Gene MbrePTP-Un-8 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP062_AA protein Get Run
MbreP062_AA_73-351 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 72-350 6.7e-90 296.8 In-house 25-299 (308) alignment 
Range on Protein: 72-350
Range on HMM: 25-299/308.0
RSRPMDVLALHEALRDREMLEEEFERAPHMLVGPD-TLPNDPRVAMKNRYTNILPTPATRVPLsqigpDALSTYMNANFVDGY--NQPKEFIATQGPKPE
. . .|.| |.| . |. .||||||. ... . .. .  . |.   ||||..|||   .|| |     |  |.| ||..||||  ..|..|||||||.|.
klsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpn

TVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTE-APLDTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEV
||.||||||||....|.||.| . | ||.||..|||. ..  .|   .|.. . |.|....|....|.|..  .| .| | ||..|||||||||... ..
tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeil

IDLVKAVRRARtdRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPhRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
.|....||. .  .  | |||||||.||||||.|.|. .. |.   . ||||. . |||.|| |..||. ||||...|. .|.
ldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleyl
0039614 (Phosphotyrosine protein) phosphatases II 74-350 7.5e-81 267.1 In-house 17-289 (297) alignment 
Range on Protein: 74-350
Range on HMM: 17-289/297.0
RPMDVLALHEALRDREMLEEEFERAPHMLVGpDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGP-DALSTYMNANFVDGYNQ-PKEFIATQGPKPETVD
. .|.| |.| . .. .|..|||. . . .   .  . |    ||||..||| . .|| |. ..  |  |.| ||..||||.. ...||||||| ||||.
svldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetve

DFWRMVWEYRSEVVVMMTGIREGGRiKCHRYWPEHTEaplDTQNFQISIASTENMKHYILTKLTLEHraSGATRAVSHFWFTNWPDHGVPHETWEVIDLV
||||||||....|.||.|   | || ||..|||| ..      .|..   ..|  ..|....|....  .| .| | ||..|.|||||||. .  .....
dFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllefl

KAVRRARTD--RALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPhRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
..||.|.    .  | .||||||.||||||.| .. .. |.   . |||.  . .|| ||.|..||. || |...|.....
elvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallell
0045450 (Phosphotyrosine protein) phosphatases II 74-350 1.4e-80 266.6 In-house 12-304 (307) alignment 
Range on Protein: 74-350
Range on HMM: 12-304/307.0
RPMDVLALHEALRDREMLEEEFERAPHMLV---GPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPD-ALSTYMNANFV--------DGYNQPKEFIA
.... | | . | ... |..|||. ... |   |. .  . |    ||||..||| . ||| || ....   | | ||..|        |||.....|||
lkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIa

TQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHtEAPLDTQNFQISIASTENMKHYILTKLTLEHR-ASGATRAVSHFWFTNWPDHGV
||||.||||.|||||.||....|.||.|.  | ||.||..|||.  . .|   ||..   |.| ...|....|....   .| .| | ||..|.||||||
tqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgv

PHETWEVIDLVKAVRRARTD--RALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHRV--VDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
|  . |..|....||.|. .  .  | .||||||.||||||.| .. .| |.. . .  ||..  . .|| ||.|..|.. || |...|.....
ppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 80-351 4.7e-58 191.7 In-house 17-285 (297) alignment 
Range on Protein: 80-351
Range on HMM: 17-285/297.0
ALHEALRDREMLEEEFERAPHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQpkEFIATQGPKPETVDDFWRMVWE
.| .  |. .. .|||   |.  . |.|  ..     |.||.||||.   || |  .. |  | |.|| || |...  ..|.|| |...||.|||.||..
tlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvld

YRSEVVVMMTGIREGGRiKCHRYWPEHTEAPldTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPH--ETWEVIDLVKAVRRA
..  ..||..   |. . || |||.... ..    .  . . |... . .|  .|.... .. |.| |  . |..|||. |..  ..  ...|.. ||  
eqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkd

RTDRAL-PAVVHCSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
  ..|  | .|||.||.|||| .|..|  .   .. .  ||.|| . ||| .|   .||  || ||..|. ... 
fsqnaegPllvhclaGvGrtgvlltidsvvaeakr.ekevdifglvkklrqerpylvqtkeqykfvyvavleall
0036941 (Phosphotyrosine protein) phosphatases II 81-350 1.8e-84 278.9 In-house 5-277 (297) alignment 
Range on Protein: 81-350
Range on HMM: 5-277/297.0
LHEALRDREMLEEEFERAPHMLVGPD-TLPNDPRVAMKNRYTNILPTPATRVPLsqigPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWE
| | | .. .|..|||. ...|. .. .  . |.   ||||..||| . ||| |    .|  | | ||..||||.....|||||||.|.||.||||||||
llekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

YRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQNFQISIASTEN--MKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRA
....|.||.|   | ||.||..|||. .. .|   .|..   |.|    ..|.|..|....  .| .| | ||..|.|||||||. . ...|....||..
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkv

RTD--RALPAVVHCSAGIGRTGTFLAVDMGIRSLNN--PHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
.    .  | .||||||.||.|||.|.|. .. |..   .. ||..  . |||.|| |..||. ||.|...|. ...
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
subfamily_PTPN14_pd Subfamily PTPN14 81-350 8.6e-57 187.4 In-house 16-296 (300) alignment 
Range on Protein: 81-350
Range on HMM: 16-296/300.0
LHEALRDReMLEEEFERAPHMLVGPDTL-PNDPRVAMKNRYTNILPTPATRVPLSQIGpDALSTYMNANFVDGY--NQPKEFIATQGPKPETVDDFWRMV
|.. |..  ..  |.|| |..    ..   . |  | |||. ..||   .|| ||    .. . |.||  .      . ...|..||| . || |||.||
lekkleeg.kvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptk.enstgyinassikvsvggkersyivaqgPleltvqdfWqmv

WEYRSEVVVMMTGIREGGRIKCHRYWPEH--TEAPLDTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVID---LVK
||   ...||.| ..|.|. |...|.|..   .  .. ..|...   .|. . .| |.|.|.|  |.  | | |. .|.|||||||..  . ..    |.
WeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevq

AVRRARTDRA------LPAVVHCSAGIGRTGTFLAVDMGIRSLNNPhRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
.|||. ..         | .||||||.||||  . .|. | .|..  ...|.   . .||.||   .||. || ||....  |.
svrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehn.eeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_PTPRN_pd Subfamily PTPRN 81-350 5.3e-47 155.0 In-house 21-292 (297) alignment 
Range on Protein: 81-350
Range on HMM: 21-292/297.0
LHEALRDREMLEEEFERAPHMLVGPDTL--PNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDG-YNQPKEFIATQGPKPETVDDFWRMV
|.. |.... ||.|.|   .    | |    ...... |||....||   .|| |..   .  | |.|| ..     .   .|||||| ..|| |||.||
ledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmv

WEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLdtQNFQISIASTE-NMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRR
||  . |.|..| ..| |  .|.||||.. ..    . ... . |     . |..  . |    .  ||.|. | |  ||..||| ..  .... . | .
weqGvvvivnltrleeegvkqckrywpdeGsevy..hiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnk

ARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
.   |. | |||||.| ||||.....|. .  |..  . .|.   . .|| || | ..|  |. |. .|. . |
syrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
0047943 (Phosphotyrosine protein) phosphatases II 82-350 1.5e-83 275.7 In-house 5-272 (273) alignment 
Range on Protein: 82-350
Range on HMM: 5-272/273.0
HEALRDREMLEEEFERAPHMLVGPD-TLPNDPRVAMKNRYTNILPTPATRVPLsqigPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEY
 | | .. .|.||||. . . .  . .  . |.   ||||..|||   .|| |    .|  | | ||..|||||....|||||||.|.||.||||||||.
lekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

RSEVVVMMTGIREGGRIKCHRYWPEHTEA-PLDTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRART
...|.||.| . | ||.||..|||.  .  .|   .|.. . |.|. ..|....|.|..  .| .| | ||..|.|||||||. . ........||.|. 
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale

D--RALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPhRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
   .  | |||||||.||||||.|.|. .. |.   . |||.  . .||.|| |..||. ||.|...|. .|.
alpsngpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 82-351 6.4e-46 151.4 In-house 8-294 (301) alignment 
Range on Protein: 82-351
Range on HMM: 8-294/301.0
HEALRDREMLEEEFERAPHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGP--DALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWE
|.|    . .||....  ..   . |.  . . .. ||. || . .  |. |..      .  .|.||...|||.. |.|||.|||  .|. ||||..|.
hvaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwq

YRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQNFQISIASTENMKHYILTKLTLE---------------HRASGATRAVSHFWFTNWPDHGV---P
..   .||.|. .|| . ||..|||. ..   .  .|.. . .. ..  ... .|..                 ... ... |  .  |.||..||   |
ekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrep

HETWEVIDlvKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
.   .|||  . . | .     | |||||....|.|.. .|..|.        |||||.    .| .. | ..|  || ....... |..
rtvLqvid..dvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQcka.egVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 82-348 1.2e-45 150.6 In-house 13-234 (392) alignment 
Range on Protein: 82-348
Range on HMM: 13-234/392.0
HEALRDREMLEEEFERAPHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYR
 |  |   .. |||   |   . |.|  . .    |||| ||||  ..|| |  |   . | |.|| ....... | .||.|||.. ..|||||||.. .
veknrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqen

SEVVVMMTGIREGGrikchrywpehteapldtqnfqisiastenmkhyiltkltlehrASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDR
   ..|.| ..||                                                 .|.|. | ||.|||..||. |  .. ..| |.    . 
vttiamvtklkegd............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqy

ALPAVVHCSAGIGRTGTFLAVDMGIRSlNNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKD
. | ..|||||.||||  ...|  .    .  |.||||  . ..| .|   .||  || |.. |. .
thpliihcsagvgrtgvvisidsvvah.akktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
0051299 (Phosphotyrosine protein) phosphatases II 85-350 4.9e-90 297.1 In-house 19-286 (288) alignment 
Range on Protein: 85-350
Range on HMM: 19-286/288.0
LRDREMLEEEFERAPHMLVGPD-TLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSE
...  .|.||||. ...|. .. .  . |    ||||..|||   .|| || ....  |.| ||...||||....|||||||.|.||.||||||||....
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvr

VVVMMTGIREGGRIKCHRYWPEhtEAPLDTQNFQISIASTENMKHYILTKLTLEHR----ASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRART
|.||.|.. | ||.||..|||.  . .|   .... . |.| ...|....|....      .| .| | ||..|||||||||. . ...|....||.|. 
vIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala

DRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPhRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
..  | |||||||.||||||.|.|. .. |..  ..|||.. . .||.|| |..||. ||.||..|. .|.
sgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 85-351 1.4e-85 282.6 In-house 14-277 (317) alignment 
Range on Protein: 85-351
Range on HMM: 14-277/317.0
LRDREMLEEEFERAPHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEV
..|  .|.||||. ... . . .  . |    ||||..||| ...|| || .|.|  |.| ||..|||.|....|||||||.|.||.||||||||....|
ksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

VVMMTGIREGGRIKCHRYWPEhtEAPLDTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALP
.||.|   | ||.||..|||.  . .|   .|.. . |.| .....|..|..|.  .. .| | ||..|.|||||||  . ...|...|||.|. |.  |
ivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggp

AVVHCSAGIGRTGTFLAVDMGIRSLNNPHrVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
 .||||||.||||||.|... .. |.  .  |||.  . .|| ||.|..||. || |...|. .|..
vlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylk
0043336 (Phosphotyrosine protein) phosphatases II 85-350 4.5e-83 274.2 In-house 16-277 (278) alignment 
Range on Protein: 85-350
Range on HMM: 16-277/278.0
LRDREMLEEEFERAPHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEV
| .. .|..|||. ... ... .  . |    ||||..||| . .|| || .| |  |.| ||..|||||.|..||||||| ||||.||||||||.....
lnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

VVMMTGIREGGRIKCHRYWPehtEAPLDTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALP
.||.|.  | ||.||..|||   . .|   .|..   ..| ...|....|..... .| .| | |.....|||||||. .  ..|..||||.|. |.  |
ivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngp

AVVHCSAGIGRTGTFLAVDMGIRSLNNPHrVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
 .||||||.||||||.|... .. |.. .  ||..  . .||.||.|..||. || |...|...|.
vlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 85-347 1.6e-73 242.3 In-house 17-276 (288) alignment 
Range on Protein: 85-347
Range on HMM: 17-276/288.0
LRDREMLEEEFERAPHML-VGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSE
 |.|. ..||..  . .     .|  . .. | |||| ||||   .|| | .    | . |.||...||... |..|||||| ..||.|||..|.|....
arnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

VVVMMTGIREGGRIKCHRYWPEHtEAPLDTQNFQISIASTENMKHYILTKLTLEhrASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRAL
 .||.|.. |||. ||..|||.  . |    .... . .........| || ||   ..  . . .. .. |||||||. . ....|.. |  | .. . 
tivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtg

PAVVHCSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMK
| .||||||.||||||.|.|. |  ... . ..||.| . ||| ||   .||  || |..... 
piivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 85-348 3.6e-64 212.1 In-house 30-289 (319) alignment 
Range on Protein: 85-348
Range on HMM: 30-289/319.0
LRDREMLEEEFERAPHMLVG--PDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRS
  |.  || || ||... |     |  | ..   |||..|||.   ..| | ..     | |.|| ||.|| ... .||.|||...|..|||||.|||..
dddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweync

EVVVMMTgireggRIKCHRYWPEHTEapLDTQNFQISIASTENMKHYILTKLTLEHRA-SGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRA--RT
  .|..|      . || .||| ...     ..|.... | |. . |.. .. | . .     | .  | |  |||.|||. . ... ||| ||    . 
stivllt......kdkcsqywplkiv..ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltske

DRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKD
.   . |||||||.||||.....|. .  ...  . |||.  .  || ||   .| .||| |.. |. .
nhranivvhcsaGvGrtGvyivldvlldrmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPRA_pd Subfamily PTPRA 86-353 1.9e-72 238.9 In-house 29-298 (330) alignment 
Range on Protein: 86-353
Range on HMM: 29-298/330.0
RDREMLEEEFERAPH-MLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEV
 | ... |||.  |   . .   | .      |||. ||||   .|| ||..     | |.|| |.|||.. ..|||.|||| |||.|||||.||..|  
ddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksat

VVMMTGIREGGRIKCHRYWPEhtEAPLDTQNFQISIASTENMKHYILTKLTLEHR----ASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTD
.||.| ..|  . ||..|||.  |  .   | ....  .. ...| . |. ...        ..| |. | || ||| ||| |.  ...|.|.|.. .  
ivmltelkerkeekcaqywPd..eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqq

RALPAVVHCSAGIGRTGTFLAVDMGIRSLNnPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVTPG
 | | |||||||.||||||...|  .  ..   |.||||. . .||.||   .||  || |.......|   |
sagpivvhcsaGvGrtGtfivldavlervk.aerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylyg
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 86-351 1.2e-62 206.6 In-house 15-277 (515) alignment 
Range on Protein: 86-351
Range on HMM: 15-277/515.0
RDREMLEEEFERAPHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVV
|   .. |||   |   . |.|. ..     |||| ||||   .|| |  |  .  | |.|| .. ...  | .||.|||.. .||||||.|....   .
rhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvtti

VMMTGIREGGRIKCHRYWPEHTEAPLDTQNFQISIASTENMKHYILTKLTLEHRASgaTRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPA
.|.|  .|| .||| .|||..    .   ...... |.|     |  |||. .     .|.|  | ||.|||.|||..|  .. |.|.|.  .   . | 
amvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpl

VVHCSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
..|||||.|||| ....|  .   ..  |.||||  . ..| .|   .||  || |...|..... 
iihcsaGvGrtGvvisidsvvahakt.trmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 86-351 1.6e-61 202.9 In-house 16-278 (315) alignment 
Range on Protein: 86-351
Range on HMM: 16-278/315.0
RDREMLEEEFERAPHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVV
|   .. |||   |   . . .   ..    |||| ||||   .|| |  |  .  | |.|| .. .... | .||.|||.. .||||||||....   .
rhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvtti

VMMTGIREGGRIKCHRYWPEHTEAPLDTQNFQISIASTENMKHYILTKLtlEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPA
||.|  .|| .||| .|||..     .  ...... |.|     .  ||    | | ..| |. | ||.|||.||...|  .. |.|.|.  .  .  . 
vmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsl

VVHCSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
.||||||.|||| ....|  .  ...  |.||||  . .||..|   .||  .| |...|..... 
lvhcsaGvGrtGvvisidevvaqikr.trsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 87-355 8.4e-56 184.4 In-house 21-293 (325) alignment 
Range on Protein: 87-355
Range on HMM: 21-293/325.0
DREMLEEEFERAPHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVvV
|.. .  ||.  |       .    |    |||. |...   .|| |   . |. | |.||...  . . . |.|.| |...|..|.||.| ..|. | |
dqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsv.v

MMTGIREGGRIKCHRYWPEHTEAPLDTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEV---IDLVKAVR---RARTD
... . ..|  .|  |||..         ..... . |..  |.  .| .     | ||.|  | .  |.| ||..    .   ..|||||    .| | 
vvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantk

RALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHRvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVTPGNS
 . | .||||||.||||.|...   .  . .  | ||.|| . ||| .|   ..|  || ....|. ...  ||.
astpilvhcsaGvGrtGvfislysalakvieesr.vdifgfvkklrkdrpsmvetvdqyiliyealveaymsgnt
subfamily_CG42327_pd Subfamily CG42327 87-277 1.4e-37 124.1 In-house 3-193 (319) alignment 
Range on Protein: 87-277
Range on HMM: 3-193/319.0
DREMLEEEFERAPHMLVGPDTLPndPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQ-PKEFIATQGPKPETVDDFWRMVWEYRSEVV
 || . |||.  | ..   | .|  .    |.|. |..| | ||| | .|| |  . |..|..| ||.. |  .||.| .  ..  ||||.||| .| |.
rredvaeefrdlPqliaradevP..vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvi

VMMTGIREGGRIKCHRYWPEHTEAPLDT--QNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFtNWPDHGVPHETWEVIDLVKAVRRA
| .| . | |  .| .|.| .   .      ......   |  ..|... | | .     .| ..|.|. .|.. .|| |   .| ..  || .
vqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 87-164 6.7e-09 29.8 In-house 22-95 (95) alignment 
Range on Protein: 87-164
Range on HMM: 22-95/95.0
DREmLEEEFERAPHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQigpDALSTYMNANFVDGYNQPKEFIATQG
|.| ...||   .     | |         |||. ||.|  |||| |.       | |.|| ||||| . . .||.||
dqe.fdnefksismtsgapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 88-355 1.2e-72 239.7 In-house 21-288 (305) alignment 
Range on Protein: 88-355
Range on HMM: 21-288/305.0
REMLEEEFERAPHMlVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVM
 . ||....  ..    .  . ..   . |||...| . .  |. |..   .  | |.||..||||.. |..|..||| ..||.||||...|.. ...||
dkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivm

MTGIREGGRIKCHRYWPEHTEAPLDTQNFQISIASTENMKHYILTKLTLEH-RASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRART-DRALPA
.|...|||. ||..|||| .  . . ..|.. . |..... ||  ||..   . .  .|.|... .|.|||||||...  ...|.| |....  |.  | 
ltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpl

VVHCSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVTPGNS
.||||||.||||.|.|||. .  |..   |||||. . .||..| . .||  || |.|.|.....| |. 
lVhCsagvgRtGvfiavdialerlkk.EevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdt
subfamily_PTPN6_pd Subfamily PTPN6 89-351 1.8e-67 222.5 In-house 26-298 (306) alignment 
Range on Protein: 89-351
Range on HMM: 26-298/306.0
EMLEEEFERAP---HMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSqiGPDA-LSTYMNANFVDG--YNQPKEFIATQGPKPETVDDFWRMVWEYRS
. .|||||.     .. .   .  . |. . |||| ||||   ||| |.   |.   |.|.|||....   .. |..|||||  ..|| |||||||.  |
agfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqens

EVVVMMTGIREGGRIKCHRYWPEHTEAPLdTQNFQISIASTENMKHYILTKLTLEH-RASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDR
.|.||.|   | |. || ||||...| .  . . ...  | .....||| .|.... . .. .| | .. |..|||||||...  |.|... |.| . . 
rvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeel

A----LPAVVHCSAGIGRTGTFLAVDMGIRSLNNP--HRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
.     | ||||||||||||||. .|. .. ...   .  .|.   . ..|.|| | .||  || ||..|.| |. 
eeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
subfamily_Ptp69D_pd Subfamily Ptp69D 89-354 2.3e-64 212.4 In-house 22-290 (307) alignment 
Range on Protein: 89-354
Range on HMM: 22-290/307.0
EMLEEEFERAPHMLVGPDTL-PNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVM
. |..|.|. ..  .  .|   .    |.|||| .| .   ||| |..|  .. |.|.||.|. ||.. |.||| |.|  .|..|||||..|  ....||
fglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivm

MTGIREGGRIKCHRYWPEHTEAPLDtqNFQISIASTENMKHYILTKLTLEHRA-----SGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRA
.. . |  | ||..|||. .|   .  .  . ..|.|....||  .| . .         ..| |  . .|.|.|  ||. .  ...|.. ||       
lsnlteknrkkcakYWpiedevqyg..dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnr

LPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHRvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVTPGN
 | ||||||| ||.|.|.|.|. .  |.. .. ||.|  . .|| ||   .| . || |...|. || . |.
sPivvhCsaGvgrsgifvaldsllqqlkaedk.vdifetvkdLrsqRnllvqsleqYvflyralldyssygd
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 89-353 3.6e-48 159.1 In-house 20-282 (439) alignment 
Range on Protein: 89-353
Range on HMM: 20-282/439.0
EMLEEEFERAPHmlVGPD-----TLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSE
|...|.||      . ||     .|  .     |||| .. .   ||| | .|     | |.|||...|| ..| .||||||| ||.|||||.|.| .. 
eifkeifekins..tspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktv

VVVMMTGIREGGRikchrYWPEHTEAPLdtQNFQISIASTENMKHYILTKLT--LEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDR
 .||.| . |  .     |||  .|.     .  . .    .. .|..  .    |.  .   |.| .| .. |||. || ..  |.|...|.  |  ..
tivmltnlvesyk.....ywpsdaevcy..gdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandke

-ALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHRvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVTPG
   | |||||||.||||| .|.|. .  |.   . ||. | .  || ||   .|...||.|...|. . .  |
eygpvvvhcsagvGrtGtiialdialeqlklenk.vdikgivkvlrkqrkqmvqalcqyvfiynavledivyG
subfamily_PTPRD_pd Subfamily PTPRD 90-354 3.1e-96 318.2 In-house 24-285 (564) alignment 
Range on Protein: 90-354
Range on HMM: 24-285/564.0
MLEEEFERAPHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMT
 .|||...  .    . .  | |   .|||| ||..  ..|| ||..  |  | |.||.|.|||...|..||||||..||..||||||||..|...||.|
kfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmlt

GIREGGRIKCHRYWPEHtEaPLDTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHC
 ..| |. |||.||||. . .   ....... ..|....|......|..  |  .| | .| ||.|||||||... ...||.. ||..... | | ||||
kleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhC

SAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVTPGN
|||.||||||...|. .. ...  ..||... ...||.||   .||  || |.|.|. .... ||
SaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgn
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 90-354 2.6e-79 261.6 In-house 24-287 (319) alignment 
Range on Protein: 90-354
Range on HMM: 24-287/319.0
MLEEEFERAPHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMT
.||.||.   .      .  . ..   ||||.|||.   ||| ||..     |.|.||.|.|||.. ..|||||.|. .|..||||||||..| .|||.|
llekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmlt

GIREGGRIKCHRYWPEHTeaPLDTQNFQISIASTENMKHYILTKLTLEHRASGA-TRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTD-RALPAVV
.. | ...|...||||..  . .  .. . . . |....||  ||.|....|   || |.|| .|.||||.||...  ..||.| .|..|    . | ||
klveklkvklkkywpeen..feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivv

HCSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVTPGN
|||||.||||||...|. .  ...   |.|||  . .|||||   .|.  || |...|. ..|. |.
hCsaGvGRtGtfivldamlervke.egvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 90-350 4.9e-78 257.0 In-house 6-268 (274) alignment 
Range on Protein: 90-350
Range on HMM: 6-268/274.0
MLEEEFERAPHMLvgPDTLPNDPRVAMKNRYTNILPTPATRVPL-SQIGPDALSTYMNANFVDGYN-QPKEFIATQGPKPETVDDFWRMVWEYRSEVVVM
 ||.||   |     .   .. .. . ||||..||| . .|| | |. . | .|.|.|||.. ||. . | ..||||| |.||.|||||... ...|.||
dlekeflelPlnf..dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivm

MTGIREGGRIKCHRYWPEHTEAPLDT--QNFQISIASTENMKHYILTKLTLEHRASgaTRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALP-
.| ..|  . ||..|.|..... ..   ....| . .. . ..| ..||.|..  .  .| | |.|.|.|||| .|... ...|||. |...|.... . 
ltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenakl

--AVVHCSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
  .|||||||||||| |.|.....| |.. . ||||.. . .|| .||| .||  || ..|.|.  |.
apvvvhCsaGiGrtGcfiaisiavrqlre.eivvdvlkivcnlrldrGGmvqtseqyelihralclyl
0046845 (Phosphotyrosine protein) phosphatases II 91-351 9.5e-88 289.5 In-house 2-275 (284) alignment 
Range on Protein: 91-351
Range on HMM: 2-275/284.0
LEEEFERAPHMLVG---PDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPD-ALSTYMNANFVDGY-----NQPKEFIATQGPKPETVDDFWRMVWEYR
||||||. ... |    . .  . |    ||||..|||   .|| |. ...|   |.| ||..||||     ...|.|||||||.|.||.||||||||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SEVVVMMTGIREGGRIKCHRYWPEHtEAPLDTQNFQISIASTENMKHYILTKLTLEHRA-SGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRART-
..|.||.|.. | ||.||..|||.  . .|   .|.. . |.|....|....|.|..   .| .| | ||..|.|||||||...  .......||.... 
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-DRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHR--VVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
 ..  | |||||||.||||||.|.|. .. |.. ..  .|||.. . .||.|| |..||. ||.||..|. .|. 
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 91-354 1.9e-82 271.8 In-house 22-284 (318) alignment 
Range on Protein: 91-354
Range on HMM: 22-284/318.0
LEEEFERA-PHMLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMT
|.||.||  ..      .  ..|  ..||||.|||.   ||| |...  .  | |.|||..|||.. |..||.|.| |||..||||||||  | |.||.|
lseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmlt

GIREGGRIKCHRYWPEHTeaPLDTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRAR-TDRALPAVVH
 ..| |..|.|||||..   .   .. .. . .. ....|.| ....... . ..| |  . .|.|||.|||... ...|||. |..|  .  | | |||
qeeergkakvhryWPskg..srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvh

CSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVTPGN
||||.||||.|.|||. .. ...   .||||. . .||.||   .||  || |.......... |.
CsaGvGrtGvfiavdillerika.ealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd
subfamily_PTPN13_pd Subfamily PTPN13 92-346 2.4e-72 238.5 In-house 14-265 (273) alignment 
Range on Protein: 92-346
Range on HMM: 14-265/273.0
EEEFERAPHMLVGPDTLPNDP-RVAMKNRYTNILPTPATRVPLSQIGPdalstYMNANFVDGY--NQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMM
.|||.   ..    ..      .   |||| |.||  .|||.|.. |.     |.||...     ..  |.||.||| ||||.|||.|||| ..||..|.
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TGIREGGRIKCHRYWPEHTEAPLDTQN-FQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDrALPAVV
|  .|.|..||||||||... .|  .| ....   ..... . . .|.... .||..| |.|. |..||||||| .. |.. .|. ||| .|| |.| ||
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtd.agPivv

HCSAGIGRTGTFLAVDMGIRSLNNPHrVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAM
||||||||.||....|. .  ... .  .||   . ||| || | .||  ||.||..|.
hcsaGiGrsGtlitidvvlglierdk.efdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_PTPRB_pd Subfamily PTPRB 93-351 2e-85 281.4 In-house 29-286 (293) alignment 
Range on Protein: 93-351
Range on HMM: 29-286/293.0
EEFERAPHMLVG-PDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGI
||.|.  ..      .  . .. . |||||||||  ..|| |...  .. | |.|||...|||.|.|||||||| ||||||||||||| .|...||.| .
eeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltql

REGGRIKCHRYWPEHTEaPLDTQNFQISIASTENMKHYILTKLTLEHraSGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRAR--TDRALPAVVHC
 |.|..||..|||...| |    . .... ..|....... .|..|.  . ..| | .. || |||||||..|. ..|.|..||.|   | .. | ||||
vekgkvkCeeYWPadee.pvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhC

SAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
|||.||||||.|.|. ...... . .||.|| ...||..|   .||  ||.|.||.. |...
saGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 101-350 5.4e-79 260.0 In-house 7-264 (270) alignment 
Range on Protein: 101-350
Range on HMM: 7-264/270.0
MLVGPDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYN-QPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKC
  . ...||.  | .  |||..|||.||||| |...  |  ..|.|||.| |.. ..|..||..||.| |. .||||.|| ... .||.||. | || ||
eetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkC

HRYWPEHTEAPLDTQNFQISIASTE--NMKHYILTKLTLEhrASGATRAVSHFWFTNWPDHGVPHETW------EVIDLVKAVRRART--DRALPAVVHC
 ||||....  ..... .|......  ... ||||.|.||   .| .| . |||...|||||||.|.       ... ...|||| ..  |.| | .|||
erYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHc

SAGIGRTGTFLAVDMGIRSLNNPHRvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
|||.|||||..|.|...| |.. .. |||   . .|| .|   .|. .|| |...|.  |.
saGvgRtGtlialDiavrlLeetkk.vdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_PTPRK_pd Subfamily PTPRK 104-348 3.8e-68 224.6 In-house 34-275 (314) alignment 
Range on Protein: 104-348
Range on HMM: 34-275/314.0
GPDTLPNDPRvAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYW
| |.  .| .  .|||...||.   .|| | .|  |. | |.||...|.|..|..||.||||..||| ||||.|.....  .||.| . | ||.|| .||
gwdaakkden.reknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyW

PEHTEApldTQNFQISIASTENMKHYILTKLTLEH--RASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLA
||.||     ..... . .||  . ..   ...|.  |.  ..| | .| |..||||.||..   ...||. |   . ..| . ||||||| ||||||.|
Pedtev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfia

VDMGIRsLNNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKD
.|. .  . . ..|||||  . .||...   ..|  || |..... .
idivld.mieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 105-350 2.3e-59 195.9 In-house 40-280 (315) alignment 
Range on Protein: 105-350
Range on HMM: 40-280/315.0
PDTLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWP
|    ..     |||| ||...  .|| |  .  |  | |.||||.||||... .||.|||....|.||||.|.|.    .||.|.. || . |. .|||
pldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp

EHteaPLDTQNFQISIASTENMKHYILTklTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDM
..    .   .. ..  | |  ..|     ||        | |  . .| ||| |||. |  ...|.. |.. .|. . . |||||||.||||||...| 
dk...kviyGkitvtrkseevnteytvr..tlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitlda

GIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKD-YV
 .  ..   ...||.  . ..| .| . .|.  || |...|. . .|
vldqaea.enaidvynfitgvrqnrikmvqvaeqyqfiydalletfv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 107-348 2.8e-62 205.8 In-house 18-253 (284) alignment 
Range on Protein: 107-348
Range on HMM: 18-253/284.0
TLPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTgireggRIKCHRYWPEH
|  | ..   |||...||.   ..| | ..     | |.|| |. || ... .||||||...|..|||||.|||..  .|..|      . || .||| .
tfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplk

TEapLDTQNFQISIASTENMKHYILTKLTLEHRA-SGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRA--RTDRALPAVVHCSAGIGRTGTFLAVD
..     ..|.... | |. . |.. .. | . .     | .  | |  |||.|||. . ... ||| ||    . .   . |||||||.||||.....|
iv..ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld

MGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKD
. .  ...  . |||.  . .|| ||   .| .||| |.. |. .
vlldrmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPRG_pd Subfamily PTPRG 108-354 1.2e-71 236.6 In-house 41-291 (563) alignment 
Range on Protein: 108-354
Range on HMM: 41-291/563.0
LPNDPRVAMKNRYTNILPTPATRVPLSQIGP-DALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEh
  ..|    ||||.||..   .|| ||..   .    |.|||..|||.. |.||||||| ..|.||||||.|| .....||.| . | || ||..|||. 
hsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.

tEAPLDTQNFQISIASTENMKHYILTKLTLEHRA---S---GATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFL
 . ... ...|. . ..| .  |   .|.....           . | .. .|.|||||||. .  |.  ||   .|. . | | |||||||.|||||..
.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyi

AVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVTPGN
..|  .. ... . .|.||| . ..|.||   .||  ||.|.|.|. . .. ..
vldtllkqiqq.enavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 108-349 1.1e-43 144.0 In-house 31-268 (281) alignment 
Range on Protein: 108-349
Range on HMM: 31-268/281.0
LPNDPRVAMKNRYTNILPTPATRVPLSQIGPDALST-YMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEH
  |.|    ||||.||     .|| |    |.  || |. ||..      . .| ||||| ||  |||||.|.  .  .||.  . |  | ||  |.|  
vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn

TEAPLDTQNFQISIASTENMKHYILTKLTLEHraSGATRAVSHFWFTNWPDHGVPHETwEVidLVKAVRRARTdRALPAVVHCSAGIGRTGTFLAVDMGI
. . |. ... .|   .   |  . |.| | .   | || ..|. . .|||  ||. . ||  ..| .|. |. |. | |.|||||.||.||..||.. .
ahcclqfdklsvsyedstvnkslvttrlnlsy..egetrlithwlwkewpdwqvpess.ev..mlkilrkira.rstppvihcsagvgrsgtlmaveial

RSLNNPHRVVDVFGDMIKLR-TQRGGSIQTFVQYLFVHQAMKDY
.|. .   . |.   . .|| | |  |.||. ||... . . |.
qsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_PTPN3_pd Subfamily PTPN3 110-346 2.2e-63 208.8 In-house 37-271 (280) alignment 
Range on Protein: 110-346
Range on HMM: 37-271/280.0
NDPRVAMKNRYTNILPTPATRVPLSQigpdALSTYMNANFVD----GYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPE
. |. . |||| .|||  |||| |..    . . |.|||.|.    . .. . .|||||| ..|. |||.|||| .|...||.| . | ||.|||.||||
rkpenlsknryrdilpydatrvklke....setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe

HTEApLDTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMG
...  |.  .|.. . .... | |.| .|.|.....   | . .. ...|||||||... .....|. ||..|. .  | |||||||||||| ...... 
tede.leygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilleta

IRsLNNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAM
.  | . .. | .   . ..| ||.  .||  || || .|.
la.lieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 110-350 2.1e-53 176.0 In-house 38-277 (287) alignment 
Range on Protein: 110-350
Range on HMM: 38-277/287.0
NdprvAMKNRYTNILPTPATRVPLSQIgPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHtEA
.    . ||||...||   ||| ||.  ..  | |.|||.| .|.. ..|||.||| . || ||||.|.| || .|..||   | .| ||..||||. | 
a....vkknryadvlPiddtrvllsae.gelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.ev

PLDTQNFQISIASTENMK-HYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAV----RRAR-TDRALPAVVHCSAGIGRTGTFLAVD
|.    . . . . .... .|    | | .  .  .| |  . . .|||....  .  .| .|  |      || .. . | |||...||||.|..||. 
PmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatl

MGIRSLNNPHRvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
. .. |..  | |||   .|.|| .| . .|. ||. .. .|.  | 
vlvsrledlGr.vdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_PTPN12_pd Subfamily PTPN12 111-351 1.8e-74 245.2 In-house 37-278 (290) alignment 
Range on Protein: 111-351
Range on HMM: 37-278/290.0
DPRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAP
 ..   |||| .|||   .|| ||.|  .  | |.||||. | ....|.||.||| |.|.||||||.||.. |.|||.  . | |..||.|||||..| .
keenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeee

LDTQNFQISIASTENMK-HYILTKLTLEHRasGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSL
| ...|...  . ....  ...  |..|..  ...| |  | .|.|||||||. . ....|...||. ... . | |||||||.||||| .|.|.  . |
lefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrell

NNPHR--VVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
.. .    .|||  ...||.||   .||  || .|..|. ..|.
kaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
0049772 (Phosphotyrosine protein) phosphatases II 111-352 4.2e-43 143.6 In-house 43-282 (314) alignment 
Range on Protein: 111-352
Range on HMM: 43-282/314.0
DPRVAMKNRYTNILPTPaTRVPLSQIGPDAlSTYMNANFVDGYnqpKEFIATQGPKPETVDDF----------WRMV--WEYRSEVVVM-----------
....  ||||..||| . .|| |.  . .  | | ||..|||.   . |||||||...||.||          ||||  ..... ..||           
lflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------MTGIREGGRIKCHRYWPEHTeapldtqnfqisiastenmkhyiltklTLEHRASGATRAVSHFWFTNWPDHGVPhETWEVIDLVKAVRRA
           ... ..| . . ......                            .  . ..  .|.. ... ...||...|  .  . ........|
rLdaAlgKtpllildgngneptaadlellk...........................eelydpelferlgikylripvpDgsap.lledfdeflefieea

rtDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNnphrvVDVFGDMIKLRTQRG-----GSIQTFVQYLFVHQAMKDYVTP
  |.  | .|||.||.||||||..... .. |.     |..   .  .| .|      |.|... ||.|...|...|.  
..dkggpvlvHCkaGkgRtgtfvvaaylmkllg.....vsleealedvrlkRpinpnpgfieqleqyefilealleylkf
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 111-260 6.1e-17 56.0 In-house 93-235 (244) alignment 
Range on Protein: 111-260
Range on HMM: 93-235/244.0
DPRVAMKNRYTNILPTPATRVPLSQIgpDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGgrikcHRYWPEHTeaP
.|  . |||    ||    |||||.       ||.|| ||    .  |.| || |  .|  |||.|. |   .|.|..  . |        |||.    |
npnnswknregaglpfdfnrvplskg..smgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdse..p

LDTQ--NFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGV
|.    .  ....  ...|    ..| .|     . .|.. |  .|||  | 
lewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgt
DSPc_SM00195 112-350 5.3e-80 263.9 In-house 24-262 (263) alignment 
Range on Protein: 112-350
Range on HMM: 24-262/263.0
PRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPL
..   ||||.||||   ||| |...  .  |.| |||...|.|..|..||||||.|.||.|||||||| .....||.|   | |..||.|||||  . . 
kknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggke

DTQNFQISIASTENMK-HYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLN
. ..... . ..|..| ..||..|.|.. .   || | .....||||||||..| .|..|..||.  .     | |||||||.||||||...|. ...|.
tfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskle

NPHRvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
. .. ||.|  . .||.|| |..||. ||||...|. .|.
eekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 112-350 5.3e-80 263.9 In-house 24-262 (263) alignment 
Range on Protein: 112-350
Range on HMM: 24-262/263.0
PRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPL
..   ||||.||||   ||| |...  .  |.| |||...|.|..|..||||||.|.||.|||||||| .....||.|   | |..||.|||||  . . 
kknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggke

DTQNFQISIASTENMK-HYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLN
. ..... . ..|..| ..||..|.|.. .   || | .....||||||||..| .|..|..||.  .     | |||||||.||||||...|. ...|.
tfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskle

NPHRvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
. .. ||.|  . .||.|| |..||. ||||...|. .|.
eekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN9_pd Subfamily PTPN9 112-350 9e-74 243.2 In-house 40-290 (297) alignment 
Range on Protein: 112-350
Range on HMM: 40-290/297.0
PRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPL
.    |||||..|    ||| |...  |  | |.||||||||.|.| ||||||| ..||.|||||||| .  |.||.| . | ||.|| .|||...|.  
ranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessa

DTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTD-------------RALPAVVHCSAGIGRTGT
.  ....|  ..|....|  ..|....   . .| |.|| |. |||.|||... ...|....||....              .  | |||||||||||||
efgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGt

FLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
| ..|. .  |..   .|||.  . .|||||  ||||  || | ..|. .| 
fitldiclsrlee.vgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 112-351 1.3e-65 216.1 In-house 7-243 (250) alignment 
Range on Protein: 112-351
Range on HMM: 7-243/250.0
PRVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIkCHRYWP-EHTEap
|.   ||||..|..   .|| | .   |  | |.|| |..||.. | ||||||| ..|. ||||||.|. |...||.| ..| ..  .|.||| |..|  
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae..

lDTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTD-RALPAVVHCSAGIGRTGTFLAVDMGIRSL
    . ..|. |.|..  |. .|| | ..     | | .. |..||| |||...  |..|.| |.. .    . | .|.||||.||.|.|.|.|  .  |
.kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerl

NNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
..  .|||||  ...||..| .....  || ||..... ...
kk.ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_PTPN1_pd Subfamily PTPN1 112-346 1.1e-55 183.4 In-house 30-267 (290) alignment 
Range on Protein: 112-346
Range on HMM: 30-267/290.0
PRVAMKNRYTNILPTPATRVPLSQIGPdalsTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTE---
|.   .||| .. |   .|. | .        |.||..|.  .  ...| |||| |.||| ||.|||| .|  |||.  . | ..|||..|||.. |   
penrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeeke

APLDTQNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRAR--TDRALPAVVHCSAGIGRTGTFLAVDMGI
  |.  .... . |.|. ..|.. .| || . .  || ..|| .| ||| |||.     ....  ||..   ..   |||.||||||||.|||  ||  .
llledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtcl

RSLNNPHR--VVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAM
  ... .    ||.   ...|| .| | |||  |  | ..|.
vliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 113-350 5.9e-77 253.5 In-house 40-276 (281) alignment 
Range on Protein: 113-350
Range on HMM: 40-276/281.0
RVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTeAPLD
   .||||.||    |||| ...   .  . |.|||||.||...||.|||||| |.....||.||||.. ...||.|   |.|..|||||||... . | 
envlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddn.selk

TQNFQISIASTENMKHYILTKLTLeHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRA-LPAVVHCSAGIGRTGTFLAVDMGIRSLNN
  .....  ..|. ..||  |..| .| || || |... .|.|||||||..| |...  |.|..... .   | |.|||||.|||||..|.|  ......
ygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkavea

PHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
 .. .||   . .|| .|   .|| ||| ||..|..|..
eleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 113-354 1.1e-72 239.8 In-house 55-294 (298) alignment 
Range on Protein: 113-354
Range on HMM: 55-294/298.0
RVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLD
.   ||||..|..   .|| |...  |  |.|.|| |...|.. . |||||.| .||| ||||||.|. ....||.| ..| ...|.|.|||.. ..  .
enkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketyg

tqNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRA-LPAVVHCSAGIGRTGTFLAVDMGIRSLNN
  ....|. |.|..  .| .||..... .  .| | .. ||.|||.|||...  |.||.. ||. ...    | .|.||||.||.||| |.|  .  ...
..eitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkk

pHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVTPGN
  .|||||  .. ||..| |..||  || |...|. .... .|
.eqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn
subfamily_ptpA1_pd Subfamily ptpA1 113-310 5.8e-44 145.5 In-house 46-257 (418) alignment 
Range on Protein: 113-310
Range on HMM: 46-257/418.0
RVAMKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGyNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPL-
. . |||||||||   ||| | .|     | |.|||..||   ||.||.|||| |.|. |||||||| |  ..||..   |  |||| |||||.      
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf

---DTQNFQI---SIASTENMK---HYILTKlTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRA------RTDRALPAVVHCSAGIGRT
      |  .   |.   | ..   . |.|.  .     | || .... .  |||| .|  |  . .|....          .|| .| .||||||.|||
siygngnevfgtysvelveviqdpereiitr.nirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrt

GTFLAVDMGIRSLN
||| .  . .. |.
gtfctavimmkkld
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 114-350 1.1e-31 104.9 In-house 33-259 (267) alignment 
Range on Protein: 114-350
Range on HMM: 33-259/267.0
VAMKNRYTNILPTPATRVPLSQIGPDalstYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGgRIkcHRYWPEHTEAPLDT
.. .||. . ||   |||.|..   .    |.|| .|.||.. . ||.||.|   |. ||. .. ...  |.|..| . ..  |  ...|| .       
nqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd.ni..rlfwPPkmgqakky

QNFQISIASTENMKHYILTKLTLEHRASGAtRAVSHFWFTNWPDHGVPHETWEVIDLVKAvRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNpH
|.. .  .  .. . | .  | |. .   | . |. ... .|      .   . .  . | .    .   | ||.||.|.||.|||| .|  .. . .  
qdltvehslekeendyqiitlelkfknesa.hnvtlyyykkwnintnnkpylkplfgila.knqlengnrPlvvacsdGvGrsGtflvidsqlerakt.e

RVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
 |.|.|  . |.| || | ..|  .|...|. . .| 
gvsdifdflrkirsqriglvdtkeryiyihellaeya
0045098 (Phosphotyrosine protein) phosphatases II 115-350 1.9e-74 245.8 In-house 34-272 (278) alignment 
Range on Protein: 115-350
Range on HMM: 34-272/278.0
AMKNRYTNILPTPATRVPlsqigpdalsTYMNANFVDGYnqPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEhtEAPLDTQ
. ||||..||| . .||            | ||...|||  ||.|||||||.|.||.|||||.||....|.||.|.  |.||.||..||||  . .|   
ldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggsltyg

NFQISIASTENMKHYILTKLTLEHR----ASGATRAVSHFWFTNWPDHGVPHET--WEVIDLVKAVRRART-------------DRALPAVVHCSAGIGR
.|.. . |.|....|.|..|....     ... .| | |.....|||||||...  . ...|.. .|.|.              |.  | .||||||.||
dftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgR

TGTFLAVDMGIRSLnnpHRVVDVFGDMIKLRTQRGG-SIQTFVQYLFVHQAMKDYV
|||. |... .. |   ...||..    .||.||.| ..|.. || |..... ...
tGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 115-351 2e-59 195.9 In-house 47-284 (290) alignment 
Range on Protein: 115-351
Range on HMM: 47-284/290.0
AMKNRYTNILPTPATRVPLSQIG--PDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPld
  .||..||...   |..| .|.  .|    |.|| ...||.. |..|||||| ..|. |||...|. .. ..||.| | | |. ||. |||..  .   
kllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..

TQNFQISIASTENMKHYILTKLTLEHRAS-GATRAVSHFWFTNWPDHG-VPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLN
 ..|.| . . |....|| .|| .... | ||.. | .. .|||...| |....  .. . . ..  | .   . |||||...||...|.|....|   .
ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkck

NpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
    |.|||  . ..|.|. ||.|| .|| ...| .  |..
t.egvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_PTPN23_pd Subfamily PTPN23 115-348 2.4e-55 182.4 In-house 44-278 (288) alignment 
Range on Protein: 115-348
Range on HMM: 44-278/288.0
AMKNRYTNILPTPATRVPLSqigpDALSTYMNANFVDGYN-QPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDT
. |||...|||   .|| |     .    |.|| || .   .  .|||||.|...|. |||.||.| .|.|.||..   | |. |..|||||.....   
seknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkf

QNFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRR----ARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSL
....... |........  .|.||.. . |.. |||  .|.||..|||.   ........|.      .     | |||||||.||||.|  |   .| |
gdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrel

NNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKD
.. . ..|.   . .||.||  ..|.  |. |. .|.  
ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 115-346 1.3e-52 173.4 In-house 4-235 (237) alignment 
Range on Protein: 115-346
Range on HMM: 4-235/237.0
AMKNRYTNILPTPATRVPLSQIGPDalSTYMNANFVDGYN-QPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEhTEAPLDT
 .|||| ||     .|| |   | .  | |.||....|..  ||..||.|||   . ||||.|||. .  |.||.||. || ..|||.|||. |. |   
kiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywps.tdqpaay

QNFQISIASTENMKHYILTKLTLEHRAS-GATRAVSHFWFTNWPDHGVPHETWEVIDLVKAV-RRART-DRALPAVVHCSAGIGRTGTFLAVDMGIRSLN
  . .|.   |..  | .  |.| .| .    | .  . || |||.||| .|  .. . | .  |..   .. | ..|||||.|||| || .|  .|  .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

NpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAM
. ..|||..  .  .  .|   |||  ||.|.||..
e.kkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 115-348 9.6e-48 157.5 In-house 34-264 (283) alignment 
Range on Protein: 115-348
Range on HMM: 34-264/283.0
AMKNRYTNILPTPATRVPLSQIGPdalsTYMNANFVD---GYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEhtEAPL
  |||. .|.|.   || |    .    .|.|| |.     |.| |..|..|.|  .|| |||.||.. .   .||.| ..|. |||| .|||.  .   
krknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk..rGse

DTQNFQISIASTENMKHYILTKLTLEHRA-SGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLN
|  .| ...      . .|  .|.| . . . .|  ..|. . .| . |       .. . | .   .  .  | |||||.|||||..|.|.   .  . 
dyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdal

NpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKD
  . |||||  .  .| || . .||  || .||... .
t.esvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 115-349 7.4e-46 151.6 In-house 42-276 (307) alignment 
Range on Protein: 115-349
Range on HMM: 42-276/307.0
AMKNRYTNILPTPATRVPLSQIGpdALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTE--APLD
. ||||...     .|. .   |  . | |. ||..    .|| ||..|||. .|. .|| |. . . | |.|.  . | ..|||..|||          
tdknryqdvkcqdkgrivvkfdg..lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfg

TQNFQISIASTEN--M--KHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTdralPAVVHCSAGIGRTGTFLAVDMGIRS
 ..  ||.|      .   . ..   ||.   .. .|...|. ..||||.|||.     |.|..|||  .     | |||||||.||.|| .|. .    
eapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn....pvvvhcsaGvGrsGtivaislvqdk

LNNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDY
. .     |.   . .||.||  .||| .|||..|. . .|
miaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 115-351 2.2e-40 133.3 In-house 49-288 (305) alignment 
Range on Protein: 115-351
Range on HMM: 49-288/305.0
AMKNRYTNILPTPATRVPLSQIGPdalSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDT-
| |||| ..      || |    |     |. ||.|    .|| || || |  .|  ||| | .. . | . |.  . | |  ||. |.. . .  |.  
agknrykdvgcldnnrvklegpwp...heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefe

---QNFQISIASTENMKHYI-------LTKLTLEHrASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTdralPAVVHCSAGIGRTGTFLAVD
   |  .. . |....|           |.|..|  . . .| |.|. . .||| |||     ...|..  | ..     | ||||||||||||. . ..
ekgqkisvkfessvtlkfrkdakakvtetvlvieg.pgekarkvthyhwidwpdrgvpaadlailellekarpskg....pivvhcsagigrtgsvvmle

MGIRSLNNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
  .  | . . . |    . |.| ||  ||||  ||||||| . .|. 
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 115-343 4.7e-25 83.3 In-house 20-252 (290) alignment 
Range on Protein: 115-343
Range on HMM: 20-252/290.0
AMKNRYTNILpTPATRVPLSQIGPDALSTYMNANFVDgYNQPKEFIATQGPKPET-------VDDFWRMVWEYRSEVVVMMTGIREGGRI----KCHRYW
.|..|... |   ||||.| . |    . |. ||.|  . .  ..|.|| |. ..       . .|| |. . ... |||.    |  .      | .| 
emdqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYv

PEHTEAPLDTQNFQISIASTENMKHYILTKLTLEHRAsGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTdralPAVVHCSAGIGRTGTFLAVD
||. .  |  ......  | |. .  .  .|....   .    | | .. .| .  |...|  ...|.. |.  .|    |..|||  || |  .. |..
pesvgeelkfkgltvkCkskekeddvetRelvvkfdd.eeeftvtHsllkgWnklnvqedtktllsliqkvkaskt....pvivHcvdGiSrsAalaaii

MGIRSLNNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVH
.|   . . .  | .   . .|| ||   |..  .. || 
lgyQkiaetsgsvkledvlkalrkqralaitsalelafvd
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 115-225 6.9e-20 66.0 In-house 48-174 (350) alignment 
Range on Protein: 115-225
Range on HMM: 48-174/350.0
AMKNRYTNILPTPATRVPLS--QIGPDA------LSTYMNANFVDGY----NQPKEF--IATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCH
  ||||.||||   .|| |      .||       . |.|||..       ..  .|  ||||.| |.|||||.... .   .|....|   | .. ||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

RYWPEHTEAP--LDTQNFQISIASTEN
|||.| .     .  .. . .|.....
rYWqegsydditvklaskwenimgind
Y_phosphatase Protein-tyrosine phosphatase 116-346 3.1e-76 251.3 Pfam-A 3-233 (235) alignment 
Range on Protein: 116-346
Range on HMM: 3-233/235.0
MKNRYTNILPTPATRVPL-SQIGPDAlstYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQ
 ||||..|||   ||| | .. ||     | |||.|.||...|.||||||| ..|..|||||||.....|.||.|   | || ||..||||..| .| ..
kknRykdilpydktrvklkgsegpsd...YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

NFQISIA-STE-NMKHYILTKLTLEHRASG-ATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNN
.... .  ... ..|.|.|.||.|.....  ..| |.....||||||||| .. ...||...|.. ....  | |||||||.||||||.|.|. ...|..
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea

pH-RvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAM
 .   |||.  . .||.|| |..|.. || |...|.
.eee.vdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 116-346 3.1e-76 251.3 In-house 3-233 (235) alignment 
Range on Protein: 116-346
Range on HMM: 3-233/235.0
MKNRYTNILPTPATRVPL-SQIGPDAlstYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQ
 ||||..|||   ||| | .. ||     | |||.|.||...|.||||||| ..|..|||||||.....|.||.|   | || ||..||||..| .| ..
kknRykdilpydktrvklkgsegpsd...YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

NFQISIA-STE-NMKHYILTKLTLEHRASG-ATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNN
.... .  ... ..|.|.|.||.|.....  ..| |.....||||||||| .. ...||...|.. ....  | |||||||.||||||.|.|. ...|..
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea

pH-RvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAM
 .   |||.  . .||.|| |..|.. || |...|.
.eee.vdvlqivkelRkqRpgmvqsleqYiflykai
0037934 (Phosphotyrosine protein) phosphatases II 116-349 3.6e-67 221.7 In-house 12-241 (243) alignment 
Range on Protein: 116-349
Range on HMM: 12-241/243.0
MKNRYTNILPTPATRVPLsqigPDalSTYMNANFVDGYnqPKeFIATQGPKPETVDD----FWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPehtE-Ap
 ||||..||| . .|| |    ..  | | |||.....  |. .|||||| ||||.|    ||||.||....|.||.|   | ||.||..|||   .   
sknrysdilpydhsrvkl....eg..sdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gev.

lDTQNFQISIASTENMKHYILTKLTLEHRA-SGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRA--------RTDRALPAVVHCSAGIGRTGTFLA
    .|.. . |.|....|....|.||.   .. || | |.....||||||| ..  ..|....||            |.  | .||||||.|||||..|
.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtlia

VDMGIRSLnnphRvVDVFGDMIKLRTQRGG-SIQTFVQYLFVHQAMKDY
 .. .. |    . ||..  . .||.||.| ..||. || |...|.. .
aylmllll....g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 116-355 5.2e-59 194.6 In-house 49-283 (287) alignment 
Range on Protein: 116-355
Range on HMM: 49-283/287.0
MKNRYTNILPTPATRVPLSqigpDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEapLDTQN
 |||.|.||.    ||.|     .    |.|| |.|||.. |.||....|  .|. .||..... . ...||..  .|  . .|..||||..   .   .
dknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGe

FQISIASTENMKHYILTKLTLEHRA-SGATRAVSHFWFTNWPDHG-VPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNpH
..|.. . | ...||  || ....  .|... |  . .|||...| |..    .. . . ..  |     . |||||...||...|.|....|.  ..  
yniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckt.e

RVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVTPGNS
 |.|||  . . | |. ||.||  || |. ...  |.. .. 
GviDvfqvlksqriqkpgsvqtveqykfindivleyldsfet
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 116-346 1.5e-51 169.9 In-house 9-236 (239) alignment 
Range on Protein: 116-346
Range on HMM: 9-236/239.0
MKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYN-QPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEaplDTQ
 ||||.||.    .|| | ..  |  | |.||...  |.  || .|||||    .  |||||.|. |  |.||.||. || . |||.|||. |       
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts...kyc

NFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNpHR
|.....  || .  ||.  . . .      | | .. || |||.|||. .  |. | . . .     | | |.|||||.||||.|| .|  .|  .. ..
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk.qk

VVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAM
 ||.|  .  .| .|   .||  ||.|.| |.
tvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 116-346 1.7e-51 169.7 In-house 10-237 (239) alignment 
Range on Protein: 116-346
Range on HMM: 10-237/239.0
MKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYN-QPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEaplDTQ
 ||||.||.    .|| | ..  |  | |.||...  |.  || .|||||    .  |||||.|. |  |.||.||. || . |||.|||. |       
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts...kyc

NFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNpHR
|.....  || .  ||.  . . .      | | .. || |||.|||. .  |. | . . .     | | |.|||||.||||.|| .|  .|  .. ..
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk.qk

VVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAM
 ||.|  .  .| .|   .||  ||.|.| |.
tvdifnyvkairedrphmvqtseqyvfihlav
subfamily_CG7180_pd Subfamily CG7180 116-350 9.5e-48 157.3 In-house 44-290 (296) alignment 
Range on Protein: 116-350
Range on HMM: 44-290/296.0
MKNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRiKCHRYWPEHTeaPLDTQN
 |||. ...|   .|| |.... .. | |.|| .||.. ..||.| |..|| ||||.|||.|..  .. ||..|   .  . ... |||...    . ..
eknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqyge

FQISIASTENMKHYILTKLTLEHR----------ASGATRAVSHFWFTNWPD-HGVPHETWEVIDLVKAVRRART-----DRALPAVVHCSAGIGRTGTF
. . | ..... .    .. | ..           .  || | .| .| |.  . ||  |  .|.|.. ||  |      .   | ||..| | .|.| .
ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvy

LAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
||.|. .  ... .  ||||. . .|| .| . ...  .| .. . ....|
laidanlelvek.eeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 116-349 1.4e-45 150.2 In-house 58-282 (290) alignment 
Range on Protein: 116-349
Range on HMM: 58-282/290.0
MKNRYTNILPTPATRVPLSQIGPdalSTYMNANFVDGYNQPkeFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQN
 |||| ..     ||| |.. ..     |. ||.|.| . .  || |||.  .|| |.|||| . .  ..||.  . | |. ||..|.||.    |   .
kknrykdvvcndktrvilkdGyd...GdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

FQISIA-STENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTdralPAVVHCSAGIGRTGTFLAVDMGIRSLNNPhR
. .  . .... .. |.  |.. .. ||    . |.    |||. |.  |  .. .....|.|      | |||||||||||||| |...|.. | .  .
itvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasG....pvvvhcsaGiGrtGtfvaievglqilldG.k

VVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDY
 .|. . .  ||  | .|.|  .||| . ... |.
eldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 116-350 1.7e-41 136.9 In-house 57-289 (305) alignment 
Range on Protein: 116-350
Range on HMM: 57-289/305.0
MKNRYTNILPTPATRVPLSQIGPdalSTYMNANFVDGYNQP-KEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQ
 ||||...     . | |..  |   | |. ||.|     | | ||..|||  .|.|.|| || . . | .||.    | |..|| .|||      |. .
tknryqdvpcqdqsavkldkpsp...sdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelk

N--FQISIASTENMKHYILTKLT---LEHrASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARtdraLPAVVHCSAGIGRTGTFLAVDMGIRSL
.      .. .  |.     ..|   | . . . . .| |. .|.||| |||      ..|. |.| ..    .| ||||||||||||| .|..  .  .
sgivvenvsgskpmerdaeiqitllnlty.sgdqkmsvrhlqwtewpdrgvppckltslellsairgsk....vpivvhcsagigrtgtivaieyileki

NNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
 . ...  .   .  || ||  |||. |||||.|. | .|.
aenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 116-267 6.1e-37 122.1 In-house 35-186 (297) alignment 
Range on Protein: 116-267
Range on HMM: 35-186/297.0
MKNRYTNILPTPATRVPLSQIGPDalSTYMNANFVDGYNQPK--EFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDT
 ||||..|| |  ||| | .  ..  . |.||..|   ....   .| .|||  .||||||..|.|    |.||.. ..|.|| ||  |||.  .  | .
rknryrdilatddtrvkllrvite..rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlka

QNFQISIAST--ENMKHYILTKLTLEHRasGATRAVSHFWFTNWPDHGVPHETWEV
 .. .   |.  .. .. |||.|.| .|    .| | |  | .||||||| .  ..
gdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 116-350 8.9e-33 108.5 In-house 45-271 (288) alignment 
Range on Protein: 116-350
Range on HMM: 45-271/288.0
MKNRYTNILPTPATRVPLSqigpDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDT-Q
 ..||.|.    .||| ||    |    |..|| |   . .. .| .| |   |.. .|.|. |   | .||.. . | |. |   |.| .        .
trdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigr

NFQISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVrrarTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHr
. ..   . ..... .   |   ..    .  | .  . .|.|.|||..    . |.. .     .   | |||.|||.|||||.  . . ..||  .  
lctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialeslrldd.

VVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
 . .   . ||| .|  .|||  |||.||. .....
flgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 116-347 3.6e-30 99.6 In-house 54-287 (310) alignment 
Range on Protein: 116-347
Range on HMM: 54-287/310.0
MKNRYTNILPTPATRVPLsQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEH----TEAPL
 ||||....   ..|| | .|       |. ||.|      . || .|||   |. |||||... |.| ....  . | || ||  |||      |   .
hknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygci

DTQNFQISIASTENMK---HYILTKLTL-EHRASGATRAVSHFWFTNWPDHGVPHETWEVIDlvkaVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIR
   |.  |    |  .    ..  .. . |  |      ||   . |||| ||| |    .      |     |  | |||||||..|... .|... | 
rvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp....qrllaqvrhgpcvvhcsagkdrlyvvvalklkid

SLNNPHRvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMK
 |.. .. ||.   . .|. .|   ||| .|||.... . 
kldrglk.vdaeevktellksraiciqtelqyliidrvri
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 116-351 5e-16 53.2 In-house 49-280 (303) alignment 
Range on Protein: 116-351
Range on HMM: 49-280/303.0
MKNRYTNILPTPATRVPLSQigpdalSTYMNANFVDgYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEApLDTQN
 |||.....    ..| ||.      |.|. |....  .  |  | || | . |  |||.|. | .  .|...    |  ..  .  .|.  .  |. ..
dknrfvdvicldhskvklsd......ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf.lkfee

FQISIAS---TENMKHYILTKLTLehrASGATRAVSHF-WFTNWPDHGVPHE----TWEVIDLVKAVRRARTDrALPAVVHCSAGIGRTGTFLAVDMGIR
  | .      | .. . |  |..   . |  ..  |   . .||   .| .        |  ...| |  .| . |.|    .| ||.|||   .    
rsirvgefkrvelgdgwvlkvlsv...sngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysd.stptvymslsgcgragtfalfetahl

SLNNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
|| .    .|.   . ..|  |  ..| . |. .|.  . ..| 
slhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 116-207 8.1e-12 39.1 In-house 50-157 (349) alignment 
Range on Protein: 116-207
Range on HMM: 50-157/349.0
MKNRYTNILPTPATRVPLSQIG--------------PDALSTYMNANFVD--GYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKC
 |||| .|||   .|| | .                   |  |.|||..    ..  | .|||| | | |||||....   . ..|. ..   | .  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HRYWPEHT
..|| | .
diywqels
0042113 (Phosphotyrosine protein) phosphatases II 117-350 9.2e-75 246.5 In-house 12-243 (245) alignment 
Range on Protein: 117-350
Range on HMM: 12-243/245.0
KNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEhtEAPLDTQNF
||||..||| . ||| || .|.|  |.| ||..||||.... ||||||| ||||.|||||.||......||.|   | ||.||..|||.  . .| . .|
knrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..gesltygdf

QISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRART-DRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPhRV
..   |.|....|....|....  .. .| | |.....|||||||. .  ..|....||.|.  |.  | .||||||.||||||.|... .. |.   . 
tvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqleke.lg

VDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
|...  . .|| ||.|..||. || |...|.....
vsleeavkelrsqRpgavqtpsqyrflyeallell
0040439 (Phosphotyrosine protein) phosphatases II 117-350 1e-74 246.5 In-house 14-246 (249) alignment 
Range on Protein: 117-350
Range on HMM: 14-246/249.0
KNRYTNILPTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEhtEAPLDTQNF
||||..||| . .|| || ..   || | ||...|||.....||||||| ||||.|||||.||....|.||.|   | ||.||..|||.  . .|   .|
knrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggsleygdf

QISIASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTD--RALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHR
..   |.| ...|....|.|..   | .| | |...|.|||||||  . ...|...||| |...  .  | .||||||.||||||.| .. .. |.  ..
tvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelg

vVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
 ||..  . .||.||.|..|.. || |...|.....
.vdleeavkllrsqRpgavqnpeqyrflyeallell
0041856 (Phosphotyrosine protein) phosphatases II 117-350 4.4e-46 152.1 In-house 4-171 (182) alignment 
Range on Protein: 117-350
Range on HMM: 4-171/182.0
KNRYTNILPTPATRvplsqigpdaLSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTgireggrikCHRYWPehteapldtqnf
||||..||| . .|           ..| |||...|.  ...||||||| ..|| ||.||..|..  ..|..|         ...|||            
knrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp............

qisiastenmkhyiltkltlehraSGATRAVSHFWFTNWPDHGVPHeTWEVIDLVKAVRRartdRALPAVVHCSAGIGRTGTFLAVDMGIRSlnnphRvV
                        .  .|.. ......|||||||  . |..|....|..    .  | .||||||.|||||. | .. ..      . |
........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....g.v

DVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
...  .  .| .| |...|  || |...|. ...
sleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 117-342 2.7e-38 126.4 In-house 53-273 (301) alignment 
Range on Protein: 117-342
Range on HMM: 53-273/301.0
KNRYTNILPTPATRVPLSQigpDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQNF
|.|| ..   | | | . .   |     . ||...   .|. ||||||| ..| .||| |.  |  | .||..  .|    ||. | | ...  || . |
khryptvPckPstaveviv...dGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrf

QISIASTENMKHYILTKLTLEHRASG---ATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTdralPAVVHCSAGIGRTGTFLAVDMGIRSLNNpH
.| | ..| . .  ..| ||| . |    |||.| |. ...|.|.|||.   |. ||.. |....     | ||||||||||. .|.. ..  | ... .
kikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek....PivvhcsaGiGrsvafigteylarevea.d

RVVDVFGDMIKLRTQRGGSIQTFVQYLFV
. ...   . .|| .|  ..||  |  ..
ptieltealkhlrehrwngvqtnsqlywm
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 118-350 7.9e-32 105.4 In-house 39-270 (285) alignment 
Range on Protein: 118-350
Range on HMM: 39-270/285.0
NRYTNILPTPATRVPLSQIGPDalstYMNANF--VDGYNQpKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQN
|||...     ||| | .   |    |. |..  . | .|   .|.|||| |||. |||.|... .   |.|.  . |||  ||  |.||.    .   .
nryadvrcieetrvvlknhdrd....yihaswmrmpgkdq.styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgk

FQISIAS--TENMKHYILTKLTLEH--RASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTdRALPAVVHCSAGIGRTGTFLAVDM-GIRSLN
..|...    | .   ||  ||.     ||     . |     |||.  | ..  .|.| | |..    .  | .||||||.||| ||. .|   || ..
yeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp.kekpicvhcsagvgrtatfvgidyatirime

NPH-RVVDVFGDMIKLRTQrggSIQTFVQYLFVHQAMKDYV
||   ..|.  .|  .| |   ..|...|.||..  . .|.
npniemldivremramrfq...avqshmqflflyvvlmeyf
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 118-350 3e-30 100.0 In-house 47-276 (312) alignment 
Range on Protein: 118-350
Range on HMM: 47-276/312.0
NRYTNILPTPATRVPLSqiGPDalSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTE---------
||| ||      |  |.  | .    |. ||||    .|. |..||||  .|.  ||...    |  .....|. | |  || .|  .            
nrypniqcwdrgrftla..gde..nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

APLDTQNFQISIASTENMKHYILtklTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTdralPAVVHCSAGIGRTGTFLAVDMGIRS
      . .|   | ... | .|    .  .|.|    . |. .. |||||.|        |. ||.. .     | . |||||.|||||.  ..  | .
yteycteieiggkskdkithrvl...kvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk....pviahcsagvgrtgtlaliesmiaa

LNNPHRvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYV
|  | .  .|   .. || .|  |...| ||... ... ...
lrhprk.qnvkdsfvllrkdrarsvrvfpqyvyalrcvlefl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 123-186 2.4e-09 31.2 In-house 46-114 (347) alignment 
Range on Protein: 123-186
Range on HMM: 46-114/347.0
ILPTPATRVPLS----QI-GPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVV
   . |||| ||    .    |   ||.||  .   |  ||.| || | |.|| |||.||   .   ||
vklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv
subfamily_egg_pd Subfamily egg 125-346 3.9e-27 89.7 In-house 51-266 (307) alignment 
Range on Protein: 125-346
Range on HMM: 51-266/307.0
PTPATRVPLSQIGPDALSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGgrIKCHRYWPEHTEAPLDT--QNFQISIAS
    .|| |       |  .. || |.|     ||| .| |  .|||||||||.. . . .||.|  .|    .|. |||   . .| |   ...|    
ckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlk

TENMKH--YILTKLTLeHRASGATRAVSHfWFTNWPDHGVPHETWEVIdlvkavRRARtDRALPAVVHCSAGIGRTGTFLAVDMGIRSL-NNPHRVVDVF
 ..     . .||| |   .    | . | |  ..   .  .   .|.      |..| . . |.||..  |. ...|..|... . ||   |     | 
vdskadplfrvtklkl.vGgddeerfleh.wqgdvnnssdvysplrvl......rklr.nlskpvvvqdilGvskaatlvaieiallsllrGpitkslvl

GDMIKLRTQRGGSIQTFVQYLFVHQAM
  .  || .|  |... ..||||.. .
ravvflrlrrrlsvesvllylfvyrlv
0044763 (Phosphotyrosine protein) phosphatases II 126-347 6.2e-29 96.3 In-house 2-168 (178) alignment 
Range on Protein: 126-347
Range on HMM: 2-168/178.0
TPATRVPLSQIGPDALSTYMNANFVDGYnqpkEFIATQGPkpetvDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEapldtqnfqisiasten
 . ||| || .     | |.||......     ......|      |......|.   ..|..|.  |.|..||..|||| ..                 
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

mkhyiltkltlehrasgatravSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSlnnphRVvDVFGDMIKL
                       .. ....||||||  .. . ..|.....|. ..  | .||||||.||.||. | .. ..      .. ...  .  .
......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....gl.sleeaielv

RTQRGgSIQTFVQYLFVHQAMK
| .|   .... |. ....  .
rerRp.ivpnpgqlrqLyefel
0046846 (Phosphotyrosine protein) phosphatases II 135-349 1.7e-42 140.5 In-house 5-172 (176) alignment 
Range on Protein: 135-349
Range on HMM: 5-172/176.0
QIGPDALSTYMNANFVDGYnqpkEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLdtqnfqisiastenmkhyiltkl
..|.|  ..| |||...|.     .|||||| |.|. ||..|..|.. ..||..|  .| ||.||..|||| ... .                       
llgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

tlehrasgatravsHFWFTNWPDHGVPHEtWEVIDLVKAVRRARTDRaLPAVVHCSAGIGRTGTFLAVDMGIRslnnpHRVVDVFGDMIKLRTQRG-GSI
              ......|||||||     ...|....|.|...   | .||||||||||||..| .. ..     .. ..|.  . ..| ||  |..
..............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel.....ekglsveealalvreqRplgav

QTFVQYLFVHQAMKDY
||. || |...... .
qtpeQyrflyefelll
0051429 (Phosphotyrosine protein) phosphatases II 141-351 3.4e-50 166.5 In-house 3-226 (272) alignment 
Range on Protein: 141-351
Range on HMM: 3-226/272.0
LSTYMNANFVDGYNQ---PKEFIATQGPKPETVDDFWRMvWEYRSEVVVMMTGIREGGRIKCHRYWP----------EHTEAPLDTQNFQISIASTENMK
||.| ||..|.||..   |. .....|| | |..||||. .|..  ..|....  | || ||.||||          .... .    .. . . |.|.. 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

HYILTKLTLEHR-ASGATRAVSHFWFTNWPDHGVPHETweVIDLVKAVRRartdrALPAVVHCSAGIGRTGTFLAVDMGIrSLNNPHRVVD--------V
.|||..|.|..    |..| | |...|.|||||||.|.  ...|......       | .||||||..||||. |... .    . . .||        .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyl

FGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
.. . .|| || |..||  ||||...|..... 
eeaveelraqrpgavqteeqylflyeallellr
0043147 (Phosphotyrosine protein) phosphatases II 141-345 4e-42 139.2 In-house 4-156 (172) alignment 
Range on Protein: 141-345
Range on HMM: 4-156/172.0
LSTYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIreggrikchrywpehteapldtqnfqisiastenmkhyiltkltlEHRA
 |.|.||...|.|  |..||||||| ..|..|||||..|.   ..|..|.                                              .. .
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lydp

SGATRAVSHFWFTNWPDHGVPhETWEVIDLVKAVRR-ARTDRALPAVVHCSAGIGRTGTFLAVDMGIrslnnphRVVDVFGDMIKLRTQRGGSIQTFVQY
.. .| . ......|||||||  .  ...... ... .  ..  | .||||||.|||||. | .. .       . ....  .  .|..|.|..|.. ||
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqnpsqy

LFVHQA
 |... 
rflyyf
0051082 (Phosphotyrosine protein) phosphatases II 141-345 2.4e-33 110.2 In-house 2-148 (151) alignment 
Range on Protein: 141-345
Range on HMM: 2-148/151.0
LSTYMNANFVDGYnqpkeFIATQGPKPetvdDFWRMVWEYRSEVVVMMTGIREGGriKCHRYWPEHTeapldtqnfqisiastenmkhyiltkltlehra
||.| |...|.|.     .....|| .    ||.....|.   ..|....  | |  .|..|.||.                                  
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

sgatRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRartDRALPAVVHCSAGIGRTGTFLAVDMGIRSlnnphrvVDVFGDMIKLRTQRGGSIQTFVQYL
    . | |.....|||.|.|. . .|.........   ..  | .||||||.|||||. |... ..        |...  .  .| .|.|..|.. |.|
....ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqfl

FVHQA
|...|
fqlfa
0036282 (Phosphotyrosine protein) phosphatases II 142-344 1.8e-45 150.1 In-house 2-164 (174) alignment 
Range on Protein: 142-344
Range on HMM: 2-164/174.0
STYMNANFVDGYNQPKEFIATQGPKPetvddFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEhteapldtqnfqisiastenmkhyiltkltlehRAS
|.|.||...|..  ....||.||| .     ||.|..|.....|||..  .| |. ||..||||                                 . .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

GATRAVSHFWFTNWPDHGVPHETWeVIDLVKAVRRARTD-RALPAVVHCSAGIGRTGTFLAVDMGIRSLNnpHRVVDVFGDMIKLRTQRGGSIQTFVQYL
  .| . ......|||||||  .  ....||.|..|. . .  | .||||||.|||||. | .. .| |   ...||..  . .||.||.|..||. || 
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtpsQyr

FVHQ
|...
flyy
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 142-260 2e-12 41.6 In-house 13-126 (130) alignment 
Range on Protein: 142-260
Range on HMM: 13-126/130.0
STYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGgrikcHRYWPEHteAPLDT--QNFQISIASTENMKHYILTKLTLEHR
 ||.||.||   .. .|.. || |  .|  |||.|. |   .|.|..  . |        |||.    ||.   ..  ....  ...|.   ..|  |. 
ntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpds..ePlewyeediivtltdrdefknikasnleiesd

ASGATRAVSHFWFTNWPDHGV
   . .|.. |  .|||  | 
lneshqaltmfqisnwpsdgt
subfamily_eak_pd Subfamily eak 142-262 4.2e-12 40.1 In-house 78-196 (332) alignment 
Range on Protein: 142-262
Range on HMM: 78-196/332.0
STYMNANFVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQNFQISIASTenMKHYILTKLTLEHRAS
  |.||  ..  .  ...| |  .. . |  ||.|| | .|  .|..    | .  |  .|.|..|   |.   ...   .   .|. ||    || .  
lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkef..vkrniletrllelskG

GATRAVSHFWFTNWPDHGVPH
  |  | |. .  | .  .| 
nethrvlhykvfGwtettlpk
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 144-350 1.4e-18 61.3 In-house 77-285 (302) alignment 
Range on Protein: 144-350
Range on HMM: 77-285/302.0
YMNANFVDGYNQPKEFIATQGPKPETV---DDFWRMVWEYRSEVVVMMTGIREGGRiKCHRYWPEHTEAPLDTQNFQISIASTENMKHYIlTKLTLEHRA
|.||  |.  .  .. | .| || ...   ..|||||.. .   ||.. |  |  .   . ..|..... .. ... . .   |...    |....|   
yvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlP

SGATRAVS--HFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPhRVVDVFGDMIKLRTQRGGSIQTFVQ
 | . .|      .|||... || .  |.|  .. |    ..   ..|.    |.|| |.||.. . . .|..    . .   ....|.||  ..... |
egcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkg.kepnikeivksiRsqRpravdslkQ

YLFVHQAMKDYV
| ... |.  |.
yvslyialllyi
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 145-342 7.5e-25 82.0 In-house 78-280 (302) alignment 
Range on Protein: 145-342
Range on HMM: 78-280/302.0
MNANFVDGYNQPKEFIA-TQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQNFQISIAST-ENMKHYIL----TKLTLEH
|    .|| .. ..       || .|.. .| .. .|.  .|| .... |..  ||  |. .. .  |  ... .   |  ......      .  |.| 
maqGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytvei

R----ASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDralpAVVHCSAGIGRTGTFLAVDMGIRsLNNPHRVVDVFGDMIKLRTQRGGSIQ
.     .   ..|. . |. ||||| |.|.   .|..|     ...     .||||||.|||||..|.  ||  |   ..| |.   .. .|. | |..|
knekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiq.lcskkkvtdllsivlpvrqcryGavq

TFVQYLFV
.  | ...
deqqliyl
0049260 (Phosphotyrosine protein) phosphatases II 149-344 8.5e-40 131.3 In-house 1-144 (152) alignment 
Range on Protein: 149-344
Range on HMM: 1-144/152.0
FVDGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWpehteapldtqnfqisiastenmkhyiltkltlehrasgatravs
|.|||..|.|||||||| |.|..|||||..|.   ..||.|   | |..||..|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

HFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIrslnnphRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQ
.. ...|||||||  .  ...|........ |.  | .||||||.|||||. | .. .       . |...  .  .|..| |..... |. |...
qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 151-237 1.5e-10 35.0 In-house 230-312 (440) alignment 
Range on Protein: 151-237
Range on HMM: 230-312/440.0
DGYNQPKEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGgriKCHRYWPEHTEApLDTQNFQISIASTENMKHYILTKLTLE
.|| . . ||||| |   || ||||.| .||   ..|.  . .     |  |||  | . .    | .    .|||.   .  | | 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrs.vtfgpftvghkgsenmnrvkvrtlelk
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 157-344 1.2e-28 94.7 In-house 5-198 (199) alignment 
Range on Protein: 157-344
Range on HMM: 5-198/199.0
KEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQNFQISIASTENMKHYILTKLTLE--HRASGATRAVSHFWFTN
. .|||| |  ||. |||.||||  |  .||.   .         |||    .     .. ..  .      | .| | |     |  .|| .||. || 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPHETWEViDLVKAVR----RARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPH-RVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQ
| ..  |  .  |  .| | |    .   ..  | .|||| | | || |.|.|.|.|| .. .  |||.|    .||  | | | .. .| |..|
wkekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 157-344 1.2e-28 94.6 In-house 4-197 (198) alignment 
Range on Protein: 157-344
Range on HMM: 4-197/198.0
KEFIATQGPKPETVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQNFQISIASTENMKHYILTKLTLE--HRASGATRAVSHFWFTN
. .|||| |  ||. |||.||||  |  .||.   .         |||    .     .. ..  .      | .| | |     |  .|| .||. || 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPHETWEViDLVKAVR----RARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPH-RVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQ
| ..  |  .  |  .| | |    .   ..  | .|||| | | || |.|.|.|.|| .. .  |||.|    .||  | | | .. .| |..|
wkekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 169-355 1.9e-24 81.2 In-house 40-226 (255) alignment 
Range on Protein: 169-355
Range on HMM: 40-226/255.0
TVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQNfqISIASTENMKHYILTKLTLEHRAS--GATRAVSHFWFTNWPDHGVPHETWE
||| |....   ..|||||..   | |. ||..|.|   .  |  ..  .....|... . .|  |..    .    |. | |. .. |...  |... |
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklklad..vnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

VIDLVKAVRRARtdralPAVVHCSAGIGRTGTFLAVDMG----IRSLNNPHRVVDVFGDM-IKLRTQRGGSIQTFVQYLFVHQAMKDYVTPGNS
.  ..|.|| ..     . |||||.||||. .|  ...     ||||.. . |   .  .  .|| .| ..|.| .|  |    . |.| | . 
ilnilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkge
subfamily_hpo-7_pd Subfamily hpo-7 169-354 2e-20 67.8 In-house 46-231 (263) alignment 
Range on Protein: 169-354
Range on HMM: 46-231/263.0
TVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQNfqISIASTENMKHYILTKLTLEHRA--SGATRAVSHFWFTNWPDHGVPHETWE
|.| |....   ..|||||..   | |. || .|.|   .  .  .|  .....|. ..  .|  | |         |. | |. .. |...  |... |
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklan..vnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelare

VIDLVKAVRRARtdralPAVVHCSAGIGRTGTFLAVDM----GIRSLNNPHRVVDVFGDMI-KLRTQRGGSIQTFVQYLFVHQAMKDYVTPGN
.. ..|..|  .     . |||||.||||.  |  ...     ||||.. . |   .  .. .|| .| ..|.| .|  |    . |.| . .
ilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnf
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 169-351 2.4e-07 23.7 In-house 130-310 (346) alignment 
Range on Protein: 169-351
Range on HMM: 130-310/346.0
TVDDFWRMVWEYRSEVVVMMTGIREGGRIKCHRYWPEHTEAPLDTQNFQIS--IASTENMKHYILTKLTlEHRASGATRAVSHfwFTNWPDHGVPHETWE
 |.||| |... . ..| .|             .  |        . |        . . | | .  |  |  .      | |   . |     |  |  
fvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlp.egnsdsvicqvhh..hapwkhlqqppktlp

VIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHRvVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDYVT
.| ...     .  ...   |    | ||. .|.     |. |||     ...  | ... || |....| ||  ..  . ||..
iikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngie.pniceimknikqqrpggvesfaqyasiyaivfdyia
0038934 (Phosphotyrosine protein) phosphatases II 218-342 8.9e-09 30.8 In-house 47-169 (194) alignment 
Range on Protein: 218-342
Range on HMM: 47-169/194.0
ISIASTENMKHYILTKLTLEHRA---SGATRAVSHFWFTNWPDHGVP---HETWEVIDLVKAVRRARTDRalPAVVHCSAGIGRTGTFLAVDMGIRSLNN
..  .. |.|.. .  || ..|    .  ..|  ..    .||.|..     ... .|||. . .. ..     .||| ||.|||||..|  .  |   .
vrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpgg..vvaVHCkaGlgRtGtlvaaYLiyrlgms

PHRVVDVFgdmiklRTQRGGSIQTFVQYLFV
..  .. |      |  |.|.|..  ..  .
aeeAialf......rekRpgaipnqdyleal
0048179 (Phosphotyrosine protein) phosphatases II 220-344 5.2e-21 70.3 In-house 22-139 (144) alignment 
Range on Protein: 220-344
Range on HMM: 22-139/144.0
IASTENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRaLPAVVHCSAGIGRTGTFLAVDMGIrslnnpH-RvVDV
..   ..... .  || |.     .| . ......|||||||  .  ..........|. .   | .||||||.|||||. | .. .      . . ...
lellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk......klg.lsl

FGDMIKLRTQRGGSIQTFVQYLFVHQ
.  .  .|..| |..... |. |...
eealalvrsrrpgavpnpgqlrfLle
0048076 (Phosphotyrosine protein) phosphatases II 223-348 1.2e-22 75.5 In-house 23-141 (145) alignment 
Range on Protein: 223-348
Range on HMM: 23-141/145.0
TENMKHYILTKLTLEHRASGATRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRaLPAVVHCSAGIGRTGTFLAVDMGIRslnnpHRvVDVFGDM
 .  .. | | |.| .  .. .| . ......|||||||  .  ..........|. .   | .||||||.|||||. | .. ..     .. |...  .
ellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lg.vsleeal

IKLRTQRGGSIQTFVQYLFVHQAMKD
 ..|.|| |..... |. |.... . 
elvrsqrpgavpnpgqlrflyefele
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 244-364 2.3e-16 54.2 In-house 88-208 (440) alignment 
Range on Protein: 244-364
Range on HMM: 88-208/440.0
TRAVSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTD-RALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHRvVDVFGDMIKLRTQRGGSIQTFVQYLFV
.|.. .. .  |||.|||. .  |. ... |  ..      | .|||||| ||||  .|||  .|  .   . .|.|  .  .| .|   .||  || ||
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdq.idifsfinsmrnnrpqmvqtpeqyafv

HQAMKDYVTPGNSFGMFGDNTS
|.|. . .  |... .  | | 
heavlegllcgdtlileddite
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 244-350 2.9e-13 44.3 In-house 214-344 (350) alignment 
Range on Protein: 244-350
Range on HMM: 214-344/350.0
TRAVSHFWFTNWPDHGVPHETWE----------VIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIR------SLNNPHRVVDVF---GDMI-
   | .. . ||.| ..  .  .          .||   |     ..|. | .||||||.|||||....|. .        |..  | .||     |.| 
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlis

----KLRTQRGGSIQTFVQYLFVHQAMKDYV
    .|| ||   .|.  |..|...|.. | 
iivnelrkqrismvqnldqfifiYeallfyf
PTPc_DSPc_SM00012 247-347 1.1e-31 104.6 In-house 2-104 (105) alignment 
Range on Protein: 247-347
Range on HMM: 2-104/105.0
VSHFWFTNWPDHGVPHETWEVIDLVKAVRRARTDRA--LPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQ
|.|...|.|||||||.|. ....|..||.. .....   | |||||||.|||||| |.|. ...|.. .. ||.|  . .||.|| |..||. ||||...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AMK
|..
all
subfamily_PTPDC1_pd Subfamily PTPDC1 250-346 1.5e-08 29.3 In-house 85-172 (182) alignment 
Range on Protein: 250-346
Range on HMM: 85-172/182.0
FWFTNWPDHGVPHETwEVIDLVKAVRRARTDRalPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHRVVDvfgdmiKLRTQRGGSIQTFVQYLFVHQAM
..   |.|.||.  . ...|.|| |  | ..      ||| || ||||  .|. .   .  .... ..      ..| .|  ||||  |  .|.. .
vynfgwkDygvasle.riLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltaekaik......lvrskrpksiqtreqvelvkefa
subfamily_DSP23_pd Subfamily DSP23 263-344 3.8e-06 21.6 In-house 66-140 (148) alignment 
Range on Protein: 263-344
Range on HMM: 66-140/148.0
ETWEVIDLVKAVRRARtDRALPAVVHCSAGIGRTGTFLAVDMgIRslnnpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQ
   .| ..|. |  |  ...    |||  | |||||.||  . ..     .| .     . ..| .| ||..|. |   |..
aleqvvefvrvveeae.ekneavsvhcllgrgrtgtmlacyl.vk.....erklaaaeaiaevrrlrpgsvetveqeklvrd
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 266-310 1.6e-07 25.0 In-house 249-293 (349) alignment 
Range on Protein: 266-310
Range on HMM: 249-293/349.0
EVIDLVKAVRRARTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLN
..||   |     ||.  . .|||||| ||||..  .|. .  |.
dliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsile
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 276-346 6.6e-11 36.6 In-house 222-291 (297) alignment 
Range on Protein: 276-346
Range on HMM: 222-291/297.0
RARTDRALPAVVHCSAGIGRTGTFLAVdMGIRSLNNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAM
||   | .. .||||||.||.|  .   . | .    .|. ||   . .|| ||   .||. |. ....|.
raemprnayllvhcsaGvGrsGvvvls.dvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_CG42327_pd Subfamily CG42327 278-349 5.5e-17 56.4 In-house 243-314 (319) alignment 
Range on Protein: 278-349
Range on HMM: 243-314/319.0
RTDRALPAVVHCSAGIGRTGTFLAVDMGIRSLNNPHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKDY
. ..  | ||||| |.||||. .| |. ||||....| ||.   .  .| .|. ...|  || |... .  |
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 286-347 2.3e-10 34.7 In-house 2-62 (69) alignment 
Range on Protein: 286-347
Range on HMM: 2-62/69.0
VVHCSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMK
|||||.| ||||||.|. . .  .    ..||.| ..  .|  |   .   ..|.|.| |. 
vvhcssgtgrtgtfiaimvemariks.eklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 286-348 8e-10 32.9 In-house 1-62 (69) alignment 
Range on Protein: 286-348
Range on HMM: 1-62/69.0
VVHCSAGIGRTGTFLAVDMGIRSLNNpHRVVDVFGDMIKLRTQRGGSIQTFVQYLFVHQAMKD
|||||.| ||||||.|. . .  .    ..||.| ..  .|  |   .    .|.|.|.|. .
vvhcssGtGrtGtfiaimvemariks.eklvdifnnvqymrkcrpmmvmneneymfihdalve
PDZ_2 PDZ domain 365-413 1.8e-06 17.4 Pfam-A 28-76 (82) alignment 
Range on Protein: 365-413
Range on HMM: 28-76/82.0
RDVGVLPGDQILAINQQPVHNLKHAEVAERARQSGGVITLTLLSKKLEE
 . |. |||.||......|..|.. . . .  . |  ..||.| .. ..
akaglkpGDiilkvdgkkvksltdlkslllkkkpGdtvkltvlRdgkkk
PDZ PDZ domain (Also known as DHR or GLGF) 369-406 6.1e-10 29.3 Pfam-A 43-80 (81) alignment 
Range on Protein: 369-406
Range on HMM: 43-80/81.0
VLPGDQILAINQQPVHNLKHAEVAERARQSGGVITLTL
. .||.||..|...| |. |.|...  ....|..|||.
lkeGDkIlsvNgvdvenvshdeavqaikgkkgevtLti