Gene MbrePTP-Un-8 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP062_AA protein Get Run
MbreP062_AA_73-351 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 72-350 6.7e-90 296.8 In-house 25-299 (308) alignment
Range on Protein: 72-350
Range on HMM: 25-299/308.0
RSRPMDVLALHEALRDREMLEEEFERAPHMLVGPD-TLPNDPRVAMKNRYTNILPTPATRVPLsqigpDALSTYMNANFVDGY--NQPKEFIATQGPKPE
. . .|.| |.| . |. .||||||. ... . .. .  . |.   ||||..|||   .|| |     |  |.| ||..||||  ..|..|||||||.|.
klsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpn

TVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTE-APLDTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEV
||.||||||||....|.||.| . | ||.||..|||. ..  .|   .|.. . |.|....|....|.|..  .| .| | ||..|||||||||... ..
tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeil

IDLVKAVRRARtdRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPhRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
.|....||. .  .  | |||||||.||||||.|.|. .. |.   . ||||. . |||.|| |..||. ||||...|. .|.
ldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleyl

0039614 (Phosphotyrosine protein) phosphatases II 74-350 7.5e-81 267.1 In-house 17-289 (297) alignment
Range on Protein: 74-350
Range on HMM: 17-289/297.0
RPMDVLALHEALRDREMLEEEFERAPHMLVGpDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGP-DALSTYMNANFVDGYNQ-PKEFIATQGPKPETVD
. .|.| |.| . .. .|..|||. . . .   .  . |    ||||..||| . .|| |. ..  |  |.| ||..||||.. ...||||||| ||||.
svldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetve

DFWRMVWEYRSEVVVMMTGIREGGRiKCHRYWPEHTEaplDTQNFQISIASTENMKHYILTKLTLEHraSGATRAVSHFWFTNWPDHGVPHETWEVIDLV
||||||||....|.||.|   | || ||..|||| ..      .|..   ..|  ..|....|....  .| .| | ||..|.|||||||. .  .....
dFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllefl

KAVRRARTD--RALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPhRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
..||.|.    .  | .||||||.||||||.| .. .. |.   . |||.  . .|| ||.|..||. || |...|.....
elvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallell

0045450 (Phosphotyrosine protein) phosphatases II 74-350 1.4e-80 266.6 In-house 12-304 (307) alignment
Range on Protein: 74-350
Range on HMM: 12-304/307.0
RPMDVLALHEALRDREMLEEEFERAPHMLV---GPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPD-ALSTYMNANFV--------DGYNQPKEFIA
.... | | . | ... |..|||. ... |   |. .  . |    ||||..||| . ||| || ....   | | ||..|        |||.....|||
lkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIa

TQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHtEAPLDTQNFQISIASTENMKHYILTKLTLEHR-ASGATRAVSHFWFTNWPDHGV
||||.||||.|||||.||....|.||.|.  | ||.||..|||.  . .|   ||..   |.| ...|....|....   .| .| | ||..|.||||||
tqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgv

PHETWEVIDLVKAVRRARTD--RALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHRV--VDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
|  . |..|....||.|. .  .  | .||||||.||||||.| .. .| |.. . .  ||..  . .|| ||.|..|.. || |...|.....
ppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 80-351 4.7e-58 191.7 In-house 17-285 (297) alignment
Range on Protein: 80-351
Range on HMM: 17-285/297.0
ALHEALRDREMLEEEFERAPHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQpkEFIATQGPKPETVDDFWRMVWE
.| .  |. .. .|||   |.  . |.|  ..     |.||.||||.   || |  .. |  | |.|| || |...  ..|.|| |...||.|||.||..
tlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvld

YRSEVVVMMTGIREGGRiKCHRYWPEHTEAPldTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPH--ETWEVIDLVKAVRRA
..  ..||..   |. . || |||.... ..    .  . . |... . .|  .|.... .. |.| |  . |..|||. |..  ..  ...|.. ||  
eqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkd

RTDRAL-PAVVHCSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
  ..|  | .|||.||.|||| .|..|  .   .. .  ||.|| . ||| .|   .||  || ||..|. ... 
fsqnaegPllvhclaGvGrtgvlltidsvvaeakr.ekevdifglvkklrqerpylvqtkeqykfvyvavleall

0036941 (Phosphotyrosine protein) phosphatases II 81-350 1.8e-84 278.9 In-house 5-277 (297) alignment
Range on Protein: 81-350
Range on HMM: 5-277/297.0
LHEALRDREMLEEEFERAPHMLVGPD-TLPNDPRVAMKNRYTNILPTPATRVPLsqigPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWE
| | | .. .|..|||. ...|. .. .  . |.   ||||..||| . ||| |    .|  | | ||..||||.....|||||||.|.||.||||||||
llekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

YRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQNFQISIASTEN--MKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRA
....|.||.|   | ||.||..|||. .. .|   .|..   |.|    ..|.|..|....  .| .| | ||..|.|||||||. . ...|....||..
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkv

RTD--RALPAVVHCSAGIGRTGTFLAVDMGIRSLNN--PHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
.    .  | .||||||.||.|||.|.|. .. |..   .. ||..  . |||.|| |..||. ||.|...|. ...
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

subfamily_PTPN14_pd Subfamily PTPN14 81-350 8.6e-57 187.4 In-house 16-296 (300) alignment
Range on Protein: 81-350
Range on HMM: 16-296/300.0
LHEALRDReMLEEEFERAPHMLVGPDTL-PNDPRVAMKNRYTNILPTPATRVPLSQIGpDALSTYMNANFVDGY--NQPKEFIATQGPKPETVDDFWRMV
|.. |..  ..  |.|| |..    ..   . |  | |||. ..||   .|| ||    .. . |.||  .      . ...|..||| . || |||.||
lekkleeg.kvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptk.enstgyinassikvsvggkersyivaqgPleltvqdfWqmv

WEYRSEVVVMMTGIREGGRIKCHRYWPEH--TEAPLDTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVID---LVK
||   ...||.| ..|.|. |...|.|..   .  .. ..|...   .|. . .| |.|.|.|  |.  | | |. .|.|||||||..  . ..    |.
WeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevq

AVRRARTDRA------LPAVVHCSAGIGRTGTFLAVDMGIRSLNNPhRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
.|||. ..         | .||||||.||||  . .|. | .|..  ...|.   . .||.||   .||. || ||....  |.
svrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehn.eeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl

subfamily_PTPRN_pd Subfamily PTPRN 81-350 5.3e-47 155.0 In-house 21-292 (297) alignment
Range on Protein: 81-350
Range on HMM: 21-292/297.0
LHEALRDREMLEEEFERAPHMLVGPDTL--PNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDG-YNQPKEFIATQGPKPETVDDFWRMV
|.. |.... ||.|.|   .    | |    ...... |||....||   .|| |..   .  | |.|| ..     .   .|||||| ..|| |||.||
ledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmv

WEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLdtQNFQISIASTE-NMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRR
||  . |.|..| ..| |  .|.||||.. ..    . ... . |     . |..  . |    .  ||.|. | |  ||..||| ..  .... . | .
weqGvvvivnltrleeegvkqckrywpdeGsevy..hiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnk

ARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
.   |. | |||||.| ||||.....|. .  |..  . .|.   . .|| || | ..|  |. |. .|. . |
syrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev

0047943 (Phosphotyrosine protein) phosphatases II 82-350 1.5e-83 275.7 In-house 5-272 (273) alignment
Range on Protein: 82-350
Range on HMM: 5-272/273.0
HEALRDREMLEEEFERAPHMLVGPD-TLPNDPRVAMKNRYTNILPTPATRVPLsqigPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEY
 | | .. .|.||||. . . .  . .  . |.   ||||..|||   .|| |    .|  | | ||..|||||....|||||||.|.||.||||||||.
lekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

RSEVVVMMTGIREGGRIKCHRYWPEHTEA-PLDTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRART
...|.||.| . | ||.||..|||.  .  .|   .|.. . |.|. ..|....|.|..  .| .| | ||..|.|||||||. . ........||.|. 
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale

D--RALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPhRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
   .  | |||||||.||||||.|.|. .. |.   . |||.  . .||.|| |..||. ||.|...|. .|.
alpsngpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 82-351 6.4e-46 151.4 In-house 8-294 (301) alignment
Range on Protein: 82-351
Range on HMM: 8-294/301.0
HEALRDREMLEEEFERAPHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGP--DALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWE
|.|    . .||....  ..   . |.  . . .. ||. || . .  |. |..      .  .|.||...|||.. |.|||.|||  .|. ||||..|.
hvaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwq

YRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQNFQISIASTENMKHYILTKLTLE---------------HRASGATRAVSHFWFTNWPDHGV---P
..   .||.|. .|| . ||..|||. ..   .  .|.. . .. ..  ... .|..                 ... ... |  .  |.||..||   |
ekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrep

HETWEVIDlvKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
.   .|||  . . | .     | |||||....|.|.. .|..|.        |||||.    .| .. | ..|  || ....... |..
rtvLqvid..dvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQcka.egVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 82-348 1.2e-45 150.6 In-house 13-234 (392) alignment
Range on Protein: 82-348
Range on HMM: 13-234/392.0
HEALRDREMLEEEFERAPHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYR
 |  |   .. |||   |   . |.|  . .    |||| ||||  ..|| |  |   . | |.|| ....... | .||.|||.. ..|||||||.. .
veknrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqen

SEVVVMMTGIREGGrikchrywpehteapldtqnfqisiastenmkhyiltkltlehrASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDR
   ..|.| ..||                                                 .|.|. | ||.|||..||. |  .. ..| |.    . 
vttiamvtklkegd............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqy

ALPAVVHCSAGIGRTGTFLAVDMGIRSlNNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKD
. | ..|||||.||||  ...|  .    .  |.||||  . ..| .|   .||  || |.. |. .
thpliihcsagvgrtgvvisidsvvah.akktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle

0051299 (Phosphotyrosine protein) phosphatases II 85-350 4.9e-90 297.1 In-house 19-286 (288) alignment
Range on Protein: 85-350
Range on HMM: 19-286/288.0
LRDREMLEEEFERAPHMLVGPD-TLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSE
...  .|.||||. ...|. .. .  . |    ||||..|||   .|| || ....  |.| ||...||||....|||||||.|.||.||||||||....
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvr

VVVMMTGIREGGRIKCHRYWPEhtEAPLDTQNFQISIASTENMKHYILTKLTLEHR----ASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRART
|.||.|.. | ||.||..|||.  . .|   .... . |.| ...|....|....      .| .| | ||..|||||||||. . ...|....||.|. 
vIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala

DRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPhRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
..  | |||||||.||||||.|.|. .. |..  ..|||.. . .||.|| |..||. ||.||..|. .|.
sgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0040438 (Phosphotyrosine protein) phosphatases II 85-351 1.4e-85 282.6 In-house 14-277 (317) alignment
Range on Protein: 85-351
Range on HMM: 14-277/317.0
LRDREMLEEEFERAPHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEV
..|  .|.||||. ... . . .  . |    ||||..||| ...|| || .|.|  |.| ||..|||.|....|||||||.|.||.||||||||....|
ksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

VVMMTGIREGGRIKCHRYWPEhtEAPLDTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALP
.||.|   | ||.||..|||.  . .|   .|.. . |.| .....|..|..|.  .. .| | ||..|.|||||||  . ...|...|||.|. |.  |
ivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggp

AVVHCSAGIGRTGTFLAVDMGIRSLNNPHrVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
 .||||||.||||||.|... .. |.  .  |||.  . .|| ||.|..||. || |...|. .|..
vlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylk

0043336 (Phosphotyrosine protein) phosphatases II 85-350 4.5e-83 274.2 In-house 16-277 (278) alignment
Range on Protein: 85-350
Range on HMM: 16-277/278.0
LRDREMLEEEFERAPHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEV
| .. .|..|||. ... ... .  . |    ||||..||| . .|| || .| |  |.| ||..|||||.|..||||||| ||||.||||||||.....
lnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

VVMMTGIREGGRIKCHRYWPehtEAPLDTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALP
.||.|.  | ||.||..|||   . .|   .|..   ..| ...|....|..... .| .| | |.....|||||||. .  ..|..||||.|. |.  |
ivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngp

AVVHCSAGIGRTGTFLAVDMGIRSLNNPHrVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
 .||||||.||||||.|... .. |.. .  ||..  . .||.||.|..||. || |...|...|.
vlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealleyl

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 85-347 1.6e-73 242.3 In-house 17-276 (288) alignment
Range on Protein: 85-347
Range on HMM: 17-276/288.0
LRDREMLEEEFERAPHML-VGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSE
 |.|. ..||..  . .     .|  . .. | |||| ||||   .|| | .    | . |.||...||... |..|||||| ..||.|||..|.|....
arnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

VVVMMTGIREGGRIKCHRYWPEHtEAPLDTQNFQISIASTENMKHYILTKLTLEhrASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRAL
 .||.|.. |||. ||..|||.  . |    .... . .........| || ||   ..  . . .. .. |||||||. . ....|.. |  | .. . 
tivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtg

PAVVHCSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMK
| .||||||.||||||.|.|. |  ... . ..||.| . ||| ||   .||  || |..... 
piivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevll

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 85-348 3.6e-64 212.1 In-house 30-289 (319) alignment
Range on Protein: 85-348
Range on HMM: 30-289/319.0
LRDREMLEEEFERAPHMLVG--PDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRS
  |.  || || ||... |     |  | ..   |||..|||.   ..| | ..     | |.|| ||.|| ... .||.|||...|..|||||.|||..
dddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweync

EVVVMMTgireggRIKCHRYWPEHTEapLDTQNFQISIASTENMKHYILTKLTLEHRA-SGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRA--RT
  .|..|      . || .||| ...     ..|.... | |. . |.. .. | . .     | .  | |  |||.|||. . ... ||| ||    . 
stivllt......kdkcsqywplkiv..ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltske

DRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKD
.   . |||||||.||||.....|. .  ...  . |||.  .  || ||   .| .||| |.. |. .
nhranivvhcsaGvGrtGvyivldvlldrmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_PTPRA_pd Subfamily PTPRA 86-353 1.9e-72 238.9 In-house 29-298 (330) alignment
Range on Protein: 86-353
Range on HMM: 29-298/330.0
RDREMLEEEFERAPH-MLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEV
 | ... |||.  |   . .   | .      |||. ||||   .|| ||..     | |.|| |.|||.. ..|||.|||| |||.|||||.||..|  
ddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksat

VVMMTGIREGGRIKCHRYWPEhtEAPLDTQNFQISIASTENMKHYILTKLTLEHR----ASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTD
.||.| ..|  . ||..|||.  |  .   | ....  .. ...| . |. ...        ..| |. | || ||| ||| |.  ...|.|.|.. .  
ivmltelkerkeekcaqywPd..eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqq

RALPAVVHCSAGIGRTGTFLAVDMGIRSLNnPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVTPG
 | | |||||||.||||||...|  .  ..   |.||||. . .||.||   .||  || |.......|   |
sagpivvhcsaGvGrtGtfivldavlervk.aerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylyg

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 86-351 1.2e-62 206.6 In-house 15-277 (515) alignment
Range on Protein: 86-351
Range on HMM: 15-277/515.0
RDREMLEEEFERAPHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVV
|   .. |||   |   . |.|. ..     |||| ||||   .|| |  |  .  | |.|| .. ...  | .||.|||.. .||||||.|....   .
rhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvtti

VMMTGIREGGRIKCHRYWPEHTEAPLDTQNFQISIASTENMKHYILTKLTLEHRASgaTRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPA
.|.|  .|| .||| .|||..    .   ...... |.|     |  |||. .     .|.|  | ||.|||.|||..|  .. |.|.|.  .   . | 
amvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpl

VVHCSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
..|||||.|||| ....|  .   ..  |.||||  . ..| .|   .||  || |...|..... 
iihcsaGvGrtGvvisidsvvahakt.trmvdvfnfvtnirqkrpylvqtqeqyafiygavledll

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 86-351 1.6e-61 202.9 In-house 16-278 (315) alignment
Range on Protein: 86-351
Range on HMM: 16-278/315.0
RDREMLEEEFERAPHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVV
|   .. |||   |   . . .   ..    |||| ||||   .|| |  |  .  | |.|| .. .... | .||.|||.. .||||||||....   .
rhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvtti

VMMTGIREGGRIKCHRYWPEHTEAPLDTQNFQISIASTENMKHYILTKLtlEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPA
||.|  .|| .||| .|||..     .  ...... |.|     .  ||    | | ..| |. | ||.|||.||...|  .. |.|.|.  .  .  . 
vmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsl

VVHCSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
.||||||.|||| ....|  .  ...  |.||||  . .||..|   .||  .| |...|..... 
lvhcsaGvGrtGvvisidevvaqikr.trsvdvfnfvknlrakrpylvqteeeyafiydavledll

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 87-355 8.4e-56 184.4 In-house 21-293 (325) alignment
Range on Protein: 87-355
Range on HMM: 21-293/325.0
DREMLEEEFERAPHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVvV
|.. .  ||.  |       .    |    |||. |...   .|| |   . |. | |.||...  . . . |.|.| |...|..|.||.| ..|. | |
dqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsv.v

MMTGIREGGRIKCHRYWPEHTEAPLDTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEV---IDLVKAVR---RARTD
... . ..|  .|  |||..         ..... . |..  |.  .| .     | ||.|  | .  |.| ||..    .   ..|||||    .| | 
vvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantk

RALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHRvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVTPGNS
 . | .||||||.||||.|...   .  . .  | ||.|| . ||| .|   ..|  || ....|. ...  ||.
astpilvhcsaGvGrtGvfislysalakvieesr.vdifgfvkklrkdrpsmvetvdqyiliyealveaymsgnt

subfamily_CG42327_pd Subfamily CG42327 87-277 1.4e-37 124.1 In-house 3-193 (319) alignment
Range on Protein: 87-277
Range on HMM: 3-193/319.0
DREMLEEEFERAPHMLVGPDTLPndPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQ-PKEFIATQGPKPETVDDFWRMVWEYRSEVV
 || . |||.  | ..   | .|  .    |.|. |..| | ||| | .|| |  . |..|..| ||.. |  .||.| .  ..  ||||.||| .| |.
rredvaeefrdlPqliaradevP..vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvi

VMMTGIREGGRIKCHRYWPEHTEAPLDT--QNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFtNWPDHGVPHETWEVIDLVKAVRRA
| .| . | |  .| .|.| .   .      ......   |  ..|... | | .     .| ..|.|. .|.. .|| |   .| ..  || .
vqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 87-164 6.7e-09 29.8 In-house 22-95 (95) alignment
Range on Protein: 87-164
Range on HMM: 22-95/95.0
DREmLEEEFERAPHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQigpDALSTYMNANFVDGYNQPKEFIATQG
|.| ...||   .     | |         |||. ||.|  |||| |.       | |.|| ||||| . . .||.||
dqe.fdnefksismtsgapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 88-355 1.2e-72 239.7 In-house 21-288 (305) alignment
Range on Protein: 88-355
Range on HMM: 21-288/305.0
REMLEEEFERAPHMlVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVM
 . ||....  ..    .  . ..   . |||...| . .  |. |..   .  | |.||..||||.. |..|..||| ..||.||||...|.. ...||
dkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivm

MTGIREGGRIKCHRYWPEHTEAPLDTQNFQISIASTENMKHYILTKLTLEH-RASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRART-DRALPA
.|...|||. ||..|||| .  . . ..|.. . |..... ||  ||..   . .  .|.|... .|.|||||||...  ...|.| |....  |.  | 
ltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpl

VVHCSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVTPGNS
.||||||.||||.|.|||. .  |..   |||||. . .||..| . .||  || |.|.|.....| |. 
lVhCsagvgRtGvfiavdialerlkk.EevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdt

subfamily_PTPN6_pd Subfamily PTPN6 89-351 1.8e-67 222.5 In-house 26-298 (306) alignment
Range on Protein: 89-351
Range on HMM: 26-298/306.0
EMLEEEFERAP---HMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSqiGPDA-LSTYMNANFVDG--YNQPKEFIATQGPKPETVDDFWRMVWEYRS
. .|||||.     .. .   .  . |. . |||| ||||   ||| |.   |.   |.|.|||....   .. |..|||||  ..|| |||||||.  |
agfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqens

EVVVMMTGIREGGRIKCHRYWPEHTEAPLdTQNFQISIASTENMKHYILTKLTLEH-RASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDR
.|.||.|   | |. || ||||...| .  . . ...  | .....||| .|.... . .. .| | .. |..|||||||...  |.|... |.| . . 
rvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeel

A----LPAVVHCSAGIGRTGTFLAVDMGIRSLNNP--HRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
.     | ||||||||||||||. .|. .. ...   .  .|.   . ..|.|| | .||  || ||..|.| |. 
eeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie

subfamily_Ptp69D_pd Subfamily Ptp69D 89-354 2.3e-64 212.4 In-house 22-290 (307) alignment
Range on Protein: 89-354
Range on HMM: 22-290/307.0
EMLEEEFERAPHMLVGPDTL-PNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVM
. |..|.|. ..  .  .|   .    |.|||| .| .   ||| |..|  .. |.|.||.|. ||.. |.||| |.|  .|..|||||..|  ....||
fglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivm

MTGIREGGRIKCHRYWPEHTEAPLDtqNFQISIASTENMKHYILTKLTLEHRA-----SGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRA
.. . |  | ||..|||. .|   .  .  . ..|.|....||  .| . .         ..| |  . .|.|.|  ||. .  ...|.. ||       
lsnlteknrkkcakYWpiedevqyg..dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnr

LPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHRvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVTPGN
 | ||||||| ||.|.|.|.|. .  |.. .. ||.|  . .|| ||   .| . || |...|. || . |.
sPivvhCsaGvgrsgifvaldsllqqlkaedk.vdifetvkdLrsqRnllvqsleqYvflyralldyssygd

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 89-353 3.6e-48 159.1 In-house 20-282 (439) alignment
Range on Protein: 89-353
Range on HMM: 20-282/439.0
EMLEEEFERAPHmlVGPD-----TLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSE
|...|.||      . ||     .|  .     |||| .. .   ||| | .|     | |.|||...|| ..| .||||||| ||.|||||.|.| .. 
eifkeifekins..tspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktv

VVVMMTGIREGGRikchrYWPEHTEAPLdtQNFQISIASTENMKHYILTKLT--LEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDR
 .||.| . |  .     |||  .|.     .  . .    .. .|..  .    |.  .   |.| .| .. |||. || ..  |.|...|.  |  ..
tivmltnlvesyk.....ywpsdaevcy..gdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandke

-ALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHRvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVTPG
   | |||||||.||||| .|.|. .  |.   . ||. | .  || ||   .|...||.|...|. . .  |
eygpvvvhcsagvGrtGtiialdialeqlklenk.vdikgivkvlrkqrkqmvqalcqyvfiynavledivyG

subfamily_PTPRD_pd Subfamily PTPRD 90-354 3.1e-96 318.2 In-house 24-285 (564) alignment
Range on Protein: 90-354
Range on HMM: 24-285/564.0
MLEEEFERAPHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMT
 .|||...  .    . .  | |   .|||| ||..  ..|| ||..  |  | |.||.|.|||...|..||||||..||..||||||||..|...||.|
kfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmlt

GIREGGRIKCHRYWPEHtEaPLDTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHC
 ..| |. |||.||||. . .   ....... ..|....|......|..  |  .| | .| ||.|||||||... ...||.. ||..... | | ||||
kleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhC

SAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVTPGN
|||.||||||...|. .. ...  ..||... ...||.||   .||  || |.|.|. .... ||
SaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgn

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 90-354 2.6e-79 261.6 In-house 24-287 (319) alignment
Range on Protein: 90-354
Range on HMM: 24-287/319.0
MLEEEFERAPHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMT
.||.||.   .      .  . ..   ||||.|||.   ||| ||..     |.|.||.|.|||.. ..|||||.|. .|..||||||||..| .|||.|
llekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmlt

GIREGGRIKCHRYWPEHTeaPLDTQNFQISIASTENMKHYILTKLTLEHRASGA-TRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTD-RALPAVV
.. | ...|...||||..  . .  .. . . . |....||  ||.|....|   || |.|| .|.||||.||...  ..||.| .|..|    . | ||
klveklkvklkkywpeen..feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivv

HCSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVTPGN
|||||.||||||...|. .  ...   |.|||  . .|||||   .|.  || |...|. ..|. |.
hCsaGvGRtGtfivldamlervke.egvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 90-350 4.9e-78 257.0 In-house 6-268 (274) alignment
Range on Protein: 90-350
Range on HMM: 6-268/274.0
MLEEEFERAPHMLvgPDTLPNDPRVAMKNRYTNILPTPATRVPL-SQIGPDALSTYMNANFVDGYN-QPKEFIATQGPKPETVDDFWRMVWEYRSEVVVM
 ||.||   |     .   .. .. . ||||..||| . .|| | |. . | .|.|.|||.. ||. . | ..||||| |.||.|||||... ...|.||
dlekeflelPlnf..dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivm

MTGIREGGRIKCHRYWPEHTEAPLDT--QNFQISIASTENMKHYILTKLTLEHRASgaTRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALP-
.| ..|  . ||..|.|..... ..   ....| . .. . ..| ..||.|..  .  .| | |.|.|.|||| .|... ...|||. |...|.... . 
ltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenakl

--AVVHCSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
  .|||||||||||| |.|.....| |.. . ||||.. . .|| .||| .||  || ..|.|.  |.
apvvvhCsaGiGrtGcfiaisiavrqlre.eivvdvlkivcnlrldrGGmvqtseqyelihralclyl

0046845 (Phosphotyrosine protein) phosphatases II 91-351 9.5e-88 289.5 In-house 2-275 (284) alignment
Range on Protein: 91-351
Range on HMM: 2-275/284.0
LEEEFERAPHMLVG---PDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPD-ALSTYMNANFVDGY-----NQPKEFIATQGPKPETVDDFWRMVWEYR
||||||. ... |    . .  . |    ||||..|||   .|| |. ...|   |.| ||..||||     ...|.|||||||.|.||.||||||||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SEVVVMMTGIREGGRIKCHRYWPEHtEAPLDTQNFQISIASTENMKHYILTKLTLEHRA-SGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRART-
..|.||.|.. | ||.||..|||.  . .|   .|.. . |.|....|....|.|..   .| .| | ||..|.|||||||...  .......||.... 
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-DRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHR--VVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
 ..  | |||||||.||||||.|.|. .. |.. ..  .|||.. . .||.|| |..||. ||.||..|. .|. 
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 91-354 1.9e-82 271.8 In-house 22-284 (318) alignment
Range on Protein: 91-354
Range on HMM: 22-284/318.0
LEEEFERA-PHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMT
|.||.||  ..      .  ..|  ..||||.|||.   ||| |...  .  | |.|||..|||.. |..||.|.| |||..||||||||  | |.||.|
lseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmlt

GIREGGRIKCHRYWPEHTeaPLDTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRAR-TDRALPAVVH
 ..| |..|.|||||..   .   .. .. . .. ....|.| ....... . ..| |  . .|.|||.|||... ...|||. |..|  .  | | |||
qeeergkakvhryWPskg..srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvh

CSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVTPGN
||||.||||.|.|||. .. ...   .||||. . .||.||   .||  || |.......... |.
CsaGvGrtGvfiavdillerika.ealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd

subfamily_PTPN13_pd Subfamily PTPN13 92-346 2.4e-72 238.5 In-house 14-265 (273) alignment
Range on Protein: 92-346
Range on HMM: 14-265/273.0
EEEFERAPHMLVGPDTLPNDP-RVAMKNRYTNILPTPATRVPLSQIGPdalstYMNANFVDGY--NQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMM
.|||.   ..    ..      .   |||| |.||  .|||.|.. |.     |.||...     ..  |.||.||| ||||.|||.|||| ..||..|.
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TGIREGGRIKCHRYWPEHTEAPLDTQN-FQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDrALPAVV
|  .|.|..||||||||... .|  .| ....   ..... . . .|.... .||..| |.|. |..||||||| .. |.. .|. ||| .|| |.| ||
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtd.agPivv

HCSAGIGRTGTFLAVDMGIRSLNNPHrVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAM
||||||||.||....|. .  ... .  .||   . ||| || | .||  ||.||..|.
hcsaGiGrsGtlitidvvlglierdk.efdvkeivrklreqrqgvvqtkdqyifvykai

subfamily_PTPRB_pd Subfamily PTPRB 93-351 2e-85 281.4 In-house 29-286 (293) alignment
Range on Protein: 93-351
Range on HMM: 29-286/293.0
EEFERAPHMLVG-PDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGI
||.|.  ..      .  . .. . |||||||||  ..|| |...  .. | |.|||...|||.|.|||||||| ||||||||||||| .|...||.| .
eeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltql

REGGRIKCHRYWPEHTEaPLDTQNFQISIASTENMKHYILTKLTLEHraSGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRAR--TDRALPAVVHC
 |.|..||..|||...| |    . .... ..|....... .|..|.  . ..| | .. || |||||||..|. ..|.|..||.|   | .. | ||||
vekgkvkCeeYWPadee.pvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhC

SAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
|||.||||||.|.|. ...... . .||.|| ...||..|   .||  ||.|.||.. |...
saGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvldllr

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 101-350 5.4e-79 260.0 In-house 7-264 (270) alignment
Range on Protein: 101-350
Range on HMM: 7-264/270.0
MLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYN-QPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKC
  . ...||.  | .  |||..|||.||||| |...  |  ..|.|||.| |.. ..|..||..||.| |. .||||.|| ... .||.||. | || ||
eetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkC

HRYWPEHTEAPLDTQNFQISIASTE--NMKHYILTKLTLEhrASGATRAVSHFWFTNWPDHGVPHETW------EVIDLVKAVRRART--DRALPAVVHC
 ||||....  ..... .|......  ... ||||.|.||   .| .| . |||...|||||||.|.       ... ...|||| ..  |.| | .|||
erYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHc

SAGIGRTGTFLAVDMGIRSLNNPHRvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
|||.|||||..|.|...| |.. .. |||   . .|| .|   .|. .|| |...|.  |.
saGvgRtGtlialDiavrlLeetkk.vdvlaiieelRkdRmalvqhpeqyeflykavveya

subfamily_PTPRK_pd Subfamily PTPRK 104-348 3.8e-68 224.6 In-house 34-275 (314) alignment
Range on Protein: 104-348
Range on HMM: 34-275/314.0
GPDTLPNDPRvAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYW
| |.  .| .  .|||...||.   .|| | .|  |. | |.||...|.|..|..||.||||..||| ||||.|.....  .||.| . | ||.|| .||
gwdaakkden.reknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyW

PEHTEApldTQNFQISIASTENMKHYILTKLTLEH--RASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLA
||.||     ..... . .||  . ..   ...|.  |.  ..| | .| |..||||.||..   ...||. |   . ..| . ||||||| ||||||.|
Pedtev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfia

VDMGIRsLNNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKD
.|. .  . . ..|||||  . .||...   ..|  || |..... .
idivld.mieregvvdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 105-350 2.3e-59 195.9 In-house 40-280 (315) alignment
Range on Protein: 105-350
Range on HMM: 40-280/315.0
PDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWP
|    ..     |||| ||...  .|| |  .  |  | |.||||.||||... .||.|||....|.||||.|.|.    .||.|.. || . |. .|||
pldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp

EHteaPLDTQNFQISIASTENMKHYILTklTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDM
..    .   .. ..  | |  ..|     ||        | |  . .| ||| |||. |  ...|.. |.. .|. . . |||||||.||||||...| 
dk...kviyGkitvtrkseevnteytvr..tlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitlda

GIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKD-YV
 .  ..   ...||.  . ..| .| . .|.  || |...|. . .|
vldqaea.enaidvynfitgvrqnrikmvqvaeqyqfiydalletfv

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 107-348 2.8e-62 205.8 In-house 18-253 (284) alignment
Range on Protein: 107-348
Range on HMM: 18-253/284.0
TLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTgireggRIKCHRYWPEH
|  | ..   |||...||.   ..| | ..     | |.|| |. || ... .||||||...|..|||||.|||..  .|..|      . || .||| .
tfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplk

TEapLDTQNFQISIASTENMKHYILTKLTLEHRA-SGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRA--RTDRALPAVVHCSAGIGRTGTFLAVD
..     ..|.... | |. . |.. .. | . .     | .  | |  |||.|||. . ... ||| ||    . .   . |||||||.||||.....|
iv..ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld

MGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKD
. .  ...  . |||.  . .|| ||   .| .||| |.. |. .
vlldrmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_PTPRG_pd Subfamily PTPRG 108-354 1.2e-71 236.6 In-house 41-291 (563) alignment
Range on Protein: 108-354
Range on HMM: 41-291/563.0
LPNDPRVAMKNRYTNILPTPATRVPLSQIGP-DALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEh
  ..|    ||||.||..   .|| ||..   .    |.|||..|||.. |.||||||| ..|.||||||.|| .....||.| . | || ||..|||. 
hsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.

tEAPLDTQNFQISIASTENMKHYILTKLTLEHRA---S---GATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFL
 . ... ...|. . ..| .  |   .|.....           . | .. .|.|||||||. .  |.  ||   .|. . | | |||||||.|||||..
.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyi

AVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVTPGN
..|  .. ... . .|.||| . ..|.||   .||  ||.|.|.|. . .. ..
vldtllkqiqq.enavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 108-349 1.1e-43 144.0 In-house 31-268 (281) alignment
Range on Protein: 108-349
Range on HMM: 31-268/281.0
LPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALST-YMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEH
  |.|    ||||.||     .|| |    |.  || |. ||..      . .| ||||| ||  |||||.|.  .  .||.  . |  | ||  |.|  
vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn

TEAPLDTQNFQISIASTENMKHYILTKLTLEHraSGATRAVSHFWFTNWPDHGVPHETwEVidLVKAVRRARTdRALPAVVHCSAGIGRTGTFLAVDMGI
. . |. ... .|   .   |  . |.| | .   | || ..|. . .|||  ||. . ||  ..| .|. |. |. | |.|||||.||.||..||.. .
ahcclqfdklsvsyedstvnkslvttrlnlsy..egetrlithwlwkewpdwqvpess.ev..mlkilrkira.rstppvihcsagvgrsgtlmaveial

RSLNNPHRVVDVFGDMIKLR-TQRGGSIQTFVQYLFVHQAMKDY
.|. .   . |.   . .|| | |  |.||. ||... . . |.
qsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

subfamily_PTPN3_pd Subfamily PTPN3 110-346 2.2e-63 208.8 In-house 37-271 (280) alignment
Range on Protein: 110-346
Range on HMM: 37-271/280.0
NDPRVAMKNRYTNILPTPATRVPLSQigpdALSTYMNANFVD----GYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPE
. |. . |||| .|||  |||| |..    . . |.|||.|.    . .. . .|||||| ..|. |||.|||| .|...||.| . | ||.|||.||||
rkpenlsknryrdilpydatrvklke....setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe

HTEApLDTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMG
...  |.  .|.. . .... | |.| .|.|.....   | . .. ...|||||||... .....|. ||..|. .  | |||||||||||| ...... 
tede.leygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilleta

IRsLNNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAM
.  | . .. | .   . ..| ||.  .||  || || .|.
la.lieaaepvypldivrtmrdqramlvqtasqykfvCeai

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 110-350 2.1e-53 176.0 In-house 38-277 (287) alignment
Range on Protein: 110-350
Range on HMM: 38-277/287.0
NdprvAMKNRYTNILPTPATRVPLSQIgPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHtEA
.    . ||||...||   ||| ||.  ..  | |.|||.| .|.. ..|||.||| . || ||||.|.| || .|..||   | .| ||..||||. | 
a....vkknryadvlPiddtrvllsae.gelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.ev

PLDTQNFQISIASTENMK-HYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAV----RRAR-TDRALPAVVHCSAGIGRTGTFLAVD
|.    . . . . .... .|    | | .  .  .| |  . . .|||....  .  .| .|  |      || .. . | |||...||||.|..||. 
PmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatl

MGIRSLNNPHRvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
. .. |..  | |||   .|.|| .| . .|. ||. .. .|.  | 
vlvsrledlGr.vdvaavvirlreyraalvqavvqlrllyealvtyy

subfamily_PTPN12_pd Subfamily PTPN12 111-351 1.8e-74 245.2 In-house 37-278 (290) alignment
Range on Protein: 111-351
Range on HMM: 37-278/290.0
DPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAP
 ..   |||| .|||   .|| ||.|  .  | |.||||. | ....|.||.||| |.|.||||||.||.. |.|||.  . | |..||.|||||..| .
keenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeee

LDTQNFQISIASTENMK-HYILTKLTLEHRasGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSL
| ...|...  . ....  ...  |..|..  ...| |  | .|.|||||||. . ....|...||. ... . | |||||||.||||| .|.|.  . |
lefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrell

NNPHR--VVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
.. .    .|||  ...||.||   .||  || .|..|. ..|.
kaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

0049772 (Phosphotyrosine protein) phosphatases II 111-352 4.2e-43 143.6 In-house 43-282 (314) alignment
Range on Protein: 111-352
Range on HMM: 43-282/314.0
DPRVAMKNRYTNILPTPaTRVPLSQIGPDAlSTYMNANFVDGYnqpKEFIATQGPKPETVDDF----------WRMV--WEYRSEVVVM-----------
....  ||||..||| . .|| |.  . .  | | ||..|||.   . |||||||...||.||          ||||  ..... ..||           
lflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------MTGIREGGRIKCHRYWPEHTeapldtqnfqisiastenmkhyiltklTLEHRASGATRAVSHFWFTNWPDHGVPhETWEVIDLVKAVRRA
           ... ..| . . ......                            .  . ..  .|.. ... ...||...|  .  . ........|
rLdaAlgKtpllildgngneptaadlellk...........................eelydpelferlgikylripvpDgsap.lledfdeflefieea

rtDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNnphrvVDVFGDMIKLRTQRG-----GSIQTFVQYLFVHQAMKDYVTP
  |.  | .|||.||.||||||..... .. |.     |..   .  .| .|      |.|... ||.|...|...|.  
..dkggpvlvHCkaGkgRtgtfvvaaylmkllg.....vsleealedvrlkRpinpnpgfieqleqyefilealleylkf

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 111-260 6.1e-17 56.0 In-house 93-235 (244) alignment
Range on Protein: 111-260
Range on HMM: 93-235/244.0
DPRVAMKNRYTNILPTPATRVPLSQIgpDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGgrikcHRYWPEHTeaP
.|  . |||    ||    |||||.       ||.|| ||    .  |.| || |  .|  |||.|. |   .|.|..  . |        |||.    |
npnnswknregaglpfdfnrvplskg..smgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdse..p

LDTQ--NFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGV
|.    .  ....  ...|    ..| .|     . .|.. |  .|||  | 
lewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgt

DSPc_SM00195 112-350 5.3e-80 263.9 In-house 24-262 (263) alignment
Range on Protein: 112-350
Range on HMM: 24-262/263.0
PRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPL
..   ||||.||||   ||| |...  .  |.| |||...|.|..|..||||||.|.||.|||||||| .....||.|   | |..||.|||||  . . 
kknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggke

DTQNFQISIASTENMK-HYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLN
. ..... . ..|..| ..||..|.|.. .   || | .....||||||||..| .|..|..||.  .     | |||||||.||||||...|. ...|.
tfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskle

NPHRvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
. .. ||.|  . .||.|| |..||. ||||...|. .|.
eekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 112-350 5.3e-80 263.9 In-house 24-262 (263) alignment
Range on Protein: 112-350
Range on HMM: 24-262/263.0
PRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPL
..   ||||.||||   ||| |...  .  |.| |||...|.|..|..||||||.|.||.|||||||| .....||.|   | |..||.|||||  . . 
kknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggke

DTQNFQISIASTENMK-HYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLN
. ..... . ..|..| ..||..|.|.. .   || | .....||||||||..| .|..|..||.  .     | |||||||.||||||...|. ...|.
tfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskle

NPHRvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
. .. ||.|  . .||.|| |..||. ||||...|. .|.
eekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_PTPN9_pd Subfamily PTPN9 112-350 9e-74 243.2 In-house 40-290 (297) alignment
Range on Protein: 112-350
Range on HMM: 40-290/297.0
PRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPL
.    |||||..|    ||| |...  |  | |.||||||||.|.| ||||||| ..||.|||||||| .  |.||.| . | ||.|| .|||...|.  
ranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessa

DTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTD-------------RALPAVVHCSAGIGRTGT
.  ....|  ..|....|  ..|....   . .| |.|| |. |||.|||... ...|....||....              .  | |||||||||||||
efgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGt

FLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
| ..|. .  |..   .|||.  . .|||||  ||||  || | ..|. .| 
fitldiclsrlee.vgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 112-351 1.3e-65 216.1 In-house 7-243 (250) alignment
Range on Protein: 112-351
Range on HMM: 7-243/250.0
PRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIkCHRYWP-EHTEap
|.   ||||..|..   .|| | .   |  | |.|| |..||.. | ||||||| ..|. ||||||.|. |...||.| ..| ..  .|.||| |..|  
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae..

lDTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTD-RALPAVVHCSAGIGRTGTFLAVDMGIRSL
    . ..|. |.|..  |. .|| | ..     | | .. |..||| |||...  |..|.| |.. .    . | .|.||||.||.|.|.|.|  .  |
.kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerl

NNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
..  .|||||  ...||..| .....  || ||..... ...
kk.ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald

subfamily_PTPN1_pd Subfamily PTPN1 112-346 1.1e-55 183.4 In-house 30-267 (290) alignment
Range on Protein: 112-346
Range on HMM: 30-267/290.0
PRVAMKNRYTNILPTPATRVPLSQIGPdalsTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTE---
|.   .||| .. |   .|. | .        |.||..|.  .  ...| |||| |.||| ||.|||| .|  |||.  . | ..|||..|||.. |   
penrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeeke

APLDTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRAR--TDRALPAVVHCSAGIGRTGTFLAVDMGI
  |.  .... . |.|. ..|.. .| || . .  || ..|| .| ||| |||.     ....  ||..   ..   |||.||||||||.|||  ||  .
llledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtcl

RSLNNPHR--VVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAM
  ... .    ||.   ...|| .| | |||  |  | ..|.
vliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 113-350 5.9e-77 253.5 In-house 40-276 (281) alignment
Range on Protein: 113-350
Range on HMM: 40-276/281.0
RVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTeAPLD
   .||||.||    |||| ...   .  . |.|||||.||...||.|||||| |.....||.||||.. ...||.|   |.|..|||||||... . | 
envlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddn.selk

TQNFQISIASTENMKHYILTKLTLeHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRA-LPAVVHCSAGIGRTGTFLAVDMGIRSLNN
  .....  ..|. ..||  |..| .| || || |... .|.|||||||..| |...  |.|..... .   | |.|||||.|||||..|.|  ......
ygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkavea

PHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
 .. .||   . .|| .|   .|| ||| ||..|..|..
eleeldvkavvaelrkernlmvqtvvqyefvykavldal

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 113-354 1.1e-72 239.8 In-house 55-294 (298) alignment
Range on Protein: 113-354
Range on HMM: 55-294/298.0
RVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLD
.   ||||..|..   .|| |...  |  |.|.|| |...|.. . |||||.| .||| ||||||.|. ....||.| ..| ...|.|.|||.. ..  .
enkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketyg

tqNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRA-LPAVVHCSAGIGRTGTFLAVDMGIRSLNN
  ....|. |.|..  .| .||..... .  .| | .. ||.|||.|||...  |.||.. ||. ...    | .|.||||.||.||| |.|  .  ...
..eitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkk

pHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVTPGN
  .|||||  .. ||..| |..||  || |...|. .... .|
.eqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn

subfamily_ptpA1_pd Subfamily ptpA1 113-310 5.8e-44 145.5 In-house 46-257 (418) alignment
Range on Protein: 113-310
Range on HMM: 46-257/418.0
RVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGyNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPL-
. . |||||||||   ||| | .|     | |.|||..||   ||.||.|||| |.|. |||||||| |  ..||..   |  |||| |||||.      
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf

---DTQNFQI---SIASTENMK---HYILTKlTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRA------RTDRALPAVVHCSAGIGRT
      |  .   |.   | ..   . |.|.  .     | || .... .  |||| .|  |  . .|....          .|| .| .||||||.|||
siygngnevfgtysvelveviqdpereiitr.nirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrt

GTFLAVDMGIRSLN
||| .  . .. |.
gtfctavimmkkld

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 114-350 1.1e-31 104.9 In-house 33-259 (267) alignment
Range on Protein: 114-350
Range on HMM: 33-259/267.0
VAMKNRYTNILPTPATRVPLSQIGPDalstYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGgRIkcHRYWPEHTEAPLDT
.. .||. . ||   |||.|..   .    |.|| .|.||.. . ||.||.|   |. ||. .. ...  |.|..| . ..  |  ...|| .       
nqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd.ni..rlfwPPkmgqakky

QNFQISIASTENMKHYILTKLTLEHRASGAtRAVSHFWFTNWPDHGVPHETWEVIDLVKAvRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNpH
|.. .  .  .. . | .  | |. .   | . |. ... .|      .   . .  . | .    .   | ||.||.|.||.|||| .|  .. . .  
qdltvehslekeendyqiitlelkfknesa.hnvtlyyykkwnintnnkpylkplfgila.knqlengnrPlvvacsdGvGrsGtflvidsqlerakt.e

RVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
 |.|.|  . |.| || | ..|  .|...|. . .| 
gvsdifdflrkirsqriglvdtkeryiyihellaeya

0045098 (Phosphotyrosine protein) phosphatases II 115-350 1.9e-74 245.8 In-house 34-272 (278) alignment
Range on Protein: 115-350
Range on HMM: 34-272/278.0
AMKNRYTNILPTPATRVPlsqigpdalsTYMNANFVDGYnqPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEhtEAPLDTQ
. ||||..||| . .||            | ||...|||  ||.|||||||.|.||.|||||.||....|.||.|.  |.||.||..||||  . .|   
ldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggsltyg

NFQISIASTENMKHYILTKLTLEHR----ASGATRAVSHFWFTNWPDHGVPHET--WEVIDLVKAVRRART-------------DRALPAVVHCSAGIGR
.|.. . |.|....|.|..|....     ... .| | |.....|||||||...  . ...|.. .|.|.              |.  | .||||||.||
dftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgR

TGTFLAVDMGIRSLnnpHRVVDVFGDMIKLRTQRGG-SIQTFVQYLFVHQAMKDYV
|||. |... .. |   ...||..    .||.||.| ..|.. || |..... ...
tGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllell

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 115-351 2e-59 195.9 In-house 47-284 (290) alignment
Range on Protein: 115-351
Range on HMM: 47-284/290.0
AMKNRYTNILPTPATRVPLSQIG--PDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPld
  .||..||...   |..| .|.  .|    |.|| ...||.. |..|||||| ..|. |||...|. .. ..||.| | | |. ||. |||..  .   
kllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..

TQNFQISIASTENMKHYILTKLTLEHRAS-GATRAVSHFWFTNWPDHG-VPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLN
 ..|.| . . |....|| .|| .... | ||.. | .. .|||...| |....  .. . . ..  | .   . |||||...||...|.|....|   .
ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkck

NpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
    |.|||  . ..|.|. ||.|| .|| ...| .  |..
t.egvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld

subfamily_PTPN23_pd Subfamily PTPN23 115-348 2.4e-55 182.4 In-house 44-278 (288) alignment
Range on Protein: 115-348
Range on HMM: 44-278/288.0
AMKNRYTNILPTPATRVPLSqigpDALSTYMNANFVDGYN-QPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDT
. |||...|||   .|| |     .    |.|| || .   .  .|||||.|...|. |||.||.| .|.|.||..   | |. |..|||||.....   
seknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkf

QNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRR----ARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSL
....... |........  .|.||.. . |.. |||  .|.||..|||.   ........|.      .     | |||||||.||||.|  |   .| |
gdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrel

NNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKD
.. . ..|.   . .||.||  ..|.  |. |. .|.  
ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 115-346 1.3e-52 173.4 In-house 4-235 (237) alignment
Range on Protein: 115-346
Range on HMM: 4-235/237.0
AMKNRYTNILPTPATRVPLSQIGPDalSTYMNANFVDGYN-QPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEhTEAPLDT
 .|||| ||     .|| |   | .  | |.||....|..  ||..||.|||   . ||||.|||. .  |.||.||. || ..|||.|||. |. |   
kiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywps.tdqpaay

QNFQISIASTENMKHYILTKLTLEHRAS-GATRAVSHFWFTNWPDHGVPHETWEVIDLVKAV-RRART-DRALPAVVHCSAGIGRTGTFLAVDMGIRSLN
  . .|.   |..  | .  |.| .| .    | .  . || |||.||| .|  .. . | .  |..   .. | ..|||||.|||| || .|  .|  .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

NpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAM
. ..|||..  .  .  .|   |||  ||.|.||..
e.kkvvdiynyvysieedrpyiiqtkdqyvfihqti

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 115-348 9.6e-48 157.5 In-house 34-264 (283) alignment
Range on Protein: 115-348
Range on HMM: 34-264/283.0
AMKNRYTNILPTPATRVPLSQIGPdalsTYMNANFVD---GYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEhtEAPL
  |||. .|.|.   || |    .    .|.|| |.     |.| |..|..|.|  .|| |||.||.. .   .||.| ..|. |||| .|||.  .   
krknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk..rGse

DTQNFQISIASTENMKHYILTKLTLEHRA-SGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLN
|  .| ...      . .|  .|.| . . . .|  ..|. . .| . |       .. . | .   .  .  | |||||.|||||..|.|.   .  . 
dyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdal

NpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKD
  . |||||  .  .| || . .||  || .||... .
t.esvvdvfavvkimreqrmmavqtldqyklvhelvle

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 115-349 7.4e-46 151.6 In-house 42-276 (307) alignment
Range on Protein: 115-349
Range on HMM: 42-276/307.0
AMKNRYTNILPTPATRVPLSQIGpdALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTE--APLD
. ||||...     .|. .   |  . | |. ||..    .|| ||..|||. .|. .|| |. . . | |.|.  . | ..|||..|||          
tdknryqdvkcqdkgrivvkfdg..lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfg

TQNFQISIASTEN--M--KHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTdralPAVVHCSAGIGRTGTFLAVDMGIRS
 ..  ||.|      .   . ..   ||.   .. .|...|. ..||||.|||.     |.|..|||  .     | |||||||.||.|| .|. .    
eapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn....pvvvhcsaGvGrsGtivaislvqdk

LNNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDY
. .     |.   . .||.||  .||| .|||..|. . .|
miaGinckdmkklveelrsqrhyaiqteaqylylhrvlley

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 115-351 2.2e-40 133.3 In-house 49-288 (305) alignment
Range on Protein: 115-351
Range on HMM: 49-288/305.0
AMKNRYTNILPTPATRVPLSQIGPdalSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDT-
| |||| ..      || |    |     |. ||.|    .|| || || |  .|  ||| | .. . | . |.  . | |  ||. |.. . .  |.  
agknrykdvgcldnnrvklegpwp...heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefe

---QNFQISIASTENMKHYI-------LTKLTLEHrASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTdralPAVVHCSAGIGRTGTFLAVD
   |  .. . |....|           |.|..|  . . .| |.|. . .||| |||     ...|..  | ..     | ||||||||||||. . ..
ekgqkisvkfessvtlkfrkdakakvtetvlvieg.pgekarkvthyhwidwpdrgvpaadlailellekarpskg....pivvhcsagigrtgsvvmle

MGIRSLNNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
  .  | . . . |    . |.| ||  ||||  ||||||| . .|. 
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 115-343 4.7e-25 83.3 In-house 20-252 (290) alignment
Range on Protein: 115-343
Range on HMM: 20-252/290.0
AMKNRYTNILpTPATRVPLSQIGPDALSTYMNANFVDgYNQPKEFIATQGPKPET-------VDDFWRMVWEYRSEVVVMMTGIREGGRI----KCHRYW
.|..|... |   ||||.| . |    . |. ||.|  . .  ..|.|| |. ..       . .|| |. . ... |||.    |  .      | .| 
emdqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYv

PEHTEAPLDTQNFQISIASTENMKHYILTKLTLEHRAsGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTdralPAVVHCSAGIGRTGTFLAVD
||. .  |  ......  | |. .  .  .|....   .    | | .. .| .  |...|  ...|.. |.  .|    |..|||  || |  .. |..
pesvgeelkfkgltvkCkskekeddvetRelvvkfdd.eeeftvtHsllkgWnklnvqedtktllsliqkvkaskt....pvivHcvdGiSrsAalaaii

MGIRSLNNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVH
.|   . . .  | .   . .|| ||   |..  .. || 
lgyQkiaetsgsvkledvlkalrkqralaitsalelafvd

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 115-225 6.9e-20 66.0 In-house 48-174 (350) alignment
Range on Protein: 115-225
Range on HMM: 48-174/350.0
AMKNRYTNILPTPATRVPLS--QIGPDA------LSTYMNANFVDGY----NQPKEF--IATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCH
  ||||.||||   .|| |      .||       . |.|||..       ..  .|  ||||.| |.|||||.... .   .|....|   | .. ||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

RYWPEHTEAP--LDTQNFQISIASTEN
|||.| .     .  .. . .|.....
rYWqegsydditvklaskwenimgind

Y_phosphatase Protein-tyrosine phosphatase 116-346 3.1e-76 251.3 Pfam-A 3-233 (235) alignment
Range on Protein: 116-346
Range on HMM: 3-233/235.0
MKNRYTNILPTPATRVPL-SQIGPDAlstYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQ
 ||||..|||   ||| | .. ||     | |||.|.||...|.||||||| ..|..|||||||.....|.||.|   | || ||..||||..| .| ..
kknRykdilpydktrvklkgsegpsd...YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

NFQISIA-STE-NMKHYILTKLTLEHRASG-ATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNN
.... .  ... ..|.|.|.||.|.....  ..| |.....||||||||| .. ...||...|.. ....  | |||||||.||||||.|.|. ...|..
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea

pH-RvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAM
 .   |||.  . .||.|| |..|.. || |...|.
.eee.vdvlqivkelRkqRpgmvqsleqYiflykai

Y_phosphatase Protein-tyrosine phosphatase 116-346 3.1e-76 251.3 In-house 3-233 (235) alignment
Range on Protein: 116-346
Range on HMM: 3-233/235.0
MKNRYTNILPTPATRVPL-SQIGPDAlstYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQ
 ||||..|||   ||| | .. ||     | |||.|.||...|.||||||| ..|..|||||||.....|.||.|   | || ||..||||..| .| ..
kknRykdilpydktrvklkgsegpsd...YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

NFQISIA-STE-NMKHYILTKLTLEHRASG-ATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNN
.... .  ... ..|.|.|.||.|.....  ..| |.....||||||||| .. ...||...|.. ....  | |||||||.||||||.|.|. ...|..
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea

pH-RvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAM
 .   |||.  . .||.|| |..|.. || |...|.
.eee.vdvlqivkelRkqRpgmvqsleqYiflykai

0037934 (Phosphotyrosine protein) phosphatases II 116-349 3.6e-67 221.7 In-house 12-241 (243) alignment
Range on Protein: 116-349
Range on HMM: 12-241/243.0
MKNRYTNILPTPATRVPLsqigPDalSTYMNANFVDGYnqPKeFIATQGPKPETVDD----FWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPehtE-Ap
 ||||..||| . .|| |    ..  | | |||.....  |. .|||||| ||||.|    ||||.||....|.||.|   | ||.||..|||   .   
sknrysdilpydhsrvkl....eg..sdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gev.

lDTQNFQISIASTENMKHYILTKLTLEHRA-SGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRA--------RTDRALPAVVHCSAGIGRTGTFLA
    .|.. . |.|....|....|.||.   .. || | |.....||||||| ..  ..|....||            |.  | .||||||.|||||..|
.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtlia

VDMGIRSLnnphRvVDVFGDMIKLRTQRGG-SIQTFVQYLFVHQAMKDY
 .. .. |    . ||..  . .||.||.| ..||. || |...|.. .
aylmllll....g.vdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 116-355 5.2e-59 194.6 In-house 49-283 (287) alignment
Range on Protein: 116-355
Range on HMM: 49-283/287.0
MKNRYTNILPTPATRVPLSqigpDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEapLDTQN
 |||.|.||.    ||.|     .    |.|| |.|||.. |.||....|  .|. .||..... . ...||..  .|  . .|..||||..   .   .
dknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGe

FQISIASTENMKHYILTKLTLEHRA-SGATRAVSHFWFTNWPDHG-VPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNpH
..|.. . | ...||  || ....  .|... |  . .|||...| |..    .. . . ..  |     . |||||...||...|.|....|.  ..  
yniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckt.e

RVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVTPGNS
 |.|||  . . | |. ||.||  || |. ...  |.. .. 
GviDvfqvlksqriqkpgsvqtveqykfindivleyldsfet

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 116-346 1.5e-51 169.9 In-house 9-236 (239) alignment
Range on Protein: 116-346
Range on HMM: 9-236/239.0
MKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYN-QPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEaplDTQ
 ||||.||.    .|| | ..  |  | |.||...  |.  || .|||||    .  |||||.|. |  |.||.||. || . |||.|||. |       
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts...kyc

NFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNpHR
|.....  || .  ||.  . . .      | | .. || |||.|||. .  |. | . . .     | | |.|||||.||||.|| .|  .|  .. ..
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk.qk

VVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAM
 ||.|  .  .| .|   .||  ||.|.| |.
tvdifnyvkairedrphmvqtseqyvfihlav

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 116-346 1.7e-51 169.7 In-house 10-237 (239) alignment
Range on Protein: 116-346
Range on HMM: 10-237/239.0
MKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYN-QPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEaplDTQ
 ||||.||.    .|| | ..  |  | |.||...  |.  || .|||||    .  |||||.|. |  |.||.||. || . |||.|||. |       
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts...kyc

NFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNpHR
|.....  || .  ||.  . . .      | | .. || |||.|||. .  |. | . . .     | | |.|||||.||||.|| .|  .|  .. ..
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk.qk

VVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAM
 ||.|  .  .| .|   .||  ||.|.| |.
tvdifnyvkairedrphmvqtseqyvfihlav

subfamily_CG7180_pd Subfamily CG7180 116-350 9.5e-48 157.3 In-house 44-290 (296) alignment
Range on Protein: 116-350
Range on HMM: 44-290/296.0
MKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRiKCHRYWPEHTeaPLDTQN
 |||. ...|   .|| |.... .. | |.|| .||.. ..||.| |..|| ||||.|||.|..  .. ||..|   .  . ... |||...    . ..
eknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqyge

FQISIASTENMKHYILTKLTLEHR----------ASGATRAVSHFWFTNWPD-HGVPHETWEVIDLVKAVRRART-----DRALPAVVHCSAGIGRTGTF
. . | ..... .    .. | ..           .  || | .| .| |.  . ||  |  .|.|.. ||  |      .   | ||..| | .|.| .
ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvy

LAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
||.|. .  ... .  ||||. . .|| .| . ...  .| .. . ....|
laidanlelvek.eeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 116-349 1.4e-45 150.2 In-house 58-282 (290) alignment
Range on Protein: 116-349
Range on HMM: 58-282/290.0
MKNRYTNILPTPATRVPLSQIGPdalSTYMNANFVDGYNQPkeFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQN
 |||| ..     ||| |.. ..     |. ||.|.| . .  || |||.  .|| |.|||| . .  ..||.  . | |. ||..|.||.    |   .
kknrykdvvcndktrvilkdGyd...GdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

FQISIA-STENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTdralPAVVHCSAGIGRTGTFLAVDMGIRSLNNPhR
. .  . .... .. |.  |.. .. ||    . |.    |||. |.  |  .. .....|.|      | |||||||||||||| |...|.. | .  .
itvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasG....pvvvhcsaGiGrtGtfvaievglqilldG.k

VVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDY
 .|. . .  ||  | .|.|  .||| . ... |.
eldlldlvralrnsrlnsvqvdiqylalveilldl

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 116-350 1.7e-41 136.9 In-house 57-289 (305) alignment
Range on Protein: 116-350
Range on HMM: 57-289/305.0
MKNRYTNILPTPATRVPLSQIGPdalSTYMNANFVDGYNQP-KEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQ
 ||||...     . | |..  |   | |. ||.|     | | ||..|||  .|.|.|| || . . | .||.    | |..|| .|||      |. .
tknryqdvpcqdqsavkldkpsp...sdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelk

N--FQISIASTENMKHYILTKLT---LEHrASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARtdraLPAVVHCSAGIGRTGTFLAVDMGIRSL
.      .. .  |.     ..|   | . . . . .| |. .|.||| |||      ..|. |.| ..    .| ||||||||||||| .|..  .  .
sgivvenvsgskpmerdaeiqitllnlty.sgdqkmsvrhlqwtewpdrgvppckltslellsairgsk....vpivvhcsagigrtgtivaieyileki

NNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
 . ...  .   .  || ||  |||. |||||.|. | .|.
aenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 116-267 6.1e-37 122.1 In-house 35-186 (297) alignment
Range on Protein: 116-267
Range on HMM: 35-186/297.0
MKNRYTNILPTPATRVPLSQIGPDalSTYMNANFVDGYNQPK--EFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDT
 ||||..|| |  ||| | .  ..  . |.||..|   ....   .| .|||  .||||||..|.|    |.||.. ..|.|| ||  |||.  .  | .
rknryrdilatddtrvkllrvite..rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlka

QNFQISIAST--ENMKHYILTKLTLEHRasGATRAVSHFWFTNWPDHGVPHETWEV
 .. .   |.  .. .. |||.|.| .|    .| | |  | .||||||| .  ..
gdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledl

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 116-350 8.9e-33 108.5 In-house 45-271 (288) alignment
Range on Protein: 116-350
Range on HMM: 45-271/288.0
MKNRYTNILPTPATRVPLSqigpDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDT-Q
 ..||.|.    .||| ||    |    |..|| |   . .. .| .| |   |.. .|.|. |   | .||.. . | |. |   |.| .        .
trdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigr

NFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVrrarTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHr
. ..   . ..... .   |   ..    .  | .  . .|.|.|||..    . |.. .     .   | |||.|||.|||||.  . . ..||  .  
lctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialeslrldd.

VVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
 . .   . ||| .|  .|||  |||.||. .....
flgirsllaklreerfkaiqtemqylyvhrcvleel

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 116-347 3.6e-30 99.6 In-house 54-287 (310) alignment
Range on Protein: 116-347
Range on HMM: 54-287/310.0
MKNRYTNILPTPATRVPLsQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEH----TEAPL
 ||||....   ..|| | .|       |. ||.|      . || .|||   |. |||||... |.| ....  . | || ||  |||      |   .
hknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygci

DTQNFQISIASTENMK---HYILTKLTL-EHRASGATRAVSHFWFTNWPDHGVPHETWEVIDlvkaVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIR
   |.  |    |  .    ..  .. . |  |      ||   . |||| ||| |    .      |     |  | |||||||..|... .|... | 
rvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp....qrllaqvrhgpcvvhcsagkdrlyvvvalklkid

SLNNPHRvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMK
 |.. .. ||.   . .|. .|   ||| .|||.... . 
kldrglk.vdaeevktellksraiciqtelqyliidrvri

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 116-351 5e-16 53.2 In-house 49-280 (303) alignment
Range on Protein: 116-351
Range on HMM: 49-280/303.0
MKNRYTNILPTPATRVPLSQigpdalSTYMNANFVDgYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEApLDTQN
 |||.....    ..| ||.      |.|. |....  .  |  | || | . |  |||.|. | .  .|...    |  ..  .  .|.  .  |. ..
dknrfvdvicldhskvklsd......ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf.lkfee

FQISIAS---TENMKHYILTKLTLehrASGATRAVSHF-WFTNWPDHGVPHE----TWEVIDLVKAVRRARTDrALPAVVHCSAGIGRTGTFLAVDMGIR
  | .      | .. . |  |..   . |  ..  |   . .||   .| .        |  ...| |  .| . |.|    .| ||.|||   .    
rsirvgefkrvelgdgwvlkvlsv...sngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysd.stptvymslsgcgragtfalfetahl

SLNNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
|| .    .|.   . ..|  |  ..| . |. .|.  . ..| 
slhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 116-207 8.1e-12 39.1 In-house 50-157 (349) alignment
Range on Protein: 116-207
Range on HMM: 50-157/349.0
MKNRYTNILPTPATRVPLSQIG--------------PDALSTYMNANFVD--GYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKC
 |||| .|||   .|| | .                   |  |.|||..    ..  | .|||| | | |||||....   . ..|. ..   | .  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HRYWPEHT
..|| | .
diywqels

0042113 (Phosphotyrosine protein) phosphatases II 117-350 9.2e-75 246.5 In-house 12-243 (245) alignment
Range on Protein: 117-350
Range on HMM: 12-243/245.0
KNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEhtEAPLDTQNF
||||..||| . ||| || .|.|  |.| ||..||||.... ||||||| ||||.|||||.||......||.|   | ||.||..|||.  . .| . .|
knrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..gesltygdf

QISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRART-DRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPhRV
..   |.|....|....|....  .. .| | |.....|||||||. .  ..|....||.|.  |.  | .||||||.||||||.|... .. |.   . 
tvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqleke.lg

VDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
|...  . .|| ||.|..||. || |...|.....
vsleeavkelrsqRpgavqtpsqyrflyeallell

0040439 (Phosphotyrosine protein) phosphatases II 117-350 1e-74 246.5 In-house 14-246 (249) alignment
Range on Protein: 117-350
Range on HMM: 14-246/249.0
KNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEhtEAPLDTQNF
||||..||| . .|| || ..   || | ||...|||.....||||||| ||||.|||||.||....|.||.|   | ||.||..|||.  . .|   .|
knrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggsleygdf

QISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTD--RALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHR
..   |.| ...|....|.|..   | .| | |...|.|||||||  . ...|...||| |...  .  | .||||||.||||||.| .. .. |.  ..
tvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelg

vVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
 ||..  . .||.||.|..|.. || |...|.....
.vdleeavkllrsqRpgavqnpeqyrflyeallell

0041856 (Phosphotyrosine protein) phosphatases II 117-350 4.4e-46 152.1 In-house 4-171 (182) alignment
Range on Protein: 117-350
Range on HMM: 4-171/182.0
KNRYTNILPTPATRvplsqigpdaLSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTgireggrikCHRYWPehteapldtqnf
||||..||| . .|           ..| |||...|.  ...||||||| ..|| ||.||..|..  ..|..|         ...|||            
knrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp............

qisiastenmkhyiltkltlehraSGATRAVSHFWFTNWPDHGVPHeTWEVIDLVKAVRRartdRALPAVVHCSAGIGRTGTFLAVDMGIRSlnnphRvV
                        .  .|.. ......|||||||  . |..|....|..    .  | .||||||.|||||. | .. ..      . |
........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....g.v

DVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
...  .  .| .| |...|  || |...|. ...
sleeavklvrsrRpgmvitpnqyfflqlallell

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 117-342 2.7e-38 126.4 In-house 53-273 (301) alignment
Range on Protein: 117-342
Range on HMM: 53-273/301.0
KNRYTNILPTPATRVPLSQigpDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQNF
|.|| ..   | | | . .   |     . ||...   .|. ||||||| ..| .||| |.  |  | .||..  .|    ||. | | ...  || . |
khryptvPckPstaveviv...dGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrf

QISIASTENMKHYILTKLTLEHRASG---ATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTdralPAVVHCSAGIGRTGTFLAVDMGIRSLNNpH
.| | ..| . .  ..| ||| . |    |||.| |. ...|.|.|||.   |. ||.. |....     | ||||||||||. .|.. ..  | ... .
kikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek....PivvhcsaGiGrsvafigteylarevea.d

RVVDVFGDMIKLRTQRGGSIQTFVQYLFV
. ...   . .|| .|  ..||  |  ..
ptieltealkhlrehrwngvqtnsqlywm

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 118-350 7.9e-32 105.4 In-house 39-270 (285) alignment
Range on Protein: 118-350
Range on HMM: 39-270/285.0
NRYTNILPTPATRVPLSQIGPDalstYMNANF--VDGYNQpKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQN
|||...     ||| | .   |    |. |..  . | .|   .|.|||| |||. |||.|... .   |.|.  . |||  ||  |.||.    .   .
nryadvrcieetrvvlknhdrd....yihaswmrmpgkdq.styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgk

FQISIAS--TENMKHYILTKLTLEH--RASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTdRALPAVVHCSAGIGRTGTFLAVDM-GIRSLN
..|...    | .   ||  ||.     ||     . |     |||.  | ..  .|.| | |..    .  | .||||||.||| ||. .|   || ..
yeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp.kekpicvhcsagvgrtatfvgidyatirime

NPH-RVVDVFGDMIKLRTQrggSIQTFVQYLFVHQAMKDYV
||   ..|.  .|  .| |   ..|...|.||..  . .|.
npniemldivremramrfq...avqshmqflflyvvlmeyf

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 118-350 3e-30 100.0 In-house 47-276 (312) alignment
Range on Protein: 118-350
Range on HMM: 47-276/312.0
NRYTNILPTPATRVPLSqiGPDalSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTE---------
||| ||      |  |.  | .    |. ||||    .|. |..||||  .|.  ||...    |  .....|. | |  || .|  .            
nrypniqcwdrgrftla..gde..nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

APLDTQNFQISIASTENMKHYILtklTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTdralPAVVHCSAGIGRTGTFLAVDMGIRS
      . .|   | ... | .|    .  .|.|    . |. .. |||||.|        |. ||.. .     | . |||||.|||||.  ..  | .
yteycteieiggkskdkithrvl...kvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk....pviahcsagvgrtgtlaliesmiaa

LNNPHRvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
|  | .  .|   .. || .|  |...| ||... ... ...
lrhprk.qnvkdsfvllrkdrarsvrvfpqyvyalrcvlefl

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 123-186 2.4e-09 31.2 In-house 46-114 (347) alignment
Range on Protein: 123-186
Range on HMM: 46-114/347.0
ILPTPATRVPLS----QI-GPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVV
   . |||| ||    .    |   ||.||  .   |  ||.| || | |.|| |||.||   .   ||
vklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv

subfamily_egg_pd Subfamily egg 125-346 3.9e-27 89.7 In-house 51-266 (307) alignment
Range on Protein: 125-346
Range on HMM: 51-266/307.0
PTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGgrIKCHRYWPEHTEAPLDT--QNFQISIAS
    .|| |       |  .. || |.|     ||| .| |  .|||||||||.. . . .||.|  .|    .|. |||   . .| |   ...|    
ckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlk

TENMKH--YILTKLTLeHRASGATRAVSHfWFTNWPDHGVPHETWEVIdlvkavRRARtDRALPAVVHCSAGIGRTGTFLAVDMGIRSL-NNPHRVVDVF
 ..     . .||| |   .    | . | |  ..   .  .   .|.      |..| . . |.||..  |. ...|..|... . ||   |     | 
vdskadplfrvtklkl.vGgddeerfleh.wqgdvnnssdvysplrvl......rklr.nlskpvvvqdilGvskaatlvaieiallsllrGpitkslvl

GDMIKLRTQRGGSIQTFVQYLFVHQAM
  .  || .|  |... ..||||.. .
ravvflrlrrrlsvesvllylfvyrlv

0044763 (Phosphotyrosine protein) phosphatases II 126-347 6.2e-29 96.3 In-house 2-168 (178) alignment
Range on Protein: 126-347
Range on HMM: 2-168/178.0
TPATRVPLSQIGPDALSTYMNANFVDGYnqpkEFIATQGPkpetvDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEapldtqnfqisiasten
 . ||| || .     | |.||......     ......|      |......|.   ..|..|.  |.|..||..|||| ..                 
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

mkhyiltkltlehrasgatravSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSlnnphRVvDVFGDMIKL
                       .. ....||||||  .. . ..|.....|. ..  | .||||||.||.||. | .. ..      .. ...  .  .
......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....gl.sleeaielv

RTQRGgSIQTFVQYLFVHQAMK
| .|   .... |. ....  .
rerRp.ivpnpgqlrqLyefel

0046846 (Phosphotyrosine protein) phosphatases II 135-349 1.7e-42 140.5 In-house 5-172 (176) alignment
Range on Protein: 135-349
Range on HMM: 5-172/176.0
QIGPDALSTYMNANFVDGYnqpkEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLdtqnfqisiastenmkhyiltkl
..|.|  ..| |||...|.     .|||||| |.|. ||..|..|.. ..||..|  .| ||.||..|||| ... .                       
llgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

tlehrasgatravsHFWFTNWPDHGVPHEtWEVIDLVKAVRRARTDRaLPAVVHCSAGIGRTGTFLAVDMGIRslnnpHRVVDVFGDMIKLRTQRG-GSI
              ......|||||||     ...|....|.|...   | .||||||||||||..| .. ..     .. ..|.  . ..| ||  |..
..............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel.....ekglsveealalvreqRplgav

QTFVQYLFVHQAMKDY
||. || |...... .
qtpeQyrflyefelll

0051429 (Phosphotyrosine protein) phosphatases II 141-351 3.4e-50 166.5 In-house 3-226 (272) alignment
Range on Protein: 141-351
Range on HMM: 3-226/272.0
LSTYMNANFVDGYNQ---PKEFIATQGPKPETVDDFWRMvWEYRSEVVVMMTGIREGGRIKCHRYWP----------EHTEAPLDTQNFQISIASTENMK
||.| ||..|.||..   |. .....|| | |..||||. .|..  ..|....  | || ||.||||          .... .    .. . . |.|.. 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

HYILTKLTLEHR-ASGATRAVSHFWFTNWPDHGVPHETweVIDLVKAVRRartdrALPAVVHCSAGIGRTGTFLAVDMGIrSLNNPHRVVD--------V
.|||..|.|..    |..| | |...|.|||||||.|.  ...|......       | .||||||..||||. |... .    . . .||        .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyl

FGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
.. . .|| || |..||  ||||...|..... 
eeaveelraqrpgavqteeqylflyeallellr

0043147 (Phosphotyrosine protein) phosphatases II 141-345 4e-42 139.2 In-house 4-156 (172) alignment
Range on Protein: 141-345
Range on HMM: 4-156/172.0
LSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIreggrikchrywpehteapldtqnfqisiastenmkhyiltkltlEHRA
 |.|.||...|.|  |..||||||| ..|..|||||..|.   ..|..|.                                              .. .
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lydp

SGATRAVSHFWFTNWPDHGVPhETWEVIDLVKAVRR-ARTDRALPAVVHCSAGIGRTGTFLAVDMGIrslnnphRVVDVFGDMIKLRTQRGGSIQTFVQY
.. .| . ......|||||||  .  ...... ... .  ..  | .||||||.|||||. | .. .       . ....  .  .|..|.|..|.. ||
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqnpsqy

LFVHQA
 |... 
rflyyf

0051082 (Phosphotyrosine protein) phosphatases II 141-345 2.4e-33 110.2 In-house 2-148 (151) alignment
Range on Protein: 141-345
Range on HMM: 2-148/151.0
LSTYMNANFVDGYnqpkeFIATQGPKPetvdDFWRMVWEYRSEVVVMMTGIREGGriKCHRYWPEHTeapldtqnfqisiastenmkhyiltkltlehra
||.| |...|.|.     .....|| .    ||.....|.   ..|....  | |  .|..|.||.                                  
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

sgatRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRartDRALPAVVHCSAGIGRTGTFLAVDMGIRSlnnphrvVDVFGDMIKLRTQRGGSIQTFVQYL
    . | |.....|||.|.|. . .|.........   ..  | .||||||.|||||. |... ..        |...  .  .| .|.|..|.. |.|
....ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqfl

FVHQA
|...|
fqlfa

0036282 (Phosphotyrosine protein) phosphatases II 142-344 1.8e-45 150.1 In-house 2-164 (174) alignment
Range on Protein: 142-344
Range on HMM: 2-164/174.0
STYMNANFVDGYNQPKEFIATQGPKPetvddFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEhteapldtqnfqisiastenmkhyiltkltlehRAS
|.|.||...|..  ....||.||| .     ||.|..|.....|||..  .| |. ||..||||                                 . .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

GATRAVSHFWFTNWPDHGVPHETWeVIDLVKAVRRARTD-RALPAVVHCSAGIGRTGTFLAVDMGIRSLNnpHRVVDVFGDMIKLRTQRGGSIQTFVQYL
  .| . ......|||||||  .  ....||.|..|. . .  | .||||||.|||||. | .. .| |   ...||..  . .||.||.|..||. || 
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtpsQyr

FVHQ
|...
flyy

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 142-260 2e-12 41.6 In-house 13-126 (130) alignment
Range on Protein: 142-260
Range on HMM: 13-126/130.0
STYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGgrikcHRYWPEHteAPLDT--QNFQISIASTENMKHYILTKLTLEHR
 ||.||.||   .. .|.. || |  .|  |||.|. |   .|.|..  . |        |||.    ||.   ..  ....  ...|.   ..|  |. 
ntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpds..ePlewyeediivtltdrdefknikasnleiesd

ASGATRAVSHFWFTNWPDHGV
   . .|.. |  .|||  | 
lneshqaltmfqisnwpsdgt

subfamily_eak_pd Subfamily eak 142-262 4.2e-12 40.1 In-house 78-196 (332) alignment
Range on Protein: 142-262
Range on HMM: 78-196/332.0
STYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQNFQISIASTenMKHYILTKLTLEHRAS
  |.||  ..  .  ...| |  .. . |  ||.|| | .|  .|..    | .  |  .|.|..|   |.   ...   .   .|. ||    || .  
lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkef..vkrniletrllelskG

GATRAVSHFWFTNWPDHGVPH
  |  | |. .  | .  .| 
nethrvlhykvfGwtettlpk

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 144-350 1.4e-18 61.3 In-house 77-285 (302) alignment
Range on Protein: 144-350
Range on HMM: 77-285/302.0
YMNANFVDGYNQPKEFIATQGPKPETV---DDFWRMVWEYRSEVVVMMTGIREGGRiKCHRYWPEHTEAPLDTQNFQISIASTENMKHYIlTKLTLEHRA
|.||  |.  .  .. | .| || ...   ..|||||.. .   ||.. |  |  .   . ..|..... .. ... . .   |...    |....|   
yvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlP

SGATRAVS--HFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPhRVVDVFGDMIKLRTQRGGSIQTFVQ
 | . .|      .|||... || .  |.|  .. |    ..   ..|.    |.|| |.||.. . . .|..    . .   ....|.||  ..... |
egcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkg.kepnikeivksiRsqRpravdslkQ

YLFVHQAMKDYV
| ... |.  |.
yvslyialllyi

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 145-342 7.5e-25 82.0 In-house 78-280 (302) alignment
Range on Protein: 145-342
Range on HMM: 78-280/302.0
MNANFVDGYNQPKEFIA-TQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQNFQISIAST-ENMKHYIL----TKLTLEH
|    .|| .. ..       || .|.. .| .. .|.  .|| .... |..  ||  |. .. .  |  ... .   |  ......      .  |.| 
maqGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytvei

R----ASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDralpAVVHCSAGIGRTGTFLAVDMGIRsLNNPHRVVDVFGDMIKLRTQRGGSIQ
.     .   ..|. . |. ||||| |.|.   .|..|     ...     .||||||.|||||..|.  ||  |   ..| |.   .. .|. | |..|
knekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiq.lcskkkvtdllsivlpvrqcryGavq

TFVQYLFV
.  | ...
deqqliyl

0049260 (Phosphotyrosine protein) phosphatases II 149-344 8.5e-40 131.3 In-house 1-144 (152) alignment
Range on Protein: 149-344
Range on HMM: 1-144/152.0
FVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWpehteapldtqnfqisiastenmkhyiltkltlehrasgatravs
|.|||..|.|||||||| |.|..|||||..|.   ..||.|   | |..||..|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

HFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIrslnnphRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQ
.. ...|||||||  .  ...|........ |.  | .||||||.|||||. | .. .       . |...  .  .|..| |..... |. |...
qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 151-237 1.5e-10 35.0 In-house 230-312 (440) alignment
Range on Protein: 151-237
Range on HMM: 230-312/440.0
DGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGgriKCHRYWPEHTEApLDTQNFQISIASTENMKHYILTKLTLE
.|| . . ||||| |   || ||||.| .||   ..|.  . .     |  |||  | . .    | .    .|||.   .  | | 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrs.vtfgpftvghkgsenmnrvkvrtlelk

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 157-344 1.2e-28 94.7 In-house 5-198 (199) alignment
Range on Protein: 157-344
Range on HMM: 5-198/199.0
KEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQNFQISIASTENMKHYILTKLTLE--HRASGATRAVSHFWFTN
. .|||| |  ||. |||.||||  |  .||.   .         |||    .     .. ..  .      | .| | |     |  .|| .||. || 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPHETWEViDLVKAVR----RARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPH-RVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQ
| ..  |  .  |  .| | |    .   ..  | .|||| | | || |.|.|.|.|| .. .  |||.|    .||  | | | .. .| |..|
wkekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 157-344 1.2e-28 94.6 In-house 4-197 (198) alignment
Range on Protein: 157-344
Range on HMM: 4-197/198.0
KEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQNFQISIASTENMKHYILTKLTLE--HRASGATRAVSHFWFTN
. .|||| |  ||. |||.||||  |  .||.   .         |||    .     .. ..  .      | .| | |     |  .|| .||. || 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPHETWEViDLVKAVR----RARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPH-RVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQ
| ..  |  .  |  .| | |    .   ..  | .|||| | | || |.|.|.|.|| .. .  |||.|    .||  | | | .. .| |..|
wkekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 169-355 1.9e-24 81.2 In-house 40-226 (255) alignment
Range on Protein: 169-355
Range on HMM: 40-226/255.0
TVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQNfqISIASTENMKHYILTKLTLEHRAS--GATRAVSHFWFTNWPDHGVPHETWE
||| |....   ..|||||..   | |. ||..|.|   .  |  ..  .....|... . .|  |..    .    |. | |. .. |...  |... |
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklklad..vnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

VIDLVKAVRRARtdralPAVVHCSAGIGRTGTFLAVDMG----IRSLNNPHRVVDVFGDM-IKLRTQRGGSIQTFVQYLFVHQAMKDYVTPGNS
.  ..|.|| ..     . |||||.||||. .|  ...     ||||.. . |   .  .  .|| .| ..|.| .|  |    . |.| | . 
ilnilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkge

subfamily_hpo-7_pd Subfamily hpo-7 169-354 2e-20 67.8 In-house 46-231 (263) alignment
Range on Protein: 169-354
Range on HMM: 46-231/263.0
TVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQNfqISIASTENMKHYILTKLTLEHRA--SGATRAVSHFWFTNWPDHGVPHETWE
|.| |....   ..|||||..   | |. || .|.|   .  .  .|  .....|. ..  .|  | |         |. | |. .. |...  |... |
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklan..vnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelare

VIDLVKAVRRARtdralPAVVHCSAGIGRTGTFLAVDM----GIRSLNNPHRVVDVFGDMI-KLRTQRGGSIQTFVQYLFVHQAMKDYVTPGN
.. ..|..|  .     . |||||.||||.  |  ...     ||||.. . |   .  .. .|| .| ..|.| .|  |    . |.| . .
ilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnf

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 169-351 2.4e-07 23.7 In-house 130-310 (346) alignment
Range on Protein: 169-351
Range on HMM: 130-310/346.0
TVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQNFQIS--IASTENMKHYILTKLTlEHRASGATRAVSHfwFTNWPDHGVPHETWE
 |.||| |... . ..| .|             .  |        . |        . . | | .  |  |  .      | |   . |     |  |  
fvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlp.egnsdsvicqvhh..hapwkhlqqppktlp

VIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHRvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
.| ...     .  ...   |    | ||. .|.     |. |||     ...  | ... || |....| ||  ..  . ||..
iikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngie.pniceimknikqqrpggvesfaqyasiyaivfdyia

0038934 (Phosphotyrosine protein) phosphatases II 218-342 8.9e-09 30.8 In-house 47-169 (194) alignment
Range on Protein: 218-342
Range on HMM: 47-169/194.0
ISIASTENMKHYILTKLTLEHRA---SGATRAVSHFWFTNWPDHGVP---HETWEVIDLVKAVRRARTDRalPAVVHCSAGIGRTGTFLAVDMGIRSLNN
..  .. |.|.. .  || ..|    .  ..|  ..    .||.|..     ... .|||. . .. ..     .||| ||.|||||..|  .  |   .
vrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpgg..vvaVHCkaGlgRtGtlvaaYLiyrlgms

PHRVVDVFgdmiklRTQRGGSIQTFVQYLFV
..  .. |      |  |.|.|..  ..  .
aeeAialf......rekRpgaipnqdyleal

0048179 (Phosphotyrosine protein) phosphatases II 220-344 5.2e-21 70.3 In-house 22-139 (144) alignment
Range on Protein: 220-344
Range on HMM: 22-139/144.0
IASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRaLPAVVHCSAGIGRTGTFLAVDMGIrslnnpH-RvVDV
..   ..... .  || |.     .| . ......|||||||  .  ..........|. .   | .||||||.|||||. | .. .      . . ...
lellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk......klg.lsl

FGDMIKLRTQRGGSIQTFVQYLFVHQ
.  .  .|..| |..... |. |...
eealalvrsrrpgavpnpgqlrfLle

0048076 (Phosphotyrosine protein) phosphatases II 223-348 1.2e-22 75.5 In-house 23-141 (145) alignment
Range on Protein: 223-348
Range on HMM: 23-141/145.0
TENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRaLPAVVHCSAGIGRTGTFLAVDMGIRslnnpHRvVDVFGDM
 .  .. | | |.| .  .. .| . ......|||||||  .  ..........|. .   | .||||||.|||||. | .. ..     .. |...  .
ellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lg.vsleeal

IKLRTQRGGSIQTFVQYLFVHQAMKD
 ..|.|| |..... |. |.... . 
elvrsqrpgavpnpgqlrflyefele

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 244-364 2.3e-16 54.2 In-house 88-208 (440) alignment
Range on Protein: 244-364
Range on HMM: 88-208/440.0
TRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTD-RALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHRvVDVFGDMIKLRTQRGGSIQTFVQYLFV
.|.. .. .  |||.|||. .  |. ... |  ..      | .|||||| ||||  .|||  .|  .   . .|.|  .  .| .|   .||  || ||
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdq.idifsfinsmrnnrpqmvqtpeqyafv

HQAMKDYVTPGNSFGMFGDNTS
|.|. . .  |... .  | | 
heavlegllcgdtlileddite

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 244-350 2.9e-13 44.3 In-house 214-344 (350) alignment
Range on Protein: 244-350
Range on HMM: 214-344/350.0
TRAVSHFWFTNWPDHGVPHETWE----------VIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIR------SLNNPHRVVDVF---GDMI-
   | .. . ||.| ..  .  .          .||   |     ..|. | .||||||.|||||....|. .        |..  | .||     |.| 
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlis

----KLRTQRGGSIQTFVQYLFVHQAMKDYV
    .|| ||   .|.  |..|...|.. | 
iivnelrkqrismvqnldqfifiYeallfyf

PTPc_DSPc_SM00012 247-347 1.1e-31 104.6 In-house 2-104 (105) alignment
Range on Protein: 247-347
Range on HMM: 2-104/105.0
VSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRA--LPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQ
|.|...|.|||||||.|. ....|..||.. .....   | |||||||.|||||| |.|. ...|.. .. ||.|  . .||.|| |..||. ||||...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AMK
|..
all

subfamily_PTPDC1_pd Subfamily PTPDC1 250-346 1.5e-08 29.3 In-house 85-172 (182) alignment
Range on Protein: 250-346
Range on HMM: 85-172/182.0
FWFTNWPDHGVPHETwEVIDLVKAVRRARTDRalPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHRVVDvfgdmiKLRTQRGGSIQTFVQYLFVHQAM
..   |.|.||.  . ...|.|| |  | ..      ||| || ||||  .|. .   .  .... ..      ..| .|  ||||  |  .|.. .
vynfgwkDygvasle.riLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltaekaik......lvrskrpksiqtreqvelvkefa

subfamily_DSP23_pd Subfamily DSP23 263-344 3.8e-06 21.6 In-house 66-140 (148) alignment
Range on Protein: 263-344
Range on HMM: 66-140/148.0
ETWEVIDLVKAVRRARtDRALPAVVHCSAGIGRTGTFLAVDMgIRslnnpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQ
   .| ..|. |  |  ...    |||  | |||||.||  . ..     .| .     . ..| .| ||..|. |   |..
aleqvvefvrvveeae.ekneavsvhcllgrgrtgtmlacyl.vk.....erklaaaeaiaevrrlrpgsvetveqeklvrd

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 266-310 1.6e-07 25.0 In-house 249-293 (349) alignment
Range on Protein: 266-310
Range on HMM: 249-293/349.0
EVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLN
..||   |     ||.  . .|||||| ||||..  .|. .  |.
dliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsile

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 276-346 6.6e-11 36.6 In-house 222-291 (297) alignment
Range on Protein: 276-346
Range on HMM: 222-291/297.0
RARTDRALPAVVHCSAGIGRTGTFLAVdMGIRSLNNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAM
||   | .. .||||||.||.|  .   . | .    .|. ||   . .|| ||   .||. |. ....|.
raemprnayllvhcsaGvGrsGvvvls.dvilaklrkkripdvaailsilreqrarlvqtleqfellydav

subfamily_CG42327_pd Subfamily CG42327 278-349 5.5e-17 56.4 In-house 243-314 (319) alignment
Range on Protein: 278-349
Range on HMM: 243-314/319.0
RTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDY
. ..  | ||||| |.||||. .| |. ||||....| ||.   .  .| .|. ...|  || |... .  |
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 286-347 2.3e-10 34.7 In-house 2-62 (69) alignment
Range on Protein: 286-347
Range on HMM: 2-62/69.0
VVHCSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMK
|||||.| ||||||.|. . .  .    ..||.| ..  .|  |   .   ..|.|.| |. 
vvhcssgtgrtgtfiaimvemariks.eklvdifnnvqymrkcrpmmvmneieyifihdalv

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 286-348 8e-10 32.9 In-house 1-62 (69) alignment
Range on Protein: 286-348
Range on HMM: 1-62/69.0
VVHCSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKD
|||||.| ||||||.|. . .  .    ..||.| ..  .|  |   .    .|.|.|.|. .
vvhcssGtGrtGtfiaimvemariks.eklvdifnnvqymrkcrpmmvmneneymfihdalve

PDZ_2 PDZ domain 365-413 1.8e-06 17.4 Pfam-A 28-76 (82) alignment
Range on Protein: 365-413
Range on HMM: 28-76/82.0
RDVGVLPGDQILAINQQPVHNLKHAEVAERARQSGGVITLTLLSKKLEE
 . |. |||.||......|..|.. . . .  . |  ..||.| .. ..
akaglkpGDiilkvdgkkvksltdlkslllkkkpGdtvkltvlRdgkkk

PDZ PDZ domain (Also known as DHR or GLGF) 369-406 6.1e-10 29.3 Pfam-A 43-80 (81) alignment
Range on Protein: 369-406
Range on HMM: 43-80/81.0
VLPGDQILAINQQPVHNLKHAEVAERARQSGGVITLTL
. .||.||..|...| |. |.|...  ....|..|||.
lkeGDkIlsvNgvdvenvshdeavqaikgkkgevtLti