Gene MbrePTP-Un-9 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP063_AA protein Get Run
MbreP063_AA_691-985 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
GF_recep_IV Growth factor receptor domain IV 97-186 2.8e-09 23.2 Pfam-A 10-98 (132) alignment 
Range on Protein: 97-186
Range on HMM: 10-98/132.0
RCVGPALDECTKCQpdaGFLLETTCVASCPISTFAQGTNDDasGRTCQDCAPGC------AQCS--NPTTCTACLPNWyiglDNATCVQACPNGFGGQ
 | ||  ..| .|.    |  |..||.|| . .. . .  .   ..|..| | |      . ||  ....|..|        |. .||. ||.|  |.
gCWGpgpeqClsCk...kfsrekeCvescnllegekreyee..ekkCvkChpeCekqeesetCsgpgadeClkCahfk....dgkeCvseCPegvkge
0050432 (Phosphotyrosine protein) phosphatases II 674-988 3.2e-56 186.3 In-house 9-303 (308) alignment 
Range on Protein: 674-988
Range on HMM: 9-303/308.0
VPKWTQMGDKFRGRMTQSRPLNVSQLEASSRDPTMLQSEYESIPPNAASVD---ELPSGVESRNRSPSVLPNIHSRVYLsvdmssdtALRDEYINANYMR
...........   ... . |.. .|  .  |...|. |.| .. .  . .    |     ..||....||. ||||.|           . ||||.|..
lelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl........degsdYInAsyvd

GLG-GVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTR---TIWHQmpvmtthgpkktrkrtirlNDYKIKLVHEAELDHA
|   ...|.||.||.| |.|.||||.|||.|...|.|    |||.|.    .|||.    ....                    ......|..| .||. 
gyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsley...................gkftvtllseevlddy

IYSRIKLWK-GALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRtGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGL
..  ..|.. |    ||.|| ....      |....   . .. |  .. .. |.||||  |. | ..|.|||.|  || ..|. ||...|..||. |  
tvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpg

CINSLEQYRFLHAAAWTFARTHE
.....|||.||. |.  ......
mvqtpeqylflyralleylklkl
subfamily_PTPRA_pd Subfamily PTPRA 693-831 1.4e-18 61.9 In-house 13-155 (330) alignment 
Range on Protein: 693-831
Range on HMM: 13-155/330.0
PLNVSQLEA-----SSRDPTMLQSEYESIPP-NAASVDELPSGVE--SRNRSPSVLPNIHSRVYLSVDMSSDTAlrdEYINANYMRGLGGVDrRFILTQA
|| | .||      |. |  ... |....|  .  .. || |  |   .|| . .||. .|||.|||    ...   .|||| .. |    | .|| .| 
plpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGvees...dyinasfidGykekd.kfiaaqG

PSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIWHQ
|   | |||| |.|.|. . .|    | |      ..|||.  ..  
PkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvty
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 696-980 3.4e-28 93.5 In-house 15-275 (315) alignment 
Range on Protein: 696-980
Range on HMM: 15-275/315.0
VSQLEASSRDptMLQSEYESIPPNAASVDELPSGV--ESRNRSPSVLPNIHSRVYLSVDMSSDtalRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDF
|.| .||...   .. .|||||       .    .    .||   ...  .|||.| .    .     .|.|||.. |     ||.| .|.| ... .||
vaqkkastkn..gfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendp...hsdyvnanfidGyn.kkrryiaaqgpnvasvkdf

WHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIWHQMPVMTTHGPKKTRKRTIRLNdykiKLVHEAELDHAIYSRIKLWKGALGPRTLTHVWMLStgs
| .|...... .|   .|||.      .||| . . .    .|    ..  . |.|        | . .. . .  ..  |  .  |.  . .  |    
wrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtl....svvfgdnirevvqlhytswpdmgvpkytiplmnli...

krepQHARTWNTVVRdvagmrtgsAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
    .... ..|            ...||||  |. |   |..|| .  |.  .   ||   . ..|| |   ....|||.|.. | 
....rtvkqhhtnsv.........gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Ptp69D_pd Subfamily Ptp69D 698-982 2.5e-36 120.4 In-house 12-284 (307) alignment 
Range on Protein: 698-982
Range on HMM: 12-284/307.0
QLEASSRDP-TMLQSEYESIPPNAASVDELPSGV---ESRNRSPSVLPNIHSRVYLSVDMSSDTAlrdEYINANYMRGLGGvDRRFILTQAPSPTTCEDF
.|... ||.   |. |||... .  . .   |       .||.. . .  . || |..   ....   .||||....|     ..||  |.|  .| .||
alksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkeds...dYinasfikgyke.kkkfiaaqdPveatigDf

WHMVWDQECSVVVQCHGLVEDGVAVGTRYWP--TRTIWHQMPVMTTHGpKKTRKRTIRLNDYKIKLVHEAELdhaiysriklwkgaLGPRTLTHVWMLST
| |...||  ..|    | |   .   .|||  . . . .. | . .  .|. . .||  |.  |  . .|.                 | ..    .. 
WRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvse.ekhsdyiiReldvskkkeesgev..............edsrkvvqyhytgW

GSKREPQHARTWNTVVRDV-AGMRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWT
     |..||.   ... |    ..  .|.|||| .| .| ..|||||.|  || .  ..|.  ||..||..| | ..||||| ||. |   
kDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralld
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 701-981 7.2e-35 115.4 In-house 15-276 (288) alignment 
Range on Protein: 701-981
Range on HMM: 15-276/288.0
ASSRDPTMLQSEYESIpPNAASVDELPSGVESRNRSPSVLPNIHSRVYLSVDMSS-DTALRDEYINANYMRGLGGvDRRFILTQAPSPTTCEDFWHMVWD
.| |. | ...||.|. ..  . ..   | ...| .    .|| .  .  | .   ..    .||||.|. | .. ....| ||.| . | .|||..|..
ksarnrtgfseeynsL.aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekk.kkkyiatqgPladtvndfWelvye

QECSVVVQCHGLVEDGVAVGTRYWPTRTiwhqMPvmTTHGpkktrkrtirlnDYKIKLVHEAELDHAIYSRIKLWKGAlGPRTLTHVWMLSTGSKREPQH
.. | .|   .|||.|     .|||.       |  . .|            . ...||.. ||.. .  .. | |   . ...|.   |.   .  |. 
nktstivmltelveggktkCeeYWPdad....kp..knyG............svtvtlveskeledfvlrklllekkk.teleitqyqylaWpdhgvPes

ARTWNTVVRDVAGMRTGS-APVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAW
..    ..| |    .    |..|||  |. |  .|.||| |  .. .. . ||.|||..||. | | .. |.|| |.. .  
kapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
0039614 (Phosphotyrosine protein) phosphatases II 702-983 1.8e-47 157.6 In-house 27-288 (297) alignment 
Range on Protein: 702-983
Range on HMM: 27-288/297.0
SSRDPTMLQSEYESIPPNAASvDELPSG--VESRNRSPSVLPNIHSRVYLSVDMSSdtALRDEYINANYMRGLGGVDRRFILTQAPSPTTCEDFWHMVWD
   ..|.|. |.|... .  .  .        ..||....||. ||||.|.. ...   | . ||||.|. |   ..|.||.||.|.| |.||||.|||.
kansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgv..dldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

QECSVVVQCHGLVEDGVaVGTRYWPTRtiwhqmpvmtthgpkkTRkrtiRLNDYKIKLVHEAELDHAIYSRIKLWKgALGPRTLTHVWMLSTGSKREPQH
| ..|.|    |||.|.    .|||..                .     . .|....|. . .||. ..  .....    .||.||.. ..      |..
qgvtvivmLtklvelgr.kcaqywpee................gg....tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvpps

ARTWNTVVRDVAGMRT---GSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTF
...   ... |   .    .. ||.|||  |. | ..|.|....  ||   |. ||| .|..||. |. .. ...|||||. |.  .
lellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
0051299 (Phosphotyrosine protein) phosphatases II 703-983 1.5e-52 174.2 In-house 19-285 (288) alignment 
Range on Protein: 703-983
Range on HMM: 19-285/288.0
SRDPTMLQSEYESIPPNAASVD---ELPSGVESRNRSPSVLPNIHSRVYLSVDMSsdtALRDEYINANYMRGlGGVDRRFILTQAPSPTTCEDFWHMVWD
 ...|.|. |.| .... ....    |     ..||....||. ||||.|||  .      . ||||.|..|    .|.||.||.| |.|.||||.|||.
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg...vegsdYinAsyidg.ynlkrkfIatqgPlpntvedFWrmvwe

QECSVVVQCHGLVEDGVAVGTRYWPTrtiwH----QmpvmtthgpkktrkrtirlNDYKIKLVHEAELDHAIYSRIKLWK-----GALGPRTLTHVWMLS
|...|.|   .|||.|.    .|||.    .                        .|....|..| .||. ..  ... .     |   .|| || ....
qnvrvIvmltklvelgrekcaqYwpl....ggslty...................gditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytn

TGSKREPQHARTWNTVVRDVAGM-RTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTF
      |.... . . .|.|  . . |. ||||||  |. | ..|.|||.| .|| ..|. |||..|..||. |  .....|||||.. |.. .
wpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0047943 (Phosphotyrosine protein) phosphatases II 703-981 3.2e-48 159.9 In-house 8-269 (273) alignment 
Range on Protein: 703-981
Range on HMM: 8-269/273.0
SRDPTMLQSEYESIPPNAASVD---ELPSGVESRNRSPSVLPNIHSRVYLsvdmssdTALRDEYINANYMRGlGGVDRRFILTQAPSPTTCEDFWHMVWD
. ..|.|. |.| ....  ...    |     ..||....||. ||||.|       .   . ||||.|..|   . |.||.||.| | |.||||.|||.
llgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.......gdggsdyinAsyvdg.ynlkrkfiatqgPlpntvedfwrmvwe

QECSVVVQCHGLVEDGVAVGTRYWPTRtiwhqmpvmtthgpkkTRKRTIRLNDYKIKLVHEAELDHAIYSRIKLWK-GALGPRTLTHVWMLSTGSKREPQ
| ..|.|    |||.|     .|||.                   . ... ......|. | . |. .   ..|.. |   .|| ||.....      |.
qnvrviVmLtelvelgrekcaqYwple................ggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvpp

HARTWNTVVRDVAGMRT---GSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAW
.     . ...|  ..    .. ||||||  |. | ..|.|||.|  ||.  |. ||| .|..||. |  .. ..||||||. |. 
slesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall
0036941 (Phosphotyrosine protein) phosphatases II 704-987 1.4e-47 157.8 In-house 10-280 (297) alignment 
Range on Protein: 704-987
Range on HMM: 10-280/297.0
RDPTMLQSEYESIPPNAASVD---ELPSGVESRNRSPSVLPNIHSRVYLsvdmssdTALRDEYINANYMRGLgGVDRRFILTQAPSPTTCEDFWHMVWDQ
 ....|..|.|...|. .. .    |  .  ..||....||. |.||.|       .   . ||||.|. |  ...|.||.||.| |.|.||||.|||.|
lflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.......ddegsdYinAsyvdgy.dlkrkfIatqgPlpntvedFWrmvweq

ECSVVVQCHGLVEDGVAVGTRYWPtrtiwhqmpvmT-------ThgpkktrkrtirlNDYKIKLVHEAE--LDHAIYSRIKLWK-GALGPRTLTHVWMLS
 ..|.|    |||.|     .|||           .                     .|....|... .  ||. ..  ..... |   .||.|| ....
nvtvIvmltelvelgrekcaqywp...........leegeslty.............gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytg

TGSKREPQHARTWNTVVRDVAGMRT---GSAPVVVHCPLGIERGAVFVALDILQMQLI---QQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFA
      |.....    .. |  ..    .. ||.|||  |. | ..|.|.|.. .||     .|. |.| .|..||. |  .. .|||||||. |   . 
wpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

RTH
...
kkk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 705-985 1.2e-52 173.7 In-house 3-269 (274) alignment 
Range on Protein: 705-985
Range on HMM: 3-269/274.0
DPTMLQSEYESIPPNAASVDELPSGVESRNRSPSVLPNIHSRVYLSVDMSSDTALrdEYINANYMRGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSV
... |..|. ..| |    ..  .| ...||  ..||| .||| |. . |.|  .  .||||||..| ..... .. || | |.| .|||.|.. .|..|
sfkdlekeflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededs..syinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqv

VVQCHGLVEDGVAVGTRYWPtrtiwhqmpvmtthgpkK--TRKRTIRLNDYKIKLVHEAELDHAIYSRIKLWKGALgPRTLTHVWMLSTGSKREPQHART
.|    | |   .  ..|.|                 .    . . | .| .|| ..  | ..    .. | .    .|...| |  .   .. |..|.|
ivmltklkeaneqkCavyfP.................daedyeiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddant

WNTVVRDVAGMRTG----SAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFAR
   .|..|   |.      |||||||  || |  .|.| .|   || .... |||..||.||.|||  ... |||...| |   ...
lldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_PTPRD_pd Subfamily PTPRD 705-987 1.4e-42 141.1 In-house 21-284 (564) alignment 
Range on Protein: 705-987
Range on HMM: 21-284/564.0
DPTMLQSEYESIPPNAASVDELPSG--VESRNRSPSVLPNIHSRVYLSVDMSSdtaLRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQEC
. . ...||..| ..  .  |  .     ..||   ...  |||| ||           .||||... |    .. .| ||.| ..|.|||| |||.|..
sdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegd...egsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqns

SVVVQCHGLVEDGVAVGTRYWPTR-TIWHQMPVMTTHgpKKTRKRTIRLNDYKIKLVHeaeldhaiysriklwkgALGPRTLTHVWMLSTGSKREPQHAR
|..|    |.| |     .|||.. |  ..  . | .  ..... .. . . |.|  .                     |. ..    |  ..  |..|.
stiVmltkleEkgkvkchkYWPekgtetygeltVtle..eeeeladyeirtfklkkkk.................ssesreVrqFhFtsWPdhgvpesat

TWNTVVRDVAGMR-TGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTH
.  ...|.|  .. ... |.||||  |..|  .|...|..  .. ...| |. ..| .||..|   . . ||| |.| |   .    
slLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 705-980 1.5e-31 104.7 In-house 20-279 (305) alignment 
Range on Protein: 705-980
Range on HMM: 20-279/305.0
DPTMLQSEYESIPPNAASVD-ELPSGVESRNRSPSVLPNIHSRVYLSVDMSSDtalRDEYINANYMRGLGGVDrRFILTQAPSPTTCEDFWHMVWDQECS
. . |. .|.|.. .  |.| .  .  ...||. .. .  ..|. |. . | |     .||||.|. |  . . ..|..|.| ..| .|||.....   |
sdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekesld...dsdyinasyvdgykrkk.kyivaqgPlkntvadfWrliveekvs

VVVQCHGLVEDGVAVGTRYWPTRTiwhqmpvmtthgpkkTRkrTIRLNDYKIKLVHEAELDHAIYSRIKLWK--GALGPRTLTHVWMLSTGSKREPQHAR
..|.  .|||.|     .|||...               |.  . ........|  |..    |  ..|. .  .    ||...  . .   .  || | 
tivmltklveggkdkCrqYWpesk...............te..kkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfat

TWNTVVRDVAGMRTGS--APVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
.  .....|   .  .   |..|||  |. |  ||.|.||   .| . .. || . . |||. |   ...|.|| ||| | 
sllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdal
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 706-982 1.1e-38 128.1 In-house 19-278 (318) alignment 
Range on Protein: 706-982
Range on HMM: 19-278/318.0
PTMLQSEYESIPPNAASVDELPS---GVESRNRSPSVLPNIHSRVYLSVDMSSdtaLRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQEC
 ..|..||| . .. ..| .| |     . .||   .|.  |.|| |.   ..      .||||||. |    .. .| .||| | |.|||| |||.|..
elllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlege...egsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvWeqns

SVVVQCHGLVEDGVAVGTRYWPTRTiwhqmpvmtthgpkktrkrTIRLNDYKIKLVHEAELDHAIYSRIKLWK-GALGPRTLTHVWMLSTGSKREPQHAR
.|.|    ..| | |   |||| .                    .. ... ...| .| ||.. .  ..|. . .    |.     . |   .  |... 
avivmltqeeergkakvhryWPskg...................srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesga

TWNTVVRDVAGMR--TGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWT
.   .||.|  .   .|  |.||||  |. |  ||.|.|||  .. .... ||..|| |||. | | .   .|| |.. .   
slldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlle
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 706-989 3.3e-35 116.7 In-house 22-288 (319) alignment 
Range on Protein: 706-989
Range on HMM: 22-288/319.0
PTMLQSEYESIPPN-AASVDE-LPSGVESRNRSPSVLPNIHSRVYLSvdmSSDTALRDEYINANYMRGLGGvDRRFILTQAPSPTTCEDFWHMVWDQECS
 |.|. |.. .    . ..|.      ...|| . .|.  ..|| ||   . |     .||||... |     ..|| ||||  .| |||| |||..|.|
etllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvls...eldgvegsdyinasfidgyqe.rekfiatqaPlentiedfWrmvWeeess

VVVQCHGLVEDGVAVGTRYWPTRTIWHQMPVMTTHGPKKtrkrtiRLNDYKIKLVHEAELDHAIYSriklwkgalgpRTLTHVWMLSTGSKREPQHARTW
.||   .||| .     .|||. ....   .. |   ..      .|.|| |. ..  ..   . .           |...|   ..   .  |..|.. 
ivvmltklveklkvklkkywpeenfeeyGrlivtleeee......eledyiirklklnkkssevet...........RevkhfqyteWpdhdvPekatsl

NTVVRDVAGMRT--GSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTHEN
  ......  |    | |.||||  |. |   |..||.   .. ..|. ||  || .||  | . ..  |||.|.. |   .. . . 
ldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt
subfamily_PTPN14_pd Subfamily PTPN14 707-980 1.2e-29 98.2 In-house 23-292 (300) alignment 
Range on Protein: 707-980
Range on HMM: 23-292/300.0
TMLQSEYESIPPNAAS----VDELPSGvESRNRSPSVLPNIHSRVYLSVdmSSDTalRDEYINANYMR-GLGGVDRRFILTQAPSPTTCEDFWHMVWDQE
...  ||| ||.. .     . .||   ...|| . |||  ..|| ||   . ..  ...||||  ..  .|| .| .| .|.| ..|..|||.|||.|.
gkvfteyeripkkredallstaklpen.aeknrfkdvlPyednrvelsp..tken..stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqg

CSVVVQCHGLVEDGVAVGTRYWPTRT------IWHQMPVMTTHGPKKTRKRTIRLndyKIKLVHEAELDHAIYSRIKLWKGALGPRTLTHVwmLSTGskR
 ...|.     |||     .|.|  .       . .  |.|    . ..  |. |   |.| .   |    .. . . |     |. ...   ||    .
vqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittgl...klkhlpskeertvwhlqytDWpdhgvPeDvkgf..lsyL..e

EPQHARTWNTVVRDVagmRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
| |  |   .  ..    .  . ||.|||  |. |  | .  |.|   | .. . |.  .. .||. | | ...| ||.|.. . 
evqsvrrktnseves...keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 709-985 2.2e-36 120.7 In-house 36-291 (298) alignment 
Range on Protein: 709-985
Range on HMM: 36-291/298.0
LQSEYESIPPNAASVDELPSgVESRNRSPSVLPNIHSRVYLSVDMSSDtalRDEYINANYMRGLGGVDrRFILTQAPSPTTCEDFWHMVWDQECSVVVQC
|.|  ..|. .  .| . |.  ...|| .....  .||| |. . . .     .|||| .. .  | .  ||.|||| ..| ||||.||.... ...|  
lnsvsseieeeekevarkpe.nkkkNRyadiialdssRvvLekedade...esdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVml

HGLVEDGVAVGTRYWPT--RTIWHQMPVmtthgpkktrkrtirlndykiKLVHEAELDHAIYSRIKLWKG-ALGPRTLTHVWMLSTGSKREPQHARTWNT
. |.| .    ..|||.   . . .. |                     .| .. |    |  ..|. |    . |.. .. . |  .| .|..|..  .
tnleeldktkyhkywPdegketygeitv.....................sllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvld

VVRDVAGMR--TGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFAR
..|.|  ..  .| .||.|.|  |..|   |.|.| .  .. .. . ||. .|  ||..|   ... ||| |.. |   .  
llrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 709-980 2.7e-33 110.3 In-house 17-272 (281) alignment 
Range on Protein: 709-980
Range on HMM: 17-272/281.0
LQSEYESIPP---NAASVDELPSGVESRNRSPSVLPNIHSRVYLSVDmssDTALRDEYINANYMRGLGGvDRRFILTQAPSPTTCEDFWHMVWDQECSVV
...|||..     . ...         .||   .    ..|| .. .   ...   .|||||.. |. | ....| ||.| |.....||.|||.|. |..
fieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpn...eenkntDYinanfvpgykg.ekeyiatqgPvPaslvafWqmvweqkvsai

VQCHGLVEDGVAVGTRYWPTRTiwHqmpvmtthgpkktrkrTIRLNDYKIKLVHEAELDHAIYSRIKLWKGALGPRTLTHVWMLSTGSKREPQHARTWNT
|     .| |     ||||  .  .                .... |...| ..|.|  . |  ..|| .    .|.....  ..   .  |. ..    
vmvtreieagklkChrYWPddn..s................elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkelle

VVRDV--AGMRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQ-GTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
  ..|  .  .   ||.|.||  |. |  ...||| |  .. ..  ..||  .| .||..| | . .. ||.|.. | 
frkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykav
subfamily_PTPRK_pd Subfamily PTPRK 709-980 3.3e-33 109.8 In-house 24-273 (314) alignment 
Range on Protein: 709-980
Range on HMM: 24-273/314.0
LQSEYESIPPNAASVDElpSGVESRNRSPSVLPNIHSRVYLSVdMSSDTalRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQC
.. ||||..    .  .     ...|||  .|.  .||| | . .  |.    .||||... .     . || || | . | .||| .|.|..|. .|  
fkeeyeslfegwdaakk..denreknrsgdilaydrsrvflit.idgdp..ssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvydencasivml

HGLVEDGVAVGTRYWPTRTIW-HQMPV--MTTHGPKKTRKRTIRLNDykiklvheaeldhaiysrikLWKGALGPRTLTHVWMLSTGSKREPQHARTWNT
  ||| |    ..|||  |    .. |  . |.  ..  .|. |..                     | .|  . |.. ..  |.  .   |..|..  .
telvevgrvkClkyWPedtevygdikvelvetellaelvvrifrvek....................largqeeirevrqfqflgWpdhdvPvsatgllk

VVRDVAGMRT-GSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
.|| |  ..  .  ..||||  |  |  .|.|.||.   . ..|. ||  .| .||. .   ..  |||.|.. ..
lvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_CG42327_pd Subfamily CG42327 710-827 2.9e-21 70.4 In-house 8-122 (319) alignment 
Range on Protein: 710-827
Range on HMM: 8-122/319.0
QSEYESIPPNAASVDELPSGVESRNRSPSVLPNIHSRVYLSVDMSSDtalRDEYINANYMRGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCH
  |.. .|   |. ||.| . . ..|   |.|  ..|| |    . |   .|||..|.|.||    .  .| .|..   .  ||| .||.|   |.||  
aeefrdlPqliaradevPvtskdksrvinvvPlPetrvvlqrigddd...kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

GLVEDGVAVGTRYWPTRT
 | | |. | ..|.||. 
dlselGikvcaeylPtke
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 714-987 1.3e-42 140.7 In-house 2-267 (270) alignment 
Range on Protein: 714-987
Range on HMM: 2-267/270.0
ESIPPNAASVDELPSGVESR--NRSPSVLPNIHSRVYLSvDMSSDTalRDEYINANYMRGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGL
. .. ...| ..||. .  .  ||.  .||. ..|| |. ....|   . .||||||.||  | ....| ...| ||| ..|| |.|... . .|   ||
keldkeetsesdlpeaargkklnRyadiLPsPatRvrle.eleeds..ataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgl

VEDGVAVGTRYWPTrtiwhqmpvmtthgpkkTRKRTIRLNDYKIKLVHEAELDHA--IYSRIKLWKGALgPRTLTHVWMLST---GSKREPQHARTWNTV
.|.|     ||||.                  .|....|.| ||| . ..|  .   |  |..| . .   | |.| |. .    |  ||.... . . .
eEkgrkkCerYWpa.................epkekvkledgkikvlalseekeegyiltrlrleekge.errlvHfwyntWpdhgvpreedsslstdql

---VRDVAGMR--TGS-APVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTH
   .|.|  ..  .    |..|||  |..|  ...||||    | ... .|||  . .||.||  ...  |||.||..|  ..|.. 
lkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 715-987 2.4e-23 77.5 In-house 19-269 (283) alignment 
Range on Protein: 715-987
Range on HMM: 19-269/283.0
SIPPNAASVDElPSGVESRNRSPSVLPNIHSRVYLSVDMSsdtalrdEYINANYMR--GLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLV
|.|.  | ..   .  .  ||   ..|    || |  .         .|||| ..        |...| .|.|   |  |||.||.|.. . .|    | 
svpdldadias.adenkrknrnqeivpadqwrvelksesr.......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklq

EDGVAVGTRYWPTRTIWHQMPVMTTHGpKKTRKRTIRLNDYKIKLVheaeldhaiysriklwKGALGPRTLTHVWMLST---GSKREPQHARTWNTVVRD
||     ..||| |      .   |   | | ...       ..                    |     |.|  .      | .        .| |.  
edlrikCsqyWPkrGsedyGeftvtlr.kettsnsfiikelllrvn................ssakstlllahyqvidWleygeqaiinslvkfnkvisl

VagMRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTH
    .   .|.||||  || | |||.|.     ..  .   ||  .|  .|..|   . .|.||...| ..   |   
q..teskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcg
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 717-979 7.2e-30 99.2 In-house 36-283 (325) alignment 
Range on Protein: 717-979
Range on HMM: 36-283/325.0
PPNAASVDELPSGVeSRNRSPSVLPNIHSRVYLSVDmssDTALRDEYINANYMRGLGGVDrRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLvEDGV
 . |  |  .|  . ..|| . |..  .||| |      . .   .||||.|.|   . |  |. .||| ..| .|.| .| | .|||||    | . | 
dgiakkvamkpenk.aknrfknvvaldksrvvletk...kddpssdyinasylrddkkkd.vflaaqaPltatindlWrlvldWrcsvvvvlnel.dlgk

AVGTRYWPTrtiwhQMPVMTTHGPKKTRKRTIR-LNDYKIKLVHeaeldhaiysrIKL-WKG-ALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAG-
   . |||      .|    | |. . . |||  . ||  . ..           .|   || ..  . . .      | .. |    ..  .|  |   
drcavywpk.....emgksktfGglevklrtieeisdyvhrvld...........vkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavser

MRT---GSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAA
...   .|.|..|||  |. |  ||..|  .  ..|..   |..| | .||.||   ... .|| ... |
vtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyea
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 718-978 1.4e-17 58.7 In-house 30-271 (307) alignment 
Range on Protein: 718-978
Range on HMM: 30-271/307.0
PNAASVDELPSGVeSRNRSPSVLPNIHSRVYLSVDmssdtALRDEYINANYMrGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVA
|.. .|. . .    .||   |    ..|. . .|      |  .|| |||. |.    ..|| .| |  .|  .|| |. ...   |.    ..| .  
pegvtveafsant.dknryqdvkcqdkgrivvkfd.....glasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielaki

VGTRYWPTRTiwHQMPVMTthgpkkTRKRTIRLNDYKIKLVHEAElDHAIYSRIKLWKgALGPRTLTHVWMLSTGSKREPQHARtwnTVVRDVAGMRTGS
   .|||      |  |..       . .|| ...  .| .   | |    . .|.   | . ||..|.       .  ||      | .  .  .|   
kceqywplee..gqklvfg......eapntisvanlgakklapde.dlinvttlkvdw.aqksrtiqhlqwenwpdrgvpqinl...tainlleavrydt

APVVVHCPLGIERGAVFVALDILQMQLIQQG-TADVLGTVCQLRQDRGLCINSLEQYRFLHA
 ||||||  |. |    ||. ..| ..|.     |.   | .||..|  .|..  || .|| 
npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhr
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 718-978 9.6e-13 42.8 In-house 29-265 (288) alignment 
Range on Protein: 718-978
Range on HMM: 29-265/288.0
PNAASVDELPSGVES--RNRSPSVLPNIHSRVYLSvdmsSDTalrDEYINANYMRgLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDG
|| ||.|   | ...  |.|   .     .|| ||     |.   | ||.|| .   .  .||.| .|||  .| | .|.|. ...   .|    |.| |
pneasidiidsfianptrdryenlprcditrvkls....ddp...dfyiaanvvs.sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekG

VAVGTRYWPTRtIWHQMPVMTThgpkktrkrtirLNDYKIKLvheAELDHAIY-SRIKLWKGALGPRTLTHVWMLSTGSKREPQharTWNTVVRDVAGMR
      |.|.. . ... .                .. | |    |..|. .  | ..  |    .  . .. .|    .  |.    . . .| .  ..
keksaeyfPsk.lGekarigrl............ctvvkkkr...adidklvkvsllriskegeekvivkilhlleWdddgvPe...nylsplrllevlk

TGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHA
.   |.|||.  |. | . ..   |   .|  .    .   . .||..|  .|..  || ..| 
slqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhr
subfamily_PTPRN_pd Subfamily PTPRN 719-826 1.1e-16 55.4 In-house 46-149 (297) alignment 
Range on Protein: 719-826
Range on HMM: 46-149/297.0
NAASVDELPsGVESRNRSPSVLPNIHSRVYLSVDMSSDtalRDEYINANYMRGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAV
....| . .  . ..||| .|||  |||| |. . |..   ...||||  .         .| ||.| ..|  ||| |||.| . |.|.   | |.||  
stkevakae.knvkknrskavlpydhsrvklkeeasae...ksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkq

GTRYWPTR
 .||||  
ckrywpde
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 722-827 8.5e-16 52.6 In-house 36-154 (350) alignment 
Range on Protein: 722-827
Range on HMM: 36-154/350.0
SVD-ELPSGVE--SRNRSPSVLPNIHSRVYLS-----VDMSSDTALRDEYINANYMRGL-G----GVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQC
| | .| .|||  ..||   .||  |||| |       |    .   ..||||||..          | ..| |||| | | .||....   .  |..  
snDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsl

HGLVEDGVAVGTRYWPTRT
  .|| ..    |||.  .
tsdvelnlekcyrYWqegs
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 724-984 3.9e-17 57.1 In-house 27-259 (267) alignment 
Range on Protein: 724-984
Range on HMM: 27-259/267.0
DELPSGVESRNRSPSVLPNIHSRVYLSVDMSSdtalrdeYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAvgtRYW
  ... .. |||   .||  ..|| |.            |||| |. |     . ||.|| |   |  ||. .. ||...|.|  .   .| .    ..|
qsiaeknqernrlddnlpyddtrvilrtkeee.......yinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltkvftdnir...lfw

PTR-TIWHQMPVM-TTHGPKKTRkrtirlNDYKIKLVhEAELDHAIYSRIKLWkgalgprtLTHVWMLSTGSKrePQHARTWNTVVRDvaGMRTGSAPVV
| .    ..   .   |  .|        |||.|  . | ..       . |.          . | . |  |  |     .  . ..   .  |. |.|
PPkmgqakkyqdltvehslekee......ndyqiitl.elkfknesahnvtly........yykkwnintnnk..pylkplfgilakn..qlengnrPlv

VHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFA
|.|  |. |   |. .|    .. ..|..|.   . ..|. |   ....|.| ..|     .|
vacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 724-824 3.7e-13 43.5 In-house 40-154 (349) alignment 
Range on Protein: 724-824
Range on HMM: 40-154/349.0
DELPSGVES--RNRSPSVLPNIHSRVYLSVDM-----------SSDTALRDEYINANYMRG-LGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCH
 .| .|||.  .||   .||  |||| |   .            ||..  |.||||||..     |....| ||||.|.| .||....  ..  .|.   
vilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLn

GLVEDGVAVGTRYWP
   | ..    .|| 
ddkelslekcdiywq
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 724-824 4e-08 27.2 In-house 90-179 (244) alignment 
Range on Protein: 724-824
Range on HMM: 90-179/244.0
DELPSGVESRNRSPSVLPNIHSRVYLSvdmssDTALRDEYINANYMRGLGGVdRRFILTQAPSPTTCEDFWHMVWDQECSVVVQcHGLVEDGvavgTRYW
| .      .||  . ||   .|| ||       .. . |||| ..  ||     .|||| |   |  |||.|. ..   |.|   | ||.       ||
dafnpnnswknregaglpfdfnrvpls.....kgsmgntyinasfvgclgrt.aeyiltqhpladtsmdfwkmmlerhvnvlvv.lgsveee....deyw

P
|
p
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 725-808 7.9e-08 26.2 In-house 33-116 (347) alignment 
Range on Protein: 725-808
Range on HMM: 33-116/347.0
ELPSGVeSRNRSPSVLPNIHSRVYLSVDMS--SDTALRDEYINANYMRgLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQC
|    . |.|||  |  .  .|| || . |  | .   . |||| ... .   .. .|||| | | |  |||.||     . ||  
eweksl.sknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_PTPRB_pd Subfamily PTPRB 726-988 4.1e-43 142.5 In-house 47-289 (293) alignment 
Range on Protein: 726-988
Range on HMM: 47-289/293.0
LPSGVESRNRSPSVLPNIHSRVYLSvdmSSDTALRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPT
  .  ...||   .||  |||| |.   . ..   ..||||||..|.    | || || | |.| .|||.|||....|..|    ||| |     .|||.
elavnraknrytnilpydhsrvkLa...alkdesgsDYinanyipgyn.sprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPa

RtiwhqmpvmtthgpkktrKRTIRLNDYKIKLVHEAELDHAIYSRIKLWKgALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMR---TGSAPVVV
                   ....   | |..||.| ||.. .   .|. | .   |....   .|      |....|  . || |  .    . ..|.||
d..................eepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivv

HCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTHE
||  |. |  .|.||| |  .. .. . |..|.|..||..| | . . .|| |.| .  .. |..|
hCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 728-984 2.2e-26 87.4 In-house 44-283 (290) alignment 
Range on Protein: 728-984
Range on HMM: 44-283/290.0
SGVESRNRSPSVLPNIHSRVYLSvDMSSDTALRDEYINANYMRGLGGvDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRT
|  . .||.  ....   |. |  ..|..    .||||| |. |    ....|.||.| . |  |||...|.......|     .|.|  .   |||.. 
ssnkllnRfanivvyddnritLr.pisghkDCtneyinAcyikgyke.kkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsd

IWHQMPVMTTHgpkktrkrtirlndykiklVHEAELDHAIYSRIKLWKGAL--GPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAG--MRTGSAPVVVH
  .  ..  .                    ..| .|.. |  .... .      ....|.  . .  |. . ..  |  .|.. .     ..|  ..|||
tkaygefsikl...................lneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvH

CPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFA
|  .. | |||.|...   .  ..|  ||.  . ..|. .   ... .||....    |  
CSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
DSPc_SM00195 730-982 9.4e-48 158.2 In-house 27-260 (263) alignment 
Range on Protein: 730-982
Range on HMM: 27-260/263.0
VeSRNRSPSVLPNIHSRVYLSVDMSSdtaLRDEYINANYMRGLgGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTiw
. |.||.  .||. |.|| |. . ..     ..||||||..|    ....|.||.| |.|.||||.|||.......|     .|.|    .||||     
k.sknRyknilpydhtrVklkkeekk...egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees..

hqmpvmtthgpkktrKRTIRLNDYKIKLVHEAELD-HAIYSRIKLWKGA-LGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRT-GSAPVVVHCPL
               ... . .....|||.. . . . |   ..| | .   .|..|.... .   .  |....    ..| |   .   |.|.||||  
...............ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsa

GIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWT
|..| ..||..||.  .| .. . |.  .|..||. |  ....||||.|.. |.  
GvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 730-982 9.4e-48 158.2 In-house 27-260 (263) alignment 
Range on Protein: 730-982
Range on HMM: 27-260/263.0
VeSRNRSPSVLPNIHSRVYLSVDMSSdtaLRDEYINANYMRGLgGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTiw
. |.||.  .||. |.|| |. . ..     ..||||||..|    ....|.||.| |.|.||||.|||.......|     .|.|    .||||     
k.sknRyknilpydhtrVklkkeekk...egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees..

hqmpvmtthgpkktrKRTIRLNDYKIKLVHEAELD-HAIYSRIKLWKGA-LGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRT-GSAPVVVHCPL
               ... . .....|||.. . . . |   ..| | .   .|..|.... .   .  |....    ..| |   .   |.|.||||  
...............ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsa

GIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWT
|..| ..||..||.  .| .. . |.  .|..||. |  ....||||.|.. |.  
GvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 730-983 7.3e-23 76.0 In-house 47-277 (287) alignment 
Range on Protein: 730-983
Range on HMM: 47-277/287.0
VESRNRSPSVLPNIHSRVYLSvdmssdtALRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTrtiw
 . .||.  .|.    || |          ...|||| .. |    ...||....|   |  .||....|.. ...|    . |.   |  .|||.    
nkdknRltqilvpdnyrvllk.......gehpdyinavfidgyk.ekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpe....

hqmpvmtthgpkktrKRTIRLNDYKIKLVHEAELDHAIYSRIKLWKGA--LGPRTLTHVWMLSTGSKREPQHARTWNTVVRDV--AGMRTGSAPVVVHCP
               .... | .|.|.|..|   .. |  .... .      .....   . .  |... .. .|   |. .   .  . | ...|||| 
...............eksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCs

LGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTF
 .. | |.|.| ..   .  ..|. ||.  . . |. .   .   |||.|.  .  ..
dtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivley
subfamily_ptpA1_pd Subfamily ptpA1 730-836 4.9e-16 53.5 In-house 47-148 (418) alignment 
Range on Protein: 730-836
Range on HMM: 47-148/418.0
VESRNRSPSVLPNIHSRVYLSVDMSSDtalRDEYINANYMRGlgGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIW
  |.||   .||  |.|| |      .     .||||||. |     ..|| || | | |  |||.|||.. | ..|      |.      |||| .   
ntsknrytnilpvnhtrvqlkkiqdke...gsdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigg

HQMPVMT
 |. .  
eqfsiyg
0046845 (Phosphotyrosine protein) phosphatases II 731-987 9.7e-53 174.7 In-house 29-277 (284) alignment 
Range on Protein: 731-987
Range on HMM: 29-277/284.0
ESRNRSPSVLPNIHSRVYLSVDMSSdtALRDEYINANYMRGLG----GVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTR
 |.||....||. ||||.|..  ..     ..||||.|..| .     . ..||.||.| |.|.||||.|||.|...|.|   .|||.|.    .|||. 
lsknRykdilpydhsRVklksldgd..ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple

TIWHQMpvmtthgpkktrkrtirlNDYKIKLVHEAELDHAIYSRIKLWKG--ALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRTG---SAPVV
  . ..                  .|....|..| . |. .. ...| .      .||.|| ...|      |....   . .|.|  ...    . |.|
gevlty..................gdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpiv

VHCPLGIERGAVFVALDILQMQLIQQG---TADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTH
|||  |. | ..|.|||.|  ||...|   . |||..|..||. |  ....||||||.. |.. .....
VHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
0045098 (Phosphotyrosine protein) phosphatases II 731-983 9.4e-46 151.8 In-house 34-271 (278) alignment 
Range on Protein: 731-983
Range on HMM: 34-271/278.0
ESRNRSPSVLPNIHSRVYlsvdmssdtalrdEYINANYMRGLggvDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIWH
 ..|| ...||. ||||.             .||||.|..|    ...||.||.| |.|..|||.|.|.. ..|.| . .|||.|.    .||| .  . 
ldknRykdilpydhsrVk.............dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslt

QmpvmtthgpkktrkrtirlNDYKIKLVHEAELDHAIYSRIKLWK-----GALGPRTLTHVWMLSTGSKREPQHA--RTWNTVVRDVAGMRT--------
                    .|....|. | .||. .. .....        | .|..||...|.      | .   . .  ... .   .         
y...................gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasllls

------GSAPVVVHCPLGIERGAVFVALDILQMQLiqQGTADVLGTVCQLRQDRGL-CINSLEQYRFLHAAAWTF
      .. ||.|||  |. | ...||....  .|  .|. |.| .|..||. |.  .. .|||||||. ..  .
slllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllel
0045450 (Phosphotyrosine protein) phosphatases II 731-981 2.8e-45 150.7 In-house 56-301 (307) alignment 
Range on Protein: 731-981
Range on HMM: 56-301/307.0
ESRNRSPSVLPNIHSRVYLSVDMSSdtALRDEYINANYM--------RGLGGvDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRY
 ..||....||. |.||.||.  .|     . ||||.|.         |    .|.||.||.| | |.||||.|.|.| ..|.| . .|||.|     .|
kdknrykdilpydhtRVklssldgs..ledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqy

WPTRTIWHQMPvmtthgpkktrkrtirlnDYKIKLVHEAELDHAIYSRIKLWK--GALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRT---GS
||.   . .                    .....|. | .||. .. .....   |   .||.|| ....      |..  .    .. |  ..    ..
wPdegeeltyg..................nftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkg

APVVVHCPLGIERGAVFVALDILQMQLIQQGT---ADVLGTVCQLRQDRGLCINSLEQYRFLHAAAW
 ||.|||  |. | ..|.|....  || ..||    |.| .|..||. |. .. ..||||||. |. 
gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
subfamily_PTPN23_pd Subfamily PTPN23 731-991 7.9e-33 108.5 In-house 44-287 (288) alignment 
Range on Protein: 731-991
Range on HMM: 44-287/288.0
ESRNRSPSVLPNIHSRVYLSvdmssdtALRDEYINANYMRGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTiwh
 ..|||  .||  |.|| |          .|.|||| ....|  .   || |||| ..|  ||| ||..|  ||.|  .   | |     ||||...   
seknrsrdilPyDhnRvklr.......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedk...

qmPVMTTHGPkktrkrtirlndYKIKLVHEAELDHAIYSRIKLW-KGALGPRTLTHVWMLSTGSKREPQ---HARTWNTVVRD--VAGMRTGSAPVVVHC
     ...|.            ... | .. |... .   .||  ..|   ....|. . |  .   |.   .   .  .|..   |  |   .|.||||
..getvkfgd............lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhC

PLGIERGAVFVA-LDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTHENQL
  |..|  ||     ...    ..| .|..  | .||..|   ..  ||..|.  |  . ||   .. 
saGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvldkr
subfamily_PTPN6_pd Subfamily PTPN6 731-988 1.3e-29 98.2 In-house 55-301 (306) alignment 
Range on Protein: 731-988
Range on HMM: 55-301/306.0
ESRNRSPSVLPNIHSRVYLSvdmsSDTALRDEYINANYMR-GLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIW
...||  ..||  |.|| |.    ..    ..||||||..  . | |...| ||   .|| .|||.|||.... |.|     || |    .||||. .  
keknryknilPfDhtrvilk....epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeek

HQMPVMTTHGPKKTRKRTIRLNDYKIKLVHEAELDHAIY-SRIKLWKGALGPRTLTHVWMLSTGSKREPQHARtwntvvrdvagmRTGSAPVVVHCPLGI
... ... .  .......  | . ... .....  . ..  . | |  .  |.   .|  . .  .|. .. .            .. . |.||||  ||
eeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeele............eaeagpivvhCsaGi

ERGAVFVALDILQMQLIQQGT---ADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTHE
 |   |. .|||  .. ..|.    |.  .| ..|. |   ..  .||.|.. |  .. .|..
GRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_CG7180_pd Subfamily CG7180 731-977 1.7e-26 87.6 In-house 43-283 (296) alignment 
Range on Protein: 731-977
Range on HMM: 43-283/296.0
ESRNRSPSVLPNIHSRVYLSvdmSSDTALRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVaVGTRYWPTRTI--
  .|| . |.|  . ||.|.   . |   ...|||| |. ..   .. .| |.||   | ..|| .|.|.|.| ||      .        ||| ..   
reknrdvkvvPyDynRvvLe...kldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeq

WHQMPV--MTTHGPKKTRKRTIRLNDYkIKLVHEAELDHAIYSRIKLwKGALGPRTLTHVWMLSTGS-KREPQHARTWNTVVrdvaGMRTGSAPVVVHCP
. .. |  ....   . ..||..|.   |  . | | .  .  || . .  |    | .   ||| .     . .|.|   |      .   .||||...
ygeifveiveekqyanlkirtfkltkk.ivalteqekqvkaetRivk.lfqlteWeledkvPlstnalielrrrvrlwrekv....dedpeegPvvvvss

LGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLH
 |  |  |..|.|.   ......  || . | .||..|   ... |.|... 
dGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiY
subfamily_PTPN1_pd Subfamily PTPN1 731-979 5.1e-26 86.0 In-house 33-266 (290) alignment 
Range on Protein: 731-979
Range on HMM: 33-266/290.0
ESRNRSPSVLPNIHSRVYLSVDMSsdtalrdEYINANYMRgLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIwh
 ..||   | |  |||. |  .         .||||. .  |  ..|..|||| | | |.. ||.|||.|..  ||    .|| .    ..|||.     
rnlnryrdvspydhsrikleradn.......dyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee..

qmpvmtthgpK--------KTRKRTIRLNDYKIKLVHEAELDHaiysriklwKGALGPRTLTHVWMLS---TGSKREPQHARTWNTVVRDVAGMRTGSAP
          .        | . . |. ....   |.  ||.          . .   |...|   ..    |  . |.    .   ||.   . .   |
..........ekellledtklkvkliseerksyytvrllelen.........lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGp

VVVHCPLGIERGAVFVALDILQMQLIQQGT---ADVLGTVCQLRQDRGLCINSLEQYRFLHAA
.|.||  || |   |. .| . ... ...     |.  ....||. |   |   .| || . |
avihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsyla
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 731-987 3.8e-25 83.2 In-house 39-280 (287) alignment 
Range on Protein: 731-987
Range on HMM: 39-280/287.0
ESRNRSPSVLPNIHSRVYLSvdmsSDTALRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRtiwh
 ..||   |||  ..|| ||     .. |  .||||||. .    | .|| .|.| ..|  ||| .|.... ..|.     ||..     .||| |    
vkknryadvlPiddtrvlls....aegelGsdyinanyvasyt.ddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer....

QMPVMTThGP-KKTRKRTIRLNDYKIKLVHEAELDHA---IYSRIKLWKGALGPRTLTHVwmlstGSKREPQHARTWNTVVRDVagmrTGSAPVVVHCPL
..|..   |      ...|.  .| .. .  ..|.     .  ...| .   .  . | |     |  |     .    . ||     ..  |.|||.  
evPmrvG.GysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtav.....glirfvldvkqhielarda....sevGPlvvhddv

GIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTH
|| |  ...|. .|  .| . |  ||  .| .||. |   ...  |.|.|  |  |. .| 
GiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 731-979 9e-24 78.9 In-house 45-272 (315) alignment 
Range on Protein: 731-979
Range on HMM: 45-272/315.0
ESRNRSPSVLPNIHSRVYLSVdmsSDTALRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRtiwh
 ..||   .||  ..|| | |    |    ..|||| |....   |. .| .|.| ... .|||.||.... . .|    . |.      .||| |    
fkknryknilPldsarvklev...iddsPdsdyinasyiksvd.ddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr....

qmpvmtthgpkktRKRTIRLNDYKIKLVHEAELDHAIYSRIKLWKGAlGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGM-RTGSAPVVVHCPLGIE
             .  ....  .|..|.       ..  .. . |.    ||.|   .     |  .... .   ....| .  ..   ...|||  |. 
.............kadsvefGsikvellsleadtdgvarklvtrkse.esrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvG

RGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAA
|  |....|    |. .. . ||. .| .||..|   ... |.| |.. |
rtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiyda
0049772 (Phosphotyrosine protein) phosphatases II 731-985 2.5e-22 75.5 In-house 47-281 (314) alignment 
Range on Protein: 731-985
Range on HMM: 47-281/314.0
ESRNRSPSVLPNIhSRVYLSvDMSSDTalrDEYINANYMRGLggvdRRFILTQAPSPTTCEDF----------WHMV--WDQECSVVVQ-----------
 ..||.. .||   .|| |.  .. ..     ||||.|..|     ..|| ||.|.. |..||          |.||  .|. . ..|            
rdknryldilpad.nrvilp.glpvsg...sdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------CHGLVEDGvavgtRYWPTRTIWHQMpvmtthgpkktrkrtirlndykiklvheaeldhaI-------YsriklwkgalgPRT-LTHVWMl
            .| . |      ... ... .                                            .           .|. ...... 
rLdaAlgKtpllildgng.....neptaadlellk..................................eelydpelf...........erlgikylri.

STGSKREPqHARTWNTVVRDVAGMrTGSAPVVVHCPLGIERGAVFVALDILQMQLiqqGTaDVLGTVCQLRQDRG-----LCINSLEQYRFLHAAAWTFA
 .    .|   . .. ... .        ||.|||  |. | ..||....| ..|   |  ..  .. ..|. |       .|..|||| | . |   . 
pvpDgsap.lledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleyl

R
.
k
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 731-980 6.3e-21 69.2 In-house 46-232 (392) alignment 
Range on Protein: 731-980
Range on HMM: 46-232/392.0
ESRNRSPSVLPNIHSRVYLSVdmsSDTALRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGvavgtrywptrtiwh
  .||   .||   .|| | |    |    ..|.|| |....   .. .| .|.| ... .|||.||.... . ..    | |                 
lkknryknilpydsarvklev...iddipdsdylnasyipsfd.nekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...............

qmpvmtthgpkktrkrtirlndykiklvheaeldhaiysriklwKGAlGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRTG-SAPVVVHCPLGIE
                                            ||    || .   .     |  |.|. .   ....|       . |...||  |. 
............................................kgd.dartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvg

RGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
| .| ...| .  .  .    ||.  | ..|. |   ... ||| |...| 
rtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
0040438 (Phosphotyrosine protein) phosphatases II 732-986 2.7e-47 157.0 In-house 45-278 (317) alignment 
Range on Protein: 732-986
Range on HMM: 45-278/317.0
SRNRSPSVLPNIHSRVYLSVdmsSDTALRDEYINANYMRGlGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTrtiwhq
..||.|..||. ||||.||.    .  | . ||||.|. |     |.||.||.| | |.||||.|||.| ..|.|    |.|.|.    .|||.      
dknrypdilpydhsRVkLsp...lggdldsdYInAsyvdg.pnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl......

M-----PvmtthgpkktrkrtirlnDYKIKLVHEAELDHAIYSRIKLWK-GALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRTG-SAPVVVHC
                         |....|. | ||.. .. ...... |   .||.|| ....      |.. ..    .. |   . . . ||.|||
getltyg..................dftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHC

PLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFART
  |. | ..|.|.... .|| . |. ||  .|..||. |. .. ..||||||. |.  . ..
saGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
Y_phosphatase Protein-tyrosine phosphatase 732-979 1.8e-46 153.9 Pfam-A 3-232 (235) alignment 
Range on Protein: 732-979
Range on HMM: 3-232/235.0
SRNRSPSVLPNIHSRVYLsvdmsSDTAL-RDeYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWP----TR
..||....||  ..|| |     ...    | ||||||..|    ...||.||.| . |.||||.|||.....|.|.   |.| |     .|||    . 
kknRykdilpydktrvkl.....kgsegpsd.YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

TIWHQMPVMTThGPKKTRKRTIRLNDYKIKLVHEAEldhaiysriklwkgalGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMR-TGSAPVVVHCP
.  ... | ..   .|. .  . |.....|   | .                 .|....... .   .  |....    ..|.|   . . |.|||||| 
ltygdikvelk.ekekedekeytlrklelkkkkees................ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCs

LGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAA
 |..| ..||||||| .|| .... ||| .|..||. |  ...||||| ||..|
aGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyka
Y_phosphatase Protein-tyrosine phosphatase 732-979 1.8e-46 153.9 In-house 3-232 (235) alignment 
Range on Protein: 732-979
Range on HMM: 3-232/235.0
SRNRSPSVLPNIHSRVYLsvdmsSDTAL-RDeYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWP----TR
..||....||  ..|| |     ...    | ||||||..|    ...||.||.| . |.||||.|||.....|.|.   |.| |     .|||    . 
kknRykdilpydktrvkl.....kgsegpsd.YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

TIWHQMPVMTThGPKKTRKRTIRLNDYKIKLVHEAEldhaiysriklwkgalGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMR-TGSAPVVVHCP
.  ... | ..   .|. .  . |.....|   | .                 .|....... .   .  |....    ..|.|   . . |.|||||| 
ltygdikvelk.ekekedekeytlrklelkkkkees................ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCs

LGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAA
 |..| ..||||||| .|| .... ||| .|..||. |  ...||||| ||..|
aGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyka
0043336 (Phosphotyrosine protein) phosphatases II 732-981 8.2e-44 145.5 In-house 47-274 (278) alignment 
Range on Protein: 732-981
Range on HMM: 47-274/278.0
SRNRSPSVLPNIHSRVYLSVDmssDTALRDEYINANYMRGlGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPtrtiwhq
..||....||. ||||.||..   .  | . ||||.|. |   | |.||.||.|.| |.||||.|||.. ....|   .|||.|.    .|||       
dknrykdilpydhsrvklsll...ggdldsdYinAsyvdg.ynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.......

mpvmtthgpkktrKRTIRLNDYKIKLVHEAELDHAIYSRIKLWK-GALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRT-GSAPVVVHCPLGIE
             . ... .|....|. | .||. .   ..... |   .|| ||.. |.      | .  .    ...|  ..   . ||.|||  |. 
.............ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvg

RGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAW
| ..|.||..| .||   |. |.. .|..||. |. .. ...|||||. |. 
RTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
0040439 (Phosphotyrosine protein) phosphatases II 732-980 3.9e-41 136.7 In-house 13-242 (249) alignment 
Range on Protein: 732-980
Range on HMM: 13-242/249.0
SRNRSPSVLPNIHSRVYLSVDMSsdtALRDEYINANYMrGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPtrtiwhq
..||.|..||. ||||.||.  .      . ||||.|.  .  . ||||.||.| | |.||||.|.|.. ..|.| .  ||| |     .|||       
dknrypdilpydhsrvklsilpg...lflsdyinAsyi.dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp.......

mpvmtthgpkkTrKRTIRLNDYKIKLVHEAELDHAIYSRIKLWK-GALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRT---GSAPVVVHCPLG
           . . ..  .|....|... ..|. .   ..|.. .   .|| .|.....      |..  .    .. |  ...    . ||.|||  |
...........l.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaG

IERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
. | ..|.|.... .||   .. |.. .|..||. |. .. ..||||||. |.
vgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeal
0042113 (Phosphotyrosine protein) phosphatases II 732-980 9.5e-40 131.9 In-house 11-239 (245) alignment 
Range on Protein: 732-980
Range on HMM: 11-239/245.0
SRNRSPSVLPNIHSRVYLSVdmsSDTALRDEYINANYMrGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTrtiwH-
..||....||. |.||.||.    .. | . ||||.|. ..  . ..||.||.|.| |.||||.|.|.. ....| .  ..|.|     .|||.    . 
dknrysdilpydhtrvklsp...dggdldsdyinasyv.dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl....ge

---QmpvmtthgpkktrkrtirlNDYKIKLVHEAELDHAIYSRIKLWK-GALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRT--GSAPVVVHC
                       .|....|. |  ||. .   ..... |   .|. .|.. |.     .| . ..   ... |   .   .. ||.|||
slty...................gdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHC

PLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
  |. | ..|.|.... .||   .. ..  .| .||. |. .. ...|||||. |.
saGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
0037934 (Phosphotyrosine protein) phosphatases II 732-979 4.3e-37 123.4 In-house 12-237 (243) alignment 
Range on Protein: 732-979
Range on HMM: 12-237/243.0
SRNRSPSVLPNIHSRVYLsvdmsSDtalrDEYINANYMRGLGgvdrRFILTQAPSPTTCED----FWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPtrt
|.|| ...||. ||||.|     ..    . |||||......    |.|.||.| | |.||    ||.|.|.. ..|.| .  ||| |.    .|||   
sknrysdilpydhsrvkl.....eg....sdyinanliyvtp....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...

iwhqmpvmtthgpkktrkRTIRLNDYKIKLVHEAELDHAIYSRIKLWK--GALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAG---------MRTG
                   ... .|....|..| .||. ..  ..|.       .|. .|.. |.      |..       ...|            . .
..................gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllalds

SAPVVVHCPLGIERGAVFVALDILQMQLiqqgTADVLGTVCQLRQDRGL-CINSLEQYRFLHAA
. ||.|||  |. | ....|.... ..|    . |.. .|..||. |.  .. ...|||||. |
ggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyea
subfamily_PTPRG_pd Subfamily PTPRG 732-992 1.1e-36 121.2 In-house 49-295 (563) alignment 
Range on Protein: 732-992
Range on HMM: 49-295/563.0
SRNRSPSVLPNIHSRVYLSVDMSSDTALrdEYINANYMRGLGGvDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIwHQ
 .||  ....  .||| ||     .  |  .||||||. |     . || || |...|..|||.|.|.|. ...|    |||.|     .|||. .   .
rKnRylnivaydrsRvklsplpgkkkkl..DYinAnyidGyqk.skafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdes.et

MPVMTTHGPKKTRKRTIRLNDYKIKLVHEAELDHaiysriklwkgALGPRTLTHVWMLSTGSKREPQHAR-TWNTVVRDVAGMRTGSAPVVVHCPLGIER
. ...    .. .. .   .  .|| ..  . ..           .   .. ..  . .   .  |.|.    . |... |  ..   |.||||  |. |
ygalqvtlieeevlalytvrtlviknlklkkkkq...........cdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgr

GAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTHENQLG
  ....|| |  |. |. . .|.|.. ..|  |   ... ||| ||| |     ...|..| 
tGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketell
subfamily_PTPN9_pd Subfamily PTPN9 732-987 9.8e-36 118.3 In-house 44-293 (297) alignment 
Range on Protein: 732-987
Range on HMM: 44-293/297.0
SRNRSPSVLPNIHSRVYLSVDMSSDtalRDEYINANYMRGLGGvDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWP-TRTIWH
..||   ||   ..|| |.     .     .|||||.. |     . || || | . |..||| |||.||. |.|    .|| |    ..||| ..   .
eknrytdvlcydetrvvlakvdede...asdyinanfvdGykq.kkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessa

QMPVMTTHGPKKTRKRTIRLNDYKIKLVHEAELDHAIYSRIKLWKGALGPRTLTHVWMLStGSKREPQhARTWNTVVRDVAGmRTGSAPVVVHCPLGIER
.   .. .  .   ..  . . ..|| |.. |  . .. ..  |     |.. . .  .     || | | . ...  . .| ..   |.||||  || |
efgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvl.ekvrekq.alavkelgdewkg.hpsgPPivvhcsaGiGr

GAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTH
   |..|||   .| ..||.||  || .||. |   |   ||| | . |   .| ..
tGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalel
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 732-986 7e-30 99.0 In-house 11-244 (250) alignment 
Range on Protein: 732-986
Range on HMM: 11-244/250.0
SRNRSPSVLPNIHSRVYLSVDMsSDT-AlrdEYINANYMRGLGGVdRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAvGTRYWPTR--TI
 .||   ...  .||| |  .  .|  .   .|||| .. |  .  . || ||.| ..| |||| ||.... ...|    |.| .    ..|||.   ..
eknryadiialdssrvvLekek.gdkes...dyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaek

WHQMPVMTtHgpkktrkRTIRLNDYKIK---LVHEAELDHaiysriklwkgalgpRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGM--RTGSAPVVVH
. .. |   .        .    ||...   | .. . |.               |.. ..  ..   |  |..|..   ....|     ..|.|||.|.
yGdvtvsl.l.......skeefadytkrklklskakkade...............rivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivq

CPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFART
|  |. |   |.|.| .  .| .. . ||   . .||.||   ..||||| |.. ..  .  .
CsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_PTPN13_pd Subfamily PTPN13 732-980 8.9e-30 98.9 In-house 39-265 (273) alignment 
Range on Protein: 732-980
Range on HMM: 39-265/273.0
SRNRSPSVLPNIHSRVYLSVDMSsdtalrdeYINANYMRGLGGVDR-RFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTiwh
..||   |||  ..|| |. . .        ||||....   | |. ..|..| | |.|..||| |||.|...|..     .|.|     |||| ..   
dknryrnvlPydetrvklgdegg........yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesk...

qmpvmtthgpkktRKRTIRLNDYKIKLVHEAELDHAIYSRIKLWKGALG-PRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRTGSAPVVVHCPLGIE
             .|..   | ....|..  .||    ..... . . |  | ..|. . .      |..|    ..|. |. ..| ..|.||||  || 
.............nkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiG

RGAVFVALDILqMQLI-QQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
|  .....|.. ..|| ..   ||  .| .||. |   . . .|| | . |.
rsGtlitidvv.lglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_PTPN12_pd Subfamily PTPN12 732-985 7.3e-29 95.5 In-house 42-278 (290) alignment 
Range on Protein: 732-985
Range on HMM: 42-278/290.0
SRNRSPSVLPNIHSRVYLSVDMSSDtalRDEYINANYMRGLGGvDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTiwhq
 .||   .||  .||| || . ...    ..|||||...|  | . ..| .|.| |.| .|||.|.|... ..||    .|| |     |||| ..    
kknrykDilPydksrvelskieeee...gsdYinanfikgveg.kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeeg....

mpvmtthgpkktrKRTIRLNDYKIKLVHEAELDHAIYSRIKLWKGALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMR-TGSAPVVVHCPLGIER
             ..... ......| .|  .|. .  |    .     |...     .   .  |. | .   ....|  .. . .||.||||  |. |
.............eeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGr

GAVFVALDILQMQLIQQGT---ADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFAR
  . .|.|. ...| .. .    ||   | .||..|   . . |||.... |   . .
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_PTPN3_pd Subfamily PTPN3 732-978 8.7e-29 95.3 In-house 43-269 (280) alignment 
Range on Protein: 732-978
Range on HMM: 43-269/280.0
SRNRSPSVLPNIHSRVYLSvdmSSDTalrdEYINANYMR--GLG-GVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRti
|.||   .||  . || |.   .|.|    .||||||.     . |.  |.| || | ..|..|||.|||.|..|..|    |||.|     .|||.   
sknryrdilpydatrvklk...eset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPet..

whqmpvmtthgpkktrKRTIRLNDYKIKLVHEAELDHAIYSRIKLWKGA-LGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRTG-SAPVVVHCPL
                . .... ....|. .|.|    ..  . | . .    |.....  |.   .  |...  . ..|. |  .|.| . ||||||  
................edeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsa

GIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHA
||.|  |...|..  . . ..    .|  | ..|. |.  ... .||.|.  
GigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCe
0041856 (Phosphotyrosine protein) phosphatases II 732-984 1.6e-25 85.1 In-house 3-171 (182) alignment 
Range on Protein: 732-984
Range on HMM: 3-171/182.0
SRNRSPSVLPNIHSRvylsvdmssdtalRDEYINANYMRGLGGVDRrFILTQAPSPTTCEDFWHMVWDQECSVVVQCHglvedgvavGTRYWPtrtiwhq
..|| . .||. |||                |||||...|    .| ||.||.| . |..||..|.... ....| .          . .|||       
dknrysdilpydhsr.............dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp.......

mpvmtthgpkktrkrtirlN-DykiklvheaeldhaiysriklwkgalgPRTLTHVWMLSTGSKREPQhartWNTVVRDVAGMRTGSAPVVVHCPLGIER
                   .                             .|. .... |.      |     ...... .  ..  . ||.|||  |. |
...................ell...........................erlgiqylylpwpDhgvpd....ldelldfieevleeggpvlVHCsaGvgR

GAVFVALDILQMQliqqgTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFA
 ...||....  .       ..  .|...|. |  .. ...||.||. |.. . 
tgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 732-979 5.1e-25 82.5 In-house 45-271 (515) alignment 
Range on Protein: 732-979
Range on HMM: 45-271/515.0
SRNRSPSVLPNIHSRVYLSVDmssDTALRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRtiwhq
..||   .||   .|| | |    . .   .|.|| |....   |. .| .|.| ... .|||..|.... . ..    | |.     ..||| .     
kknryknilPydsvrvklevi...ndnPhsdyfnasyipsfd.ndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdk.....

mPvmtthgpkktrKRTIRLNDYKIKLVHEAELDHAIYSRIKLWKGALgPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGM-RTGSAPVVVHCPLGIER
 |             ....  .|..||       .|  .... ||    ||.|   .     |  |.|...   ....|       . |...||  |. |
.p...........gdsvkfGsikvelvsleactggikrkltvlkgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGr

GAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAA
  |....|    .  .  . ||. .| ..||.|   .   ||| |.. |
tGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiyga
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 732-980 1.3e-24 82.1 In-house 63-287 (319) alignment 
Range on Protein: 732-980
Range on HMM: 63-287/319.0
SRNRSPSVLPNIHSRVYLSVDMSSDTalrDEYINANYMRGLGGVDrRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHglvedgvavgtrywptrtiwhq
 .||   .|.  ...| |      .     .|||| .. |    | ..| .| | . | .||| |.|...|| .|                         
dknriinilafdknvvklerliGeef...sdyinasfvtGyqrkd.kyiaaqGPldntladfWrmiweyncstivllt......................

MPVMTTHGPKKTRKRTIRlNDYKIKLVHEAELdHAIySRIKLWK--GALGPRTLTHVWMLSTGSKREPQHARTWNTVVRD---VAGMRTGSAPVVVHCPL
    . . |.|. ..  |  . |...|.|..  ...   |.| .     . | .|   .|    .  |...    ..|.    .     . |..||||  
kdkcsqywplkivikeer.fkvkvdsveetae.yvv.rdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsa

GIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
|. |  |...||.|  .. ..   ||  .| .|||.|   ...| || |...| 
GvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 732-979 2.5e-22 74.2 In-house 9-235 (239) alignment 
Range on Protein: 732-979
Range on HMM: 9-235/239.0
SRNRSPSVLPNIHSRVYLSvDMSSDTalRDEYINANYMRGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIWHQ
..||   ..   |||| |   .| |   . .||||.|.|   |  . .| ||    ... |||.|.|..   |.|   ||.|       .|||  |  . 
aknryanivtydhsrvvle.klsndp..hsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

MPvmtthgpKKTRKRTIRLNDYKIKLVHEAELDHAiysriklwkgalGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAG-MRTGSAPVVVHCPLGIER
         . | ..|  . || |. .  ... ..              | . .  .     |  ||.| .   . | ..     |. | |.||  |. |
nl.......rvtlrktevfadyiirtfvmsqvgqt............eeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgr

GAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAA
   |. .| .  |  .| | |..  |  .|.||   ... ||| |.| |
tgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 732-979 2.6e-22 74.2 In-house 10-236 (239) alignment 
Range on Protein: 732-979
Range on HMM: 10-236/239.0
SRNRSPSVLPNIHSRVYLSvDMSSDTalRDEYINANYMRGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIWHQ
..||   ..   |||| |   .| |   . .||||.|.|   |  . .| ||    ... |||.|.|..   |.|   ||.|       .|||  |  . 
aknryanivtydhsrvvle.klsndp..hsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

MPvmtthgpKKTRKRTIRLNDYKIKLVHEAELDHAiysriklwkgalGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAG-MRTGSAPVVVHCPLGIER
         . | ..|  . || |. .  ... ..              | . .  .     |  ||.| .   . | ..     |. | |.||  |. |
nl.......rvtlrktevfadyiirtfvmsqvgqt............eeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgr

GAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAA
   |. .| .  |  .| | |..  |  .|.||   ... ||| |.| |
tgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 732-979 7e-22 72.5 In-house 50-274 (439) alignment 
Range on Protein: 732-979
Range on HMM: 50-274/439.0
SRNRSPSVLPNIHSRVYLSvdmSSDTALRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVavgtrYWPTRTIWHQ
..||  .| .  |.|| |             ||||||..|    |. .| ||.|.  |..||| .|... .. .|.   |||        |||. .    
tknrykdvgafdhtrvtlq...eipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcy

MPVMTthgpkkTRKRTIRLNDYKIKLVHeaeldhaIYSRI-KLWKgalgPRTLTHVWMLSTGSKREPQHARTWNTVVRDV--AGMRTGSAPVVVHCPLGI
  ..          | | | .| |. ..       .. .  .  |     ||. ..  ..   |  | .|      .| .  |  .    ||||||  |.
gdiav......rvdrnielpnyvirgfk.......vfnerdttek....ertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagv

ERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAA
 |    .||||   ||  .   |. | |  ||..|   ...| || |.. |
GrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiyna
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 732-829 3.5e-14 47.6 In-house 53-143 (297) alignment 
Range on Protein: 732-829
Range on HMM: 53-143/297.0
SRNRSPSVLPNIHSRVYLSVDMSSDtalRDEYINANYMRGLGGvdrRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVaVGTRYWPTRTIW
...|   .||   ||| | .  ..      .|.|| ...|      |.| || | ..| .||| ||.|.. |..|    . |      .|||. ... 
eksRYkniLPydssRvkLaivnddp...dsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvt
subfamily_egg_pd Subfamily egg 732-825 9.7e-12 39.2 In-house 42-129 (307) alignment 
Range on Protein: 732-825
Range on HMM: 42-129/307.0
SRNRSPSVLPNIHSRVYLsvDMsSDTALRDEYINANYMRGlGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDgvAVGTRYWPT
 . ||. |  .  ||| |  ..       |..| ||...| . .   |||.|||   | .||| ||. .|.  .|     .|        ||| 
ekarskrvhckdssrvkl..el.rrGqylddfihanrvkG.kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 733-978 4.7e-27 89.7 In-house 6-233 (237) alignment 
Range on Protein: 733-978
Range on HMM: 6-233/237.0
RNRSPSVLPNIHSRVYLSVDMSSdtalrDEYINANYMRGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIWHQM
.||  ..    |||| |    |.      .||||.|..|. |  ...| .| |  ..|.||| |||.. |||.|   ||.|       .|||        
knrygnivaydhsrvvlkgagsg.....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

PVMTTHGPKKTrkrtiRLNDYKIKLVHEAE-LDHAiysriklwkgalGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGM---RTGSAPVVVHCPLGI
 |.|    ||       . || .. .  .. |               . | .    . |   .  ||.. .     ...       . |.| ..||  |.
gvltvslkkke.....efsdytvrslllskrltlk............evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagv

ERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHA
 | ..|. .| .  |  ..   |.   |  . .||   |.. .|| |.| 
grtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihq
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 733-980 2.5e-24 81.3 In-house 28-251 (284) alignment 
Range on Protein: 733-980
Range on HMM: 28-251/284.0
RNRSPSVLPNIHSRVYLSVDMSSDTalrDEYINANYMRGLGGVDrRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHglvedgvavgtrywptrtiwhqM
.||   .|.  ...| |   .  .     .|||| .. |    | ..| || | . | .||| |.|...|| .|                          
knrighilafdknvvklerliGeef...sdyinasfitGyqrkd.kyiatqGPldntladfWrmiweyncstivllt......................k

PVMTTHGPKKTRKRTIRlNDYKIKLVHEAELdHAIySRIKLWK--GALGPRTLTHVWMLSTGSKREPQHARTWNTVVRD---VAGMRTGSAPVVVHCPLG
   . . |.|. ..  |  . |...|.|.|  ...   |.| .     . |...   .|    .  |...    ..|.    .     . |..||||  |
dkcsqywplkivikeer.fkvkvdsveesee.yvv.rdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsag

IERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
. |  |...||.|  .. ..   ||  .| .|||.|   ...| || |...| 
vgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 733-825 2.4e-11 38.1 In-house 36-124 (297) alignment 
Range on Protein: 733-825
Range on HMM: 36-124/297.0
RNRSPSVLPNIHSRVYLSVDMSsdtalRDEYINANYMRGL-GGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPT
.||   .|    .|| |   ..       .||||.|.       | ..||.| |  .| .|||..|..|.  |.|    | |||    . ||| 
knryrdilatddtrvkllrvit.....erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywps
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 733-826 6.7e-11 36.4 In-house 59-143 (290) alignment 
Range on Protein: 733-826
Range on HMM: 59-143/290.0
RNRSPSVLPNIHSRVYLSVDMSSDtalrdeYINANYMRGLggvDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTR
.||   |  |  .|| |.     |      |. |||..||   .  ||||| .   |  |.| || ... ...|    |.||| |   .|.| .
knrykdvvcndktrvilkdGydGd......yvhanyvkGl...kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypek
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 733-827 3.1e-08 27.5 In-house 55-144 (310) alignment 
Range on Protein: 733-827
Range on HMM: 55-144/310.0
RNRSPSVLPNIHSRVYLSVDMSSdtalRDEYINANYMRGlGGVDRRFILTQAPSPTTCEDFWHMVWDQEC-SVVVQCHgLVEDGVAVGTRYWPTRT
.||   |.    ||| | .| |      ..|| |||..    .   || .| |   |  ||| |.... . |... |.  .|.|      |||.  
knrysdvvcldtsrvklkidksr....yedyihanyvkt.nylrstficsqgplqhtiidfwrmifqeraesilllck.vgeegrpkcvgywpslg
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 734-806 2.6e-06 21.3 In-house 51-112 (303) alignment 
Range on Protein: 734-806
Range on HMM: 51-112/303.0
NRSPSVLPNIHSRVYLSvDMSsdtalrdeYINANYMRgLgGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVV
||   |.   ||.| || | |        || |.|.  |   ... |||| | . |. ||| |. .|   .|.
nrfvdvicldhskvkls.dss........yihasyle.l.dsskkailtqlplshtaadfwqmiieqkvkcvl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 741-978 6.7e-13 42.9 In-house 47-263 (281) alignment 
Range on Protein: 741-978
Range on HMM: 47-263/281.0
PN-IHSRVYLSVDMSSDTAlrDEYINANYMRGlGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTiwhqmpvmttHG
|    ||| | |.|    .   .|| |||.|    . | .|||| |   |  |||.|.|... . .|    ..|      . |.|  .          | 
pcldisrvqlkvkmpnkns..tdyihanyirs.pflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna..........hc

PKKTRKRTIRLNDYKIKlvheaelDHAIYSRIKLWKGAlGPRTLTHVWMLSTGSKREPQHARTWNTVVRDvagMRTGSAPVVVHCPLGIERGAVFVALDI
  .  | ..  .|  ..          . .|..|       | .||         . |. .     ..|    .|. |.| |.||  |. |   ..|..|
clqfdklsvsyedstvn.......kslvttrlnlsyeg.etrlithwlwkewpdwqvpessevmlkilrk...irarstppvihcsagvgrsgtlmavei

L-QMQLIQQGTADVLGTVCQLRQ-DRGLCINSLEQYRFLHA
  |    .    |.   | .||   |   ...|.|| ..  
alqsihshftlpdikqivshlrvtgraasvqtlqqymliwk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 746-983 2.6e-21 70.6 In-house 56-292 (301) alignment 
Range on Protein: 746-983
Range on HMM: 56-292/301.0
RVYLSVDMSSDtALRDEYINANYMRGLGGvDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIWHQMPVMTTHGPKK---
|. |.   . |   . |||||.|. |     ..|| .|.|   |  |||...|..  . .|   .| |.  .  ..|||. .  ..  .  |   ..   
riilkpkpnld.lcqreyinasyidgyse.kkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqv

TRKRTIRLNDYKIKLVHEaelDHAIYSRIKLWKGAlGPRTLTHVWML---STGSKREPqhaRTWNTVVRDVA--GMRTGSAPVVVHCPLGIERGAVFVAL
    .||    ||. . .   .  | ...|  .    ..... . .      |  |||   ||   |. ||     . | .||||||  .. |  |....
yPdfvirqlnvkiqdgsn...ngyierkfkvksdk.sswdvlqlqvtdWpqdGvvrep...rtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsv

DILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTF
.|   |   .|  || . .  .|. .   .  |||| ... .  ..
siglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy
subfamily_eak_pd Subfamily eak 747-994 2.6e-11 37.5 In-house 64-315 (332) alignment 
Range on Protein: 747-994
Range on HMM: 64-315/332.0
VYLSVDMSSDTALRDEYINANYMRgLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRT--IWHQmPVMTTHGpKKTR
 .  | ..|    |. ||||  .  .  | |..||| ..| .    || || .|    .||    || ..    .|.| .|   ..   ..  .  |.  
drylvrltssqlnrlGyinaslae.fsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkf.Gildver.kefv

KRTIrLNDYKIKLVHEAELDHAIYSRIKLWKGALGPRTLTHV----WMLSTGSKREPQ-HARTWNTVVRDVAGMRTGSAPVvVHCPLGIERGAVFVALDI
|| | |.  ...|    |  .  . ..  |     |.    .     |  .|     . ..   .....         ||. . .  |  |  ||| .|.
krni.letrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapi.iqsarGsaraGvfvvidl

LqMQLIQQGTA---DVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTHENQLGRA
| ..||..       |   . . .. |  ..    |. |.. .   . .. .|.|   
l.irlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrdl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 756-989 3.7e-13 44.3 In-house 41-264 (290) alignment 
Range on Protein: 756-989
Range on HMM: 41-264/290.0
DTALRDEYINANYMRGLGGVdrRFILTQAPSPT-------TCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTrYwptrtiwhqmpVMTTHGPKKTrKRTI
 . . |.|| ||..    |.  |.||||.|          | |.|| |. . .   ||.     |     ..               .   |..     .
gkrfnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantsl.f...........aCakYvpesv.geel

RLNDYKIKLVHEAELDHAIYSRIKLWKGALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAgmrTGSAPVVVHCPLGIERGAVFVALDIlQMQLIQ--
.... ..|  .  . |  .  .. .  .   . |.|| .. .  .   ... .|  .... |    .  .||.|||  || | |.. |...  .|.|   
kfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk...asktpvivHcvdGiSrsAalaaiil.gyQkiaet

QGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTHEN
.|   .   . .||. | |.| | ... |  |..   |    .
sgsvkledvlkalrkqralaitsalelafvdagivllaievld
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 758-985 3.5e-17 57.1 In-house 70-288 (305) alignment 
Range on Protein: 758-985
Range on HMM: 70-288/305.0
ALRDEYINANYMRGlGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTiwhqMPVMTTHgpKKTRKRTIRLNDY-KIK
.   ||| |||.       .||| ||||   || |||.| ...    .     |.| |    . |....      .|.. .  .| .| .....   ..|
pwpheyihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskd....kdvlefe..ekgqkisvkfessvtlk

LVHEAelDHAIYSRIKLWKGALGP-RTLTHVWMLSTGSKREPQhARtwNTVVRDVAGMRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQG-TADVLG
....|  .  .   . . .|. .  |  ||        .  |  |   ....  ..  |.   |.||||  || |    | |. .  ||..     |   
frkda..kakvtetvlviegpgekarkvthyhwidwpdrgvpa.ad..lailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdk

TVCQLRQDRGLCINSLEQYRFLHAAAWTFAR
 . ..|..|   |.. .|| |.|     . |
ilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 760-825 2.7e-08 27.8 In-house 79-144 (305) alignment 
Range on Protein: 760-825
Range on HMM: 79-144/305.0
RDEYINANYMRGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPT
  .|| |||.      ..||| .| |   | ..|| || ..    .|     || |    ..|||.
psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpa
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 760-826 3.8e-06 21.2 In-house 12-72 (130) alignment 
Range on Protein: 760-826
Range on HMM: 12-72/130.0
RDEYINANYMrGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQChGLVEDGvavgTRYWPTR
 ..||||... || |  . ..|||.|   |. |||.|. ..   |.|   | ||.       |||  
gntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvl.gsveee....deywpds
0051429 (Phosphotyrosine protein) phosphatases II 761-985 7.1e-24 80.3 In-house 4-226 (272) alignment 
Range on Protein: 761-985
Range on HMM: 4-226/272.0
DEYINANYMRGLGG--VDRRFILTQAPSPTTCEDFWHMvWDQECSVVVQCHGLVEDGVAVGTRYWpTRTIWHQMPVMTTHGPKKTrkrtirLNDYKIKLV
. ||||... |.|.  ...|......|.| |..|||.. ... ....|   ...| |     |||     ....|.. .. |  .      .... ..|.
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdryw.pgirylhlpilddsaptil......ygalrvtll

HEAELDHAIYSRIKLWK--GALGPRTLTHVWMLSTGSKREPQHArtWNTVVRDVAGmrtgSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTAD-----
.|  |.. |. .. |..  .|  .|...| ....      ||.|    .... ..     . ||.|||  |. | ...|||..| ...  .  .|     
seellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

---VLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFAR
   ....| .||. |   . . |||.||. |.. ..|
nlyleeaveelraqrpgavqteeqylflyeallellr
0036282 (Phosphotyrosine protein) phosphatases II 761-977 1.4e-23 78.9 In-house 2-163 (174) alignment 
Range on Protein: 761-977
Range on HMM: 2-163/174.0
DEYINANYMRGLGGVDrRFILTQAPSPttcedFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTrtiwhqmpvmtthgpkktrkrtirlndykiklvhe
. ||||... .    . |.|..|.| .     ||.|.... ...||..  ..|.|     .|||.                                   
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

aeldhaiysriklwKGALGPRTLTHVWMLSTGSKREPQHARtWNTVVRDVAGMRTG--SAPVVVHCPLGIERGAVFVALDILQMQLIqQGTADVLGTVCQ
              .     |.  ... | .    .|  .  . ..|. |   .    . ||.|||  |. | ...||.... ..|. ... |.| .| .
..............lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvre

LRQDRGLCINSLEQYRFLH
||. |. .. . .|||||.
lRlqrpgmvqtpsQyrfly
0051082 (Phosphotyrosine protein) phosphatases II 761-978 6.9e-17 56.9 In-house 3-147 (151) alignment 
Range on Protein: 761-978
Range on HMM: 3-147/151.0
DEYINANYMRGLggvdrrFILTQAPSPttceDFWHMVWDQECSVVVQCHGLVEDGvaVGTRYWPTRTiwhqmpvmtthgpkktrkrtirlndykiklvhe
. |||..|. |       ......|..    ||. ..... ....| . ...| |    ..|.|                                    
sdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

aeldhaiysriklwkgalgpRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGmrTGSAPVVVHCPLGIERGAVFVALDILQMQliqqgtADVLGTVCQLR
                    ....|...|..     |..  . . ... ..   ... ||.|||  |. | ...|||... ..       ..  .. ..|
....................ievlhipildwpdpglplsfdavleflellld..kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyr

QDRGLCINSLEQYRFLHA
. |. .... .|..|.. 
lkrpgvvqpnqqflfqlf
0043147 (Phosphotyrosine protein) phosphatases II 762-978 1.6e-22 75.4 In-house 6-155 (172) alignment 
Range on Protein: 762-978
Range on HMM: 6-155/172.0
EYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLvedgvavgtrywptrtiwhqmpvmtthgpkktrkrtirlndykiklvhea
 ||||.|. .   . .||| ||.| . |..|||.|.... ....| . .|                                                  
dyinasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltel..................................................

eldhaiysrikLWKGALGPRTLTHVWMLSTGSKREPqHARTWNTVVRDVAG--MRTGSAPVVVHCPLGIERGAVFVALDILQmqliqqGTADVLGTVCQL
           |  . |  |.  ... |.      | ... .  ... .     .  . ||.|||  |. | ...||.....         ... .|...
...........lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalv

RQDRGLCINSLEQYRFLHA
|. |. .. . .|||||. 
rekRpgavqnpsqyrflyy
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 762-978 4.6e-17 56.9 In-house 60-264 (285) alignment 
Range on Protein: 762-978
Range on HMM: 60-264/285.0
EYINANYMRGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRtiwhqMPVMTthgpkKTRKRTIRLNDYKIKLVHEA
.|| |..||  |  .  .| || | | |  |||||..... . |.    |.| ||   . |.| .     .  .      |  |  | | . | . .  .
dyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypek.....lgevv.....kfgkyeitlteckeeaiagt

ELDHaiYSRIKLWKGALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQ
 |.    . |.    .  |  . || .     .  |. ||    . . |  .     |..|||  |. | | || .|   ......   ..|  | ..| 
ilna..ltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremra

DRGLCINSLEQYRFLHA
 |  ...|  |. ||. 
mrfqavqshmqflflyv
0044763 (Phosphotyrosine protein) phosphatases II 762-978 5.9e-15 50.8 In-house 19-165 (178) alignment 
Range on Protein: 762-978
Range on HMM: 19-165/178.0
EYINANYMRglggvdRRFILTQAPSpttcEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIwhqmpvmtthgpkktrkrtirlndykiklvhea
.||||...        ...|...|.    .|.. ..... ....| . . .| |     .|||...                                  
dyinaseil......pglylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.................................

eldhaiysriklwkgalgprtLTHVWMlSTGSKREPQHARTWNTVVRDVAGMR-TGSAPVVVHCPLGIERGAVFVALDILQMQliqqgTADVLGTVCQLR
                     ......  .    .|.  . .  .|. .   . .   ||.|||  |. | ...||.... ..       ..   . ..|
.....................iqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvr

QDRGlCINSLEQYRFLHA
. |  .. . .|.|.|. 
erRp.ivpnpgqlrqLye
0046846 (Phosphotyrosine protein) phosphatases II 763-980 1.4e-22 75.7 In-house 14-169 (176) alignment 
Range on Protein: 763-980
Range on HMM: 14-169/176.0
YINANYMRGLggvdrRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTrtiWHQMPVmtthgpkktrkrtirlndykiklvheae
|||||.. |      |.| ||.| | |..||..|.... ...|| .  .|| |    ..|||    .... .                            
yinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi............................

ldhaiysriklwkgalgprtltHVWMLSTGSKREPQHaRTWNTVVRDVAGMRTGSAPVVVHCPLGIERGAVFVALDilqmqLIQ-QGTADVLGTVCQLRQ
                      ... | .     |.. . . .... .  ...   ||.|||  || | ...||..     |.. .   .|. .....|.
......................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvre

DRG-LCINSLEQYRFLHAAA
 |   .. . ||||||. ..
qRplgavqtpeQyrflyefe
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 764-975 6.1e-18 59.6 In-house 78-272 (301) alignment 
Range on Protein: 764-975
Range on HMM: 78-272/301.0
INANYMRGLgGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIwhqmpvmtthgpkktrkRTIRLNDYKIKLVHE-AE
| ||..    |  .||| ||.| . |.|||| |.   .   .|     ||. . . . | |...                  ...... .|||....   
ihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis.................ekldigrfkikiknkeli

LDHAIYSR---IKLWKGALGPRTLTHVWMLSTGSKREPQ-HARTWNTVvrDVagMRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQ
|.. |. |   ..   | . .||.||    .   .  |. || ... .  ..  ..    |.||||. || |   |.. ..|  ..  . | ..  .. .
lnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlm..el..vkksekPivvhcsaGiGrsvafigteylareveadptieltealkh

LRQDRGLCINSLEQYRF
||..|   ..  .|  .
lrehrwngvqtnsqlyw
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 776-977 1.8e-10 35.3 In-house 4-197 (199) alignment 
Range on Protein: 776-977
Range on HMM: 4-197/199.0
DRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIWHqmpvmTTHGPKK-TRKRTIRLNDYKIKLVHEAELDHAIYSriklw
.||.| || |   |  ||| |||.     .|       .  |    ||||          . .|    | |      || |  .  ..   |  |     
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgt.....gkygslsvttktittkpdytitaliltnnttapps.....

kgalgPRTLTHVWMLSTGSKREPQHARTWNTVV--RDVAGM--RTGSAPVVVHCPLGIERGAVFVALDILQMQLIQ--QGTADVLGTVCQLRQDRGLCIN
      | ..|  . |   |  |. |     ||  |.|.    .   |||.|||  |     |||||||      .      |..    .||| |   | 
.....treishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiis

SLEQYRFLH
||..| |..
slqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 776-977 1.8e-10 35.4 In-house 3-196 (198) alignment 
Range on Protein: 776-977
Range on HMM: 3-196/198.0
DRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIWHqmpvmTTHGPKK-TRKRTIRLNDYKIKLVHEAELDHAIYSriklw
.||.| || |   |  ||| |||.     .|       .  |    ||||          . .|    | |      || |  .  ..   |  |     
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgt.....gkygslsvttktittkpdytitaliltnnttapps.....

kgalgPRTLTHVWMLSTGSKREPQHARTWNTVV--RDVAGM--RTGSAPVVVHCPLGIERGAVFVALDILQMQLIQ--QGTADVLGTVCQLRQDRGLCIN
      | ..|  . |   |  |. |     ||  |.|.    .   |||.|||  |     |||||||      .      |..    .||| |   | 
.....treishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiis

SLEQYRFLH
||..| |..
slqhynfiy
0049260 (Phosphotyrosine protein) phosphatases II 777-977 4.1e-20 67.5 In-house 9-143 (152) alignment 
Range on Protein: 777-977
Range on HMM: 9-143/152.0
RRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWptrtiwhqmpvmtthgpkktrkrtirlndykiklvheaeldhaiysriklwkg
..|| ||.| | |..|||.|.... ....| .  |.|.|     .|.                                                     
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.....................................................

algprTLTHVWMLSTGSKREPQHARTWNTVVRDVagMRTGSAPVVVHCPLGIERGAVFVALDILQmqliqqGTADVLGTVCQLRQDRGLCINSLEQYRFL
     .  |...   |    .|. .  . ...     .  . ||.|||  |. | ...||....          ... .| ..|. |   . . .|.|||
.....qylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfl

H
.
y
0048076 (Phosphotyrosine protein) phosphatases II 843-979 2.6e-11 38.9 In-house 18-138 (145) alignment 
Range on Protein: 843-979
Range on HMM: 18-138/145.0
TRKRTIRLNDYKIKLVHEAeldhaiY------SriklwkgalgpRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRTGSAPVVVHCPLGIERGAVFVA
| ..  .| |..|..|                .           |. .... |..    .|. .... .... .   .    ||.|||  |. | ...||
taldlellkdlgittvlnl......tselelle...........rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlva

LDILQMqliqQGtADVLGTVCQLRQDRGLCINSLEQYRFLHAA
.... .    .|  ..  .. ..|. |  .. . .|.|||. .
aylmll....lg.vsleealelvrsqrpgavpnpgqlrflyef
0048179 (Phosphotyrosine protein) phosphatases II 873-978 1.3e-10 36.7 In-house 48-139 (144) alignment 
Range on Protein: 873-978
Range on HMM: 48-139/144.0
LwkgalgprtLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRTGSAPVVVHCPLGIERGAVFVALDILQmqliQQGtADVLGTVCQLRQDRGLCINSLEQ
           .... |..     |...  ...... .   .  . ||.|||  |. | ...||....      .|  ..  .. ..|. |  .. . .|
e.........giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgq

YRFLHA
.|||. 
lrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 879-980 6.6e-07 23.0 In-house 87-190 (440) alignment 
Range on Protein: 879-980
Range on HMM: 87-190/440.0
GPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAG--MRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFL
  ||| .  . .   |  |. |     ...||     ..|..|..|||  |  | .| .|.| .  .  .    |..  .  .|..|   ... ||| |.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HAAA
| | 
heav
subfamily_PTPRN_pd Subfamily PTPRN 881-979 4.4e-09 30.4 In-house 187-287 (297) alignment 
Range on Protein: 881-979
Range on HMM: 187-287/297.0
RTLTHVWMLSTGSKREPQHARTWNTVVRDVA-GMRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQ-GTADVLGTVCQLRQDRGLCINSLEQYRFLHA
||.|    ||  ..  |  |..     | |    |  |.|.||||  |  |  |....|..  .|..     |.  |.  ||..|   ... .|..|  .
rtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt

A
|
a
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 884-988 6.5e-07 23.1 In-house 188-289 (302) alignment 
Range on Protein: 884-988
Range on HMM: 188-289/302.0
THVWMLSTGSKREPQHARTWNTVvrdVAGMRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTF
.. |  ... ..  . ..|   |    |    .....|.    |. | ..|..| .   .| ..    .  .| ..|..|   ..||.|| .|. |. ..
ltnWkqkkvpvkyaeliktaakv...fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiallly

ARTHE
 ... 
ikkkv
subfamily_CG42327_pd Subfamily CG42327 891-985 1.2e-11 38.9 In-house 219-316 (319) alignment 
Range on Protein: 891-985
Range on HMM: 219-316/319.0
TGSKREPQH--ARTWNTVVRDVAGMRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQ-GTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFAR
 ||| |     ..  |  .   .| |    |.||||  |. |  . .| ||   .| .   . |.  .| ..|.||.  . . ||| |..  .  .|.
dgskaeagstssheingnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
PTPc_DSPc_SM00012 903-979 1.7e-16 55.7 In-house 22-102 (105) alignment 
Range on Protein: 903-979
Range on HMM: 22-102/105.0
WNTVVRDVAGMRT---GSAPVVVHCPLGIERGAVFVALDILQMQLIQQ-GTADVLGTVCQLRQDRGLCINSLEQYRFLHAA
  ...|.|   ..    |.||||||  |. | ..||||||| .|| .. .. |.. .|..||. |  .....||| ||..|
ilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyra
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 905-976 8.1e-08 26.2 In-house 204-275 (290) alignment 
Range on Protein: 905-976
Range on HMM: 204-275/290.0
TVVRDVAGMRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFL
...| .  .|. | ||||||  || |   |||...    |..    |.|..|  ||. |   ..   ||  |
allrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylal
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 907-980 8e-11 36.6 In-house 208-280 (297) alignment 
Range on Protein: 907-980
Range on HMM: 208-280/297.0
VRDVAGMRTGSaPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
||.. . .. . |..|||  |. | .|....|    .  .. . |..|.| .|||.|   .   |||.|.. | 
vrkdfsqnaeg.PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvav
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 909-990 5.6e-06 20.1 In-house 217-296 (310) alignment 
Range on Protein: 909-990
Range on HMM: 217-296/310.0
DVAGMRTGsaPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTHENQ
 .| .| |  |.||||  |..|  | |||..   .| .    |.   . .|...|  ||..  || ...     |||.....
llaqvrhg..pcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifargetev
subfamily_egg_pd Subfamily egg 913-985 4e-08 27.3 In-house 197-271 (307) alignment 
Range on Protein: 913-985
Range on HMM: 197-271/307.0
MRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTA--DVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFAR
.|  | ||||.. ||. . |..||..|  ..|..  .    || .|  ||. | | ..|  .| |..     | |
lrnlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
subfamily_PTPRA_pd Subfamily PTPRA 916-983 2.2e-09 31.6 In-house 228-294 (330) alignment 
Range on Protein: 916-983
Range on HMM: 228-294/330.0
GSaPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTF
.. |.||||  |. |   |..|| .  ..  ..  || ..| .||. |   ....||| |.. .   .
ag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 917-980 2.6e-07 24.8 In-house 228-291 (297) alignment 
Range on Protein: 917-980
Range on HMM: 228-291/297.0
SAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
.|...|||  |. |  | |  |..  .| ..   ||   . .||. |   ...|||. .|. |.
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav