Gene MbrePTP-Un-5 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP059_AA protein Get Run
MbreP059_AA_489-740 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 482-736 1.3e-29 97.9 In-house 17-274 (287) alignment
Range on Protein: 482-736
Range on HMM: 17-274/287.0
EAVQTASaSVLTYQYQTAMLPHNLEKNvRRNTLLPYEYNRVLLANPGEKD-QYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTI
.|..  |    |. ...|    . .|| |   .||.. .||||.. ||.  .| || ....|  .   |.| ||   |.  ||......... |.. |  
dalkeds.esstatfkaaeelaavkkn.ryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtre

SDGSQVVGERYWPSEGDILEIGPLQIT-LEHEHTNLAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERV---RDARSKLKPDQPLL
 . ..    .|||     . .|   .. |...  .   . |.||. ...   .| || |..| | .. .   .  .. |.  |    ... . .   ||.
veearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlv

VHGITAVGRAGAFCALLNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVL
||  . .||.| . |.| |..|  .  |..|   . |||. |  ..  || |  .   . 
vhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 485-581 2.4e-07 24.6 In-house 15-111 (332) alignment
Range on Protein: 485-581
Range on HMM: 15-111/332.0
QTASASVLTYQYQTAMLPHNLEKNvRRNTLLPYEYNRVLLANPGEKDQYYNASFIPTYSPQMPIIVAEGPQR-PTLTLFWQMMWQQEVSLVAMTTTIS
.   .| .||      .  |.. | |   |  ....|| ||    ||..||||..  || .   |.|. |    |  .||.|. ... |.. .   | 
nqmhtsamtypntydkflnnmdmn.riphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdid

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 486-725 1.8e-38 127.5 In-house 38-276 (298) alignment
Range on Protein: 486-725
Range on HMM: 38-276/298.0
TASASVLTYQYQTAMLPHNLEKNvRRNTLLPYEYNRVLLAN--PGEKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDG
. | .. . ... |  |.| .|| |   ...... ||.| .    |. .| ||||. .|. . . |....|  .|.. ||.|....... . | |.. . 
svsseieeeekevarkpenkkkN.RyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleel

SQVVGERYWPSEGDiLEIGPLQITLEHEHTNLAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDaRSKLKPDQPLLVHGITAV
 ..  ..|||.||   . | ....| ....   .  | | |.. .   .| |. |..  |    . | ..  |.. ..||    .   ..|..|.    |
dktkyhkywPdegk.etygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGv

GRAGAFCALLNLLDRFDNERRLNVVDELTRLRQARSHFISDV
||.|.|.|.  .|.|  .|. . | . . .||. | . .   
gRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqte

DSPc_SM00195 490-739 9e-44 145.1 In-house 12-262 (263) alignment
Range on Protein: 490-739
Range on HMM: 12-262/263.0
SVLTYQYQTAMLPHNLEKNvRRNTLLPYEYNRVLLANPG--EKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVV
|  . . ..|  ..| .|| | .  |||. .|| | ..   |...|.||..| .....  .|.. ||.  |.  ||.|.|...|....|.|  ..  .  
stspketteaekkknkskn.RyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkek

GERYWPSE-GDILEIGPLQITLEHEHTNL-AICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLkpDQPLLVHGITAVGR
 .||||.| |.  ..| ....| ....    |  | |.... .   ||.|. .|.  |   .. .. . .|.. . |.  .|.   ..|..||  . |||
cdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgR

AGAFCALLNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDYA
.|.|...  .|.....| .... . ...||. | . ..    . .|  ..|.|.
tgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 490-739 9e-44 145.1 In-house 12-262 (263) alignment
Range on Protein: 490-739
Range on HMM: 12-262/263.0
SVLTYQYQTAMLPHNLEKNvRRNTLLPYEYNRVLLANPG--EKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVV
|  . . ..|  ..| .|| | .  |||. .|| | ..   |...|.||..| .....  .|.. ||.  |.  ||.|.|...|....|.|  ..  .  
stspketteaekkknkskn.RyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkek

GERYWPSE-GDILEIGPLQITLEHEHTNL-AICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLkpDQPLLVHGITAVGR
 .||||.| |.  ..| ....| ....    |  | |.... .   ||.|. .|.  |   .. .. . .|.. . |.  .|.   ..|..||  . |||
cdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgR

AGAFCALLNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDYA
.|.|...  .|.....| .... . ...||. | . ..    . .|  ..|.|.
tgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_PTPN6_pd Subfamily PTPN6 490-740 1.9e-29 97.7 In-house 40-298 (306) alignment
Range on Protein: 490-740
Range on HMM: 40-298/306.0
SVLTYQYQTAMLPHNLEKNVRRNtLLPYEYNRVLLANPGEKD-QYYNASFIPTY--SPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQV
.  ... . .  |.| |||  .|  ||.. .|| |..|. .. .| ||..| .   . .   | ..|  . |.. ||.|.||..  .. |||.  . .. 
akkllsrkegakpenkeknrykn.ilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgke

VGERYWPSEGDILEIGPLQITLEHEHTNLAICERSLRVKHI-DLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLK--PDQPLLVHGITAV
   ||||.| .  | | ...|  .|... .   |.|.|... . . .|.|  ..   |      .|   .|.| | |.  ...|.     |..||    .
kCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGi

GRAGAFCA---LLNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDYAA
|| |.|     ||.|. .  ..  ... .    .|. || ..        .   .  |  
GRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie

0050432 (Phosphotyrosine protein) phosphatases II 492-743 1.3e-53 177.7 In-house 56-303 (308) alignment
Range on Protein: 492-743
Range on HMM: 56-303/308.0
LTYQYQTAMLPHNLEKNVRRNtLLPYEYNRVLLanpGEKDQYYNASFIPTY--SPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGE
  ..| .|.|| | .||  ..  |||...|| |   .|.. |.|||....|    .. .|.. ||   |.  ||.|.|.|.|... | |.. . ...  .
plleysvallpenkdkNrykd.ilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekca

RYWPSE--GDILEIGPLQITLEHEHTNLAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARsklkPDQPLLVHGITAVGRAG
.|||.|  |..||.|....|| .|...  .. | |...... | .| |. .... |  . ....   .|.| |.||. .    |. | .||    |||.|
qYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl....pggpivVHCsaGvGRtG

AFCALLNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDYAANKD
.|.||. ||.... |....| . . .||. | . . .. ... .  ..|.|. .| 
tfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl

0046845 (Phosphotyrosine protein) phosphatases II 492-743 1.1e-52 174.5 In-house 16-278 (284) alignment
Range on Protein: 492-743
Range on HMM: 16-278/284.0
LTYQYQTAMLPHNLEKNVRRNtLLPYEYNRVLLANPGEK---DQYYNASFIPTY-----SPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDG
|.... .|.||.||.||  .. .|||...|| | .....   . |.|||....|       .. .|.. ||   |.  ||.|.|.|.|... | |.. . 
lllslsvallpenlsknRykd.ilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelven

SQVVGERYWPSEGDILEIGPLQITLEHEHTNLAICERSLRVKHID-LGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKPDQPLLVHGITA
...  ..|||.||. |..|....|| .|...  .. | |......  | .| |. .... |    .....  .|.| . ||.....|... | .||    
grekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaG

VGRAGAFCALLNLLDRFDNER---RLNVVDELTRLRQARSHFISDVVYLETILACVLDYAANKD
|||.|.|.||  ||.....|.   ...| . . |||. | ...  .  .. .  ..|.|. .| 
vgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl

0036941 (Phosphotyrosine protein) phosphatases II 492-743 5.3e-52 172.3 In-house 27-281 (297) alignment
Range on Protein: 492-743
Range on HMM: 27-281/297.0
LTYQYQTAMLPHNLEKNVRRNtLLPYEYNRVLLanPGEKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERY
| . . .|.|| |||||  ..  |||...|| |  ..|.. |.|||....|. .. .|...||.  |.  ||.|.|.| |. . | |.  .   .  ..|
llgslsvallpenleknRykd.ilpydhtRVkl..ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqy

WPSE-GDILEIGPLQITLEHEHT--NLAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKPDQPLLVHGITAVGRAGA
||.| |. |. |....|| ....  .  .. | |.|.... | .| |. .... |    . |.   .|.| |.||.....| .. | |||    |||.|.
wpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgt

FCALLNLLDRFD---NERRLNVVDELTRLRQARSHFISDVVYLETILACVLDYAANKD
|.|.  .|....    |....... .  ||. | . .  .  .. .  ..|..  .|.
fiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl

0043336 (Phosphotyrosine protein) phosphatases II 492-738 3.2e-45 150.1 In-house 33-276 (278) alignment
Range on Protein: 492-738
Range on HMM: 33-276/278.0
LTYQYQTAMLPHNLEKNVRRNtLLPYEYNRVLLANPGEK--DQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGE
 .. | .|.||.| .||  ..  |||...|| | . |.   . |.|||....|. .. .|.. ||.  |.  ||.|.|.. |. . | |.  . ..|   
kldtysiallpenkdknrykd.ilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkca

RYWPseGDILEIGPLQITLEHEHTNLAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSklKPDQPLLVHGITAVGRAGAF
.|||  |. |..|....||  |...  .. | |.|..   | .| |  .. | |  ....|.   .| | ..||.|..  ... |.|||    |||.|.|
qYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..dsngpvlVHCsaGvgRTGtf

CALLNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDY
.||. ||.....|..... . . .||. | . .    ... .  ..|.|
ialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley

subfamily_PTPN1_pd Subfamily PTPN1 492-725 1.5e-27 91.1 In-house 20-257 (290) alignment
Range on Protein: 492-725
Range on HMM: 20-257/290.0
LTYQYQTAMLPHNLEKNVRRNtLLPYEYNRVLLANpgEKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERY
  .. ..| ||.| ..|  |. . ||.. |. | .  .. .| |||..     .   |.. ||   | . ||||.|.|.   | |   . . .|.   .|
sdfptreaklpenrnlnryrd.vspydhsrikler..adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WPSEGD--ILEIG--PLQITLEHEHTNLAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKPDQPLLVHGITAVGRAG
||.. .   |..    |...| .|...     | |... .    ||..     . |      |    || |  .||.. |  .   | ..|  . .||.|
wPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsG

AFCA---LLNLLDRFDNERRLNVVDELTRLRQARSHFISDV
.||    .| |... |.   ... . |  ||. |  .|   
tfclvdtclvliekkddlssvdikkvllelrkyrlGliqta

0040438 (Phosphotyrosine protein) phosphatases II 493-749 3.1e-51 169.9 In-house 32-286 (317) alignment
Range on Protein: 493-749
Range on HMM: 32-286/317.0
TYQYQTAMLPHNLEKNVRRNtLLPYEYNRVLLANPGE--KDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGER
 . |..|.|| | .||  ..  |||...|| | ..|.   . |.|||...... .. .|.. ||.  |.  ||.|.|.| |... | |.  . ...  ..
ldtysvaelpenkdknrypd.ilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaq

YWPSeGDILEIGPLQITLEHEHTNLAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSklKPDQPLLVHGITAVGRAGAFC
|||. |. |..|....||  |...  |. | |.|.. . . .| |. .....|  . . ..   .|.| |.||.|..  .|. |.|||    |||.|.|.
Ywpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGtfi

ALLNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDYAANKDKGLPLQ
|.. .|.... |....| . . .||..|.. .    ... .  ..|.|  .|..  |..
aaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepas

0051299 (Phosphotyrosine protein) phosphatases II 493-739 7.6e-51 168.6 In-house 38-286 (288) alignment
Range on Protein: 493-739
Range on HMM: 38-286/288.0
TYQYQTAMLPHNLEKNvRRNTLLPYEYNRVLLANPGE--KDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGER
.... .|.||.||||| |   .|||...|| | ....   . |.|||.|..|  ..  |...||   |.  ||.|.|.|.|... | |.. . ...  ..
dltlsaallpenlekn.RysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaq

YWPSeGDILEIGPLQITLEHEHTNLAICERSLRVKHI----DLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSklKPDQPLLVHGITAVGRA
|||. |. |..|....|| .|...  .. | |.|...      | .| |. .... |    . ..   .|.| ..||.|..  ... | .||    |||.
Ywpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..sgggpvvVHCsaGvgRt

GAFCALLNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDYA
|.|.||. ||.....|....| . . |||. | . .  .  .. .  ..|.|.
gtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0047943 (Phosphotyrosine protein) phosphatases II 493-738 1.1e-50 168.0 In-house 27-271 (273) alignment
Range on Protein: 493-738
Range on HMM: 27-271/273.0
TYQYQTAMLPHNLEKNVRRNtLLPYEYNRVLLanPGEKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYW
 . |..|.||.|..||  .. .|||...|| |  ..... |.|||....|  .. .|...||   |.  ||.|.|.| |... | |.. . ...  ..||
lltysvallpenkdknrykd.ilpydhsrvkl..gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYw

PSEGD--ILEIGPLQITLEHEHTNLAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKPDQPLLVHGITAVGRAGAFC
|.||.   |. |....||  |.|.  .. | |...... | .| |. .... |    ....   .| | | ||.|...|. . | .||    |||.|.|.
pleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfi

ALLNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDY
||. |||..  |....| . . .||. | . .  . ... .  ..|.|
aldllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley

0045450 (Phosphotyrosine protein) phosphatases II 493-739 7.3e-47 155.9 In-house 44-304 (307) alignment
Range on Protein: 493-739
Range on HMM: 44-304/307.0
TYQYQTAMLPHNLEKNVRRNtLLPYEYNRVLLANPGEK---DQYYNASFI--------PTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTIS
 . | .|.||.| .||  ..  |||...|| | .....   . |.|||..        ..|  .. .|.. ||.  |.  ||.|.|.| |... | |.  
lgeysiallpenkdknrykd.ilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelv

DGSQVVGERYWPSEGDILEIGPLQITLEHEHTNLAICERSLRVKHI-DLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKPDQPLLVHGI
.  ..   .|||.||. |..|....||  |..   .. | |.|..    | .| |. .... |  . ....   .|.| |.||.|...|... | |||  
elgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCs

TAVGRAGAFCALLNLLDRFDNERR---LNVVDELTRLRQARSHFISDVVYLETILACVLDYA
  |||.|.|.|.. .|.....|     ... . . .||. |.. .    ... .  ..|.. 
aGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_PTPRG_pd Subfamily PTPRG 493-724 7.3e-32 105.3 In-house 36-272 (563) alignment
Range on Protein: 493-724
Range on HMM: 36-272/563.0
TYQYQTAMLPHNLEKNvRRNTLLPYEYNRVLLAN-PGEKDQ--YYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGE
. .....  |.| .|| |   ...|.  || |.. ||.|..  | ||..|  |  .   |.. || . |.  ||.|.|.|.|... | | . .  .   .
dldaehsqkpenkrKn.RylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcd

RYWPSeGDILEIGPLQITLEHEHTNLAICERSLRVKHIDLGITRD------VKLLQMLFWVAGEACEDSHRFLAFAERVrdARSKLKPDQPLLVHGITAV
.|||.  . ...| ||.||..|..     .|.| .|.. |  ...      |.  ..  |    . | |   | |...   .... .   |..||  . |
vYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks..saankaeaGPivvHcsaGv

GRAGAFCALLNLLDRFDNERRLNVVDELTRLRQARSHFISD
||.| ...|  || .  .|   || . | ..|  | . . .
grtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqt

subfamily_PTPN12_pd Subfamily PTPN12 493-738 2.8e-30 100.2 In-house 29-276 (290) alignment
Range on Protein: 493-738
Range on HMM: 29-276/290.0
TYQYQTAMLPHNLEKNvRRNTLLPYEYNRVLLANPGEKD--QYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGER
.|. ...  ..| .|| |   .|||...|| | .  |..  .| ||.||   . ..  | | ||   ||. ||.|.|...|..| |   . .  .   ||
vysteagekeenvkkn.rykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPSEGDI-LEIGPLQITLEHEHTNL-AICERSLRVKHIdlGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSklKPDQPLLVHGITAVGRAGA
|||.||.  ||.|....|||.|..    .  |.|.|..   . .| |. ..   |   .  .  .. |.. | ||. ..  . |.||.||    |||.|.
YWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGt

FCALL---NLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDY
 .|.    .|| .   . .|.| | ...||. |.  .      | .  .|...
iiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 493-736 1.5e-16 54.9 In-house 35-276 (439) alignment
Range on Protein: 493-736
Range on HMM: 35-276/439.0
TYQYQTAMLPHNLEKN-VRRNTLLPYEYNRVLL-ANPGE-KDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQvvge
 |. ..... .. ..   | . . .... || |   ||  . .|.|| .|  |  .   | ..||.. |   ||...... .. . | | . .  .    
dyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk....

rYWPSEGDILeIGPLQITLEHEHTNLAICERSLRVKHIDLGITRDVKLLQ--MLFWVAGEACEDSHRFLAFAERVRDARSKlKPDQPLLVHGITAVGRAG
 ||||....   | . .  ...      . | ..|        ..  .||   . |   .   ..   | |   .  |  | .   |..||  . |||.|
.ywpsdaevc.ygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandk.eeygpvvvhcsagvGrtG

AFCALLNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVL
.  ||   |...  | ....   .. ||. | ... ...    |  .||
tiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavl

0039614 (Phosphotyrosine protein) phosphatases II 494-743 6.7e-45 149.2 In-house 46-293 (297) alignment
Range on Protein: 494-743
Range on HMM: 46-293/297.0
YQYQTAMLPHNLEKNVRRNtLLPYEYNRVLLANPGEK---DQYYNASFIPTYSP-QMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQvVGE
  | .|.|| | .||  ..  |||...|| |  ...    . |.|||....|.  .. .|.. ||.  |.  ||.|.|.| |. . | |.  . ..   .
pdysiallpenkdknrykd.ilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kca

RYWPSEGDilEIGPLQITLEHEHTNLAICERSLRVKHidLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKPDQPLLVHGITAVGRAGAF
.|||.||.  . |....||  ....  .. | |.|..   | .| |. .| . |  . .....  .| | | ||.|...|... | |||    |||.|.|
qywpeegg..tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtf

CALLNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDYAANKD
.|.. .|.... |....| . . .||..|.. .    ... .  ..|..  .|.
iaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl

0045098 (Phosphotyrosine protein) phosphatases II 494-739 3.3e-41 136.9 In-house 23-272 (278) alignment
Range on Protein: 494-739
Range on HMM: 23-272/278.0
YQYQTAMLPHNLEKNvRRNTLLPYEYNRVLlanpgekDqYYNASFIPTYspQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWP
... .|... ||.|| |    |||...||        | | |||.|..|  ..  |.. ||   |.  ||.|.|.. .. . | |.  .....  ..|||
seitpalylgnldkn.RykdilpydhsrVk.......d.YINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp

SeGDILEIGPLQITLEHEHTNLAICERSLRVKHI----DLGITRDVKLLQMLFWVAGEACEDS--HRFLAFAERVRDARS-----------KLKPDQPLL
. |. |..|....||. |...  .. | |.| ..      . .| |. |..|.|  ... ...    || . |..|.|..            | .. | |
e.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

VHGITAVGRAGAFCALLNLLDRFdnERRLNVVDELTRLRQARSH-FISDVVYLETILACVLDYA
||    |||.|...|.  .|...  |..... . .. ||. | .  .     .. .  ..|.. 
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 494-724 1.7e-29 97.7 In-house 34-262 (315) alignment
Range on Protein: 494-724
Range on HMM: 34-262/315.0
YQYQTAMLPHNLEKNVRRNtLLPYEYNRVLL--ANPGEKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERY
|. ..|  . | .||  .|  ||.. .|| |   .   .. |.|||.|...  .   | . ||.. ..  ||.|..|..|. ..| |  ..| ..   .|
yrqrvaretinfkknrykn.ilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqy

WPS-EGDILEIGPLQITLEHEHTNLAICERSLRVKHIDlgITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDArsKLKPDQPLLVHGITAVGRAGAFC
||  ..|  | | ....|   ...     | | ... .   .| |   |.  |    . ...  .| .   |.    . | . .||||  . |||.| ..
wPdrkadsvefGsikvellsleadtdgvarklvtrkse..esrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGrtGvvi

ALLNLLDRFDNERRLNVVDELTRLRQARSHFISD
.. . ...  ..| ..| . .. ||. | ...  
sidevvaqikrtrsvdvfnfvknlrakrpylvqt

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 494-737 1.4e-18 61.5 In-house 35-234 (392) alignment
Range on Protein: 494-737
Range on HMM: 35-234/392.0
YQYQTAMLPHNLEKNVRRNtLLPYEYNRVLL--ANPGEKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSqvvgery
|. ..|  . ||.||  .|  |||. .|| |   .   ...|.|||.||..  .   | ..||.  .|  ||.|..|..|. .|| | . .|        
ypqtvaqkeinlkknrykn.ilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.......

wpsegdileigplqitlehehtnlaicerslrvkhidL-GITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKpdQPLLVHGITAVGRAGAFC
                                         .| |   ..  |   .  . .  .| | . |.    .    .||..|  ..|||.|   
.....................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyt..hpliihcsagvgrtgvvi

ALLNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLD
.. ... .  . | ..|.. .| .|. | ...        | ..||.
sidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle

subfamily_PTPRD_pd Subfamily PTPRD 495-724 3.5e-43 143.1 In-house 39-266 (564) alignment
Range on Protein: 495-724
Range on HMM: 39-266/564.0
QYQTAMLPHNLEKNvRRNTLLPYEYNRVLLAN-PG-EKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYW
. ..|  |.| .|| | .  ..|. .|| | . .| |.  | ||||| .|  .   | . ||  .|.  ||.|.|.|..| . | | ... ..|  ..||
tweaankpaNkaKN.RyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYW

PSEGdILEIGPLQITLEHEHTNLAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSklKPDQPLLVHGITAVGRAGAFCAL
|..|   ..| |..|||.|..   .. |....|. .   .| |.  .   |    . |    .|.. ..||....  .  .|..||    ||| |.|...
Pekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne..pdagPivVhCSaGVGRTGtfivi

LNLLDRFDNERRLNVVDELTRLRQARSHFISD
  .|.|  .|. ...   ...||. | . .  
damlerikeektvDiyqyvkalrkqRnamVqt

0040439 (Phosphotyrosine protein) phosphatases II 495-739 5.2e-43 142.8 In-house 2-246 (249) alignment
Range on Protein: 495-739
Range on HMM: 2-246/249.0
QYQTAMLPHNLEKNVRRNtLLPYEYNRVLLANPGE--KDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYW
.| .|.|| |..||  ..  |||...|| |   ..   . |.|||.|..|  .. .|.. ||   |.  ||.|.|.. .. . | |.     ..  ..||
eysvallpenkdknrypd.ilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PSeGDILEIGPLQITLEHEHTNLAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKPDQPLLVHGITAVGRAGAFCAL
|. |. ||.| ...|| .....  .. | |.....  | .| |. .|.. |    ....   .|.| |.||.|...|... |.|||    |||.|.|.|.
pl.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

LNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDYA
. .|.... |..... . .  ||..|.. .    ... .. ..|.. 
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_PTPRB_pd Subfamily PTPRB 495-742 1.8e-38 127.2 In-house 42-288 (293) alignment
Range on Protein: 495-742
Range on HMM: 42-288/293.0
QYQTAMLPHNLEKNVRRNtLLPYEYNRVLLANP--GEKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYW
. ..| |. | .||  .| .|||...|| ||.    ... | ||..|| |. .   |.. ||   |.  ||.|.|....| . | | . .. .|  |.||
avkaaelavnraknrytn.ilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYW

PSEGDILEIGPLQITLEHEHTNLAICERSLRVKHidLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKPDQPLLVHGITAVGRAGAFCAL
|.. .    | ...|| .|..      |.|....     .|.|. .. . |.  .  |... .|.| ..||.| .| . ..|..||    |||.|.| ||
PadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfial

LNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDYAANK
 .||.. ..|  ....  ...||. | ...  .     |  ||||.  .|
drllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk

subfamily_PTPN14_pd Subfamily PTPN14 495-738 2.2e-37 123.7 In-house 40-295 (300) alignment
Range on Protein: 495-738
Range on HMM: 40-295/300.0
QYQTAMLPHNLEKNVRRNtLLPYEYNRVLLAN-PGEKDQYYNASFIPT--YSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERY
...|| || | |||  .. .|||| ||| |.    ....| ||| | .   . ..  ||| ||.. |.. ||||.|.|.|.|..| | . .. .    .|
llstaklpenaeknrfkd.vlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfky

WPSE---GDILEIGPLQITLEHEHTNLAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKPDQ-------PLLVHGIT
.|..    . .| |  ..| .  ..  ..  ..|..||.  .  |.|  ||   |   .  || . || . |.|.  | | .  .       |.|||   
fPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsa

AVGRAGAFCALLNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDY
 |||.|       |.  .........   |.|||. | .... .   . .   .. |
GvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 495-743 7.1e-35 115.6 In-house 39-287 (319) alignment
Range on Protein: 495-743
Range on HMM: 39-287/319.0
QYQTAMLPHNLEKNvRRNTLLPYEYNRVLLAN-PGE-KDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYW
....|  ..| .|| | . .|.|.  || |.. .|  . .| ||||| .|  .   | . .|   |.  ||.|.|..|.| | | | ...  .|  ..||
tfdsaskeenkkkn.ryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkyw

PSEgDILEIGPLQITLEHEHTNLAICERSLRVKHIDLGI-TRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKpDQPLLVHGITAVGRAGAFCA
|.| .. | | | .|||.|.    .  | | ...    . ||.||  | . |   .  |..   |.. .|.| .|.| . ..|. ||    ||| |.|..
pee.nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektq.sgPivvhCsaGvGRtGtfiv

LLNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDYAANKD
|   |.|  .|  |.|     |||  |   ..     . |   .|...   |
ldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd

subfamily_PTPRA_pd Subfamily PTPRA 495-745 1.2e-33 111.4 In-house 49-301 (330) alignment
Range on Protein: 495-745
Range on HMM: 49-301/330.0
QYQTAMLPHNLEKNvRRNTLLPYEYNRVLLANP-G-EKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYW
 ...|    | ||| |   .|||...|| |..  | |.  | |||||  |  .   | | ||.. |.  ||.|.|.|. . . | | . .  .   ..||
tlelaskeenkekn.rvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw

PSEGdILEIGPLQITLEHEHTNLAICERSLRVKHIDLGI----TRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKPdqPLLVHGITAVGRAGA
|.|| ..  | .....|.|    ..  | . |...  .     .| |. . .  |       ..   | . ..|.  . .     |. ||  . |||.|.
PdeG.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag..pivvhcsaGvGrtGt

FCALLNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDYAANKDKG
|..| ..|.|   ||...| . . |||. |.. .      | |   .|.|    |  
fivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdte

subfamily_PTPN9_pd Subfamily PTPN9 495-743 5.2e-32 106.0 In-house 33-294 (297) alignment
Range on Protein: 495-743
Range on HMM: 33-294/297.0
QYQTAMLPHNLEKNvRRNTLLPYEYNRVLLANPGEKD--QYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYW
......|. ||||| | . .| |.  || ||.  |..   | ||.|.  |  .  .| . || . | . ||.|.|.|||  . ||| . .  ..   .||
tflasklranlekn.rytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyW

P-SEGDILEIGPLQITLEHEHTNLAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKL----------K-PDQPLLVHGI
| .|..  | | |...  . ... .  .|.| .|... . .| |   |.| |      .... .| . | ||......          .  . |..||  
pleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcs

TAVGRAGAFCALLNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDYAANKD
. .||.|.|..|   |.|....  ..||. . .||. |.. |      |    .||.|| ...
aGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalelk

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 495-739 2.5e-29 97.4 In-house 39-288 (325) alignment
Range on Protein: 495-739
Range on HMM: 39-288/325.0
QYQTAMLPHNLEKNVRRNtLLPYEYNRVLLANPGEK--DQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMM--WQqevSLVAMTTTISDGSQVVGER
 ...||.|.| .||  .| ..... .|| |   ...    |.|||.. ..  .   . |  |.  |.  .|...  |.   . | . . . |. .     
akkvamkpenkaknrfkn.vvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcav

YWPSE-GDILEIGPLQITLEHEHTNLAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARS----KLKPDQPLLVHGITAVGR
||| | |.  . |.|.. |    .      | | || .. | || || .|.  |      .    .... . |         . |   |.||| .. |||
ywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGr

AGAFCALLNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDYA
.|.| .|  .|..  .| |... . . .||. |   .  |     |  .. .. 
tGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay

subfamily_PTPN3_pd Subfamily PTPN3 496-736 3.1e-38 126.3 In-house 33-272 (280) alignment
Range on Protein: 496-736
Range on HMM: 33-272/280.0
YQTAMLPHNLEKNVRRNtLLPYEYNRVLLANPGEkdQYYNASFIPTYSPQMP----IIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERY
 ..| .|.||.||  |. .|||.  || | .      | ||...   .| .      |.. || . | | ||||.|.|..||. | ||. .  .|   .|
isaarkpenlsknryrd.ilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WPSEGDILEIGPLQITLEHEHTNLAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKlkPDQPLLVHGITAVGRAGAFCA
||...| || | .....|.|... ... | | .|. .    | .  || | |   .  .||. || | ||||..||    ..|..||  . .||.| . .
WPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg..keePvvvhCsaGigrtGvlil

LLNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVL
|   |   .... ....| . ..|. |. ..  .   . .  ..|
letalalieaaepvypldivrtmrdqramlvqtasqykfvCeail

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 496-739 2.8e-35 116.8 In-house 39-279 (288) alignment
Range on Protein: 496-739
Range on HMM: 39-279/288.0
YQTAMLPHNLEKNVRRNtLLPYEYNRVLLAN--PGEKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWP
 ... |..| .||  ||  |||...|| | .   ...  | |||.|  .  .   | . ||   |.  ||........| ..| | . .| .   |.|||
vtagrlavnakknRyrn.ilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWP

SEGDILEIGPLQITLEHEHTNLAICERSLRVKhiDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLkpDQPLLVHGITAVGRAGAFCALL
....  . | ...|| ....   . .|.| ..    .  .... .| | |.  .  |... .|.. . |  | ..    .|..||    |||.| | || 
dadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad..tgpiivhCsaGvGrtgtFiald

NLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDYA
.|.|. ..|  ..|.. ...||. |  ..  .   | |  ..|. .
alidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 496-736 1.4e-34 114.6 In-house 38-277 (318) alignment
Range on Protein: 496-736
Range on HMM: 38-277/318.0
YQTAMLPHNLEKNvRRNTLLPYEYNRVLLANPG--EKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWP
   .. | |  || | . .|.|.  ||.| .    |.  | ||..|. |  .   | | .|   |.. ||.|.|.|. ... | | ... ...  .||||
slkslepvnkakn.ryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWP

SEGDIlEIGPLQITLEHEHTNLAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKlKPDQPLLVHGITAVGRAGAFCALL
|.| . ..| |...|..| .      |...|.. .   .|.|.  ..  |      |..  .|..  .|. |  | .  .|..||  . |||.| |.|. 
skgsr.sygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqk.sgagpivvhCsaGvGrtGvfiavd

NLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVL
 ||.|  .|  ..| .  ..||. |   .      | |   .|
illerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvll

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 496-737 7e-30 99.4 In-house 53-289 (319) alignment
Range on Protein: 496-737
Range on HMM: 53-289/319.0
YQTAMLPHNLEKNvRRNTLLPYEYNRVLLAN--PGEKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTtisdgsQVVGERYWP
 . | |..| .|| |   .|... |.| | .    |   | ||||.  |  .   | | ||.  ||  ||.|.|....| . . |      .    .|||
qtfanldqnkdkn.riinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywp

SEGDIL-EIGPLQITLEHEHTNLAIceRSLRVKH-IDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKPDQPLLVHGITAVGRAGAFCA
 ...|  | . ..... .|  . ..  |.... .       |...   .| |      . .  .. . ..||  .|| .  ....||  . |||.|.. .
lkivikeerfkvkvdsveetaeyvv..rdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyiv

LLNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLD
|  ||||...|....| . .  ||| |.... |.|    | . .|.
ldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 496-737 7.1e-30 99.5 In-house 17-253 (284) alignment
Range on Protein: 496-737
Range on HMM: 17-253/284.0
YQTAMLPHNLEKNvRRNTLLPYEYNRVLLAN--PGEKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTtisdgsQVVGERYWP
 . | |..| .|| |   .|... |.| | .    |   | |||||  |  .   | . ||.  ||  ||.|.|....| . . |      .    .|||
qtfanldqnkdkn.righilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

SEGDIL-EIGPLQITLEHEHTNLAIceRSLRVKH-IDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKPDQPLLVHGITAVGRAGAFCA
 ...|  | . ..... .|  . ..  |.... .       |...   .| |      . .  .... ..||  .|| .  ....||  . |||.|.. .
lkivikeerfkvkvdsveeseeyvv..rdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyiv

LLNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLD
|  ||||...|....| . .  ||| |.... |.|    | . .|.
ldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_egg_pd Subfamily egg 496-692 3.5e-07 24.2 In-house 32-221 (307) alignment
Range on Protein: 496-692
Range on HMM: 32-221/307.0
YQTAMLPHNLEKnVRRNTLLPYEYNRVLLANPG--EKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVvgERYWP
..||.   |||| .| . .   .. || |  .     |..  |  .         |.|. | . |   ||.|..|.||  . | |.  .  .   | |||
lttaasdnnlek.arskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserc..eyywp

-SEGDILEI--GPLQITLehEHTNlAICERSLRVKHIDLgITRDVKLLQMLFWVaGEACEDSHRFLAFaERVRDARSKlkpDQPLLVHGITAVGRAGAFC
 .| | | .  | |.|.    . .    .  .|| .. | .  | . . .  |  |.  . |. .  . . .| .|      .| .|. |  | .|... 
kaesdslvtvpGslrien..lkvd.skadplfrvtklkl.vGgddeerflehwq.gdvnnssdvyspl.rvlrklrnl...skpvvvqdilGvskaatlv

AL
|.
ai

0042113 (Phosphotyrosine protein) phosphatases II 497-738 3e-41 136.8 In-house 2-242 (245) alignment
Range on Protein: 497-738
Range on HMM: 2-242/245.0
QTAMLPHNLEKNVRRNtLLPYEYNRVLLANPGEK--DQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPS
..|.||.| .||  ..  |||...|| | ..|.   . |.|||....|     .|.. ||.. |.  ||.|.|.. .. . | |.  . ..|  ..|||.
svallpenkdknrysd.ilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

eGDILEIGPLQITLEHEHTNLAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKlKPDQPLLVHGITAVGRAGAFCALLN
 |..|..| ...||  |...  .. | |.|...  . .| |  .. | |  . .....  .| | |.||.|... ... |.|||    |||.|.|.|.. 
.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaayl

LLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDY
.|.... |..... . . .||. |.. .    ... .  ..|..
mleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel

0037934 (Phosphotyrosine protein) phosphatases II 497-737 1.6e-35 118.2 In-house 3-240 (243) alignment
Range on Protein: 497-737
Range on HMM: 3-240/243.0
QTAMLPHNLEKNVRRNtLLPYEYNRVLLanPGekDQYYNASFIPTYsPQmpIIVAEGPQRPTLTL----FWQMMWQQEVSLVAMTTTISDGSQVVGERYW
 .|.|| ||.||  ..  |||...|| |  .|  . |.||..|. . |.  .|.  ||   |.      ||.|.|.. .. . | |.  . ...  ..||
siallpenlsknrysd.ilpydhsrvkl..eg..sdyinanliyvt.pr..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PseGDIlEIGPLQITLEHEHTNLAICERSLRVKHID-LGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSK------LKPDQPLLVHGITAVGR
|  |.. ..|....|| .|..   .. | |.....|  . || |  .. | |  . . ..   .|.| . ||.  ..      |... |.|||    |||
p..gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

AGAFCALLNLLDRFdnerRLNVVDELTRLRQARSH-FISDVVYLETILACVLD
.|...|.. .|...    .... . . .||. |..  .    ... .  ..| 
tGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_PTPRK_pd Subfamily PTPRK 497-725 5.5e-28 92.7 In-house 36-263 (314) alignment
Range on Protein: 497-725
Range on HMM: 36-263/314.0
QTAMLPHNLEKNvRRNTLLPYEYNRVLLAN-PGE-KDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPS
..|   .| ||| | . .|.|.  || |    |. . .| ||..| .|      ||. || . |.. ||....... . . | | . . ..|   .||| 
daakkdenrekn.rsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

EGDIleIGPLQITLEHEHTNLAICERSLRVKHIDLG--ITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKlkPDQPLLVHGITAVGRAGAFCAL
....   |.....| . ...  .  | .||...  |   .| |. .| | | . .     . .|..  ||   . .   . ...||  .  ||.|.|.|.
dtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiai

LNLLDRFDNERRLNVVDELTRLRQARSHFISDV
  .||  ..|. ..|      ||. .. ..   
divldmieregvvdvfnavktlrsrkvnmvete

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 497-736 1.7e-25 84.6 In-house 21-265 (274) alignment
Range on Protein: 497-736
Range on HMM: 21-265/274.0
QTAMLPHNLEKNvRRNTLLPYEYNRVLLANPGEKD---QYYNASFIPTYSPQMPIIVA-EGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYW
.  ... . .|| | .|.|| |  |||| .   .|   .| || .|  |. .  . ||  ||   |.. ||.|..|.||... |.| ...  .   ..|.
eeldvfgsqtkn.ryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyf

PSEGDI---LEIGPLQITLEHEHTNLAICERSLRVKHIDLgiTRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKPD-QPLLVHGITAVGRAGA
| . |.    . | ..|. |.  ..     |.| .|.     .|.||      |   .. .| . .| . . |...|.. .    | .||    .||.|.
Pdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGc

FCALLNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVL
| | .. . ....|  ..|.   . ||. |   .      | |   . 
fiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc

subfamily_PTPN23_pd Subfamily PTPN23 498-741 1.5e-39 130.6 In-house 37-282 (288) alignment
Range on Protein: 498-741
Range on HMM: 37-282/288.0
TAMLPHNLEKNvRRNTLLPYEYNRVLLAnpGEKDQYYNASFIPTYSPQMP-IIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSE-
.|.   . ||| | . .|||. ||| |   |.|| | ||||.   ||. | .|.. .|...||  ||.|...| .|.. | .. ..  .   .||||.. 
iaiaklysekn.rsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedk

GDILEIGPLQITLEHEHTNLAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRD--ARSKLKPDQPLLVHGITAVGRAGAFCALL
|.  . |.|..||.....     || |.... |   ...|..||.  |    . .  . .|.| . |..     . | ..||.||  . |||.|.|. . 
getvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvy

NLLDRFDNERRL-NVVDELTRLRQARSHFISDVVYLETILACVLDYAAN
  .  ....  | .... . |||. | . ....  |.  .  || .| .
aavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 498-740 1.4e-38 127.4 In-house 40-284 (290) alignment
Range on Protein: 498-740
Range on HMM: 40-284/290.0
TAMLPHNLEKNvRRNTLLPYEYNRVLLA-NPGEKD---QYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWP
... . | ..| | .....|. ||. |   .|.||   .| ||..|  |. .   |...||   ||  ||...||..|. . | |.| .  .|.   |||
vgltssnklln.RfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWp

SEgDILEIGPLQITLEHEHTNLAICERSLRVKHIDL-GITRDVKLLQMLFWVAGEACED-SHRFLAFAERVRDARSKLkpDQPLLVHGITAVGRAGAFCA
.. |  ..|. .|.| .|.|   . || |.||. .  | .. |. .|.  |   . ... .   |...|...  | .   .....||   .|||.. |||
ds.dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg..ntsivvHCSdtvgrsavfca

LLNLLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDYAA
. . ...   |   .|.. | ..|. .   .  |. ...|   || |  
aattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 498-736 3.1e-31 103.5 In-house 43-276 (315) alignment
Range on Protein: 498-736
Range on HMM: 43-276/315.0
TAMLPHNLEKNvRRNTLLPYEYNRVLL--ANPGEKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSE
.|   .| .|| |    ..|.  || |   .  .. .| ||.||. |. .   | |.||.  ..  ||......... . | | . .| .   |.||| .
vakkienkqkn.ryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk

gdILEIGPLQITLEHEHTNLAICERSLRVKHIDlgITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKpdQPLLVHGITAVGRAGAFCALLNL
   .  |.. .|.  |  |  .. |.| |   |    |.|  |..  |   . .. .  .. .  .|.  . .     ...||    |||.|.|..|  .
..kviyGkitvtrkseevnteytvrtlsvvfgd..nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldav

LDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVL
||. . |. ..| . .|..|| | . .. .   . |   .|
ldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall

subfamily_PTPRN_pd Subfamily PTPRN 498-737 4.5e-29 96.1 In-house 50-290 (297) alignment
Range on Protein: 498-737
Range on HMM: 50-290/297.0
TAMLPHNLEKNvRRNTLLPYEYNRVLLANP--GEKDQYYNASFIPTYSPQMPIIV-AEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPS
.|  ..|..|| | ...|||. .|| | .    ||..| |||.|    |..|. . ..||   |.. ||||.|.| | .. . |.... .    .|||| 
vakaeknvkkn.rskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpd

EGDI-LEIGPLQITLEHEHTNlAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKlkPDQPLLVHGITAVGRAGAFCALL
||    .|  ...  ||  ..     ||. .| ..   || |  .  | | . ..   .. .| |  .|  .        |..||.   .||.|..... 
eGsevyhiyevhlvsehiwcd.dylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG..rscpivvhcsdGaGrtGvyilid

NLLDRFDN-ERRLNVVDELTRLRQARSHFISDVVYLETILACVLD
 .|.|. .  ......  |  ||. |....     .| .|..| .
lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae

0049772 (Phosphotyrosine protein) phosphatases II 498-739 1.7e-16 56.3 In-house 40-280 (314) alignment
Range on Protein: 498-739
Range on HMM: 40-280/314.0
TAMLPHNLEKNVRRNTLlPYEyNRVLLAN-PGEKDQYYNASFIPTYspqMPIIVAEGPQRPTLTLF----------WQMM--WQQEVSLVAM--------
.| |. | .||   . | |.. ||| | . |..   |.|||.. ..   .  |...||   |.  |          |.|.  ... |  . |        
vadlflnrdknryldil.pad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------TTTISDGSqvvgerywpS---EGDILEIGplqitlehehtnlaicerslRVKHIDLGITRD-VKLLQMlFWVAgEACEDSHRFLAFA
              .... .          .   . |. ..                     .. . .   .|  .|.|..  .   . . ..  |..| 
elsrLdaAlgKtpllildgng.........neptaadlellk....................eelydpelferlgikylri.pvpD.gsaplledfdefl

ERVRDArsklKPDQPLLVHGITAVGRAGAFCALLNLLDRFdnerRLNVVDELTRLRQARS-----HFISDVVYLETILACVLDYA
| ...|    ... |.|||    .||.| |...  |. ..    .... . | ..|..|.     .||     .| || ..|.| 
efieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleyl

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 498-594 2.2e-07 24.8 In-house 90-180 (244) alignment
Range on Protein: 498-594
Range on HMM: 90-180/244.0
TAMLPHNLEKNvRRNTLLPYEYNRVLLANPGEKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTttisdGSQVVGERYWPS
 |. | |  || |  . ||...||| |..    . | ||||.         |... |   |   ||.|| .. | .. .      ||    . ||| 
dafnpnnswkn.regaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvl.....gsveeedeywpd

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 499-741 6.2e-38 125.5 In-house 36-278 (281) alignment
Range on Protein: 499-741
Range on HMM: 36-278/281.0
AMLPHNLEKNVRRNtLLPYEYNRVLLANPG--EKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSEG
.  ..| .||  .| .  |.  || ...    ..  | ||.|.|.|. .   |...||   .|. ||||.|.|.||...| |   .....   |||| . 
skadenvlknrYsn.ivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddn

DILEIGPLQITLEHEHTNLAICERSLRVkHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKlKPDQPLLVHGITAVGRAGAFCALLNLL
  |..| .... ..|...    || ... . . | ||.|. |. . |    . .... .| | . |. ...| | ..||..|  . |||.|.. ||  |.
selkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltek.ktkaplvihCsaGvGrtGtyialDrlv

DRFDNE-RRLNVVDELTRLRQARSHFISDVVYLETILACVLDYAAN
.. ..| ..|.| . .. ||..|  ..  ||  | .   |||.  .
kaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 500-741 1.2e-32 108.2 In-house 46-286 (297) alignment
Range on Protein: 500-741
Range on HMM: 46-286/297.0
MLPH-NLEKNVRRNtLLPYEYNRVLLANPGEK--DQYYNASFIPTYSPqmPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQvVGERYWPSEG
   . |.||.  .|  |||. .|| ||  ...    | ||||....     .|  . |.. |.  ||.|.....|| ..| .  ... .    |||. .|
aekkvnfeksRYkn.iLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg

dILEIGPLQITLEHEHTNLAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACE--DSHRFLAFAERVRDARSKLKPDqPLLVHGITAVGRAGAFCALLN
 . . | . ..|.  .      .|.| |.. .   .| ||  | . |   .  .  . . .| . . ||.  |. .   ||||| .. |||.| ......
.vttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrtgvlltids

LLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDYAAN
 . .  .|  ... . ...||| | ...      . .   ||..   
vvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 500-602 5.2e-13 43.5 In-house 29-133 (297) alignment
Range on Protein: 500-602
Range on HMM: 29-133/297.0
MLPHNLEKNVRRNtLLPYEYNRVLLANPGEKDQYYNASFI--PTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSE-G
  .  | ||  |. .| .. .|| | .   . .| || ..  |    ..  |.|.|| . |.  ||.....|.|  ..| . . .. .     ||||  .
krnsslrknryrd.ilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvq

DILEIG
. |. |
erlkag

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 501-727 4.6e-30 99.6 In-house 6-230 (250) alignment
Range on Protein: 501-727
Range on HMM: 6-230/250.0
LPHNLEKNvRRNTLLPYEYNRVLLANPG--EKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVvGERYWPSEGDi
 |.|.||| |   .....  ||.| .    ..  | ||||. .|. .   |.. ||  .|.  ||.|....... . | |....  ..  ..||| |.  
kpqnkekn.ryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka.

LEIGPLQITLEHEHTNLAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKpDQPLLVHGITAVGRAGAFCALLNLLDR
 . | ....|  ...   .  | | . .      | |. |. . |      |  .  |.. ..|.  . . . ..|..|.  . |||.|||.|.  .|.|
ekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqag.naPvivqCsaGvgrsGafiaidavler

FDNERRLNVVDELTRLRQARSHFISDVVY
  .|. ..| . . .||. | | .     
lkkekvvdvfkvikvlrkdrphavesleq

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 502-739 6.8e-35 115.4 In-house 45-278 (287) alignment
Range on Protein: 502-739
Range on HMM: 45-278/287.0
PHNLEKNvRRNTLLPYEYNRVLLAnpGEKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSEGDiLEI
..| .|| | . .|... .||||   ||...| ||.|| .|. .   |.||.|   |.  ||.......|. . | .   .  . |  .|||.|   . .
sqnkdkn.Rltqilvpdnyrvllk..gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvl

GPLQITLEHEHTNLAICERSLRVKHID-LGITRDVKLLQMLFWVA-GEACEDSHRFLAFAERVRDARSKlkPDQPLLVHGITAVGRAGAFCALLNLLDRF
|. .|.| .|..|    || |.||. .  | .. ||  |.  |   |.  |    .| . |...  | .   . ...||   .|||.. |||    ... 
GeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkr..gntsivvhCsdtvGrsamfcaaattinkc

DNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDYA
..|  ..|.. | . |. . . .  |   . |   || | 
kteGviDvfqvlksqriqkpgsvqtveqykfindivleyl

subfamily_Ptp69D_pd Subfamily Ptp69D 502-741 2.3e-33 110.7 In-house 46-288 (307) alignment
Range on Protein: 502-741
Range on HMM: 46-288/307.0
PHNLEKNvRRNTLLPYEYNRVLLAN--PGEKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSEgDIL
  |. || | . . ... .|| |..    |. .| ||||| .|  .   |.| .|   |.  ||.|...||| |. | . ... ..   ..||| | |. 
kenalkn.RyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.dev

EIGPLQITLEHEHTNLAICERSLRVKHID-----LGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLkpDQPLLVHGITAVGRAGAFCALLN
. | . ..| .|..     .|.| | ...     .  .| |   . . |   .. | ..  | . |.||.  ..     |..||  . |||.| | ||  
qygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..rsPivvhCsaGvgrsgifvalds

LLDRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDYAAN
||..  .| ......    ||. |. ..      . .   .|||   
llqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy

subfamily_CG7180_pd Subfamily CG7180 502-725 8.7e-31 101.6 In-house 40-276 (296) alignment
Range on Protein: 502-725
Range on HMM: 40-276/296.0
PHNLEKNvRRNTLLPYEYNRVLLAN-PG-EKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQvVGERYWPSEGdIL
 .|.||| |  . .||.||||.| .  | ||..| ||... ..  .   || |.|.. |.  ||......|.| | . |   | ..     ||| ..   
kenrekn.rdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.ke

EIGPLQITLEHEHTNLAICERSLRVKHI-------DLG---ITRDVKLLQMLFWVAGEACEDS-HRFLAFAERVRDARSKL---KPDQPLLVHGITAVGR
. |.. . . .|..  ..  | .....        . .    || |||.|.  |  .. .  |   .. . .|||  | |    .  .|..|.    ..|
qygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasR

AGAFCALLNLLDRFDNERRLNVVDELTRLRQARSHFISDV
.|...|.   |.  ..| ...| . . .||. | . .  |
sGvylaidanlelvekeeevdvFeavktlrrsRpqLvenv

subfamily_PTPN13_pd Subfamily PTPN13 503-722 1.3e-28 95.0 In-house 36-252 (273) alignment
Range on Protein: 503-722
Range on HMM: 36-252/273.0
HNLEKNVRRNtLLPYEYNRVLLANPGEkdqYYNASFIP--TYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSE-GDIL
.| .||  || .|||.  || | . |    | |||.|       .   |.. ||   | . ||||.|.|.....|| |.  .. .|  .||||.. .. |
enkdknryrn.vlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkkl

EIGP-LQITLEHEHTNLAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSklkPDQPLLVHGITAVGRAGAFCALLNLLDR
 .   |...|..     .   |.| ||... | .|.|  |..  |   .    .  .| |. .||  ..      |..||  . .||.|.. ..  .|. 
kvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPivvhcsaGiGrsGtlitidvvlgl

FDNERRLNVVDELTRLRQARSHFI
 .... ..| . . .||. |   .
ierdkefdvkeivrklreqrqgvv

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 503-723 1.1e-27 91.4 In-house 42-260 (515) alignment
Range on Protein: 503-723
Range on HMM: 42-260/515.0
HNLEKNVRRNtLLPYEYNRVLL--ANPGEKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPS-EGDIL
 | .||  .|  |||. .|| |   |   .  |.|||.||..  .   | . ||.. ..  ||....|..|. .|| |  ..| ..   .|||   || .
infkknrykn.ilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

EIGPLQITLEHEHTNLAICERSLRVKHIDLgiTRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKpdQPLLVHGITAVGRAGAFCALLNLLDRF
. | ... |   ..      | |.| . |   .| |   ..  |    . ...  .| .   |.  .....   ||..|  . |||.| .... . . . 
kfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsvvaha

DNERRLNVVDELTRLRQARSHFIS
 . | ..| . .| .|| | ... 
kttrmvdvfnfvtnirqkrpylvq

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 503-722 4.5e-16 53.7 In-house 31-242 (267) alignment
Range on Protein: 503-722
Range on HMM: 31-242/267.0
HNLEKNVRRNTLLPYEYNRVLLANPGEKdqYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSqvVgERYWPSE-GDILEI
.. ..  | .  |||. .|| | .  |   | |||.. .|  .   || ..| . | | |.... .|.|. . . |..  .   .  ..|| . |.  . 
eknqernrlddnlpyddtrvilrtkeee..yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn..i.rlfwPPkmgqakky

GPLQI--TLEHEHTNLAICERSLRVKHIDlgiTRDVKLLQMLFWVAGEaceDSHRFLAFAERVRDARSKLKPDQPLLVHGITAVGRAGAFCALLNLLDRF
  | .  .||.|  .  |    |..|      ...| |     |       . . .|     .       . ..||.|.    |||.|.|  .   |.| 
qdltvehslekeendyqiitlelkfknes...ahnvtlyyykkwnint...nnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlera

DNERRLNVVDELTRLRQARSHFI
 .|  ... | | ..|. |  ..
ktegvsdifdflrkirsqriglv

subfamily_ptpA1_pd Subfamily ptpA1 503-701 1.3e-12 42.2 In-house 46-258 (418) alignment
Range on Protein: 503-701
Range on HMM: 46-258/418.0
HNLEKNvRRNTLLPYEYNRVLLANPGEK--DQYYNASFIPTYSPQMpIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSE--GDI
||  || |   .|| .. || | .  .|   .| || .|    |.  .|...||   |.. ||.|.|.. . .. | .  |.  ..  .|||| .  |. 
hntskn.rytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeq

LEIG-P---LQITLEHEHTN-LAICERSLRVKHIDL---GITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKPD----QPLLVHGITAVGRA
. |      .  |   |  . .   || .  . | |   | |||.   |   |   .  . .. |  .   . . . .. |      |..||  . |||.
fsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrt

GAFCALLNLLDRFDN
|.||. . .. ..| 
gtfctavimmkkldh

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 503-725 2.4e-12 41.5 In-house 40-263 (307) alignment
Range on Protein: 503-725
Range on HMM: 40-263/307.0
HNLEKNvRRNTLLPYEYNRVLLANPGEKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSE-GDILEI
 | .|| | . .   . .|...  .|   .|  | .. .      .|.|.||.  |   || |. |..|  | |   . . ...  |.||| | |. |  
antdkn.ryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvf

G--PLQITLEH-EHTNLAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKlkpDQPLLVHGITAVGRAGAFCALLNLLDR
|  |  |...     .||  |  . |  ...  ... . .| | |         .  |.  . .   | .     |..||  . |||.|.  |.  . |.
geapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd...tnpvvvhcsaGvGrsGtivaislvqdk

FDNERRLNVVDELT-RLRQARSHFISDV
  .      ...|   ||. | . | . 
miaGinckdmkklveelrsqrhyaiqte

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 505-720 2.8e-20 67.5 In-house 4-220 (237) alignment
Range on Protein: 505-720
Range on HMM: 4-220/237.0
LEKNvRRNTLLPYEYNRVLLANPGEKDQYYNASFIPTYSPQ-MPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSEGDILEIGP
  || |   .  |...||.|  .| . .| ||...  .       | |.||  ..   ||||.||.  |.. | | . .| ..   .||||  .    | 
kikn.rygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygv

LQITLEHEHTNLAICERSLRV-KHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKPDQPLLVHGITAVGRAGAFCALLNLLDRFDNE
| ..| ..        ||| . |.. |   | ..  |.  |      . .  .| |  .. .   ..    | ..|  ..|||.| |  .  .| .  ..
ltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakek

RRLNVVDELTRLRQARSH
. ... . .  . . | .
kvvdiynyvysieedrpy

Y_phosphatase Protein-tyrosine phosphatase 506-736 6.5e-43 142.2 Pfam-A 3-234 (235) alignment
Range on Protein: 506-736
Range on HMM: 3-234/235.0
EKNvRRNTLLPYEYNRVLLANPGEKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWP-SEGDILEIGPL
.|| | .. |||. .|| | . ... .|.||... .|. .  .|...||   |.  ||.|.||..|....| |.  . ...  ..||| .|.. |. | .
kkn.RykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

QITLE-HEH-TNLAICERSLRVKHIDLGI-TRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARskLKPDQPLLVHGITAVGRAGAFCALLNLLDRFDN
...|. .|.  . ... | |..|. .    .| || |..  |   .. |... .| . ..|.  .   . ..|..|| .. |||.| |.||  ||.....
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleqlea

ERRLNVVDELTRLRQARSHFISDVVYLETILACVL
|. ..|.. . .||. | . ....  .. . ...|
eeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 506-736 6.5e-43 142.2 In-house 3-234 (235) alignment
Range on Protein: 506-736
Range on HMM: 3-234/235.0
EKNvRRNTLLPYEYNRVLLANPGEKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWP-SEGDILEIGPL
.|| | .. |||. .|| | . ... .|.||... .|. .  .|...||   |.  ||.|.||..|....| |.  . ...  ..||| .|.. |. | .
kkn.RykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

QITLE-HEH-TNLAICERSLRVKHIDLGI-TRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARskLKPDQPLLVHGITAVGRAGAFCALLNLLDRFDN
...|. .|.  . ... | |..|. .    .| || |..  |   .. |... .| . ..|.  .   . ..|..|| .. |||.| |.||  ||.....
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleqlea

ERRLNVVDELTRLRQARSHFISDVVYLETILACVL
|. ..|.. . .||. | . ....  .. . ...|
eeevdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 506-737 9.9e-26 85.3 In-house 34-264 (283) alignment
Range on Protein: 506-737
Range on HMM: 34-264/283.0
EKNVRRNTLLPYEYNRVLLANpgEKDQYYNASFIP---TYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSEGDIlEIG
..  | . ..|.. .|| | .  |  .| ||.|||    |  .   |.| .| . |   ||.|....... . | | . .. ..   .|||..| . . |
krknrnqeivpadqwrvelks..esrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGse.dyG

PLQITLEHEHTNLAICERSLRVKHI-DLGITRDVKLLQMLFWVAGEACEDSHRFLAFaERVRDARSKlKPDQPLLVHGITAVGRAGAFCALLNLLDRFDN
.. .||..| |. .   . | ...      |  .   |.  |.  .       .. | ..|.  . . ... |..||  |..||...|.|.   ..    
eftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf.nkvislqte.skkgPivvhCstgiGrtavfiaasasvkdalt

ERRLNVVDELTRLRQARSHFISDVVYLETILACVLD
|  ..|   .. .|. |   .        .   ||.
esvvdvfavvkimreqrmmavqtldqyklvhelvle

subfamily_eak_pd Subfamily eak 507-626 1.1e-06 22.3 In-house 51-174 (332) alignment
Range on Protein: 507-626
Range on HMM: 51-174/332.0
KNVRRN--TLLPYEYNRVLLANP-GEKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVS-LVAMTTTISDGSQvVGERYWPSEG-DILEI
..|.||   ..||... | |..   ... | ||| .         |..  ..   . .||||. .|    .| .   .  . .   ..|.| .. . |. 
eavnrnvvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkle.ksdkyfpdktreelkf

GPLQITLEHEHTNLAICERSLRVKH
| |...  .   .  .  | | .. 
Gildverkefvkrniletrllelsk

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 509-724 2.4e-31 104.0 In-house 50-268 (305) alignment
Range on Protein: 509-724
Range on HMM: 50-268/305.0
VRRNTLLPYEYNRVLLANPGEKD--QYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSE-GDILEIGPLQ
 | .   ... .|. |..  ..|  .| |||.. .|. .   ||| || . |.. ||.....  || . | | . .| .   ..||| . ..  |.|...
nrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefs

ITLEHEHTNLAICERSLRVKHID-LGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKpDQPLLVHGITAVGRAGAFCALLNLLDRFDNERR
..|. |.|     || |..   |    .| |  .|.  |      . .  .| . .||. ...| | ..|||||   .|||.|.|.|.   |.|  .|  
velksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdk.gvpllVhCsagvgRtGvfiavdialerlkkEev

LNVVDELTRLRQARSHFISD
..| . | .||. |   .. 
vdvfevlkqlRskrmkmvqt

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 509-742 1.3e-26 88.2 In-house 24-267 (270) alignment
Range on Protein: 509-742
Range on HMM: 24-267/270.0
VRRNTLLPYEYNRVLLANPGE--KDQYYNASFIPTYS-PQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSEGDI---LEIG
 | . .||    || |..  |  . .|.|| ... ..  .   | | ||.  ||. ||.|.|...|. ..||| . .  .   |||||.| .    || |
nRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledg

PLQITLEHEHTNLAICERSLRVKhiDLGITRDVKLLQMLFWVAGEA------CEDSHRFLAFAERVRDARSKLKPDQPLLVHGITAVGRAGAFCALLNLL
 .... ..|. .     . ||..  . | .| .   ..  |    .        ...  |.  . ||  ...|.  .|||||    |||.| . ||   .
kikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiav

DRFDNERRLNVVDELTRLRQARSHFISDVVYLETILACVLDYAANK
   .......|.  ...||. |  ... ..  | . . |. ||  .
rlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr

0041856 (Phosphotyrosine protein) phosphatases II 510-723 6.2e-18 60.5 In-house 6-155 (182) alignment
Range on Protein: 510-723
Range on HMM: 6-155/182.0
RRNTLLPYEYNRvllanpgeKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTtisdgsqvvGERYWPSEGdileigplqitle
|    |||...|           | ||...  . |.. .|.. ||   |.  |..|.... .... . |         .|.|||..              
rysdilpydhsr........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell.............

hehtnlaicerslrvkhidlgiTRDVKLLQMLFWVAGEACEdSHRFLAFAERVRDarsklkPDQPLLVHGITAVGRAGAFCALLNLLDRfdnerRLNVVD
                      .| .  .. |.|  .....  . .|.| |.|..      .. | |||    |||.|...|.  .. .     .... .
......................erlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvslee

ELTRLRQARSHFIS
 .  .|..|.. . 
avklvrsrRpgmvi

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 510-724 4.3e-14 47.3 In-house 13-226 (239) alignment
Range on Protein: 510-724
Range on HMM: 13-226/239.0
RRNTLLPYEYNRVLLANPG--EKDQYYNASFIPTYSPQM-PIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSEGDilEIGPLQI
|   .. |...||.| .     . .| |||..  |       | ..|   ..   ||.||||.   .. | | . .| .    .|||      .   |..
ryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..kycnlrv

TLEHEHTNLAICERSLRVKHIdlGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKPDQPLLVHGITAVGRAGAFCALLNLLDRFDNERRLN
|| .         |.. . ..  | | .  . |  | |  .     .    .  | . ..  |   .| ..|  . |||.|||  .  .| .  ... ..
tlrktevfadyiirtfvmsqv..gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvd

VVDELTRLRQARSHFISD
... .  .|. | |..  
ifnyvkairedrphmvqt

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 510-724 4.4e-14 47.2 In-house 12-225 (239) alignment
Range on Protein: 510-724
Range on HMM: 12-225/239.0
RRNTLLPYEYNRVLLANPG--EKDQYYNASFIPTYSPQM-PIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSEGDilEIGPLQI
|   .. |...||.| .     . .| |||..  |       | ..|   ..   ||.||||.   .. | | . .| .    .|||      .   |..
ryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..kycnlrv

TLEHEHTNLAICERSLRVKHIdlGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKPDQPLLVHGITAVGRAGAFCALLNLLDRFDNERRLN
|| .         |.. . ..  | | .  . |  | |  .     .    .  | . ..  |   .| ..|  . |||.|||  .  .| .  ... ..
tlrktevfadyiirtfvmsqv..gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvd

VVDELTRLRQARSHFISD
... .  .|. | |..  
ifnyvkairedrphmvqt

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 512-718 2.9e-17 57.3 In-house 47-272 (301) alignment
Range on Protein: 512-718
Range on HMM: 47-272/301.0
NTLLPYEYNRVLLANPGE----KDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPS-EGDILEIGPLQI
.   .|. ||..|..  .    . .| |||.|  || .   |.|.|| . ||. ||...||. .. . | |   .|..   |.|||. | .  | ||...
knitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftv

TLEHEHTNLAIC-----------------ERSLRVKHIDlgITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKpDQPLLVHGITAVGRAGAF
|| .|..                      ||...||.     ..||  ||.  |       . .  |   . |  .. |     |..||   .|.|.| .
tlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkig.ggpvvVHCSdtVsrsGvY

CALLNLLDRFDNERRLNVVDELTRLRQAR
|..   |.    |   .|..   ..|. .
csvsiglEQckaegVVdvfqvtkavrrsk

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 514-729 1.3e-07 25.6 In-house 56-269 (303) alignment
Range on Protein: 514-729
Range on HMM: 56-269/303.0
LLPYEYNRVLLANpgekDQYYNASFIPTYSpQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSEGDILEIGPLQITLEhEHT
..  .. .| |..      |  ||..   | .   |... |   | . ||||. .| |  | .  | |.  .. |.  .| . |.|..    | .  |  
vicldhskvklsd....ssyihasylelds.skkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvg.efk

NLAICE-RSLRVKHIDLGITRD-VKLLQMLFWVAGEACED-SHRFLAFAERVRDARSKLKPDQPLLVHGITAVGRAGAFCALLN-LLDRFDNERRLNVVD
.. . .  .|.|  .  |  .  ... .   |  ..   | | .|.    ...    |  . .| .   .. .||||.|. .    |   ...  |..| 
rvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvk

ELTRLRQARSHFISDVVYLE
 |  .|. | | . ..  . 
clenvrngrlhavqnlsqfs

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 515-740 1.1e-15 52.0 In-house 66-284 (290) alignment
Range on Protein: 515-740
Range on HMM: 66-284/290.0
LPYEYNRVLLANpGEKDQYYNASFIPTYSPqmPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWP-SEGDILEIGPLQITLEHEHT
   .  ||.| . | . .|  | ..    .  ..|...|. . |   .|.|. |..|. . |   . .  .   |.|.|  ||..| .| . ..   |..
vcndktrvilkd.GydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseedd

N-LAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDShrfLAFAERVRDARsklKPDQPLLVHGITAVGRAGAFCALLNLLDRFDNERRLNVVDELT
.   |  . | |.. | |    .| |..  |        .   ||.   .|  |   |   |. ||  . .||.|.| |.   |. . . . |...|   
kdaniikktlsvrdkdsGkehklkhlkikswpdksvalst...lallrtlrilr...kasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvr

RLRQARSHFIS-DVVYLEtILACVLDYAA
 ||..|   .  |. ||  ..  .||.  
alrnsrlnsvqvdiqyla.lveilldlGk

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 517-744 1.7e-08 28.5 In-house 67-294 (305) alignment
Range on Protein: 517-744
Range on HMM: 67-294/305.0
YEYNRVLLANPGeKDQYYNASFIPT-YSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPS-EGDILEIGPLQITLEHEHTN
 . . |.|..|    .|  | ..     |.  .|.|.||   |.  || |. |. |  . |     .  ..   .|||   |. ||.    .  .   ..
qdqsavkldkps.psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgsk

LAICERSLRVKHIDLGITRDVKL-LQMLFWVAGEACEDSHRFLAFAERVRDARSKLkpdQPLLVHGITAVGRAGAFCALLNLLDRFDNERRLNVVDELT-
    .  ...  ..|  . | |. .. | |            |.  | .   |       |..||  . .||.|.  |.  .|..  ....   . ||  
pmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk...vpivvhcsagigrtgtivaieyilekiaenkpcppmpelvk

RLRQARSHFIS-DVVYLeTILACVLDYAANKDK
 ||. |.. |  || ||  |   .|.|  .| |
alrdqrafsiqndvqyl.fihrvmlnyflekyk

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 517-742 1e-07 25.7 In-house 63-288 (302) alignment
Range on Protein: 517-742
Range on HMM: 63-288/302.0
YEYNRVllANPGEKDQYYNASFIPTYSPQMPIIVAEGPQRPTL---TLFWQMMWQQEVSLVAMTTTISDGSQvVGERYWP-SEGDILEIGPLQITLEH-E
.. |.|   ...|.|.|.||| .   . . .||.|  |.. .      ||.|..|...  | .     . ..   . ..|   || .| | . .     |
ldsnlv..kleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVe

HTNLAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVrdARSKLKPDQPLLVHGITAVGRAGAFCALLNLLDRFDNERRLNVVDEL
... .  . .. |   .   .  ...  . .| . .  .   .  . |. |    .| | |.....     .|||||| .|   ... ...   |. . .
kaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv..fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeiv

TRLRQARSHFISDVVYLETILACVLDYAANK
. .|. |.. .  .    ..  ..| |  .|
ksiRsqRpravdslkQyvslyialllyikkk

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 518-721 1.3e-10 35.8 In-house 48-252 (285) alignment
Range on Protein: 518-721
Range on HMM: 48-252/285.0
EYNRVLLANpgEKDQYYNASFIPTY-SPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSE-GDILEIGPLQITLEH--EHT
|  ||.| |     .|  ||..      |   | ..||   ||. ||.|..|.... | |  |. .|       |.| . |.....|  .|||    | .
eetrvvlkn..hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeea

NLAICERSLRVKHIDLGITRDV--KLLQMLFWVAGEACEDSHRFLAFAERVRDARSKlkpDQPLLVHGITAVGRAGAFCALLNLLDRFDNERRLNVVDEL
       .| |   .   .  .  . .|. .|    | ||.. .. . . |.    |   ..|. ||  . |||. .|  .     |  ..  ....| .
iagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk...ekpicvhcsagvgrtatfvgidyatirimenpniemldiv

TRLRQARSHF
  .|  | . 
remramrfqa

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 519-739 1e-09 32.9 In-house 57-271 (288) alignment
Range on Protein: 519-739
Range on HMM: 57-271/288.0
YNRVLLAnpGEKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSE-GDILEIGPLQITLEHEHTNLAI
. || |    . | | .|  ...   .  .| |. | . |.  .|.|. ...|  . | . . .  .   . |.||. |.   || |     ......  
itrvkls..ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidk

CERSLRVKHIDLGITRD-VKLLQMLFWVAGEACEDSHRFLAFAERVrdaRSKlkpDQPLLVHGITAVGRAGAFCALLNLLDRFDNERRLNVVDELTRLRQ
  .   ..    | ..  || | .| |      |.   .| . |..   .|    ..|..||  . |||.|..   |  |.    .  | .   |..||.
lvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl...ksl...qkPivvhssaGvGrtgtlililialeslrlddflgirsllaklre

ARSHFISDVVYLETILACVLDYA
 | . |        .  |||.. 
erfkaiqtemqylyvhrcvleel

subfamily_CG42327_pd Subfamily CG42327 519-657 3.1e-08 27.6 In-house 42-185 (319) alignment
Range on Protein: 519-657
Range on HMM: 42-185/319.0
YNRVLLANPG--EKDQYYNASFIPTYS-PQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSEG---DILEIGPLQITLEHEH
  || | . |  .||.| .||..  |   .   | |. .   . . ||...|.|    .   | .|.    |  .|.|..    .    | ...|| .  
etrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgre

TNLAICERSLRVKHIDLGITRDVKLLQMlFWVAGEACEDSHRFLA
..      .| .|..|   .|..       |.  |   .   ..|
vkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaalia

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 521-742 2.4e-06 21.5 In-house 59-279 (312) alignment
Range on Protein: 521-742
Range on HMM: 59-279/312.0
RVLLAnpGEKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQ-EVSLVAMTTTISDGSQVVGeRYWPSEGDILEIGPLQITLEHeHTNLAICE
|  ||  |... |  | |.   .    .....||   | | |||.      .|.. ... . |||. .  .|      ....   ..  |.  |.. |  
rftla..gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekca.kyisdivgfvdledhrvytey.cteieigg

RS--------LRVKHIDLGITRDVKLLQMLFWVA---GEACEDSHRFLAfaervrdARSklKPDQPLLVHGITAVGRAGAFCALLNLLDRFDNERRLNVV
.|        |.|     |    ..  |   |      ..|. ..|.|.       |    |  .|.. |  . |||.|... .  ..  .   |. || 
kskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrlls.......avk..kdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvk

DELTRLRQARSHFISDVVYLETILACVLDYAANK
| .  ||. |.  .  .      | |||..  .|
dsfvllrkdrarsvrvfpqyvyalrcvleflysk

0043147 (Phosphotyrosine protein) phosphatases II 529-727 2.4e-17 58.7 In-house 3-149 (172) alignment
Range on Protein: 529-727
Range on HMM: 3-149/172.0
EKDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTIsdgsqvvgerywpsegdileigplqitlehehtnlaicerslrvKHID
| . |.|||....|   . .|.  || | ||  ||.|.... .... . |.                                              .. 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp

LGITRDVKLLQMLFWVAGEACeDSHRFLAFAERVRDARsKLKPDQPLLVHGITAVGRAGAFCALLNLLdrfdneRRLNVVDELTRLRQARSHFISDVVY
 . .| .  .. | |  . .. ..  .| | | ....   |.|. | |||    |||.|...|.. .|      ..|.. . .  .|..|.. .    .
ellerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsq

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 530-693 7.4e-07 23.1 In-house 65-221 (281) alignment
Range on Protein: 530-693
Range on HMM: 65-221/281.0
KDQYYNASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSEGD-ILEIGPLQITLEHEHTNLAICERSLRVKHid
  .|  | .| .   .   |...||.. | . ||.|.||.. . . |   . .  .     |.| .    |..  | .. |    | ..    | . .  
stdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsy..

LGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRdARSklkpdQPLLVHGITAVGRAGAFCALL
 | || .       |   .  | |  .|    ..| |||      | ..|  . |||.|.. |. 
egetrlithwlwkewpdwqvpessevmlkilrkir.ars.....tppvihcsagvgrsgtlmave

0051429 (Phosphotyrosine protein) phosphatases II 531-739 4.2e-19 64.7 In-house 4-225 (272) alignment
Range on Protein: 531-739
Range on HMM: 4-225/272.0
DQYYNASFIPTYspqMP------IIVAEGPQRPTLTLFWQMmWQQEVSLVAMTTTISDGSQVVGERYWP-----------SEGDILEIGPLQITLEHEHT
. |.||.....|           .. . || . |   ||.. ... .. . . .. .   ..  .||||           ..    ..| | .|| .|..
sgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

NLAICERSLRVKHI-DLGITRDVKLLQMLFWVAGEACEDShrFLAFAERVRDarsklkpDQPLLVHGITAVGRAGAFCALLNLLDRFDNERRLN------
 | .  | |..... . | .| | .|... |.   .....  .|.. | ..|       ..|.|||    ..| | ..||| || ... |  ..      
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--VVDELTRLRQARSHFISDVVYLETILACVLDYA
  . . . .||..| ... .   .. .. ..|...
lyleeaveelraqrpgavqteeqylflyeallell

0036282 (Phosphotyrosine protein) phosphatases II 531-727 1.6e-17 59.2 In-house 2-158 (174) alignment
Range on Protein: 531-727
Range on HMM: 2-158/174.0
DQYYNASFIPTYSPQMPIIVAEGPQRptltlFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSegdileigplqitlehehtnlaicerslrvkhIDLG
. |.|||..  .     .|.  || .     ||.|.... .. | | ..      .   .|||.                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

ITRDVKLLQMLFWVAGEACEDSHrFLAFAERVRDARSKlKPDQPLLVHGITAVGRAGAFCALLNLLDRFDnERRLNVVDELTRLRQARSHFISDVVY
 .| .  .. | |. ... ..|  .| | ..|..|.|. .|. |.|||    |||.|...|.. .| .   |.  ...| . .||. |.. .    .
lerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

0046846 (Phosphotyrosine protein) phosphatases II 531-733 9.3e-13 43.8 In-house 12-167 (176) alignment
Range on Protein: 531-733
Range on HMM: 12-167/176.0
DQYYNASFIPTYSpqmpIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSegdIL---Eigplqitlehehtnlaicerslrvkhi
  | ||..| ..      |.  || . ||  |..|.... ...| . |.  . ...   .|||    .                                
ldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi...........................

dlgitrdvkLLQMLFWVAGEACEDsHRFLAFAERVRDARSKlkpDQPLLVHGITAVGRAGAFCALLnL-LDrfdnERRLNVVDELTRLRQARS-HFISDV
           . | |. . ....   .| . | .|.|...   ..| |||    .||.|...|.. |       |. |.| . | ..|. |. . .   
.........qylhlpwpDhgvpdl.elllellefirealke...ggpvlVHCsaGigRtgtlvaay.llel....ekglsveealalvreqRplgavqtp

VYLETILA
 ... .  
eQyrflye

0044763 (Phosphotyrosine protein) phosphatases II 531-726 2.2e-09 32.7 In-house 18-158 (178) alignment
Range on Protein: 531-726
Range on HMM: 18-158/178.0
DQYYNASFIPTYspqmpIIVAEGPQrptlTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSEGDileigplqitlehehtnlaicerslrvkhidlg
 .|.|||.|  .     ....  |.      ........ .... . |.   . ..   .|||.| .                                 
sdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.................................

itrdvKLLQMLFWVAGEACEDSHRFLAFAERVRDARSklKPDQPLLVHGITAVGRAGAFCALLNLLDRfdnerRLNVVDELTRLRQARShFISDVV
        . . .. . ... .  ||.| | ...|..  ... | |||    |||.|...|.  .. .     .|.. . . ..|..|. ..    
.....iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpg

0051082 (Phosphotyrosine protein) phosphatases II 531-723 2.2e-09 32.6 In-house 3-137 (151) alignment
Range on Protein: 531-723
Range on HMM: 3-137/151.0
DQYYNASFIPTYspqmpIIVAEGPqrptLTLFWQMMWQQEVSLVAMTTTISDGSqvVGERYWPSEGdileigplqitlehehtnlaicerslrvkhidlg
. |.|.|..  .     ...  ||    |  |....... .. . . ..          .|.|..|                                  
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg..................................

itRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDarsklKPDQPLLVHGITAVGRAGAFCALLNLLDRfdnerrLNVVDELTRLRQARSHFIS
  ..|. ...| | .    .  . .|.| | ..|     |...|.|||    .|| |...||. .| .      ... . |  .|. | ... 
..ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvq

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 535-723 3.3e-11 37.5 In-house 79-265 (301) alignment
Range on Protein: 535-723
Range on HMM: 79-265/301.0
NASFIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSE-GDILEIGPLQITLEHEHTNL--AICERSLRVKHIDLG-
 | .|||       |.. || . |   || |. | .|  ..| .   .  . . | | |.. .. |.||  .|....... |   | .|.|.|.      
hanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkf

ITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRdarsklKPDQPLLVHGITAVGRAGAFCALLNLLDRFDNERRLNVVDELTRLRQARSHFIS
 || |   |   | . .  .       . | |.      | ..|..||  . .||. || .   |  . ........ . | .||. | . . 
atrtvthyqysewtdrgvPkshaelfdlmelvk......ksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvq

0049260 (Phosphotyrosine protein) phosphatases II 538-726 4.2e-15 51.2 In-house 1-137 (152) alignment
Range on Protein: 538-726
Range on HMM: 1-137/152.0
FIPTYSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWpsegdileigplqitlehehtnlaicerslrvkhidlgitrdvkL
||. | .....| ..|| . ||  ||.|.... .. . | |. ..   .  |.|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

LQMLFWVAGEACEDSHRFLAFAERVRDArsKLKPDQPLLVHGITAVGRAGAFCALLNLLdrfdneRRLNVVDELTRLRQARSHFISDVV
 . |.|  . ....|  .| . . .. .  .|... | |||    |||.|...|.. .|      ..... . . ..|..|.. .    
ylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpg

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 542-724 1.1e-07 25.5 In-house 232-423 (440) alignment
Range on Protein: 542-724
Range on HMM: 232-423/440.0
YSPQMPIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVgerYWPSEGDILEIGPLQITLEHEHTNLAICERSLRVKHI-DLGITRDVKLLQM
|| .  .| .. |   |.  ||... . ..| . |   . | .  .   ||| .   . .||. .          .  |.| .|.  ..   |. ..   
yskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsi...ywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevqtw

LFWVA------GEACEDSH-RFLAFAERVRDARS----KLKPDQPLLVHGITAVGRAGAFCALLNLLDRFDNERRLNVVDELTRLRQARSHFISD
  |.        | | |.  ... . ...   ||    .     |.||| .. .  .| ||...| |....|.  ..| ..|  || .|  |.  
ptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvpt

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 547-728 4e-08 27.7 In-house 6-193 (199) alignment
Range on Protein: 547-728
Range on HMM: 6-193/199.0
PIIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPS-EGDILEIGPLQITLEHEHT--NLAICERSLRVKHIDLGITRDVKLLQMLFW
  |... | | |.. ||||.|.     . |        ..    |||. |    . | | .| .   |  . .|.   |  .      ||..   |.  |
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

VAgEACEDSHRFLAFAERVRDARSKL--KPDQPLLVHGITAVGRAGAFCALlNLLDRFDNERRLNVVDEL---TRLRQARSHFISDVVYL
    .  .   |. |    |.   |   . | |..||     | .| | || ..  |  .| .  ||| .    ||||||   || . . 
ke.kttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfval.digvrsheesktsvvdlfevakrlrqarcgiisslqhy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 548-728 4.8e-08 27.4 In-house 6-192 (198) alignment
Range on Protein: 548-728
Range on HMM: 6-192/198.0
IIVAEGPQRPTLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPS-EGDILEIGPLQITLEHEHT--NLAICERSLRVKHIDLGITRDVKLLQMLFWV
 |... | | ||. ||||.|.     . |        ..    |||. |    . | | .| .   |  . .|.   |  .      ||..   |.  | 
yiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswk

AgEACEDSHRFLAFAERVRDARSKL--KPDQPLLVHGITAVGRAGAFCALlNLLDRFDNERRLNVVDEL---TRLRQARSHFISDVVYL
   .  .   |. |    |.   |   . | |..||     | .| | || ..  |  .| .  ||| .    ||||||   || . . 
e.kttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfval.digvrsheesktsvvdlfevakrlrqarcgiisslqhy

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 558-739 9e-08 26.5 In-house 40-221 (255) alignment
Range on Protein: 558-739
Range on HMM: 40-221/255.0
TLTLFWQMMWQQEVSLVAMTTTISDGSQVVGERYWPSEGDI-LEIGPLQITLEHEHTNLAICERSLRVKHIDLGITRDVKLLQMLFWVAGEACEDSHRFL
|.  |.|.. |.. . |.| .   . ...  ..|.| | |  | .  ...|  .  ..  .  . .  .  .   |..||  .   |..  | |...  |
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

AFAERVRDARSklkpdqpLLVHGITAVGRAGAFCALLNLLD----RFD--NERRLNVVDELTRLRQARSHFISDVVYLETILACVLDYA
     |||..|       ..||  | .||. ||     .       .|  .   |. .  |. ||. |.  | . ..|   .  |||. 
nilkvvrdsks.......vvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv

0048179 (Phosphotyrosine protein) phosphatases II 625-727 5.7e-07 24.9 In-house 39-133 (144) alignment
Range on Protein: 625-727
Range on HMM: 39-133/144.0
KHIDLGITRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSklkPDQPLLVHGITAVGRAGAFCALLNLLdrfdnERRLNVVDELTRLRQARSHFISD
..     .| .  .. | |   .. .... .|.| | ...|..   .. | |||    |||.|...|.  ..     ...|.. . | ..|..|.. .  
eyepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpn

VVY
  .
pgq

0048076 (Phosphotyrosine protein) phosphatases II 632-732 4.3e-07 25.2 In-house 44-136 (145) alignment
Range on Protein: 632-732
Range on HMM: 44-136/145.0
TRDVKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKlkpDQPLLVHGITAVGRAGAFCALLNLLDrfdneRRLNVVDELTRLRQARSHFISDVVYLETI
.| .  .. | |   .. ...  .|.| | ...|...   . | |||    |||.|...|.  .|      ..... . | ..|..|....  . .|. .
erlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrfl

L
.
y

PTPc_DSPc_SM00012 635-736 3.2e-10 35.5 In-house 2-104 (105) alignment
Range on Protein: 635-736
Range on HMM: 2-104/105.0
VKLLQMLFWVAGEACEDSHRFLAFAERVRDARSKLKPDQPLLVHGITAVGRAGAFCALLNLLDRFDNE-RRLNVVDELTRLRQARSHFISDVVYLETILA
|| .... |   .. |.|. .| . . |.. ..| .  .|..||  . |||.| |.||  ||.....| ..... . . .||. |.. ..       ...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CVL
..|
all