.|    |..|.  .      .|||  .     . .  ..|..|.||         |.| || ||.. ..  ..||    | .  .|..||| 
rknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPld.......rtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk

pDGNLRSGPFEVRHHGFDKHRGFLVSSLSLTLR---GKTHRFQHICLSGWNEHGLPRSSKSV--IALLRYLRNLKVRGPIVVHDDRGLGPSGVFVASDYC
 .|    |.| |  .    .. | .  | |       .|    |  . .| | |      |.  . ... |.. . .||||||   | | ..||.|    
.rGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasas

IDQAQAGK-VDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGKDQKGA
...|..   |||.. |  .|..|  .| ..  |. .| |||      | . |
vkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqia

0049772 (Phosphotyrosine protein) phosphatases II 262-495 7.9e-19 64.0 In-house 48-281 (314) alignment
Range on Protein: 262-495
Range on HMM: 48-281/314.0
RELREPRILPSVtTRIQLDRPPGAKiSGFINANAVRGFqgnpMRFIVTQAPLSgfesgrvGTQVAF----------WSMV--YQYQAPVVIM--------
  .| ..|||   .| .|.. |.   |..|||. |.||    ..||.||.||.        | | |          |.||  ....  .. |        
dknryldilpad.nrvilpglpvsg.sdyinasyvdgf....lkfIatqgple.......itvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------LIEPQPHRctrywpvpdgnlR----------SgpfevrhhgfD-------KhrgflvsslsltlrgKTHRFQHICLsGWNEHGLPrS
             |... ..                                   .                       . . ......  .  .. | .
elsrLdaAlgKtpllildgng............neptaadlellk..........eelydpelf...............erlgikylri.pvpDgsap.l

SKSVIALLRYLRNLKVRGPIVVHDDRGLGPSGVFVASDYCIDQAqagKVDVMQAVYTLRQDRA-----ALVESRAEYQYIHRLVLGYLD
.. . ..|.......  ||..||   | | .|.||. .|.. .    .|.. .|.  .|. |       ..|.  .|..|.. .| ||.
ledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll...gvsleealedvrlkRpinpnpgfieqleqyefilealleylk

DSPc_SM00195 263-494 4.6e-48 159.2 In-house 29-262 (263) alignment
Range on Protein: 263-494
Range on HMM: 29-262/263.0
ELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFqGNPMRFIVTQAPLsgfesgrVGTQVAFWSMVYQYQAPVVIMLIEPQP---HRCTRYWPVP-D
  |   |||   ||..|..... . | .|||| ..|   .. ..|.||.||         |   || ||.. . ....|| |..     .|.||||   .
knRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPl.......pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesg

GNLRSGPFEVRHHGFDKHR-GFLVSSLSLTLRG--KTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKV--RGPIVVHDDRGLGPSGVFVASDYCID
|. . | ..|     .|..  . .  |.||  |  .|......   .|..||.| | |||..|||.... |    |||||| . |.| .|.||. |....
gketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiils

QAQAG-KVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
. ... |||. . |  ||. |. .|.....|..|.. .| |.
kleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 263-494 4.6e-48 159.2 In-house 29-262 (263) alignment
Range on Protein: 263-494
Range on HMM: 29-262/263.0
ELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFqGNPMRFIVTQAPLsgfesgrVGTQVAFWSMVYQYQAPVVIMLIEPQP---HRCTRYWPVP-D
  |   |||   ||..|..... . | .|||| ..|   .. ..|.||.||         |   || ||.. . ....|| |..     .|.||||   .
knRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPl.......pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesg

GNLRSGPFEVRHHGFDKHR-GFLVSSLSLTLRG--KTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKV--RGPIVVHDDRGLGPSGVFVASDYCID
|. . | ..|     .|..  . .  |.||  |  .|......   .|..||.| | |||..|||.... |    |||||| . |.| .|.||. |....
gketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiils

QAQAG-KVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
. ... |||. . |  ||. |. .|.....|..|.. .| |.
kleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 263-500 5.6e-32 106.0 In-house 49-286 (318) alignment
Range on Protein: 263-500
Range on HMM: 49-286/318.0
ELREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNpMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLI---EPQPHRCTRYWPVpDG
  |   ||.  .||..|.   | . | .|||| . |.. .   .| .||||.        |   || ||.. .. |..||    |   ... ||||  .|
knryanilaydhtrvkLqmlegeegsDyinanyidGyrrk.kayiaaqaPlp.......etieDfWrmvWeqnsavivmltqeeergkakvhryWPs.kg

NLRSGPFEVRHHGFDKHRGFLVSSLSLTLRGKTH--RFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK---VRGPIVVHDDRGLGPSGVFVASDYCIDQ
    |   |  .   .   ... ....| ... .    .      | ..|.| |. |...|.|  .. .    .||||||   | |  |||.| |  ...
srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdiller

AQA-GKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGKDQK
..| . |||.| | .||. | ..|  .  |..|.  .| .|   |..
ikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdte

subfamily_PTPRG_pd Subfamily PTPRG 263-500 2.5e-29 96.9 In-house 50-293 (563) alignment
Range on Protein: 263-500
Range on HMM: 50-293/563.0
ELREPRILPSVTTRIQLDRPPGAKIS-GFINANAVRGFQgNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIE---PQPHRCTRYWPVpD
  |.  |...  .|..|   || | .  .|||| . |.|     ||.|| ||         |   || |... .. ...|. .    . . | .|||  |
KnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgplk.......dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.d

GNLRSGPFEVRHHGFDKHRGFLVSSLSLTL-----RGK---THRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKVR--GPIVVHDDRGLGPSGVFVAS
. .. | ..|.    ...    | .|..         .    .. ..   . | .|| | .|  |.   .     . .  ||||||.. | | .|.... 
esetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivl

DYCIDQAQ-AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGKDQK
|  . | |   .|.| . . ..|  |  ||... .|...|  .|  . .|...
dtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaskete

subfamily_PTPN23_pd Subfamily PTPN23 263-493 4.1e-26 86.4 In-house 46-279 (288) alignment
Range on Protein: 263-493
Range on HMM: 46-279/288.0
ELREPRILPSVTTRIQLDrppgAKISGFINANAVRGFQGNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIEPQP---HRCTRYWPVPDG
  |   |||   .|..|.     .   .|||  |..       ||.|||||        .|   ||.|||. ...|..||....    ... ||||   |
knrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlq.......stlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkg

NLR-SGPFEVRHHGFDKHRGFLVSSLSLTLRGKT--HRFQHICLSGWNEHGLPRSSKSVIALLRYLRN------LKVRGPIVVHDDRGLGPSGVFVASDY
.    |...|  .   .   .    |.|. ...   .  .|. |  | |.|.| | ......|   ..       |.. |.|||   | | .|||     
etvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvya

CIDQ--AQAGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGY
 . .  .. | .|..| | .||..|   |. .....     || .
avrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

0051299 (Phosphotyrosine protein) phosphatases II 264-494 1.2e-49 164.7 In-house 53-286 (288) alignment
Range on Protein: 264-494
Range on HMM: 53-286/288.0
LREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNPMrFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIEPQPHR---CTRYWPVpDGN
 | . |||   .|..|  ..|   |..|||. ..|.. .   ||.||.||.       .|   || ||.... .|..|| ... .    | .|||  .| 
nRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlp.......ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggs

LRSGPFEVRHHGFDKHRGFLVSSLSLT------LRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNL--KVRGPIVVHDDRGLGPSGVFVASDYCI
|  |.. |.    ... .. |  | .|        |.... .|..  .| .|| | | ......||..|.   .  ||.|||   |.| .|.|.| |...
ltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdlll

DQA-QAGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
.|  . |.|||..|| .||. |  .|..   |.......| ||
eqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 264-497 5.3e-35 116.0 In-house 50-286 (305) alignment
Range on Protein: 264-497
Range on HMM: 50-286/305.0
LREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNpMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLI---EPQPHRCTRYWPVPDGN
 |   | .  . ||.|   .  . | .|||. | |....  ..||.|.||         | . || ......  ...||    | . ..| .|||   ..
nrlkeitlldddriiltekeslddsdyinasyvdgykrk.kkyivaqgPlkn.......tvadfWrliveekvstivmltklveggkdkCrqYWpeskte

-LRSGPFEVRHHGFDKHRGFLVSSLSLTL---RGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKVRG---PIVVHDDRGLGPSGVFVASDYCID
  . |.|.|  . . .  ...   |...      ...   .  |  | .|| |... |.. |.. ... . ..   |..||   |.| .|||.| |  ..
kkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdiale

QAQ-AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGK
...  . |||.. . .||. |  .|.. ..|...|  .  ..   
rlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg

0037934 (Phosphotyrosine protein) phosphatases II 264-491 6.8e-35 116.2 In-house 14-239 (243) alignment
Range on Protein: 264-491
Range on HMM: 14-239/243.0
LREPRILPSVTTRIQLdrpPGakiSGFINANAVRGFQgnpmRFIVTQAPLSGFESGrvgTQVAFWSMVYQYQAPVVIMLIEPQ---PHRCTRYWPvpdGN
 | . |||   .|. |   .|   |..|||| ....     |.|.||.||..       .  .|| |.....  |..|| |..      | .|||   |.
nrysdilpydhsrvkl...eg...sdyinanliyvtp....rliatqgPlpetved...dlasfwrmlwelgitvivmltelvElgrekcaqywp...ge

LRSGPFEVRHHGFDKHRGFLVSSLSLTL---RGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLR----------NLKVRGPIVVHDDRGLGPSGVFVA
 . |.|.|.  ..  . .. |  |.|.     . |.  .|..  .| .|| | | ......|...|          .|.  ||..||   |.| .|...|
vtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtlia

SDYCIDQAqagKVDVMQAVYTLRQDRAA-LVESRAEYQYIHRLVL
 ......    .||. .|| .||. |    |...  |.......|
aylmllll...gvdleeavkllreqRpgkavqtpsqyrflyeall

subfamily_CG7180_pd Subfamily CG7180 264-493 4.3e-30 99.4 In-house 46-289 (296) alignment
Range on Protein: 264-493
Range on HMM: 46-289/296.0
LREPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQgNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIEP--QPHRCTRYWPVPDgNL
 |.. ..|   .|. |..  | . | .|||  | .|   .  .|||.||          |  .||..||. ..  |..| ..  . . .  |||    . 
nrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkke.......tvdefWrlvydeeisavvvLtktfdfakmypsywpnks.ke

RSGPFEVRHHGFDKHRGFLVSSLSLTLR------------GKTHRFQHICLSGWNE-HGLPRSSKSVIALLRYLRNLK-------VRGPIVVHDDRGLGP
. |...|     ..   .    . || .             .|   ... |  |.  . .| |....| |.|  | ..       ..||.||.   | . 
qygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasR

SGVFVASDYCIDQA-QAGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGY
|||..| | ..... . ..||| .|| |||..|  |||.  ||.||  ..| .
sGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea

0046845 (Phosphotyrosine protein) phosphatases II 265-495 2e-50 167.2 In-house 33-275 (284) alignment
Range on Protein: 265-495
Range on HMM: 33-275/284.0
REPRILPSVTTRIQLDRPPGA-KISGFINANAVRGFQ----GNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIEPQPH---RCTRYWPV
| . |||   .|. |....|  . |..|||. |.|..     ....||.||.||..       |   || ||......|..|| |.       | .||| 
RykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn.......tvedFwrmvweqnvrvIVmltelvengrekcaqYwpl

PDGNLRSGPFEVRHHGFDKHRGFLVSSLSLTL---RGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNL----KVRGPIVVHDDRGLGPSGVFVASD
 .. |. |.| |.    ... .. |  |.||     |.... .|..  .| .|| | |.......||..|.|    .  ||||||.  |.| .|.|.| |
egevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfiald

YCIDQAQAG----KVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLD
....| ...    .||| .||. ||. |   |.. . |.......| || 
llleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk

0050432 (Phosphotyrosine protein) phosphatases II 265-496 5e-49 162.7 In-house 73-301 (308) alignment
Range on Protein: 265-496
Range on HMM: 73-301/308.0
REPRILPSVTTRIQLdrppGaKISGFINANAVRGFQ-GNPMRFIVTQAPLsgfesgrVGTQVAFWSMVYQYQAPVVIMLIEPQP---HRCTRYWPVP--D
| . |||   .|. |    . . |..|||. |.|.. ..|..||.||.||        .|   || ||.... .|..|| ...      | .|||    .
rykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPl.......pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgg

GNLRSGPFEVRHHGFDKHRGFLVSSLSLTL--RGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKVRGPIVVHDDRGLGPSGVFVASDYCIDQA-
| |. |.| |..   ... .. |  | ||    |.... .|..  .| .|| | | ......|...|.    ||||||   |.| .|.|.| |....|  
gsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqle

QAGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDG
. |.||| .||..||. |.  |..   |....|..| ||  
keggvdvfeavkklReqRpgmvqtpeqylflyralleylkl

Y_phosphatase Protein-tyrosine phosphatase 265-491 7.5e-46 151.8 Pfam-A 6-234 (235) alignment
Range on Protein: 265-491
Range on HMM: 6-234/235.0
REPRILPSVTTRIQLDRPPGAKIsgFINANAVRGFQgNPMRFIVTQAPLsgfesgrVGTQVAFWSMVYQYQAPVVIMLIEPQP---HRCTRYWP-VPDGN
| . |||   ||..|.  .|..   .|||| |.|.. .. .||.||.||         |   || ||.|..  |..|| . .      | .|||   .. 
Rykdilpydktrvklkgsegpsd..YInAnyvkgyk.ekkkfIatQgPl.......kstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

LRSGPFEVRHH-GFD-KHRGFLVSSLSLTLRGKTH---RFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK--VRGPIVVHDDRGLGPSGVFVASDYCID
|. | ..|.       .. .. .. |.|. ... .   ..... . .|..||.|.|.||.. |.| ... |   .||.|||   | | .|.||| |....
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

QAQA-GKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVL
|..| ..|||.|.| .||. |. .|.| ..|.......|
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 265-491 7.5e-46 151.8 In-house 6-234 (235) alignment
Range on Protein: 265-491
Range on HMM: 6-234/235.0
REPRILPSVTTRIQLDRPPGAKIsgFINANAVRGFQgNPMRFIVTQAPLsgfesgrVGTQVAFWSMVYQYQAPVVIMLIEPQP---HRCTRYWP-VPDGN
| . |||   ||..|.  .|..   .|||| |.|.. .. .||.||.||         |   || ||.|..  |..|| . .      | .|||   .. 
Rykdilpydktrvklkgsegpsd..YInAnyvkgyk.ekkkfIatQgPl.......kstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

LRSGPFEVRHH-GFD-KHRGFLVSSLSLTLRGKTH---RFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK--VRGPIVVHDDRGLGPSGVFVASDYCID
|. | ..|.       .. .. .. |.|. ... .   ..... . .|..||.|.|.||.. |.| ... |   .||.|||   | | .|.||| |....
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

QAQA-GKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVL
|..| ..|||.|.| .||. |. .|.| ..|.......|
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

0039614 (Phosphotyrosine protein) phosphatases II 265-497 5.1e-45 149.6 In-house 61-292 (297) alignment
Range on Protein: 265-497
Range on HMM: 61-292/297.0
REPRILPSVTTRIQLDRPPGA-KISGFINANAVRGFQGNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIEPQPHR--CTRYWPVPDGnl
| . |||   .|..|  ..|    | .|||. | |.  ....||.||.||..       |   || ||.... .|..|| .. ..   | .|||   |  
rykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe.......tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg..

RSGPFEVRHHGFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK----VRGPIVVHDDRGLGPSGVFVASDYCIDQAQ-
. |.| |.  ..... |. |  |..|  |...  .|..  || .|| | |..... .|...|.        ||..||   |.| .|.|.| .....| . 
tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlek

AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGK
 |.||| .|| .||. |   |..   |.......| .|  |
eggvdvleavkelreqRpgavqtpsqyrflydallellkrk

0036941 (Phosphotyrosine protein) phosphatases II 265-498 7.3e-44 145.6 In-house 44-281 (297) alignment
Range on Protein: 265-498
Range on HMM: 44-281/297.0
REPRILPSVTTRIQLdrppGAKISGFINANAVRGFqGNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIEPQPH---RCTRYWPVP-DGN
| . |||   ||..|    .   |..|||. | |. . ...||.||.||.       .|   || ||.... .|..|| |. .     | .|||   .. 
RykdilpydhtRVkl....ddegsdYinAsyvdgy.dlkrkfIatqgPlp.......ntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleeges

LRSGPFEVRHHGFDK--HRGFLVSSLSLTL--RGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK----VRGPIVVHDDRGLGPSGVFVASDYCI
|  |.| |.  ....  . .. .  | .|    |.... .|..  || .||.| | .|........|.        ||..||   |.| ||.|.| |...
ltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlml

DQAQ----AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGKD
.| .     |.||. .|| .||. |.  |..   |.......| .|  |.
qqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl

0047943 (Phosphotyrosine protein) phosphatases II 265-494 8.9e-44 145.4 In-house 43-272 (273) alignment
Range on Protein: 265-494
Range on HMM: 43-272/273.0
REPRILPSVTTRIQLdrppGAKISGFINANAVRGFQGNPMrFIVTQAPLsgfesgrVGTQVAFWSMVYQYQAPVVIMLIEPQPH---RCTRYWPVPDG--
| . |||   .|. |    | . |..|||. |.|.. ..  ||.||.||        .|   || ||......|..|| |..      | .|||   |  
rykdilpydhsrvkl....gdggsdyinAsyvdgynlkrk.fiatqgPl.......pntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggel

NLRSGPFEVRHHGFDKHRGFLVSSLSLTL--RGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRN----LKVRGPIVVHDDRGLGPSGVFVASDYCID
 |. |.| |.. . ... .. |  | ||    |...  .|..  || .|| | | .|.. .....|.    |.  ||.|||   |.| .|.|.| |...|
sltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllld

QA-QAGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
|    |.||| .||. ||. |   |..   |.......| ||
qlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

0045450 (Phosphotyrosine protein) phosphatases II 265-494 7.7e-42 139.5 In-house 60-304 (307) alignment
Range on Protein: 265-494
Range on HMM: 60-304/307.0
REPRILPSVTTRIQLDRPPGA-KISGFINANAV--------RGFQGnPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIEPQPH---RCTR
| . |||   ||..|  ..|  . |..|||. |         |.   ...||.||.||..       |   || |.....  |..|| |. ..    | .
rykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpe.......tvedFwrmlweqgvtvivmltelvelgrekcaq

YWPVPDGNLRSGPFEVRHHGFDKHRGFLVSSLSLT---LRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRN----LKVRGPIVVHDDRGLGPSGVF
|||  .. |  |.| |.  ..... |. |  | .|     |.... .|..  || .||.| | ..........|.    |.  ||..||   |.| .|.|
ywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtf

VASDYCIDQAQAGK----VDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
.| .....| ....    ||. .|| .||. |   |..   |.......| .|
iaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

0040439 (Phosphotyrosine protein) phosphatases II 265-494 8.7e-42 138.8 In-house 16-246 (249) alignment
Range on Protein: 265-494
Range on HMM: 16-246/249.0
REPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQgNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIEPQPH---RCTRYWPVpDGNL
| | |||   .|..|   ||   |..|||. . |..  ..|||.||.||..       |  .|| |.....  |..|| .....    | .|||  .| |
rypdilpydhsrvklsilpglflsdyinAsyidgyy.ikrrfiatqgPlpe.......tvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsl

RSGPFEVRHHGFDKHRGFLVSSLSLT--LRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK----VRGPIVVHDDRGLGPSGVFVASDYCIDQA
  | | |.   .... .. |  | ||    |.... .||.  .| .||.| | ..........|.        ||..||   |.| .|.|.| .....| 
eygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleql

-QAGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
   ..||. .|| .||. |   |..   |.......| .|
ekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

0043336 (Phosphotyrosine protein) phosphatases II 265-493 1.4e-41 138.2 In-house 50-276 (278) alignment
Range on Protein: 265-493
Range on HMM: 50-276/278.0
REPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQgNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIEPQPHR---CTRYWPvpDGNL
| . |||   .|..|.  .|   |..|||. | |..  |..||.||.||..       |   || ||.... ....|| |.  .    | .|||  .| |
rykdilpydhsrvklsllggdldsdYinAsyvdgyn.vprkfiatqgPlpe.......tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsl

RSGPFEVRHHGFDKHRGFLVSSLSLT--LRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNL--KVRGPIVVHDDRGLGPSGVFVASDYCIDQA-Q
. |.| |.  ..... .. |  | .|    |...  .|..  || .||.| | .... .|...|.   .  ||..||   |.| .|.|.| .....|.  
tygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlek

AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGY
 |.||. .|| .||. |.  |..   |.......| |
eggvdleeavkelreqRpgavqtpsqyrflyealley

subfamily_PTPRD_pd Subfamily PTPRD 265-498 1.5e-38 127.8 In-house 53-285 (564) alignment
Range on Protein: 265-498
Range on HMM: 53-285/564.0
REPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQgNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDgNL
|   |..  ..|. | . .| . | .|||. . |.. ..  .| ||.||.        |   || ||....  ...||    | . ..| .|||  . . 
RyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlae.......tiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.te

RSGPFEVRHHGFDKHRGFLVSSLSLTL--RGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKV--RGPIVVHDDRGLGPSGVFVASDYCIDQAQA
. | ..|  .   .   . . ...|.   . ...  ..     | .|| | | .|...|.|  |.|.   .||||||   | | .|.|.. |........
tygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerike

-GKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGKD
 ..||..| | .||..| |.|...  |..||. .| .|.  .
ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgn

subfamily_PTPRB_pd Subfamily PTPRB 265-499 2.4e-38 126.9 In-house 56-290 (293) alignment
Range on Protein: 265-499
Range on HMM: 56-290/293.0
REPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGnPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDGNL
|  .|||  ..|..|    . . | .|||| ..|..  |  ||.|| ||        .|   || ||.. .. ...||   .|    .| .|||  . . 
rytnilpydhsrvkLaalkdesgsDYinanyipgyns.prefiatqGPlp.......etvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv

RSGPFEVRHHGFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK----VRGPIVVHDDRGLGPSGVFVASDYCIDQAQA
  |  .|     .. . . . .|... . .... ..     | .|| | ..|......| .|. .     ..|||||   |.| .|.|.| |  ... . 
lyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaiee

-GKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGKDQ
   ||..  |. ||..|. || . ..| .||. || .|  |..
edyvdifgivaelReeRnllvqtekqYifihqcvldllrkkee

subfamily_PTPN12_pd Subfamily PTPN12 265-494 8.6e-36 118.3 In-house 45-277 (290) alignment
Range on Protein: 265-494
Range on HMM: 45-277/290.0
REPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNpMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVP-DGN
|   |||  ..|..| .  . . |..|||| ..| .|. ...| .|.||.        |   || |.....  .|.|.   .| . ..| ||||   . .
rykDilPydksrvelskieeeegsdYinanfikgvegk.leyiaaqgPLp.......ktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeee

LRSGPFEVRHHGFDKHR-GFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKVR--GPIVVHDDRGLGPSGVFVASDYCIDQAQA
|. |.|||  .  ..   .||. .| .. ........ .    | .|| |.| ||...|.. .|.|. .   |.|||   | |  |. .| ||  .. .|
lefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellka

GKV----DVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
.|.    || . | .||..||||| ..  |..... |. ..
ekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 265-497 2.2e-31 104.1 In-house 53-286 (319) alignment
Range on Protein: 265-497
Range on HMM: 53-286/319.0
REPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNpMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLI---EPQPHRCTRYWPVPDgNL
| . ||.   ||..|   .| . | .|||. . |.| .  .|| |||||.        |   || ||..... .|.||    |.   .. .|||  .   
ryqnilaydrtrvvlseldgvegsdyinasfidgyqer.ekfiatqaPlen.......tiedfWrmvWeeessivvmltklveklkvklkkywpeen.fe

RSGPFEVRHHGFDKHRGFLVSSLSLTLRGKT---HRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKVR---GPIVVHDDRGLGPSGVFVASDYCIDQA
. | . |     ..  .. .. |.|  .       . .|     | .|. |....|...||. .|. . .   ||||||   | |  | |.. |  ... 
eyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlerv

Q-AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGK
.  | .|| . | .||  |  .|.  . |..|.  .| ...  
keegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveag

subfamily_PTPRK_pd Subfamily PTPRK 265-492 5.5e-31 102.6 In-house 48-275 (314) alignment
Range on Protein: 265-492
Range on HMM: 48-275/314.0
REPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQgNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIEPQP---HRCTRYWPvPDGNL
|   ||.   .|..|    |   | .|||. . ... .|  ||||| ||         |   || .||....  ..|| | .     .|..|||  |.. 
rsgdilaydrsrvflitidgdpssdyinaalidsyk.rpaafivtqgPlqe.......tvkdfWrlvydencasivmltelvevgrvkClkyWP.edtev

rSGPFEVRHHGFDKHRGFLVSSLSLTL--RG--KTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK--VRGPIVVHDDRGLGPSGVFVASDYCIDQA
  |...|     . .  ..|  ....   ||  ...  ...   || .|. | | .....|.| . . .    |.||||   | | .|.|.| |  .| .
.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmi

QA-GKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLG
.  | ||| .|| |||. .  .||    |..|.  .| 
eregvvdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 265-496 1.6e-30 101.0 In-house 51-285 (290) alignment
Range on Protein: 265-496
Range on HMM: 51-285/290.0
REPRILPSVTTRIQLDRPPGAKI--SGFINANAVRGFQgNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIE---PQPHRCTRYWPVPDG
|  .|...   || | . .| |     .|||  . |.. .  ..|.||.|.|        | | ||....| . ....||..    . ..|  |||  | 
RfanivvyddnritLrpisghkDCtneyinAcyikgyk.ekkqyiatqgpvs.......ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdt

NLrSGPFEVRHHGFDKHRGFLVSSLSLTLRGK---THRFQHICLSGWNEHG-LPRSSKSVIALLRYLRN--LKVRGPIVVHDDRGLGPSGVFVASDYCID
.   |.|... .   .. ..    |... . .   ..  ..  .. |...| ..  . ..... .  ..   . ...||||   ..| |.||.| .  |.
ka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattin

QAQ-AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDG
...  | .||.| ....|. .  .|..  .||.|...|| ||| 
kcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

subfamily_PTPN3_pd Subfamily PTPN3 265-489 8.2e-29 95.4 In-house 46-270 (280) alignment
Range on Protein: 265-489
Range on HMM: 46-270/280.0
REPRILPSVTTRIQLDRPPGakisGFINANAVRG-FQ--GNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPD
|   |||  .||..|.  .      .|||| |    .  |   |.|.|| ||.        |   || ||.. .. ...||   .|    .| .||| ..
ryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPla.......ktatdfWqmvweqksslivmlttlverGrvkChqyWPete

GNLRSGPFEVRHHGFDKHRGFLVSSLSLTLRG--KTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK--VRGPIVVHDDRGLGPSGVFVASDYCIDQ
 .|. | |.|. .  |... ...  | |. .   . ..  ..    | .||.| .|.... ... .|.|.   . |.|||   |.| .||... . ..  
deleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalal

AQ-AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRL
 . | .| ... | |.|. ||.||.. . |...   
ieaaepvypldivrtmrdqramlvqtasqykfvCea

subfamily_PTPN14_pd Subfamily PTPN14 265-495 1.8e-22 74.7 In-house 54-297 (300) alignment
Range on Protein: 265-495
Range on HMM: 54-297/300.0
REPRILPSVTTRIQLDrPPGAKISGFINANAVRG-FQGNPMRFIVTQAPLsgfESgrvgTQVAFWSMVYQYQAPVVIMLIEP---QPHRCTRYWPVP---
| . .||   .|..|  |   . .|.|||  ..    |. . .||.|.||   |     |   || ||.. .  ...|| |      ... .|.|     
rfkdvlPyednrvels.ptkenstgyinassikvsvggkersyivaqgPl...el....tvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPklesk

DGNLRSGPFEVRHHGFDKHRGFLVSSLSLT--LRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKV-----------RGPIVVHDDRGLGPSGV
  ... | |.|  .  ..   .  ..| |   . ..     |.    | .||.|.  |. .  |. .. ..            . |..||   | | .||
kktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGv

FVASDYCIDQAQAG-KVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLD
 . ||  |   . . ..|. ... .||. |  ||.. | |........ ||.
lilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

0040438 (Phosphotyrosine protein) phosphatases II 266-494 1.1e-44 148.4 In-house 49-276 (317) alignment
Range on Protein: 266-494
Range on HMM: 49-276/317.0
EPRILPSVTTRIQLDRPPGAKISGFINANAVRGFqGNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIEPQPHR---CTRYWPVpDGNLR
 | |||   .|..|  ..|   |..|||. | |.   ...||.||.||..       |   || ||....  |..|| |. .     | .|||  .. | 
ypdilpydhsRVkLsplggdldsdYInAsyvdgp.nlkrkfIatqgPlpn.......tvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getlt

SGPFEVRHHGFDKHRGFLVSSLSLT--LRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNL--KVRGPIVVHDDRGLGPSGVFVASDYCIDQAQ-A
 |.| |.. ..... |. .  | ..    ..... .|..  || .||.| | ......|...|.   .  ||..||   |.| .|.|.| .....| .  
ygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqleke

GKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
|.||| .||..||. |.  |.. . |.......| ||
ggvdveeavkelreqRpgavqtpeqyrflydalleyl

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 266-496 1e-41 137.7 In-house 26-266 (270) alignment
Range on Protein: 266-496
Range on HMM: 26-266/270.0
EPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIM---LIEPQPHRCTRYWPVPDGN--
   |||| .||..|..    ... .|||| ||||.|.. ..| ...||         |  .|| |... ... ..|   | |   ..| ||||   ..  
yadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlp.......ttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

-LRSGPFEVRHHGFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSK------SVIALLRYLRNLKVRG----PIVVHDDRGLGPSGVFVASD
 |. |  .|.     |..|...  | |. .|...|  |     |..|| ||..       .....|| .|. . .     |..||.  |.| .|...| |
kledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialD

YCIDQA-QAGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDG
...    . .||||.. .  ||.|| |||.   .|..... |. | . 
iavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer

0042113 (Phosphotyrosine protein) phosphatases II 266-494 1.2e-37 125.0 In-house 15-243 (245) alignment
Range on Protein: 266-494
Range on HMM: 15-243/245.0
EPRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNPMrFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIEPQP---HRCTRYWPVpDGNLR
 . |||   ||..|  ..|   |..|||. | |.. .|  ||.||.||..       |  .|| |.....  ...|| |. .   . | .|||  .. |.
ysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpe.......tvedfwrmlwelgittivmLteeeelgrvkcaqywpl.geslt

SGPFEVRHHGFDKHRGFLVSSLSLT--LRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRN---LKVRGPIVVHDDRGLGPSGVFVASDYCIDQAQ-
 | | |.  ..... .. |  |..|    ....  .|..  .| .|| | ...... .|...|.    .  ||..||   |.| .|.|.| .....|.. 
ygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlek

AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
 ..|.. .||. ||. |   |..   |.......| .|
elgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 266-497 3.2e-27 90.2 In-house 53-281 (287) alignment
Range on Protein: 266-497
Range on HMM: 53-281/287.0
EPRILPSVTTRIQLDrppgAKISGFINANAVRGFQGNpMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIE---PQPHRCTRYWPVPDGnLR
  .||.    |. |      .   .|||  . |.. .  .||....|..        | . || .. . . ....|| .    . . | .|||  .  . 
ltqilvpdnyrvllk....gehpdyinavfidgykek.kafiiaesPmf.......ntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vv

SGPFEVRHHGFDKHRGFLVSSLSLTLRGKTHRFQHI---CLSGWNEHG-LPRSSKSVIALLRYLRNLKV--RGPIVVHDDRGLGPSGVFVASDYCIDQAQ
 |.....    ... |...  | .. ..|.   |..    .  |...| ...   ... . .  .. .   ...||||   . | |..|.| .  |....
lGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkck

-AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGK
  | .||.| .   |. .   |   ..|..|  .|| |||  
teGviDvfqvlksqriqkpgsvqtveqykfindivleyldsf

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 266-495 2.9e-22 73.8 In-house 44-278 (287) alignment
Range on Protein: 266-495
Range on HMM: 44-278/287.0
EPRILPSVTTRIQLDRPPgAKISGFINANAVRGFQGNpMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDGNLR
   .||   ||. |   .  . | .|||| | ... .  .||..|.|..        |   || .|.. .. .||..   .|    .| .||| ..  .|
yadvlPiddtrvllsaeg.elGsdyinanyvasytdd.eafiaaqgPiaa.......tvrdfwravletrsasvitmtreveearlkcykywPerevPmr

SGPFEVRHHGFDK-HRGFLVSSLSLT-LRGKT-HRFQHICLSGWNEHGLPRSSKSVI----A---LLRYLRNLKVRGPIVVHDDRGLGPSGVFVASDYCI
 | . |    .|. .  . | .| |  | ..  .  . . |  | ...|. .. ..|         .   |. .  ||.||||| |.| ||...|   ..
vGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv

DQA-QAGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLD
..  . |.||| ..|  ||. ||||| .   ....   .  |  
srledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk

0045098 (Phosphotyrosine protein) phosphatases II 267-496 4e-39 130.1 In-house 40-274 (278) alignment
Range on Protein: 267-496
Range on HMM: 40-274/278.0
PRILPSVTTRIQldrppgakisGFINANAVRGFqgnPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIEPQPH---RCTRYWPvPDGNLRS
. |||   .|.           ..|||. ..|.   |..||.||.||         |  .|| |..... .|..|| | ..     | .||| ..| |. 
kdilpydhsrVk..........dYINAsyidgy...pkkfIatqgPlp.......stvadfwrmlwelgitvivmltelvelgrekcaqywp.eggslty

GPFEVRHHGFDKHRGFLVSSLSLT------LRGKTHRFQHICLSGWNEHGLPRSS--KSVIALLRYLRNLK---------------VRGPIVVHDDRGLG
|.|.|.   .. .  . .  | .|        .... ..|... .| .|| | ..  ||.. ||...|.                   ||..||   |.|
gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvg

PSGVFVASDYCIDQAqAGKVDVMQAVYTLRQDRAA-LVESRAEYQYIHRLVLGYLDG
 .|..|| ......   |.||. .|| .||. |    |..   |.......| .|  
RtGtlvaaylmlell.eggvdlleavkelrsqRpglavqnleqyrflyefllelllr

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 267-496 4.6e-24 80.1 In-house 55-291 (325) alignment
Range on Protein: 267-496
Range on HMM: 55-291/325.0
PRILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNPMrFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML--IEPQPHRCTRYWPVPDG-NLRS
. ...   .|. |     .  | .|||. .| ...  . |. .||||.        |   .| .|......||..|  .. . .||. |||   |   . 
knvvaldksrvvletkkddpssdyinasylrddkkkdv.flaaqaPlt.......atindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktf

GPFEVRHHGFDKHRGFLVSSLSL--TLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRN--------LKVRGPIVVHDDRGLGPSGVFVASdYCI-
|..||.    ..   ..   | .  . .|.|   .   | .|.. | ..   ..|..|. . .         |  .||.||   |.| .|||..  |.. 
GglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfisl.ysal

DQ-AQAGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL-DG
..  .  .||... |  ||.|| ..||.  .|  |.  .  ..  |
akvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsg

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 268-496 2.4e-35 116.9 In-house 17-244 (250) alignment
Range on Protein: 268-496
Range on HMM: 17-244/250.0
RILPSVTTRIQLDRPPGAKISGFINANAVRGFQGNpMRFIVTQAPLsgfesgrVGTQVAFWSMVYQYQAPVVIMLI--EPQPHRCTRYWPVpDGNLRSGP
 |..   .|. | .  | |.| .|||  . |....   ||.||.||       . | . || ||..... ...||   . . . ...|||| ..  . | 
diialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPl.......qatiedfWrmvleeksgtivmLtnLkesektyhqywPv.ekaekyGd

FEVRHHGFDKHRGFLVSSLSLTLRGKTHR--FQHICLSGWNEHGLPRSSKSVIALLRYLRNLKVR---GPIVVHDDRGLGPSGVFVASDYCIDQAQAG-K
  |  .  ...  . .  | |. . |...   ...    | . | |.  ..|..||. ..  . .   .|..|.   | | || |.| |  .....   .
vtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekv

VDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDG
|||.. . .||.||   |||.. | ......| .|| 
vdvfkvikvlrkdrphavesleqyvfvyeiilkalds

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 268-494 1.2e-31 105.2 In-house 69-292 (319) alignment
Range on Protein: 268-494
Range on HMM: 69-292/319.0
RILPSVTTRIQLDRPPGAKISGFINANAVRGFQGnPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIepqPHRCTRYWPVpDGNLRSGPFE
.||.   ....|.|  |   | .|||  | |.|  . ..| .| ||         |   || |...|..  ...|     ..|..|||  ... . . |.
nilafdknvvklerliGeefsdyinasfvtGyqr.kdkyiaaqGPld.......ntladfWrmiweyncstivllt...kdkcsqywpl.kivikeerfk

VRHHGFDKHRGFLVSSLSLTLRGKTHRFQHI---CLSGWNEHGLPRSSKSVIALLRYLRNL----KVRGPIVVHDDRGLGPSGVFVASDYCIDQAQA-GK
|. .  ..   . | .. |.  || .  ..|    . || ..| | ..  .. |.. .| |    . | .||||   | | .||... |  .|. .   .
vkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekq

VDVMQAVYTLRQDRAALVESRAEYQYIHRLVLG-YL
||| . |  |||.|  ||.. ..|..|.  .|  .|
vdvynfvrdlrqqrntlvqdlvqykfiysalleehl

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 268-494 1.8e-31 104.7 In-house 33-256 (284) alignment
Range on Protein: 268-494
Range on HMM: 33-256/284.0
RILPSVTTRIQLDRPPGAKISGFINANAVRGFQGnPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIepqPHRCTRYWPVpDGNLRSGPFE
.||.   ....|.|  |   | .|||  . |.|  . ..| || ||         |   || |...|..  ...|     ..|..|||  ... . . |.
hilafdknvvklerliGeefsdyinasfitGyqr.kdkyiatqGPld.......ntladfWrmiweyncstivllt...kdkcsqywpl.kivikeerfk

VRHHGFDKHRGFLVSSLSLTLRGKTHRFQHI---CLSGWNEHGLPRSSKSVIALLRYLRNL----KVRGPIVVHDDRGLGPSGVFVASDYCIDQAQA-GK
|. .  ..   . | .. |.  || .  ..|    . || ..| | ..  ...|.. .| |    . | .||||   | | .||... |  .|. .   .
vkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekq

VDVMQAVYTLRQDRAALVESRAEYQYIHRLVLG-YL
|||.. |  |||.|  ||.. ..|..|.  .|  .|
vdvynfvrdlrqqrntlvqdlvqykfiysalleehl

subfamily_PTPN13_pd Subfamily PTPN13 268-493 1.3e-29 98.4 In-house 45-268 (273) alignment
Range on Protein: 268-493
Range on HMM: 45-268/273.0
RILPSVTTRIQLDRPPGakisgFINANAVRGFQG-NPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLI---EPQPHRCTRYWPVPDGN-L-
 .||   ||..|.   |     .|||. ..   | .  ..|..| ||         |   || ||.. .| |..|.    | .  .| ||||.  .. | 
nvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlP.......etvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklk

RSGPFEVRHHGFDKHRGFLVSSLSLT--LRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKV-RGPIVVHDDRGLGPSGVFVASDYCIDQ-AQA
 |. .||.  .  |. || |..| ..    |.... .|. .  | .|| |.|..... .....|.|.  .||||||   |.| ||.... |  ..  .. 
vsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierd

GKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGY
 ..|| . | .||. | ..| ..  | .... .|  
kefdvkeivrklreqrqgvvqtkdqyifvykailev

subfamily_PTPN6_pd Subfamily PTPN6 268-498 7.2e-29 95.7 In-house 62-301 (306) alignment
Range on Protein: 268-498
Range on HMM: 62-301/306.0
RILPSVTTRIQLDrPPGAKISGFINANAVR-GFQGNPMRFIVTQAPLsgfesgrVGTQVAFWSMVYQYQAPVVIMLI---EPQPHRCTRYWPVPDGNLRS
 |||   ||. |   |. . | .|||| ..  ..|.  ..| ||  |         |   ||.||.| .. |..|.    |   ..|.||||    . . 
nilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgcl.......ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeey

GPFEVRHHGFDKHRGFLVSSLSLT---LRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRN--LKV----RGPIVVHDDRGLGPSGVFVASDYCIDQ
|  .|..   .... . . .||..     .....  .     | .|| |.. . |...|. ...   ..     ||||||   |.|  | |.  |  ...
GkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkl

AQAG----KVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDGKD
 .      ..|. ..| ..|. |  ||   . |..... .  |.. | 
iekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 269-492 2.7e-27 90.5 In-house 58-277 (315) alignment
Range on Protein: 269-492
Range on HMM: 58-277/315.0
ILPSVTTRIQLDRPPGAKISGFINANAVRGFQgNPMRFIVTQAPLsgfesgrVGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPvpDGNLRSGP
|..   .|.||      . | ..||| . |..  . |.| .|.|.       | .   || .|....   ..||   .| . ... .|||  | ..  |.
iiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpn.......vasvkdfwrlvfeedigkivmltnlvegekrkaekywp..dkkviyGk

FEVRHHGFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK--VRGPIVVHDDRGLGPSGVFVASDYCIDQAQAGK-VDV
. | .   ...  . | .|| . . . .    . .. | . |.|... ... | |  .  .    |.|||| . | | .| |.. |  .|||.| . .||
itvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidv

MQAVYTLRQDRAALVESRAEYQYIHRLVLG
 ...  .|| |  .|.. ..||.|.  .| 
ynfitgvrqnrikmvqvaeqyqfiydalle

subfamily_PTPN1_pd Subfamily PTPN1 269-484 1.8e-20 67.9 In-house 41-261 (290) alignment
Range on Protein: 269-484
Range on HMM: 41-261/290.0
ILPSVTTRIQLDRPPGakisGFINANAVRgFQGNPMRFIVTQAPLsgfesgrVGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDG----NL
. |   .||.|.|        .|||. |  ..    ..|.|| ||       . |   || ||.. ..  |.||   .| .  .|..|||  .      |
vspydhsrikleradn....dyinaslve.leeakrsyiltqGPl.......pntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekelll

RSGPFEVRHHGFDKHRGFLVSSLSLTL--RGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK----VRGPIVVHDDRGLGPSGVFVASDYCIDQA
    ..|.    .... . |. | |.     .|.   |     |.. |.|.|  . . .|  .|.        || |.|   |.| || |.  | |. . 
edtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvli

QA----GKVDVMQAVYTLRQDRAALVESRAEYQ
..      ||. . .  ||. |  |.      .
ekkddlssvdikkvllelrkyrlGliqtadqlr

subfamily_PTPN9_pd Subfamily PTPN9 273-494 1.3e-28 94.9 In-house 55-290 (297) alignment
Range on Protein: 273-494
Range on HMM: 55-290/297.0
VTTRIQLDRPPGAKISGFINANAVRGFQgNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDG-NLRSGPFEV
  ||..| . .. . | .|||| | |.. ..  || || ||         |   || ||.. .. |..|    .| .  .|..|||  ..   . | ..|
detrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplk.......ktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsv

RHHGFDKHRGFLVSSLSLT--LRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLK--------------VR-GPIVVHDDRGLGPSGVFVASDYC
..   .... . |..| ..    ... .  |  . .| ..| |.|..|.. .|.  |. .              ..  |||||   |.| .| |.. |.|
snveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldic

IDQAQ-AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
... .  |.|||...| .||. ||  .     |.. .  || | 
lsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 274-496 2e-34 114.0 In-house 55-278 (281) alignment
Range on Protein: 274-496
Range on HMM: 55-278/281.0
TTRIQLDRPPGAKISGFINANAVRGFQGnPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDGNLRSGPFEVRH
 ||... .   .| . .|||| | |..| . ..|.||.|.         . |||| ||..... ...|.   ||    .| |||| .. .|. | . |..
atrvkvtpneenkntDYinanfvpgykg.ekeyiatqgPvP.......aslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvks

HGFDKHRGFLVSSLSL-TLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRN---LKVRGPIVVHDDRGLGPSGVFVASDYCIDQA--QAGKVDVMQ
.   ... ..   ..| .  |.| . ...    | .|| | ..| ..   . ...    |   |.|.|   | | .|...| |  ....  .. ..|| .
taeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvka

AVYTLRQDRAALVESRAEYQYIHRLVLGYLDG
 |  ||..|  .| . . |..... || .|| 
vvaelrkernlmvqtvvqyefvykavldaldk

0044763 (Phosphotyrosine protein) phosphatases II 274-490 1.3e-16 56.3 In-house 4-167 (178) alignment
Range on Protein: 274-490
Range on HMM: 4-167/178.0
TTRIQLDRPPGAKISGFINANAVRGFqgnpmrFIVTQAPLsgfesgrvgtqVAFWSMVYQYQAPVVIMLIEPQP---HRCTRYWPVPDGnlrsgpfevrh
 ||  |. ..|   | .|||. . ..      ......|            .... .....   ....| |...   . | .|||   |           
rtrvllsnleglersdyinaseilpg......lylgslpp...........addlellkelgithivnlteelelgflkcdpywpeeag...........

hgfdkhrgflvsslsltlrgkthrFQHICLsGWNEHGLPRSSKSVIALLRYLRNL--KVRGPIVVHDDRGLGPSGVFVASDYCIDQaqagKVDVMQAVYT
                        .|.... ..  || | ... . .........  .  ||..||   |.| ||..|| .... .    .... .|.  
........................iqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....glsleeaiel

LRQDRAaLVESRAEYQYIHRLV
.|. |   |...  ....... 
vrerRp.ivpnpgqlrqLyefe

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 274-492 3e-16 53.9 In-house 62-277 (439) alignment
Range on Protein: 274-492
Range on HMM: 62-277/439.0
TTRIQLDRPPGAKISGFINANAVRGFQGnPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIEPQphRCTRYWPVpDGNLRSGPFEVRHHGF
 ||. |.  ||   | .|||| ..|.   .  .| ||.|          |   || .|.. ..  ..|| .       .|||  |..   |   ||    
htrvtlqeipgvphshyinanyikGyyd.dklyiatqgpkk.......ettddfwrlviekktvtivmltnlv..esykywps.daevcygdiavrvdrn

D-----KHRGFLVSSLSLTLRgKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLR---NLKVRGPIVVHDDRGLGPSGVFVASDYCIDQAQA-GKVDVMQ
        ||| |     | . | .   ..    | .. .|  .  |. .|| .    . .  ||.|||   |.| .|  .| | ...| ..  |||.  
ielpnyvirgfkvfnerdtte.kertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikg

AVYTLRQDRAALVESRAEYQYIHRLVLG
 |  ||..|  .|.. ..| .|.  || 
ivkvlrkqrkqmvqalcqyvfiynavle

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 275-491 1.8e-24 81.3 In-house 18-236 (237) alignment
Range on Protein: 275-491
Range on HMM: 18-236/237.0
TRIQLdRPPGAKiSGFINANAVRGFQGNPMRFIVTQAPLsgfESgrvgTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDGNLRSGPFEVRHH
.|. | . .|.. | .|||. ..||.| | ..| .| ||   ||    .   || ||.| .  |..||   || .  .| .|||  |     | . |  .
srvvl.kgagsg.sdyinatylkgfdgtpkkyiaaqgpl...es....scddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslk

GFDKHRGFLVSSLSLTLRGKTHRFQHI---CLSGWNEHGLPRSSKSVIALLRYLRNLK----VRGPIVVHDDRGLGPSGVFVASDYCIDQAQAGK-VDVM
  ..   . | || |. |.. .  . |    .. | ..|.|. . ... . . . |        || ..|   |.| .|.|.  |  . ||.  | ||. 
kkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiy

QAVYTLRQDRAALVESRAEYQYIHRLVL
. ||.. .||  ..... .| .||. .|
nyvysieedrpyiiqtkdqyvfihqtil

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 275-495 7.6e-15 49.7 In-house 58-272 (288) alignment
Range on Protein: 275-495
Range on HMM: 58-272/288.0
TRIQLDrppgAKISGFINANAVRgFQGNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDGN---LRSGPFEV
||..|.         .|.|| |   . .. |.| .||||        ||   .| |. . .   ..||   .|   ..   |.|.  |.   ..     |
trvkls....ddpdfyiaanvvs.sakykrrlicaqaPln.......gtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvv

RHHGFDKHRGFLVSSLSLTLRGKTHR-FQHICLSGWNEHGLPRSSKSVIALLRYLRNLKvrGPIVVHDDRGLGPSGVFVASDYCIDQAQA-GKVDVMQAV
...  | ..   || |  .  |...   ... |  |...|.| . .| . ||  |..|.   |||||   | | .| .. .   .....    . . . .
kkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq..kPivvhssaGvGrtgtlililialeslrlddflgirsll

YTLRQDRAALVESRAEYQYIHRLVLGYLD
  ||..|   ...   | |.||.|| .| 
aklreerfkaiqtemqylyvhrcvleell

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 275-493 8.8e-14 45.8 In-house 52-268 (281) alignment
Range on Protein: 275-493
Range on HMM: 52-268/281.0
TRIQLDR-PPGAKISGFINANAVRGFQGNpMRFIVTQAPlsgfesgRVGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVP-DGNLRSGPFEVR
.|.||    |  . . .| || .|    .   .|.|| |       .  |.  || |..| ..  ..||   .| .  .|. |.|      |.   . | 
srvqlkvkmpnknstdyihanyirspflk.rgyiltqgp.......kketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvs

HHGFDKHRGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKvrGPIVVHDDRGLGPSGVFVASDYCIDQAQA--GKVDVMQAVY
.      . .. . | |.  |.|.   |     | .  .| ||. .. .|| .|      | |.|   |.| || ..| . ...  ..     |. | | 
yedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirars..tppvihcsagvgrsgtlmaveialqsihshftlpdikqivs

TLRQ-DRAALVESRAEYQYIHRLVLGY
 ||   ||| |..  .|  | ...| .
hlrvtgraasvqtlqqymliwkvlldf

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 276-494 3e-22 74.0 In-house 57-277 (307) alignment
Range on Protein: 276-494
Range on HMM: 57-277/307.0
RIQLDRpPGAkISGFINANAVrGFQGNPMRFIVTQAPLSgfeSgrvgTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDGNLR-----SGPFE
|| .   .|.  | .| || . |   .| .||..| ||    .    ||  ||.|. | .   ||||   ||    .| .|||. .|.       .    
rivvkf.dgl.asdyihanyl.giaikpkkficaqgple...n....tqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntis

VRHHGFDKH----RGFLVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNlkVRGPIVVHDDRGLGPSGVFVASDYCIDQAQAGK--VD
|   | .|         |..| .   .|.   ||.  . | ..| |.   . | ||   |    . |.|||   |.| ||  ||  .  |.  ||.   |
vanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry..dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckd

VMQAVYTLRQDRAALVESRAEYQYIHRLVLGYL
. . |  ||..|   ... |.| |.||..| |.
mkklveelrsqrhyaiqteaqylylhrvlleyf

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 276-491 2.8e-19 64.2 In-house 23-237 (239) alignment
Range on Protein: 276-491
Range on HMM: 23-237/239.0
RIQLDRPPGAKISGFINANAVRGFQGNPMRFIVTQAPLSgFESGrvgtqvAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPvpDGNLRSGPFEVRHHG
|. |..      | .|||. .| ..|.|  .| ||  ..  .||       || |..| .  |..||   || . ..| .|||  |   .   . |  . 
rvvleklsndphsdyinasylrdydgspkayiatqgcve.issg......dfwrmmwqerrcvivmltglieghkkkchqywp..dstskycnlrvtlrk

FDKHRGFLVSSLSLTLRGKTH-RF-QHICLSGWNEHGLPRSSKSVIALLRYLRNLKV--RGPIVVHDDRGLGPSGVFVASDYCIDQAQAGK-VDVMQAVY
 .    ... .. ..  |.|  |.  .  .. | ..|.|. . .|. | | . .  .    | |.|   |.| .| |.  |  . ||.  | ||... | 
tevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvk

TLRQDRAALVESRAEYQYIHRLVL
..|.||  .|..  .| .||  ||
airedrphmvqtseqyvfihlavl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 276-491 3.2e-19 64.0 In-house 24-238 (239) alignment
Range on Protein: 276-491
Range on HMM: 24-238/239.0
RIQLDRPPGAKISGFINANAVRGFQGNPMRFIVTQAPLSgFESGrvgtqvAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPvpDGNLRSGPFEVRHHG
|. |..      | .|||. .| ..|.|  .| ||  ..  .||       || |..| .  |..||   || . ..| .|||  |   .   . |  . 
rvvleklsndphsdyinasylrdydgspkayiatqgcve.issg......dfwrmmwqerrcvivmltglieghkkkchqywp..dstskycnlrvtlrk

FDKHRGFLVSSLSLTLRGKTH-RF-QHICLSGWNEHGLPRSSKSVIALLRYLRNLKV--RGPIVVHDDRGLGPSGVFVASDYCIDQAQAGK-VDVMQAVY
 .    ... .. ..  |.|  |.  .  .. | ..|.|. . .|. | | . .  .    | |.|   |.| .| |.  |  . ||.  | ||... | 
tevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvk

TLRQDRAALVESRAEYQYIHRLVL
..|.||  .|..  .| .||  ||
airedrphmvqtseqyvfihlavl

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 277-503 4.7e-20 66.4 In-house 72-299 (305) alignment
Range on Protein: 277-503
Range on HMM: 72-299/305.0
IQLDRPPgakISGFINANAVRGFQGNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDGN---LRSGPFEVR-
..||.|.    | .| || |        |||..| ||         |   || || | .   ..||   .|    .|..|||.  |.   |.||      
vkldkps...psdyihanyvgcpmipekrficaqgpldq.......tidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenv

--HHGFDKHRGFLVSSLSLTL-RGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKVrgPIVVHDDRGLGPSGVFVASDYCIDQAQAGK-VDVM-Q
   . ...     .. | ||   ...   .|.  . | . |.|    . . ||  .|  ||  |||||   |.| .|  || .| ...    | .  | .
sgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskv..pivvhcsagigrtgtivaieyilekiaenkpcppmpe

AVYTLRQDRAALVESRAEYQYIHRLVLGYLDGKD-QKGAA
 | .||..||  ...  .| .|||..| |.  |  .| ||
lvkalrdqrafsiqndvqylfihrvmlnyflekykekyaa

0041856 (Phosphotyrosine protein) phosphatases II 287-494 5.4e-22 73.7 In-house 18-171 (182) alignment
Range on Protein: 287-494
Range on HMM: 18-171/182.0
ISGFINANAVRGFQGNPMrFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIepqphrCTRYWPvpdgnlrsgpfevrhhgfdkhrgflvsslsl
 . .|||| ..| . .   ||.||.|| .       |  .|. |.....  ....|       . .|||                               
dldyInanlylgslpatr.fiatqgplls.......tvadflrmlkelgittivnlt......eelywp...............................

tlRGKTHRFQHICLSGWNEHGLPRsSKSVIALLRYLRNlkVRGPIVVHDDRGLGPSGVFVASDYCIDQaqagKVDVMQAVYTLRQDRAALVESRAEYQYI
     ..   ...  .|  || |    .......  ..    ||..||   |.| .|..|| .... .    .|.. .|| ..|. |   |..   |...
..ellerlgiqylylpwpDhgvpd.ldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkkl....gvsleeavklvrsrRpgmvitpnqyffl

HRLVLGYL
....| .|
qlallell

0051429 (Phosphotyrosine protein) phosphatases II 287-495 1.9e-21 72.4 In-house 3-226 (272) alignment
Range on Protein: 287-495
Range on HMM: 3-226/272.0
ISGFINANAVRGFqGN---PMRFIVTQAPLSGfesgrvgTQVAFWSMvYQYQAPVVIMLIEPQ---PHRCTRYWP-----------VPDGNLRSGPFEVR
.|| |||. | |. |.   | |.. ...||         |.  || . ....  ....| ..     . | ||||             .   . | . |.
lsgyiNardvggy.grvvkpgrlyrsggplpl.......taadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvt

HHGFDKHRGFLVSSLSLT---LRGKTHRFQHICLSGWNEHGLPRSSksVIALLRYLRNlkvRGPIVVHDDRGLGPSGVFVASDYCIDQAQ-AGKVD----
.. .  .  ...  | ||     |..... |.   .|  || |...  ...||..|..    ||..||   | . .|..|| .... .      ||    
llseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYll

----VMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLD
    . .||  ||. |.. |.. . |..... .| .|.
tnlyleeaveelraqrpgavqteeqylflyeallellr

0051082 (Phosphotyrosine protein) phosphatases II 287-489 2e-18 61.9 In-house 2-148 (151) alignment
Range on Protein: 287-489
Range on HMM: 2-148/151.0
ISGFINANAVRGFqgnpmrFIVTQAPLSgfesgrvgtqvAFWSMVYQYQAPVVIMLIEPQ-PHRCTRYWPVPDgnlrsgpfevrhhgfdkhrgflvssls
.|..||.. | |.      ......||.           .|. ......  ....| ... .  |..|.|  .                           
lsdyinfsyvtgg......lyrsggpla...........dflellkelgiktivnlrseeergycpeylpelg...........................

ltlrgktHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNlkV-RGPIVVHDDRGLGPSGVFVASDYCIdQAqagkVDVMQAVYTLRQDRAALVESRAEYQ
       ... || . .| ..||| | ..|...|..|..     ||..||   |.| .|..|| . .. .     |.. .|.  .|. |  .| .  ...
.......ievlhipildwpdpglplsfdavleflellld..kkngpvlvHCsaGkgRTGtlvalylml.lg....vsleealeeyrlkrpgvvqpnqqfl

YIHRL
.... 
fqlfa

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 288-491 6.9e-21 69.6 In-house 46-256 (290) alignment
Range on Protein: 288-491
Range on HMM: 46-256/290.0
SGFINANAVRgfQGNPMRFIVTQAPLSGFESGRVGTQVAFWSMVYQYQAPVVIMLIE---PQPH----RCTRYWPVPDG-NLRSGPFEVRHHGFDKHRGF
...| || |     | .|.|.||.|.    . |  |   || |. | ..  |.|| |   ....     |..| |   | .|. . ..|.     |. ..
ddyiHAnrvt..cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddv

LVSSLSLTLR-GKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRnlKVRGPIVVHDDRGLGPSGVFVASDYCIDQAQ--AGKVDVMQAVYTLRQDRAAL
 .  | ..   .. . ..|  |.|||.   ....|....|.....  . . |..||.  |.  | .. |..          |.| . .....||. || .
etRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk..asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqrala

VESRAEYQYIHRLVL
. |  |. ..   ..
itsalelafvdagiv

0043147 (Phosphotyrosine protein) phosphatases II 288-487 5.2e-18 60.8 In-house 5-154 (172) alignment
Range on Protein: 288-487
Range on HMM: 5-154/172.0
SGFINANAVRGFQgNPMRFIVTQAPlsgfesgRVGTQVAFWSMVYQYQAPVVIMLIEPqphrctrywpvpdgnlrsgpfevrhhgfdkhrgflvsslSLT
| .|||. . .    |.|||.||.|          |   || |.....  ....| |                                         ..
sdyinasyldlyy.ipdrfiatqgp.......lrntladfwrmlkelgithivnltel.......................................lyd

LRGKTHRFQHICLSGWNEHGLPrSSKSVIALLRYLRN---LKVRGPIVVHDDRGLGPSGVFVASDYCIdqaqaGKVDVMQAVYTLRQDRAALVESRAEYQ
  . ..   ...  .|  || | ... .. .|.....   |.  ||..||   |.| .|..|| ....      .... .|| ..|. |   |..   |.
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lglsleeavalvrekRpgavqnpsqyr

YIH
...
fly

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 288-498 3.5e-17 57.1 In-house 73-291 (305) alignment
Range on Protein: 288-498
Range on HMM: 73-291/305.0
SGFINANAVRGfQGNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDGNLRS---------GPFEV-RHHGFD
  .| || |     || ||| |||||         |   || | .| .   ..||   .|   ..|. |..  |..  .           ||      | 
heyihanyvst.ptnpkrfictqaple.......ktcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfr

KHRGFLVSSLSLTLRGK---THRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKvrGPIVVHDDRGLGPSGVFVASDYCIDQAQAGKV--DVMQAVYTL
|.    |.   |.. |    ... .|     | . |.| .  ... ||   | .|  ||||||   |.| .|  |  .| .||  ||..  |  . .  .
kdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk..gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqki

RQDRAALVESRAEYQYIHRLVLGYLDGKD
|..|   ... |.| ..|...| |.  |.
reqrnnsiqtdaqylfvhqvilnyfrkkk

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 288-495 2.8e-16 54.1 In-house 70-294 (301) alignment
Range on Protein: 288-495
Range on HMM: 70-294/301.0
SGFINANAVRGFQgNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIEPQPH---RCTRYWPVPD-GNLRSGPFEVRHHGFDKHRGFLVSS
  .|||. . |.. .  .||..|.|.         | | || ...|..   ..|. . .     .|..|||  .  . . |||.|  .    .  |.. .
reyinasyidgys.ekkkfiaaqgpmk.......ktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirq

LSLTLRGK-----THR------------FQHICLSGWNEHGLPRSSKSVIALLRY--LRNLKV-RGPIVVHDDRGLGPSGVFVASDYCIDQAQA-GKVDV
|.....       ..|               . .  | ..|. |  . |.  .     |. |.  ||.|||   . . |||... .  ..|..| | |||
lnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdv

MQAVYTLRQDRAALVESRAEYQYIHRLVLGYLD
.| . ..|. .   |     |  |.  .  || 
fqvtkavrrskpgaVtTLeqytsiydvidmylq

subfamily_eak_pd Subfamily eak 288-425 7.9e-10 32.6 In-house 78-210 (332) alignment
Range on Protein: 288-425
Range on HMM: 78-210/332.0
SGFINANaVRGFQGNPMRFIVTQAPlsgfESGRVgtqVAFWSMVYQYQAPVVIMLIEP---QPHRCTRYWPVPD-GNLRSGPFEVRHHGFDKHRGFLVSS
 |.|||  .  |     ..|.| ..    .  .|    ||| ||.. ..| ...|.|    .  .  .|.|     .|. | ..|    | |.  . .  
lGyinas.laefsevGrkyiltGia....sedkv...fafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrl

LSLTLRGKTHRFQHICLSGWNEHGLPRSsKSVIALLRYLRNL
| |.   .||| .|  . || |  ||.  .  .|| . ... 
lelskGnethrvlhykvfGwtettlpky.edflalrkvmkev

0036282 (Phosphotyrosine protein) phosphatases II 289-488 5.2e-25 83.5 In-house 3-164 (174) alignment
Range on Protein: 289-488
Range on HMM: 3-164/174.0
GFINANAVRGFQGNPmRFIVTQAPLSgfesgrvgtqvaFWSMVYQYQAPVVIMLIEPQPHR---CTRYWPVpdgnlrsgpfevrhhgfdkhrgflvssls
 .|||. . ..  .| |.|..|.||.            || |.....  .|.||.|...     | .|||                              
dyinaspldlsyitp.rliagqgpla............fwemlkelgittvvmlleekelglykcinywpe.............................

lTLRGKTHRFQHICLSGWNEHGLPRSSKsVIALLRYLRNLKVR---GPIVVHDDRGLGPSGVFVASDYCIDQAQAGKVDVMQAVYTLRQDRAALVESRAE
 .    ..   ...  .|  || | .|. .. .......   .   ||..||   |.| .|..|| .... .   . ||... |..||. |   |..   
.lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQ

YQYIHR
|.... 
yrflyy

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 289-493 1.9e-19 64.4 In-house 82-282 (290) alignment
Range on Protein: 289-493
Range on HMM: 82-282/290.0
GFINANAVRGFQgnPMrFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDGN-LRSGPFEVRHHGF-DKHRGFLVSS
 .. || |.| .  .| ||.|| .|         | . .| || | .. ...||   ||    .| .|.|  .|. |  | . |      ||        
dyvhanyvkGlk..am.filtqGalk.......dtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikkt

LS--LTLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRnlKVRGPIVVHDDRGLGPSGVFVASDYCIDQAQAGK-VDVMQAVYTLRQDRAALVESR
||      || |...|. .  | .. .. |. ... .|| ||  |. ||.|||   |.| .| ||| . ...    || .|... | .||. |.. |.  
lsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilr..kasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvd

AEYQYIHRLVLGY
 .|  . ...| .
iqylalveilldl

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 289-497 1.1e-17 59.0 In-house 58-262 (267) alignment
Range on Protein: 289-497
Range on HMM: 58-262/267.0
GFINANAVRGFQGNpMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIMLIEPQPHRCTRYWPVPDGNLRSGPFEVRHHGFDK-HRGFLVSSLSLT
 .|||  | |.. .   ||||| ||.        |.  |. .. ... ||...|         ..||   |. .     .  | ..|    . . .| | 
eyinasyvegyktk.nafivtqdplk.......ntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelk

LRGK-THRFQHICLSGWNEHGLPRS-SKSVIALLRYLRNLKVRGPIVVHDDRGLGPSGVFVASDYCIDQAQ-AGKVDVMQAVYTLRQDRAALVESRAEYQ
.. . .|         ||     .   | ....|   .  .   |.||. . |.| || |.  |  ...|.  | .|. . .  .|. | .||... .| 
fknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryi

YIHRLVLGYLDGK
|||.|.  | .|.
yihellaeyaegr

0046846 (Phosphotyrosine protein) phosphatases II 290-493 5.2e-18 60.9 In-house 14-172 (176) alignment
Range on Protein: 290-493
Range on HMM: 14-172/176.0
FINANAVRGFqgnpmRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIMLIEPQ---PHRCTRYWPVpdgnlrsG----Pfevrhhgfdkhrgflvs
.|||| . |      |.|.||.|| .       |  .|. |.....  .|..| |..    ..|..|||.                              
yinanlilgs.....rpiatqgplpr.......tladflemlkelgitavvnlteevelgrlkcpnywpe.......leklgi.................

slsltlrgkthrfqHICLSGWNEHGLPRSsKSVIALLRYLRNLKVRG-PIVVHDDRGLGPSGVFVASDYCIDQaqaGKVDVMQAVYTLRQDRA-ALVESR
              ...  .| .|| | . . .. ||...|.   .| |..||   |.| .|..|| . .. .     ..| .|....|. |    |...
..............qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllele...kglsveealalvreqRplgavqtp

AEYQYIHRLVLGY
. |..... .| .
eQyrflyefelll

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 290-486 9e-11 35.8 In-house 63-280 (302) alignment
Range on Protein: 290-486
Range on HMM: 63-280/302.0
FINANAVRgFqgNPMRFIVTQAPLSGFESGRVGT----------QVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPV-PDGNLRSGPFEVRH-----
||||| .. .  . ...|..| |. | |  .  .          .  .|... ||.  .|. |   .| . ..|. |.    .|.|. | . |.      
finanvlk.l..deikwimaqGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvkt

--HGFDKHRGFLVSSLSLTLRGKTHRF----QHICLSGWNEHGLPRSSKSVIALLRYLRNLKVRgpIVVHDDRGLGPSGVFVASDYCIDQAQAGKV-DVM
  . |   ..| . .. ..   |...     . .  |.| .|| |. ... . .|..    |    ..||   |.| .| .||  | |.  .  || |..
dleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesykkn..vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdll

QAVYTLRQDRAALVESRAEYQYI
. |  .|| |   | .     |.
sivlpvrqcryGavqdeqqliyl

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 291-481 1.1e-16 55.4 In-house 78-268 (301) alignment
Range on Protein: 291-481
Range on HMM: 78-268/301.0
INANAVRGfQGNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVP-DGNLRSGPFEVRHHGFDKHRGFLVSSLSL
| || .   .|.| |||.||.||.        |.  || |. ||.   ..||   .| . ..|. | ||    .|. | |... .  ..     .|  .|
ihanwipt.sGhphrfiatqgPlk.......ntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtl

TLRGKTHRF-----QHICLSGWNEHGLPRSSKSVIALLRYLRnlKVRGPIVVHDDRGLGPSGVFVASDYCIDQAQAG-KVDVMQAVYTLRQDRAALVESR
 ..  | .|      |   | | ..|.|.|   .  |.  ..  | . |||||   |.| |  |....|   . .|  .... .|.  ||..|   |  .
evedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvk..ksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtn

A
 
s

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 293-497 4.6e-09 30.6 In-house 64-273 (285) alignment
Range on Protein: 293-497
Range on HMM: 64-273/285.0
ANAVRGFQGNPMRFIVTQAPLSGfesgrvgTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDGNL-RSGPFEVRHHGFDK--HRGFLVSSLSL
|. .|    .   .| || ||         |   || |.|| .   |.||   .|    .|. |.|   |.. . | .|.      .    | .. .|..
aswmrmpgkdqstyittqgplpe.......tlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltv

TLRG----KTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKVR-GPIVVHDDRGLGPSGVFVASDYC-IDQAQAGKVDVMQAVYTLRQDRAALVESR
.       .   ..|. .  | ..  |  .. .| | ....... .  ||.||   |.| .  ||  ||. |   .  ...... |  .|  |   |.|.
intedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqsh

AEYQYIHRLVLGYLDGK
 .. ... ... |. |.
mqflflyvvlmeyfige

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 301-498 3.1e-09 30.9 In-house 79-280 (312) alignment
Range on Protein: 301-498
Range on HMM: 79-280/312.0
GNPMRFIVTQAPLSgfesgrvGTQVAFWSMVYQYQAPVVIML---IEPQPHRCTRYWPVPDG--NLRS--------GPFEVRHHGFDKHrGFLVSSLSLT
 .| ||..||.||         | . || ..    .  .|.|   .|   ..|..|     |  .|             |.  .  ||     |  . . 
tkperfvctqgple.......ntcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdki.thrvlkvvvk

LRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRnlKVRGPIVVHDDRGLGPSGVFVASDYCIDQAQ-AGKVDVMQAVYTLRQDRAALVESRAEYQYI
  |.  ...|   . | .||.| |  .   ||  ..  | . |.. |   |.| .| ..  .  |   .   | .| ..   ||.|||  |.  ..| | 
atgqesklnhyqwaswpdhgmpdscdtalrllsavk..kdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvya

HRLVLGYLDGKD
 | || .|  | 
lrcvleflyskg

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 305-394 2.2e-09 31.2 In-house 237-319 (440) alignment
Range on Protein: 305-394
Range on HMM: 237-319/440.0
RFIVTQAPLSgfeSgrvgTQVAFWSMVYQYQAPVVIMLIEPQPHRCTRYWPVPDGNLRSGPFEVRHHGFDKHRGFLVSSLSLTLRGKTHR
 || || ||    |    | . || .|..|.   .||| . . . |. ||||    .  ||| | |.| ..     | .| |  . . | 
afiatqmpld...s....tvldfwrlvhdyristiimlnqlndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevhe

0049260 (Phosphotyrosine protein) phosphatases II 322-487 3.5e-15 51.5 In-house 20-143 (152) alignment
Range on Protein: 322-487
Range on HMM: 20-143/152.0
GTQVAFWSMVYQYQAPVVIMLIEPQPH---RCTRYWpvpdgnlrsgpfevrhhgfdkhrgflvsslsltlrgkthrfqHICLSGWNEHGLPRSSKSVIAL
 |   || |...... ...|| |...     | .|.                                          ...   |  || | .|  .. |
ntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDhgvpdlsqlllfl

LRYLRN--LKVRGPIVVHDDRGLGPSGVFVASDYCIdqaqaGKVDVMQAVYTLRQDRAALVESRAEYQYIH
|. ..   |.  ||..||   |.| .|..|| ....      .|.. .||  .|. |   |..   .....
llfieklaldkggpvlVHCsaGvgRtgtlvaaylml.....lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 322-488 3e-08 28.1 In-house 15-197 (198) alignment
Range on Protein: 322-488
Range on HMM: 15-197/198.0
GTQVAFWSMVYQYQAPVVIMLIEPQPHRC---TRYWPVPD-GNLRSGPFEVRHHGFDKHRGFLVSSLSLT----LRGKTHRFQHICLSGWNEHGLPRSSK
 |   || ||..  .  ..|. . |  .      |||. . |  . | . |  .    .  . ...| ||        |    |  .. |.|.  |  . 
etladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnval

SV---IALLRYLR--NLKVRGPIVVHDDRGLGPSGVFVASDYCIDQ---AQAGKVDVMQAVYTLRQDRAALVESRAEYQYIHR
 |   .|     .  . .   |..||   | | .||||| |  .     ...  ||...    ||| |  .. |   |..|..
fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 322-488 3.3e-08 27.9 In-house 16-198 (199) alignment
Range on Protein: 322-488
Range on HMM: 16-198/199.0
GTQVAFWSMVYQYQAPVVIMLIEPQPHRC---TRYWPVPD-GNLRSGPFEVRHHGFDKHRGFLVSSLSLT----LRGKTHRFQHICLSGWNEHGLPRSSK
 |   || ||..  .  ..|. . |  .      |||. . |  . | . |  .    .  . ...| ||        |    |  .. |.|.  |  . 
etmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnval

SV---IALLRYLR--NLKVRGPIVVHDDRGLGPSGVFVASDYCIDQ---AQAGKVDVMQAVYTLRQDRAALVESRAEYQYIHR
 |   .|     .  . .   |..||   | | .||||| |  .     ...  ||...    ||| |  .. |   |..|..
fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 325-478 9.6e-11 36.2 In-house 42-205 (255) alignment
Range on Protein: 325-478
Range on HMM: 42-205/255.0
VAFWSMVYQYQAPVVIMLIEPQ---PHRCTRYWPVP-DGNLRSGPFEVRHHGfdKHRGFLVSSLSLTL----RGKTHRFQHICLSGWNEHGLPRSSKSVI
 .|. .. | .. ||.|| . .     .| .|.|.  |. |.    .|           ..  | .|.    . |||  .|    || |.  |. .. . 
dkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

ALLRYLRNLKvrgPIVVHDDRGLGPSGVFVASDY--C-----IDQAQAGKVDVMQAVYTLRQDRAALVE
 .|.  |. |   ..||| . | | |  ||  ..        .|.......| .. .  ||. |.. ..
nilkvvrdsk...svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraih

subfamily_hpo-7_pd Subfamily hpo-7 325-477 3.1e-09 31.1 In-house 48-210 (263) alignment
Range on Protein: 325-477
Range on HMM: 48-210/263.0
VAFWSMVYQYQAPVVIMLIE---PQPHRCTRYWPVP-DGNLRSGPFEVRHHGFDKhrGFLVSSLSLTL----RGKTHRFQHICLSGWNEHGLPRSSKSVI
 .|.... | .. ||.|| .    .  .| .|.|.  |. ..    .|      .    |. .| |.     . ||| ..|    || |.  |. .....
dkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelareil

ALLRYLRNLKvrgPIVVHDDRGLGPSGVFVASDY--C-----IDQAQAGKVDVMQAVYTLRQDRAALV
 .|.  ||.|   ..|||   | | |  |.  .         .|.......| .. .  ||. |.. .
nilkvarnsk...slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkrai

0048076 (Phosphotyrosine protein) phosphatases II 380-491 9.7e-11 37.0 In-house 32-140 (145) alignment
Range on Protein: 380-491
Range on HMM: 32-140/145.0
LVSSLSLTLRGKTHRFQHICLSGWNEHGLPRSSKSVIALLRYLRNLKVRG-PIVVHDDRGLGPSGVFVASDYCIDqaqaGKVDVMQAVYTLRQDRAALVE
.| .|. .|.. ..   ...  .|  || | ... ....|......  .| |..||   |.| .|..|| . ..      .|.. .|.  .|. |   |.
tvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll....lgvsleealelvrsqrpgavp

SRAEYQYIHRLVL
.   ........|
npgqlrflyefel

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 393-496 4.8e-11 36.7 In-house 278-387 (392) alignment
Range on Protein: 393-496
Range on HMM: 278-387/392.0
HRFQHICLSGWNEHGLPRS--SKSVIALLRYLR---NLKVRGPIVVHDDRGLGPSGVFVASDYCIDQA-QAGKVDVMQAVYTLRQDRAALVESRAEYQYI
|      . ||  ||  .   ..|.. |.| ..   | |    |.||   | | .||| ..  || |  .   ||..|.|  || ||   |..  || ..
htvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqteeeyafv

HRLVLGYLDG
. ..  ||  
ydvireylht

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 394-503 9.9e-07 22.6 In-house 191-299 (310) alignment
Range on Protein: 394-503
Range on HMM: 191-299/310.0
RFQHICLSGWNEHGLPRSsKSVIALLRYLRNLKvRGPIVVHDDRGLGPSGVFVASDYCIDQAQAG-KVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLG
| . |    | . |.|   |      | | ...  || |||   | .  .| || .. ||... | |||. . .  |...||  ...  .| .|.|. . 
rvslikwpnwpdrgvpde.kchtvpqrllaqvr.hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvrii

YLDGKDQKGAA
.  |....   
fargetevaek

PTPc_DSPc_SM00012 397-491 2.9e-18 61.4 In-house 4-104 (105) alignment
Range on Protein: 397-491
Range on HMM: 4-104/105.0
HICLSGWNEHGLPRSSKSVIALLRYLRNLKV----RGPIVVHDDRGLGPSGVFVASDYCIDQAQAG--KVDVMQAVYTLRQDRAALVESRAEYQYIHRLV
|.  .|| .||.|..|.|.. |||.... |     ..|.|||.  | | .|.||| |....| ...  .||. | |  ||. |. .|.. ..|....| .
hyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyral

L
|
l

0048179 (Phosphotyrosine protein) phosphatases II 397-488 1.2e-09 33.6 In-house 51-139 (144) alignment
Range on Protein: 397-488
Range on HMM: 51-139/144.0
HICLSGWNEHGLPRSSKSVIALLRYLRNL-KVRGPIVVHDDRGLGPSGVFVASDYCIdqaqAGKVDVMQAVYTLRQDRAALVESRAEYQYIHR
...  .|  || | ... ....|...... .  ||..||   |.| .|..|| . ..      .... .|.. .|. |   |...  ......
qylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk....klglsleealalvrsrrpgavpnpgqlrfLle

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 397-494 2.4e-08 27.7 In-house 93-194 (440) alignment
Range on Protein: 397-494
Range on HMM: 93-194/440.0
HICLSGWNEHGLPRSSKSVIALLRYLRNLK---VRGPIVVHDDRGLGPSGVFVASDYCIDQAQ-AGKVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLG
.    || ..|.|. .  |. ... . . .     ||..||   | | .|| .| |  . .|. . ..|..  . ..|..|  .|..  .| ..|  || 
qyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavle

YL
 |
gl

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 400-497 3.9e-07 23.8 In-house 188-288 (302) alignment
Range on Protein: 400-497
Range on HMM: 188-288/302.0
LSGWNEHGLPRSSKSVIALLRYL--RNLKVRGPIVVHDDRGLGPSGVFVASDYCIDQAQAGK-VDVMQAVYTLRQDRAALVESRAEYQYIHRLVLGYLDG
|. |...  | .  ..|.    .  .. |.  ..|.   .| |  |.|..    ... |.|| . . . | ..|..|.. |.|   |  ... .| |.  
ltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk

K
|
k

subfamily_CG42327_pd Subfamily CG42327 428-492 9.5e-11 35.9 In-house 247-313 (319) alignment
Range on Protein: 428-492
Range on HMM: 247-313/319.0
RGPIVVHDDRGLGPSGVFVASDYCIDQAQAG--KVDVMQAVYTLRQDRAALVESRAEYQYIHRLVLG
.||.|||   | | .|. .|||  | . .     ||. | |. .|.|||  | ..  |..|.. .  
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlse