Gene MbrePTP-Un-4 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP058_AA protein Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 874-1155 1.7e-48 160.6 In-house 13-288 (319) alignment 
Range on Protein: 874-1155
Range on HMM: 13-288/319.0
VASFEADYQHVTAEVMHLAHASRLEEVYMRLRQEDEDLgyARQTVKAARANPAKNRYSDILPYDASRVPLKQI-GAAEGDYINANYMPNIGH-RPYIAAQ
|  |.| ||...       . ..||  . |. .   .|  | ||      |  |||. .||..| ..| |... |    ||||| ..    .   |||||
vpdfpayyqqlsnksdfdddltklevefrracklgvnl..adqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaq

GPLPHTEDDFWRMVYGEHSPLVIMLCsinPRKCSPYFPQDpgASKTFENFTVTCQSLVDAQVYERRRLMVVPRSNVRGVKYeplVTeHIWMKSWPDHGTP
|||. | .|||||..  ..  ...|      ||| |.|..  . .. |.| |  .|. ... |  | . .   .. ....    .|    .. |||.| |
GPldntladfWrmiweyncstivllt...kdkcsqywplk..ivikeerfkvkvdsveetaeyvvrdielsedgkekdirk...it.qfhflGwpdvGvp

EVESFLRCM-QAVRR--DFEEPSGRVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALK
.  | | .. . ||   . |.    .||||||||||.|..|..|.| | . . . .||  .| .||. |  .||   ||.||| || 
dypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
0050432 (Phosphotyrosine protein) phosphatases II 878-1155 1.6e-76 252.9 In-house 25-296 (308) alignment 
Range on Protein: 878-1155
Range on HMM: 25-296/308.0
EADYQHVTAEVMHLAHASRLEEVYMRLRQEDEdlgYARQTVKAARANPAKNRYSDILPYDASRVPLkqigAAEGDYINANYMPNI---GHRPYIAAQGPL
.  ....   ....   ..||| ...|..  .   .   .| .  .|  ||||.|||||| ||| |      . |||||.|..       | .||.||||
klsvldllkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgPl

PHTEDDFWRMVYGEHSPLVIMLCSINP---RKCSPYFPQDPG-ASKTFENFTVTCQSLVDAQVYERRRLMVVPRSnvrgvKYEPLVTEHIWMKSWPDHGT
|.| .||||||. .......||...      || .|.| ..|  |.....||||. |    . | .| |.... .     . | ..  |.....|||||.
pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg.....dgesrtvthfhytnWpdhgv

PE-VESFLRCMQAVRRDFeePSGRVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALK
|. .|..|. ...||. .  |.| .||||||||||.||||| |.| . .  .. .||  .| .||..|  |||| .||.|.|.|| 
Ppspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyrall
0039614 (Phosphotyrosine protein) phosphatases II 880-1154 3.2e-71 235.5 In-house 17-285 (297) alignment 
Range on Protein: 880-1154
Range on HMM: 17-285/297.0
DYQHVTAEVMHLAHASRLEEVYMRLRQEDEDlgyarQTVKAARANPAKNRYSDILPYDASRVPLKQIGA--AEGDYINANYMPNIG--HRPYIAAQGPLP
.....   ....   ..|.. ...| .  .|     ... .  .|  ||||.|||||| ||| || ..    . |||||.|..      | .||.|||||
svldlllllekansktllllefeellslkpd.....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlp

HTEDDFWRMVYGEHSPLVIMLCSINPR--KCSPYFPQDPGaskTFENFTVTCQSLVDAQVYERRRLMVVPrsnvrgvKYEPLVTEHIWMKSWPDHGTPE-
.| .||||||. .... ..||.. ...  || .|.|.. |   |...||||. .    . | .| | |..       . |..   |..  .|||||.|. 
etvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkvehldgytvrtlevtn.......ngesrtvthfqytgwpdhgvpps

VESFLRCMQAVRRDFEE--PSGRVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEAL
.|..|. ...||. ..|  ..|.|.|||||||||.||||| ... . .  .. .||. .| .||..|. .||| |||.|.|.||
lellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydal
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 884-1155 3.7e-39 129.2 In-house 12-274 (287) alignment 
Range on Protein: 884-1155
Range on HMM: 12-274/287.0
VTAEVMHLAHASrlEEVYMRLRQEDEDLGyarqtvkaaranPAKNRYSDILPYDASRVPLKQIGAAEGDYINANYMPNIG-HRPYIAAQGPLPHTEDDFW
| .||  | . |  | . . ... .|                 ||||.|.||.| .|| | . |    |||||||..    .  .||||||.. |  |||
vdkevdalkeds..esstatfkaaeelaa............vkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfw

RMVYGEHSPLVIML---CSINPRKCSPYFPQDpGASKTFENFTVTCQSL--VDAQvYERRRLMVVPRsNVRgvkyEPLVTEHIWMKSWPDHGTPEV-ESF
|.|. ..|  ||..         ||  |.|.          ..|.  .    . . |  | | ..   . |    |  | . . . ||||.. .    ..
ravletrsasvitmtreveearlkcykywPer.evPmrvGGysvvlldydikePe.ygvralrlidl.etr....earvvkqldllswPdkvlaPtavgl

LRCMQAV------RRDFEEpSGRVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALK
.| .  |      .|| .|  | .|||...|.||||...|  .| .   |   .|| |||..||..|. .||.. |....|||| 
irfvldvkqhielardase.vGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 885-1156 1.9e-58 193.1 In-house 17-288 (298) alignment 
Range on Protein: 885-1156
Range on HMM: 17-288/298.0
TAEVMHLAHASRLEEVYMRLRQEDEDLGYARQTVKAARANPAKNRYSDILPYDASRVPLKQ-IGAAEGDYINANYMPNIG-HRPYIAAQGPLPHTEDDFW
.|.|..  . ....... ||..  ...  . ..|  ...|  ||||.||...| ||| |..  .  |.||||| .. .   . ..||.|.||..|  |||
laavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFW

RMVYGEHSPLVIMLCSINPR---KCSPYFPQDpgASKTFENFTVTCQSLVDAQVYERRRLMVVPRSNVrgvkyEPLVTEHIWMKSWPDHGTPEV-ESFLR
|||  |..  ..|| ...     |.. |.|..   ..|....||. .|  .   .. |.|.|  ...      .     .. . ||||.|.||. .| | 
rmvteedigtiVmltnleeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkkee.....kerevrqlhftsWpdkgvpenatsvld

CMQAVRRdFEEPSG--RVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKN
 .. ||.  .. .|   |.|.||||||||||||| | . . .   ...||  ||  |||.|  .||| .|| |||||  .
llrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavle
0051299 (Phosphotyrosine protein) phosphatases II 887-1155 2.6e-75 248.9 In-house 15-283 (288) alignment 
Range on Protein: 887-1155
Range on HMM: 15-283/288.0
EVMHLAHASRLEEVYMRLRQEDEDlgyARQTVKAARANPAKNRYSDILPYDASRVPLKQIGA-AEGDYINANYMPN-IGHRPYIAAQGPLPHTEDDFWRM
. ... . ..|.| . .|..  .|     ... .  .|  ||||||||||| ||| |. ..   ..|||||.|..     | .||.|||||.| .|||||
lkllangltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrm

VYGEHSPLVIMLCSINP---RKCSPYFPQdpGASKTFENFTVTCQSLVDAQVYERRRLMVVPRSNVRgVKYEPLVTEHIWMKSWPDHGTPE-VESFLRCM
|. .......||...     .|| .|.|.  | |.|....|||. | .  . |  | |.|.. . ..  . |..   |.....|||||.|. .|..|. .
vweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlld.gdgesrtvthfhytnwpdhgvpdspellldfl

QAVRRDFEEPSGRVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALK
..||. .. ..| |||||||||||.||||| |.| . .  .. .||  .| .||..|  |||| .||.|.|||| 
rlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeall
subfamily_PTPRD_pd Subfamily PTPRD 887-1156 2.1e-68 226.4 In-house 15-279 (564) alignment 
Range on Protein: 887-1156
Range on HMM: 15-279/564.0
EVMHLAHASRLEEVYMRLRQEdEDlgyARQTVKAARANPAKNRYSDILPYDASRVPLKQIGAA-EGDYINANYMPNI-GHRPYIAAQGPLPHTEDDFWRM
. ..  .  ..|| | ..... .     . .. .. || |||||..|..||.||| |... .  . |||||...     .. |||.||||..| .|||||
aklkansdlkfeeeykkieeg.qq...ftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRm

VYGEHSPLVIMLCSIN---PRKCSPYFPQDpGaSKTFENFTVTCQSLVDAQVYERRRLMVvPRSNVRGVkyepLVTEHIWMKSWPDHGTPEV-ESFLRCM
|. ..|  ..|| ...     ||. |.|.. | ..|....||| .. .. . || | . .  ... . .       ..    |||||| ||  .|.|. .
vweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfkl.kkkksses....reVrqFhFtsWPdhgvpesatslLdli

QAVRRDFEEPSGRVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKN
. ||.  |. .| .||||||||||.||||. |.. . | . . .|.  .| .|||.| .|||| .||.||.||. .
rkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaile
subfamily_PTPN23_pd Subfamily PTPN23 887-1154 5.5e-56 184.5 In-house 7-276 (288) alignment 
Range on Protein: 887-1154
Range on HMM: 7-276/288.0
EVMHLAHASRLEEVYMRLRQEDEDLgYARQTVKAARANPAKNRYSDILPYDASRVPLKqigAAEGDYINANYMPNIGH--RPYIAAQGPLPHTEDDFWRM
..  |   . |....  |.|...      ... .|. .. |||. |||||| .|| |.     . ||||| .. ..     ..||.|.||. |  |||.|
qrkmldgktaldkkfkeleqkqdke.arkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlm

VYGEHSPLVIMLCSIN---PRKCSPYFPQDPGASKTFENFTVTCQSLVDAQVYERRRLMVVPRsNVRGVKyeplVTEHIWMKSWPDHGTPE-VESFLRCM
|| ..|....|| | .     |.. |.|.| |....|....||..|  ... . .| | .  . ... ||       |. ..|||..| |.  |..|. .
vyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletl.dadavk....svshlqltsWpelGvPasPetllqfl

QAVRRDFEEPSGR----VVVHCSAGVGRSGTFIAFDMLADAIADGHSM-DVDAVVLQLRKHRRIMVQTASQYQFIYEAL
..|.  .|.   .    .||||||||||.|.|      . ..  |. . |.  || .||. || |||. .|..| ||| 
devesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav
0045450 (Phosphotyrosine protein) phosphatases II 888-1155 1.5e-71 237.0 In-house 20-301 (307) alignment 
Range on Protein: 888-1155
Range on HMM: 20-301/307.0
VMHLAHASRLEEVYMRLRQEDEDLgYARQTVKAARANPAKNRYSDILPYDASRVPLKQIGA--AEGDYINANYMPNI---------GHRPYIAAQGPLPH
...| . ..|.. . .|...  .| .   .. .  .|  ||||.|||||| .|| |. ..    ..|||||.|.              | .||.|||||.
lllldfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

TEDDFWRMVYGEHSPLVIMLCSIN---PRKCSPYFPQDpGASKTFENFTVTCQSLVDAQVYERRRLMVVPRsnvrGVKYEPLVTEHIWMKSWPDHGTPE-
| .|||||.. ... ...||..      .|| .|.|.. | ..|..|||||. |    . | .|.| | .     . . |..   |.....|||||.|. 
tvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdl....dgtgesrtvthfhytgwpdhgvpps

VESFLRCMQAVRRDFEE--PSGRVVVHCSAGVGRSGTFIAFDMLADAIADGHS---MDVDAVVLQLRKHRRIMVQTASQYQFIYEALK
.|..|. ...||. .||  ..|.|.|||||||||.||||| ... . . ...    .|.. .| .||..|  .||. .||.|.||||.
feelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 888-1156 2.7e-54 179.4 In-house 15-281 (305) alignment 
Range on Protein: 888-1156
Range on HMM: 15-281/305.0
VMHLAHASRLEEVYMRLRQEdEDlgyaRQTVKAARANPAKNRYSDILPYDASRVPLKQIGAAE-GDYINANYMPNIG-HRPYIAAQGPLPHTEDDFWRMV
 ..  ... ||. |  | .| |.       |.   || ||||...| ..| .|. |..    .  |||||.|.     .  ||.|||||..| .||||..
earvysdkgleaqykslyee.ee....sidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrli

YGEHSPLVIMLC---SINPRKCSPYFPQDPGASKTFENFTVTCQSLVDAQVYERRRLMVVPRSNvrgvKYEPLVTEHIWMKSWPDHGTPEV-ESFLRCMQ
. |.   ..||.     .  ||  |.|.  . .| |..|.|. .|   |. |  |.| .  ...    . |  .  .  . .||||| |.   |.|. ..
veekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede....dkesrtvlqyqltdWPdhGvpqfatsllslik

AVRRDFEEPSG-RVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKN
 |..| ..  |  ..|||||||||.|.||| |.  . .    ..||  |. |||..|  ||||  ||.|...||..
rvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdalde
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 888-1156 7.7e-54 177.9 In-house 16-281 (319) alignment 
Range on Protein: 888-1156
Range on HMM: 16-281/319.0
VMHLAHASRLEEVYMRLRQEDEDlgyaRQTVKAARANPAKNRYSDILPYDASRVPLKQIG-AAEGDYINANYMPNIGHR-PYIAAQGPLPHTEDDFWRMV
 .. .    ||. .. |.. ..|      .      |  ||||..||.|| .|| |...    . |||||...    .|  .||.|.|| .| .||||||
alastgetllekefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmv

YGEHSPLVIMLCSINPR---KCSPYFPQDpgASKTFENFTVTCQSLVDAQVYERRRLMVVPRSNvrgvKYEPLVTEHIWMKSWPDHGTPEV-ESFLRCMQ
. |.|  |.||. .. .   |.. |.|.     ... ...|| ..    . |. |.|.. ..|.    . |     |   ..||||. ||   | |  ..
Weeessivvmltklveklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklklnkkss....evetRevkhfqyteWpdhdvPekatslldllk

AVRRDFEE-PSGRVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKN
 .|.  |.  || .|||||||||| ||||. |.  . .     .||  .| .||  | ||||. .||.|||||| .
rirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealle
subfamily_PTPRG_pd Subfamily PTPRG 890-1156 9.9e-54 177.5 In-house 14-285 (563) alignment 
Range on Protein: 890-1156
Range on HMM: 14-285/563.0
HLAHASRLEEVYMRLRQEDEDLGYARQtVKAARANPAKNRYSDILPYDASRVPLKQIGAAEG--DYINANYMPNIG-HRPYIAAQGPLPHTEDDFWRMVY
|     ...| .  | .|  .     .    .. |  ||||..|..|| ||| |...   ..  |||||||.     .. .||.||||..| ||||||..
hadgdigfseefealqsetiskdldae.hsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiW

GEHSPLVIMLCS---INPRKCSPYFPQdpGASKTFENFTVTCQSLVDAQVYERRRLMVVPRSNVRGVK--YEPLVtEHIWMKSWPDHGTPEVESF-LRCM
 ... ...|.      . |||  |.|.    |.|.....|| ..     .|  |.|..  .   .. .  .| ||  .  . .|||||.|| . . |  .
eqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklv.rqyhytkWPdhgvPehslpvLifv

QAVRRDFEEPSGRVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKN
.   .  ..  | .||||||||||.||.|..| |   | . ....|  .. ..| .|  .|||  ||.|...|| .
kkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalle
subfamily_PTPRN_pd Subfamily PTPRN 890-1154 4.6e-37 122.3 In-house 24-288 (297) alignment 
Range on Protein: 890-1154
Range on HMM: 24-288/297.0
HLAHASRLEEVYMRLRQEDEDLgYArQTVKAARANPAKNRYSDILPYDASRVPLKQIGAA-EGDYINANYMPNIGHR--PYIAAQGPLPHTEDDFWRMVY
|| . .|||. .  | . . .   . ..|  |  |  |||....|||| ||| ||.  .| . |||||  . .   |   |||.||||..|  |||.||.
hlknkdrlekewealcayeaep.st.kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvw

GEHSPLVIMLCSINP---RKCSPYFPQDpGaSKTFENFTVTcqsLVDAQVYERRRLMV-VPRSNVRGVKYEpLVTEHIwMKSWPDHGTPE-VESFLRCMQ
 . . ....|....    ..|. |.|.. | |.... . |    ||   ..    |.      |..  .    ||      |||..|.|    |.|   .
eqGvvvivnltrleeegvkqckrywpde.G.sevyhiyevh...lvsehiwcddylvrsfylknlqtsetr.tvtqfh.flswpeegvPasaksllefrr

AVRRDFEEPSGRVVVHCSAGVGRSGTFIAFDMLADAIADG-HSMDVDAVVLQLRKHRRIMVQTASQYQFIYEAL
 | . .   |  .|||||.|.||.|..|. |.. . .. | . .|. | .  ||  |  .|.| .|..|.. |.
kvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 891-1157 1.2e-35 117.7 In-house 11-292 (301) alignment 
Range on Protein: 891-1157
Range on HMM: 11-292/301.0
LAHASRLEEVYMRLRQEDEDlgyaRQTVKAARANPAKNRYSDILPYDASRVPLKQI---GAAEGDYINANYMPNIGH-RPYIAAQGPLPHTEDDFWRMVY
 .|. ..|| | .|......    . ||.   .| | ||. .| .||  |. ||.      .. .||||.|. .. . . .||||||. .|  ||||...
akhsnkfeeqykelkegedk....sctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliw

GEHSPLVIMLCSINPR---KCSPYFPQDPGASKTFENFTVTCQSLVDAQVYERRRLMVV--PRSN----VRGVKY----EPLVTEHIWMKSWPDHGT-PE
 |.   ..|..  . .   ||  |.|.    |..| .|||| ..      .  |.| |.    ||     | .|     ..     . . .||..|  .|
qekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvre

VESFLRCMQA-VRRDFEEPSGRVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKNP
    |. ..  . |      | ||||||..|.|||.... ..  .        ||  |.  .|. .  .|.|  || .||....  
prtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 892-1154 1.7e-42 140.3 In-house 17-279 (290) alignment 
Range on Protein: 892-1154
Range on HMM: 17-279/290.0
AHASRLEEVYMRLRQEDEDlgyARQTVKAARANPAKNRYSDILPYDASRVPLKQIGAAEG---DYINANYMPN-IGHRPYIAAQGPLPHTEDDFWRMVYG
   .. .. ...| . ...      ||. .  |  .||...|..||  |..|..|.  .    .|||| |. .   .. |||.|||...|  |||.... 
kgnegfrnqfkmldsgese...htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwq

EHSPLVIMLCSIN---PRKCSPYFPQDpgASKTFENFTVTCQSLVDAQVYERRRLMVVpRSNVRgvKYEPLVTeHIWMKSWPDHG-TPEVESFLRCMQAV
|... ..||..|.     ||  |.|.    .|....|... ..    . | .|.| |   .|    ...  || .  ...|...|  .. .. |  .. .
ekvtiivmltniieegkvkCqqYWpds..dtkaygefsikllneetlneyierklevk.nknsa..gakqsvt.qyqitnwdstgkvtnpqtillvieem

RR-DFEEPSGRVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEAL
 .  . .  . .|||||..||||..|.| ..  .       .|| .|. ..|  .  .|||. |||.|.. .
yktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqiv
0047943 (Phosphotyrosine protein) phosphatases II 893-1155 1.2e-71 236.7 In-house 10-269 (273) alignment 
Range on Protein: 893-1155
Range on HMM: 10-269/273.0
HASRLEEVYMRLRQEDEdlgYARQTVKAARANPAKNRYSDILPYDASRVPLkqiGAAEGDYINANYMPN-IGHRPYIAAQGPLPHTEDDFWRMVYGEHSP
. ..|.| . .|..  .   .   .| .  .|  ||||.|||||| ||| |   |  . |||||.|..     | .||.|||||.| .||||||. ....
gltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvr

LVIMLCSINPR---KCSPYFPQDPGA-SKTFENFTVTCQSLVDAQVYERRRLMVVPRSnvrgvKYEPLVTEHIWMKSWPDHGTP-EVESFLRCMQAVRRD
...||...  .   || .|.|.. |  |.|...||||. |    . |  | |.... .       |...  |.....|||||.|  .||.|.....||. 
viVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg.....tgesrtvthfhytgwpdhgvppslesllefielvrka

FEE--PSGRVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALK
.|.   .| |||||||||||.||||| |.| | .  .. .||. .| .||..|  |||| .||.|.|||| 
lealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall
subfamily_PTPRB_pd Subfamily PTPRB 893-1156 5.6e-64 211.0 In-house 23-283 (293) alignment 
Range on Protein: 893-1156
Range on HMM: 23-283/293.0
HASRLEEVYMRLRQEDEDLgyaRQTVKAARANPAKNRYSDILPYDASRVPLKQIG-AAEGDYINANYMPNI-GHRPYIAAQGPLPHTEDDFWRMVYGEHS
   |. | | .|.. ..|     ...  . .| |||||..|||||.||| |...   .. |||||||.|.   .| .||.|||||.| |||||||. ..|
sdlrfseeyeelkavgkdq...avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekks

PLVIMLCSINP---RKCSPYFPQDPGASkTFENFTVTCQSLVDAQVYERRRLMVVPrsnvrgvKYEPLVTEHIWMKSWPDHGTPEV-ESFLRCMQAVRRD
  ..||  .      ||  |.|.|  .  .. . .|| ..  . . .  | |..         . |   ...   .|||||| ||  ...|. ...||. 
siivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiek.......ekeerkvrqyhftsWpdhgvPektktlldfvrtvrea

F--EEPSGRVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKN
   .. .. .||||||||||.||||| |.| .|| .   .|. ..| .||..| ..||| .|| ||.... .
iektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvld
0040438 (Phosphotyrosine protein) phosphatases II 894-1156 1e-72 240.4 In-house 17-274 (317) alignment 
Range on Protein: 894-1156
Range on HMM: 17-274/317.0
ASRLEEVYMRLRQEDEDlgyaRQTVKAARANPAKNRYSDILPYDASRVPLKQIGA-AEGDYINANYMPNIG-HRPYIAAQGPLPHTEDDFWRMVYGEHSP
. .|.| ...|.. . |      .| .  .|. ||||.||||||.||| |. .|   . |||||.|..     | .||.|||||.| .||||||. ... 
ftalleefedllslkld....tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvt

LVIMLCSINPR---KCSPYFPQdpGASKTFENFTVTCQSLVDAQVYERRRLMVVPRsnvrgVKYEPLVTEHIWMKSWPDHGTP-EVESFLRCMQAVRRDF
...||..  ..   || .|.|.  | ..|...||||..| .  . .. |.|.|..       . |..   |.....|||||.|   ...|. ..|||. .
vivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedl.....gdsesrtvthfhytgWpdhgvppspdllldfleavreal

EEPSGRVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKN
|.|.| |.|||||||||.||||| ... . .  .. .||. .| .||..|. .||| .||.|.|.|| .
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalle
subfamily_PTPN6_pd Subfamily PTPN6 894-1155 2.9e-58 192.3 In-house 25-294 (306) alignment 
Range on Protein: 894-1155
Range on HMM: 25-294/306.0
ASRLEEVYMRLRQEDEDLGYARQTVKAaRANPAKNRYSDILPYDASRVPLKQIGAAEGDYINANYMP---NIGHRPYIAAQGPLPHTEDDFWRMVYGEHS
 . .|| . .|.||..   . |.  .    |  ||||  |||.| .|| ||. . .. |||||||.    .  .. |||.|| |..|  ||||||. |.|
kagfeeefeelqqeeakkllsrkegak.penkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqens

PLVIMLCSINPR---KCSPYFPQDPGASKtFENFTVTCQSLVDAQVYERRRLMVVPRSNVRGVKYeplvTEHIWMKSWPDHGTPEVES-FLRCMQAVRRD
 ...|.   . |   ||..|.|.    .. . . .||. |  ... |. |.|.|  ... .  ..      .   |||||||.|.  . .|  .. |.| 
rvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeere....vfqyhfksWPdhgvpkdpgavLdfledvnrk

FEEPS----GRVVVHCSAGVGRSGTFIAFDMLADAIADG---HSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALK
 || .    | .|||||||.|| ||||  |.| . |        .|.  .| ..|..|  .|||..||.|.|.|.|
qeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
0043336 (Phosphotyrosine protein) phosphatases II 895-1154 5.6e-69 228.0 In-house 20-273 (278) alignment 
Range on Protein: 895-1154
Range on HMM: 20-273/278.0
SRLEEVYMRLRQEDEdlgyARQTVKAARANPAKNRYSDILPYDASRVPLKQIGAAE-GDYINANYMPNIG-HRPYIAAQGPLPHTEDDFWRMVYGEHSPL
..|.. . .|.. .       ... .  .|  ||||.|||||| ||| |. .|  .  |||||.|..     | .||.|||||.|..||||||. .... 
tllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

VIMLCSINPR---KCSPYFPqdpGASKTFENFTVTCQSLVDAQVYERRRLMVVPrsnvrGVKYEPLVTEHIWMKSWPDHGTP-EVESFLRCMQAVRRDFE
..||..   .   || .|.|   | |.|...||||...    . | .| | |..       . |..   |.. ..|||||.|  ....|. ..|||. .|
ivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtn.....lgdgesrtvthyhylgwpdhgvpeslsllldflkavreale

EPSGRVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEAL
 ..| |.|||||||||.||||| ..| . . ... .|.. .| .||..|  .||| |||.|.||||
dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 895-1158 1.5e-59 196.6 In-house 20-280 (318) alignment 
Range on Protein: 895-1158
Range on HMM: 20-280/318.0
SRLEEVYMRLRQEDEDLGYARQtvkAARANPAKNRYSDILPYDASRVPLKQI-GAAEGDYINANYMPN-IGHRPYIAAQGPLPHTEDDFWRMVYGEHSPL
  |.| | || ...|     .       .| ||||| .||.|| .|| |... |  . |||||||..    .. |||||.|||.| .||||||.  .| .
lllseeyerlsrseetvtslks...lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsav

VIMLCSINP---RKCSPYFPQDpgASKTFENFTVTCQSLVDAQVYERRRLMVVpRsnvRGVKYEPLVTEHiWMKSWPDHGTPEV-ESFLRCMQAVRR-DF
..||  ..    .|.  |.|..   |..... .|. .. |. . |  |.. |  |   .... .  |  .  . ||||.|.||   |.|  .. |.. . 
ivmltqeeergkakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvt.r...teeeesrqvrqy.hytsWpdegvpesgaslldlvrqvskaqq

EEPSGRVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKNPL
..  | .|||||||||| |.||| |.| . |..   .||  .| |||..| .|||| .||.|||..|.. |
ksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleal
subfamily_PTPN9_pd Subfamily PTPN9 895-1154 3.8e-48 159.0 In-house 16-286 (297) alignment 
Range on Protein: 895-1154
Range on HMM: 16-286/297.0
SRLEEVYMRLRQEDEDlGYARQtvKAARANPAKNRYSDILPYDASRVPLKQIG-AAEGDYINANYMPNI-GHRPYIAAQGPLPHTEDDFWRMVYGEHSPL
. | . |. .|.|    | . .     |||  ||||.|.| || .|| |...    . ||||||..     .. .||.||||..| .||||||. ..   
rGlskeyaeirnepve.Gtfla..sklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlv

VIMLCSIN---PRKCSPYFPQDPGASKTFENFTVTCQSLVDAQVYERRRLMVvprSNVRGVKYEplVTEHIWMKSWPDHGTPEV-ESFLRCMQAVRRD--
..|   .     .||. |.|.. ..|. | ...|.  . .  . |. | | .   .||.  .       |  . ||||.|.|.  .|.|  ...||.   
ivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvlei...knvkteesr..kvthfqflsWPdyGvPssaaslldvlekvrekqa

-----------FEEPSGRVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEAL
           ..     .|||||||.||.||||..|.  . . .   .||  .| .||. |  ..||  ||.| | |.
lavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylav
subfamily_PTPN1_pd Subfamily PTPN1 895-1154 3.1e-47 155.7 In-house 6-267 (290) alignment 
Range on Protein: 895-1154
Range on HMM: 6-267/290.0
SRLEEVYMRLRQEDEDLGYarqTVKAARANPAKNRYSDILPYDASRVPLKQigaAEGDYINANYMP-NIGHRPYIAAQGPLPHTEDDFWRMVYGEHSPLV
 . .|.|. .|.| .|.     ..    .| ..||| |. ||| ||. |..   |. |||||. .  .  .| || .|||||.| | ||.||. ..|  |
rlykeiyldirkeasdfpt...reaklpenrnlnryrdvspydhsrikler...adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskav

IMLCSI---NPRKCSPYFPQDPG-ASKTFE--NFTVTCQSLVDAQVYERRRLMVVPrsnVRGVkyEPLVTEHIWMKSWPDHGTPEV-ESFLRCMQAVRRD
.||  .   .  ||  |.||.    . ..|  ...|.  |  . . | .| | .     ..    |  .  |    .||| | ||   .||. .. ||. 
vmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelen...lktq..etreilhfhyttwpdfgvpespaaflkflfkvres

--FEEPSGRVVVHCSAGVGRSGTFIAFDMLA---DAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEAL
  . .  | .|.|||||.||||||.  | .    ..  |  |.|.  |.|.|||.|  ..||| | .| | |.
GslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_ptpA1_pd Subfamily ptpA1 899-1111 8.7e-27 88.9 In-house 22-249 (418) alignment 
Range on Protein: 899-1111
Range on HMM: 22-249/418.0
EVYMRLRQEDEDLGYARQTVKAARANPAKNRYSDILPYDASRVPLKQIGAAEG-DYINANYMPNIGHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLC
..   .|  .| .| .  .    . | .||||..||| . .|| ||.|   || |||||||.     . .|..||||| |  ||||||. ..  ...|| 
kikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmls

--SINPR-KCSPYFPQDPGASK------TFENFTVTCQSLVDAQVYERRrlMVVPRsNVR-GVKYEPLVTEHIWMKSWPDHGTPEVES-FLRCMQAV--R
  | | | ||  |.|.. |  .        | |      ||.      |   .. | |.|  .. |     .   . ||||  |.    | . ....  |
resencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdper..eiitr.nirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnr

RDFEEPSG----RVVVHCSAGVGRSGTFIAF
..   ||      ..|||||||||.||| . 
qnqiipssdrnvpiivhcsagvgrtgtfcta
DSPc_SM00195 900-1155 2.3e-70 232.3 In-house 5-259 (263) alignment 
Range on Protein: 900-1155
Range on HMM: 5-259/263.0
VYMRLRQEDEDLgyaRQTVKAARANPAKNRYSDILPYDASRVPLKQIGA-AEGDYINANYMPNI-GHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLC
 . .|......    . | ..  .| .||||..||||| .|| ||..    . |||||||.      . |||.|||||.| .||||||. |......||.
efekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

SINP---RKCSPYFPQDPGASKTFENFTVTCQSLVDAQ-VYERRRLMVVPRSNvrgvkYEPLVTEHIWMKSWPDHGTP-EVESFLRCMQAVRRDFEEPSG
. .    .||. |.|.. | ..||....|....    .  ...| | .    .      |.  ......|.|||||.| . .|.|. ..||. . .. ||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.....eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssg

RVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALK
 .||||||||||.|||.. |.. . ..... .|....| .|||.|  ||||  ||.|||||. 
pivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeail
PTPc_SM00194 900-1155 2.3e-70 232.3 In-house 5-259 (263) alignment 
Range on Protein: 900-1155
Range on HMM: 5-259/263.0
VYMRLRQEDEDLgyaRQTVKAARANPAKNRYSDILPYDASRVPLKQIGA-AEGDYINANYMPNI-GHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLC
 . .|......    . | ..  .| .||||..||||| .|| ||..    . |||||||.      . |||.|||||.| .||||||. |......||.
efekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

SINP---RKCSPYFPQDPGASKTFENFTVTCQSLVDAQ-VYERRRLMVVPRSNvrgvkYEPLVTEHIWMKSWPDHGTP-EVESFLRCMQAVRRDFEEPSG
. .    .||. |.|.. | ..||....|....    .  ...| | .    .      |.  ......|.|||||.| . .|.|. ..||. . .. ||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.....eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssg

RVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALK
 .||||||||||.|||.. |.. . ..... .|....| .|||.|  ||||  ||.|||||. 
pivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeail
0046845 (Phosphotyrosine protein) phosphatases II 901-1155 3e-74 245.3 In-house 6-271 (284) alignment 
Range on Protein: 901-1155
Range on HMM: 6-271/284.0
YMRLRQEDEDlGYARQTVKAARANPAKNRYSDILPYDASRVPLKQIGA--AEGDYINANYMPN------IGHRPYIAAQGPLPHTEDDFWRMVYGEHSPL
...|..   .  .   .| .. .|  ||||.|||||| ||| || ..    ..|||||.|..       . .. .||.|||||.| .||||||. .....
feellsltvk.lllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrv

VIMLCSINPR---KCSPYFPQDpGASKTFENFTVTCQSLVDAQVYERRRLMVVPRsnvrGVKYEPLVTEHIWMKSWPDHGTPE-VESFLRCMQAVRRDFE
..||...  .   ||..|.|.. | ..|...||||. |    . | .|.|....     |.. |..   |....||||||.|. .|..|. ...||. .|
IVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnl....gytgesrtvthfhytswpdhgvppspedlleflrlvrelle

--EPSGRVVVHCSAGVGRSGTFIAFDMLADAIADGH---SMDVDAVVLQLRKHRRIMVQTASQYQFIYEALK
  ...| .||||||||||.||||| |.| . .  ..    .||  .| .||..|  |||| .||.|.|||| 
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyeall
subfamily_PTPN12_pd Subfamily PTPN12 903-1156 5.6e-58 191.1 In-house 16-275 (290) alignment 
Range on Protein: 903-1156
Range on HMM: 16-275/290.0
RLRQEDEDLGYA---RQTVKAARANPAKNRYSDILPYDASRVPLKQIGAAE-GDYINANYMPNI-GHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLC
.|... | .      ....  .  | .|||| |||||| ||| |..|   |  ||||||.. .  |.  |||||||||.| ||||||..  .  .|.|.|
klkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaC

SI---NPRKCSPYFPQDPGASKTFENFTVTCQSLVDAQ-VYERRRLMVVPRSNVRGVKyeplvteHIWMKSWPDHGTPE-VESFLRCMQAVRRDFEEPSG
 .   .  ||  |.|.  . . .|..|.||...    .  .  | | |  ... | |.        .  ..|||||.|. ..| |. ...||.  |. . 
revelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvy.......qfhYtaWPDhgvPssaksllelielvrelqeseda

RVVVHCSAGVGRSGTFIAFDMLADAIADGHS---MDVDAVVLQLRKHRRIMVQTASQYQFIYEALKN
 .|||||||||| || || |.  ... ...    .||  .||.|||.|  .|||  ||...|.|. .
PlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae
subfamily_PTPRK_pd Subfamily PTPRK 905-1169 6.5e-53 174.6 In-house 25-287 (314) alignment 
Range on Protein: 905-1169
Range on HMM: 25-287/314.0
RQEDEDLGYARQTVKAaRANPAKNRYSDILPYDASRVPLKQIGAA-EGDYINANYMPNIgHR--PYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSINP
..| | |    .. |    | .|||. |||.|| ||| |..|    . |||||...    .|   .|..||||..|  ||||.|| |..  ..||  .  
keeyeslfegwdaakk.denreknrsgdilaydrsrvflitidgdpssdyinaalidsy.krpaafivtqgPlqetvkdfWrlvydencasivmltelve

RK---CSPYFPQDpgaSKTFENFTVTCQSLVDAQVYERRrLMVVPRsNVRGVKYEPLVtEHIWMKSWPDHGTPEV-ESFLRCMQAVRRDFEEPSGRVVVH
     |. |.|.|   ....... |.. .    . .  | .. | .   ||..   .|  ..   .||||..|   ...|. .. |    ||  ||.|||
vgrvkClkyWPed...tevygdikvelvetellaelvvr.ifrvek.largqeeirev.rqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvh

CSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKNpLCVCVCVCVCVC
|||| ||.||||| |.. | |   . .||  .| .||...  ||.|  ||.|||... .  |.|   .. |.
CsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile.aclcgetaipvs
0036941 (Phosphotyrosine protein) phosphatases II 911-1155 6.1e-73 241.0 In-house 26-274 (297) alignment 
Range on Protein: 911-1155
Range on HMM: 26-274/297.0
LGYARQTVKAARANPAKNRYSDILPYDASRVPLkqiGAAEGDYINANYMPNIG-HRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSINP---RKCSP
| .   .| .  .|  ||||.|||||| .|| |   .  . |||||.|..  .  | .||.|||||.| .||||||. .... ..||..  .    || .
lllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaq

YFPQDPGASKTFENFTVTCQSLVD--AQVYERRRLMVVPRSNVrgvkyEPLVTEHIWMKSWPDHGTPE-VESFLRCMQAVRRDFEE--PSGRVVVHCSAG
|.| . | |.|...||||..|      . | .| | |..  |      |...  |.....|||||.|| ..|.|. ...||.  ..  ..|.|.||||||
ywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.....esrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaG

VGRSGTFIAFDMLADAIA---DGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALK
||||||||| |.. . .      . .|.  .|..||..|  .||| .||.|.|||| 
vgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeall
subfamily_Ptp69D_pd Subfamily Ptp69D 913-1156 9.6e-54 177.6 In-house 36-284 (307) alignment 
Range on Protein: 913-1156
Range on HMM: 36-284/307.0
YARQTVKAA-RANPAKNRYSDILPYDASRVPLKQI-GAAEGDYINANYMPNI-GHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSIN--PR-KCSP
  ..|. ..   |  |||| || ..|  || ||.| | .. |||||...     .. .||||.|.  | .|||||.   .. |..||  ..  .| ||. 
idkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcak

YFPQDpgASKTFENFTVTCQSLVDAQVYERRRLMVVPRS-NVRGVKYEPLVTEHIWmKSWPDHGTPEV-ESFLRCMQAVRRDFEEPSGRVVVHCSAGVGR
|.|..    . ...  |.. |   .. | .| | |     ..  |. .  |. . . ..|.|   ||| .. |. .. ||   .   . .||||||||||
YWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhy.tgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgr

SGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKN
||.|.|.|.| . .   ...|. ..| .||..| ..||   ||.|.| || .
sgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralld
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 913-1159 7.4e-51 167.9 In-house 33-278 (315) alignment 
Range on Protein: 913-1159
Range on HMM: 33-278/315.0
YARQTVKAARANPAKNRYSDILPYDASRVPLKQIG-AAEGDYINANYMPNIGH-RPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSI--NPR-KCSPY
  ||.|   . |  |||| .|||.| .|| |. |    . ||||| |.. . . . |||.||||. . |||||||..|.   ..|.     . . ||  |
iyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqy

FPQDPGASKTFENFTVTCQSLVDAQVYERRRLmVVPRSNvrgvkYEPLVTEHIwMKSWPDHGTPE-VESFLRCMQAVRRDFEEPSGRVVVHCSAGVGRSG
.|.  . |  | .. |.  ||        |.| |. .|.         || .  .. |||.|... . |.|. ...|. | ..    ..|||||||||.|
wPdrkadsvefGsikvellsleadtdgvarkl.vtrkse.....esrtvtqfq.ftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtG

TFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKNPLC
 .|. |   . |....|.||  .| .||..|  .|||  .| |||.|... | 
vvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPN14_pd Subfamily PTPN14 913-1154 8e-47 154.7 In-house 38-292 (300) alignment 
Range on Protein: 913-1154
Range on HMM: 38-292/300.0
YARQTVKAARANPAKNRYSDILPYDASRVPLKQIGAAEGDYINANYMP---NIGHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSI---NPRKCSP
 |  .. .   |  |||. |.|||. .|| |.    .. .||||  .       .| ||.|||||..|  |||.||. ..  |..|| ..      |.  
dallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfk

YFPQD--PGASKTFENFTVTCQSLVDAQVYERRRLMV--VPRSNVRGVKyeplvteHIWMKSWPDHGTPE-VE---SFLRCMQAVRRDFEEPS------G
|||..     . .|..| || .   |.. .  . | .  .| .. | |        |.  . ||||| || |.   |.|. .|.||| ... .       
yfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvw.......hlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskP

RVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEAL
 |.|||||||||.|  |  |.|  ..  ....|.. |. .||. | ..||| .||.|.|..|
PvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 914-1155 5.7e-47 155.6 In-house 15-252 (284) alignment 
Range on Protein: 914-1155
Range on HMM: 15-252/284.0
ARQTVKAARANPAKNRYSDILPYDASRVPLKQI-GAAEGDYINANYMPNIGH-RPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCsinPRKCSPYFPQD
. ||      |  |||. .||..| ..| |... |    ||||| ..    .   |||.||||. | .|||||..  ..  ...|      ||| |.|..
tdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt...kdkcsqywplk

pgASKTFENFTVTCQSLVDAQVYERRRLMVVPRSNVRGVKYeplVTeHIWMKSWPDHGTPEVESFLRCM-QAVRR--DFEEPSGRVVVHCSAGVGRSGTF
  . .. |.| |  .|. ... |  | . .   .. ....    ..    .. |||.| |.  | | .. . ||   . |.    .||||||||||.|..
..ivikeerfkvkvdsveeseeyvvrdielsedgkekdirk...ir.qfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvy

IAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALK
|..|.| | . . . .||  .| .||. |  .||   ||.||| || 
ivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 914-1158 2.8e-39 129.6 In-house 35-236 (392) alignment 
Range on Protein: 914-1158
Range on HMM: 35-236/392.0
ARQTVKAARANPAKNRYSDILPYDASRVPLKQIG-AAEGDYINANYMPNIGH-RPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSINPRKcspyfpqd
 .|||     |  |||| .|||||..|| |. |   .. ||.|| |.|..   . |||.||| . . |||||||. |.   ..|.  ..           
ypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd........

pgasktfenftvtcqslvdaqvyerrrlmvvprsnvRGVKYEPlVTEHiWMKSWPDHGTPE-VESFLRCMQAVRRDFEEPSGRVVVHCSAGVGRSGTFIA
                                    .| ..   |. .  .  |||.. |. . |.|. .. |. || . .  ...||||||||.|  |.
....................................kgddart.vaqf.hftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvis

FDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKNPL
 | .       . .||  .| ..|..|  ||||  || ||| |. . |
idsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 914-972 5.4e-08 26.9 In-house 38-95 (95) alignment 
Range on Protein: 914-972
Range on HMM: 38-95/95.0
ARQTVKAARANPAKNRYSDILPYDASRVPLKQigAAEGDYINANYMPNIGH-RPYIAAQG
|  || .. ||  |||. .|.||||.|| |      . ||||| ..        ||||||
apytvgsseanipknrflnifpydatrvvltt..krdsdyinacfvdgyarkncyiaaqg
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 915-1156 3.3e-60 198.6 In-house 30-274 (281) alignment 
Range on Protein: 915-1156
Range on HMM: 30-274/281.0
RQTVKAAR--ANPAKNRYSDILPYDASRVPLKQIGA-AEGDYINANYMPN-IGHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCS---INPRKCSPY
..| .|..  .|  |||||.|  |||.|| ...  .  . ||||||..|   |.. |||.|||.|.. ..||.||. ..  ...|.      .  ||  |
dntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrY

FPqDPGASKTFENFTVTCQSLVDAQVYERRRLMVvPRSNVrgvkyEPLVTEHIWMKSWPDHGTPEV-ESFLRCMQAVRRDFEEPS-GRVVVHCSAGVGRS
.| |. .. .. ..||. ..  . . | .|....  |..      |.   |..  ..||||| |.  . .|   ..|..  |. .   .|.||||||||.
WP.ddnselkygdvtvkstaeeekatyierkfkl.eresg.....etreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrt

GTFIAFDMLADAIADG-HSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKN
||.||.| |..|...  ...||.||| .|||.| .||||  ||.|.| |...
GtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavld
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 915-1154 1.9e-58 192.8 In-house 37-275 (288) alignment 
Range on Protein: 915-1154
Range on HMM: 37-275/288.0
RQTVKA-ARANPAKNRYSDILPYDASRVPLKQI-GAAEGDYINANYMPNI-GHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSI---NPRKCSPYF
... ..    |  |||| .|||||  || ||.    |. |||||.|. .  ... |||.||||..| .|||..|| ...  ..|| ..   . .||  |.
ksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYW

PQDpGASKTFENFTVTCQSLVDAQVYERRRLMVVprsnvrgVKYEPLVTEHIWMKSWPDHGTPEV-ESFLRCMQAVRRDFEEPSGRVVVHCSAGVGRSGT
|.. .  | . ..||| ..  . . .  |.|...        | . | . .   ..||||| ||  . .|  .. |    .. .|...|||||||||.||
Pda.dkpknyGsvtvtlveskeledfvlrkllle.......kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgt

FIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEAL
||| |.| ||.     .|| ..| .|||.|  .||| .||.||||.|
FialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 915-1159 1.6e-52 173.3 In-house 34-277 (515) alignment 
Range on Protein: 915-1159
Range on HMM: 34-277/515.0
RQTVKAARANPAKNRYSDILPYDASRVPLKQIG-AAEGDYINANYMPNIGH-RPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSIN---PRKCSPYFP
 |||     |  |||| .||||| .|| |. |  . . ||.|| |.| .   . |||.|||.. . |||||.|. |.   ..|.   .     ||. |.|
pqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWP

QDPGASKTFENFTVTCQSLVDAQVYERRRLMVVPRSNVRGvkyeplVTEHIwMKSWPDHGTPE-VESFLRCMQAVRRDFEEPSGRVVVHCSAGVGRSGTF
. || |  | .. |   ||       .|.| |.  ...|       || .  .. |||.|.|.   |.|. ...|. | .. .  ...|||||||| | .
dkpgdsvkfGsikvelvsleactggikrkltvlkgddsrt......vtqfh.fteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvv

IAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKNPLC
|. |     .......||  .| ..|..|  .|||  || |||.|... | 
isidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 915-1158 1.4e-49 163.9 In-house 42-284 (297) alignment 
Range on Protein: 915-1158
Range on HMM: 42-284/297.0
RQTVKAARANPAKNRYSDILPYDASRVPLKQIGAA-EGDYINANYMPNIGHRpYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSINP--RKCSPYFPQD
 |||   . |  |.||..||||| ||| |. ..   . ||.|| ... . || .|. | | . | .|||.||. |.   ..||   |   .||  |....
pqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhr.littqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdk

pgASKTFENFTVTCQSLVDAQVYERRRLMVvPRSNVrgvKYEPLVTEHIWMkSWPDHGTPE---VESFLRCMQAVRRDFEEPSG-RVVVHCSAGVGRSGT
  ...|| . .|. .|. . . . .| | |  ...    | . .|  . .. .|||.  ..   ..|.|  .. || ||.. .   ..|||.||||| | 
..gvttfGdvsvvllsvsereGfikrelev.tkgka...karrvvkqyqfv.eWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgv

FIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKNPL
... |     . . ...|.  .| .||..|  .|||  ||.|.|.|. . |
lltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 915-1156 1.2e-40 134.3 In-house 38-276 (287) alignment 
Range on Protein: 915-1156
Range on HMM: 38-276/287.0
RQTVKAARANPAKNRYSDILPYDASRVPLKqigAAEGDYINANYMPNIG-HRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSI---NPRKCSPYFPQ
  |.. |  |  |||...||..|  ||.||     . ||||| ..     .. .|.|..|. .|  .||...  .. . ..|||     . ..|  |.|.
evthniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpe

DPGasKTFENFTVTCQSLVDAQVYERRRLMVVpRSNVRGvkyEPLVTEHIWMKSWPDHG-TPEVE-SFLRCMQAVRRDFEEPSGRVVVHCSAGVGRSGTF
.     .. .....  .    . |  |.| |  ..|  |   ...  .   . .|...|  .| . ..|   . .. .  .  . .|||||..||||..|
eks..vvlGeyniellneevnagyierklevk.nknkag...dkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamf

IAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKN
.| ..  .       .||  |. . |  .  .|||..||.||.... .
caaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivle
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 915-1156 5.8e-30 99.3 In-house 34-269 (288) alignment 
Range on Protein: 915-1156
Range on HMM: 34-269/288.0
RQTVKAARANPAKNRYSDILPYDASRVPLKqigAAEGDYINANYMPNIGH-RPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSIN---PRKCSPYFPQ
 .....  |||...|| ..   |..|| |.        ||.|| ..   . |  | || ||  | . .|.|.  .    ..||| .     .|   ||| 
idiidsfianptrdryenlprcditrvkls...ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPs

DPGASKTFENFtvtCQSlVDAQVYERRRLMVVPRSNVRGVKYEPLVTEHIWMKSWPDHGTPE-VESFLRCMQAVrRDFEEPsgrVVVHCSAGVGRSGTFI
  | .  .  .   |.  |  .  .  .|..|   ..  .  |. .  .. .. |.|.| ||   |.|| .. . .....|   .|||.||||||.||.|
klGekarigrl...ctv.vkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.kslqkP...ivvhssaGvGrtgtli

AFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKN
   . ....     . .  .. .||..|.  .||  || ...  ...
lilialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvle
subfamily_PTPRA_pd Subfamily PTPRA 916-1156 1.7e-52 173.3 In-house 48-293 (330) alignment 
Range on Protein: 916-1156
Range on HMM: 48-293/330.0
QTVKAA--RANPAKNRYSDILPYDASRVPLKQI-GAAEGDYINANYMPNIGHR-PYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSINPR---KCSPYF
 |...|    |  |||. .||||| ||| | .. |  | ||||| ..    ..  .||||||. .| .|||||..  .|  ..||  .. |   ||  |.
atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw

PQDpgASKTFENFTVTCQSLVDAQVYERRRLMVVPRSNVRGVKYEPLVTeHIWMKSWPDHGTPE-VESFLRCMQAVRRDFEEPSGRVVVHCSAGVGRSGT
|..   . |. | .|. .  . .. |  | ..|   .. .  | . ||.  . ..|||| | |      |. ...|..  .  .| .||||||||||.||
Pde..GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvr.qfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGt

FIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKN
||..| . . .   . .||  .| .||. |  ||||  ||.|||..|..
fivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 916-1156 5.6e-45 148.9 In-house 40-286 (325) alignment 
Range on Protein: 916-1156
Range on HMM: 40-286/325.0
QTVKAARANPAKNRYSDILPYDASRVPLKQIG-AAEGDYINANYMP-NIGHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSINP--RKCSPYFPQD
..| .  .| ||||. .....| ||| |.  . ... |||||.|.  ...   ..||| ||..| .|.||.|.  ....|..|  ..    .|. |.|..
kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpke

PGASKTFENFTVTCQSLVDAQVYERRRLMVvprsnvRGVKY-EPLVTEHIWMKSWPDHGTPEV----ESFLRCMQAVRRDFEE---PSGRVVVHCSAGVG
 | ||||  . |  ... .   |  |.| |      ..||  | .  .   ..||.| |...      |.|. ..||          |. ..||||||||
mgksktfGglevklrtieeisdyvhrvldv......kqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvG

RSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKN
|.|.||..  ... . .  ..|.  .| .|||.|  ||.|. || .||||| .
rtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealve
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 916-1165 4.3e-43 142.2 In-house 25-274 (283) alignment 
Range on Protein: 916-1165
Range on HMM: 25-274/283.0
QTVKAARANPAKNRYSDILPYDASRVPLKQIGAaegDYINANYMP----NIGHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSIN---PRKCSPYF
 ....|. |. |||. .|.|.|  || ||       ||||| ..|    .   . ||.||.|| .|  |||.||. |.   ..||  .      ||| |.
adiasadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyW

PQDpgASKTFENFTVTCQSLVDAQVYERRRLMVVPRsnvrGVKYEPLVTEHIWMKSWPDHG-TPEVESFLRCMQAVRRDFEEPSGRVVVHCSAGVGRSGT
|..   |. . .|||| .  .  . . .. |..       .   . |.  |  .  | . |  . ..|...  . .    |.. | .|||||.|.||...
Pkr..GsedyGeftvtlrkettsnsfiikelllrvn....ssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtav

FIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEAL-KNPLCVCVCVC
|||     . .     .|| |||  .|..|  .|||  ||....|.  .. ||    . 
fiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqia
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 916-1154 3.1e-39 129.8 In-house 33-273 (307) alignment 
Range on Protein: 916-1154
Range on HMM: 33-273/307.0
QTVKAARANPAKNRYSDILPYDASRVPLKQIGAAeGDYINANYMP-NIGHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSI---NPRKCSPYFPQD
 ||.| .||. ||||.|.   | .|. .|  |.|  ||| |||.   |  . .|.|||||  |  .|| |.  |.   ||||| .      ||  |.| .
vtveafsantdknryqdvkcqdkgrivvkfdgla.sdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywple

PGASKTFEN--FTVTCQSLVDAQVYERRRLMVVPRSNVRGVKYEPLVTeHIWMKSWPDHGTPEVE-SFLRCMQAVRRDFEePsgrVVVHCSAGVGRSGTF
 |  ..| .   |.. . |   ..     |. |   .|   .    .. |.  . |||.|.|... . .  ..||| | . |   |||||||||||||| 
egqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiq.hlqwenwpdrgvpqinltainlleavrydtn.p...vvvhcsaGvGrsGti

IAFDMLADAIADGH-SMDVDAVVLQLRKHRRIMVQTASQYQFIYEAL
.|  .. | . .|   .|.. .| .||..|.  .||  || ...  |
vaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 916-1154 1.2e-32 108.0 In-house 27-266 (285) alignment 
Range on Protein: 916-1154
Range on HMM: 27-266/285.0
QTVKAARANPAKNRYSDILPYDASRVPLKQigaAEGDYINANYM--PNIGHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSIN---PRKCSPYFPQ
 |  |  |||  |||.|.   . .|| ||.    . ||| |..|  |   .  ||..||||| |  |||.|.| |.   |.|||..      ||. |.|.
ctytayeanpdlnryadvrcieetrvvlkn...hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype

DPGASKTFENFTVTCQSLVDAQVYeRRRLMVVPRSNVRGVKYEPLVTEHIWMKSWPDHGTPEVESFLRCMQAVRRDFEEPSGRVVVHCSAGVGRSGTFIA
  |    | .. .|     .  .     |  .   |      |||  .|. .  |||. .||    .  .    .  .     ..|||||||||. ||. 
klgevvkfgkyeitlteckeeaia.gtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvg

FDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEAL
 |  .  | .   ...  .| ..|  |   ||.  |. |.|  |
idyatirimenpniemldivremramrfqavqshmqflflyvvl
subfamily_eak_pd Subfamily eak 916-1154 3.9e-16 53.4 In-house 43-301 (332) alignment 
Range on Protein: 916-1154
Range on HMM: 43-301/332.0
QTVKAARANPAKNRYSDILPYDASRVPLKQIGAAEGDYINANYM--PNIGHRpYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCS---INPRKCSPYFPQ
   ..|| .  .    .|.|||   | |      .  ||||  .  ...|.. || .  .       ||.||. ..|| ...|      .  |   |||.
sisetarleavnrnvvkivpydrylvrltssqlnrlGyinaslaefsevGrk.yiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpd

DPGASKTFENFTVTCQSLVDAQVYERRRLMVVPRSNVRGVKY----------EPLVTEHIW-MKSWPDHGTPEVESF-LRCMQAVRRDFE--EPSGRVVV
.      |  . |.... |  ...| | |..    .   |..           | . . .   |   . |.. .      ..... . .    ||   ..
ktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapii

HCSAGVGRSGTFIAFDMLADAIADG--HSMDVDAVVLQLRKHRRIMVQTASQYQFIYEAL
 .. |  |.|.|.  |.|   | .    .  |. ..|. ...|   | .| |. ||||..
qsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeiv
0045098 (Phosphotyrosine protein) phosphatases II 917-1154 2.7e-68 225.7 In-house 26-268 (278) alignment 
Range on Protein: 917-1154
Range on HMM: 26-268/278.0
TVKAARANPAKNRYSDILPYDASRVPlkqigaaegDYINANYMPNIgHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSINPR---KCSPYFPQdpG
|.   . | .||||.|||||| |||          |||||.|..   .. .||.|||||.| .|||||.. .... ..||..  ..   || .|.|   |
tpalylgnldknRykdilpydhsrVk.........dYINAsyidgy.pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..g

ASKTFENFTVTCQSLVDAQVYERRRLMVVPRSNVRgVKYEPLVTEHIWMKSWPDHGTPEVE---SFLRCMQAVRRDFEE-------------PSGRVVVH
 |.|...||||..|    . |  |.|.|.  .. |   .|..  .|.....|||||.|. .   |||.... .|.  ..             ..|.|.||
gsltygdftvtllseevlddytlrtllvtnltver.edlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVH

CSAGVGRSGTFIAFDMLADAIadGHSMDVDAVVLQLRKHRRI-MVQTASQYQFIYEAL
|||||||.||..| ... . .  .. .|.. .| .||..|.. .||. .||.|.||.|
CsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 917-1155 1.9e-52 172.9 In-house 13-261 (270) alignment 
Range on Protein: 917-1155
Range on HMM: 13-261/270.0
TVKAARANPAKNRYSDILPYDASRVPLKQIGA-AEGDYINANYMP--NIGHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSIN---PRKCSPYFPQ
.. .|  ... ||| ||||  |.|| |...    .  ||||||..  .  .. ||||.|||| |  .||||.. |... ..|.  ..    .||. |.|.
dlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa

DPGASKTFENFTVTCQSL--VDAQVYERRRLMVVPRSNVRGvkyepLVteHIWMKSWPDHGTPEVES-------FLRCMQAVRRDFEEPSG--RVVVHCS
.|. . ..|. ...  .|  . .. | ..|| .  ... |      ||  | |...||||| |. |         |....||||  .| .    ..||||
epkekvkledgkikvlalseekeegyiltrlrleekgeerr.....lv..HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcs

AGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALK
|||||.||.|| |.   ..   ...|| |.. .|||.|  .||.  ||.|.|.|. 
aGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 917-1156 6.4e-36 118.7 In-house 41-277 (439) alignment 
Range on Protein: 917-1156
Range on HMM: 41-277/439.0
TVKAARANPAKNRYSDILPYDASRVPLKQI-GAAEGDYINANYMPN-IGHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSI-NPRKcspYFPQDpg
.. |   . .|||| |. ..| .|| |..| |     ||||||.      . |||.|||  .| |||||.|. ...  ..||. . .  |   |.| |  
slaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk...ywpsd..

ASKTFENFTVTCQSLVDAQVYERRRLMVVPRSNvRGVKYEPLVTEHiwMKSWPDHGTPEVES----FLRCMQAVrRDfEEPSGRVVVHCSAGVGRSGTFI
|   . . .| ..  ..   |  | . |. . . .. |   ..  |    .|||.  |   |    |||....   | .|  | |||||||||||.|| |
aevcygdiavrvdrnielpnyvirgfkvfnerd.ttekertvlqfh..yiawpdknvpaqashvldflrainsa.nd.keeygpvvvhcsagvGrtGtii

AFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKN
|.|.  . .     .|.. .|  |||.|. |||.  || |||.|. .
aldialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 917-1151 2.5e-31 103.4 In-house 45-283 (310) alignment 
Range on Protein: 917-1151
Range on HMM: 45-283/310.0
TVKAARANPAKNRYSDILPYDASRVPLKQIGAAEGDYINANYMP-NIGHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSINP---RKCSPYFPQdP
| .| . .  ||||||..  |.||| ||   .  .||| |||.  |     .| .|||| ||  |||||.. | .  ...|| .      ||  |.|   
tyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps.l

GASKTFENFTVTCQSLVdAQVYERRRLMV--VPRsNV----RGVKYEPLVTEHIWMKSWPDHGTPEVEsflrCMQAVRRDF-EEPSGRVVVHCSAGVGRS
| ..|.    ||  |   .. .|   | |  ||  ||    .  . . |  . |    ||| | |.      |    .| . .   | .|||||||..| 
gvtetygcirvtnlses.seefeicnlavtfvpd.nvpvdeqpanlkelrvslikwpnwpdrgvpdek....chtvpqrllaqvrhgpcvvhcsagkdrl

GTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIY
.. .| ..  | .  |. .|.. |. .|.|.| | .||  || .| 
yvvvalklkidkldrglkvdaeevktellksraiciqtelqyliid
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 917-1156 2e-30 100.6 In-house 42-285 (305) alignment 
Range on Protein: 917-1156
Range on HMM: 42-285/305.0
TVKAARaNPAKNRYSDILPYDASRVPLkqIGAAEGDYINANYMPNI-GHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSIN---PRKCSPYFPQDP
. | |. .  |||| |.   |  || |   |.   .|| |||.      . .| .| || .|  ||| | . ..   ..||| .     .||. ||. . 
afkeaq.eagknrykdvgcldnnrvkl..egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskd

GASKTFEN----FTVTCQSLVDAQVYERRRLMVVPR-SNVRGVKYEPLVTEHIWMKSWPDHGTPEVESFL-RCMQAVRrdfeEPSGRVVVHCSAGVGRSG
.   .||.     .| ..| |  .  .  .  |      . |   . . . |     ||| | |  .  .   ..  |       | .|||||||.||.|
kdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar....pskgpivvhcsagigrtg

TFIAFDMLADAIADGHSMD-VDAVVLQLRKHRRIMVQTASQYQFIYEALKN
. . .. . | .  |. ..  | .. ..|. |   .||  || |... . |
svvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 919-1154 9.5e-35 114.6 In-house 32-265 (281) alignment 
Range on Protein: 919-1154
Range on HMM: 32-265/281.0
KAARANPAKNRYSDILPYDASRVPLKQ--IGAAEGDYINANYMP-NIGHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCS---INPRKCSPYFPQDP
     |  ||||..|   | ||| ||         ||| |||.   . .| || .|||   |  |||||.. | .  ..|||     |  ||. |||.. 
fnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

GASKTFENFTVTCQslvDAQVYerrRLMVVPRSNVRGVKYEPLVTEHIWmKSWPDHGTPEVESflrCMQAVRRDFEEPSGRVVVHCSAGVGRSGTFIAFD
 .   |....|. .   |. |    . .|  | |.       |.|  .| | |||   ||       |  . |     |   |.|||||||||||..| .
hcclqfdklsvsye...dstvn...kslvttrlnlsyegetrlithwlw.kewpdwqvpesse...vmlkilrkirarstppvihcsagvgrsgtlmave

MLADAIADGHSM-DVDAVVLQLRKH-RRIMVQTASQYQFIYEAL
.  ..|    .. |.  .| .||   |   |||  || .|.. |
ialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 919-1156 1.5e-30 100.9 In-house 50-287 (305) alignment 
Range on Protein: 919-1156
Range on HMM: 50-287/305.0
KAARANPAKNRYSDILPYDASRVPLKQIGaaEGDYINANYM--PNIGHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCS---INPRKCSPYFPQDPG
..|  . .||||.|.   | | | |..      ||| |||.  | | .. .|.||||| .| |.|| ||  ..   ..|||    .   ||. |.|   |
qsadiaitknryqdvpcqdqsavkldkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqg

ASKTFENFTVtCQSLVDAQVYERRRLMVVPRSNVRGVKYEPLVTEHIWMKSWPDHGTPEVE-SFLRCMQAVRRDfEEPsgrVVVHCSAGVGRSGTFIAFD
  ... .  |  . .  ..  ||   . .   |.     . .   |.    ||| | | .  . |  . |.|   . |   .|||||||.||.|| .| .
eklelksgiv.venvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgs.kvp...ivvhcsagigrtgtivaie

MLADAIADGHSM-DVDAVVLQLRKHRRIMVQTASQYQFIYEALKN
 . . ||. ..   .  .|  || .|   .|.  || ||.  . |
yilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_egg_pd Subfamily egg 919-1153 8.5e-25 82.1 In-house 35-265 (307) alignment 
Range on Protein: 919-1153
Range on HMM: 35-265/307.0
KAARANPAKNRYSDILPYDASRVPLK-QIGAAEGDYINANYMPNI-GHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCS-INPRKCSPYFPQDPGAS
 |.  |  | |   .   | ||| |. . |   .|.| ||..        .| || ||  | |||||||. |. . ..|| |  .. .|  |.|. .  |
aasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesds

KTF--ENFTVTCQSLVDAQvyerRRLMVVPRSNVRGVKYEPLVTEHiWMKSWPDHGtpEVESFLRCMQAVRrdfeEPSGRVVVHCSAGVGRSGTFIAFDM
  .   .. ...  . ..       |. | . .. | . | .  || |   .   .  .| | || .. .|    . |  |||..  || ...|..| ..
lvtvpGslrienlkvdska....dplfrvtklklvGgddeerfleh.wqgdvnnss..dvysplrvlrklr....nlskpvvvqdilGvskaatlvaiei

LADAIADGHS--MDVDAVVLQLRKHRRIMVQTASQYQFIYEA
    .  |      |   |  ||..||. |... .| |.|  
allsllrGpitkslvlravvflrlrrrlsvesvllylfvyrl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 919-1154 4.3e-19 63.0 In-house 46-281 (302) alignment 
Range on Protein: 919-1154
Range on HMM: 46-281/302.0
KAARANPAKNRYSDILPYDASRVplkQIGAAEGDYINANY--MPNIGhRPYIAAQGPLPHTE---DDFWRMVYGEHSPLVIMLCSINPR--KCSPYFPQD
|| ..|..||.  |.  .|. .|   ...|.. .|.||    .|... |. | || |   .|   ..|||||. |.   | .|   ..     | .||. 
kafkknlkknqsedvpildsnlv...kleaepdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkk

PGASKTFENFTVTCQSlVDAQVYERRRLM--VVPRsnvrGVKyEPLVTEHIWMKSWPDHGTPE-VESFLRCMQAVRRDFEEPSGRVVVHCSAGVGRSGTF
 |. |..... |  .  |. .. |. |..  |.|     |.  . ....   .. |...  |. . .  . .. |    .. . ..|.    |.|| |.|
sgdykeygkmfvNnrk.VekaeeektryviEvlPe....gcs.nsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagaf

IAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEAL
..  .  . . .|.   .  .| ..|. |  .|....|| ..| ||
ltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyial
0040439 (Phosphotyrosine protein) phosphatases II 920-1155 1.8e-65 216.3 In-house 7-243 (249) alignment 
Range on Protein: 920-1155
Range on HMM: 7-243/249.0
AARANPAKNRYSDILPYDASRVPLKQIGA-AEGDYINANYMPNI-GHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSINPR---KCSPYFPQdpGA
   .|. ||||.|||||| ||| |. ..    .|||||.|..     | .||.|||||.| .|||||.. ...  ..||.|  ..   || .|.|.  | 
llpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..gg

SKTFENFTVTCQSLVDAQVYERRRLMVVPRsnvrgVKYEPLVTEHIWMKSWPDHGTP-EVESFLRCMQAVRRDFEE--PSGRVVVHCSAGVGRSGTFIAF
|.....||||. |    . | .| |....       . |..   ||.. .|||||.|  .|..|. ..|||  .||  ..|.|.|||||||||.||||| 
sleygdftvtllsvevkddytvrtleltnl.....ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALK
... . .   . .|.. .| .||..|. .||. .||.|.||||.
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall
subfamily_PTPN13_pd Subfamily PTPN13 920-1154 6.1e-51 168.3 In-house 33-265 (273) alignment 
Range on Protein: 920-1154
Range on HMM: 33-265/273.0
AARANPAKNRYSDILPYDASRVPLKQIGAaegdYINANYMP-NIGHR--PYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSIN---PRKCSPYFPQDPG
  ..| .|||| ..||||..||.|.. |.    ||||...  ..|.    |||.|||||.| .|||.||.  .. ...|. .       ||  |.|.  .
kkkenkdknryrnvlPydetrvklgdegg....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPeskn

ASKTFEN-FTVTCQSLVDAQVYERRRLMVVPrSNVRGVKYeplvTEHIWMKSWPDHGTPEVESFLRCMQAVRRDFEEPSGRVVVHCSAGVGRSGTFIAFD
 . . .| ..|.   ... . .  |.|.|   |. . ..       |. . .|||||.|     |  . |  | ... .| .|||||||.|||||.|. |
kklkvsnrlevellkvqkldgfvvralavkd.sesgesre....vahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitid

MLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEAL
.. . |.  ...||  .| .||. |. .|||  || |.|.|.
vvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 920-1157 1.4e-49 163.5 In-house 5-241 (250) alignment 
Range on Protein: 920-1157
Range on HMM: 5-241/250.0
AARANPAKNRYSDILPYDASRVPLKQIG-AAEGDYINANYMPNI-GHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSIN--PRKCSPYFPQDpgAS
   .|  ||||.||...| ||| |..     | ||||| ..    ... .||.||||..|  ||||||. |.|  ..|| ...   .... |.| .   .
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPve..ka

KTFENFTVTCQSLVDAQVYERRRLMVVPRSNVRGVkyeplVTEHIWMKSWPDHGTPEV-ESFLRCMQAVRRDFEE-PSGRVVVHCSAGVGRSGTFIAFDM
... . ||.  |      |. |.|..  ...   .     .  ..   .||| | ||| .. |  .. |..  ..  .. |.|.|||||||||.||| | 
ekyGdvtvsllskeefadytkrklklskakkader.....ivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaida

LADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKNP
. . .   . .||  |. .|||.|  .|.. .|| |.||.... 
vlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 920-1154 1.3e-24 81.7 In-house 29-255 (267) alignment 
Range on Protein: 920-1154
Range on HMM: 29-255/267.0
AARANPAKNRYSDILPYDASRVPLKQigaAEGDYINANYMPNI-GHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSINPRKCSPYFPQDPGASKTF
 |  | ..||. | |||| .||.|..    | .|||| |.      . .|. |.||  |  ||. ..  .. | ...|  .   .   ..|   | .| .
iaeknqernrlddnlpyddtrvilrt...keeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgqakky

ENFTVTCQSLVDAQVYERRRLMVVPRSNvrGVKYeplVTEhIWMKSWPDHgTpEVESFLRCMQA--VRRDFEEPSGRVVVHCSAGVGRSGTFIAFDMLAD
...||      . . |.   | .  . .    .    ||   . | |    | . . .|. . .   . ..|. .  .||.||.||||||||.  |   .
qdltvehslekeendyqiitlelkfkne..sahn...vtl.yyykkwnin.t.nnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqle

AIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEAL
 .     .|.   ....|. |  .|.|  .| .|.| |
raktegvsdifdflrkirsqriglvdtkeryiyihell
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 920-1079 1.4e-24 81.5 In-house 27-189 (297) alignment 
Range on Protein: 920-1079
Range on HMM: 27-189/297.0
AARANPA--KNRYSDILPYDASRVPLKQiGAAEGDYINANYM--PNIGHR-PYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSINP---RKCSPYFPQD
.|. | .  |||| ||| .| .|| |.. . .| |||||.|.  |.  .   || |||||  | ||||..|. .    ..|.. ..     || ||.|. 
sakrnsslrknryrdilatddtrvkllr.viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

PGASKTFENFTVTCQSLVDAQvYERRRLMVVpRSNVRgvkYEPLVTEHIWMKSWPDHGTP-EVESFLRC
 .  ..  .. |   | .  . ..|  |  . .   |    |  |  |.   |||||| | ..|   | 
vqerlkagdvvveflsstsde.fdrviltel.qliyr...sesrvvrhvqflswpdhGvpsdledlvrf
subfamily_PTPN3_pd Subfamily PTPN3 921-1154 2.9e-51 169.0 In-house 38-271 (280) alignment 
Range on Protein: 921-1154
Range on HMM: 38-271/280.0
ARANPAKNRYSDILPYDASRVPLKQigaAEGDYINANYM----PNIG-HRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSINP---RKCSPYFPQdP
  .| .|||| ||||||| || ||.   .| |||||||.    |  |    |||.||||..|  |||.||. ..| |..|| ..      ||  |.|. .
kpenlsknryrdilpydatrvklke...setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.t

GASKTFENFTVTCQSLVDAQVYERRRLMVVPRSnVRgvkyEPLVTEHIWMKSWPDHGTPEVE-SFLRCMQAVRRDFEEPSGRVVVHCSAGVGRSGTFIAF
. . .. .|.|.|..    . |  | |..  ..  .    |     ..   .||||| |. . .||. .. ||.  .  .  ||||||||.||.| .|..
edeleygefsvkcekedetksyvlrelvlkdke.tk....eerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlill

DMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEAL
..    |   ... . ..| ..|  | ..|||||||.|. ||.
etalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
0049772 (Phosphotyrosine protein) phosphatases II 921-1156 1.1e-39 132.4 In-house 43-278 (314) alignment 
Range on Protein: 921-1156
Range on HMM: 43-278/314.0
ARANPAKNRYSDILPYDaSRVPLKQIGAAEGDYINANYMPNIghRPYIAAQGPLPHTEDDF----------WRMV--YGEHSPLVIM-------------
  .|. |||| ||||.| .|| |.  .    |||||.|. ..  . .||.||||..| .||          ||||  .  ..  . |             
lflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf..lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrL

--------LCSINPRKcspyfpqdpgASKTFENF---TvtcqslvdaqvyerrrlmvvprsNVR--GVKYEPLVTEHIWMkSWPDHGTPEVESFLRCMQA
        |... ..           .  |....                           ..   . ..| |. .....  .||...|  | |......
daAlgKtpllildgng..........neptaadlellk.......................eelydpelferlgikylri.pvpDgsaplledfdeflef

VRRDfeEPSGRVVVHCSAGVGRSGTFIAFDMLADAIadghSMDVDAVVLQLRKHRR-----IMVQTASQYQFIYEALKN
...   .. |.|.|||.||.||.|||.. ..|  .      .... .. ..|. |       ....  ||.||.|||..
ieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 921-1153 1.6e-32 107.6 In-house 5-236 (239) alignment 
Range on Protein: 921-1153
Range on HMM: 5-236/239.0
ARANPAKNRYSDILPYDASRVPLKQIGA-AEGDYINANYMPNIGHR--PYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSI---NPRKCSPYFPQDpgA
 | | |||||..|. || ||| |...      |||||.|. .       |||.|| .  .  |||||.. |.  ...||  .     .||  |.|.   .
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds..t

SKtFENFTVTCQSlvdAQVYERRRLMVVPRSNVrGVKYEPLVTEHiWMKSWPDHGTPEVES-FLRCMQAVRRDFEEPSGRVVVHCSAGVGRSGTFIAFDM
|| . |. || .    ..|.    .  .  |.| |   |  | ..  .  |||.| |.  .  |   . . .|    .   |.||||||||.|.|.  | 
sk.ycnlrvtlrk...tevfadyiirtfvmsqv.gqteeryvyqy.hftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvida

LADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEA
.       ...|.   |  .|. |  ||||. || ||. |
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 921-1153 1.8e-32 107.4 In-house 4-235 (239) alignment 
Range on Protein: 921-1153
Range on HMM: 4-235/239.0
ARANPAKNRYSDILPYDASRVPLKQIGA-AEGDYINANYMPNIGHR--PYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSI---NPRKCSPYFPQDpgA
 | | |||||..|. || ||| |...      |||||.|. .       |||.|| .  .  |||||.. |.  ...||  .     .||  |.|.   .
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds..t

SKtFENFTVTCQSlvdAQVYERRRLMVVPRSNVrGVKYEPLVTEHiWMKSWPDHGTPEVES-FLRCMQAVRRDFEEPSGRVVVHCSAGVGRSGTFIAFDM
|| . |. || .    ..|.    .  .  |.| |   |  | ..  .  |||.| |.  .  |   . . .|    .   |.||||||||.|.|.  | 
sk.ycnlrvtlrk...tevfadyiirtfvmsqv.gqteeryvyqy.hftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvida

LADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEA
.       ...|.   |  .|. |  ||||. || ||. |
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
0042113 (Phosphotyrosine protein) phosphatases II 922-1155 2.5e-65 215.6 In-house 7-240 (245) alignment 
Range on Protein: 922-1155
Range on HMM: 7-240/245.0
RANPAKNRYSDILPYDASRVPLKQIGAAE-GDYINANYM--PNIGHRpYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSINP---RKCSPYFPQdpGAS
 .|. ||||||||||| .|| |. .|  .  |||||.|.  ..| .. .||.|||||.| .|||||.. ...  ..||..  .    || .|.|.  | |
penkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ges

KTFENFTVTCQSLVDAQVYERRRLMVVPRsnvrgVKYEPLVTEHIWMKSWPDHGTPE-VESFLRCMQAVRRDFE-EPSGRVVVHCSAGVGRSGTFIAFDM
.|...||||. |    . | .| |.|..       ..|..   |..  .|||||.|. .|..|.....||.  .  ..|.|.|||||||||.||||| ..
ltygdftvtllseehlddytvrtlevtnl.....gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

LADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALK
... .   . .... .| .||..|. .||| |||.|.||||.
mleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
0037934 (Phosphotyrosine protein) phosphatases II 922-1155 9.3e-61 200.8 In-house 8-239 (243) alignment 
Range on Protein: 922-1155
Range on HMM: 8-239/243.0
RANPAKNRYSDILPYDASRVPLkqigaAEGDYINANYMPNIGHrpYIAAQGPLPHTEDD----FWRMVYGEHSPLVIMLCSIN---PRKCSPYFPqdpgA
 .|  ||||||||||| ||| |       .||||||...  ..  .|| |||||.| .|    ||||.. ...  ..||..       || .|.|     
penlsknrysdilpydhsrvkl.....egsdyinanliyvtpr..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp....g

SKTFENFTVTCQSLVDAQVYERRRLMVVPrsnvRGVKYEPLVTEHIWMKSWPDHGTPE-VESFLRCMQAVRRD--------FEEPSGRVVVHCSAGVGRS
..|...||||. |    . |  | |....     . .....   |..  .|||||.|. .|..|. ...||           . ..|.|.|||||||||.
evtygdftvtllseehlddytvrtlllen....ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GTFIAFDMLADAIadghSMDVDAVVLQLRKHRRI-MVQTASQYQFIYEALK
||.|| ... . .    ..|.. .| .||..|   .||| |||.|.||||.
Gtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 922-1158 3.7e-48 159.1 In-house 47-279 (315) alignment 
Range on Protein: 922-1158
Range on HMM: 47-279/315.0
RANPAKNRYSDILPYDASRVPLKQIG-AAEGDYINANYMPNIG-HRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSI---NPRKCSPYFPQDpgaSK
  |  |||| .|..|| ||| |  .    . ||.|||...    .| |||||||.. . .||||.|. |.   ..|| ..   . ||.  |.| .     
ienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kv

TFENFTVTCQSLVDAQVYERRRLMVVPRSNVRGVKyeplvteHIWMKSWPDHGTPEV-ESFLRCMQAVRRDFEEPSGRVVVHCSAGVGRSGTFIAFDMLA
.. ..||| .|    . |  | | || ..|.| |         . . |||| | |.   ...  .. |..  ..  | .||||||||||.||||..| . 
iyGkitvtrkseevnteytvrtlsvvfgdnirevv.......qlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavl

DAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKNPL
| .   . .||  .. ..|. |. |||.| ||||||.|| . .
dqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_CG7180_pd Subfamily CG7180 922-1156 8.3e-36 118.1 In-house 40-288 (296) alignment 
Range on Protein: 922-1156
Range on HMM: 40-288/296.0
RANPAKNRYSDILPYDASRVPLKQI-GAAEGDYINANYMPNI-GHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSIN-PRK-CSPYFPQDPgaSKT
  |  |||. ...|||  || |... | .. ||||| |.     .. ||  ..|  .| |.|||.|| |..  |..|.     .| .  |.|..    . 
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks..keq

FENFTVTCQSLVDAQVYERRRLMVVPR-----SNVRGVKYEPLVTEHIWMKSWPD-HGTPEV-ESFLRCMQAVRRDFEEP-----SGRVVVHCSAGVGRS
. .. |   .       . | . .. .     .. ..|| |  .  .. .. |.  .  | . ....  .. ||   |.       | |||..| |..||
ygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRs

GTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKN
| ..| |.  . .   . .||   | .||..|. .|..  .|..||. |..
GvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 922-965 6.6e-06 19.7 In-house 45-89 (440) alignment 
Range on Protein: 922-965
Range on HMM: 45-89/440.0
RANPAKNRYSDILPYDASRVPLKQI-GAAEGDYINANYMPNIGHR
  |  |||| .|| || ||| |... |  . ||||| |.  |  |
pnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingiesr
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 923-1155 9.3e-57 187.2 In-house 27-265 (274) alignment 
Range on Protein: 923-1155
Range on HMM: 27-265/274.0
ANPAKNRYSDILPYDASRVPLK-QIGAAE-GDYINANYM--PNIGHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSI---NPRKCSPYFPQDPGA-
 .  |||| .||| . ||| |. . . .|  .||||||.  ..  .. |.|.|||||.| .|||||.| |......||  .   | .||. |||.. .. 
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

-SKTFENFTVTCQSLVDAQVYERRRLMVVPRSNVRGvkyeplvTEHIWMKSWPDHGTPE-VESFLRCMQAVRRDFEE---PSGRVVVHCSAGVGRSGTFI
 |...... .. .. |. . |. |.|..   .. |          |.|  .|||| .|. ....|. .. |... ||   . . ||||||||.|| | ||
iserygdveikvekiverndysvrklvlkylerers.......vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfi

AFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALK
| ..    . . . .||  .| .|| .|  ||||..||..|..|| 
aisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 923-1154 5.8e-44 144.9 In-house 53-279 (290) alignment 
Range on Protein: 923-1154
Range on HMM: 53-279/290.0
ANP--AKNRYSDILPYDASRVPLKQigAAEGDYINANYMPNIgHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSIN---PRKCSPYFPQDPGASKT
.|.   |||| |.   | .|| ||.    .|||. |||.  . . ..| .||.|  |  |.||||  |.   ..||| .      ||..|.|.  |   |
kntefkknrykdvvcndktrvilkd..GydGdyvhanyvkGl.kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

FENFTVTCQSLVDAQVYERRRLMVVprSNVRGVKYEPLvtEHIWMKSWPDHGTPEVE-SFLRCMQAVRRDfeepSGRVVVHCSAGVGRSGTFIAFDMLAD
| ..||.|    | .    .... |   ..   |   |   |. .|||||.  .  . ..|| ....|.     || ||||||||.||.|||.| .. ..
fGeitvlcseeddkdaniikktlsv..rdkdsGkehkl..khlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievglq

AIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEAL
 . ||...|.  .|  ||. |   ||   ||  . |.|
illdGkeldlldlvralrnsrlnsvqvdiqylalveil
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 923-1155 4.3e-16 53.4 In-house 46-276 (303) alignment 
Range on Protein: 923-1155
Range on HMM: 46-276/303.0
ANPAKNRYSDILPYDASRVPLkqigaAEGDYINANYMPNIGHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLC---SINPRKCSPYFPQDPGAsKTFE
 |  |||. |..  | |.| |     ..  || |.|.    ..  | .| ||.||  |||.|.  ..   |..|      .       ||..      ||
knmdknrfvdvicldhskvkl.....sdssyihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf.lkfe

NFTVTCQSLVDAQVYERRRLMVVPRSNVrgvKYEPLVTEHIWmKSWP-----DHGTPEVESFLRCMQAVRRDFEEPSGRVVVhCSAGVGRSGTFIAFDML
. ..    .   .. .   | |.  ||    .|  ..  | . |.||      .|.|..   .  .|.| | . . .  | .   .|.||.|||  |.  
ersirvgefkrvelgdgwvlkvlsvsng...dyksflhvhhy.kawphnsipsdgspkfvkqiwqlqsvlrkysdstptvym.slsgcgragtfalfeta

ADAI-ADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALK
  .. ..  |.|.  .. ..|. |   ||  ||. ..|  | 
hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytlla
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 923-1024 3.2e-11 37.3 In-house 95-194 (244) alignment 
Range on Protein: 923-1024
Range on HMM: 95-194/244.0
ANPAKNRYSDILPYDASRVPLKQiGAAEGDYINANYMPNIGHR-PYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSINPRkcSPYFPQDPGASKTFENF
 |  ||| .  ||.| .|||| . |.    |||| ..  .|    || .| ||  |  |||.|.   |  ....| |..      |.|.        |. 
nnswknregaglpfdfnrvplsk.gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee..deywpdseplewyeedi

TVT
|||
tvt
Y_phosphatase Protein-tyrosine phosphatase 924-1154 8.7e-68 223.6 Pfam-A 1-233 (235) alignment 
Range on Protein: 924-1154
Range on HMM: 1-233/235.0
NPAKNRYSDILPYDASRVPLKQIGAAEGdYINANYMPNI-GHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSINP---RKCSPYFPQDPGASKTFE
|  ||||.|||||| .|| ||. . ..  ||||||. .   .. .||.||||..| .||||||. |.. ...||.| .    .||..|.|.. . |.|..
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

NFTVTCQ-SLV-DAQVYERRRLMVVPRSNVRgvkyEPLVTEHIWMKSWPDHGTP-EVESFLRCMQAVRRDFEEPSGRVVVHCSAGVGRSGTFIAFDMLAD
...|... .   | . |  | | .  . . .    |.  ........|||||.| ...|.|.....|... |. || |||||||||||.|||.| |.| .
dikvelkekekedekeytlrklelkkkkees....ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

AIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEAL
 . .....||  .| .|||.|. |||...||.|.|.|.
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 924-1154 8.7e-68 223.6 In-house 1-233 (235) alignment 
Range on Protein: 924-1154
Range on HMM: 1-233/235.0
NPAKNRYSDILPYDASRVPLKQIGAAEGdYINANYMPNI-GHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSINP---RKCSPYFPQDPGASKTFE
|  ||||.|||||| .|| ||. . ..  ||||||. .   .. .||.||||..| .||||||. |.. ...||.| .    .||..|.|.. . |.|..
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

NFTVTCQ-SLV-DAQVYERRRLMVVPRSNVRgvkyEPLVTEHIWMKSWPDHGTP-EVESFLRCMQAVRRDFEEPSGRVVVHCSAGVGRSGTFIAFDMLAD
...|... .   | . |  | | .  . . .    |.  ........|||||.| ...|.|.....|... |. || |||||||||||.|||.| |.| .
dikvelkekekedekeytlrklelkkkkees....ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

AIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEAL
 . .....||  .| .|||.|. |||...||.|.|.|.
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
0041856 (Phosphotyrosine protein) phosphatases II 924-1154 6.7e-44 145.0 In-house 1-167 (182) alignment 
Range on Protein: 924-1154
Range on HMM: 1-167/182.0
NPAKNRYSDILPYDASRvplkqigaaEGDYINANYMPNIGHR-PYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCsinprkCSPYFPqdpgasktfenft
|  ||||||||||| ||           ||||||..    .   .||.||||..|  ||.||.....  ....|.      . .|.|             
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywp.............

vtcqslvdaqvyerrrlmvvprsnvrgvKYEPLVTEHIWMKSWPDHGTPEVESFLRCMQAVRRdfeePSGRVVVHCSAGVGRSGTFIAFDMLADAiadgh
                            ....    ...  .|||||.|.....|. ...|..    ..|.|.|||||||||.||..| ...        
............................ellerlgiqylylpwpDhgvpdldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....

SMDVDAVVLQLRKHRRIMVQTASQYQFIYEAL
..... .| ..|..|  ||.| .||.|.. ||
gvsleeavklvrsrRpgmvitpnqyfflqlal
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 924-1153 5.7e-37 122.2 In-house 3-234 (237) alignment 
Range on Protein: 924-1153
Range on HMM: 3-234/237.0
NPAKNRYSDILPYDASRVPLKQIGAAeGDYINANYMPNIGHRP--YIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSI---NPRKCSPYFPQDpGASKTF
| .||||..|  || ||| ||  |..  |||||.|. ..   |  ||||||||  . ||||.||. |.  ...||  .   |  ||  |.|.     ...
nkiknrygnivaydhsrvvlkgagsg.sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaay

ENFTVTCQSLVDAQVYERRRLMVVPRSNVRGVKyepLVtEHIWMKSWPDHGTPEVE-SFLRCMQAVRRD--FEEPSGRVVVHCSAGVGRSGTFIAFDMLA
  .||. .   .   |  | |... | ....|.   |.     . ||||.| |.   ..||  . .         ||  ..||||||||.| |.  | . 
gvltvslkkkeefsdytvrslllskrltlkevr...li.hqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml

DAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEA
    . . .|.   |  . . |  ..||  || ||...
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqt
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 924-1019 6.4e-06 19.9 In-house 34-132 (332) alignment 
Range on Protein: 924-1019
Range on HMM: 34-132/332.0
NPAKNRYSDILPYDASRVPLKQIGaAEGDYINANYMPNIGHR-PYIAAQGPL-PHTEDDFWRMVYGEHSPLVIMLCSINPR--KCSPYFPQDPGASKTFE
|   ||   .  .| ||| |      . |. ||...    ..  || || |.  |||  |||||   .  .....  |. .  . .||   | |  |.| 
nmdmnriphlycfdhsrvelapqd.gkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgfeksfl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 925-1156 1.5e-31 104.4 In-house 48-342 (350) alignment 
Range on Protein: 925-1156
Range on HMM: 48-342/350.0
PAKNRYSDILPYDASRVPLK---------QIGAAEGDYINANYMPN------IGHR-PYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCS---INPRKCS
 |||||..||||. ||| ||         .      |||||||.        |     |||.|.||| | |||.....  . .....| |    | .|| 
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

PYFPQDPGAS------KTFENFTVT-CQSLVDAQVYERRR--------LMVV---PRSNVRGVKYEPLVTEHIWMKSWPDHGT-PEVESFLRCMQ-----
 |...            . || . .   ||  |.| .             .       ...    .|.|  .. .| |.| ..  . ||.|. ..     
rYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevkndl

---AVRRDF--EEPSGRVVVHCSAGVGRSGTFIAFDMLAD-----AIADGHSMD----------VDAVVLQLRKHRRIMVQTASQYQFIYEALKN
    . . .  .. |  ..||||||||| ||....|.|            .|            .  .|..||| |  |||.  |. ||||||..
iddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallf
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 925-998 6.9e-12 39.3 In-house 49-140 (349) alignment 
Range on Protein: 925-998
Range on HMM: 49-140/349.0
PAKNRYSDILPYDASRVPLKQI---------------GAAEGDYINANYM--PNIG-HRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCS
 |||||.|||||. ||| ||.                ..   |||||||.  ..|  .. ||| | ||| | |||....  .  .||. | .
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnd
subfamily_CG42327_pd Subfamily CG42327 926-1080 4.9e-15 50.0 In-house 30-186 (319) alignment 
Range on Protein: 926-1080
Range on HMM: 30-186/319.0
AKNRYSDILPYDASRVPLKQIGAAEG-DYINANYM--PNIGHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSINP---RKCSPYFPQDPGAS--KT
 |.|. ...|   .|| |..||  .   |..|.|.  ..  .  ||||| .|  .  ||||.|.   |  .. |...     ..|. |.|   .    ..
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

FENFTVTCQSLVDAQVYERRRLMVvprSNVRGVKYEPLVteHIWMkSWPDHGTPEVESFLRCM
. .. || .     . |    |..    .| . .  .|   | |   |.. . |  |. | .|
yGdilvtlkgrevkdryaistlll...krvdkeesrelt..hywy.kwleaevPaeeaaliam
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 928-1153 8.5e-22 72.2 In-house 47-271 (312) alignment 
Range on Protein: 928-1153
Range on HMM: 47-271/312.0
NRYSDILPYDASRVPLkqiGAAEGDYINANYMpNIGHRPY--IAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSIN---PRKCSPYFPQDPGAsKTFENFT
||| .|  .|  |  |      |  || ||.. .|  .|   ...||||  |   ||...    |  .|.||..      ||. |  .  |    .|.  
nrypniqcwdrgrftl...agdenfyihanfv.kictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgf.vdledhr

VTCQSLVDAQVYERRRLMVVPR---SNVRGVKYEPLVTEHIWmKSWPDHGTPE-VESFLRCMQAVRRDFEePsgrVVVHCSAGVGRSGTFIAFDMLADAI
|  ..  . ..  . .  .  |     |.    |  .  . |  |||||| |. ... || . ||..|   |   |. ||||||||.||..  . .  |.
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqw.aswpdhgmpdscdtalrllsavkkdkk.p...viahcsagvgrtgtlaliesmiaal

ADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEA
      .|  . . ||| |   |..  || .   .
rhprkqnvkdsfvllrkdrarsvrvfpqyvyalrc
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 934-1010 9.2e-06 20.0 In-house 3-71 (130) alignment 
Range on Protein: 934-1010
Range on HMM: 3-71/130.0
LPYDASRVPlkqigaaEGDYINANYMPNIGH-RPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSINPRkcSPYFPQ
|... ||..       . .||||...  .|. . |. .| ||  |  |||.|.   .  ....| |..      |.|.
lefevsrlq.......gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee..deywpd
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 937-1151 1.2e-23 78.7 In-house 31-252 (290) alignment 
Range on Protein: 937-1151
Range on HMM: 31-252/290.0
DASRVPLKQIGAA-EGDYINANYMPNIGHRPYIAAQGPLPHT-------EDDFWRMVYGEHSPLVIMLCSINPR-------KCSPYFPQDPGASKTFENF
 |.||.||. |     ||| ||..        |. | |. ..         .|| |.  |..  |.|||  . .        |. |.|.  | . .|...
eatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgl

TVTCQSLVDAQVYERRRLMVvprsnvRGVKYEPLVTEHIWMKSWPDHGTPEVE-SFLRCMQAVRrdfeEPSGRVVVHCSAGVGRSGTFIAFDMLADAIA-
|| |.| .  .  |.|.|.|      .  . |..  .| ..|.| .  ..| . ..|  .| |.         |.|||  |. || .. | ..    || 
tvkCkskekeddvetRelvv......kfddeeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgyQkiae

DGHSMDVDAVVLQLRKHRRIMVQTASQYQFIY
  .|. . .|. .|||.|  ....| .. |. 
tsgsvkledvlkalrkqralaitsalelafvd
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 944-1148 7.6e-28 92.1 In-house 68-271 (301) alignment 
Range on Protein: 944-1148
Range on HMM: 68-271/301.0
KQIGAAEGDYINANYMPNIGHR-PYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSI---NPRKCSPYFPQDPGASKTFENFTVTC---QSLVDAQVYeR
. |   .   | ||..|  ||   .||.||||. | .||| |.   .   ..||.     . .||. |.|.... .   . |...    ..... ... .
evivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkis.k

RRLMVVPRSNvrgvKYEPLVTEHIWMKSWPDHGTPEVES-FLRCMQAVRrDFEEPsgrVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRK
|.| |.  ..    |...    |   ..|.|.|.|.        |. |. . |.|   .|||||||.||| .||. ..|| ..     ...   . .||.
rtlevedstg....kfatrtvthyqysewtdrgvPkshaelfdlmelvk.ksekP...ivvhcsaGiGrsvafigteylareveadptieltealkhlre

HRRIMVQTASQYQ
||   ||| ||  
hrwngvqtnsqly
0044763 (Phosphotyrosine protein) phosphatases II 949-1154 7.3e-30 99.3 In-house 16-167 (178) alignment 
Range on Protein: 949-1154
Range on HMM: 16-167/178.0
AEGDYINANYMPnigHRPYIAAQGPlphteDDFWRMVYGEHSPLVIMLCSINP---RKCSPYFPQDPGasktfenftvtcqslvdaqvyerrrlmvvprs
  .|||||...    .. |.....|      |...... ..  ....|..  .    || ||.|.. |                                
ersdyinaseil...pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................................

nvrgvkyeplvTEHIWMkSWPDHGTPE-VESFLRCMQAVRRDFEEPSGRVVVHCSAGVGRSGTFIAFDMLADAiadghSMDVDAVVLQLRKHRRiMVQTA
            .....  .||||.|.  | ||........  .|. |.|.||||||||||||..| ...        ........ ..|..|. .|.. 
...........iqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnp

SQYQFIYEAL
.|....||  
gqlrqLyefe
0051429 (Phosphotyrosine protein) phosphatases II 951-1157 7.4e-41 135.9 In-house 4-224 (272) alignment 
Range on Protein: 951-1157
Range on HMM: 4-224/272.0
GDYINANYMPNIGH----RPYIAAQGPLPHTEDDFWRMvYGEHSPLVIMLCSIN---PRKCSPYFP----------QDPGASKTFENFTVTCQSLVDAQV
..||||....  |.    . .....||||.|..||||. . ..   ...|.| .     ||..| |           |   . .. ...||..| .   .
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YERRRLMVVPRSNVRGVkyepLVTEHIWMKSWPDHGTPEvESFLRCMQAVRRdfeepSGRVVVHCSAGVGRSGTFIAFDMLADAIADGHSMD--------
|  |.|...  ..   .    .   |... .|||||.|. |..|. ......     .|.|.||||||..|.||..| ..|.  . .   .|        
yilrellltlllsagea....revmhlhytdwpdhgvpq.eallellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

VDAVVLQLRKHRRIMVQTASQYQFIYEALKNP
....| .||..|. .|||  ||.|.||||.. 
leeaveelraqrpgavqteeqylflyeallel
0043147 (Phosphotyrosine protein) phosphatases II 951-1152 4.3e-39 129.4 In-house 5-155 (172) alignment 
Range on Protein: 951-1152
Range on HMM: 5-155/172.0
GDYINANYMPNIGH-RPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSInprkcspyfpqdpgasktfenftvtcqslvdaqvyerrrlmvvprsNVRG
 |||||.|..   . . .|| ||||..| .|||||.. ..  ....|..                                                . .
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................lydp

VKYEPLVTEHIWMkSWPDHGTPEVESFLRCMQAVRR-DFEEPSGRVVVHCSAGVGRSGTFIAFDMLAdaiadgHSMDVDAVVLQLRKHRRIMVQTASQYQ
 ..|.|. ..... .|||||.|  | .|.... ...   ..|.|.|.|||||||||.||..| ...       ...... .| ..|..|...||. |||.
ellerlgiqylyl.pwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyr

FIYE
|.|.
flyy
0046846 (Phosphotyrosine protein) phosphatases II 952-1155 2.8e-36 120.3 In-house 13-170 (176) alignment 
Range on Protein: 952-1155
Range on HMM: 13-170/176.0
DYINANYMPNigHRpYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSI---NPRKCSPYFPQDPGASKtfenftvtcqslvdaqvyerrrlmvvprsnvr
||||||..    .| .|| |||||.|  ||..|.. ..  .|..|..    .  ||  |.|.  ...                                 
dyinanlilg..sr.piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi................................

gvkyeplvteHIWMKSWPDHGTPEVESFLRCMQAVRRDFEEPsGRVVVHCSAGVGRSGTFIAFDMLADaiadGHSMDVDAVVLQLRKHRR-IMVQTASQY
          ...   |||||.|. | .|......|.  .|  |.|.||||||.||.||..| ..|      .. ..|. .. ..|..|.  .||| .||
..........qylhlpwpDhgvpdlelllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQy

QFIYEALK
.|.||...
rflyefel
0036282 (Phosphotyrosine protein) phosphatases II 952-1152 2.1e-34 114.1 In-house 3-164 (174) alignment 
Range on Protein: 952-1152
Range on HMM: 3-164/174.0
DYINANYMP-NIGHRPYIAAQGPLPhteddFWRMVYGEHSPLVIMLCSINPR---KCSPYFPQdpgasktfenftvtcqslvdaqvyerrrlmvvprsnv
|||||...  ..  . .|| ||||.     ||.|.. ...  |.||.. ...   ||  |.|                                      
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.....................................

rGVKYEPLVTEHIWMKSWPDHGTPEVESFLRCMQAVRRDFEE-PSGRVVVHCSAGVGRSGTFIAFDMLADAIAdGHSMDVDAVVLQLRKHRRIMVQTASQ
   ...     ...   |||||.|... .|.....|.. ..| |.| |.|||||||||.||..| ...   .     .|. ..| .||..|  |||| ||
.lredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YQFIYE
|.|.|.
yrflyy
0051082 (Phosphotyrosine protein) phosphatases II 952-1153 2.1e-27 91.0 In-house 4-148 (151) alignment 
Range on Protein: 952-1153
Range on HMM: 4-148/151.0
DYINANYMPNIghrpYIAAQGPLPhtedDFWRMVYGEHSPLVIMLCSINPRKCSPYFPQDPGasktfenftvtcqslvdaqvyerrrlmvvprsnvrgvk
||||..|. .     ... .|||.    ||..... ..   ...|.|  .|.  | . .. |                                      
dyinfsyvtgg....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg......................................

yepLVTEHIWMKSWPDHGTPEV-ESFLRCMQAVRRdfeEPSGRVVVHCSAGVGRSGTFIAFDMLADAiadghsMDVDAVVLQLRKHRRIMVQTASQYQFI
   .   ||.. .|||.|.|.  ...|. ......    ..| |.||||||.||.||..| ....        ....... ..|..|  .||.  |..|.
...ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

YEA
. |
lfa
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 963-1152 1.2e-15 52.3 In-house 3-198 (199) alignment 
Range on Protein: 963-1152
Range on HMM: 3-198/199.0
GHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSINPRKC---SPYFPQDPGASKTFENFTVTCQSLVDAQVYERRRLMVVPRSNVRGVKYEplvTEH
|.| |||.| || .|  |||.||.   |  ..|.   .  |    . |.|    ..  . ...||.....    |    |...  .       |     |
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstre...ish

IWMKSWPDHGTPEVESFLRCMQAV---RRDFE-EPSGRVVVHCSAGVGRSGTFIAFDMLADAIADGHSM--DVDAVVLQLRKHRRIMVQTASQYQFIYE
  . || .. ||.|  |.  . |     . .| |    |.|||| | | .| |.|.|.   .  . ..   |.  |  .||. |  .. .  .|.|||.
yqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 963-1152 1.2e-15 52.2 In-house 2-197 (198) alignment 
Range on Protein: 963-1152
Range on HMM: 2-197/198.0
GHRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSINPRKC---SPYFPQDPGASKTFENFTVTCQSLVDAQVYERRRLMVVPRSNVRGVKYEplvTEH
|.| |||.| || .|  |||.||.   |  ..|.   .  |    . |.|    ..  . ...||.....    |    |...  .       |     |
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstre...ish

IWMKSWPDHGTPEVESFLRCMQAV---RRDFE-EPSGRVVVHCSAGVGRSGTFIAFDMLADAIADGHSM--DVDAVVLQLRKHRRIMVQTASQYQFIYE
  . || .. ||.|  |.  . |     . .| |    |.|||| | | .| |.|.|.   .  . ..   |.  |  .||. |  .. .  .|.|||.
yqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
0049260 (Phosphotyrosine protein) phosphatases II 964-1152 4e-35 116.1 In-house 8-144 (152) alignment 
Range on Protein: 964-1152
Range on HMM: 8-144/152.0
HRPYIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSINPR---KCSPYFpqdpgasktfenftvtcqslvdaqvyerrrlmvvprsnvrgvkyeplvteHI
....||.|||.|.| .|||||..  .   ..||..  ..   ||  |.                                                  ..
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..................................................qy

WMKSWPDHGTPEVESFLRCMQAVRRD-FEEPSGRVVVHCSAGVGRSGTFIAFDMLAdaiadgHSMDVDAVVLQLRKHRRIMVQTASQYQFIYE
    |||||.|. . .|. .  . .   ....|.|.|||||||||.||..| ...       . .... .| ..|..| ..|.. .|..|.||
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 967-1025 1.3e-08 28.6 In-house 238-295 (440) alignment 
Range on Protein: 967-1025
Range on HMM: 238-295/440.0
YIAAQGPLPHTEDDFWRMVYGEHSPLVIMLCSINPRKCSPYFPQDpGASKTFENFTVTC
.||.| ||  |  ||||.|.  .   .|||  .| . || |.| .   | ||  |||  
fiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvn.trsvtfgpftvgh
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 973-1151 7.2e-17 55.8 In-house 99-281 (302) alignment 
Range on Protein: 973-1151
Range on HMM: 99-281/302.0
PLPHTEDDFWRMVYGEHSPLVIMLCSI---NPRKCSPYFPQDPGASKTFENFTVTCQSLVD--AQVYERR--RLMVVPRSNVRGVKYEPLVTEHIWMKSW
|   | . .| ..   .  .|. |||.   . .||..|. .. |   .| ..||.  |. .  ..  ...  .|  |   | .  |  .   . .   .|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHGTPEVESflRCMQAVRrDFEEPSGRVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIY
||||.|.       .. ..   |     |.|||||||||.||..|     .  .  .  |.  .|| .|. |   ||...|  .. 
pdhGapkeay..taldilk.fcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 977-1149 2.2e-16 54.7 In-house 40-212 (255) alignment 
Range on Protein: 977-1149
Range on HMM: 40-212/255.0
TEDDFWRMVYGEHSPLVIMLCSINP---RKCSPYFPQDPGASKTFENFTVTCQSLVDAQVYeRRRLMVvprSNVRGvKYEPLVTEHIWMKSWPDHGTPEV
| | |....    .  |.|||  .     ||| ||| .    . ... .||.   .   |  | . ..   |..   | .    .|   | |... .|| 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvl.rtleit...stlge.kkkthtvkhysykGWieknaPel

ESFLRCMQAVRRDfeepSGRVVVHCSAGVGRSGTFIAFDMLAD----AIADGHSMDVD--AVVLQLRKHRRIMVQTASQYQF
   .. .  | ||    |  ||||||.|.||| .|.  ...      ..   .  ..|   .. .||..|.  ..|  |  |
areilnilkvvrd....sksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf
subfamily_hpo-7_pd Subfamily hpo-7 977-1149 4.4e-14 47.0 In-house 46-218 (263) alignment 
Range on Protein: 977-1149
Range on HMM: 46-218/263.0
TEDDFWRMVYGEHSPLVIMLCSINPR---KCSPYFPQDPGASKTFENFTVTCQSLVDAQVYERRRLMvvprSNVRGvKYEPLVTEHIWMKSWPDHGTPEV
| | |....    .  |.|||  |     ||| ||| .    . ..| .|..   ..  .   . |.    |..   | .    .|   | |...  || 
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlell....stlge.KkkthtvkhysykgWiekndpel

-ESFLRCMQAVRRdfeepSGRVVVHCSAGVGRSGTFIAFDMLAD----AIADGHSMDVDA--VVLQLRKHRRIMVQTASQYQF
 .. |. ....|      | ..|||||.|.|||  |   ...      ..   .  ..|   .. .||..|.  ..|  |  |
areilnilkvarn.....skslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf
subfamily_PTEN_pd Subfamily PTEN 1051-1151 7.7e-08 27.5 In-house 72-173 (184) alignment 
Range on Protein: 1051-1151
Range on HMM: 72-173/184.0
KYEPL-VTEHIWMKSWPDHGTPEVESFLRCMQAVRRDFEEPSGRV-VVHCSAGVGRSGTFIAFDMLADAIADgHSMDVDAVVLQLRKHRRIMVQTASQYQ
||.   ..... .    || .|..| . .... ... .|| . .| |||| || ||.|. |.  .|   . . .. .. ..  . | . .  |.  ||  
kydskkfdgrvavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllksllle.kaeealelfaeaRtknkkgvtiPsqrR

FIY
...
Yve
0048076 (Phosphotyrosine protein) phosphatases II 1053-1154 7.4e-24 79.5 In-house 44-139 (145) alignment 
Range on Protein: 1053-1154
Range on HMM: 44-139/145.0
EPLVTeHIWMKSWPDHGTPEV-ESFLRCMQAVRRDFEEPsGRVVVHCSAGVGRSGTFIAFDMLADaiadgHSMDVDAVVLQLRKHRRIMVQTASQYQFIY
|.|.. ...  .|||||.|.  | .|........  .|. |.|.|||||||||.||..| ...       ...... .. ..|..|...|.. .|..|.|
erlgi.qylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrfly

EAL
|..
efe
PTPc_DSPc_SM00012 1058-1155 1.9e-29 97.3 In-house 3-104 (105) alignment 
Range on Protein: 1058-1155
Range on HMM: 3-104/105.0
EHIWMKSWPDHGTPE-VESFLRCMQAVRRDFEEP--SGRVVVHCSAGVGRSGTFIAFDMLADAIADG-HSMDVDAVVLQLRKHRRIMVQTASQYQFIYEA
 |.....|||||.|| ..|.|. ..||..  ..   |. |||||||||||.|||.|.|.| . . .. ...|.  .| .|||.|. ||||  ||.|.|.|
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyra

LK
|.
ll
0048179 (Phosphotyrosine protein) phosphatases II 1059-1152 1.4e-22 75.4 In-house 51-139 (144) alignment 
Range on Protein: 1059-1152
Range on HMM: 51-139/144.0
HIWMKSWPDHGTPEV-ESFLRCMQAVRRDFEEPsGRVVVHCSAGVGRSGTFIAFDMLAdaiadGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYE
...  .|||||.|.  | .|........  ||. |.|.|||||||||.||..| ...       . .... .. ..|..| ..|.. .|..|..|
qylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1059-1159 5.3e-14 46.4 In-house 93-195 (440) alignment 
Range on Protein: 1059-1159
Range on HMM: 93-195/440.0
HIWMKSWPDHGTPEVE-SFLRCMQAVRRDFEE-PSGRVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKN
.  ...|||.| |..    |. .| |    |.  .| ..||||||.||.|  || | .         .|. ...  .|. |  ||||  || |..||. .
qyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavle

PLC
 | 
gll
0038934 (Phosphotyrosine protein) phosphatases II 1060-1155 3.8e-12 41.7 In-house 80-174 (194) alignment 
Range on Protein: 1060-1155
Range on HMM: 80-174/194.0
IWMK--SWPDHG-TPEVESFLRCMQAVRRDFEE-PSGRVVVHCSAGVGRSGTFIAFDMLADaiadgHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALK
|      .||.| .|  |  || ...| . ..| |.| |.||| ||.||.||..|  ..       . |.... .  .|  |. .... .... ...  |
ieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr.....lgmsaeeAialfrekRpgaipnqdyleallkryk
subfamily_PTPDC1_pd Subfamily PTPDC1 1063-1152 8.6e-09 30.1 In-house 88-170 (182) alignment 
Range on Protein: 1063-1152
Range on HMM: 88-170/182.0
KSWPDHGTPEVESFLRCMQAVRRDFEEpsGRVVVHCSAGVGRSGTFIAFDMLADaiadgHSMDVDAVVLQLRKHRRIMVQTASQYQFIYE
 .|.|.|.. .|. |  .. |    .|  |.| ||| || || |  ||  ..       .... .  .  .|..|   .|| .| ... |
fgwkDygvasleriLdivkvvafalqe..gkvavhChaGlGrtGvliacylvya.....krltaekaiklvrskrpksiqtreqvelvke
PTEN_1 1064-1151 8.6e-11 37.0 In-house 101-186 (196) alignment 
Range on Protein: 1064-1151
Range on HMM: 101-186/196.0
SWPDHGTPEVESFLRCMQAVRRDFEE--PSGRVVVHCSAGVGRSGTFIAFDMLADAIadghsMDVDAVVLQLRKHR-RIMVQTASQYQFIY
...|||.|  .....    .     .  . . |.||| ||.||||| .|  ...        ...|  .  .|..| .......|| ....
pieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.....ltadeAlelvrekRppgapnspsqerlle
subfamily_CDKN3_pd Subfamily CDKN3 1064-1152 2.8e-06 21.0 In-house 106-190 (202) alignment 
Range on Protein: 1064-1152
Range on HMM: 106-190/202.0
SWPDHGTPEVESFLRCMQAVRRDFEEPSGrVVVHCSAGVGRSGTFIAFD--MLADAIADGHSMDvdaVVLQLRKHRRImvQTASQYQFIYE
  .| ..|.. | |. .. .|  ...  .  .|||  |.|||   ||    .| | |   ...|    . .|.  | |  ||  ||... |
piadglvpdiasclkileelrinlkayrk.tlvhcygglgrsslviaclllylddtiepkdaid...klrdlkgsrai..qtvkqynylse
subfamily_PTPMT1_pd Subfamily PTPMT1 1065-1149 4.2e-06 21.3 In-house 81-160 (171) alignment 
Range on Protein: 1065-1149
Range on HMM: 81-160/171.0
WPDHG-TPEVESFLRCMQAVRRdFEEPSGRVVVHCSAGVGRSGTFIAFDMLADaiadgHSMDVDAVVLQLRKHRRIMVQTASQYQF
 .|.  .|..|. .. .. ... . .   || ||| || |||.| .|  ..       . .. .  .  |.| |.|.     |.. 
tvDfteapdleklekgvefiek.vaskgkrvYvHCkaGrgRsatlvacylmkk.....eklspeeAlkalkkkRkiirlakkqwka
DSPc Dual specificity phosphatase, catalytic domain 1067-1148 4.7e-07 24.7 Pfam-A 50-125 (133) alignment 
Range on Protein: 1067-1148
Range on HMM: 50-125/133.0
DHGTPEVESFLRCMQAVRrDFEEPSGRVVVHCSAGVGRSGTFIAFDMLADaiadgHSMDVDAVVLQLRKHRRIMVQTASQYQ
.. |  .. . .... .. ..|.  ..|.||| ||. ||.|.|.  ..       ......  .  ... | .....|.. .
etetkiskeleeavefie.kaeqkgkkvlVHCqaGisRSatliiaYlmkt.....knlslneAyefvkerrskispnagflr
DSPc Dual specificity phosphatase, catalytic domain 1067-1148 4.7e-07 24.7 In-house 50-125 (133) alignment 
Range on Protein: 1067-1148
Range on HMM: 50-125/133.0
DHGTPEVESFLRCMQAVRrDFEEPSGRVVVHCSAGVGRSGTFIAFDMLADaiadgHSMDVDAVVLQLRKHRRIMVQTASQYQ
.. |  .. . .... .. ..|.  ..|.||| ||. ||.|.|.  ..       ......  .  ... | .....|.. .
etetkiskeleeavefie.kaeqkgkkvlVHCqaGisRSatliiaYlmkt.....knlslneAyefvkerrskispnagflr
PTPc_motif_SM00404 1075-1146 1.8e-07 26.2 In-house 65-130 (140) alignment 
Range on Protein: 1075-1146
Range on HMM: 65-130/140.0
SFLRCMQAVrRDFEEPSGRVVVHCSAGVGRSGTFIAFDMLADaiadgHSMDVDAVVLQLRKHRRIMVQTASQ
 . .... . ...|.  |.|.||| ||| ||.|.|.. ..       .........  ... | |. .... 
yldkvldfi.enaekkggkvlVHCqaGvSRSatliiaYlmry.....rqlslaeayefvkerRpiispnlnf
subfamily_CG42327_pd Subfamily CG42327 1084-1154 1.8e-15 51.4 In-house 240-311 (319) alignment 
Range on Protein: 1084-1154
Range on HMM: 240-311/319.0
RRDFEEPSGRVVVHCSAGVGRSGTFIAFDMLADAIADG-HSMDVDAVVLQLRKHRRIMVQTASQYQFIYEAL
|   .|  | .||||| ||||.|. || |.    . .  .|.|.  .| ..|. |   |.|  ||.|||  |
rsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1090-1155 5.1e-08 26.6 In-house 264-341 (349) alignment 
Range on Protein: 1090-1155
Range on HMM: 264-341/349.0
PSGRVVVHCSAGVGRSGTFIAFDMLAD--AIADGHS-------MDVDA---VVLQLRKHRRIMVQTASQYQFIYEALK
 .  ..|||||| ||.|... .|.| .       .|       .  |    .| .||| |  |||  .|. .||||| 
qlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealL
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1093-1154 2e-12 41.6 In-house 230-291 (297) alignment 
Range on Protein: 1093-1154
Range on HMM: 230-291/297.0
RVVVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEAL
 ..|||||||||||  .  |.... .  ..  || |.. .||. |  .|||  |....|.| 
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1095-1158 1.1e-10 35.7 In-house 2-65 (69) alignment 
Range on Protein: 1095-1158
Range on HMM: 2-65/69.0
VVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKNPL
|||||.| ||.|||||  .    |     .|.   |  .|| | .||    .| ||..|| . |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1095-1158 1.6e-10 35.1 In-house 1-64 (69) alignment 
Range on Protein: 1095-1158
Range on HMM: 1-64/69.0
VVHCSAGVGRSGTFIAFDMLADAIADGHSMDVDAVVLQLRKHRRIMVQTASQYQFIYEALKNPL
|||||.| ||.|||||  .    |     .|.   |  .|| | .||    .| ||..|| . |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
ETC_C1_NDUFA5 ETC complex I subunit conserved region 1232-1283 7.1e-17 47.3 Pfam-A 2-53 (57) alignment 
Range on Protein: 1232-1283
Range on HMM: 2-53/57.0
NPQEVLSGLYGATLQVVGRMPQSAAYRSKVEAITKERQAILEKSEDVDAFEA
|| . |  ||  ||...  .|....||  .||.|||| .| |..||| . | 
nPrsaLlalYtktLkkLkkiPedsvYRqstEaltkeRLkiveeeedvekiee