Gene MbrePTP-Un-9 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP063_AA protein Get Run
MbreP063_AA_691-985 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
GF_recep_IV Growth factor receptor domain IV 97-186 2.8e-09 23.2 Pfam-A 10-98 (132) alignment
Range on Protein: 97-186
Range on HMM: 10-98/132.0
RCVGPALDECTKCQpdaGFLLETTCVASCPISTFAQGTNDDasGRTCQDCAPGC------AQCS--NPTTCTACLPNWyiglDNATCVQACPNGFGGQ
 | ||  ..| .|.    |  |..||.|| . .. . .  .   ..|..| | |      . ||  ....|..|        |. .||. ||.|  |.
gCWGpgpeqClsCk...kfsrekeCvescnllegekreyee..ekkCvkChpeCekqeesetCsgpgadeClkCahfk....dgkeCvseCPegvkge

0050432 (Phosphotyrosine protein) phosphatases II 674-988 3.2e-56 186.3 In-house 9-303 (308) alignment
Range on Protein: 674-988
Range on HMM: 9-303/308.0
VPKWTQMGDKFRGRMTQSRPLNVSQLEASSRDPTMLQSEYESIPPNAASVD---ELPSGVESRNRSPSVLPNIHSRVYLsvdmssdtALRDEYINANYMR
...........   ... . |.. .|  .  |...|. |.| .. .  . .    |     ..||....||. ||||.|           . ||||.|..
lelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl........degsdYInAsyvd

GLG-GVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTR---TIWHQmpvmtthgpkktrkrtirlNDYKIKLVHEAELDHA
|   ...|.||.||.| |.|.||||.|||.|...|.|    |||.|.    .|||.    ....                    ......|..| .||. 
gyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsley...................gkftvtllseevlddy

IYSRIKLWK-GALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRtGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGL
..  ..|.. |    ||.|| ....      |....   . .. |  .. .. |.||||  |. | ..|.|||.|  || ..|. ||...|..||. |  
tvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpg

CINSLEQYRFLHAAAWTFARTHE
.....|||.||. |.  ......
mvqtpeqylflyralleylklkl

subfamily_PTPRA_pd Subfamily PTPRA 693-831 1.4e-18 61.9 In-house 13-155 (330) alignment
Range on Protein: 693-831
Range on HMM: 13-155/330.0
PLNVSQLEA-----SSRDPTMLQSEYESIPP-NAASVDELPSGVE--SRNRSPSVLPNIHSRVYLSVDMSSDTAlrdEYINANYMRGLGGVDrRFILTQA
|| | .||      |. |  ... |....|  .  .. || |  |   .|| . .||. .|||.|||    ...   .|||| .. |    | .|| .| 
plpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGvees...dyinasfidGykekd.kfiaaqG

PSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIWHQ
|   | |||| |.|.|. . .|    | |      ..|||.  ..  
PkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvty

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 696-980 3.4e-28 93.5 In-house 15-275 (315) alignment
Range on Protein: 696-980
Range on HMM: 15-275/315.0
VSQLEASSRDptMLQSEYESIPPNAASVDELPSGV--ESRNRSPSVLPNIHSRVYLSVDMSSDtalRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDF
|.| .||...   .. .|||||       .    .    .||   ...  .|||.| .    .     .|.|||.. |     ||.| .|.| ... .||
vaqkkastkn..gfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendp...hsdyvnanfidGyn.kkrryiaaqgpnvasvkdf

WHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIWHQMPVMTTHGPKKTRKRTIRLNdykiKLVHEAELDHAIYSRIKLWKGALGPRTLTHVWMLStgs
| .|...... .|   .|||.      .||| . . .    .|    ..  . |.|        | . .. . .  ..  |  .  |.  . .  |    
wrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtl....svvfgdnirevvqlhytswpdmgvpkytiplmnli...

krepQHARTWNTVVRdvagmrtgsAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
    .... ..|            ...||||  |. |   |..|| .  |.  .   ||   . ..|| |   ....|||.|.. | 
....rtvkqhhtnsv.........gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal

subfamily_Ptp69D_pd Subfamily Ptp69D 698-982 2.5e-36 120.4 In-house 12-284 (307) alignment
Range on Protein: 698-982
Range on HMM: 12-284/307.0
QLEASSRDP-TMLQSEYESIPPNAASVDELPSGV---ESRNRSPSVLPNIHSRVYLSVDMSSDTAlrdEYINANYMRGLGGvDRRFILTQAPSPTTCEDF
.|... ||.   |. |||... .  . .   |       .||.. . .  . || |..   ....   .||||....|     ..||  |.|  .| .||
alksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkeds...dYinasfikgyke.kkkfiaaqdPveatigDf

WHMVWDQECSVVVQCHGLVEDGVAVGTRYWP--TRTIWHQMPVMTTHGpKKTRKRTIRLNDYKIKLVHEAELdhaiysriklwkgaLGPRTLTHVWMLST
| |...||  ..|    | |   .   .|||  . . . .. | . .  .|. . .||  |.  |  . .|.                 | ..    .. 
WRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvse.ekhsdyiiReldvskkkeesgev..............edsrkvvqyhytgW

GSKREPQHARTWNTVVRDV-AGMRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWT
     |..||.   ... |    ..  .|.|||| .| .| ..|||||.|  || .  ..|.  ||..||..| | ..||||| ||. |   
kDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralld

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 701-981 7.2e-35 115.4 In-house 15-276 (288) alignment
Range on Protein: 701-981
Range on HMM: 15-276/288.0
ASSRDPTMLQSEYESIpPNAASVDELPSGVESRNRSPSVLPNIHSRVYLSVDMSS-DTALRDEYINANYMRGLGGvDRRFILTQAPSPTTCEDFWHMVWD
.| |. | ...||.|. ..  . ..   | ...| .    .|| .  .  | .   ..    .||||.|. | .. ....| ||.| . | .|||..|..
ksarnrtgfseeynsL.aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekk.kkkyiatqgPladtvndfWelvye

QECSVVVQCHGLVEDGVAVGTRYWPTRTiwhqMPvmTTHGpkktrkrtirlnDYKIKLVHEAELDHAIYSRIKLWKGAlGPRTLTHVWMLSTGSKREPQH
.. | .|   .|||.|     .|||.       |  . .|            . ...||.. ||.. .  .. | |   . ...|.   |.   .  |. 
nktstivmltelveggktkCeeYWPdad....kp..knyG............svtvtlveskeledfvlrklllekkk.teleitqyqylaWpdhgvPes

ARTWNTVVRDVAGMRTGS-APVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAW
..    ..| |    .    |..|||  |. |  .|.||| |  .. .. . ||.|||..||. | | .. |.|| |.. .  
kapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll

0039614 (Phosphotyrosine protein) phosphatases II 702-983 1.8e-47 157.6 In-house 27-288 (297) alignment
Range on Protein: 702-983
Range on HMM: 27-288/297.0
SSRDPTMLQSEYESIPPNAASvDELPSG--VESRNRSPSVLPNIHSRVYLSVDMSSdtALRDEYINANYMRGLGGVDRRFILTQAPSPTTCEDFWHMVWD
   ..|.|. |.|... .  .  .        ..||....||. ||||.|.. ...   | . ||||.|. |   ..|.||.||.|.| |.||||.|||.
kansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgv..dldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

QECSVVVQCHGLVEDGVaVGTRYWPTRtiwhqmpvmtthgpkkTRkrtiRLNDYKIKLVHEAELDHAIYSRIKLWKgALGPRTLTHVWMLSTGSKREPQH
| ..|.|    |||.|.    .|||..                .     . .|....|. . .||. ..  .....    .||.||.. ..      |..
qgvtvivmLtklvelgr.kcaqywpee................gg....tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvpps

ARTWNTVVRDVAGMRT---GSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTF
...   ... |   .    .. ||.|||  |. | ..|.|....  ||   |. ||| .|..||. |. .. ...|||||. |.  .
lellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel

0051299 (Phosphotyrosine protein) phosphatases II 703-983 1.5e-52 174.2 In-house 19-285 (288) alignment
Range on Protein: 703-983
Range on HMM: 19-285/288.0
SRDPTMLQSEYESIPPNAASVD---ELPSGVESRNRSPSVLPNIHSRVYLSVDMSsdtALRDEYINANYMRGlGGVDRRFILTQAPSPTTCEDFWHMVWD
 ...|.|. |.| .... ....    |     ..||....||. ||||.|||  .      . ||||.|..|    .|.||.||.| |.|.||||.|||.
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg...vegsdYinAsyidg.ynlkrkfIatqgPlpntvedFWrmvwe

QECSVVVQCHGLVEDGVAVGTRYWPTrtiwH----QmpvmtthgpkktrkrtirlNDYKIKLVHEAELDHAIYSRIKLWK-----GALGPRTLTHVWMLS
|...|.|   .|||.|.    .|||.    .                        .|....|..| .||. ..  ... .     |   .|| || ....
qnvrvIvmltklvelgrekcaqYwpl....ggslty...................gditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytn

TGSKREPQHARTWNTVVRDVAGM-RTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTF
      |.... . . .|.|  . . |. ||||||  |. | ..|.|||.| .|| ..|. |||..|..||. |  .....|||||.. |.. .
wpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley

0047943 (Phosphotyrosine protein) phosphatases II 703-981 3.2e-48 159.9 In-house 8-269 (273) alignment
Range on Protein: 703-981
Range on HMM: 8-269/273.0
SRDPTMLQSEYESIPPNAASVD---ELPSGVESRNRSPSVLPNIHSRVYLsvdmssdTALRDEYINANYMRGlGGVDRRFILTQAPSPTTCEDFWHMVWD
. ..|.|. |.| ....  ...    |     ..||....||. ||||.|       .   . ||||.|..|   . |.||.||.| | |.||||.|||.
llgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.......gdggsdyinAsyvdg.ynlkrkfiatqgPlpntvedfwrmvwe

QECSVVVQCHGLVEDGVAVGTRYWPTRtiwhqmpvmtthgpkkTRKRTIRLNDYKIKLVHEAELDHAIYSRIKLWK-GALGPRTLTHVWMLSTGSKREPQ
| ..|.|    |||.|     .|||.                   . ... ......|. | . |. .   ..|.. |   .|| ||.....      |.
qnvrviVmLtelvelgrekcaqYwple................ggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvpp

HARTWNTVVRDVAGMRT---GSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAW
.     . ...|  ..    .. ||||||  |. | ..|.|||.|  ||.  |. ||| .|..||. |  .. ..||||||. |. 
slesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall

0036941 (Phosphotyrosine protein) phosphatases II 704-987 1.4e-47 157.8 In-house 10-280 (297) alignment
Range on Protein: 704-987
Range on HMM: 10-280/297.0
RDPTMLQSEYESIPPNAASVD---ELPSGVESRNRSPSVLPNIHSRVYLsvdmssdTALRDEYINANYMRGLgGVDRRFILTQAPSPTTCEDFWHMVWDQ
 ....|..|.|...|. .. .    |  .  ..||....||. |.||.|       .   . ||||.|. |  ...|.||.||.| |.|.||||.|||.|
lflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.......ddegsdYinAsyvdgy.dlkrkfIatqgPlpntvedFWrmvweq

ECSVVVQCHGLVEDGVAVGTRYWPtrtiwhqmpvmT-------ThgpkktrkrtirlNDYKIKLVHEAE--LDHAIYSRIKLWK-GALGPRTLTHVWMLS
 ..|.|    |||.|     .|||           .                     .|....|... .  ||. ..  ..... |   .||.|| ....
nvtvIvmltelvelgrekcaqywp...........leegeslty.............gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytg

TGSKREPQHARTWNTVVRDVAGMRT---GSAPVVVHCPLGIERGAVFVALDILQMQLI---QQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFA
      |.....    .. |  ..    .. ||.|||  |. | ..|.|.|.. .||     .|. |.| .|..||. |  .. .|||||||. |   . 
wpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

RTH
...
kkk

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 705-985 1.2e-52 173.7 In-house 3-269 (274) alignment
Range on Protein: 705-985
Range on HMM: 3-269/274.0
DPTMLQSEYESIPPNAASVDELPSGVESRNRSPSVLPNIHSRVYLSVDMSSDTALrdEYINANYMRGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSV
... |..|. ..| |    ..  .| ...||  ..||| .||| |. . |.|  .  .||||||..| ..... .. || | |.| .|||.|.. .|..|
sfkdlekeflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededs..syinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqv

VVQCHGLVEDGVAVGTRYWPtrtiwhqmpvmtthgpkK--TRKRTIRLNDYKIKLVHEAELDHAIYSRIKLWKGALgPRTLTHVWMLSTGSKREPQHART
.|    | |   .  ..|.|                 .    . . | .| .|| ..  | ..    .. | .    .|...| |  .   .. |..|.|
ivmltklkeaneqkCavyfP.................daedyeiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddant

WNTVVRDVAGMRTG----SAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFAR
   .|..|   |.      |||||||  || |  .|.| .|   || .... |||..||.||.|||  ... |||...| |   ...
lldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

subfamily_PTPRD_pd Subfamily PTPRD 705-987 1.4e-42 141.1 In-house 21-284 (564) alignment
Range on Protein: 705-987
Range on HMM: 21-284/564.0
DPTMLQSEYESIPPNAASVDELPSG--VESRNRSPSVLPNIHSRVYLSVDMSSdtaLRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQEC
. . ...||..| ..  .  |  .     ..||   ...  |||| ||           .||||... |    .. .| ||.| ..|.|||| |||.|..
sdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegd...egsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqns

SVVVQCHGLVEDGVAVGTRYWPTR-TIWHQMPVMTTHgpKKTRKRTIRLNDYKIKLVHeaeldhaiysriklwkgALGPRTLTHVWMLSTGSKREPQHAR
|..|    |.| |     .|||.. |  ..  . | .  ..... .. . . |.|  .                     |. ..    |  ..  |..|.
stiVmltkleEkgkvkchkYWPekgtetygeltVtle..eeeeladyeirtfklkkkk.................ssesreVrqFhFtsWPdhgvpesat

TWNTVVRDVAGMR-TGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTH
.  ...|.|  .. ... |.||||  |..|  .|...|..  .. ...| |. ..| .||..|   . . ||| |.| |   .    
slLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 705-980 1.5e-31 104.7 In-house 20-279 (305) alignment
Range on Protein: 705-980
Range on HMM: 20-279/305.0
DPTMLQSEYESIPPNAASVD-ELPSGVESRNRSPSVLPNIHSRVYLSVDMSSDtalRDEYINANYMRGLGGVDrRFILTQAPSPTTCEDFWHMVWDQECS
. . |. .|.|.. .  |.| .  .  ...||. .. .  ..|. |. . | |     .||||.|. |  . . ..|..|.| ..| .|||.....   |
sdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekesld...dsdyinasyvdgykrkk.kyivaqgPlkntvadfWrliveekvs

VVVQCHGLVEDGVAVGTRYWPTRTiwhqmpvmtthgpkkTRkrTIRLNDYKIKLVHEAELDHAIYSRIKLWK--GALGPRTLTHVWMLSTGSKREPQHAR
..|.  .|||.|     .|||...               |.  . ........|  |..    |  ..|. .  .    ||...  . .   .  || | 
tivmltklveggkdkCrqYWpesk...............te..kkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfat

TWNTVVRDVAGMRTGS--APVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
.  .....|   .  .   |..|||  |. |  ||.|.||   .| . .. || . . |||. |   ...|.|| ||| | 
sllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdal

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 706-982 1.1e-38 128.1 In-house 19-278 (318) alignment
Range on Protein: 706-982
Range on HMM: 19-278/318.0
PTMLQSEYESIPPNAASVDELPS---GVESRNRSPSVLPNIHSRVYLSVDMSSdtaLRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQEC
 ..|..||| . .. ..| .| |     . .||   .|.  |.|| |.   ..      .||||||. |    .. .| .||| | |.|||| |||.|..
elllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlege...egsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvWeqns

SVVVQCHGLVEDGVAVGTRYWPTRTiwhqmpvmtthgpkktrkrTIRLNDYKIKLVHEAELDHAIYSRIKLWK-GALGPRTLTHVWMLSTGSKREPQHAR
.|.|    ..| | |   |||| .                    .. ... ...| .| ||.. .  ..|. . .    |.     . |   .  |... 
avivmltqeeergkakvhryWPskg...................srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesga

TWNTVVRDVAGMR--TGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWT
.   .||.|  .   .|  |.||||  |. |  ||.|.|||  .. .... ||..|| |||. | | .   .|| |.. .   
slldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlle

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 706-989 3.3e-35 116.7 In-house 22-288 (319) alignment
Range on Protein: 706-989
Range on HMM: 22-288/319.0
PTMLQSEYESIPPN-AASVDE-LPSGVESRNRSPSVLPNIHSRVYLSvdmSSDTALRDEYINANYMRGLGGvDRRFILTQAPSPTTCEDFWHMVWDQECS
 |.|. |.. .    . ..|.      ...|| . .|.  ..|| ||   . |     .||||... |     ..|| ||||  .| |||| |||..|.|
etllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvls...eldgvegsdyinasfidgyqe.rekfiatqaPlentiedfWrmvWeeess

VVVQCHGLVEDGVAVGTRYWPTRTIWHQMPVMTTHGPKKtrkrtiRLNDYKIKLVHEAELDHAIYSriklwkgalgpRTLTHVWMLSTGSKREPQHARTW
.||   .||| .     .|||. ....   .. |   ..      .|.|| |. ..  ..   . .           |...|   ..   .  |..|.. 
ivvmltklveklkvklkkywpeenfeeyGrlivtleeee......eledyiirklklnkkssevet...........RevkhfqyteWpdhdvPekatsl

NTVVRDVAGMRT--GSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTHEN
  ......  |    | |.||||  |. |   |..||.   .. ..|. ||  || .||  | . ..  |||.|.. |   .. . . 
ldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt

subfamily_PTPN14_pd Subfamily PTPN14 707-980 1.2e-29 98.2 In-house 23-292 (300) alignment
Range on Protein: 707-980
Range on HMM: 23-292/300.0
TMLQSEYESIPPNAAS----VDELPSGvESRNRSPSVLPNIHSRVYLSVdmSSDTalRDEYINANYMR-GLGGVDRRFILTQAPSPTTCEDFWHMVWDQE
...  ||| ||.. .     . .||   ...|| . |||  ..|| ||   . ..  ...||||  ..  .|| .| .| .|.| ..|..|||.|||.|.
gkvfteyeripkkredallstaklpen.aeknrfkdvlPyednrvelsp..tken..stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqg

CSVVVQCHGLVEDGVAVGTRYWPTRT------IWHQMPVMTTHGPKKTRKRTIRLndyKIKLVHEAELDHAIYSRIKLWKGALGPRTLTHVwmLSTGskR
 ...|.     |||     .|.|  .       . .  |.|    . ..  |. |   |.| .   |    .. . . |     |. ...   ||    .
vqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittgl...klkhlpskeertvwhlqytDWpdhgvPeDvkgf..lsyL..e

EPQHARTWNTVVRDVagmRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
| |  |   .  ..    .  . ||.|||  |. |  | .  |.|   | .. . |.  .. .||. | | ...| ||.|.. . 
evqsvrrktnseves...keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvl

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 709-985 2.2e-36 120.7 In-house 36-291 (298) alignment
Range on Protein: 709-985
Range on HMM: 36-291/298.0
LQSEYESIPPNAASVDELPSgVESRNRSPSVLPNIHSRVYLSVDMSSDtalRDEYINANYMRGLGGVDrRFILTQAPSPTTCEDFWHMVWDQECSVVVQC
|.|  ..|. .  .| . |.  ...|| .....  .||| |. . . .     .|||| .. .  | .  ||.|||| ..| ||||.||.... ...|  
lnsvsseieeeekevarkpe.nkkkNRyadiialdssRvvLekedade...esdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVml

HGLVEDGVAVGTRYWPT--RTIWHQMPVmtthgpkktrkrtirlndykiKLVHEAELDHAIYSRIKLWKG-ALGPRTLTHVWMLSTGSKREPQHARTWNT
. |.| .    ..|||.   . . .. |                     .| .. |    |  ..|. |    . |.. .. . |  .| .|..|..  .
tnleeldktkyhkywPdegketygeitv.....................sllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvld

VVRDVAGMR--TGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFAR
..|.|  ..  .| .||.|.|  |..|   |.|.| .  .. .. . ||. .|  ||..|   ... ||| |.. |   .  
llrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 709-980 2.7e-33 110.3 In-house 17-272 (281) alignment
Range on Protein: 709-980
Range on HMM: 17-272/281.0
LQSEYESIPP---NAASVDELPSGVESRNRSPSVLPNIHSRVYLSVDmssDTALRDEYINANYMRGLGGvDRRFILTQAPSPTTCEDFWHMVWDQECSVV
...|||..     . ...         .||   .    ..|| .. .   ...   .|||||.. |. | ....| ||.| |.....||.|||.|. |..
fieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpn...eenkntDYinanfvpgykg.ekeyiatqgPvPaslvafWqmvweqkvsai

VQCHGLVEDGVAVGTRYWPTRTiwHqmpvmtthgpkktrkrTIRLNDYKIKLVHEAELDHAIYSRIKLWKGALGPRTLTHVWMLSTGSKREPQHARTWNT
|     .| |     ||||  .  .                .... |...| ..|.|  . |  ..|| .    .|.....  ..   .  |. ..    
vmvtreieagklkChrYWPddn..s................elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkelle

VVRDV--AGMRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQ-GTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
  ..|  .  .   ||.|.||  |. |  ...||| |  .. ..  ..||  .| .||..| | . .. ||.|.. | 
frkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykav

subfamily_PTPRK_pd Subfamily PTPRK 709-980 3.3e-33 109.8 In-house 24-273 (314) alignment
Range on Protein: 709-980
Range on HMM: 24-273/314.0
LQSEYESIPPNAASVDElpSGVESRNRSPSVLPNIHSRVYLSVdMSSDTalRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQC
.. ||||..    .  .     ...|||  .|.  .||| | . .  |.    .||||... .     . || || | . | .||| .|.|..|. .|  
fkeeyeslfegwdaakk..denreknrsgdilaydrsrvflit.idgdp..ssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvydencasivml

HGLVEDGVAVGTRYWPTRTIW-HQMPV--MTTHGPKKTRKRTIRLNDykiklvheaeldhaiysrikLWKGALGPRTLTHVWMLSTGSKREPQHARTWNT
  ||| |    ..|||  |    .. |  . |.  ..  .|. |..                     | .|  . |.. ..  |.  .   |..|..  .
telvevgrvkClkyWPedtevygdikvelvetellaelvvrifrvek....................largqeeirevrqfqflgWpdhdvPvsatgllk

VVRDVAGMRT-GSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
.|| |  ..  .  ..||||  |  |  .|.|.||.   . ..|. ||  .| .||. .   ..  |||.|.. ..
lvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi

subfamily_CG42327_pd Subfamily CG42327 710-827 2.9e-21 70.4 In-house 8-122 (319) alignment
Range on Protein: 710-827
Range on HMM: 8-122/319.0
QSEYESIPPNAASVDELPSGVESRNRSPSVLPNIHSRVYLSVDMSSDtalRDEYINANYMRGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCH
  |.. .|   |. ||.| . . ..|   |.|  ..|| |    . |   .|||..|.|.||    .  .| .|..   .  ||| .||.|   |.||  
aeefrdlPqliaradevPvtskdksrvinvvPlPetrvvlqrigddd...kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

GLVEDGVAVGTRYWPTRT
 | | |. | ..|.||. 
dlselGikvcaeylPtke

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 714-987 1.3e-42 140.7 In-house 2-267 (270) alignment
Range on Protein: 714-987
Range on HMM: 2-267/270.0
ESIPPNAASVDELPSGVESR--NRSPSVLPNIHSRVYLSvDMSSDTalRDEYINANYMRGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGL
. .. ...| ..||. .  .  ||.  .||. ..|| |. ....|   . .||||||.||  | ....| ...| ||| ..|| |.|... . .|   ||
keldkeetsesdlpeaargkklnRyadiLPsPatRvrle.eleeds..ataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgl

VEDGVAVGTRYWPTrtiwhqmpvmtthgpkkTRKRTIRLNDYKIKLVHEAELDHA--IYSRIKLWKGALgPRTLTHVWMLST---GSKREPQHARTWNTV
.|.|     ||||.                  .|....|.| ||| . ..|  .   |  |..| . .   | |.| |. .    |  ||.... . . .
eEkgrkkCerYWpa.................epkekvkledgkikvlalseekeegyiltrlrleekge.errlvHfwyntWpdhgvpreedsslstdql

---VRDVAGMR--TGS-APVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTH
   .|.|  ..  .    |..|||  |..|  ...||||    | ... .|||  . .||.||  ...  |||.||..|  ..|.. 
lkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 715-987 2.4e-23 77.5 In-house 19-269 (283) alignment
Range on Protein: 715-987
Range on HMM: 19-269/283.0
SIPPNAASVDElPSGVESRNRSPSVLPNIHSRVYLSVDMSsdtalrdEYINANYMR--GLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLV
|.|.  | ..   .  .  ||   ..|    || |  .         .|||| ..        |...| .|.|   |  |||.||.|.. . .|    | 
svpdldadias.adenkrknrnqeivpadqwrvelksesr.......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklq

EDGVAVGTRYWPTRTIWHQMPVMTTHGpKKTRKRTIRLNDYKIKLVheaeldhaiysriklwKGALGPRTLTHVWMLST---GSKREPQHARTWNTVVRD
||     ..||| |      .   |   | | ...       ..                    |     |.|  .      | .        .| |.  
edlrikCsqyWPkrGsedyGeftvtlr.kettsnsfiikelllrvn................ssakstlllahyqvidWleygeqaiinslvkfnkvisl

VagMRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTH
    .   .|.||||  || | |||.|.     ..  .   ||  .|  .|..|   . .|.||...| ..   |   
q..teskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcg

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 717-979 7.2e-30 99.2 In-house 36-283 (325) alignment
Range on Protein: 717-979
Range on HMM: 36-283/325.0
PPNAASVDELPSGVeSRNRSPSVLPNIHSRVYLSVDmssDTALRDEYINANYMRGLGGVDrRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLvEDGV
 . |  |  .|  . ..|| . |..  .||| |      . .   .||||.|.|   . |  |. .||| ..| .|.| .| | .|||||    | . | 
dgiakkvamkpenk.aknrfknvvaldksrvvletk...kddpssdyinasylrddkkkd.vflaaqaPltatindlWrlvldWrcsvvvvlnel.dlgk

AVGTRYWPTrtiwhQMPVMTTHGPKKTRKRTIR-LNDYKIKLVHeaeldhaiysrIKL-WKG-ALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAG-
   . |||      .|    | |. . . |||  . ||  . ..           .|   || ..  . . .      | .. |    ..  .|  |   
drcavywpk.....emgksktfGglevklrtieeisdyvhrvld...........vkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavser

MRT---GSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAA
...   .|.|..|||  |. |  ||..|  .  ..|..   |..| | .||.||   ... .|| ... |
vtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyea

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 718-978 1.4e-17 58.7 In-house 30-271 (307) alignment
Range on Protein: 718-978
Range on HMM: 30-271/307.0
PNAASVDELPSGVeSRNRSPSVLPNIHSRVYLSVDmssdtALRDEYINANYMrGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVA
|.. .|. . .    .||   |    ..|. . .|      |  .|| |||. |.    ..|| .| |  .|  .|| |. ...   |.    ..| .  
pegvtveafsant.dknryqdvkcqdkgrivvkfd.....glasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielaki

VGTRYWPTRTiwHQMPVMTthgpkkTRKRTIRLNDYKIKLVHEAElDHAIYSRIKLWKgALGPRTLTHVWMLSTGSKREPQHARtwnTVVRDVAGMRTGS
   .|||      |  |..       . .|| ...  .| .   | |    . .|.   | . ||..|.       .  ||      | .  .  .|   
kceqywplee..gqklvfg......eapntisvanlgakklapde.dlinvttlkvdw.aqksrtiqhlqwenwpdrgvpqinl...tainlleavrydt

APVVVHCPLGIERGAVFVALDILQMQLIQQG-TADVLGTVCQLRQDRGLCINSLEQYRFLHA
 ||||||  |. |    ||. ..| ..|.     |.   | .||..|  .|..  || .|| 
npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhr

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 718-978 9.6e-13 42.8 In-house 29-265 (288) alignment
Range on Protein: 718-978
Range on HMM: 29-265/288.0
PNAASVDELPSGVES--RNRSPSVLPNIHSRVYLSvdmsSDTalrDEYINANYMRgLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDG
|| ||.|   | ...  |.|   .     .|| ||     |.   | ||.|| .   .  .||.| .|||  .| | .|.|. ...   .|    |.| |
pneasidiidsfianptrdryenlprcditrvkls....ddp...dfyiaanvvs.sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekG

VAVGTRYWPTRtIWHQMPVMTThgpkktrkrtirLNDYKIKLvheAELDHAIY-SRIKLWKGALGPRTLTHVWMLSTGSKREPQharTWNTVVRDVAGMR
      |.|.. . ... .                .. | |    |..|. .  | ..  |    .  . .. .|    .  |.    . . .| .  ..
keksaeyfPsk.lGekarigrl............ctvvkkkr...adidklvkvsllriskegeekvivkilhlleWdddgvPe...nylsplrllevlk

TGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHA
.   |.|||.  |. | . ..   |   .|  .    .   . .||..|  .|..  || ..| 
slqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhr

subfamily_PTPRN_pd Subfamily PTPRN 719-826 1.1e-16 55.4 In-house 46-149 (297) alignment
Range on Protein: 719-826
Range on HMM: 46-149/297.0
NAASVDELPsGVESRNRSPSVLPNIHSRVYLSVDMSSDtalRDEYINANYMRGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAV
....| . .  . ..||| .|||  |||| |. . |..   ...||||  .         .| ||.| ..|  ||| |||.| . |.|.   | |.||  
stkevakae.knvkknrskavlpydhsrvklkeeasae...ksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkq

GTRYWPTR
 .||||  
ckrywpde

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 722-827 8.5e-16 52.6 In-house 36-154 (350) alignment
Range on Protein: 722-827
Range on HMM: 36-154/350.0
SVD-ELPSGVE--SRNRSPSVLPNIHSRVYLS-----VDMSSDTALRDEYINANYMRGL-G----GVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQC
| | .| .|||  ..||   .||  |||| |       |    .   ..||||||..          | ..| |||| | | .||....   .  |..  
snDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsl

HGLVEDGVAVGTRYWPTRT
  .|| ..    |||.  .
tsdvelnlekcyrYWqegs

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 724-984 3.9e-17 57.1 In-house 27-259 (267) alignment
Range on Protein: 724-984
Range on HMM: 27-259/267.0
DELPSGVESRNRSPSVLPNIHSRVYLSVDMSSdtalrdeYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAvgtRYW
  ... .. |||   .||  ..|| |.            |||| |. |     . ||.|| |   |  ||. .. ||...|.|  .   .| .    ..|
qsiaeknqernrlddnlpyddtrvilrtkeee.......yinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltkvftdnir...lfw

PTR-TIWHQMPVM-TTHGPKKTRkrtirlNDYKIKLVhEAELDHAIYSRIKLWkgalgprtLTHVWMLSTGSKrePQHARTWNTVVRDvaGMRTGSAPVV
| .    ..   .   |  .|        |||.|  . | ..       . |.          . | . |  |  |     .  . ..   .  |. |.|
PPkmgqakkyqdltvehslekee......ndyqiitl.elkfknesahnvtly........yykkwnintnnk..pylkplfgilakn..qlengnrPlv

VHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFA
|.|  |. |   |. .|    .. ..|..|.   . ..|. |   ....|.| ..|     .|
vacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 724-824 3.7e-13 43.5 In-house 40-154 (349) alignment
Range on Protein: 724-824
Range on HMM: 40-154/349.0
DELPSGVES--RNRSPSVLPNIHSRVYLSVDM-----------SSDTALRDEYINANYMRG-LGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCH
 .| .|||.  .||   .||  |||| |   .            ||..  |.||||||..     |....| ||||.|.| .||....  ..  .|.   
vilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLn

GLVEDGVAVGTRYWP
   | ..    .|| 
ddkelslekcdiywq

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 724-824 4e-08 27.2 In-house 90-179 (244) alignment
Range on Protein: 724-824
Range on HMM: 90-179/244.0
DELPSGVESRNRSPSVLPNIHSRVYLSvdmssDTALRDEYINANYMRGLGGVdRRFILTQAPSPTTCEDFWHMVWDQECSVVVQcHGLVEDGvavgTRYW
| .      .||  . ||   .|| ||       .. . |||| ..  ||     .|||| |   |  |||.|. ..   |.|   | ||.       ||
dafnpnnswknregaglpfdfnrvpls.....kgsmgntyinasfvgclgrt.aeyiltqhpladtsmdfwkmmlerhvnvlvv.lgsveee....deyw

P
|
p

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 725-808 7.9e-08 26.2 In-house 33-116 (347) alignment
Range on Protein: 725-808
Range on HMM: 33-116/347.0
ELPSGVeSRNRSPSVLPNIHSRVYLSVDMS--SDTALRDEYINANYMRgLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQC
|    . |.|||  |  .  .|| || . |  | .   . |||| ... .   .. .|||| | | |  |||.||     . ||  
eweksl.sknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_PTPRB_pd Subfamily PTPRB 726-988 4.1e-43 142.5 In-house 47-289 (293) alignment
Range on Protein: 726-988
Range on HMM: 47-289/293.0
LPSGVESRNRSPSVLPNIHSRVYLSvdmSSDTALRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPT
  .  ...||   .||  |||| |.   . ..   ..||||||..|.    | || || | |.| .|||.|||....|..|    ||| |     .|||.
elavnraknrytnilpydhsrvkLa...alkdesgsDYinanyipgyn.sprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPa

RtiwhqmpvmtthgpkktrKRTIRLNDYKIKLVHEAELDHAIYSRIKLWKgALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMR---TGSAPVVV
                   ....   | |..||.| ||.. .   .|. | .   |....   .|      |....|  . || |  .    . ..|.||
d..................eepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivv

HCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTHE
||  |. |  .|.||| |  .. .. . |..|.|..||..| | . . .|| |.| .  .. |..|
hCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 728-984 2.2e-26 87.4 In-house 44-283 (290) alignment
Range on Protein: 728-984
Range on HMM: 44-283/290.0
SGVESRNRSPSVLPNIHSRVYLSvDMSSDTALRDEYINANYMRGLGGvDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRT
|  . .||.  ....   |. |  ..|..    .||||| |. |    ....|.||.| . |  |||...|.......|     .|.|  .   |||.. 
ssnkllnRfanivvyddnritLr.pisghkDCtneyinAcyikgyke.kkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsd

IWHQMPVMTTHgpkktrkrtirlndykiklVHEAELDHAIYSRIKLWKGAL--GPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAG--MRTGSAPVVVH
  .  ..  .                    ..| .|.. |  .... .      ....|.  . .  |. . ..  |  .|.. .     ..|  ..|||
tkaygefsikl...................lneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvH

CPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFA
|  .. | |||.|...   .  ..|  ||.  . ..|. .   ... .||....    |  
CSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl

DSPc_SM00195 730-982 9.4e-48 158.2 In-house 27-260 (263) alignment
Range on Protein: 730-982
Range on HMM: 27-260/263.0
VeSRNRSPSVLPNIHSRVYLSVDMSSdtaLRDEYINANYMRGLgGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTiw
. |.||.  .||. |.|| |. . ..     ..||||||..|    ....|.||.| |.|.||||.|||.......|     .|.|    .||||     
k.sknRyknilpydhtrVklkkeekk...egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees..

hqmpvmtthgpkktrKRTIRLNDYKIKLVHEAELD-HAIYSRIKLWKGA-LGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRT-GSAPVVVHCPL
               ... . .....|||.. . . . |   ..| | .   .|..|.... .   .  |....    ..| |   .   |.|.||||  
...............ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsa

GIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWT
|..| ..||..||.  .| .. . |.  .|..||. |  ....||||.|.. |.  
GvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

PTPc_SM00194 730-982 9.4e-48 158.2 In-house 27-260 (263) alignment
Range on Protein: 730-982
Range on HMM: 27-260/263.0
VeSRNRSPSVLPNIHSRVYLSVDMSSdtaLRDEYINANYMRGLgGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTiw
. |.||.  .||. |.|| |. . ..     ..||||||..|    ....|.||.| |.|.||||.|||.......|     .|.|    .||||     
k.sknRyknilpydhtrVklkkeekk...egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees..

hqmpvmtthgpkktrKRTIRLNDYKIKLVHEAELD-HAIYSRIKLWKGA-LGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRT-GSAPVVVHCPL
               ... . .....|||.. . . . |   ..| | .   .|..|.... .   .  |....    ..| |   .   |.|.||||  
...............ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsa

GIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWT
|..| ..||..||.  .| .. . |.  .|..||. |  ....||||.|.. |.  
GvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 730-983 7.3e-23 76.0 In-house 47-277 (287) alignment
Range on Protein: 730-983
Range on HMM: 47-277/287.0
VESRNRSPSVLPNIHSRVYLSvdmssdtALRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTrtiw
 . .||.  .|.    || |          ...|||| .. |    ...||....|   |  .||....|.. ...|    . |.   |  .|||.    
nkdknRltqilvpdnyrvllk.......gehpdyinavfidgyk.ekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpe....

hqmpvmtthgpkktrKRTIRLNDYKIKLVHEAELDHAIYSRIKLWKGA--LGPRTLTHVWMLSTGSKREPQHARTWNTVVRDV--AGMRTGSAPVVVHCP
               .... | .|.|.|..|   .. |  .... .      .....   . .  |... .. .|   |. .   .  . | ...|||| 
...............eksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCs

LGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTF
 .. | |.|.| ..   .  ..|. ||.  . . |. .   .   |||.|.  .  ..
dtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivley

subfamily_ptpA1_pd Subfamily ptpA1 730-836 4.9e-16 53.5 In-house 47-148 (418) alignment
Range on Protein: 730-836
Range on HMM: 47-148/418.0
VESRNRSPSVLPNIHSRVYLSVDMSSDtalRDEYINANYMRGlgGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIW
  |.||   .||  |.|| |      .     .||||||. |     ..|| || | | |  |||.|||.. | ..|      |.      |||| .   
ntsknrytnilpvnhtrvqlkkiqdke...gsdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigg

HQMPVMT
 |. .  
eqfsiyg

0046845 (Phosphotyrosine protein) phosphatases II 731-987 9.7e-53 174.7 In-house 29-277 (284) alignment
Range on Protein: 731-987
Range on HMM: 29-277/284.0
ESRNRSPSVLPNIHSRVYLSVDMSSdtALRDEYINANYMRGLG----GVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTR
 |.||....||. ||||.|..  ..     ..||||.|..| .     . ..||.||.| |.|.||||.|||.|...|.|   .|||.|.    .|||. 
lsknRykdilpydhsRVklksldgd..ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple

TIWHQMpvmtthgpkktrkrtirlNDYKIKLVHEAELDHAIYSRIKLWKG--ALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRTG---SAPVV
  . ..                  .|....|..| . |. .. ...| .      .||.|| ...|      |....   . .|.|  ...    . |.|
gevlty..................gdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpiv

VHCPLGIERGAVFVALDILQMQLIQQG---TADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTH
|||  |. | ..|.|||.|  ||...|   . |||..|..||. |  ....||||||.. |.. .....
VHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk

0045098 (Phosphotyrosine protein) phosphatases II 731-983 9.4e-46 151.8 In-house 34-271 (278) alignment
Range on Protein: 731-983
Range on HMM: 34-271/278.0
ESRNRSPSVLPNIHSRVYlsvdmssdtalrdEYINANYMRGLggvDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIWH
 ..|| ...||. ||||.             .||||.|..|    ...||.||.| |.|..|||.|.|.. ..|.| . .|||.|.    .||| .  . 
ldknRykdilpydhsrVk.............dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslt

QmpvmtthgpkktrkrtirlNDYKIKLVHEAELDHAIYSRIKLWK-----GALGPRTLTHVWMLSTGSKREPQHA--RTWNTVVRDVAGMRT--------
                    .|....|. | .||. .. .....        | .|..||...|.      | .   . .  ... .   .         
y...................gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasllls

------GSAPVVVHCPLGIERGAVFVALDILQMQLiqQGTADVLGTVCQLRQDRGL-CINSLEQYRFLHAAAWTF
      .. ||.|||  |. | ...||....  .|  .|. |.| .|..||. |.  .. .|||||||. ..  .
slllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllel

0045450 (Phosphotyrosine protein) phosphatases II 731-981 2.8e-45 150.7 In-house 56-301 (307) alignment
Range on Protein: 731-981
Range on HMM: 56-301/307.0
ESRNRSPSVLPNIHSRVYLSVDMSSdtALRDEYINANYM--------RGLGGvDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRY
 ..||....||. |.||.||.  .|     . ||||.|.         |    .|.||.||.| | |.||||.|.|.| ..|.| . .|||.|     .|
kdknrykdilpydhtRVklssldgs..ledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqy

WPTRTIWHQMPvmtthgpkktrkrtirlnDYKIKLVHEAELDHAIYSRIKLWK--GALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRT---GS
||.   . .                    .....|. | .||. .. .....   |   .||.|| ....      |..  .    .. |  ..    ..
wPdegeeltyg..................nftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkg

APVVVHCPLGIERGAVFVALDILQMQLIQQGT---ADVLGTVCQLRQDRGLCINSLEQYRFLHAAAW
 ||.|||  |. | ..|.|....  || ..||    |.| .|..||. |. .. ..||||||. |. 
gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall

subfamily_PTPN23_pd Subfamily PTPN23 731-991 7.9e-33 108.5 In-house 44-287 (288) alignment
Range on Protein: 731-991
Range on HMM: 44-287/288.0
ESRNRSPSVLPNIHSRVYLSvdmssdtALRDEYINANYMRGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTiwh
 ..|||  .||  |.|| |          .|.|||| ....|  .   || |||| ..|  ||| ||..|  ||.|  .   | |     ||||...   
seknrsrdilPyDhnRvklr.......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedk...

qmPVMTTHGPkktrkrtirlndYKIKLVHEAELDHAIYSRIKLW-KGALGPRTLTHVWMLSTGSKREPQ---HARTWNTVVRD--VAGMRTGSAPVVVHC
     ...|.            ... | .. |... .   .||  ..|   ....|. . |  .   |.   .   .  .|..   |  |   .|.||||
..getvkfgd............lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhC

PLGIERGAVFVA-LDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTHENQL
  |..|  ||     ...    ..| .|..  | .||..|   ..  ||..|.  |  . ||   .. 
saGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvldkr

subfamily_PTPN6_pd Subfamily PTPN6 731-988 1.3e-29 98.2 In-house 55-301 (306) alignment
Range on Protein: 731-988
Range on HMM: 55-301/306.0
ESRNRSPSVLPNIHSRVYLSvdmsSDTALRDEYINANYMR-GLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIW
...||  ..||  |.|| |.    ..    ..||||||..  . | |...| ||   .|| .|||.|||.... |.|     || |    .||||. .  
keknryknilPfDhtrvilk....epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeek

HQMPVMTTHGPKKTRKRTIRLNDYKIKLVHEAELDHAIY-SRIKLWKGALGPRTLTHVWMLSTGSKREPQHARtwntvvrdvagmRTGSAPVVVHCPLGI
... ... .  .......  | . ... .....  . ..  . | |  .  |.   .|  . .  .|. .. .            .. . |.||||  ||
eeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeele............eaeagpivvhCsaGi

ERGAVFVALDILQMQLIQQGT---ADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTHE
 |   |. .|||  .. ..|.    |.  .| ..|. |   ..  .||.|.. |  .. .|..
GRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk

subfamily_CG7180_pd Subfamily CG7180 731-977 1.7e-26 87.6 In-house 43-283 (296) alignment
Range on Protein: 731-977
Range on HMM: 43-283/296.0
ESRNRSPSVLPNIHSRVYLSvdmSSDTALRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVaVGTRYWPTRTI--
  .|| . |.|  . ||.|.   . |   ...|||| |. ..   .. .| |.||   | ..|| .|.|.|.| ||      .        ||| ..   
reknrdvkvvPyDynRvvLe...kldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeq

WHQMPV--MTTHGPKKTRKRTIRLNDYkIKLVHEAELDHAIYSRIKLwKGALGPRTLTHVWMLSTGS-KREPQHARTWNTVVrdvaGMRTGSAPVVVHCP
. .. |  ....   . ..||..|.   |  . | | .  .  || . .  |    | .   ||| .     . .|.|   |      .   .||||...
ygeifveiveekqyanlkirtfkltkk.ivalteqekqvkaetRivk.lfqlteWeledkvPlstnalielrrrvrlwrekv....dedpeegPvvvvss

LGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLH
 |  |  |..|.|.   ......  || . | .||..|   ... |.|... 
dGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiY

subfamily_PTPN1_pd Subfamily PTPN1 731-979 5.1e-26 86.0 In-house 33-266 (290) alignment
Range on Protein: 731-979
Range on HMM: 33-266/290.0
ESRNRSPSVLPNIHSRVYLSVDMSsdtalrdEYINANYMRgLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIwh
 ..||   | |  |||. |  .         .||||. .  |  ..|..|||| | | |.. ||.|||.|..  ||    .|| .    ..|||.     
rnlnryrdvspydhsrikleradn.......dyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee..

qmpvmtthgpK--------KTRKRTIRLNDYKIKLVHEAELDHaiysriklwKGALGPRTLTHVWMLS---TGSKREPQHARTWNTVVRDVAGMRTGSAP
          .        | . . |. ....   |.  ||.          . .   |...|   ..    |  . |.    .   ||.   . .   |
..........ekellledtklkvkliseerksyytvrllelen.........lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGp

VVVHCPLGIERGAVFVALDILQMQLIQQGT---ADVLGTVCQLRQDRGLCINSLEQYRFLHAA
.|.||  || |   |. .| . ... ...     |.  ....||. |   |   .| || . |
avihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsyla

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 731-987 3.8e-25 83.2 In-house 39-280 (287) alignment
Range on Protein: 731-987
Range on HMM: 39-280/287.0
ESRNRSPSVLPNIHSRVYLSvdmsSDTALRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRtiwh
 ..||   |||  ..|| ||     .. |  .||||||. .    | .|| .|.| ..|  ||| .|.... ..|.     ||..     .||| |    
vkknryadvlPiddtrvlls....aegelGsdyinanyvasyt.ddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer....

QMPVMTThGP-KKTRKRTIRLNDYKIKLVHEAELDHA---IYSRIKLWKGALGPRTLTHVwmlstGSKREPQHARTWNTVVRDVagmrTGSAPVVVHCPL
..|..   |      ...|.  .| .. .  ..|.     .  ...| .   .  . | |     |  |     .    . ||     ..  |.|||.  
evPmrvG.GysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtav.....glirfvldvkqhielarda....sevGPlvvhddv

GIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTH
|| |  ...|. .|  .| . |  ||  .| .||. |   ...  |.|.|  |  |. .| 
GiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 731-979 9e-24 78.9 In-house 45-272 (315) alignment
Range on Protein: 731-979
Range on HMM: 45-272/315.0
ESRNRSPSVLPNIHSRVYLSVdmsSDTALRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRtiwh
 ..||   .||  ..|| | |    |    ..|||| |....   |. .| .|.| ... .|||.||.... . .|    . |.      .||| |    
fkknryknilPldsarvklev...iddsPdsdyinasyiksvd.ddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr....

qmpvmtthgpkktRKRTIRLNDYKIKLVHEAELDHAIYSRIKLWKGAlGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGM-RTGSAPVVVHCPLGIE
             .  ....  .|..|.       ..  .. . |.    ||.|   .     |  .... .   ....| .  ..   ...|||  |. 
.............kadsvefGsikvellsleadtdgvarklvtrkse.esrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvG

RGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAA
|  |....|    |. .. . ||. .| .||..|   ... |.| |.. |
rtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiyda

0049772 (Phosphotyrosine protein) phosphatases II 731-985 2.5e-22 75.5 In-house 47-281 (314) alignment
Range on Protein: 731-985
Range on HMM: 47-281/314.0
ESRNRSPSVLPNIhSRVYLSvDMSSDTalrDEYINANYMRGLggvdRRFILTQAPSPTTCEDF----------WHMV--WDQECSVVVQ-----------
 ..||.. .||   .|| |.  .. ..     ||||.|..|     ..|| ||.|.. |..||          |.||  .|. . ..|            
rdknryldilpad.nrvilp.glpvsg...sdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------CHGLVEDGvavgtRYWPTRTIWHQMpvmtthgpkktrkrtirlndykiklvheaeldhaI-------YsriklwkgalgPRT-LTHVWMl
            .| . |      ... ... .                                            .           .|. ...... 
rLdaAlgKtpllildgng.....neptaadlellk..................................eelydpelf...........erlgikylri.

STGSKREPqHARTWNTVVRDVAGMrTGSAPVVVHCPLGIERGAVFVALDILQMQLiqqGTaDVLGTVCQLRQDRG-----LCINSLEQYRFLHAAAWTFA
 .    .|   . .. ... .        ||.|||  |. | ..||....| ..|   |  ..  .. ..|. |       .|..|||| | . |   . 
pvpDgsap.lledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleyl

R
.
k

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 731-980 6.3e-21 69.2 In-house 46-232 (392) alignment
Range on Protein: 731-980
Range on HMM: 46-232/392.0
ESRNRSPSVLPNIHSRVYLSVdmsSDTALRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGvavgtrywptrtiwh
  .||   .||   .|| | |    |    ..|.|| |....   .. .| .|.| ... .|||.||.... . ..    | |                 
lkknryknilpydsarvklev...iddipdsdylnasyipsfd.nekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...............

qmpvmtthgpkktrkrtirlndykiklvheaeldhaiysriklwKGAlGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRTG-SAPVVVHCPLGIE
                                            ||    || .   .     |  |.|. .   ....|       . |...||  |. 
............................................kgd.dartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvg

RGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
| .| ...| .  .  .    ||.  | ..|. |   ... ||| |...| 
rtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav

0040438 (Phosphotyrosine protein) phosphatases II 732-986 2.7e-47 157.0 In-house 45-278 (317) alignment
Range on Protein: 732-986
Range on HMM: 45-278/317.0
SRNRSPSVLPNIHSRVYLSVdmsSDTALRDEYINANYMRGlGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTrtiwhq
..||.|..||. ||||.||.    .  | . ||||.|. |     |.||.||.| | |.||||.|||.| ..|.|    |.|.|.    .|||.      
dknrypdilpydhsRVkLsp...lggdldsdYInAsyvdg.pnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl......

M-----PvmtthgpkktrkrtirlnDYKIKLVHEAELDHAIYSRIKLWK-GALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRTG-SAPVVVHC
                         |....|. | ||.. .. ...... |   .||.|| ....      |.. ..    .. |   . . . ||.|||
getltyg..................dftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHC

PLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFART
  |. | ..|.|.... .|| . |. ||  .|..||. |. .. ..||||||. |.  . ..
saGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr

Y_phosphatase Protein-tyrosine phosphatase 732-979 1.8e-46 153.9 Pfam-A 3-232 (235) alignment
Range on Protein: 732-979
Range on HMM: 3-232/235.0
SRNRSPSVLPNIHSRVYLsvdmsSDTAL-RDeYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWP----TR
..||....||  ..|| |     ...    | ||||||..|    ...||.||.| . |.||||.|||.....|.|.   |.| |     .|||    . 
kknRykdilpydktrvkl.....kgsegpsd.YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

TIWHQMPVMTThGPKKTRKRTIRLNDYKIKLVHEAEldhaiysriklwkgalGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMR-TGSAPVVVHCP
.  ... | ..   .|. .  . |.....|   | .                 .|....... .   .  |....    ..|.|   . . |.|||||| 
ltygdikvelk.ekekedekeytlrklelkkkkees................ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCs

LGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAA
 |..| ..||||||| .|| .... ||| .|..||. |  ...||||| ||..|
aGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyka

Y_phosphatase Protein-tyrosine phosphatase 732-979 1.8e-46 153.9 In-house 3-232 (235) alignment
Range on Protein: 732-979
Range on HMM: 3-232/235.0
SRNRSPSVLPNIHSRVYLsvdmsSDTAL-RDeYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWP----TR
..||....||  ..|| |     ...    | ||||||..|    ...||.||.| . |.||||.|||.....|.|.   |.| |     .|||    . 
kknRykdilpydktrvkl.....kgsegpsd.YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

TIWHQMPVMTThGPKKTRKRTIRLNDYKIKLVHEAEldhaiysriklwkgalGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMR-TGSAPVVVHCP
.  ... | ..   .|. .  . |.....|   | .                 .|....... .   .  |....    ..|.|   . . |.|||||| 
ltygdikvelk.ekekedekeytlrklelkkkkees................ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCs

LGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAA
 |..| ..||||||| .|| .... ||| .|..||. |  ...||||| ||..|
aGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyka

0043336 (Phosphotyrosine protein) phosphatases II 732-981 8.2e-44 145.5 In-house 47-274 (278) alignment
Range on Protein: 732-981
Range on HMM: 47-274/278.0
SRNRSPSVLPNIHSRVYLSVDmssDTALRDEYINANYMRGlGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPtrtiwhq
..||....||. ||||.||..   .  | . ||||.|. |   | |.||.||.|.| |.||||.|||.. ....|   .|||.|.    .|||       
dknrykdilpydhsrvklsll...ggdldsdYinAsyvdg.ynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.......

mpvmtthgpkktrKRTIRLNDYKIKLVHEAELDHAIYSRIKLWK-GALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRT-GSAPVVVHCPLGIE
             . ... .|....|. | .||. .   ..... |   .|| ||.. |.      | .  .    ...|  ..   . ||.|||  |. 
.............ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvg

RGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAW
| ..|.||..| .||   |. |.. .|..||. |. .. ...|||||. |. 
RTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall

0040439 (Phosphotyrosine protein) phosphatases II 732-980 3.9e-41 136.7 In-house 13-242 (249) alignment
Range on Protein: 732-980
Range on HMM: 13-242/249.0
SRNRSPSVLPNIHSRVYLSVDMSsdtALRDEYINANYMrGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPtrtiwhq
..||.|..||. ||||.||.  .      . ||||.|.  .  . ||||.||.| | |.||||.|.|.. ..|.| .  ||| |     .|||       
dknrypdilpydhsrvklsilpg...lflsdyinAsyi.dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp.......

mpvmtthgpkkTrKRTIRLNDYKIKLVHEAELDHAIYSRIKLWK-GALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRT---GSAPVVVHCPLG
           . . ..  .|....|... ..|. .   ..|.. .   .|| .|.....      |..  .    .. |  ...    . ||.|||  |
...........l.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaG

IERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
. | ..|.|.... .||   .. |.. .|..||. |. .. ..||||||. |.
vgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeal

0042113 (Phosphotyrosine protein) phosphatases II 732-980 9.5e-40 131.9 In-house 11-239 (245) alignment
Range on Protein: 732-980
Range on HMM: 11-239/245.0
SRNRSPSVLPNIHSRVYLSVdmsSDTALRDEYINANYMrGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTrtiwH-
..||....||. |.||.||.    .. | . ||||.|. ..  . ..||.||.|.| |.||||.|.|.. ....| .  ..|.|     .|||.    . 
dknrysdilpydhtrvklsp...dggdldsdyinasyv.dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl....ge

---QmpvmtthgpkktrkrtirlNDYKIKLVHEAELDHAIYSRIKLWK-GALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRT--GSAPVVVHC
                       .|....|. |  ||. .   ..... |   .|. .|.. |.     .| . ..   ... |   .   .. ||.|||
slty...................gdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHC

PLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
  |. | ..|.|.... .||   .. ..  .| .||. |. .. ...|||||. |.
saGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal

0037934 (Phosphotyrosine protein) phosphatases II 732-979 4.3e-37 123.4 In-house 12-237 (243) alignment
Range on Protein: 732-979
Range on HMM: 12-237/243.0
SRNRSPSVLPNIHSRVYLsvdmsSDtalrDEYINANYMRGLGgvdrRFILTQAPSPTTCED----FWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPtrt
|.|| ...||. ||||.|     ..    . |||||......    |.|.||.| | |.||    ||.|.|.. ..|.| .  ||| |.    .|||   
sknrysdilpydhsrvkl.....eg....sdyinanliyvtp....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...

iwhqmpvmtthgpkktrkRTIRLNDYKIKLVHEAELDHAIYSRIKLWK--GALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAG---------MRTG
                   ... .|....|..| .||. ..  ..|.       .|. .|.. |.      |..       ...|            . .
..................gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllalds

SAPVVVHCPLGIERGAVFVALDILQMQLiqqgTADVLGTVCQLRQDRGL-CINSLEQYRFLHAA
. ||.|||  |. | ....|.... ..|    . |.. .|..||. |.  .. ...|||||. |
ggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyea

subfamily_PTPRG_pd Subfamily PTPRG 732-992 1.1e-36 121.2 In-house 49-295 (563) alignment
Range on Protein: 732-992
Range on HMM: 49-295/563.0
SRNRSPSVLPNIHSRVYLSVDMSSDTALrdEYINANYMRGLGGvDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIwHQ
 .||  ....  .||| ||     .  |  .||||||. |     . || || |...|..|||.|.|.|. ...|    |||.|     .|||. .   .
rKnRylnivaydrsRvklsplpgkkkkl..DYinAnyidGyqk.skafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdes.et

MPVMTTHGPKKTRKRTIRLNDYKIKLVHEAELDHaiysriklwkgALGPRTLTHVWMLSTGSKREPQHAR-TWNTVVRDVAGMRTGSAPVVVHCPLGIER
. ...    .. .. .   .  .|| ..  . ..           .   .. ..  . .   .  |.|.    . |... |  ..   |.||||  |. |
ygalqvtlieeevlalytvrtlviknlklkkkkq...........cdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgr

GAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTHENQLG
  ....|| |  |. |. . .|.|.. ..|  |   ... ||| ||| |     ...|..| 
tGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketell

subfamily_PTPN9_pd Subfamily PTPN9 732-987 9.8e-36 118.3 In-house 44-293 (297) alignment
Range on Protein: 732-987
Range on HMM: 44-293/297.0
SRNRSPSVLPNIHSRVYLSVDMSSDtalRDEYINANYMRGLGGvDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWP-TRTIWH
..||   ||   ..|| |.     .     .|||||.. |     . || || | . |..||| |||.||. |.|    .|| |    ..||| ..   .
eknrytdvlcydetrvvlakvdede...asdyinanfvdGykq.kkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessa

QMPVMTTHGPKKTRKRTIRLNDYKIKLVHEAELDHAIYSRIKLWKGALGPRTLTHVWMLStGSKREPQhARTWNTVVRDVAGmRTGSAPVVVHCPLGIER
.   .. .  .   ..  . . ..|| |.. |  . .. ..  |     |.. . .  .     || | | . ...  . .| ..   |.||||  || |
efgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvl.ekvrekq.alavkelgdewkg.hpsgPPivvhcsaGiGr

GAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTH
   |..|||   .| ..||.||  || .||. |   |   ||| | . |   .| ..
tGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalel

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 732-986 7e-30 99.0 In-house 11-244 (250) alignment
Range on Protein: 732-986
Range on HMM: 11-244/250.0
SRNRSPSVLPNIHSRVYLSVDMsSDT-AlrdEYINANYMRGLGGVdRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAvGTRYWPTR--TI
 .||   ...  .||| |  .  .|  .   .|||| .. |  .  . || ||.| ..| |||| ||.... ...|    |.| .    ..|||.   ..
eknryadiialdssrvvLekek.gdkes...dyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaek

WHQMPVMTtHgpkktrkRTIRLNDYKIK---LVHEAELDHaiysriklwkgalgpRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGM--RTGSAPVVVH
. .. |   .        .    ||...   | .. . |.               |.. ..  ..   |  |..|..   ....|     ..|.|||.|.
yGdvtvsl.l.......skeefadytkrklklskakkade...............rivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivq

CPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFART
|  |. |   |.|.| .  .| .. . ||   . .||.||   ..||||| |.. ..  .  .
CsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds

subfamily_PTPN13_pd Subfamily PTPN13 732-980 8.9e-30 98.9 In-house 39-265 (273) alignment
Range on Protein: 732-980
Range on HMM: 39-265/273.0
SRNRSPSVLPNIHSRVYLSVDMSsdtalrdeYINANYMRGLGGVDR-RFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTiwh
..||   |||  ..|| |. . .        ||||....   | |. ..|..| | |.|..||| |||.|...|..     .|.|     |||| ..   
dknryrnvlPydetrvklgdegg........yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesk...

qmpvmtthgpkktRKRTIRLNDYKIKLVHEAELDHAIYSRIKLWKGALG-PRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRTGSAPVVVHCPLGIE
             .|..   | ....|..  .||    ..... . . |  | ..|. . .      |..|    ..|. |. ..| ..|.||||  || 
.............nkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiG

RGAVFVALDILqMQLI-QQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
|  .....|.. ..|| ..   ||  .| .||. |   . . .|| | . |.
rsGtlitidvv.lglierdkefdvkeivrklreqrqgvvqtkdqyifvykai

subfamily_PTPN12_pd Subfamily PTPN12 732-985 7.3e-29 95.5 In-house 42-278 (290) alignment
Range on Protein: 732-985
Range on HMM: 42-278/290.0
SRNRSPSVLPNIHSRVYLSVDMSSDtalRDEYINANYMRGLGGvDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTiwhq
 .||   .||  .||| || . ...    ..|||||...|  | . ..| .|.| |.| .|||.|.|... ..||    .|| |     |||| ..    
kknrykDilPydksrvelskieeee...gsdYinanfikgveg.kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeeg....

mpvmtthgpkktrKRTIRLNDYKIKLVHEAELDHAIYSRIKLWKGALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMR-TGSAPVVVHCPLGIER
             ..... ......| .|  .|. .  |    .     |...     .   .  |. | .   ....|  .. . .||.||||  |. |
.............eeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGr

GAVFVALDILQMQLIQQGT---ADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFAR
  . .|.|. ...| .. .    ||   | .||..|   . . |||.... |   . .
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

subfamily_PTPN3_pd Subfamily PTPN3 732-978 8.7e-29 95.3 In-house 43-269 (280) alignment
Range on Protein: 732-978
Range on HMM: 43-269/280.0
SRNRSPSVLPNIHSRVYLSvdmSSDTalrdEYINANYMR--GLG-GVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRti
|.||   .||  . || |.   .|.|    .||||||.     . |.  |.| || | ..|..|||.|||.|..|..|    |||.|     .|||.   
sknryrdilpydatrvklk...eset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPet..

whqmpvmtthgpkktrKRTIRLNDYKIKLVHEAELDHAIYSRIKLWKGA-LGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRTG-SAPVVVHCPL
                . .... ....|. .|.|    ..  . | . .    |.....  |.   .  |...  . ..|. |  .|.| . ||||||  
................edeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsa

GIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHA
||.|  |...|..  . . ..    .|  | ..|. |.  ... .||.|.  
GigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCe

0041856 (Phosphotyrosine protein) phosphatases II 732-984 1.6e-25 85.1 In-house 3-171 (182) alignment
Range on Protein: 732-984
Range on HMM: 3-171/182.0
SRNRSPSVLPNIHSRvylsvdmssdtalRDEYINANYMRGLGGVDRrFILTQAPSPTTCEDFWHMVWDQECSVVVQCHglvedgvavGTRYWPtrtiwhq
..|| . .||. |||                |||||...|    .| ||.||.| . |..||..|.... ....| .          . .|||       
dknrysdilpydhsr.............dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp.......

mpvmtthgpkktrkrtirlN-DykiklvheaeldhaiysriklwkgalgPRTLTHVWMLSTGSKREPQhartWNTVVRDVAGMRTGSAPVVVHCPLGIER
                   .                             .|. .... |.      |     ...... .  ..  . ||.|||  |. |
...................ell...........................erlgiqylylpwpDhgvpd....ldelldfieevleeggpvlVHCsaGvgR

GAVFVALDILQMQliqqgTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFA
 ...||....  .       ..  .|...|. |  .. ...||.||. |.. . 
tgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallell

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 732-979 5.1e-25 82.5 In-house 45-271 (515) alignment
Range on Protein: 732-979
Range on HMM: 45-271/515.0
SRNRSPSVLPNIHSRVYLSVDmssDTALRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRtiwhq
..||   .||   .|| | |    . .   .|.|| |....   |. .| .|.| ... .|||..|.... . ..    | |.     ..||| .     
kknryknilPydsvrvklevi...ndnPhsdyfnasyipsfd.ndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdk.....

mPvmtthgpkktrKRTIRLNDYKIKLVHEAELDHAIYSRIKLWKGALgPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGM-RTGSAPVVVHCPLGIER
 |             ....  .|..||       .|  .... ||    ||.|   .     |  |.|...   ....|       . |...||  |. |
.p...........gdsvkfGsikvelvsleactggikrkltvlkgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGr

GAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAA
  |....|    .  .  . ||. .| ..||.|   .   ||| |.. |
tGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiyga

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 732-980 1.3e-24 82.1 In-house 63-287 (319) alignment
Range on Protein: 732-980
Range on HMM: 63-287/319.0
SRNRSPSVLPNIHSRVYLSVDMSSDTalrDEYINANYMRGLGGVDrRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHglvedgvavgtrywptrtiwhq
 .||   .|.  ...| |      .     .|||| .. |    | ..| .| | . | .||| |.|...|| .|                         
dknriinilafdknvvklerliGeef...sdyinasfvtGyqrkd.kyiaaqGPldntladfWrmiweyncstivllt......................

MPVMTTHGPKKTRKRTIRlNDYKIKLVHEAELdHAIySRIKLWK--GALGPRTLTHVWMLSTGSKREPQHARTWNTVVRD---VAGMRTGSAPVVVHCPL
    . . |.|. ..  |  . |...|.|..  ...   |.| .     . | .|   .|    .  |...    ..|.    .     . |..||||  
kdkcsqywplkivikeer.fkvkvdsveetae.yvv.rdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsa

GIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
|. |  |...||.|  .. ..   ||  .| .|||.|   ...| || |...| 
GvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 732-979 2.5e-22 74.2 In-house 9-235 (239) alignment
Range on Protein: 732-979
Range on HMM: 9-235/239.0
SRNRSPSVLPNIHSRVYLSvDMSSDTalRDEYINANYMRGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIWHQ
..||   ..   |||| |   .| |   . .||||.|.|   |  . .| ||    ... |||.|.|..   |.|   ||.|       .|||  |  . 
aknryanivtydhsrvvle.klsndp..hsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

MPvmtthgpKKTRKRTIRLNDYKIKLVHEAELDHAiysriklwkgalGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAG-MRTGSAPVVVHCPLGIER
         . | ..|  . || |. .  ... ..              | . .  .     |  ||.| .   . | ..     |. | |.||  |. |
nl.......rvtlrktevfadyiirtfvmsqvgqt............eeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgr

GAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAA
   |. .| .  |  .| | |..  |  .|.||   ... ||| |.| |
tgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 732-979 2.6e-22 74.2 In-house 10-236 (239) alignment
Range on Protein: 732-979
Range on HMM: 10-236/239.0
SRNRSPSVLPNIHSRVYLSvDMSSDTalRDEYINANYMRGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIWHQ
..||   ..   |||| |   .| |   . .||||.|.|   |  . .| ||    ... |||.|.|..   |.|   ||.|       .|||  |  . 
aknryanivtydhsrvvle.klsndp..hsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

MPvmtthgpKKTRKRTIRLNDYKIKLVHEAELDHAiysriklwkgalGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAG-MRTGSAPVVVHCPLGIER
         . | ..|  . || |. .  ... ..              | . .  .     |  ||.| .   . | ..     |. | |.||  |. |
nl.......rvtlrktevfadyiirtfvmsqvgqt............eeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgr

GAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAA
   |. .| .  |  .| | |..  |  .|.||   ... ||| |.| |
tgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 732-979 7e-22 72.5 In-house 50-274 (439) alignment
Range on Protein: 732-979
Range on HMM: 50-274/439.0
SRNRSPSVLPNIHSRVYLSvdmSSDTALRDEYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVavgtrYWPTRTIWHQ
..||  .| .  |.|| |             ||||||..|    |. .| ||.|.  |..||| .|... .. .|.   |||        |||. .    
tknrykdvgafdhtrvtlq...eipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcy

MPVMTthgpkkTRKRTIRLNDYKIKLVHeaeldhaIYSRI-KLWKgalgPRTLTHVWMLSTGSKREPQHARTWNTVVRDV--AGMRTGSAPVVVHCPLGI
  ..          | | | .| |. ..       .. .  .  |     ||. ..  ..   |  | .|      .| .  |  .    ||||||  |.
gdiav......rvdrnielpnyvirgfk.......vfnerdttek....ertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagv

ERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAA
 |    .||||   ||  .   |. | |  ||..|   ...| || |.. |
GrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiyna

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 732-829 3.5e-14 47.6 In-house 53-143 (297) alignment
Range on Protein: 732-829
Range on HMM: 53-143/297.0
SRNRSPSVLPNIHSRVYLSVDMSSDtalRDEYINANYMRGLGGvdrRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVaVGTRYWPTRTIW
...|   .||   ||| | .  ..      .|.|| ...|      |.| || | ..| .||| ||.|.. |..|    . |      .|||. ... 
eksRYkniLPydssRvkLaivnddp...dsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvt

subfamily_egg_pd Subfamily egg 732-825 9.7e-12 39.2 In-house 42-129 (307) alignment
Range on Protein: 732-825
Range on HMM: 42-129/307.0
SRNRSPSVLPNIHSRVYLsvDMsSDTALRDEYINANYMRGlGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDgvAVGTRYWPT
 . ||. |  .  ||| |  ..       |..| ||...| . .   |||.|||   | .||| ||. .|.  .|     .|        ||| 
ekarskrvhckdssrvkl..el.rrGqylddfihanrvkG.kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpk

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 733-978 4.7e-27 89.7 In-house 6-233 (237) alignment
Range on Protein: 733-978
Range on HMM: 6-233/237.0
RNRSPSVLPNIHSRVYLSVDMSSdtalrDEYINANYMRGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIWHQM
.||  ..    |||| |    |.      .||||.|..|. |  ...| .| |  ..|.||| |||.. |||.|   ||.|       .|||        
knrygnivaydhsrvvlkgagsg.....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

PVMTTHGPKKTrkrtiRLNDYKIKLVHEAE-LDHAiysriklwkgalGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGM---RTGSAPVVVHCPLGI
 |.|    ||       . || .. .  .. |               . | .    . |   .  ||.. .     ...       . |.| ..||  |.
gvltvslkkke.....efsdytvrslllskrltlk............evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagv

ERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHA
 | ..|. .| .  |  ..   |.   |  . .||   |.. .|| |.| 
grtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihq

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 733-980 2.5e-24 81.3 In-house 28-251 (284) alignment
Range on Protein: 733-980
Range on HMM: 28-251/284.0
RNRSPSVLPNIHSRVYLSVDMSSDTalrDEYINANYMRGLGGVDrRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHglvedgvavgtrywptrtiwhqM
.||   .|.  ...| |   .  .     .|||| .. |    | ..| || | . | .||| |.|...|| .|                          
knrighilafdknvvklerliGeef...sdyinasfitGyqrkd.kyiatqGPldntladfWrmiweyncstivllt......................k

PVMTTHGPKKTRKRTIRlNDYKIKLVHEAELdHAIySRIKLWK--GALGPRTLTHVWMLSTGSKREPQHARTWNTVVRD---VAGMRTGSAPVVVHCPLG
   . . |.|. ..  |  . |...|.|.|  ...   |.| .     . |...   .|    .  |...    ..|.    .     . |..||||  |
dkcsqywplkivikeer.fkvkvdsveesee.yvv.rdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsag

IERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
. |  |...||.|  .. ..   ||  .| .|||.|   ...| || |...| 
vgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 733-825 2.4e-11 38.1 In-house 36-124 (297) alignment
Range on Protein: 733-825
Range on HMM: 36-124/297.0
RNRSPSVLPNIHSRVYLSVDMSsdtalRDEYINANYMRGL-GGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPT
.||   .|    .|| |   ..       .||||.|.       | ..||.| |  .| .|||..|..|.  |.|    | |||    . ||| 
knryrdilatddtrvkllrvit.....erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywps

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 733-826 6.7e-11 36.4 In-house 59-143 (290) alignment
Range on Protein: 733-826
Range on HMM: 59-143/290.0
RNRSPSVLPNIHSRVYLSVDMSSDtalrdeYINANYMRGLggvDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTR
.||   |  |  .|| |.     |      |. |||..||   .  ||||| .   |  |.| || ... ...|    |.||| |   .|.| .
knrykdvvcndktrvilkdGydGd......yvhanyvkGl...kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypek

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 733-827 3.1e-08 27.5 In-house 55-144 (310) alignment
Range on Protein: 733-827
Range on HMM: 55-144/310.0
RNRSPSVLPNIHSRVYLSVDMSSdtalRDEYINANYMRGlGGVDRRFILTQAPSPTTCEDFWHMVWDQEC-SVVVQCHgLVEDGVAVGTRYWPTRT
.||   |.    ||| | .| |      ..|| |||..    .   || .| |   |  ||| |.... . |... |.  .|.|      |||.  
knrysdvvcldtsrvklkidksr....yedyihanyvkt.nylrstficsqgplqhtiidfwrmifqeraesilllck.vgeegrpkcvgywpslg

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 734-806 2.6e-06 21.3 In-house 51-112 (303) alignment
Range on Protein: 734-806
Range on HMM: 51-112/303.0
NRSPSVLPNIHSRVYLSvDMSsdtalrdeYINANYMRgLgGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVV
||   |.   ||.| || | |        || |.|.  |   ... |||| | . |. ||| |. .|   .|.
nrfvdvicldhskvkls.dss........yihasyle.l.dsskkailtqlplshtaadfwqmiieqkvkcvl

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 741-978 6.7e-13 42.9 In-house 47-263 (281) alignment
Range on Protein: 741-978
Range on HMM: 47-263/281.0
PN-IHSRVYLSVDMSSDTAlrDEYINANYMRGlGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTiwhqmpvmttHG
|    ||| | |.|    .   .|| |||.|    . | .|||| |   |  |||.|.|... . .|    ..|      . |.|  .          | 
pcldisrvqlkvkmpnkns..tdyihanyirs.pflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna..........hc

PKKTRKRTIRLNDYKIKlvheaelDHAIYSRIKLWKGAlGPRTLTHVWMLSTGSKREPQHARTWNTVVRDvagMRTGSAPVVVHCPLGIERGAVFVALDI
  .  | ..  .|  ..          . .|..|       | .||         . |. .     ..|    .|. |.| |.||  |. |   ..|..|
clqfdklsvsyedstvn.......kslvttrlnlsyeg.etrlithwlwkewpdwqvpessevmlkilrk...irarstppvihcsagvgrsgtlmavei

L-QMQLIQQGTADVLGTVCQLRQ-DRGLCINSLEQYRFLHA
  |    .    |.   | .||   |   ...|.|| ..  
alqsihshftlpdikqivshlrvtgraasvqtlqqymliwk

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 746-983 2.6e-21 70.6 In-house 56-292 (301) alignment
Range on Protein: 746-983
Range on HMM: 56-292/301.0
RVYLSVDMSSDtALRDEYINANYMRGLGGvDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIWHQMPVMTTHGPKK---
|. |.   . |   . |||||.|. |     ..|| .|.|   |  |||...|..  . .|   .| |.  .  ..|||. .  ..  .  |   ..   
riilkpkpnld.lcqreyinasyidgyse.kkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqv

TRKRTIRLNDYKIKLVHEaelDHAIYSRIKLWKGAlGPRTLTHVWML---STGSKREPqhaRTWNTVVRDVA--GMRTGSAPVVVHCPLGIERGAVFVAL
    .||    ||. . .   .  | ...|  .    ..... . .      |  |||   ||   |. ||     . | .||||||  .. |  |....
yPdfvirqlnvkiqdgsn...ngyierkfkvksdk.sswdvlqlqvtdWpqdGvvrep...rtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsv

DILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTF
.|   |   .|  || . .  .|. .   .  |||| ... .  ..
siglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy

subfamily_eak_pd Subfamily eak 747-994 2.6e-11 37.5 In-house 64-315 (332) alignment
Range on Protein: 747-994
Range on HMM: 64-315/332.0
VYLSVDMSSDTALRDEYINANYMRgLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRT--IWHQmPVMTTHGpKKTR
 .  | ..|    |. ||||  .  .  | |..||| ..| .    || || .|    .||    || ..    .|.| .|   ..   ..  .  |.  
drylvrltssqlnrlGyinaslae.fsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkf.Gildver.kefv

KRTIrLNDYKIKLVHEAELDHAIYSRIKLWKGALGPRTLTHV----WMLSTGSKREPQ-HARTWNTVVRDVAGMRTGSAPVvVHCPLGIERGAVFVALDI
|| | |.  ...|    |  .  . ..  |     |.    .     |  .|     . ..   .....         ||. . .  |  |  ||| .|.
krni.letrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapi.iqsarGsaraGvfvvidl

LqMQLIQQGTA---DVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTHENQLGRA
| ..||..       |   . . .. |  ..    |. |.. .   . .. .|.|   
l.irlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrdl

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 756-989 3.7e-13 44.3 In-house 41-264 (290) alignment
Range on Protein: 756-989
Range on HMM: 41-264/290.0
DTALRDEYINANYMRGLGGVdrRFILTQAPSPT-------TCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTrYwptrtiwhqmpVMTTHGPKKTrKRTI
 . . |.|| ||..    |.  |.||||.|          | |.|| |. . .   ||.     |     ..               .   |..     .
gkrfnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantsl.f...........aCakYvpesv.geel

RLNDYKIKLVHEAELDHAIYSRIKLWKGALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAgmrTGSAPVVVHCPLGIERGAVFVALDIlQMQLIQ--
.... ..|  .  . |  .  .. .  .   . |.|| .. .  .   ... .|  .... |    .  .||.|||  || | |.. |...  .|.|   
kfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk...asktpvivHcvdGiSrsAalaaiil.gyQkiaet

QGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTHEN
.|   .   . .||. | |.| | ... |  |..   |    .
sgsvkledvlkalrkqralaitsalelafvdagivllaievld

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 758-985 3.5e-17 57.1 In-house 70-288 (305) alignment
Range on Protein: 758-985
Range on HMM: 70-288/305.0
ALRDEYINANYMRGlGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTiwhqMPVMTTHgpKKTRKRTIRLNDY-KIK
.   ||| |||.       .||| ||||   || |||.| ...    .     |.| |    . |....      .|.. .  .| .| .....   ..|
pwpheyihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskd....kdvlefe..ekgqkisvkfessvtlk

LVHEAelDHAIYSRIKLWKGALGP-RTLTHVWMLSTGSKREPQhARtwNTVVRDVAGMRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQG-TADVLG
....|  .  .   . . .|. .  |  ||        .  |  |   ....  ..  |.   |.||||  || |    | |. .  ||..     |   
frkda..kakvtetvlviegpgekarkvthyhwidwpdrgvpa.ad..lailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdk

TVCQLRQDRGLCINSLEQYRFLHAAAWTFAR
 . ..|..|   |.. .|| |.|     . |
ilqkireqrnnsiqtdaqylfvhqvilnyfr

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 760-825 2.7e-08 27.8 In-house 79-144 (305) alignment
Range on Protein: 760-825
Range on HMM: 79-144/305.0
RDEYINANYMRGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPT
  .|| |||.      ..||| .| |   | ..|| || ..    .|     || |    ..|||.
psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpa

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 760-826 3.8e-06 21.2 In-house 12-72 (130) alignment
Range on Protein: 760-826
Range on HMM: 12-72/130.0
RDEYINANYMrGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQChGLVEDGvavgTRYWPTR
 ..||||... || |  . ..|||.|   |. |||.|. ..   |.|   | ||.       |||  
gntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvl.gsveee....deywpds

0051429 (Phosphotyrosine protein) phosphatases II 761-985 7.1e-24 80.3 In-house 4-226 (272) alignment
Range on Protein: 761-985
Range on HMM: 4-226/272.0
DEYINANYMRGLGG--VDRRFILTQAPSPTTCEDFWHMvWDQECSVVVQCHGLVEDGVAVGTRYWpTRTIWHQMPVMTTHGPKKTrkrtirLNDYKIKLV
. ||||... |.|.  ...|......|.| |..|||.. ... ....|   ...| |     |||     ....|.. .. |  .      .... ..|.
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdryw.pgirylhlpilddsaptil......ygalrvtll

HEAELDHAIYSRIKLWK--GALGPRTLTHVWMLSTGSKREPQHArtWNTVVRDVAGmrtgSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTAD-----
.|  |.. |. .. |..  .|  .|...| ....      ||.|    .... ..     . ||.|||  |. | ...|||..| ...  .  .|     
seellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

---VLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFAR
   ....| .||. |   . . |||.||. |.. ..|
nlyleeaveelraqrpgavqteeqylflyeallellr

0036282 (Phosphotyrosine protein) phosphatases II 761-977 1.4e-23 78.9 In-house 2-163 (174) alignment
Range on Protein: 761-977
Range on HMM: 2-163/174.0
DEYINANYMRGLGGVDrRFILTQAPSPttcedFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTrtiwhqmpvmtthgpkktrkrtirlndykiklvhe
. ||||... .    . |.|..|.| .     ||.|.... ...||..  ..|.|     .|||.                                   
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

aeldhaiysriklwKGALGPRTLTHVWMLSTGSKREPQHARtWNTVVRDVAGMRTG--SAPVVVHCPLGIERGAVFVALDILQMQLIqQGTADVLGTVCQ
              .     |.  ... | .    .|  .  . ..|. |   .    . ||.|||  |. | ...||.... ..|. ... |.| .| .
..............lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvre

LRQDRGLCINSLEQYRFLH
||. |. .. . .|||||.
lRlqrpgmvqtpsQyrfly

0051082 (Phosphotyrosine protein) phosphatases II 761-978 6.9e-17 56.9 In-house 3-147 (151) alignment
Range on Protein: 761-978
Range on HMM: 3-147/151.0
DEYINANYMRGLggvdrrFILTQAPSPttceDFWHMVWDQECSVVVQCHGLVEDGvaVGTRYWPTRTiwhqmpvmtthgpkktrkrtirlndykiklvhe
. |||..|. |       ......|..    ||. ..... ....| . ...| |    ..|.|                                    
sdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

aeldhaiysriklwkgalgpRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGmrTGSAPVVVHCPLGIERGAVFVALDILQMQliqqgtADVLGTVCQLR
                    ....|...|..     |..  . . ... ..   ... ||.|||  |. | ...|||... ..       ..  .. ..|
....................ievlhipildwpdpglplsfdavleflellld..kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyr

QDRGLCINSLEQYRFLHA
. |. .... .|..|.. 
lkrpgvvqpnqqflfqlf

0043147 (Phosphotyrosine protein) phosphatases II 762-978 1.6e-22 75.4 In-house 6-155 (172) alignment
Range on Protein: 762-978
Range on HMM: 6-155/172.0
EYINANYMRGLGgVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLvedgvavgtrywptrtiwhqmpvmtthgpkktrkrtirlndykiklvhea
 ||||.|. .   . .||| ||.| . |..|||.|.... ....| . .|                                                  
dyinasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltel..................................................

eldhaiysrikLWKGALGPRTLTHVWMLSTGSKREPqHARTWNTVVRDVAG--MRTGSAPVVVHCPLGIERGAVFVALDILQmqliqqGTADVLGTVCQL
           |  . |  |.  ... |.      | ... .  ... .     .  . ||.|||  |. | ...||.....         ... .|...
...........lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalv

RQDRGLCINSLEQYRFLHA
|. |. .. . .|||||. 
rekRpgavqnpsqyrflyy

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 762-978 4.6e-17 56.9 In-house 60-264 (285) alignment
Range on Protein: 762-978
Range on HMM: 60-264/285.0
EYINANYMRGLGGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRtiwhqMPVMTthgpkKTRKRTIRLNDYKIKLVHEA
.|| |..||  |  .  .| || | | |  |||||..... . |.    |.| ||   . |.| .     .  .      |  |  | | . | . .  .
dyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypek.....lgevv.....kfgkyeitlteckeeaiagt

ELDHaiYSRIKLWKGALGPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQ
 |.    . |.    .  |  . || .     .  |. ||    . . |  .     |..|||  |. | | || .|   ......   ..|  | ..| 
ilna..ltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremra

DRGLCINSLEQYRFLHA
 |  ...|  |. ||. 
mrfqavqshmqflflyv

0044763 (Phosphotyrosine protein) phosphatases II 762-978 5.9e-15 50.8 In-house 19-165 (178) alignment
Range on Protein: 762-978
Range on HMM: 19-165/178.0
EYINANYMRglggvdRRFILTQAPSpttcEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIwhqmpvmtthgpkktrkrtirlndykiklvhea
.||||...        ...|...|.    .|.. ..... ....| . . .| |     .|||...                                  
dyinaseil......pglylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.................................

eldhaiysriklwkgalgprtLTHVWMlSTGSKREPQHARTWNTVVRDVAGMR-TGSAPVVVHCPLGIERGAVFVALDILQMQliqqgTADVLGTVCQLR
                     ......  .    .|.  . .  .|. .   . .   ||.|||  |. | ...||.... ..       ..   . ..|
.....................iqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvr

QDRGlCINSLEQYRFLHA
. |  .. . .|.|.|. 
erRp.ivpnpgqlrqLye

0046846 (Phosphotyrosine protein) phosphatases II 763-980 1.4e-22 75.7 In-house 14-169 (176) alignment
Range on Protein: 763-980
Range on HMM: 14-169/176.0
YINANYMRGLggvdrRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTrtiWHQMPVmtthgpkktrkrtirlndykiklvheae
|||||.. |      |.| ||.| | |..||..|.... ...|| .  .|| |    ..|||    .... .                            
yinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi............................

ldhaiysriklwkgalgprtltHVWMLSTGSKREPQHaRTWNTVVRDVAGMRTGSAPVVVHCPLGIERGAVFVALDilqmqLIQ-QGTADVLGTVCQLRQ
                      ... | .     |.. . . .... .  ...   ||.|||  || | ...||..     |.. .   .|. .....|.
......................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvre

DRG-LCINSLEQYRFLHAAA
 |   .. . ||||||. ..
qRplgavqtpeQyrflyefe

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 764-975 6.1e-18 59.6 In-house 78-272 (301) alignment
Range on Protein: 764-975
Range on HMM: 78-272/301.0
INANYMRGLgGVDRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIwhqmpvmtthgpkktrkRTIRLNDYKIKLVHE-AE
| ||..    |  .||| ||.| . |.|||| |.   .   .|     ||. . . . | |...                  ...... .|||....   
ihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis.................ekldigrfkikiknkeli

LDHAIYSR---IKLWKGALGPRTLTHVWMLSTGSKREPQ-HARTWNTVvrDVagMRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQ
|.. |. |   ..   | . .||.||    .   .  |. || ... .  ..  ..    |.||||. || |   |.. ..|  ..  . | ..  .. .
lnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlm..el..vkksekPivvhcsaGiGrsvafigteylareveadptieltealkh

LRQDRGLCINSLEQYRF
||..|   ..  .|  .
lrehrwngvqtnsqlyw

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 776-977 1.8e-10 35.3 In-house 4-197 (199) alignment
Range on Protein: 776-977
Range on HMM: 4-197/199.0
DRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIWHqmpvmTTHGPKK-TRKRTIRLNDYKIKLVHEAELDHAIYSriklw
.||.| || |   |  ||| |||.     .|       .  |    ||||          . .|    | |      || |  .  ..   |  |     
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgt.....gkygslsvttktittkpdytitaliltnnttapps.....

kgalgPRTLTHVWMLSTGSKREPQHARTWNTVV--RDVAGM--RTGSAPVVVHCPLGIERGAVFVALDILQMQLIQ--QGTADVLGTVCQLRQDRGLCIN
      | ..|  . |   |  |. |     ||  |.|.    .   |||.|||  |     |||||||      .      |..    .||| |   | 
.....treishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiis

SLEQYRFLH
||..| |..
slqhynfiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 776-977 1.8e-10 35.4 In-house 3-196 (198) alignment
Range on Protein: 776-977
Range on HMM: 3-196/198.0
DRRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWPTRTIWHqmpvmTTHGPKK-TRKRTIRLNDYKIKLVHEAELDHAIYSriklw
.||.| || |   |  ||| |||.     .|       .  |    ||||          . .|    | |      || |  .  ..   |  |     
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgt.....gkygslsvttktittkpdytitaliltnnttapps.....

kgalgPRTLTHVWMLSTGSKREPQHARTWNTVV--RDVAGM--RTGSAPVVVHCPLGIERGAVFVALDILQMQLIQ--QGTADVLGTVCQLRQDRGLCIN
      | ..|  . |   |  |. |     ||  |.|.    .   |||.|||  |     |||||||      .      |..    .||| |   | 
.....treishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiis

SLEQYRFLH
||..| |..
slqhynfiy

0049260 (Phosphotyrosine protein) phosphatases II 777-977 4.1e-20 67.5 In-house 9-143 (152) alignment
Range on Protein: 777-977
Range on HMM: 9-143/152.0
RRFILTQAPSPTTCEDFWHMVWDQECSVVVQCHGLVEDGVAVGTRYWptrtiwhqmpvmtthgpkktrkrtirlndykiklvheaeldhaiysriklwkg
..|| ||.| | |..|||.|.... ....| .  |.|.|     .|.                                                     
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.....................................................

algprTLTHVWMLSTGSKREPQHARTWNTVVRDVagMRTGSAPVVVHCPLGIERGAVFVALDILQmqliqqGTADVLGTVCQLRQDRGLCINSLEQYRFL
     .  |...   |    .|. .  . ...     .  . ||.|||  |. | ...||....          ... .| ..|. |   . . .|.|||
.....qylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfl

H
.
y

0048076 (Phosphotyrosine protein) phosphatases II 843-979 2.6e-11 38.9 In-house 18-138 (145) alignment
Range on Protein: 843-979
Range on HMM: 18-138/145.0
TRKRTIRLNDYKIKLVHEAeldhaiY------SriklwkgalgpRTLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRTGSAPVVVHCPLGIERGAVFVA
| ..  .| |..|..|                .           |. .... |..    .|. .... .... .   .    ||.|||  |. | ...||
taldlellkdlgittvlnl......tselelle...........rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlva

LDILQMqliqQGtADVLGTVCQLRQDRGLCINSLEQYRFLHAA
.... .    .|  ..  .. ..|. |  .. . .|.|||. .
aylmll....lg.vsleealelvrsqrpgavpnpgqlrflyef

0048179 (Phosphotyrosine protein) phosphatases II 873-978 1.3e-10 36.7 In-house 48-139 (144) alignment
Range on Protein: 873-978
Range on HMM: 48-139/144.0
LwkgalgprtLTHVWMLSTGSKREPQHARTWNTVVRDVAGMRTGSAPVVVHCPLGIERGAVFVALDILQmqliQQGtADVLGTVCQLRQDRGLCINSLEQ
           .... |..     |...  ...... .   .  . ||.|||  |. | ...||....      .|  ..  .. ..|. |  .. . .|
e.........giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgq

YRFLHA
.|||. 
lrfLle

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 879-980 6.6e-07 23.0 In-house 87-190 (440) alignment
Range on Protein: 879-980
Range on HMM: 87-190/440.0
GPRTLTHVWMLSTGSKREPQHARTWNTVVRDVAG--MRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFL
  ||| .  . .   |  |. |     ...||     ..|..|..|||  |  | .| .|.| .  .  .    |..  .  .|..|   ... ||| |.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HAAA
| | 
heav

subfamily_PTPRN_pd Subfamily PTPRN 881-979 4.4e-09 30.4 In-house 187-287 (297) alignment
Range on Protein: 881-979
Range on HMM: 187-287/297.0
RTLTHVWMLSTGSKREPQHARTWNTVVRDVA-GMRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQ-GTADVLGTVCQLRQDRGLCINSLEQYRFLHA
||.|    ||  ..  |  |..     | |    |  |.|.||||  |  |  |....|..  .|..     |.  |.  ||..|   ... .|..|  .
rtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt

A
|
a

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 884-988 6.5e-07 23.1 In-house 188-289 (302) alignment
Range on Protein: 884-988
Range on HMM: 188-289/302.0
THVWMLSTGSKREPQHARTWNTVvrdVAGMRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTF
.. |  ... ..  . ..|   |    |    .....|.    |. | ..|..| .   .| ..    .  .| ..|..|   ..||.|| .|. |. ..
ltnWkqkkvpvkyaeliktaakv...fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiallly

ARTHE
 ... 
ikkkv

subfamily_CG42327_pd Subfamily CG42327 891-985 1.2e-11 38.9 In-house 219-316 (319) alignment
Range on Protein: 891-985
Range on HMM: 219-316/319.0
TGSKREPQH--ARTWNTVVRDVAGMRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQ-GTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFAR
 ||| |     ..  |  .   .| |    |.||||  |. |  . .| ||   .| .   . |.  .| ..|.||.  . . ||| |..  .  .|.
dgskaeagstssheingnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak

PTPc_DSPc_SM00012 903-979 1.7e-16 55.7 In-house 22-102 (105) alignment
Range on Protein: 903-979
Range on HMM: 22-102/105.0
WNTVVRDVAGMRT---GSAPVVVHCPLGIERGAVFVALDILQMQLIQQ-GTADVLGTVCQLRQDRGLCINSLEQYRFLHAA
  ...|.|   ..    |.||||||  |. | ..||||||| .|| .. .. |.. .|..||. |  .....||| ||..|
ilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyra

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 905-976 8.1e-08 26.2 In-house 204-275 (290) alignment
Range on Protein: 905-976
Range on HMM: 204-275/290.0
TVVRDVAGMRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFL
...| .  .|. | ||||||  || |   |||...    |..    |.|..|  ||. |   ..   ||  |
allrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylal

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 907-980 8e-11 36.6 In-house 208-280 (297) alignment
Range on Protein: 907-980
Range on HMM: 208-280/297.0
VRDVAGMRTGSaPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
||.. . .. . |..|||  |. | .|....|    .  .. . |..|.| .|||.|   .   |||.|.. | 
vrkdfsqnaeg.PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvav

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 909-990 5.6e-06 20.1 In-house 217-296 (310) alignment
Range on Protein: 909-990
Range on HMM: 217-296/310.0
DVAGMRTGsaPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFARTHENQ
 .| .| |  |.||||  |..|  | |||..   .| .    |.   . .|...|  ||..  || ...     |||.....
llaqvrhg..pcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifargetev

subfamily_egg_pd Subfamily egg 913-985 4e-08 27.3 In-house 197-271 (307) alignment
Range on Protein: 913-985
Range on HMM: 197-271/307.0
MRTGSAPVVVHCPLGIERGAVFVALDILQMQLIQQGTA--DVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTFAR
.|  | ||||.. ||. . |..||..|  ..|..  .    || .|  ||. | | ..|  .| |..     | |
lrnlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr

subfamily_PTPRA_pd Subfamily PTPRA 916-983 2.2e-09 31.6 In-house 228-294 (330) alignment
Range on Protein: 916-983
Range on HMM: 228-294/330.0
GSaPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAAWTF
.. |.||||  |. |   |..|| .  ..  ..  || ..| .||. |   ....||| |.. .   .
ag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 917-980 2.6e-07 24.8 In-house 228-291 (297) alignment
Range on Protein: 917-980
Range on HMM: 228-291/297.0
SAPVVVHCPLGIERGAVFVALDILQMQLIQQGTADVLGTVCQLRQDRGLCINSLEQYRFLHAAA
.|...|||  |. |  | |  |..  .| ..   ||   . .||. |   ...|||. .|. |.
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav