Gene PTPN12 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN12
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP064_AA protein Get Run
MbreP064_AA_3-289 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN6_pd Subfamily PTPN6 3-290 1.9e-80 265.2 In-house 18-299 (306) alignment
Range on Protein: 3-290
Range on HMM: 18-299/306.0
KSDQQDALEGFGAEFQRLRDMTaaYKASTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTtqrseDEDISGSDYINASSVE--HGESQCRFIASQGPLPHT
|.... . .||  ||..|. .    |   ||.||. .. |.||||| |.|.| .||.|.     .....|||||||. ..    .|....||.|| |..|
keeeslekagfeeefeelqqee..akkllsrkegakpenkeknryknilPfDhtrvilk.....epsvpgsdyinanyikkevkgsdksyiatqgclett

LDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDNMAEdAIDQDFLVRTLKVTH---KGASRIIYQYHYHAWPDHGVPARPGSVM
. |||||.|... |..||. .  |  . |||.|||. .| . . . .| |..|    .|. .|.|.|..   |. .| ..|||...|||||||. || |.
vsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavL

RLIAAFRERQPSDQ---AAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQMGLDAPcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
 ..   ...| . .   | |.|.|||||.|||| |.      |||. ..... ||||. .|| ..|  .|..|  .||||.|| ||||||   ...
dfledvnrkqeeleeaeagpivvhCsaGiGRtGtfi.....viDillkliekkgldad.idiqklvksvreqrsglvqteqqykfvykaikkyiet

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 3-287 2.6e-63 209.2 In-house 26-292 (319) alignment
Range on Protein: 3-287
Range on HMM: 26-292/319.0
KSDQQDALEGFGAEFQRLRDMTAAykaSTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSededISGSDYINASSVEHGESQCRFIASQGPLPHTLD
||| .| |  . .||.|. ....     . ..     . | |||. .|...| |.| |         . .||||||| |.   .. ..||.||||. ||.
ksdfdddltklevefrracklgvn...ladqtfanldqnkdknriinilafdknvvklerliG....eefsdyinasfvtGyqrkdkyiaaqGPldntla

DFWRMLWEKDVRIVVMACnifendRFKCAKYWPNLHEFdVFDEFEVDnMAEDAIDQDFLVRTLKVTHKG---ASRIIYQYHYHAWPDHGVPARPGSVMRL
|||||.|| ..  .|.        . ||..|||.  .    ..|.|. .      ... || ......|     | | |.|.  |||.|||  |  .|||
dfWrmiweyncstivllt......kdkcsqywplkivi.keerfkvk.vdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrl

IAAFRE-RQPSDQAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD--L
.   |  ..  .. |..|.|||||||||| ..     ..|.. ...|.        |....|  ||| |. .||   || |.| |.|.  |
vkkvrhltskenhranivvhcsaGvGrtGvyi.....vldvlldrmke....ekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl

0036941 (Phosphotyrosine protein) phosphatases II 4-289 1.7e-83 275.6 In-house 6-278 (297) alignment
Range on Protein: 4-289
Range on HMM: 6-278/297.0
SDQQDALEGFGAEFQRLRDMTAaykaSTSREEGTTMHTKRKNRYKDIIPYDFNRVVLttqrsedEDiSGSDYINASSVEHGESQCRFIASQGPLPHTLDD
..... | ..  ||..| .. .    . |.. .    .. |||||||.|||..||.|       .| .|||||||| |.  . . .||| |||||.|..|
lekllflalllkefeellplll....lgslsvallpenleknRykdilpydhtRVkl.......dd.egsdYinAsyvdgydlkrkfIatqgPlpntved

FWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNL-HEFDVFDEFEVDNMAEDAI-DQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMRL
||||.|| .|...|| .. .|..| |||.|||.   |. ....| | .. .. . ..|. .|||.||.  .| ||.....||. |||||||  | |....
FWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldf

IAAFRERQPSD-QAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMgLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
| ..|....   .  | ..||||||||.|     |..|.|.....|..  |  ...||...| .||..|| .|||..||.|.| |.|.|..
ielvrkvlkllpsggpvlVHCsaGvgRsg.....tfiaadlmlqqledk.lkeggvdileavkklReqRpgavqtleqyrflyeallellk

0047943 (Phosphotyrosine protein) phosphatases II 4-287 1.1e-82 272.9 In-house 5-271 (273) alignment
Range on Protein: 4-287
Range on HMM: 5-271/273.0
SDQQDALEGFGAEFQRLRDMTAaykaSTSREEGTTMHTKRKNRYKDIIPYDFNRVVLttqrsedeDISGSDYINASSVEHGESQCRFIASQGPLPHTLDD
 .... | .. .||..|....     . ... .   . | |||||||.||| .||.|        . .|||||||| |.  ... .||| |||||.|..|
lekllgltllleefelllslkp....lltysvallpenkdknrykdilpydhsrvkl........gdggsdyinAsyvdgynlkrkfiatqgPlpntved

FWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHE--FDVFDEFEVDNMAEDAiDQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMRL
||||.||..||..|| ....|..| |||.|||.  .  . ....| | .. |.  ..|. ||||..|.   | ||.....||. |||||||. . |....
fwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllef

IAAFRERQPSD-QAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
| . |. . .. .  | |.|||||||||     ||..|.|.....|.  |    ..|....| .||..|| ||||..||.|.|.|.|..
ielvrkalealpsngpvvVHCsaGvgRt.....gtfialdllldqlekeg....gvdvleavkllrsqRpgmvqtpeqyrflyealley

0045450 (Phosphotyrosine protein) phosphatases II 4-288 1.2e-80 266.9 In-house 20-304 (307) alignment
Range on Protein: 4-288
Range on HMM: 20-304/307.0
SDQQDALEGFGAEFQRLRDMTAAYkaSTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEdedISGSDYINASSV--------EHGESQCRFIASQG
 ...| |.|. .||..|...|  .  . .....   . | |||||||.||| .||.|..  ..   ...||||||| |        .   .. .||| ||
lllldfltgllkefekllsvtvfl..lgeysiallpenkdknrykdilpydhtRVklssldgs...ledsdYiNAsyvrvpllllldgydlkrkfIatqg

PLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVT---HKGASRIIYQYHYHAWPDHGVPAR
|||.|..||||||||..|...|| .. .|..| |||.|||.  |. ....| | .. |.  .... ||||.||    .| ||.....||..|||||||  
PlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpps

PGSVMRLIAAFRERQPSD-QAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGLDAPcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
. .. ..| . |. . .. .  | ..||||||||||     |..|.......|.. |     .|....| .||..|| .||...||.|.|.|.|.|.
feelldfieevrkaleelpkggpvlVHCsaGvgRtG.....tfiaaylmlrqlekegtlld.vdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_Ptp69D_pd Subfamily Ptp69D 4-289 6.3e-69 227.4 In-house 15-287 (307) alignment
Range on Protein: 4-289
Range on HMM: 15-287/307.0
SDQQDALEGFGAEFQRLRDMTAAYKASTSREEGTTMhtkrKNRYKDIIPYDFNRVVLTTQRSEDEdisgSDYINASSVEHGESQCRFIASQGPLPHTLDD
| ..|. .|.  |...|   .   ....| ..  ..    ||||.||...| .||.|..   ...    ||||||| ..  . . .|||.|.|.  |..|
srkrdtdfglakeyekLeareidkstkvsekkenal....knRyedikafDktRvkLkkingked....sdYinasfikgykekkkfiaaqdPveatigD

FWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLhEFDVFDEFEVDnMAEDAIDQDFLVRTLKVTHKG-------ASRIIYQYHYHAWPDHGVPARPGSV
||||..|..| ..||  |. | .| |||||||.  .   ...  |. ...    .|.  |.|.|..|.       .|| . |||| .|.|  ||  . ..
fWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvk.lvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargl

MRLIAAFRERQPSDqAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
..||   || .  .  .|.|.||||||||.| |.     |.|...  ||.      . |||..|  ||..|. .||  .||||.|.|.||  .
lklieqvrelykln.rsPivvhCsaGvgrsgifv.....aldsllqqlka....edkvdifetvkdLrsqRnllvqsleqYvflyralldyss

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 4-292 1.2e-68 226.3 In-house 8-280 (281) alignment
Range on Protein: 4-292
Range on HMM: 8-280/281.0
SDQQDALEGFGAEFQRLRDMTAAYKASTSREEgttmHTKRKNRYKDIIPYDFNRVVLTTQRSEDedisGSDYINASSVEHGESQCRFIASQGPLPHTLDD
. .|.  .||  |.. |...     |. |...    . . ||||..|. ||  ||..| . ..      .|||||. |.  ... ..||.|||.|..|..
qlsqndnaGfieeyeklaaigvdntataskad....envlknrYsnivaYDatrvkvtpneenk....ntDYinanfvpgykgekeyiatqgPvPaslva

FWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDNMAEDAiDQDFLVRTLKV-THKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAA
||.|.||..|...||  .  |... || .|||. ..   . .. | ..|| .  . .. |..|. ...| .| . | .| ||||||||| .  ..   ..
fWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeee.katyierkfkleresgetreveqlaytaWPdhGvPattkellefrke

FRERQPSDQAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQMgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVL
 .. . ... ||||||||||||||| ..     |.| . . ....   ..  |. .||  ||..|  ||||  || |||||.|| ... |
vlkltekktkaplvihCsaGvGrtGtyi.....alDrlvkaveae...leeldvkavvaelrkernlmvqtvvqyefvykavldaldkel

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 4-290 5.5e-55 181.4 In-house 13-280 (287) alignment
Range on Protein: 4-290
Range on HMM: 13-280/287.0
SDQQDALEGFGAEFQRLRDMTAAYKASTSreeGTTMHTKRKNRYKDIIPYDFNRVVLTtqrsededISGSDYINASSVEHGESQCRFIASQGPLPHTLDD
....   |||   |. | ..|   .  |    . . . | |||...|...| .||.|             |||||. ..  ... .||....|. .|. .
kghakgnegfknqftvleqvtqredevth...niasqnkdknRltqilvpdnyrvllk........gehpdyinavfidgykekkafiiaesPmfntarn

FWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEfDVFDEFEVDNMAEDaIDQDFLVRTLKVTHKG---ASRIIYQYHYHAWPDHG-VPARPGSVMRL
||...... | ..|| |.  |||. .| .|||. .   |. |...  . |. . .....|.|.|..|.   . . . ||.. .|...| |.    ... .
fWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvi

IAAFReRQPSDQAAPLVIHCSAGVGRTGHFllgtiCAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
   ..  |     ...|.|||..|||.. |     ||...     |. |      |.|||.   |. .| .||| .|| |.....|  .. 
eemyk.tqrkrgntsivvhCsdtvGrsamf.....caaattinkckteG....viDvfqvlksqriqkpgsvqtveqykfindivleylds

subfamily_PTPN12_pd Subfamily PTPN12 5-297 1.2e-128 423.1 In-house 2-286 (290) alignment
Range on Protein: 5-297
Range on HMM: 2-286/290.0
DQQDALEGFGAEFQRLRDMTAAYKAST--SREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDedisGSDYINASSVEHGESQCRFIASQGPLPHTLD
..... | | .|||.|......|||..  |.|.|.......|||||||.|||..||.|.....|.    |||||||......|.....||.|||||.|||
eekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeee....gsdYinanfikgvegkleyiaaqgPLpktld

DFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDV-FDEFEVDNMAEDAIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIA
|||||.|||.|.||||||...|....||..|||. .| .. |.||||....|.|.|.|||.|||||.....||..||.||.||||||||... |...||.
dfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelie

AFRERQPsDQAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKQmGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVLASMDN
..||.|  ...||||.|||||||||     |||.|||.|...||. .  ....|.|..|. ||..|.|.|||..||..||||...|||. |.....
lvrelqe.sedaPlvvhCsaGvGrt.....Gtiiaidyvrellka.ekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiiee

0050432 (Phosphotyrosine protein) phosphatases II 5-291 7.7e-88 290.1 In-house 36-302 (308) alignment
Range on Protein: 5-291
Range on HMM: 36-302/308.0
DQQDALEGFGAEFQRLRDMTAaykaSTSREEGTTMHTKRKNRYKDIIPYDFNRVVLttqrsedeDiSGSDYINASSVEHG--ESQCRFIASQGPLPHTLD
.... | .. .||..|....     . ... .     | |||||||.||| .||.|        | .|||||||| |      ....||| |||||.|..
ekaldlglleeefeellsvkp....lleysvallpenkdkNrykdilpydhsRVkl........d.egsdYInAsyvdgyssklprkfIatqgPlpntve

DFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNL--HEFDVFDEFEVDNMAEDAiDQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMR
|||||.|| .||..|| ....||.| |||.|||.   ... ... | | .. |.  ..|. ||||..|.  .| ||.....||..|||||||  | ....
dFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilld

LIAAFRERQpsdQAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKQMgldaPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQV
.. . |...   .  | |.|||||||||     ||..|.|.....|..      ..|.|..| .||..|| ||||..||.|.|.|.|.... .
flelvrksl...pggpivVHCsaGvGRt.....Gtfialdllleqleke....ggvdvfeavkklReqRpgmvqtpeqylflyralleylklk

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 5-289 1.7e-73 242.5 In-house 21-291 (298) alignment
Range on Protein: 5-289
Range on HMM: 21-291/298.0
DQQDALEGFGAEFQRLRDMTAAYKAStSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRsEDEDisgSDYINASSVEHGESQCRFIASQGPLPHTLDDF
...  | |. .|||||. ..   ..  . | . . . |.|||| |||..|. ||||...  .||.   ||||||| ..  . .  |||.|.||..|. ||
kkkkkltgyalefqrlnsvsseieee.ekevarkpenkkkNRyadiialdssRvvLeked.adee...sdYiNAsflhaykgrnafiatqaPltetvedF

WRMLWEKDVRIVVMACNIFENDRFKCAKYWPNlHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVTHKG--ASRIIYQYHYHAWPDHGVPARPGSVMRLIAA
|||..|.|.  .||  |. | |. |. ||||. .. . ..|..|. ....    |. ||.|||..|    .| . | |.  |||.|||.   ||. |.. 
WrmvteedigtiVmltnleeldktkyhkywPd.egketygeitvsllskee.fadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrk

FRERQPSDQAAPLVIHCSAGVGRTGHFllgtiCAIDivwSMLKQMGLDApCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
 |  |     .|....|||||||.| |     .|||   |.| ..  .    |.||||  ||..||..||||.||||.|.|.|. ..
vrasqqqagnkpvivqCsaGvgRsGtf.....iaid...svlervkkeq.vvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald

0039614 (Phosphotyrosine protein) phosphatases II 6-290 6.3e-83 273.9 In-house 27-291 (297) alignment
Range on Protein: 6-290
Range on HMM: 27-291/297.0
QQDALEGFGAEFQRLRDMTAaykastSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEdisGSDYINASSVEHGES-QCRFIASQGPLPHTLDDF
...   .. .||..| ...       .....     | |||||||.|||..||.|.. .. |.   .||||||| |.  .  . .|||.|||||.|..||
kansktllllefeellslkp......dysiallpenkdknrykdilpydhsrvklkpedgvdl...dsdYinAsyvdgydlltrkfIatqgPlpetvedF

WRMLWEKDVRIVVMACNIFENDRfKCAKYWPNLHEfdVFDEFEVDNMAEDAiDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFR
|||.|| .|...|| .. .|..| |||.|||.  .  ....| | .. ..  .... ||||.||..| ||......|. |||||||  . ...... . |
wrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkveh.ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvr

ERQPSD-QAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKQMgldaPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
|.. .. .  | ..|||||||||     ||..|.......|.       ..|....| .||..|| .|||..||.|.|.|.|.|...
ealaelpkggpvlVHCsaGvgRt.....Gtfiaaylmleqleke....ggvdvleavkelreqRpgavqtpsqyrflydallellkr

subfamily_PTPRB_pd Subfamily PTPRB 6-290 3.2e-78 257.7 In-house 20-287 (293) alignment
Range on Protein: 6-290
Range on HMM: 20-287/293.0
QQDALEGFGAEFQRLRDMTAAYKASTSReegtTMHTKRKNRYKDIIPYDFNRVVLTTQrsedEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFW
..|.  .|  |...|...    . ....    ..  . ||||..|.||| .|| |..     .| ||||||||. ..  .|.  |||.|||||.|.||||
kadsdlrfseeyeelkavgkdqavkaae....lavnraknrytnilpydhsrvkLaal....kdesgsDYinanyipgynsprefiatqGPlpetvddfW

RMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDNMAEDAIdQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRE
||.||| ..|.||  ...|. . || .|||. .|  .. . .|. .||.   .|. .|.||.... ..| . |||. .||||||| .. ...... ..||
rmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeel.edwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvre

RQ-PSDQAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
..  . ...|.|.|||||||||| |.     |.| . . ...      . ||| .|  ||..|  .||||.||.|.....|||...
aiektaskrPivvhCsaGvGRtGtfi.....aldrllqaiee....edyvdifgivaelReeRnllvqtekqYifihqcvldllrk

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 6-288 2e-57 189.8 In-house 19-288 (325) alignment
Range on Protein: 6-288
Range on HMM: 19-288/325.0
QQDAlEGFGAEFQRLRDMTAAYKASTsreegTTMHTKRKNRYKDIIPYDFNRVVLTTQRsedeDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFW
 ||  .||  ||. |    .  |  .     .  . | |||.|.....| .|||| |..    | . ||||||| ..    .  |.|.| ||..|..|.|
aqdq.dgfahefgllpsddgiakkva.....mkpenkaknrfknvvaldksrvvletkk....ddpssdyinasylrddkkkdvflaaqaPltatindlW

RML--WEkdvRIVVMACNIFENDRFKCAKYWPNL-HEFDVFDEFEVDNMAEDAIdQDFLVRTLKV--THKGASRIIYQYHYHAWPDHGVPARPGSV---M
|..  |.     ||.  |.....  .||.|||.   .   |  .||  .. . |  |.. | |.|  ..|| .| . |... .|.| ||. || ..   .
rlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisil

RLIAAFRERQPS--DQAAPLVIHCSAGVGRTGHFLlgticAidiVWSMLKQMGLDApCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
.|. |  ||  .    ..|...|||||||||| |.     .   ..|.|...  ..   |||..|  ||..||.||.| |||...|.|. . .
qlvkavservtantkastpilvhcsaGvGrtGvfi.....s...lysalakviees.rvdifgfvkklrkdrpsmvetvdqyiliyealveay

0051299 (Phosphotyrosine protein) phosphatases II 7-288 5.5e-86 283.9 In-house 19-286 (288) alignment
Range on Protein: 7-288
Range on HMM: 19-286/288.0
QDALEGFGAEFQRLRDMTAAykasTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSededISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWR
.. | |. .||..|.....      ..  .   . . ||||.||.||| .||.|..  .    ..|||||||| ..  .....||| |||||.|..||||
angltglleefeellsllpd....ltlsaallpenleknRysdilpydhsRVkLsvldg....vegsdYinAsyidgynlkrkfIatqgPlpntvedFWr

MLWEKDVRIVVMACNIFENDRFKCAKYWPNlHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVT------HKGASRIIYQYHYHAWPDHGVPARPGSVMRLI
|.||..||..|| ....|..| |||.|||. ... ..... | .. |.  ..|. ||||.||       .| ||.....||..|||||||  | ......
mvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldfl

AAFRERQPsDQAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMgldaPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
 ..|. .. ..  | |.||||||||||     |..|.|.....|..      ..|....| .||..|| ||||..||.|||.|.|...
rlvrkala.sgggpvvVHCsaGvgRtg.....tfialdllleqleke....ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_PTPN23_pd Subfamily PTPN23 7-292 8.6e-60 197.0 In-house 11-284 (288) alignment
Range on Protein: 7-292
Range on HMM: 11-284/288.0
QDALEGFGAEFQRLRDMTAAYKASTSReeGTTMHTKRKNRYKDIIPYDFNRVVLTtqrsededISGSDYINASSVEHGESQC-RFIASQGPLPHTLDDFW
 |   .....|. |..  ..   ..|           |||..||.||| |||.|          |  |||||| |..  ..|  |||.|.||. || |||
ldgktaldkkfkeleqkqdkearkrsi..aiaklyseknrsrdilPyDhnRvklr........gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFW

RMLWEKDVRIVVMACNIFENDRFKCAKYWPN-LHEFDVFDEFEVDNMAEDAIdQDFLVRTLKVTHKGAS--RIIYQYHYHAWPDHGVPARPGSVMRLIAA
.|..|. ....||  .  | .. |...|||.   |  .|....|    .    . .  |.||.....|.  . .   ....||..|||| |....... .
lmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvret.ethvervlkletldadavksvshlqltsWpelGvPasPetllqflde

FRE---RQPSDQAAPLVIHCSAGVGRTGHFLLGtICAIDIVwsmLKQMGLDapcfDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVL
 ..    .     .|||.|||||||||| | |  ..|.  .    |. ||     || |||  ||. |  |||...|. |.|.|.|  ...||
vesayeavqrksktPlvvhCsaGvgRtgvfalv.yaavrel...ekgngll....diiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 7-291 6.2e-59 194.2 In-house 16-286 (290) alignment
Range on Protein: 7-291
Range on HMM: 16-286/290.0
QDALEGFGAEFQRLRDmtaaYKASTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTtQRSEDEDISgSDYINASSVEHGESQCRFIASQGPLPHTLDDFWR
.   ||| ..|..|       . . . . |.|   |..||...|..|| ||..|  . |...| .  .||||. ..  . . ..|| |||...|| |||.
akgnegfrnqfkmlds....gesehtvtvgltssnkllnRfanivvyddnritLr.pisghkDCt.neyinAcyikgykekkqyiatqgpvsntlvdFWk

MLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDvFDEFEVDNMAEDAIDqDFLVRTLKVTHKGA---SRIIYQYHYHAWPDHG-VPARPGSVMrLIAA
..|...| |.|| .|| |... || .|||.    . ..||..  . | ... ..  |.|.|..| .   .... ||.  .|...| |... .... .|. 
liwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtill.viee

FRERQPSDQAAPLVIHCSAGVGRTGHFllgtiCAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQV
  . |  .   ..|.|||..|||.. |     ||...     |. |      |.|||.  .|. .| .|||..|| .... .|  ....
myktqrkrgntsivvHCSdtvgrsavf.....caaattinkckteg....vidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 8-290 1.7e-71 235.6 In-house 18-281 (288) alignment
Range on Protein: 8-290
Range on HMM: 18-281/288.0
DALEGFGAEFQRLrdmtAAYKASTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQrsedEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRM
.. .||  |.. |    || . . | . |   . ..||||..|.|||..|| |.      |. .|.|||||| ..  ... ..||.||||..|..|||..
rnrtgfseeynsL....aalektksvtagrlavnakknRyrnilpyDekrvklkkl....eeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

LWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDnMAEDAIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQ
 .|...  .||  .. |... || .|||. ..   . ...|  . |.   .||..|.| . .|.  . | ||.| ||||||||.    .. |.      .
vyenktstivmltelveggktkCeeYWPdadkpknyGsvtvt.lveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvan

PSDqAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
..| . |...|||||||||| |.     |.| .  ....        |.. .|  ||..|. .|||. ||.|.|...|.|...
qad.tgpiivhCsaGvGrtgtFi.....aldalidavee....edyiDvagtvaklRkqRallvqtlkqYefiyevllsliee

subfamily_PTPRG_pd Subfamily PTPRG 9-300 3.1e-66 218.8 In-house 17-299 (563) alignment
Range on Protein: 9-300
Range on HMM: 17-299/563.0
ALEGFGAEFQRLRDMTAAykASTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEDIsgsDYINASSVEHGESQCRFIASQGPLPHTLDDFWRML
.  || .||. |   |..   .   |     . |||||| .|..||  || |.    .....   |||||. ..  . .  |||.||||..|.||||||.
gdigfseefealqsetis..kdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl...DYinAnyidGyqkskafiatqgplkdtfddFWrmi

WEKDVRIVVMACNIFENDRFKCAKYWPNlHEFDVFDEFEVDNMAEDAI----DQDFLVRTLKVTHKGA---SRIIYQYHYHAWPDHGVPARPGSVMRLIA
||. | |.||  |. |. | ||  |||.  |   .....|  ..|. .     . . .. ||. .|      . ..||||  |||||||  .  |.  . 
WeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvk

AFrERQPSDQAAPLVIHCSAGVGRTGHFllgtiCAIDivwSMLKQMGlDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVLASMDNSAL
   ..   ..| |.|.|||||||||| .     ...|   ..|||.  .    ..|...  .| .|. .||||.||.|...|.|....     . .. .
ks.saankaeaGPivvHcsaGvgrtGty.....ivld...tllkqiq.qenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqv

0043336 (Phosphotyrosine protein) phosphatases II 10-287 1.9e-80 265.6 In-house 19-276 (278) alignment
Range on Protein: 10-287
Range on HMM: 19-276/278.0
LEGFGAEFQRLRDMTAaykasTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTqrseDEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLW
  .. .||..|....       ... .  .. | |||||||.|||..||.|.     ..   .||||||| |.  . . .|||.|||||.|..|||||.|
ktllllefeellsfkl.....dtysiallpenkdknrykdilpydhsrvklsl....lggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvw

EKDVRIVVMACNIFENDRFKCAKYWPnlHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVT--HKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQ
| .|...|| .. .|..| |||.|||   .. ....| | .. |.  ..|. ||||.||   .| ||....|||..|||||||  . ...... |.||..
elgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal

PsDQAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
. |.  |...|||||||||     ||..|.......|.  |    ..|....| .||..|| .|||..||.|.|.|.|..
e.dsngpvlVHCsaGvgRT.....Gtfialyllleqlekeg....gvdleeavkelreqRpgavqtpsqyrflyealley

0040438 (Phosphotyrosine protein) phosphatases II 11-293 6.4e-84 277.2 In-house 18-281 (317) alignment
Range on Protein: 11-293
Range on HMM: 18-281/317.0
EGFGAEFQRLRDMtaayKAStSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTqrseDEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWE
 ..  ||..|...    | . .....     | ||||.||.|||..||.|.     .. . .||||||| |.  . . .||| |||||.|..|||||.||
talleefedllsl....kld.tysvaelpenkdknrypdilpydhsRVkLsp....lggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvwe

KDVRIVVMACNIFENDRFKCAKYWPNlHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQP
 .|...|| .. .|..| |||.|||.  |. ....| | .. |.  .... .|||.|..  .. ||.....||..|||||||  | .. ... | || ..
qgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale

sDQAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVLA
 |.  |...|||||||||     ||..|.......|.. |    ..|....| .||..|| .|||..||.|.|.|.|.... .| 
.dpggpvlVHCsaGvgRt.....Gtfiaaylmleqlekeg....gvdveeavkelreqRpgavqtpeqyrflydalleylkrklt

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 11-290 8.7e-70 230.3 In-house 23-285 (319) alignment
Range on Protein: 11-290
Range on HMM: 23-285/319.0
EGFGAEFQRLRDMTAAykastSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQrsedEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWE
 ..  ||. |.  ..      . .. .. . |.||||..|..||  ||||..     ... |||||||| ..  . . .||| |.|| .|..|||||.||
tllekefkllkeavnd.....tfdsaskeenkkknryqnilaydrtrvvlsel....dgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWe

KDVRIVVMACNIFENDRFKCAKYWPNLhEFDVFDEFEVDNMAEDAiDQDFLVRTLKVTHKGA---SRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQ
... |||| ... |. . |. ||||.  .| .. .. |.   |.   .|. .| ||. .| .   .| . ...| .||||.|| .  |.. |.   |. .
eessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeee.ledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksr

PSDQAAPLVIHCSAGVGRTGHFllgtiCAIDIvwsMLKQMGLDApCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
   |. |.|.|||||||||| |     ...|.   || .. ...   |.|..|  ||  |. |||...|| |.|.|.|. |. 
ektqsgPivvhCsaGvGRtGtf.....ivlda...mlervkeeg.vlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea

subfamily_PTPN9_pd Subfamily PTPN9 11-289 4.5e-62 204.7 In-house 16-291 (297) alignment
Range on Protein: 11-289
Range on HMM: 16-291/297.0
EGFGAEFQRLRDMTAAYKASTSREEGttmhTKRKNRYKDIIPYDFNRVVLTTQrSEDEdisGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWE
.|   |.. .|..... .. .|.  .      .||||.|.. ||  ||||... .|||    ||||||. |.  . .  ||| ||||..| .|||||.||
rGlskeyaeirnepveGtflasklra....nleknrytdvlcydetrvvlakv.dede...asdyinanfvdGykqkkafiatqGplkktvsdfWrmvWe

KDVRIVVMACNIFENDRFKCAKYWP-NLHEFDVFDEFEVDNMaEDAIDQDFLVRTLKVT--HKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQ
..|...||.  . |. | ||..||| . .. . | ...| |. |.   .|. ||.|...  ... || .  . . .|||.|||    |.. .. . ||.|
qevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnv.eveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekq

PSD------------QAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
 .             .  |.|.|||||.||||     | ...||  | |...|      |....|  ||. |  ..||..||.| |.|.|.  .
alavkelgdewkghpsgPPivvhcsaGiGrtG.....tfitldiclsrleevg....tvdvvetvkllrtqrafsiqtpeqyefcylavleyal

subfamily_CG7180_pd Subfamily CG7180 11-288 5.4e-48 158.1 In-house 13-290 (296) alignment
Range on Protein: 11-288
Range on HMM: 13-290/296.0
EGFGAEFQRLRDMTAAYKASTSREeGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEdisgSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWE
. | .|.. .  .|.  .  . .  |   . . |||. ...|||.|||||..   |..    ||||||. |.    .  .|  ..|  .|.|.|||....
rkfrveyklelkltprleigdCag.glrkenreknrdvkvvPyDynRvvLekldGeek....sdYinavyvdsflkkkeyivteapkketvdefWrlvyd

KDVRIVVMACNIFENDRfKCAKYWPNLHeFDVFDEFEVDNMAEDAIdQDFLVRTLKVTHK------------GASRIIYQYHYHAWPD-HGVPARPG---
...  ||. .. |.  . .. .||||      . |..|. . |.    ..  ||.|.|.|               ||. ....  |.  . ||       
eeisavvvLtktfdfak.mypsywpnks.keqygeifveiveekqy.anlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnali

SVMRLIAAFRERQ-PSDQAAPLVIHCSAGVGRTGHFllgtiCAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
 ..| .  .||.    .. .|.|...| |..|.| .     .|||.   .... .    ..|.|. |  ||..|| .|.. ..| ..|  .|. |
elrrrvrlwrekvdedpeegPvvvvssdGasRsGvy.....laidanlelvekee....evdvFeavktlrrsRpqLvenveeYkyiYdvlleav

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 11-288 1.3e-45 150.7 In-house 20-279 (439) alignment
Range on Protein: 11-288
Range on HMM: 20-279/439.0
EGFGAEFQRLRDMTAAYKASTSREegTTMHTKRKNRYKDIIPYDFNRVVLTtqrsEDEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWE
| |  .|. .  .   |.. .|    .  . . ||||||. ..|. ||.|     |   .  | ||||  ..    .  .||.|||  .| |||||...|
eifkeifekinstspdyaciasla..aqeydqtknrykdvgafdhtrvtlq....eipgvphshyinanyikGyyddklyiatqgpkkettddfwrlvie

KDVRIVVMACNIFENdrFKcakYWPNLHEFdVFDEFEVDnmAEDAI-DQDFLVRTLKVTHKG----ASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRE
| .  .|| .|..|   .|   |||   |  .. .  |   ..  |   .. .| .||  .       | . |.|| ||||. |||.   |. .. |   
kktvtivmltnlves..yk...ywpsdaev.cygdiavr..vdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrains

RQPSDQAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKqmgLDApCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
 . ...  |.|.||||||||||     || |.||    ||   |.    ||  .| .||..|  |||.  ||||.|.|.|. .
andkeeygpvvvhcsagvGrtG.....tiialdialeqlk...len.kvdikgivkvlrkqrkqmvqalcqyvfiynavledi

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 12-290 1.1e-33 111.3 In-house 23-289 (305) alignment
Range on Protein: 12-290
Range on HMM: 23-289/305.0
GFGAEFQRLRDMTAAYKASTSREegttMHTKRKNRYKDIIPYDFNRVVLTTQRSededisgSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEK
|. |||. .. .    |  . .|       . ||||||.   | ||| | .           .|| |  |       ||| .| || .|  ||| | ...
glraefvamkrfndfekmkafke....aqeagknrykdvgcldnnrvklegpwp.......heyihanyvstptnpkrfictqaplektcadfwymclqd

DVRIVVMACNIFENDRFKCAKYWPNLHE-FDVFDE--------FEVDNMAEDAIDQDFLVRTLKVTHKGA---SRIIYQYHYHAWPDHGVPARPGSVMRL
 |  . | ||. |    ||..|..  ..    |.|        ||  .  .   | .  |.  ... .|.   .| . .||.  ||| ||||   ... |
kveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailel

IAAFRerqPSdqAAPLVIHCSAGVGRTGHFLLgticaIDIVwsmLKQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
..  |   ||    |.|.|||||.||||  ..     .. .   |.|.       |  ...  .|. |   .||..||.||.. ||. ...
lekar...ps..kgpivvhcsagigrtgsvvm.....leyi...ldqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk

0046845 (Phosphotyrosine protein) phosphatases II 13-290 5.2e-86 283.8 In-house 2-276 (284) alignment
Range on Protein: 13-290
Range on HMM: 2-276/284.0
FGAEFQRLRDMTAAYKasTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTtqrSEDEDISGSDYINASSVEHG-----ESQCRFIASQGPLPHTLDDFWRM
. .||..|. .|  .    |.. .   . . |||||||.||| .||.|.   |.|.|...||||||| |.        ....||| |||||.|..|||||
leeefeellsltvkll..lslsvallpenlsknRykdilpydhsRVklk...sldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrm

LWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVTH---KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFR
.||..||..|| ....||.| |||.|||. .|. ....| | .. |.  ..|. ||||..|.   .| ||.....||..|||||||. | ...... . |
vweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvr

ERQPS-DQAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKQMGLDaPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
| ... ..  | |.|||||||||     ||..|.|.....|.. ||.  ..|....| .||..|| ||||..||.|||.|.|.... 
ellenlpgggpivVHCsaGvgRt.....Gtfialdllleqlekegll.lgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 13-297 9.5e-79 259.7 In-house 22-289 (318) alignment
Range on Protein: 13-297
Range on HMM: 22-289/318.0
FGAEFQRLRDMTAAYKASTSreegTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEdediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKD
. .|..||   ..   .  |    ..   |.|||| .|..||  || |... .|     |||||||. ..  ...  .||.|.|||.|..|||||.||..
lseeyerlsrseetvtslks....lepvnkaknryanilaydhtrvkLqmlege....egsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqn

VRIVVMACNIFENDRFKCAKYWPNLHEfDVFDEFEVDnMAEDAIDQDFLVRTLKVTHKG--ASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSD
 ...||  .. |. . |...|||.      ...  |. . |.   .|...|..|||...  .||.. |||| .|||.|||. ..|.. |.   .. | . 
savivmltqeeergkakvhryWPskgs.rsygklvve.lkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqks

QAAPLVIHCSAGVGRTGHFllgtiCAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVLASMDN
.| |.|.|||||||||| |     .|.||.   .|. .      |.||.|  ||..|..||||||||.|.|...|. ..   . .| 
gagpivvhCsaGvGrtGvf.....iavdillerikaea....lvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevda

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 13-288 6.7e-65 214.0 In-house 21-277 (315) alignment
Range on Protein: 13-288
Range on HMM: 21-277/315.0
FGAEFQRLRDMTaAYKASTSREEgttmHTKRKNRYKDIIPYDFNRVVLTTQrsedEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKD
|  ||. | |   .|.  ..||.       .|||||.|.|.| .||.|       .|.  ||||||| ..  ...  .|||||||. ..||||||.....
fseefhdlpdPd.iyrqrvaret....infkknryknilPldsarvklevi....ddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqek

VRIVVMACNIFENDRFKCAKYWPN-LHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERqPSDQ
|  .||  .  |.|. ||..|||.   .   | ...|. .  .| | |  .| | . .  .|| . |.... |||.||. . .|...|| . .      .
vttivmvtkkqegdkikcrqywPdrkadsvefGsikvellslea.dtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkk

AAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
  .|..||||||||||      ...|| | . .|.    .   |.|..|  ||..|| .||||..| |.| |.|. .
efsllvhcsaGvGrtG.....vvisidevvaqikr....trsvdvfnfvknlrakrpylvqteeeyafiydavledl

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 13-292 3.6e-34 113.0 In-house 8-263 (267) alignment
Range on Protein: 13-292
Range on HMM: 8-263/267.0
FGAEFQRLRDMTAAyKASTSreEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEdedisgsdYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKD
.  ||. .. ..   ..  |     ... . .||. | .||| .||.| |.  |        ||||| ||  . .  ||. |.||  |  ||. .. ...
iekefelikkisdt.sstis..qsiaeknqernrlddnlpyddtrvilrtkeee........yinasyvegyktknafivtqdplkntitdfltvihdqk

VRIVVMACNIFENDRFKcaKYWPNLHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVTHKGAS-RIIYQYHYHAWPDHgVPARPgSVMRLIAAFRERQPSDQ
| ..|.  ..|...  .   . |.. .   .... |.   |   ..|. . ||..  |  | . .  |.|. |    .  .|  .  |.. . . |  . 
vpvivlltkvftdnirl..fwPPkmgqakkyqdltvehsleke.endyqiitlelkfknesahnvtlyyykkwnin.tnnkp.ylkplfgilaknqleng

AAPLVIHCSAGVGRTGHFLlgticaidIVWSMLKQMGLDApCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVL
  |||..||.||||.| ||        .. |.|...  .    |||. .  .|. |...|.| ..|..... . .  .  |
nrPlvvacsdGvGrsGtfl........vidsqlerakteg.vsdifdflrkirsqriglvdtkeryiyihellaeyaegrl

DSPc_SM00195 15-288 5.8e-82 270.3 In-house 4-262 (263) alignment
Range on Protein: 15-288
Range on HMM: 4-262/263.0
AEFQRLRDMTAAYkastSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEdediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVR
.||..|...|       . .|.   . |.|||||.|.||| .|| |... ..    .|||||||. ..  ... ..|| |||||.|..||||| ||..|.
eefekleestspk....etteaekkknksknRyknilpydhtrVklkkeekk....egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvk

IVVMACNIFENDRFKCAKYWPNL-HEFDVFDEFEVDNMAEDAIDQDFLVRTLKVTHKG--ASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDq
|.|| .. .||.. ||..|||.  ..  .|....| .. ..  .... .|||..|..|   .| ..||.|..|||||||  . ||..|. |..... .  
iivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.

AAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
 .|.|.||||||||||     |...|||..| |..       .|||..|  ||..|| ||||..|| |.|.|||...
sgpivVhCsaGvgRtg.....tfvtidiilskleeekk....vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 15-288 5.8e-82 270.3 In-house 4-262 (263) alignment
Range on Protein: 15-288
Range on HMM: 4-262/263.0
AEFQRLRDMTAAYkastSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEdediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVR
.||..|...|       . .|.   . |.|||||.|.||| .|| |... ..    .|||||||. ..  ... ..|| |||||.|..||||| ||..|.
eefekleestspk....etteaekkknksknRyknilpydhtrVklkkeekk....egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvk

IVVMACNIFENDRFKCAKYWPNL-HEFDVFDEFEVDNMAEDAIDQDFLVRTLKVTHKG--ASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDq
|.|| .. .||.. ||..|||.  ..  .|....| .. ..  .... .|||..|..|   .| ..||.|..|||||||  . ||..|. |..... .  
iivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.

AAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
 .|.|.||||||||||     |...|||..| |..       .|||..|  ||..|| ||||..|| |.|.|||...
sgpivVhCsaGvgRtg.....tfvtidiilskleeekk....vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_PTPN13_pd Subfamily PTPN13 15-291 7.5e-66 217.2 In-house 15-272 (273) alignment
Range on Protein: 15-291
Range on HMM: 15-272/273.0
AEFQRLRDMTAAYKAstsrEEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSededisgsdYINASSV--EHGESQCRFIASQGPLPHTLDDFWRMLWEKD
 ||. ||.. .  ..    |.| . . |.||||....|||  || |  . .         ||||| .  . |. . ..||.|||||.| .|||.|.||..
eefkelrelkpldtc....evgkkkenkdknryrnvlPydetrvklgdegg.........yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqk

VRIVVMACNIFENDRFKCAKYWPNLHE--FDVFDEFEVDNMAEDAIDqDFLVRTLKVTHK--GASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQP
.....|  .  |... || .|||. ..    | . .||...     | .| ||.|.|...  |.|| . . .. .|||||||. . ......|  |. | 
aeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkld.gfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt

sdQAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQV
  .|.|.|.|||||.||.|     |. .||.|  ....       ||. ..|  ||. | ..|||.|||.|||||||......
..dagPivvhcsaGiGrsG.....tlitidvvlglierdk....efdvkeivrklreqrqgvvqtkdqyifvykailevlksl

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 15-285 2.2e-51 169.4 In-house 14-274 (287) alignment
Range on Protein: 15-285
Range on HMM: 14-274/287.0
AEFQRLRDM----TAAYKASTSREEgttmhtKRKNRYKDIIPYDFNRVVLTTQRSedediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWE
.|...|..     || .||..   .       .|||| |..|.| .||.|...        |||||||  |   . . .|||.|||.. |. ||||...|
kevdalkedsesstatfkaaeelaa......vkknryadvlPiddtrvllsaege.....lGsdyinanyvasytddeafiaaqgPiaatvrdfwravle

KDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDNMAEDAIDQDFLVRTLKVTHKGAS--RIIYQYHYHAWPDHGVPARPGSVMRLIAAF----R
. .  |..     |. | || ||||. .       . |  .  |  . .. ||.|.. .  .   |.. |... .|||....    ...|..        
trsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhie

ERQPSDQAAPLVIHCSAGVGRTGHFLLGTICAidivwsmlkQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAIL
 .. .... |||.|...|.||.| .|   ..          ....|    |. .|| .||..| |.||.  |. ..|.|. 
lardasevGPlvvhddvGiGrsGillatlvlv.........srledlGrvdvaavvirlreyraalvqavvqlrllyealv

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 15-286 6e-48 158.2 In-house 24-234 (392) alignment
Range on Protein: 15-286
Range on HMM: 24-234/392.0
AEFQRLRDMTAaYKASTSREEgttmHTKRKNRYKDIIPYDFNRVVLTTQrsedEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVR
 ||. | .  . |. .....|      ..|||||.|.||| .||.|       .||. |||.||| ..  ...  .|||||| . .|||||||.....| 
eefhdlpgpdi.ypqtvaqke....inlkknryknilpydsarvklevi....ddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvt

IVVMACNIFENDrfkcakywpnlhefdvfdefevdnmaedaidqdflvrtlkvthKGA-SRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRErQPSDQAA
 ..|  .. | |                                           ||   | . |.|.  |||..|| .  |....|   .  .  . . 
tiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtssllkfikevka.dfGqyth

PLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
||.|||||||||||      . .|| | .  |.  .     |.|..|  .|..|| ||||..|| |.| |.|.
pliihcsagvgrtg.....vvisidsvvahakktrm....vdvfnfvtnirrkrpymvqtkeqyafiygavle

subfamily_PTPN14_pd Subfamily PTPN14 16-289 1.2e-51 170.5 In-house 28-297 (300) alignment
Range on Protein: 16-289
Range on HMM: 28-297/300.0
EFQRLRDMTAAYKASTSREEgttmHTKRKNRYKDIIPYDFNRVVLTTQRSEdedisGSDYINASSVEH--GESQCRFIASQGPLPHTLDDFWRMLWEKDV
|..|.  . .  . ||.. .      ..|||.||..||. ||| |.... .      ..||||||..   | ..  .|..||||..|. |||.|.||..|
eyeripkkredallstaklp....enaeknrfkdvlPyednrvelsptken.....stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgv

RIVVMACNIFENDRFKCAKYWPNL---HEFDVFDEFEVDNMAEDAIdQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMRLI---AAFRE
...||  .. |. . |. ||.|.|   ..   |..|.| .   .   . .  ..||. |   .  | ..   |  |||||||  . . .  .    . |.
qlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfseds.dsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrr

RQ-----PSDQAAPLVIHCSAGVGRTGHFLLGticaiDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
.      . ..  |...||||||||||  .|      |.. . |..        || .|.  ||. |  .|||  || ||||...  ..
ktnseveskeskPPvlvhCsaGvGrtGvlils.....dlliatleh....neeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

subfamily_PTPRN_pd Subfamily PTPRN 25-292 2.1e-54 179.3 In-house 39-296 (297) alignment
Range on Protein: 25-292
Range on HMM: 39-296/297.0
AAYKASTSRE-EGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEdisgSDYINASSV-EHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNI
.||.|  | .  . . .. .|||.|...||| .|| |... |...    |||||||.. .|   .  .||.||||..|. |||.|.||. | ..|. ...
cayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaek....sdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrl

FENDRFKCAKYWPNlHEFDVFDEFEVDNMAEDAIDQDFLVRT--LKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRErQPSDQAAPLVIHCS
 |..  .|..|||. .  .|.. .||. ..|    .|.|||.  ||  ..  .| . |.|. .||..|||| . |.. .           ...|.|.|||
eeegvkqckrywpd.eGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnk.syrGrscpivvhcs

AGVGRTGHFllgtiCAIDIVwsmLKQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVL
.|.|||| .     ..||.|   |...   .   ||   .  ||. || .|.|.||. |...|. . |...|
dGaGrtGvy.....ilidlv...lnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevnail

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 27-291 8.6e-70 230.3 In-house 32-286 (305) alignment
Range on Protein: 27-291
Range on HMM: 32-286/305.0
YKASTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDedisGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFEND
|. ..| . |.. . |.|||.|.|...|..|. ||.. |.|     ||||||| |.  ... ..|..||||..|..||||...|  |. .|| ... |..
yeeeesidvgkkeankaknrlkeitlldddriiltekesld....dsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklvegg

RFKCAKYWPNLHEF-DVFDEFEVDnMAEDAIDQDFLVRTLKVTH---KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQAAPLVIHCSAG
. || .|||. .     |.||.|  . . .  .|.. | ||..    .  || . ||.   |||||||  ..|...||   ...| .|.  ||..|||||
kdkCrqYWpesktekkefgefsve.lksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsag

VGRTGHFllgtiCAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQV
||||| |     .|.||    ||. .      |.|.|.  ||..|. |||| |||||.. |. .|..  
vgRtGvf.....iavdialerlkkEe....vvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg

subfamily_eak_pd Subfamily eak 27-191 2.9e-12 40.7 In-house 38-196 (332) alignment
Range on Protein: 27-191
Range on HMM: 38-196/332.0
YKASTSREEGTTMHTKRKNrYKDIIPYDFNRVVLTTQRSEDEdisgsDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFEND
|.   | .|.. . . ..|   .|.|||.. | ||. . . .      ||||| .|  |   ..| .  .    .  ||.|. |.    .|.  .  |..
yqrllsisetarleavnrn.vvkivpydrylvrltssqlnrl.....GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelk

RFKCAKYWPNLH-EFDVFDEFEVDNMAEdaIDQD-FLVRTLKVTHKGASRIIYQYHYHAWPDHGVPA
  |  ||.|.   |   |  ..|.      . .. . .| |...    .  .. |... | .  .| 
leksdkyfpdktreelkfGildverkef..vkrniletrllelskGnethrvlhykvfGwtettlpk

subfamily_PTPRD_pd Subfamily PTPRD 30-297 1.5e-85 283.0 In-house 37-290 (564) alignment
Range on Protein: 30-297
Range on HMM: 37-290/564.0
STSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEdediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFK
... |. .  . |.||||..|..|| .||||.. . .    .|||||||| ..  ...  .||.||||..|..|||||.||......||  .. |... |
qftweaankpaNkaKNRyanivaYdhsRVvLskvegd....egsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvk

CAKYWPNLHeFDVFDEFEVDNMAEDAIdQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQpSDQAAPLVIHCSAGVGRTG
|.||||. .    ..|..|. ..|  . .|. .||.|...  .  || . |.|. .|||||||  . |...||   |. . ...| |.|.||||||||||
chkYWPekg.tetygeltVtleeeeel.adyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTG

HFllgtiCAIDIvwsMLKQMGLdAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVLASMDN
 |     ..||.   ||...       ||.|.|. ||..|.||||||.||.|...|||. ..    ... 
tf.....ivida...mlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnteves

subfamily_PTPRA_pd Subfamily PTPRA 30-288 1.7e-69 229.2 In-house 47-295 (330) alignment
Range on Protein: 30-288
Range on HMM: 47-295/330.0
STSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEdisgSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFK
 .. |  .    |.|||. .|.||||.||.|.... ..|    ||||||| ..  . . .|||.|||. .|..|||||.||..   .||  .. | .. |
qatlelaskeenkeknrvvnilPydfsrvilsvkeGvee....sdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeek

CAKYWPNLHEF---DVFDEFEVDNMAEDAIDQDFLVRT-LKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQAaPLVIHCSAGVGR
||.|||.   .   ..  | | .....|   ..|||.   . |.. .||.. |.|...||| |||. |  ...|... .. ..     |.|.||||||||
caqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGr

TGhfllgTICAIDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
||     | ...| |  ..|  ..     |.|..|  ||. || ||||. ||.|.||..|.  
tG.....tfivldavlervkaerk....vdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 32-292 5.9e-65 214.1 In-house 19-272 (274) alignment
Range on Protein: 32-292
Range on HMM: 19-272/274.0
SREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEDisgSDYINASSVEHG-ESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKC
..|| . . ...|||||.|.| .  ||.|... |||||   |.||||  .    | .  ..| |||||.|..|||||.....|...||  .. |... ||
dqeeldvfgsqtknryktilPnensrvllesesseded...ssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkC

AKYWPNLHEF---DVFDEFEVDNMAEdAIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQA--APLVIHCSAGVGR
|.|.|. ...   . ....|. .       .|. ||.| . .   .| .. | | .|||| .| .. ....|..  .| . ...|  || |.|||||.||
avyfPdaedyeiserygdveikveki.verndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGr

TGHFLlgticAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVL
|| |.     ||.|    |..        |....|  ||..|  ||||..|| ....|.   ....|
tGcfi.....aisiavrqlre....eivvdvlkivcnlrldrGGmvqtseqyelihralclylkrll

subfamily_ptpA1_pd Subfamily ptpA1 32-235 6e-43 142.1 In-house 38-252 (418) alignment
Range on Protein: 32-235
Range on HMM: 38-252/418.0
SREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQrsedEDISGSDYINASSVEhGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCA
   ||   |   |||| .|.| .. || |       .|  |||||||  .. |    .||..||||| |. |||||.||. .||.||     || | || 
etsegdkkhntsknrytnilpvnhtrvqlkki....qdkegsdyinanyid.gaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcd

KYWPNLH---EF-------DVFDEFEVDNMA-EDAIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQ-----PSDQAAPL
.|||.     .|       .||  . |. .   .  ... . | ...| .| .| | ||.|  |||| .| .   . .|. .  .||      ||.  |.
rywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpi

VIHCSAGVGRTGHFLLGTIC
..|||||||||| |    | 
ivhcsagvgrtgtfctavim

0045098 (Phosphotyrosine protein) phosphatases II 33-290 4.4e-74 244.6 In-house 25-274 (278) alignment
Range on Protein: 33-290
Range on HMM: 25-274/278.0
REEGTTMHTKRKNRYKDIIPYDFNRVVlttqrsededisgsDYINASSVEHGesQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAK
 ...     . |||||||.|||..||.              |||||| ..    . .||| |||||.|..|||||||| .....||... .|..| |||.
itpalylgnldknRykdilpydhsrVk..............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWPNlHEFDVFDEFEVDNMAEDAIdQDFLVRTLKVT------HKGASRIIYQYHYHAWPDHGVPARP--GSVMRLIAAFRERQP------------SDQA
|||. ... ....|.| .. |. . .|. .|||.||      . . || ....||. |||||||  |   |. .|.   ||..              |. 
ywpe.ggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg

APLVIHCSAGVGRTGHFllgtiCAIDIVWSMLkqmglDaPCFDIFQVVWFLRQHRPA-MVQTEDQYVFVYKAILDLVQQ
 | ..|||||||||| .     .|.... ..|     . . .|....| .||..||  .||...||.|.|...|.|...
gpvlVHCsaGvgRtGtl.....vaaylmlell.....e.ggvdlleavkelrsqRpglavqnleqyrflyefllelllr

subfamily_PTPN1_pd Subfamily PTPN1 34-291 5.8e-61 200.7 In-house 25-274 (290) alignment
Range on Protein: 34-291
Range on HMM: 25-274/290.0
EEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSededisgsDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKY
.|  . . . .|||.|. |||  |..|  .          |||||| ||  | . ..| .|||||.| | ||.|.||.. . |||  .. |... |||.|
reaklpenrnlnryrdvspydhsrikleradn........dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WPNLHE--FDVFD--EFEVDNMAEDAiDQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQ-PSDQAAPLVIHCSAGVGRT
||. .|    ...  ...|. ..|.   . . ||.|...      .| |...|| .||| |||  |.. ....   ||    |..  | |||||||.||.
wPqgeeekellledtklkvkliseer.ksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrs

GhfllgTICAIDIVWSMLKQMGlDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQV
|     |.| .| .   ... . |. . || .|.  ||..|  ..|| ||  | | |||. .. .
G.....tfclvdtclvliekkd.dlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvi

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 34-289 7.6e-49 161.0 In-house 33-294 (301) alignment
Range on Protein: 34-289
Range on HMM: 33-294/301.0
EEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSedEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKY
. |.. . |. ||.|.| .|| ||..|.....   |..  .||||| ..   .. .|||.|||. .|| ||||..|.. .  .|| .|  |. . || .|
tvglseenkalnrfknitvyddnriilkpkpn..ldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqy

WPN-LHEFDVFDEFEVDnMAEDAIDQDFLVRTLK-----------------VTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQAAPL
|||  .| . | .|.|  . ....  ||..| |.                 |... .|. . |..   ||..||   |  |.. |     || .   .|.
wpnseaeseefgpftvt.lvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpv

VIHCSAGVGRTGHFllgtiCAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
|.|||..|.|.| .     |...|     |  |      |.|||.  .|. .| .|.| .||...|..|   .|
vVHCSdtVsrsGvY.....csvsiglEQckaeg....VVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 34-289 3.2e-26 86.8 In-house 35-277 (312) alignment
Range on Protein: 34-289
Range on HMM: 35-277/312.0
EEG-TTMHTKRKNRYKDIIPYDFNRVVLTTqrseDEDIsgsdYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAK
 |  . .. |  ||| .|  .|  |  |.     ||..    || |  |       ||...||||  |   ||..        ... | . |.   ||||
sectaflkfkdlnrypniqcwdrgrftlag....denf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcak

YWPNL------HEFDVFDE----FEVDNMAEDAIDQDFLVRTLKVThkGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRErqpsdQAAPLVIHCSAG
|  ..       .  |. |     |.   . | | .  |   .| |  |    . .| . .|||||.|    . .||..| .      .  |.. |||||
yisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkat..gqesklnhyqwaswpdhgmpdscdtalrllsavkk.....dkkpviahcsag

VGRTGhfllgTICAIDIVWSMLKQMGlDAPCFDIFqvvWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
|||||     |.. |. . . |..        |.|    .||. |   |..  |||.. ...|... 
vgrtg.....tlaliesmiaalrhpr.kqnvkdsf...vllrkdrarsvrvfpqyvyalrcvlefly

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 34-95 1.5e-08 28.7 In-house 41-95 (95) alignment
Range on Protein: 34-95
Range on HMM: 41-95/95.0
EEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSededisgSDYINASSVEHGESQCRFIASQG
  |..     |||. .|.|||  ||||||.|        ||||||  |.    .  .||.||
tvgsseanipknrflnifpydatrvvlttkrd.......sdyinacfvdgyarkncyiaaqg

subfamily_egg_pd Subfamily egg 35-296 2.7e-27 90.2 In-house 34-278 (307) alignment
Range on Protein: 35-296
Range on HMM: 34-278/307.0
EGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEDisgsDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDrfKCAKYW
.  .   . | | | .   |. || |  .|    |    |.| |  |. .     || .| ||  | ||||||.....|. .||     |..  .|  ||
taasdnnlekarskrvhckdssrvklelrrGqyld....dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkese..rceyyw

PNLHE-FDVF--DEFEVDNMA-EDAIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIaafreRQpsdQAAPLVIHCSAGVGRTGhfl
|. ..   |.    ....|.  ... |  | |  ||.          ..    .   .    |  |.|..     |.    . | |...  || ...   
pkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdvysplrvlrkl.....rn...lskpvvvqdilGvskaa...

lgTICAIDIVW-SMLKqmGlDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVLASMD
  |. ||.|   |.|.  |     . . . | |||..|.  |..  .|.|||. .| ....|..|  
..tlvaieiallsllr..G.pitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsak

0040439 (Phosphotyrosine protein) phosphatases II 36-288 7.4e-74 243.8 In-house 6-246 (249) alignment
Range on Protein: 36-288
Range on HMM: 6-246/249.0
GTTMHTKRKNRYKDIIPYDFNRVVLTTQRSededISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWP
.  .  | ||||.||.|||..||.|.  ..      .||||||| ..   .. |||| |||||.|..|||||||| .....||... .|..| |||.|||
allpenkdknrypdilpydhsrvklsilpg....lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

NlHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVT--HKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSD-QAAPLVIHCSAGVGRTghfllG
.  .. ....| | .. ..   .|. ||||..|   .| || .....|. |||||||  . .....| | |. . .. .  |...|||||||||     |
l.ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRt.....G

TICAIDIVWSMLKQMgldaPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
|..|.......|.       ..|....| .||..|| .||...||.|.|.|.|.|.
tfiaaylmleqleke....lgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 36-288 2.6e-59 195.8 In-house 43-284 (297) alignment
Range on Protein: 36-288
Range on HMM: 43-284/297.0
GTTMHTK---RKNRYKDIIPYDFNRVVLTTQRSEDEdisgSDYINASSVEHGESqcRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRfKCAK
.|. . |    |.|||.|.|||..|| |    .. .    |||.||| |.  .   |.|..| | . |..|||.|.....| ..||  .  |.|. |||.
qtvaekkvnfeksRYkniLPydssRvkLaivnddpd....sDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcar

YWPNLHEFDvFDEFEVDNMAEDAIdQDFLVRTLKVTHKG--ASRIIYQYHYHAWPDHGVPA--RPGSVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTGH
||..      | .  |  .. .   . |. |.|.||.    | |.. ||..  |||. |.   .  |.. ||   |.   . . .||..||.||||||| 
yWsdkgvtt.fGdvsvvllsvser.eGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgv

FllgtiCAIDIVWSMLKQMgldaPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
.     ..|| | .  |.        |||..|  |||.|| .|||..|| |||.|.|. .
l.....ltidsvvaeakre....kevdifglvkklrqerpylvqtkeqykfvyvavleal

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 37-287 1.8e-60 199.9 In-house 21-256 (284) alignment
Range on Protein: 37-287
Range on HMM: 21-256/284.0
TTMHTKRKNRYKDIIPYDFNRVVLTTQRSededISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACnifendRFKCAKYWPN
   . | |||. .|...| |.| |         . .||||||| ..   .. ..||.||||. ||.|||||.|| ..  .|.        . ||..|||.
nldqnkdknrighilafdknvvklerliG....eefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

LHEFdVFDEFEVDnMAEDAIDQDFLVRTLKVTHKG---ASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRE-RQPSDQAAPLVIHCSAGVGRTGHFLlg
  .    ..|.|. .      ... || ......|     | | |.|.  |||.|||  |  .|||.   |  ..  .. |..|.|||||||||| ..  
kivi.keerfkvk.vdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi..

ticAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD--L
   ..|.. ...|.        |....|  ||| |. .||   || |.| |.|.  |
...vldvlldrmke....ekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 37-291 3.2e-60 198.4 In-house 16-267 (270) alignment
Range on Protein: 37-291
Range on HMM: 16-267/270.0
TTMHTKRKNRYKDIIPYDFNRVVLTTQRSedeDiSGSDYINASSVE-HGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWP
.. ..|. |||.||.|    ||.| . ..   | | . ||||  |.   ......||..|||| || .||||.||. |. .||. .. |. | ||..|||
eaargkklnRyadiLPsPatRvrleelee...d.sataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWp

NLHEFD-VFDEFEVDNMAED-AIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPG------SVMRLIAAFRE-RQPSDQAAPLVIHCSAGVGRT
.  .    . . ..  .|.  . .. .... |....|| .| .  ..|..||||||| ...      .......| |. ..  |.| ||..|||||||||
aepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRt

GhfllgTICAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQV
|     |. |.||.  .|.. .      |. ...  ||..|.|.||. .|| |.|||..  ....
G.....tlialDiavrlLeetk....kvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 37-286 2.3e-46 152.9 In-house 29-264 (283) alignment
Range on Protein: 37-286
Range on HMM: 29-264/283.0
TTMHTKRKNRYKDIIPYDFNRVVLTTQRSededisgsDYINASSVE---HGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKY
.. . |||||...|.|.| .|| | ..          |||||. .    . . . ..|..|.|| .|  |||.|......  .||  .. |. | ||..|
sadenkrknrnqeivpadqwrvelksesr........dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqy

WPNLHEFDvFDEFEVDnMAEDAIDQDFLVRTLKVTHKGA---SRIIYQYHYHAWPDHGVPARPGSVMRlIAAFRERQPSDQAAPLVIHCSAGVGRTGHFL
||.    | . || |  . ..   . | .. | . ....   . ..  | .  | . |  |   |... .   .  |   . .|.|.|||.|.|||. |.
WPkrGsed.yGeftvt.lrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvk.fnkvislqteskkgPivvhCstgiGrtavfi

lGTICAIDivwsmlkQMgLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
 .  ....       .. |     |.|.||  .|..|. .||| ||| .|....|.
.aasasvk.......da.ltesvvdvfavvkimreqrmmavqtldqyklvhelvle

subfamily_CG42327_pd Subfamily CG42327 38-201 1.1e-25 84.9 In-house 25-188 (319) alignment
Range on Protein: 38-201
Range on HMM: 25-188/319.0
TMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEDisgsDYINASSVE-HGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPN
 . .| |.|. ...|    ||||  . ..|.|     |..|| |  . .... .||.| .|  .  ||||..||.  |..| .....|.   .||.|.| 
PvtskdksrvinvvPlPetrvvlqrigdddkd....eyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPt

L---HEFDVFDEFEVDnMAEDAIDQDFLVRTL--KVTHKGASRIIYQYHYhAWPDHGVPARPGSVMRLIA
     . ... .. |  . . .... ... ||  |  .|  || .  | |  |.. .||| . ... .. 
ketldntslyGdilvt.lkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamll

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 39-289 3e-64 211.6 In-house 7-243 (250) alignment
Range on Protein: 39-289
Range on HMM: 7-243/250.0
MHTKRKNRYKDIIPYDFNRVVLTTQRsEDEDisgSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFkCAKYWPNlH
.. | |||| |||..|  |||| ...  |..   ||||||| ..  . .  |||.||||..|. |||||..|...  .||  |. |...  . .|||   
pqnkeknryadiialdssrvvLekek.gdke...sdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv.e

EFDVFDEFEVDNMAEDAiDQDFLVRTLKVTHK--GASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTGHFllgtiCA
. . . .  |. . ..    |. .|.||....    .||. |.|. .||| |||.   .|. |.   .  |.  ..||....|||||||.| |     .|
kaekyGdvtvsllskee.fadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGaf.....ia

IDivwSMLKQMGLDApCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
||   ..|...  .    |.|.|.  ||..|| .|....||||||..||  ..
id...avlerlkkek.vvdvfkvikvlrkdrphavesleqyvfvyeiilkald

subfamily_PTPN3_pd Subfamily PTPN3 39-290 6.8e-59 194.1 In-house 39-277 (280) alignment
Range on Protein: 39-290
Range on HMM: 39-277/280.0
MHTKRKNRYKDIIPYDFNRVVLTTQRsededisgSDYINASSVEHG----ESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYW
 .   ||||.||.|||  || |. ..        .|||||. |.      .   |.||.||||..|  |||.|.||......||  .. |. | || .||
penlsknryrdilpydatrvklkese........tdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyW

PNLHEFDVFDEFEVDNMAEdAIDQDFLVRTLKVTHKG--ASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSdQAAPLVIHCSAGVGRTGHFLLg
|. ..   . ||.|    | . .. ...| | ...|    .| | |  | ||||||||  . ......   |. . . .  |.|.|||||.|||| ..| 
Petedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg.keePvvvhCsaGigrtGvlil.

ticaIDIVWSMLKQmglDAPcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
    ...  ... .     | . . ..|  .|. | ..|||..|| || .||| . ..
....letalaliea...aep.vypldivrtmrdqramlvqtasqykfvCeailkvyee

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 39-287 7.7e-57 187.6 In-house 47-278 (315) alignment
Range on Protein: 39-287
Range on HMM: 47-278/315.0
MHTKRKNRYKDIIPYDFNRVVLTTQRSEdediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLh
.. |.|||| .||.||  || |     .    ..|||.||. ..  . . |.||.|||.. ...||||...|.|.  .||  |. |... |. ||||.  
ienkqknryiniiaydksrvqlpllend....phsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.

eFDVFDEFEVDNMAEDAiDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQpSDQAAPLVIHCSAGVGRTGHFllgtiCAID
   .. .. |  . |.   ... |||| |. .   | ..|.|| .||| |||.   ..| ||   .  .  ......|.|||||||||| |     ...|
.kviyGkitvtrkseev.nteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhh.tnsvgaivvhcsaGvGrtGtf.....itld

ivwSMLKQMGLDApCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
   ..|.|.  .    |.....  .|| |  |||. .|| |.|.|.|. 
...avldqaeaen.aidvynfitgvrqnrikmvqvaeqyqfiydallet

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 39-287 4e-34 113.0 In-house 41-270 (288) alignment
Range on Protein: 39-287
Range on HMM: 41-270/288.0
MHTKRKNRYKDIIPYDFNRVVLTtqrsEDEDIsgsdYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLH
. .  ..||...   |. || |.    .| |     ||.|  |  .. . |.| .| ||  |.. .|.|| |.||. .|| |.. |  . | |.|.|   
ianptrdryenlprcditrvkls....ddpdf....yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl

-EFDVFDEF-EVDNMAEDAIDQDFLVRTLKVTHKGASRI-IYQYHYHAWPDHGVPARPGSVMRLIAAFrerqpSDQAAPLVIHCSAGVGRTGHFLLGTIC
 |   .  .  |     . ||.   | .|.....|  .. . . |.. |.|.|||    | .||.  .      .   |.|.|.|||||||| . |  | 
GekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililia

AidivwSMLKQMglDapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
.      .|.    |     | ...  ||..|   .||| ||..|.. .|. 
l.....eslrld..d..flgirsllaklreerfkaiqtemqylyvhrcvlee

0042113 (Phosphotyrosine protein) phosphatases II 40-288 2.5e-73 241.8 In-house 8-243 (245) alignment
Range on Protein: 40-288
Range on HMM: 8-243/245.0
HTKRKNRYKDIIPYDFNRVVLTTqrseDEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNlHE
. | ||||.||.|||..||.|.     |.   .||||||| |   .   .|||.|||||.|..|||||||| .....|| .. .|..| |||.|||. .|
enkdknrysdilpydhtrvklsp....dggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge

FDVFDEFEVDNMAEDAiDQDFLVRTLKVT--HKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTghfllGTICAI
. ....| | .. |.  ..|. ||||.||   .. || ...|||. |||||||  . .. ... . |. . .|.  |...|||||||||     ||..|.
sltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRt.....Gtfiaa

DIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
......|.  .    .......| .||..|| .|||..||.|.|.|.|.|.
ylmleqlekel....gvsleeavkelrsqRpgavqtpsqyrflyeallell

0037934 (Phosphotyrosine protein) phosphatases II 40-287 4.4e-70 231.3 In-house 9-241 (243) alignment
Range on Protein: 40-287
Range on HMM: 9-241/243.0
HTKRKNRYKDIIPYDFNRVVLttqrsedediSGSDYINASSVEHGEsqcRFIASQGPLPHTLDD----FWRMLWEKDVRIVVMACNIFENDRFKCAKYWP
  . ||||.||.|||..||.|          .|||||||. ..  .   |.||.|||||.|..|    ||||||| .....|| .. .|..|.|||.|||
enlsknrysdilpydhsrvkl..........egsdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

nlHEFdVFDEFEVDNMAEDAIdQDFLVRTLKVTH---KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPS-------DQAAPLVIHCSAGVGR
   |. ....|.| .. |    .|. ||||....   .. .| ...|||..|||||||  | ...... . || . .       |.  |...||||||||
..gev.tygdftvtllseehl.ddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGhfllgTICAIDIVWSMLkqmgldapCFDIFQVVWFLRQHRPA-MVQTEDQYVFVYKAILDL
||     |..|.... ..|        ..|....| .||..||  .|||..||.|.|.|.| |
tG.....tliaaylmllll........gvdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_PTPRK_pd Subfamily PTPRK 40-286 8.6e-63 207.0 In-house 42-275 (314) alignment
Range on Protein: 40-286
Range on HMM: 42-275/314.0
HTKRKNRYKDIIPYDFNRVVLTTQRSEdediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHE
. ..|||..||..||  ||.|.|   .    . ||||||. ..  .    ||. ||||..|. ||||......   .||  .. |. |.|| ||||.  |
enreknrsgdilaydrsrvflitidgd....pssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedte

FdvFDEFEVDNMAEDaIDQDFLVRTLKVTH----KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSdQAAPLVIHCSAGVGRTGHFllgtiC
   .....|  .  . ......||...|..    . . |.. |... .||||.||    ....|..   . |.  .| ..|.||||| |||| |     .
v..ygdikvelvete.llaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtf.....i

AIDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
|||||  |... |.     |.|..|  ||.... ||.||.||.|.| .||.
aidivldmieregv....vdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 40-286 1.2e-52 173.5 In-house 2-237 (237) alignment
Range on Protein: 40-286
Range on HMM: 2-237/237.0
HTKRKNRYKDIIPYDFNRVVLTTQRSEdedisgSDYINASSVEHGES-QCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLH
. | |||| .|. || .||||    |.      ||||||. ..  .    ..||.||||  . ||||.|.|..   ..||   . |... || ||||. .
enkiknrygnivaydhsrvvlkgagsg......sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd

EFDVFDEFEVDNMAEDAIdQDFLVRTLKVTHKGA---SRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPS-DQAAPLVIHCSAGVGRTGHFLLgti
.   .  . |    ....  |. ||.| .....     |.|.||.. .|||.||| .  ...|.     .| |   ...| .||||||||||| ||.   
qpaaygvltvslkkkeef.sdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflv...

caIDivwSMLKQMGlDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
  ||   .||.|   .    ||.. |. . . || ..||.|||||....||.
..id...amlrqak.ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

0049772 (Phosphotyrosine protein) phosphatases II 40-290 5.1e-43 143.3 In-house 45-282 (314) alignment
Range on Protein: 40-290
Range on HMM: 45-282/314.0
HTKRKNRYKDIIPYDfNRVVLTtqrseDEDISGSDYINASSVEHGesqCRFIASQGPLPHTLDDF----------WRML--WEKDVRIVVM---------
  . ||||.||.|.| |||.|       ...||||||||| |      ..|||.||||..|..||          |||   .. .||..||         
lnrdknryldilpad.nrvilp.....glpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------ACNIFENDRFKCAKYWPNLHefdvfdefevdnmaedaidqD-------FlvrtlkvthkgaSRIIYQYHYHAWPDHGVPaRPGSVMRL
             ... .|  . .|.....|.                    .       |            .| ...|... .||...|  .  . ..
lsrLdaAlgKtpllildgngneptaadlellk....................eelydpelf............erlgikylripvpDgsap.lledfdef

IAAFRERqpsDQAAPLVIHCSAGVGRTGHFLLGTICaidivwsmLKQMGldapcFDIFQVVWFLRQHRP-----AMVQTEDQYVFVYKAILDLVQQ
.....|    |.  |...||.||.|||| |..  ..        .|..|     ... ... ..|. ||      .... .||.|...|.|.... 
lefieea...dkggpvlvHCkaGkgRtgtfvvaayl........mkllg.....vsleealedvrlkRpinpnpgfieqleqyefilealleylkf

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 40-287 1.8e-39 130.1 In-house 36-268 (281) alignment
Range on Protein: 40-287
Range on HMM: 36-268/281.0
HTKRKNRYKDIIPYDFNRVVLTTQRSEDEdisGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWP-NLH
  ..|||| .|   |  || |  .  . .    .||| |  .     .  .| .|||   |  |||||.|...   .|| |.. | .| |||.|.| | |
vnnkknrylnipcldisrvqlkvkmpnkn...stdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah

EFDVFDEFEVDnMAEDAIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERqpsdqAAPLVIHCSAGVGRTGhfllgTICAID
    ||.. |.   . .... ..   |.....| .|.| .. .. |||  ||     .....   | |     ..| ||||||||||.|     |. |..
cclqfdklsvs.yedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar.....stppvihcsagvgrsg.....tlmave

IVWSMLKQmglDAPCFDIFQVVWFLRQ-HRPAMVQTEDQYVFVYKAILDL
|    ..         || |.|  ||   | | ||| .||....| .||.
ialqsihs...hftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 40-287 1.3e-37 124.1 In-house 54-288 (305) alignment
Range on Protein: 40-287
Range on HMM: 54-288/305.0
HTKRKNRYKDIIPYDFNRVVLtTQRSededisGSDYINASSVEHG-ESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLH
 .. ||||.|.   | . | |  . |       |||| |  |      . |||..|||| .|.|.|| |. .. |  .|| |.  |  ..|||.|||  .
iaitknryqdvpcqdqsavkl.dkps......psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaq

--EFDVFDEFEVDNMAED-AI--DQDFLVRTLKVTHKGASRI-IYQYHYHAWPDHGVPARPGSVMRLIAAFRERQpsdqaAPLVIHCSAGVGRTGhfllg
    ..     |.|..    .  | .  . .|..|. |  .. . . ..  ||| |||    . . |..| |  .      |.|.|||||.||||     
geklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk.....vpivvhcsagigrtg.....

TICAIDIVwsmLKQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
|| ||. .   |...  . ||  . ..|  ||..|   .|.. ||.|... .|. 
tivaieyi...lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 40-199 4.3e-34 112.7 In-house 32-189 (297) alignment
Range on Protein: 40-199
Range on HMM: 32-189/297.0
HTKRKNRYKDIIPYDFNRVVLTTQrsededISGSDYINASSVEH--GESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNL
 . |||||.||. .| .|| |         |...|||||  |     |.. ..| .||||  |.||||....|.|||..|| ... |. | ||| |||. 
sslrknryrdilatddtrvkllrv......iterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

H-EFDVFDEFEVDNMAEDAID--QDFLvRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRL
  |     .. |. ... . .  . .|   |.. ..  || .    . .|||||||.    . |.
vqerlkagdvvveflsstsdefdrvil.telqliyrsesrvvrhvqflswpdhGvpsdledlvrf

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 40-285 2.7e-28 93.4 In-house 51-287 (310) alignment
Range on Protein: 40-285
Range on HMM: 51-287/310.0
HTKRKNRYKDIIPYDFNRVVLTTQRSEDEdisgsDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHE
.   |||| |..  |  || |. ..|  |     ||| |  |     .  || ||||| ||. |||||....    ... |.. |. | ||  ||| |  
kymhknrysdvvcldtsrvklkidksrye.....dyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgv

FDVFDEFEVDNMAEDAidQDFLVRTLKVT---------HKGASR---IIYQYHYHAWPDHGVPARPGSV--MRLIAAFRErqpsdqaAPLVIHCSAGVGR
 . .    | |..| .  ..| .  | ||          . |      .   ..  ||| |||         ||.|  |         | |.|||||..|
tetygcirvtnlsess..eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh.......gpcvvhcsagkdr

TGhfllgTICAIDIVWSMLKQmGLDapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAIL
..     ...|... .  |.. ||     |. .|.  |...|   .||| ||... .  .
ly.....vvvalklkidkldr.glk...vdaeevktellksraiciqtelqyliidrvri

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 40-138 2.1e-27 90.8 In-house 46-154 (350) alignment
Range on Protein: 40-138
Range on HMM: 46-154/350.0
HTKRKNRYKDIIPYDFNRVVLT----TQRSEDEDISGSDYINASSVEHG------ESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFK
..  |||||.|.||. .|| |     .  . .  .|..|||||. ..        ... ..|| |.||| |.|||.... . .|.....  . .|... |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CAKYWPNLH
| .||... 
cyrYWqegs

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 40-137 3e-17 57.0 In-house 47-156 (349) alignment
Range on Protein: 40-137
Range on HMM: 47-156/349.0
HTKRKNRYKDIIPYDFNRVVLTTQR----------SEDEDISGSDYINASSV--EHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDR
..  |||||||.||.  ||.|              || .     |||||  .   . . . ..|| | ||| |.|||....  . |..|.   . .|.. 
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl

FKCAKYWPNL
 || .|| .|
ekcdiywqel

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 41-286 2.8e-47 155.9 In-house 7-238 (239) alignment
Range on Protein: 41-286
Range on HMM: 7-238/239.0
TKRKNRYKDIIPYDFNRVVLTtQRSEDEDisgSDYINASSVEH-GESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHe
 | |||| .|. ||..||||  . |.|     ||||||| .     |   .||.|| .  .  |||||.|..   ..||   . |  . || .|||.   
nkaknryanivtydhsrvvle.klsndph...sdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.

fDVFDEFEVDnMAEDAIDQDFLVRTLKVTHKGA--SRIIYQYHYHAWPDHGVPARPGSVMRLIAAFReRQPSDQAAPLVIHCSAGVGRTGHFLLgticaI
   . .. |  . .  .  |...||. ... |    | .||||.  |||.|||    .|. |      ..    | | |||||||||||| ||.     |
.skycnlrvt.lrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit.kdslpgarpwvihcsagvgrtgaflv.....i

DivwSMLKQMGLdAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
|   .||.|        |||. |  .|. || |||| .||||.. |.|.
d...amlrqakk.qktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 41-285 3.3e-47 155.7 In-house 8-238 (239) alignment
Range on Protein: 41-285
Range on HMM: 8-238/239.0
TKRKNRYKDIIPYDFNRVVLTtQRSEDEDisgSDYINASSVEH-GESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHe
 | |||| .|. ||..||||  . |.|     ||||||| .     |   .||.|| .  .  |||||.|..   ..||   . |  . || .|||.   
nkaknryanivtydhsrvvle.klsndph...sdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.

fDVFDEFEVDnMAEDAIDQDFLVRTLKVTHKGA--SRIIYQYHYHAWPDHGVPARPGSVMRLIAAFReRQPSDQAAPLVIHCSAGVGRTGHFLLgticaI
   . .. |  . .  .  |...||. ... |    | .||||.  |||.|||    .|. |      ..    | | |||||||||||| ||.     |
.skycnlrvt.lrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit.kdslpgarpwvihcsagvgrtgaflv.....i

DivwSMLKQMGLdAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAIL
|   .||.|        |||. |  .|. || |||| .||||.. |.|
d...amlrqakk.qktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 41-287 7.5e-44 145.0 In-house 41-276 (307) alignment
Range on Protein: 41-287
Range on HMM: 41-276/307.0
TKRKNRYKDIIPYDFNRVVLTTqrsedeDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHE-
   ||||.|.   | .|.|...      |   |||| |  .       .||..||||  |  .|| |  ...|  |.| |.. |  . || .|||  .  
ntdknryqdvkcqdkgrivvkf......dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegq

FDVFDE----FEVDNMAEDA--IDQDFL-VRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQpsdqaAPLVIHCSAGVGRTGhfllg
  || |      |.|.  .    |.|.. | ||||   . || | .. .. |||.|||    . . |. | |  .      |.|.||||||||.|     
klvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt.....npvvvhcsaGvGrsG.....

TICAIDIVWSmlkQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
|| || .|     .|     | |. ..|  ||..|.  .||| ||..... .|. 
tivaislvqd...kmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 41-287 1.6e-20 67.9 In-house 47-278 (303) alignment
Range on Protein: 41-287
Range on HMM: 47-278/303.0
TKRKNRYKDIIPYDFNRVVLTtqrseDedisgSDYINASSVEHgESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEF
   |||. |.|  |  .| |.     |     | || || .|  .|. . | .| ||.||  |||.|. |. |. |..     | |..     .|.  .|
nmdknrfvdvicldhskvkls.....d.....ssyihasylel.dsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf

DVFDEF--EVDNMAEDAIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPAR--PGSVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTGHFLLGTICA
  |.|    | .. .  . . . .. | |.      ... .||.|||   .|.   |  | ..       .   .. | |    .|.||.| | |   . 
lkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetah

IDIvwsmlKQmglDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
. .     ..   . ...|. ...  .|. |   ||   |. .||  . . 
lsl.....hs...eqasldlvkclenvrngrlhavqnlsqfsvvytllaeh

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 41-145 2.3e-12 41.0 In-house 96-189 (244) alignment
Range on Protein: 41-145
Range on HMM: 96-189/244.0
TKRKNRYKDIIPYDFNRVVLTTQRsedediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDrfkcaKYWPNLHEF
   |||    .|.||||| |.          |  ||||| |      . .| .| ||  |  |||.|. |. | ..|.   . |.|     .|||.   .
nswknregaglpfdfnrvplskgs......mgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpdsepl

DVFDE
. ..|
ewyee

Y_phosphatase Protein-tyrosine phosphatase 42-285 3.1e-77 254.5 Pfam-A 2-234 (235) alignment
Range on Protein: 42-285
Range on HMM: 2-234/235.0
KRKNRYKDIIPYDFNRVVLttqrseDEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWP-NLHEF
|.|||||||.|||..|| |      ... . ||||||. |.  ... .|||.||||..|..|||||.|...|...|| ..  |..| |||.||| . .|.
kkknRykdilpydktrvkl......kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

DVFDEFEVDNM-AEDAIDQDFLVRTLKVTHKGASR---IIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQpSDQAAPLVIHCSAGVGRTGhfllgTICA
  .....| ..  | ...... .|.|....|....   ...|.||..|||||||. | |...|| ...... ... .|.|.||||||||||     |..|
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtg.....tfva

IDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAIL
.||....|.. .     .|..|.|  ||..|| |||...||.|.|||||
ldilleqleaeee....vdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 42-285 3.1e-77 254.5 In-house 2-234 (235) alignment
Range on Protein: 42-285
Range on HMM: 2-234/235.0
KRKNRYKDIIPYDFNRVVLttqrseDEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWP-NLHEF
|.|||||||.|||..|| |      ... . ||||||. |.  ... .|||.||||..|..|||||.|...|...|| ..  |..| |||.||| . .|.
kkknRykdilpydktrvkl......kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

DVFDEFEVDNM-AEDAIDQDFLVRTLKVTHKGASR---IIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQpSDQAAPLVIHCSAGVGRTGhfllgTICA
  .....| ..  | ...... .|.|....|....   ...|.||..|||||||. | |...|| ...... ... .|.|.||||||||||     |..|
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtg.....tfva

IDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAIL
.||....|.. .     .|..|.|  ||..|| |||...||.|.|||||
ldilleqleaeee....vdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 42-287 3.8e-65 214.9 In-house 44-275 (515) alignment
Range on Protein: 42-287
Range on HMM: 44-275/515.0
KRKNRYKDIIPYDFNRVVLTTQrsedEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLH-EF
 .|||||.|.||| .|| |       .|   |||.||| ..  ...  .||||||.. ..|||||......|  ..|  .  |.|. ||.||||.   . 
fkknryknilPydsvrvklevi....ndnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgds

DVFDEFEVDNMAEDAiDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPsDQAAPLVIHCSAGVGRTGhfllgTICAIDIV
  | ...|. .. .| . . . |.|.|..   || . |.|.. |||.||| .  |...|| . .  .    . ||.|||||||||||      ...|| |
vkfGsikvelvslea.ctggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhg.qythpliihcsaGvGrtG.....vvisidsv

WSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
 .  |.    .   |.|..|  .||.|| .|||..|| |.| |.|. 
vahakt....trmvdvfnfvtnirqkrpylvqtqeqyafiygavled

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 42-288 7.6e-42 137.9 In-house 57-283 (290) alignment
Range on Protein: 42-288
Range on HMM: 57-283/290.0
KRKNRYKDIIPYDFNRVVLttqrsedEDISGSDYINASSVEHgeSQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLH-EF
 .||||||..  |  ||.|       .|    ||. |  |.    .  || .||.|  |  |.|||. ...|  .|| |...|. . ||..|.|. . | 
fkknrykdvvcndktrvil.......kdGydGdyvhanyvkG..lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

DVFDEFEVDNMAEDAIDQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRErqpsdQAAPLVIHCSAGVGRTGHFllgtiCAID
  | |. |    ||  |..   .|| | .  .| . ... ..  .|||. |.    ...|.. . |.      . |.|.|||||.|||| |      ||.
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk.....asGpvvvhcsaGiGrtGtf.....vaie

IVWsmlkQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
.      |. ||   .|. ..|  ||. | . || . ||. . ...||| 
vgl....qilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlG

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 42-280 3.5e-29 96.5 In-house 51-273 (301) alignment
Range on Protein: 42-280
Range on HMM: 51-273/301.0
KRKNRYKDIiPYDFNRVVLTTQRSEDEDISgSDYINASsvehGESQcRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFD
| |.||. . | . .  |   .  .   |  ...|..|    |... ||||.||||. | .||| ||   ||  .|| ..  |.   ||..| |   . .
kdkhryptv.PckPstavevivdGkrvPih.anwipts....Ghph.rfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisek

V-FDEFEVDNMAEDAIDQD-FLVRTLKV---THKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRErqpSDqaAPLVIHCSAGVGRTGHFLlGTICa
.  . |..    .. | ..    |||.|   | | |.| .  | |. |.|.|||     .. |.   ..   |.   |.|.|||||.||.  |. || . 
ldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk...se..kPivvhcsaGiGrsvafi.gtey.

idivwsmLKQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFV
       | .  .  |  .. . .  ||.||   |||. |  ..
.......lareveadptieltealkhlrehrwngvqtnsqlywm

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 42-124 1.9e-13 44.6 In-house 38-118 (347) alignment
Range on Protein: 42-124
Range on HMM: 38-118/347.0
KRKNRYKDIIPYDFNRVVLTTQRSEDEDISGS-DYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVmacNIFE
  ||| ||    |  ||||. ..|.      .  ||||| .   ...  .| .| |||.|. |||.|.    |  ||    |||
lsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv...tife

0041856 (Phosphotyrosine protein) phosphatases II 43-288 9.7e-48 157.5 In-house 3-171 (182) alignment
Range on Protein: 43-288
Range on HMM: 3-171/182.0
RKNRYKDIIPYDFNRvvlttqrsededisGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACnifendrfkCAKYWPnlhefdv
 ||||.||.|||..|              ..|||||. .  .  ..|||| ||||..|. ||.|||.| .....|...         .  |||       
dknrysdilpydhsr..............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.......

fdefevdnmaedaidqdflvrtlkvthKGASRIIYQYHYHAWPDHGVPArPGSVMRLIAAFRErqpsdQAAPLVIHCSAGVGRTGhfllgTICAIDIVWS
                           .   | ..||.|. |||||||  . .. ..| . .|     .  | ..||||||||||     |..|......
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtg.....tlvaaylmkk

MlkqmgldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
.          ......| ..|..|| ||.|..||.|.. |.|.|.
l.........gvsleeavklvrsrRpgmvitpnqyfflqlallell

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 44-286 9e-30 98.6 In-house 38-268 (285) alignment
Range on Protein: 44-286
Range on HMM: 38-268/285.0
KNRYKDIIPYDFNRVVLTTQrseDedisgSDYINASSVE-HGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPN-LHEFD
 ||| |.   .  ||||  .   |      ||| || .   |. |  .|..||||| || |||.|.... .  |.| | .||    ||| |.|. | |  
lnryadvrcieetrvvlknh...d.....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

VFDEFEVD--NMAEDAIDQDFLV-RTLKVTHKGASRIIYQYHYH--AWPDHGVPARPGSVMRLIAAFRERQPSDqaAPLVIHCSAGVGRTGHFLlgticA
 | ..|.   .  |.||    |   |.  |   .|  .|  | .   |||.  |     .. |    .. .| .   |...|||||||||  |.      
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke..kpicvhcsagvgrtatfv.....g

IDivWSMLKQMglDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
||  .. .. |  . |  .....|  .|  |   ||.  |..|.|  ...
id..yatirim..enpniemldivremramrfqavqshmqflflyvvlme

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 44-289 2.2e-19 64.0 In-house 54-286 (302) alignment
Range on Protein: 44-289
Range on HMM: 54-286/302.0
KNRYKDIIPYDFNRVVLTTQRseDedisgsDYINASSVEHGESQCRFIASQGPLPHTL---DDFWRMLWEKDVRIVVMACNIFENDRfKCAKYWP-NLHE
||. .|.  .| |.| |...   |      .|.|||.||  | .   | .| |   .    ..|||| ... .  ||..    | ..    ...| .  .
knqsedvpildsnlvkleaep..d......syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

FDVFDEFEVDNMAEDAIDQDFLVRTLKVTHKGASR--IIYQYHYHAWPDHGVPARPGSVMRLIAAFrERQPSDQAAPLVIHCSAGVGRTGHFLLGTIcAI
.  .... | |   .  ...    .. |  .| |   ..  |. . |... || . ..... .|     . ..  ...||    |.|| | ||  .. |.
ykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlav.av

DIVwsmlKQMglDAPCfdIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
. .    ..   ..|.  | ..|  .|. ||..|.. .|||..| |.| ...
ekl....qkg..kepn..ikeivksiRsqRpravdslkQyvslyialllyik

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 44-199 3.5e-07 23.3 In-house 30-164 (169) alignment
Range on Protein: 44-199
Range on HMM: 30-164/169.0
KNRYKDIIPYDFNRVVLttQRSEdEDIsGSDYINAssvehgesqcrfiasqgplphtlddfwRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVF
|||    .   . || |  ||   ||. |||||||                           ||.|| .  ..|.  .  . . |   |   .||   ..
knrpagplapshtrvkl..qrvm.edl.gsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyqlhpavil

DEFEVDNMA--EDAIDQD-----FLVRTLKVTHKGASRII---YQYHYHAWPDHGVPARPGSVMRL
 |.  | .    | ...       |.    | |.  . .      .|| .||. |||  |  | .|
gewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvhvghl

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 44-199 6.4e-07 22.3 In-house 29-163 (169) alignment
Range on Protein: 44-199
Range on HMM: 29-163/169.0
KNRYKDIIPYDFNRVVLttQRSEdEDIsGSDYINAssvehgesqcrfiasqgplphtlddfwRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVF
|||    .   . || |  ||   ||. |||||||                           ||.|| .  ..|.  .  . . |   |   .||   ..
knrpagplapshtrvkl..qrvm.edl.gsdyina...........................rmiwetnasvivvlGdtddknnfwpekedyqlhpavil

DEFEVDNM--AEDAID-----QDFLVRTLKVTHKGASRIIY---QYHYHAWPDHGVPARPGSVMRL
 |.  | .    | ..      . |.    | |.  . .      .|| .||. |||  |  | .|
Gewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhvghl

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 51-145 1.3e-09 32.5 In-house 3-80 (130) alignment
Range on Protein: 51-145
Range on HMM: 3-80/130.0
IPYDFNRVVlttqrsededisGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDrfkcaKYWPNLHEFDVFDE
......|.             | .||||| |   .    .. .| ||  |  |||.|. |. | ..|.   . |.|     .|||.   .. ..|
lefevsrlq............gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePlewyee

0044763 (Phosphotyrosine protein) phosphatases II 52-285 1.5e-32 108.0 In-house 1-168 (178) alignment
Range on Protein: 52-285
Range on HMM: 1-168/178.0
PYDFNRVVLTTQrsedEDISGSDYINASSVEHGesqcRFIASQGPlphtlDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEfdvfdefevdnm
|.|..||.|..     |.. .||||||| . .|     ...|..|      |....|.| ... .|. .. .|. ..|| .|||  ..            
pldrtrvllsnl....eglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag............

aedaidqdflvrtlkvthkgasriiYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPsDQAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMlkqmglda
                         .||..  .||||||  .  ....... .| .. ..  | ..||||||||.| .      |.......        
.........................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlv.....aaylmkkl........

pCFDIFQVVWFLRQHRPaMVQTEDQYVFVYKAIL
  ....... ..|..|| .|....|. ..|.  |
.glsleeaielvrerRp.ivpnpgqlrqLyefel

0051429 (Phosphotyrosine protein) phosphatases II 70-290 1.4e-44 148.1 In-house 1-227 (272) alignment
Range on Protein: 70-290
Range on HMM: 1-227/272.0
ISGSDYINASSVEHGesqC------RFIASQGPLPHTLDDFWRMlWEKDVRIVVMACNIFENDRFKCAKYWP--NLHEFDVFDEFEVDN--------MAE
.. |.||||. |      .      |...|.||||.| .||||. .| ... .|. .. .| .|.|| .|||  ... ....|. . .         . .
lplsgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtlls

DAIDQDFLVRTLKVT---HKGASRIIYQYHYHAWPDHGVPARPgsVMRLIAAFRErqpsdqAAPLVIHCSAGVGRTGhfllgTICAIDIVWsmlKQMGLD
  .  |...|.| .|   . |..| ....||..|||||||  .  . .|......        |...|||||..|||     |..|....     ...|.
eellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTG.....tvvalllll...lgvsle

APCFD-------IFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
. . |       ....|  ||..||..||||.||.|.|.|.|.|.  
tivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrs

0046846 (Phosphotyrosine protein) phosphatases II 71-288 2.8e-42 139.7 In-house 10-173 (176) alignment
Range on Protein: 71-288
Range on HMM: 10-173/176.0
SGSDYINASSVEHGesqcRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVfdefevdnmaedaidqdflvrtlkvthk
 ..|||||. .  .    |.|| |||||.|| ||..||.| ....||. .. .| .|.||. ||| |.....                            
ldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

gasriiyQYHYHAWPDHGVPARpGSVMRLIAAFRERQPSDqaAPLVIHCSAGVGRTghfllGTICAIDIVWSmlkqmgldAPCFDIFQVVWFLRQHRP-A
       ||... |||||||     ...|... ||.. ..   | ..|||||.|||     ||..|......          ........ ..|..||  
.......qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRt.....gtlvaayllel........ekglsveealalvreqRplg

MVQTEDQYVFVYKAILDLV
.|||..|| |.|...| | 
avqtpeQyrflyefellll

0036282 (Phosphotyrosine protein) phosphatases II 72-282 4.5e-43 142.3 In-house 1-164 (174) alignment
Range on Protein: 72-282
Range on HMM: 1-164/174.0
GSDYINASSVEHGESQCRFIASQGPLPhtlddFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNlhefdvfdefevdnmaedaidqdflvrtlkvTHKG
|||||||| .   .   |.||.||||.     ||.||.| ....||| .. .|....||  |||                                ... 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

ASRIIYQYHYHAWPDHGVPARPGsVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKqmgldAPCFDIFQVVWFLRQHRPAMV
 .| ..||.|  |||||||  .  . ... . .| . .|.  |...|||||||||     ||..|....  .|.      .  |....|  ||..|| ||
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRt.....Gtlvaaylmlrgll.....eslvdaldlvrelRlqrpgmv

QTEDQYVFVYK
||..|| |.|.
qtpsQyrflyy

0043147 (Phosphotyrosine protein) phosphatases II 72-281 7.7e-42 138.3 In-house 4-154 (172) alignment
Range on Protein: 72-281
Range on HMM: 4-154/172.0
GSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIfendrfkcakywpnlhefdvfdefevdnmaedaidqdflvrtlKVTHKG
|||||||| ..     .|||| ||||..||.||||||.|......|....                                             .. ..
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpel

ASRIIYQYHYHAWPDHGVPaRPGSVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTGhfllgTICAIDIVWsmlKQMgldapcfDIFQVVWFLRQHRPAMV
 .| ..||.|. |||||||  .  .....   .|..  ..  | ..||||||||||     |..|.....   ...       .....| ..|..|| .|
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtg.....tlvaaylml...lgl.......sleeavalvrekRpgav

QTEDQYVFVY
|...|| |.|
qnpsqyrfly

0051082 (Phosphotyrosine protein) phosphatases II 73-284 4.2e-33 109.4 In-house 3-149 (151) alignment
Range on Protein: 73-284
Range on HMM: 3-149/151.0
SDYINASSVEHGesqcrFIASQGPLPhtldDFWRMLWEKDVRIVVMACNIFENDrfKCAKYWPNLHefdvfdefevdnmaedaidqdflvrtlkvthkga
|||||.| |. |     ...|.|||.    ||...|.| ... .|. .. .|..  .|..|.|.|                                   
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

sRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRErqpsDQAAPLVIHCSAGVGRTGHFLLGTICAIDivwsmlkqmgldapcFDIFQVVWFLRQHRPAMVQ
 . ....... |||.|.|  . .|.... ....    ..  |...|||||.|||| . .  ... .               ....... ..|..|| .||
.ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg...............vsleealeeyrlkrpgvvq

TEDQYVFVYKAI
...|..|...|.
pnqqflfqlfal

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 73-296 1.1e-19 65.7 In-house 46-267 (290) alignment
Range on Protein: 73-296
Range on HMM: 46-267/290.0
SDYINASSVEHGESQcRFIASQGPLPHT-------LDDFWRMLWEKDVRIVVMACNIFENDRF----KCAKYWPNLHEFD-VFDEFEVDNmAEDAIDQDF
.||| |. |   . . |.|..| |. ..       . .|| |  .  |. ||| |.  |...      |||| |.  . .  |. ..|    .   ..|.
ddyiHAnrvtcpngl.rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC.kskekeddv

LVRTLKVTHKGASRI-IYQYHYHAWPDHGVPARPGSVMRLIAAFRerqpsDQAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGLDapcFDIFQV
 .|.| |.. .     .  . .. | .  |.  . ... ||   .      . .| ..||  |. |       .. ||.. . .. ..  .   . . .|
etRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk.....asktpvivHcvdGiSrsA.....alaaiilgyQkiaetsgs...vkledv

VWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVLASMD
.  ||..|  ..... .. ||  .|. |...|| .. 
lkalrkqralaitsalelafvdagivllaievldqfa

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 86-282 9.3e-18 59.1 In-house 3-198 (199) alignment
Range on Protein: 86-282
Range on HMM: 3-198/199.0
SQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEF-DVFDEFEVDNMAEdAIDQDF----LVRTLKVTHKGASRIIYQYH
.| |.||.| || .|. |||.|.||     .||  .   |     . |||  .     .  . |   .  .   |.    |. | ..|   ..| | .| 
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttkti.ttkpdytitaliltnnttappstreishyq

YHAWPDHGVPARPGSVMrLIAAFRE---RQPSDQAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQmgLDAPCFDIFQVVWFLRQHRPAMVQTEDQY
. .| ..  |     |  .. | ||   .   .. ||...||| | | || |.     |.||     ..    .   |.|.|   ||| |  .. . ..|
ftswkekttpnvalfvg.fvvasrevskkyeqekdapvivhcsdgqgftgvfv.....aldigvrshee..sktsvvdlfevakrlrqarcgiisslqhy

VFVYK
 |.|.
nfiyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 86-282 1.1e-17 58.9 In-house 2-197 (198) alignment
Range on Protein: 86-282
Range on HMM: 2-197/198.0
SQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEF-DVFDEFEVDNMAEdAIDQDF----LVRTLKVTHKGASRIIYQYH
.| |.||.| || .|| |||.|.||     .||  .   |     . |||  .     .  . |   .  .   |.    |. | ..|   ..| | .| 
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttkti.ttkpdytitaliltnnttappstreishyq

YHAWPDHGVPARPGSVMrLIAAFRE---RQPSDQAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQmgLDAPCFDIFQVVWFLRQHRPAMVQTEDQY
. .| ..  |     |  .. | ||   .   .. ||...||| | | || |.     |.||     ..    .   |.|.|   ||| |  .. . ..|
ftswkekttpnvalfvg.fvvasrevskkyeqekdapvivhcsdgqgftgvfv.....aldigvrshee..sktsvvdlfevakrlrqarcgiisslqhy

VFVYK
 |.|.
nfiyq

0049260 (Phosphotyrosine protein) phosphatases II 88-282 2.6e-38 126.4 In-house 9-144 (152) alignment
Range on Protein: 88-282
Range on HMM: 9-144/152.0
CRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWpnlhefdvfdefevdnmaedaidqdflvrtlkvthkgasriiyQYHYHAWPDH
 .||| |||.|.||.||||||.| .....|| .. .|....||..|.                                           ||... ||||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qylhlpwpDh

GVPARPGSVMRLIAAFRERqPSDQAAPLVIHCSAGVGRTGhfllgTICAIDIVWsmlkqmgldaPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYK
|||  .  .. |. . ...   |.  | ..||||||||||     |..|.....            ......| ..|..|| .|....|. |.|.
gvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtg.....tlvaaylml..........lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 88-170 4.4e-07 23.6 In-house 236-314 (440) alignment
Range on Protein: 88-170
Range on HMM: 236-314/440.0
CRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIfeNDRfKCAKYWPNLHEFDVFDEFEVDNMAEDAIDQdFLVRTLKVTHK
  |||.| ||  |. ||||.. .  .  ..|  ..  ||.  |. |||       |  | |     . ...   ||||.. .|
nafiatqmpldstvldfwrlvhdyristiimlnql..ndk.tcsiywpvntrsvtfgpftvghkgsenmnr.vkvrtlelkyk

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 96-282 2.6e-17 57.2 In-house 99-282 (302) alignment
Range on Protein: 96-282
Range on HMM: 99-282/302.0
PLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPN-LHEFDVFDEFEVD------NMAEDAIDQDFLVRTLKVTHKG----ASRIIYQYHYHAW
|   ||. .| .. . .| |||  |.. |..  |||.|. . . .   | .. |       ...| .  ..| . |.... .       . .   .. ||
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHGVPARPGSVMRLIaAFRERQpsdqAAPLVIHCSAGVGRTGhfllgTICAIDIVWsmlkQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYK
|||| |. . . . ..  | |         ...||||||||||     |. ||        |. .     |. ..|  .|| |   ||.|.| ...  
pdhGapkeaytaldil.kfcesy....kknvlvhcsaGvGrtG.....tlvaikyGi....qlcskkkvtdllsivlpvrqcryGavqdeqqliylll

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 97-289 2.4e-19 64.4 In-house 39-222 (255) alignment
Range on Protein: 97-289
Range on HMM: 39-222/255.0
LphTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNlhEFDVFDEFEVDNMAEDAIDQDFLVRTLKVTH----KGASRIIYQYHYHAWPDHGVPAR
|  |.| |....  ..   ||| |.  |... || .|.|   | |    ..  |..     .| ..|||..|     |   . .  |.|. |...  |  
l..tvdkfyqtivqtktevvvmlcdfaeegvekcssyfpl..ekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPel

PGSVMRLIAAFRErqpSdqaAPLVIHCSAGVGRTGHFLlgticAIDIVWS-MLKQMGL-DAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
.  .. .. . |.   |    ..|.|||.|.||.  |       ...|.  |....   ..  .|  ...  ||..|.. ..|  |  |    .|||| 
areilnilkvvrd...s...ksvvvhCstGiGrsaafv.....laelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvf

subfamily_hpo-7_pd Subfamily hpo-7 97-296 8.6e-18 59.2 In-house 43-235 (263) alignment
Range on Protein: 97-296
Range on HMM: 43-235/263.0
LPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNlhEFDVFDEFEVDNMAEDAIDQDFLVRTLKVTH----KGASRIIYQYHYHAWPDHGVPAR
|  |.| |....  .    ||| |.  |... || .|.|   | |    ..  |..   . .| |..||...     |   . . .| |  |...  |  
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPl..ekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpel

PGSVMRLIAAFRERQpsdqaaPLVIHCSAGVGRTGHFLLgticaIDIVWS-MLKQMGL-DAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
. ...... . |. .      .||.|||.|.||.  | .     ...|.  |....   ..  .|  ...  ||..|.. ..|  |  |    .||.| .
areilnilkvarnsk......slvvhcstGiGrsaafsv.....aElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvln

VLASMD
  |  .
nfakge

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 101-289 1.4e-07 24.5 In-house 131-310 (346) alignment
Range on Protein: 101-289
Range on HMM: 131-310/346.0
LDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDNMAEDaIDQDFLVRTLKVTHKGAS-RIIYQYHYHA-WPDHGVPARPGSVMR
..||| |........| .            . .  .   ..    . ..|   | .  |    |..|  .| |  .| | |.|| |     | .   ...
vedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrrad.vsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlpiik

LIAAFRERQPSdQAAPLVIHCSAGVGRTGHFlLGTICAIDIVwsmlkQMGLDApcfDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
.|  |   .   |.| . .    | ||.  | .|.. ||. .     . |..    .|....  ..| ||  |..  ||  .|  ..| . 
mihqflsekqv.qnagvcvvslfgcgracsf.igalyainql.....nngiep...niceimknikqqrpggvesfaqyasiyaivfdyia

0048179 (Phosphotyrosine protein) phosphatases II 154-282 1.8e-21 71.8 In-house 48-139 (144) alignment
Range on Protein: 154-282
Range on HMM: 48-139/144.0
DaidqdflvrtlkvthkgasriIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDqaAPLVIHCSAGVGRTghfllGTICAIDIVWsmlkqmgldAPC
                      ..||..  |||||||  .  . .......| ....   | ..|||||||||     ||..|.....            
e.....................giqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRt.....gtlvaaylmk.........klg

FDIFQVVWFLRQHRPAMVQTEDQYVFVYK
....... ..|..|| .|....|. |...
lsleealalvrsrrpgavpnpgqlrfLle

0038934 (Phosphotyrosine protein) phosphatases II 160-283 6.9e-09 31.1 In-house 45-172 (194) alignment
Range on Protein: 160-283
Range on HMM: 45-172/194.0
FLVRTLKVTHKGASRII------------------YQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTGHFllgticaidIVW
.||| ||  ...   .|                  ..|.   .||.|..     ..| . .  |    |.    ..|| ||.|||| .         .. 
dlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtl.........vaa

SMLKQMgldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKA
 ... .     ...  . . ..|. || .... |..  ..| 
YLiyrl.....gmsaeeAialfrekRpgaipnqdyleallkr

0048076 (Phosphotyrosine protein) phosphatases II 161-286 2.7e-23 77.7 In-house 32-141 (145) alignment
Range on Protein: 161-286
Range on HMM: 32-141/145.0
LVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDqaAPLVIHCSAGVGRTGHFLlgticAIDIVWSmlkqmgldaPCFDIFQVV
.| .|  . .. .| ..||.|  |||||||  .  ....... .| ....   | ..|||||||||| .      |......           .......
tvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlv.....aaylmll.........lgvsleeal

WFLRQHRPAMVQTEDQYVFVYKAILD
 ..|..|| .|....|. |.|...| 
elvrsqrpgavpnpgqlrflyefele

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 172-287 1.5e-18 61.6 In-house 213-343 (350) alignment
Range on Protein: 172-287
Range on HMM: 213-343/350.0
ASRIIYQYHYHAWPDHGVPARPGSVMRLIA---------AFRERQPSDQAAPLVIHCSAGVGRTGHFL-----LGTICAIDIVWSMLKQMGLDAPCFD-I
   ..|| ... |.| ..  .| |... .            ..   .....|...|||||||||| ..     |  .  .. .    ...   |  .| |
dPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDli

FQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
...|  ||. |  |||. ||..|.|.|.| .
siivnelrkqrismvqnldqfifiYeallfy

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 172-287 1.8e-12 41.2 In-house 216-343 (349) alignment
Range on Protein: 172-287
Range on HMM: 216-343/349.0
ASRIIYQYHYHAWPDHGVPARPGSVMRLIAA---------FRERQPSDQAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLK-------QMGLDAPCFD
   ...|  .  |.| ..   | |... .            |    .|| ..|..||||| ||||     ... .|.. |.|.       .. | |  .|
kPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtG.....vlvtldlllsileplqnesnkiklqallkD

-IFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
 |. .|  ||. | .|||   |....|.|.|  
lisiivnelrkqrismvqnlaqfiaiyealLky

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 173-287 5.3e-22 72.7 In-house 88-193 (440) alignment
Range on Protein: 173-287
Range on HMM: 88-193/440.0
SRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQ
|| . ||||..|||.|||   | |...|    | |     .||..|||||.||||      | |.| .    |.    .   ||| ..  .|. || |||
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtg.....viiavdsilreakr....sdqidifsfinsmrnnrpqmvq

TEDQYVFVYKAILDL
| .||.||..|.|. 
tpeqyafvheavleg

PTPc_DSPc_SM00012 176-285 5.9e-32 105.4 In-house 2-104 (105) alignment
Range on Protein: 176-285
Range on HMM: 2-104/105.0
IYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQ-AAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGldaPCFDIFQVVWFLRQHRPAMVQTE
...|||..||||||| .. |...|..|... .   . ..|.|.||||||||||     |..|.||....|..      ..||||.|. ||..|| |||||
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtg.....tfvaldillqqleket...kevdifqivkelrkqRpgmvqte

DQYVFVYKAIL
.||.|.|.|.|
eqylflyrall

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 201-288 1.5e-10 35.4 In-house 219-295 (297) alignment
Range on Protein: 201-288
Range on HMM: 219-295/297.0
AAFRERQPsdQAAPLVIHCSAGVGRTGHFLLGticaiDIVWSMLKQMGLdaPcfDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
 ..|  .|  . |.|..||||||||.|  .|      |.. ..|..  .  |  |.  .. .||. |. .||| .|. ..|.|.|  .
eslraemp..rnayllvhcsaGvGrsGvvvls.....dvilaklrkkri..p..dvaailsilreqrarlvqtleqfellydavlkkl

subfamily_CG42327_pd Subfamily CG42327 210-286 4.8e-14 46.7 In-house 245-313 (319) alignment
Range on Protein: 210-286
Range on HMM: 245-313/319.0
DQAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQmglDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
..  |||.||| ||||||     .. | ||    |..        || |.| ..|. |   |.| .|| |.|| .  
esqGPlvvhcsdGvGrtG.....lviasdiairslee...skrsvdiPqlvssvrrdrasavltkeqyefiykvlse

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 215-286 7.1e-11 36.3 In-house 1-63 (69) alignment
Range on Protein: 215-286
Range on HMM: 1-63/69.0
LVIHCSAGVGRTGHFLlgticAIDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
.|.|||.| |||| |.     || .  . .|   |     |||  | ..|. || ||  | .|.|.. |. .
mvvhcssgtgrtgtfi.....aimvemariksekl....vdifnnvqymrkcrpmmvmneieyifihdalve

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 216-286 2.5e-10 34.6 In-house 1-62 (69) alignment
Range on Protein: 216-286
Range on HMM: 1-62/69.0
VIHCSAGVGRTGHFLlgticAIDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
|.|||.| |||| |.     || .  . .|   |     |||  | ..|. || ||  |..|.|.. |. .
vvhcssGtGrtGtfi.....aimvemariksekl....vdifnnvqymrkcrpmmvmneneymfihdalve

subfamily_ptpA1_pd Subfamily ptpA1 254-292 1.7e-07 25.3 In-house 364-402 (418) alignment
Range on Protein: 254-292
Range on HMM: 364-402/418.0
FDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVL
|..| .|  ||..|| |||  .||.|.||.||| . . |
fnlfsivlklreqrpgmvqqleqylfcyktildeiyhrl