Gene PTPN12 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN12
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP064_AA protein Get Run
MbreP064_AA_3-289 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN6_pd Subfamily PTPN6 3-290 1.9e-80 265.2 In-house 18-299 (306) alignment 
Range on Protein: 3-290
Range on HMM: 18-299/306.0
KSDQQDALEGFGAEFQRLRDMTaaYKASTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTtqrseDEDISGSDYINASSVE--HGESQCRFIASQGPLPHT
|.... . .||  ||..|. .    |   ||.||. .. |.||||| |.|.| .||.|.     .....|||||||. ..    .|....||.|| |..|
keeeslekagfeeefeelqqee..akkllsrkegakpenkeknryknilPfDhtrvilk.....epsvpgsdyinanyikkevkgsdksyiatqgclett

LDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDNMAEdAIDQDFLVRTLKVTH---KGASRIIYQYHYHAWPDHGVPARPGSVM
. |||||.|... |..||. .  |  . |||.|||. .| . . . .| |..|    .|. .|.|.|..   |. .| ..|||...|||||||. || |.
vsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavL

RLIAAFRERQPSDQ---AAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQMGLDAPcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
 ..   ...| . .   | |.|.|||||.|||| |.      |||. ..... ||||. .|| ..|  .|..|  .||||.|| ||||||   ...
dfledvnrkqeeleeaeagpivvhCsaGiGRtGtfi.....viDillkliekkgldad.idiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 3-287 2.6e-63 209.2 In-house 26-292 (319) alignment 
Range on Protein: 3-287
Range on HMM: 26-292/319.0
KSDQQDALEGFGAEFQRLRDMTAAykaSTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSededISGSDYINASSVEHGESQCRFIASQGPLPHTLD
||| .| |  . .||.|. ....     . ..     . | |||. .|...| |.| |         . .||||||| |.   .. ..||.||||. ||.
ksdfdddltklevefrracklgvn...ladqtfanldqnkdknriinilafdknvvklerliG....eefsdyinasfvtGyqrkdkyiaaqGPldntla

DFWRMLWEKDVRIVVMACnifendRFKCAKYWPNLHEFdVFDEFEVDnMAEDAIDQDFLVRTLKVTHKG---ASRIIYQYHYHAWPDHGVPARPGSVMRL
|||||.|| ..  .|.        . ||..|||.  .    ..|.|. .      ... || ......|     | | |.|.  |||.|||  |  .|||
dfWrmiweyncstivllt......kdkcsqywplkivi.keerfkvk.vdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrl

IAAFRE-RQPSDQAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD--L
.   |  ..  .. |..|.|||||||||| ..     ..|.. ...|.        |....|  ||| |. .||   || |.| |.|.  |
vkkvrhltskenhranivvhcsaGvGrtGvyi.....vldvlldrmke....ekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
0036941 (Phosphotyrosine protein) phosphatases II 4-289 1.7e-83 275.6 In-house 6-278 (297) alignment 
Range on Protein: 4-289
Range on HMM: 6-278/297.0
SDQQDALEGFGAEFQRLRDMTAaykaSTSREEGTTMHTKRKNRYKDIIPYDFNRVVLttqrsedEDiSGSDYINASSVEHGESQCRFIASQGPLPHTLDD
..... | ..  ||..| .. .    . |.. .    .. |||||||.|||..||.|       .| .|||||||| |.  . . .||| |||||.|..|
lekllflalllkefeellplll....lgslsvallpenleknRykdilpydhtRVkl.......dd.egsdYinAsyvdgydlkrkfIatqgPlpntved

FWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNL-HEFDVFDEFEVDNMAEDAI-DQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMRL
||||.|| .|...|| .. .|..| |||.|||.   |. ....| | .. .. . ..|. .|||.||.  .| ||.....||. |||||||  | |....
FWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldf

IAAFRERQPSD-QAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMgLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
| ..|....   .  | ..||||||||.|     |..|.|.....|..  |  ...||...| .||..|| .|||..||.|.| |.|.|..
ielvrkvlkllpsggpvlVHCsaGvgRsg.....tfiaadlmlqqledk.lkeggvdileavkklReqRpgavqtleqyrflyeallellk
0047943 (Phosphotyrosine protein) phosphatases II 4-287 1.1e-82 272.9 In-house 5-271 (273) alignment 
Range on Protein: 4-287
Range on HMM: 5-271/273.0
SDQQDALEGFGAEFQRLRDMTAaykaSTSREEGTTMHTKRKNRYKDIIPYDFNRVVLttqrsedeDISGSDYINASSVEHGESQCRFIASQGPLPHTLDD
 .... | .. .||..|....     . ... .   . | |||||||.||| .||.|        . .|||||||| |.  ... .||| |||||.|..|
lekllgltllleefelllslkp....lltysvallpenkdknrykdilpydhsrvkl........gdggsdyinAsyvdgynlkrkfiatqgPlpntved

FWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHE--FDVFDEFEVDNMAEDAiDQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMRL
||||.||..||..|| ....|..| |||.|||.  .  . ....| | .. |.  ..|. ||||..|.   | ||.....||. |||||||. . |....
fwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllef

IAAFRERQPSD-QAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
| . |. . .. .  | |.|||||||||     ||..|.|.....|.  |    ..|....| .||..|| ||||..||.|.|.|.|..
ielvrkalealpsngpvvVHCsaGvgRt.....gtfialdllldqlekeg....gvdvleavkllrsqRpgmvqtpeqyrflyealley
0045450 (Phosphotyrosine protein) phosphatases II 4-288 1.2e-80 266.9 In-house 20-304 (307) alignment 
Range on Protein: 4-288
Range on HMM: 20-304/307.0
SDQQDALEGFGAEFQRLRDMTAAYkaSTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEdedISGSDYINASSV--------EHGESQCRFIASQG
 ...| |.|. .||..|...|  .  . .....   . | |||||||.||| .||.|..  ..   ...||||||| |        .   .. .||| ||
lllldfltgllkefekllsvtvfl..lgeysiallpenkdknrykdilpydhtRVklssldgs...ledsdYiNAsyvrvpllllldgydlkrkfIatqg

PLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVT---HKGASRIIYQYHYHAWPDHGVPAR
|||.|..||||||||..|...|| .. .|..| |||.|||.  |. ....| | .. |.  .... ||||.||    .| ||.....||..|||||||  
PlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpps

PGSVMRLIAAFRERQPSD-QAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGLDAPcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
. .. ..| . |. . .. .  | ..||||||||||     |..|.......|.. |     .|....| .||..|| .||...||.|.|.|.|.|.
feelldfieevrkaleelpkggpvlVHCsaGvgRtG.....tfiaaylmlrqlekegtlld.vdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Ptp69D_pd Subfamily Ptp69D 4-289 6.3e-69 227.4 In-house 15-287 (307) alignment 
Range on Protein: 4-289
Range on HMM: 15-287/307.0
SDQQDALEGFGAEFQRLRDMTAAYKASTSREEGTTMhtkrKNRYKDIIPYDFNRVVLTTQRSEDEdisgSDYINASSVEHGESQCRFIASQGPLPHTLDD
| ..|. .|.  |...|   .   ....| ..  ..    ||||.||...| .||.|..   ...    ||||||| ..  . . .|||.|.|.  |..|
srkrdtdfglakeyekLeareidkstkvsekkenal....knRyedikafDktRvkLkkingked....sdYinasfikgykekkkfiaaqdPveatigD

FWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLhEFDVFDEFEVDnMAEDAIDQDFLVRTLKVTHKG-------ASRIIYQYHYHAWPDHGVPARPGSV
||||..|..| ..||  |. | .| |||||||.  .   ...  |. ...    .|.  |.|.|..|.       .|| . |||| .|.|  ||  . ..
fWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvk.lvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargl

MRLIAAFRERQPSDqAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
..||   || .  .  .|.|.||||||||.| |.     |.|...  ||.      . |||..|  ||..|. .||  .||||.|.|.||  .
lklieqvrelykln.rsPivvhCsaGvgrsgifv.....aldsllqqlka....edkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 4-292 1.2e-68 226.3 In-house 8-280 (281) alignment 
Range on Protein: 4-292
Range on HMM: 8-280/281.0
SDQQDALEGFGAEFQRLRDMTAAYKASTSREEgttmHTKRKNRYKDIIPYDFNRVVLTTQRSEDedisGSDYINASSVEHGESQCRFIASQGPLPHTLDD
. .|.  .||  |.. |...     |. |...    . . ||||..|. ||  ||..| . ..      .|||||. |.  ... ..||.|||.|..|..
qlsqndnaGfieeyeklaaigvdntataskad....envlknrYsnivaYDatrvkvtpneenk....ntDYinanfvpgykgekeyiatqgPvPaslva

FWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDNMAEDAiDQDFLVRTLKV-THKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAA
||.|.||..|...||  .  |... || .|||. ..   . .. | ..|| .  . .. |..|. ...| .| . | .| ||||||||| .  ..   ..
fWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeee.katyierkfkleresgetreveqlaytaWPdhGvPattkellefrke

FRERQPSDQAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQMgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVL
 .. . ... ||||||||||||||| ..     |.| . . ....   ..  |. .||  ||..|  ||||  || |||||.|| ... |
vlkltekktkaplvihCsaGvGrtGtyi.....alDrlvkaveae...leeldvkavvaelrkernlmvqtvvqyefvykavldaldkel
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 4-290 5.5e-55 181.4 In-house 13-280 (287) alignment 
Range on Protein: 4-290
Range on HMM: 13-280/287.0
SDQQDALEGFGAEFQRLRDMTAAYKASTSreeGTTMHTKRKNRYKDIIPYDFNRVVLTtqrsededISGSDYINASSVEHGESQCRFIASQGPLPHTLDD
....   |||   |. | ..|   .  |    . . . | |||...|...| .||.|             |||||. ..  ... .||....|. .|. .
kghakgnegfknqftvleqvtqredevth...niasqnkdknRltqilvpdnyrvllk........gehpdyinavfidgykekkafiiaesPmfntarn

FWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEfDVFDEFEVDNMAEDaIDQDFLVRTLKVTHKG---ASRIIYQYHYHAWPDHG-VPARPGSVMRL
||...... | ..|| |.  |||. .| .|||. .   |. |...  . |. . .....|.|.|..|.   . . . ||.. .|...| |.    ... .
fWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvi

IAAFReRQPSDQAAPLVIHCSAGVGRTGHFllgtiCAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
   ..  |     ...|.|||..|||.. |     ||...     |. |      |.|||.   |. .| .||| .|| |.....|  .. 
eemyk.tqrkrgntsivvhCsdtvGrsamf.....caaattinkckteG....viDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_PTPN12_pd Subfamily PTPN12 5-297 1.2e-128 423.1 In-house 2-286 (290) alignment 
Range on Protein: 5-297
Range on HMM: 2-286/290.0
DQQDALEGFGAEFQRLRDMTAAYKAST--SREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDedisGSDYINASSVEHGESQCRFIASQGPLPHTLD
..... | | .|||.|......|||..  |.|.|.......|||||||.|||..||.|.....|.    |||||||......|.....||.|||||.|||
eekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeee....gsdYinanfikgvegkleyiaaqgPLpktld

DFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDV-FDEFEVDNMAEDAIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIA
|||||.|||.|.||||||...|....||..|||. .| .. |.||||....|.|.|.|||.|||||.....||..||.||.||||||||... |...||.
dfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelie

AFRERQPsDQAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKQmGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVLASMDN
..||.|  ...||||.|||||||||     |||.|||.|...||. .  ....|.|..|. ||..|.|.|||..||..||||...|||. |.....
lvrelqe.sedaPlvvhCsaGvGrt.....Gtiiaidyvrellka.ekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiiee
0050432 (Phosphotyrosine protein) phosphatases II 5-291 7.7e-88 290.1 In-house 36-302 (308) alignment 
Range on Protein: 5-291
Range on HMM: 36-302/308.0
DQQDALEGFGAEFQRLRDMTAaykaSTSREEGTTMHTKRKNRYKDIIPYDFNRVVLttqrsedeDiSGSDYINASSVEHG--ESQCRFIASQGPLPHTLD
.... | .. .||..|....     . ... .     | |||||||.||| .||.|        | .|||||||| |      ....||| |||||.|..
ekaldlglleeefeellsvkp....lleysvallpenkdkNrykdilpydhsRVkl........d.egsdYInAsyvdgyssklprkfIatqgPlpntve

DFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNL--HEFDVFDEFEVDNMAEDAiDQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMR
|||||.|| .||..|| ....||.| |||.|||.   ... ... | | .. |.  ..|. ||||..|.  .| ||.....||..|||||||  | ....
dFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilld

LIAAFRERQpsdQAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKQMgldaPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQV
.. . |...   .  | |.|||||||||     ||..|.|.....|..      ..|.|..| .||..|| ||||..||.|.|.|.|.... .
flelvrksl...pggpivVHCsaGvGRt.....Gtfialdllleqleke....ggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 5-289 1.7e-73 242.5 In-house 21-291 (298) alignment 
Range on Protein: 5-289
Range on HMM: 21-291/298.0
DQQDALEGFGAEFQRLRDMTAAYKAStSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRsEDEDisgSDYINASSVEHGESQCRFIASQGPLPHTLDDF
...  | |. .|||||. ..   ..  . | . . . |.|||| |||..|. ||||...  .||.   ||||||| ..  . .  |||.|.||..|. ||
kkkkkltgyalefqrlnsvsseieee.ekevarkpenkkkNRyadiialdssRvvLeked.adee...sdYiNAsflhaykgrnafiatqaPltetvedF

WRMLWEKDVRIVVMACNIFENDRFKCAKYWPNlHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVTHKG--ASRIIYQYHYHAWPDHGVPARPGSVMRLIAA
|||..|.|.  .||  |. | |. |. ||||. .. . ..|..|. ....    |. ||.|||..|    .| . | |.  |||.|||.   ||. |.. 
WrmvteedigtiVmltnleeldktkyhkywPd.egketygeitvsllskee.fadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrk

FRERQPSDQAAPLVIHCSAGVGRTGHFllgtiCAIDivwSMLKQMGLDApCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
 |  |     .|....|||||||.| |     .|||   |.| ..  .    |.||||  ||..||..||||.||||.|.|.|. ..
vrasqqqagnkpvivqCsaGvgRsGtf.....iaid...svlervkkeq.vvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
0039614 (Phosphotyrosine protein) phosphatases II 6-290 6.3e-83 273.9 In-house 27-291 (297) alignment 
Range on Protein: 6-290
Range on HMM: 27-291/297.0
QQDALEGFGAEFQRLRDMTAaykastSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEdisGSDYINASSVEHGES-QCRFIASQGPLPHTLDDF
...   .. .||..| ...       .....     | |||||||.|||..||.|.. .. |.   .||||||| |.  .  . .|||.|||||.|..||
kansktllllefeellslkp......dysiallpenkdknrykdilpydhsrvklkpedgvdl...dsdYinAsyvdgydlltrkfIatqgPlpetvedF

WRMLWEKDVRIVVMACNIFENDRfKCAKYWPNLHEfdVFDEFEVDNMAEDAiDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFR
|||.|| .|...|| .. .|..| |||.|||.  .  ....| | .. ..  .... ||||.||..| ||......|. |||||||  . ...... . |
wrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkveh.ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvr

ERQPSD-QAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKQMgldaPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
|.. .. .  | ..|||||||||     ||..|.......|.       ..|....| .||..|| .|||..||.|.|.|.|.|...
ealaelpkggpvlVHCsaGvgRt.....Gtfiaaylmleqleke....ggvdvleavkelreqRpgavqtpsqyrflydallellkr
subfamily_PTPRB_pd Subfamily PTPRB 6-290 3.2e-78 257.7 In-house 20-287 (293) alignment 
Range on Protein: 6-290
Range on HMM: 20-287/293.0
QQDALEGFGAEFQRLRDMTAAYKASTSReegtTMHTKRKNRYKDIIPYDFNRVVLTTQrsedEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFW
..|.  .|  |...|...    . ....    ..  . ||||..|.||| .|| |..     .| ||||||||. ..  .|.  |||.|||||.|.||||
kadsdlrfseeyeelkavgkdqavkaae....lavnraknrytnilpydhsrvkLaal....kdesgsDYinanyipgynsprefiatqGPlpetvddfW

RMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDNMAEDAIdQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRE
||.||| ..|.||  ...|. . || .|||. .|  .. . .|. .||.   .|. .|.||.... ..| . |||. .||||||| .. ...... ..||
rmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeel.edwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvre

RQ-PSDQAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
..  . ...|.|.|||||||||| |.     |.| . . ...      . ||| .|  ||..|  .||||.||.|.....|||...
aiektaskrPivvhCsaGvGRtGtfi.....aldrllqaiee....edyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 6-288 2e-57 189.8 In-house 19-288 (325) alignment 
Range on Protein: 6-288
Range on HMM: 19-288/325.0
QQDAlEGFGAEFQRLRDMTAAYKASTsreegTTMHTKRKNRYKDIIPYDFNRVVLTTQRsedeDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFW
 ||  .||  ||. |    .  |  .     .  . | |||.|.....| .|||| |..    | . ||||||| ..    .  |.|.| ||..|..|.|
aqdq.dgfahefgllpsddgiakkva.....mkpenkaknrfknvvaldksrvvletkk....ddpssdyinasylrddkkkdvflaaqaPltatindlW

RML--WEkdvRIVVMACNIFENDRFKCAKYWPNL-HEFDVFDEFEVDNMAEDAIdQDFLVRTLKV--THKGASRIIYQYHYHAWPDHGVPARPGSV---M
|..  |.     ||.  |.....  .||.|||.   .   |  .||  .. . |  |.. | |.|  ..|| .| . |... .|.| ||. || ..   .
rlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisil

RLIAAFRERQPS--DQAAPLVIHCSAGVGRTGHFLlgticAidiVWSMLKQMGLDApCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
.|. |  ||  .    ..|...|||||||||| |.     .   ..|.|...  ..   |||..|  ||..||.||.| |||...|.|. . .
qlvkavservtantkastpilvhcsaGvGrtGvfi.....s...lysalakviees.rvdifgfvkklrkdrpsmvetvdqyiliyealveay
0051299 (Phosphotyrosine protein) phosphatases II 7-288 5.5e-86 283.9 In-house 19-286 (288) alignment 
Range on Protein: 7-288
Range on HMM: 19-286/288.0
QDALEGFGAEFQRLRDMTAAykasTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSededISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWR
.. | |. .||..|.....      ..  .   . . ||||.||.||| .||.|..  .    ..|||||||| ..  .....||| |||||.|..||||
angltglleefeellsllpd....ltlsaallpenleknRysdilpydhsRVkLsvldg....vegsdYinAsyidgynlkrkfIatqgPlpntvedFWr

MLWEKDVRIVVMACNIFENDRFKCAKYWPNlHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVT------HKGASRIIYQYHYHAWPDHGVPARPGSVMRLI
|.||..||..|| ....|..| |||.|||. ... ..... | .. |.  ..|. ||||.||       .| ||.....||..|||||||  | ......
mvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldfl

AAFRERQPsDQAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMgldaPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
 ..|. .. ..  | |.||||||||||     |..|.|.....|..      ..|....| .||..|| ||||..||.|||.|.|...
rlvrkala.sgggpvvVHCsaGvgRtg.....tfialdllleqleke....ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPN23_pd Subfamily PTPN23 7-292 8.6e-60 197.0 In-house 11-284 (288) alignment 
Range on Protein: 7-292
Range on HMM: 11-284/288.0
QDALEGFGAEFQRLRDMTAAYKASTSReeGTTMHTKRKNRYKDIIPYDFNRVVLTtqrsededISGSDYINASSVEHGESQC-RFIASQGPLPHTLDDFW
 |   .....|. |..  ..   ..|           |||..||.||| |||.|          |  |||||| |..  ..|  |||.|.||. || |||
ldgktaldkkfkeleqkqdkearkrsi..aiaklyseknrsrdilPyDhnRvklr........gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFW

RMLWEKDVRIVVMACNIFENDRFKCAKYWPN-LHEFDVFDEFEVDNMAEDAIdQDFLVRTLKVTHKGAS--RIIYQYHYHAWPDHGVPARPGSVMRLIAA
.|..|. ....||  .  | .. |...|||.   |  .|....|    .    . .  |.||.....|.  . .   ....||..|||| |....... .
lmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvret.ethvervlkletldadavksvshlqltsWpelGvPasPetllqflde

FRE---RQPSDQAAPLVIHCSAGVGRTGHFLLGtICAIDIVwsmLKQMGLDapcfDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVL
 ..    .     .|||.|||||||||| | |  ..|.  .    |. ||     || |||  ||. |  |||...|. |.|.|.|  ...||
vesayeavqrksktPlvvhCsaGvgRtgvfalv.yaavrel...ekgngll....diiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 7-291 6.2e-59 194.2 In-house 16-286 (290) alignment 
Range on Protein: 7-291
Range on HMM: 16-286/290.0
QDALEGFGAEFQRLRDmtaaYKASTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTtQRSEDEDISgSDYINASSVEHGESQCRFIASQGPLPHTLDDFWR
.   ||| ..|..|       . . . . |.|   |..||...|..|| ||..|  . |...| .  .||||. ..  . . ..|| |||...|| |||.
akgnegfrnqfkmlds....gesehtvtvgltssnkllnRfanivvyddnritLr.pisghkDCt.neyinAcyikgykekkqyiatqgpvsntlvdFWk

MLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDvFDEFEVDNMAEDAIDqDFLVRTLKVTHKGA---SRIIYQYHYHAWPDHG-VPARPGSVMrLIAA
..|...| |.|| .|| |... || .|||.    . ..||..  . | ... ..  |.|.|..| .   .... ||.  .|...| |... .... .|. 
liwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtill.viee

FRERQPSDQAAPLVIHCSAGVGRTGHFllgtiCAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQV
  . |  .   ..|.|||..|||.. |     ||...     |. |      |.|||.  .|. .| .|||..|| .... .|  ....
myktqrkrgntsivvHCSdtvgrsavf.....caaattinkckteg....vidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 8-290 1.7e-71 235.6 In-house 18-281 (288) alignment 
Range on Protein: 8-290
Range on HMM: 18-281/288.0
DALEGFGAEFQRLrdmtAAYKASTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQrsedEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRM
.. .||  |.. |    || . . | . |   . ..||||..|.|||..|| |.      |. .|.|||||| ..  ... ..||.||||..|..|||..
rnrtgfseeynsL....aalektksvtagrlavnakknRyrnilpyDekrvklkkl....eeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

LWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDnMAEDAIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQ
 .|...  .||  .. |... || .|||. ..   . ...|  . |.   .||..|.| . .|.  . | ||.| ||||||||.    .. |.      .
vyenktstivmltelveggktkCeeYWPdadkpknyGsvtvt.lveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvan

PSDqAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
..| . |...|||||||||| |.     |.| .  ....        |.. .|  ||..|. .|||. ||.|.|...|.|...
qad.tgpiivhCsaGvGrtgtFi.....aldalidavee....edyiDvagtvaklRkqRallvqtlkqYefiyevllsliee
subfamily_PTPRG_pd Subfamily PTPRG 9-300 3.1e-66 218.8 In-house 17-299 (563) alignment 
Range on Protein: 9-300
Range on HMM: 17-299/563.0
ALEGFGAEFQRLRDMTAAykASTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEDIsgsDYINASSVEHGESQCRFIASQGPLPHTLDDFWRML
.  || .||. |   |..   .   |     . |||||| .|..||  || |.    .....   |||||. ..  . .  |||.||||..|.||||||.
gdigfseefealqsetis..kdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl...DYinAnyidGyqkskafiatqgplkdtfddFWrmi

WEKDVRIVVMACNIFENDRFKCAKYWPNlHEFDVFDEFEVDNMAEDAI----DQDFLVRTLKVTHKGA---SRIIYQYHYHAWPDHGVPARPGSVMRLIA
||. | |.||  |. |. | ||  |||.  |   .....|  ..|. .     . . .. ||. .|      . ..||||  |||||||  .  |.  . 
WeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvk

AFrERQPSDQAAPLVIHCSAGVGRTGHFllgtiCAIDivwSMLKQMGlDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVLASMDNSAL
   ..   ..| |.|.|||||||||| .     ...|   ..|||.  .    ..|...  .| .|. .||||.||.|...|.|....     . .. .
ks.saankaeaGPivvHcsaGvgrtGty.....ivld...tllkqiq.qenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqv
0043336 (Phosphotyrosine protein) phosphatases II 10-287 1.9e-80 265.6 In-house 19-276 (278) alignment 
Range on Protein: 10-287
Range on HMM: 19-276/278.0
LEGFGAEFQRLRDMTAaykasTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTqrseDEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLW
  .. .||..|....       ... .  .. | |||||||.|||..||.|.     ..   .||||||| |.  . . .|||.|||||.|..|||||.|
ktllllefeellsfkl.....dtysiallpenkdknrykdilpydhsrvklsl....lggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvw

EKDVRIVVMACNIFENDRFKCAKYWPnlHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVT--HKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQ
| .|...|| .. .|..| |||.|||   .. ....| | .. |.  ..|. ||||.||   .| ||....|||..|||||||  . ...... |.||..
elgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal

PsDQAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
. |.  |...|||||||||     ||..|.......|.  |    ..|....| .||..|| .|||..||.|.|.|.|..
e.dsngpvlVHCsaGvgRT.....Gtfialyllleqlekeg....gvdleeavkelreqRpgavqtpsqyrflyealley
0040438 (Phosphotyrosine protein) phosphatases II 11-293 6.4e-84 277.2 In-house 18-281 (317) alignment 
Range on Protein: 11-293
Range on HMM: 18-281/317.0
EGFGAEFQRLRDMtaayKAStSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTqrseDEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWE
 ..  ||..|...    | . .....     | ||||.||.|||..||.|.     .. . .||||||| |.  . . .||| |||||.|..|||||.||
talleefedllsl....kld.tysvaelpenkdknrypdilpydhsRVkLsp....lggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvwe

KDVRIVVMACNIFENDRFKCAKYWPNlHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQP
 .|...|| .. .|..| |||.|||.  |. ....| | .. |.  .... .|||.|..  .. ||.....||..|||||||  | .. ... | || ..
qgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale

sDQAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVLA
 |.  |...|||||||||     ||..|.......|.. |    ..|....| .||..|| .|||..||.|.|.|.|.... .| 
.dpggpvlVHCsaGvgRt.....Gtfiaaylmleqlekeg....gvdveeavkelreqRpgavqtpeqyrflydalleylkrklt
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 11-290 8.7e-70 230.3 In-house 23-285 (319) alignment 
Range on Protein: 11-290
Range on HMM: 23-285/319.0
EGFGAEFQRLRDMTAAykastSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQrsedEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWE
 ..  ||. |.  ..      . .. .. . |.||||..|..||  ||||..     ... |||||||| ..  . . .||| |.|| .|..|||||.||
tllekefkllkeavnd.....tfdsaskeenkkknryqnilaydrtrvvlsel....dgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWe

KDVRIVVMACNIFENDRFKCAKYWPNLhEFDVFDEFEVDNMAEDAiDQDFLVRTLKVTHKGA---SRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQ
... |||| ... |. . |. ||||.  .| .. .. |.   |.   .|. .| ||. .| .   .| . ...| .||||.|| .  |.. |.   |. .
eessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeee.ledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksr

PSDQAAPLVIHCSAGVGRTGHFllgtiCAIDIvwsMLKQMGLDApCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
   |. |.|.|||||||||| |     ...|.   || .. ...   |.|..|  ||  |. |||...|| |.|.|.|. |. 
ektqsgPivvhCsaGvGRtGtf.....ivlda...mlervkeeg.vlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
subfamily_PTPN9_pd Subfamily PTPN9 11-289 4.5e-62 204.7 In-house 16-291 (297) alignment 
Range on Protein: 11-289
Range on HMM: 16-291/297.0
EGFGAEFQRLRDMTAAYKASTSREEGttmhTKRKNRYKDIIPYDFNRVVLTTQrSEDEdisGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWE
.|   |.. .|..... .. .|.  .      .||||.|.. ||  ||||... .|||    ||||||. |.  . .  ||| ||||..| .|||||.||
rGlskeyaeirnepveGtflasklra....nleknrytdvlcydetrvvlakv.dede...asdyinanfvdGykqkkafiatqGplkktvsdfWrmvWe

KDVRIVVMACNIFENDRFKCAKYWP-NLHEFDVFDEFEVDNMaEDAIDQDFLVRTLKVT--HKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQ
..|...||.  . |. | ||..||| . .. . | ...| |. |.   .|. ||.|...  ... || .  . . .|||.|||    |.. .. . ||.|
qevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnv.eveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekq

PSD------------QAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
 .             .  |.|.|||||.||||     | ...||  | |...|      |....|  ||. |  ..||..||.| |.|.|.  .
alavkelgdewkghpsgPPivvhcsaGiGrtG.....tfitldiclsrleevg....tvdvvetvkllrtqrafsiqtpeqyefcylavleyal
subfamily_CG7180_pd Subfamily CG7180 11-288 5.4e-48 158.1 In-house 13-290 (296) alignment 
Range on Protein: 11-288
Range on HMM: 13-290/296.0
EGFGAEFQRLRDMTAAYKASTSREeGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEdisgSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWE
. | .|.. .  .|.  .  . .  |   . . |||. ...|||.|||||..   |..    ||||||. |.    .  .|  ..|  .|.|.|||....
rkfrveyklelkltprleigdCag.glrkenreknrdvkvvPyDynRvvLekldGeek....sdYinavyvdsflkkkeyivteapkketvdefWrlvyd

KDVRIVVMACNIFENDRfKCAKYWPNLHeFDVFDEFEVDNMAEDAIdQDFLVRTLKVTHK------------GASRIIYQYHYHAWPD-HGVPARPG---
...  ||. .. |.  . .. .||||      . |..|. . |.    ..  ||.|.|.|               ||. ....  |.  . ||       
eeisavvvLtktfdfak.mypsywpnks.keqygeifveiveekqy.anlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnali

SVMRLIAAFRERQ-PSDQAAPLVIHCSAGVGRTGHFllgtiCAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
 ..| .  .||.    .. .|.|...| |..|.| .     .|||.   .... .    ..|.|. |  ||..|| .|.. ..| ..|  .|. |
elrrrvrlwrekvdedpeegPvvvvssdGasRsGvy.....laidanlelvekee....evdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 11-288 1.3e-45 150.7 In-house 20-279 (439) alignment 
Range on Protein: 11-288
Range on HMM: 20-279/439.0
EGFGAEFQRLRDMTAAYKASTSREegTTMHTKRKNRYKDIIPYDFNRVVLTtqrsEDEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWE
| |  .|. .  .   |.. .|    .  . . ||||||. ..|. ||.|     |   .  | ||||  ..    .  .||.|||  .| |||||...|
eifkeifekinstspdyaciasla..aqeydqtknrykdvgafdhtrvtlq....eipgvphshyinanyikGyyddklyiatqgpkkettddfwrlvie

KDVRIVVMACNIFENdrFKcakYWPNLHEFdVFDEFEVDnmAEDAI-DQDFLVRTLKVTHKG----ASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRE
| .  .|| .|..|   .|   |||   |  .. .  |   ..  |   .. .| .||  .       | . |.|| ||||. |||.   |. .. |   
kktvtivmltnlves..yk...ywpsdaev.cygdiavr..vdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrains

RQPSDQAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKqmgLDApCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
 . ...  |.|.||||||||||     || |.||    ||   |.    ||  .| .||..|  |||.  ||||.|.|.|. .
andkeeygpvvvhcsagvGrtG.....tiialdialeqlk...len.kvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 12-290 1.1e-33 111.3 In-house 23-289 (305) alignment 
Range on Protein: 12-290
Range on HMM: 23-289/305.0
GFGAEFQRLRDMTAAYKASTSREegttMHTKRKNRYKDIIPYDFNRVVLTTQRSededisgSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEK
|. |||. .. .    |  . .|       . ||||||.   | ||| | .           .|| |  |       ||| .| || .|  ||| | ...
glraefvamkrfndfekmkafke....aqeagknrykdvgcldnnrvklegpwp.......heyihanyvstptnpkrfictqaplektcadfwymclqd

DVRIVVMACNIFENDRFKCAKYWPNLHE-FDVFDE--------FEVDNMAEDAIDQDFLVRTLKVTHKGA---SRIIYQYHYHAWPDHGVPARPGSVMRL
 |  . | ||. |    ||..|..  ..    |.|        ||  .  .   | .  |.  ... .|.   .| . .||.  ||| ||||   ... |
kveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailel

IAAFRerqPSdqAAPLVIHCSAGVGRTGHFLLgticaIDIVwsmLKQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
..  |   ||    |.|.|||||.||||  ..     .. .   |.|.       |  ...  .|. |   .||..||.||.. ||. ...
lekar...ps..kgpivvhcsagigrtgsvvm.....leyi...ldqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
0046845 (Phosphotyrosine protein) phosphatases II 13-290 5.2e-86 283.8 In-house 2-276 (284) alignment 
Range on Protein: 13-290
Range on HMM: 2-276/284.0
FGAEFQRLRDMTAAYKasTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTtqrSEDEDISGSDYINASSVEHG-----ESQCRFIASQGPLPHTLDDFWRM
. .||..|. .|  .    |.. .   . . |||||||.||| .||.|.   |.|.|...||||||| |.        ....||| |||||.|..|||||
leeefeellsltvkll..lslsvallpenlsknRykdilpydhsRVklk...sldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrm

LWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVTH---KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFR
.||..||..|| ....||.| |||.|||. .|. ....| | .. |.  ..|. ||||..|.   .| ||.....||..|||||||. | ...... . |
vweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvr

ERQPS-DQAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKQMGLDaPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
| ... ..  | |.|||||||||     ||..|.|.....|.. ||.  ..|....| .||..|| ||||..||.|||.|.|.... 
ellenlpgggpivVHCsaGvgRt.....Gtfialdllleqlekegll.lgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 13-297 9.5e-79 259.7 In-house 22-289 (318) alignment 
Range on Protein: 13-297
Range on HMM: 22-289/318.0
FGAEFQRLRDMTAAYKASTSreegTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEdediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKD
. .|..||   ..   .  |    ..   |.|||| .|..||  || |... .|     |||||||. ..  ...  .||.|.|||.|..|||||.||..
lseeyerlsrseetvtslks....lepvnkaknryanilaydhtrvkLqmlege....egsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqn

VRIVVMACNIFENDRFKCAKYWPNLHEfDVFDEFEVDnMAEDAIDQDFLVRTLKVTHKG--ASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSD
 ...||  .. |. . |...|||.      ...  |. . |.   .|...|..|||...  .||.. |||| .|||.|||. ..|.. |.   .. | . 
savivmltqeeergkakvhryWPskgs.rsygklvve.lkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqks

QAAPLVIHCSAGVGRTGHFllgtiCAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVLASMDN
.| |.|.|||||||||| |     .|.||.   .|. .      |.||.|  ||..|..||||||||.|.|...|. ..   . .| 
gagpivvhCsaGvGrtGvf.....iavdillerikaea....lvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevda
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 13-288 6.7e-65 214.0 In-house 21-277 (315) alignment 
Range on Protein: 13-288
Range on HMM: 21-277/315.0
FGAEFQRLRDMTaAYKASTSREEgttmHTKRKNRYKDIIPYDFNRVVLTTQrsedEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKD
|  ||. | |   .|.  ..||.       .|||||.|.|.| .||.|       .|.  ||||||| ..  ...  .|||||||. ..||||||.....
fseefhdlpdPd.iyrqrvaret....infkknryknilPldsarvklevi....ddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqek

VRIVVMACNIFENDRFKCAKYWPN-LHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERqPSDQ
|  .||  .  |.|. ||..|||.   .   | ...|. .  .| | |  .| | . .  .|| . |.... |||.||. . .|...|| . .      .
vttivmvtkkqegdkikcrqywPdrkadsvefGsikvellslea.dtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkk

AAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
  .|..||||||||||      ...|| | . .|.    .   |.|..|  ||..|| .||||..| |.| |.|. .
efsllvhcsaGvGrtG.....vvisidevvaqikr....trsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 13-292 3.6e-34 113.0 In-house 8-263 (267) alignment 
Range on Protein: 13-292
Range on HMM: 8-263/267.0
FGAEFQRLRDMTAAyKASTSreEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEdedisgsdYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKD
.  ||. .. ..   ..  |     ... . .||. | .||| .||.| |.  |        ||||| ||  . .  ||. |.||  |  ||. .. ...
iekefelikkisdt.sstis..qsiaeknqernrlddnlpyddtrvilrtkeee........yinasyvegyktknafivtqdplkntitdfltvihdqk

VRIVVMACNIFENDRFKcaKYWPNLHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVTHKGAS-RIIYQYHYHAWPDHgVPARPgSVMRLIAAFRERQPSDQ
| ..|.  ..|...  .   . |.. .   .... |.   |   ..|. . ||..  |  | . .  |.|. |    .  .|  .  |.. . . |  . 
vpvivlltkvftdnirl..fwPPkmgqakkyqdltvehsleke.endyqiitlelkfknesahnvtlyyykkwnin.tnnkp.ylkplfgilaknqleng

AAPLVIHCSAGVGRTGHFLlgticaidIVWSMLKQMGLDApCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVL
  |||..||.||||.| ||        .. |.|...  .    |||. .  .|. |...|.| ..|..... . .  .  |
nrPlvvacsdGvGrsGtfl........vidsqlerakteg.vsdifdflrkirsqriglvdtkeryiyihellaeyaegrl
DSPc_SM00195 15-288 5.8e-82 270.3 In-house 4-262 (263) alignment 
Range on Protein: 15-288
Range on HMM: 4-262/263.0
AEFQRLRDMTAAYkastSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEdediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVR
.||..|...|       . .|.   . |.|||||.|.||| .|| |... ..    .|||||||. ..  ... ..|| |||||.|..||||| ||..|.
eefekleestspk....etteaekkknksknRyknilpydhtrVklkkeekk....egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvk

IVVMACNIFENDRFKCAKYWPNL-HEFDVFDEFEVDNMAEDAIDQDFLVRTLKVTHKG--ASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDq
|.|| .. .||.. ||..|||.  ..  .|....| .. ..  .... .|||..|..|   .| ..||.|..|||||||  . ||..|. |..... .  
iivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.

AAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
 .|.|.||||||||||     |...|||..| |..       .|||..|  ||..|| ||||..|| |.|.|||...
sgpivVhCsaGvgRtg.....tfvtidiilskleeekk....vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 15-288 5.8e-82 270.3 In-house 4-262 (263) alignment 
Range on Protein: 15-288
Range on HMM: 4-262/263.0
AEFQRLRDMTAAYkastSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEdediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVR
.||..|...|       . .|.   . |.|||||.|.||| .|| |... ..    .|||||||. ..  ... ..|| |||||.|..||||| ||..|.
eefekleestspk....etteaekkknksknRyknilpydhtrVklkkeekk....egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvk

IVVMACNIFENDRFKCAKYWPNL-HEFDVFDEFEVDNMAEDAIDQDFLVRTLKVTHKG--ASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDq
|.|| .. .||.. ||..|||.  ..  .|....| .. ..  .... .|||..|..|   .| ..||.|..|||||||  . ||..|. |..... .  
iivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.

AAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
 .|.|.||||||||||     |...|||..| |..       .|||..|  ||..|| ||||..|| |.|.|||...
sgpivVhCsaGvgRtg.....tfvtidiilskleeekk....vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN13_pd Subfamily PTPN13 15-291 7.5e-66 217.2 In-house 15-272 (273) alignment 
Range on Protein: 15-291
Range on HMM: 15-272/273.0
AEFQRLRDMTAAYKAstsrEEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSededisgsdYINASSV--EHGESQCRFIASQGPLPHTLDDFWRMLWEKD
 ||. ||.. .  ..    |.| . . |.||||....|||  || |  . .         ||||| .  . |. . ..||.|||||.| .|||.|.||..
eefkelrelkpldtc....evgkkkenkdknryrnvlPydetrvklgdegg.........yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqk

VRIVVMACNIFENDRFKCAKYWPNLHE--FDVFDEFEVDNMAEDAIDqDFLVRTLKVTHK--GASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQP
.....|  .  |... || .|||. ..    | . .||...     | .| ||.|.|...  |.|| . . .. .|||||||. . ......|  |. | 
aeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkld.gfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt

sdQAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQV
  .|.|.|.|||||.||.|     |. .||.|  ....       ||. ..|  ||. | ..|||.|||.|||||||......
..dagPivvhcsaGiGrsG.....tlitidvvlglierdk....efdvkeivrklreqrqgvvqtkdqyifvykailevlksl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 15-285 2.2e-51 169.4 In-house 14-274 (287) alignment 
Range on Protein: 15-285
Range on HMM: 14-274/287.0
AEFQRLRDM----TAAYKASTSREEgttmhtKRKNRYKDIIPYDFNRVVLTTQRSedediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWE
.|...|..     || .||..   .       .|||| |..|.| .||.|...        |||||||  |   . . .|||.|||.. |. ||||...|
kevdalkedsesstatfkaaeelaa......vkknryadvlPiddtrvllsaege.....lGsdyinanyvasytddeafiaaqgPiaatvrdfwravle

KDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDNMAEDAIDQDFLVRTLKVTHKGAS--RIIYQYHYHAWPDHGVPARPGSVMRLIAAF----R
. .  |..     |. | || ||||. .       . |  .  |  . .. ||.|.. .  .   |.. |... .|||....    ...|..        
trsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhie

ERQPSDQAAPLVIHCSAGVGRTGHFLLGTICAidivwsmlkQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAIL
 .. .... |||.|...|.||.| .|   ..          ....|    |. .|| .||..| |.||.  |. ..|.|. 
lardasevGPlvvhddvGiGrsGillatlvlv.........srledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 15-286 6e-48 158.2 In-house 24-234 (392) alignment 
Range on Protein: 15-286
Range on HMM: 24-234/392.0
AEFQRLRDMTAaYKASTSREEgttmHTKRKNRYKDIIPYDFNRVVLTTQrsedEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVR
 ||. | .  . |. .....|      ..|||||.|.||| .||.|       .||. |||.||| ..  ...  .|||||| . .|||||||.....| 
eefhdlpgpdi.ypqtvaqke....inlkknryknilpydsarvklevi....ddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvt

IVVMACNIFENDrfkcakywpnlhefdvfdefevdnmaedaidqdflvrtlkvthKGA-SRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRErQPSDQAA
 ..|  .. | |                                           ||   | . |.|.  |||..|| .  |....|   .  .  . . 
tiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtssllkfikevka.dfGqyth

PLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
||.|||||||||||      . .|| | .  |.  .     |.|..|  .|..|| ||||..|| |.| |.|.
pliihcsagvgrtg.....vvisidsvvahakktrm....vdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_PTPN14_pd Subfamily PTPN14 16-289 1.2e-51 170.5 In-house 28-297 (300) alignment 
Range on Protein: 16-289
Range on HMM: 28-297/300.0
EFQRLRDMTAAYKASTSREEgttmHTKRKNRYKDIIPYDFNRVVLTTQRSEdedisGSDYINASSVEH--GESQCRFIASQGPLPHTLDDFWRMLWEKDV
|..|.  . .  . ||.. .      ..|||.||..||. ||| |.... .      ..||||||..   | ..  .|..||||..|. |||.|.||..|
eyeripkkredallstaklp....enaeknrfkdvlPyednrvelsptken.....stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgv

RIVVMACNIFENDRFKCAKYWPNL---HEFDVFDEFEVDNMAEDAIdQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMRLI---AAFRE
...||  .. |. . |. ||.|.|   ..   |..|.| .   .   . .  ..||. |   .  | ..   |  |||||||  . . .  .    . |.
qlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfseds.dsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrr

RQ-----PSDQAAPLVIHCSAGVGRTGHFLLGticaiDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
.      . ..  |...||||||||||  .|      |.. . |..        || .|.  ||. |  .|||  || ||||...  ..
ktnseveskeskPPvlvhCsaGvGrtGvlils.....dlliatleh....neeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_PTPRN_pd Subfamily PTPRN 25-292 2.1e-54 179.3 In-house 39-296 (297) alignment 
Range on Protein: 25-292
Range on HMM: 39-296/297.0
AAYKASTSRE-EGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEdisgSDYINASSV-EHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNI
.||.|  | .  . . .. .|||.|...||| .|| |... |...    |||||||.. .|   .  .||.||||..|. |||.|.||. | ..|. ...
cayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaek....sdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrl

FENDRFKCAKYWPNlHEFDVFDEFEVDNMAEDAIDQDFLVRT--LKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRErQPSDQAAPLVIHCS
 |..  .|..|||. .  .|.. .||. ..|    .|.|||.  ||  ..  .| . |.|. .||..|||| . |.. .           ...|.|.|||
eeegvkqckrywpd.eGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnk.syrGrscpivvhcs

AGVGRTGHFllgtiCAIDIVwsmLKQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVL
.|.|||| .     ..||.|   |...   .   ||   .  ||. || .|.|.||. |...|. . |...|
dGaGrtGvy.....ilidlv...lnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevnail
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 27-291 8.6e-70 230.3 In-house 32-286 (305) alignment 
Range on Protein: 27-291
Range on HMM: 32-286/305.0
YKASTSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDedisGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFEND
|. ..| . |.. . |.|||.|.|...|..|. ||.. |.|     ||||||| |.  ... ..|..||||..|..||||...|  |. .|| ... |..
yeeeesidvgkkeankaknrlkeitlldddriiltekesld....dsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklvegg

RFKCAKYWPNLHEF-DVFDEFEVDnMAEDAIDQDFLVRTLKVTH---KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQAAPLVIHCSAG
. || .|||. .     |.||.|  . . .  .|.. | ||..    .  || . ||.   |||||||  ..|...||   ...| .|.  ||..|||||
kdkCrqYWpesktekkefgefsve.lksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsag

VGRTGHFllgtiCAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQV
||||| |     .|.||    ||. .      |.|.|.  ||..|. |||| |||||.. |. .|..  
vgRtGvf.....iavdialerlkkEe....vvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
subfamily_eak_pd Subfamily eak 27-191 2.9e-12 40.7 In-house 38-196 (332) alignment 
Range on Protein: 27-191
Range on HMM: 38-196/332.0
YKASTSREEGTTMHTKRKNrYKDIIPYDFNRVVLTTQRSEDEdisgsDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFEND
|.   | .|.. . . ..|   .|.|||.. | ||. . . .      ||||| .|  |   ..| .  .    .  ||.|. |.    .|.  .  |..
yqrllsisetarleavnrn.vvkivpydrylvrltssqlnrl.....GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelk

RFKCAKYWPNLH-EFDVFDEFEVDNMAEdaIDQD-FLVRTLKVTHKGASRIIYQYHYHAWPDHGVPA
  |  ||.|.   |   |  ..|.      . .. . .| |...    .  .. |... | .  .| 
leksdkyfpdktreelkfGildverkef..vkrniletrllelskGnethrvlhykvfGwtettlpk
subfamily_PTPRD_pd Subfamily PTPRD 30-297 1.5e-85 283.0 In-house 37-290 (564) alignment 
Range on Protein: 30-297
Range on HMM: 37-290/564.0
STSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEdediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFK
... |. .  . |.||||..|..|| .||||.. . .    .|||||||| ..  ...  .||.||||..|..|||||.||......||  .. |... |
qftweaankpaNkaKNRyanivaYdhsRVvLskvegd....egsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvk

CAKYWPNLHeFDVFDEFEVDNMAEDAIdQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQpSDQAAPLVIHCSAGVGRTG
|.||||. .    ..|..|. ..|  . .|. .||.|...  .  || . |.|. .|||||||  . |...||   |. . ...| |.|.||||||||||
chkYWPekg.tetygeltVtleeeeel.adyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTG

HFllgtiCAIDIvwsMLKQMGLdAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVLASMDN
 |     ..||.   ||...       ||.|.|. ||..|.||||||.||.|...|||. ..    ... 
tf.....ivida...mlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnteves
subfamily_PTPRA_pd Subfamily PTPRA 30-288 1.7e-69 229.2 In-house 47-295 (330) alignment 
Range on Protein: 30-288
Range on HMM: 47-295/330.0
STSREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEdisgSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFK
 .. |  .    |.|||. .|.||||.||.|.... ..|    ||||||| ..  . . .|||.|||. .|..|||||.||..   .||  .. | .. |
qatlelaskeenkeknrvvnilPydfsrvilsvkeGvee....sdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeek

CAKYWPNLHEF---DVFDEFEVDNMAEDAIDQDFLVRT-LKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQAaPLVIHCSAGVGR
||.|||.   .   ..  | | .....|   ..|||.   . |.. .||.. |.|...||| |||. |  ...|... .. ..     |.|.||||||||
caqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGr

TGhfllgTICAIDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
||     | ...| |  ..|  ..     |.|..|  ||. || ||||. ||.|.||..|.  
tG.....tfivldavlervkaerk....vdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 32-292 5.9e-65 214.1 In-house 19-272 (274) alignment 
Range on Protein: 32-292
Range on HMM: 19-272/274.0
SREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEDisgSDYINASSVEHG-ESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKC
..|| . . ...|||||.|.| .  ||.|... |||||   |.||||  .    | .  ..| |||||.|..|||||.....|...||  .. |... ||
dqeeldvfgsqtknryktilPnensrvllesesseded...ssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkC

AKYWPNLHEF---DVFDEFEVDNMAEdAIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQA--APLVIHCSAGVGR
|.|.|. ...   . ....|. .       .|. ||.| . .   .| .. | | .|||| .| .. ....|..  .| . ...|  || |.|||||.||
avyfPdaedyeiserygdveikveki.verndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGr

TGHFLlgticAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVL
|| |.     ||.|    |..        |....|  ||..|  ||||..|| ....|.   ....|
tGcfi.....aisiavrqlre....eivvdvlkivcnlrldrGGmvqtseqyelihralclylkrll
subfamily_ptpA1_pd Subfamily ptpA1 32-235 6e-43 142.1 In-house 38-252 (418) alignment 
Range on Protein: 32-235
Range on HMM: 38-252/418.0
SREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQrsedEDISGSDYINASSVEhGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCA
   ||   |   |||| .|.| .. || |       .|  |||||||  .. |    .||..||||| |. |||||.||. .||.||     || | || 
etsegdkkhntsknrytnilpvnhtrvqlkki....qdkegsdyinanyid.gaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcd

KYWPNLH---EF-------DVFDEFEVDNMA-EDAIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQ-----PSDQAAPL
.|||.     .|       .||  . |. .   .  ... . | ...| .| .| | ||.|  |||| .| .   . .|. .  .||      ||.  |.
rywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpi

VIHCSAGVGRTGHFLLGTIC
..|||||||||| |    | 
ivhcsagvgrtgtfctavim
0045098 (Phosphotyrosine protein) phosphatases II 33-290 4.4e-74 244.6 In-house 25-274 (278) alignment 
Range on Protein: 33-290
Range on HMM: 25-274/278.0
REEGTTMHTKRKNRYKDIIPYDFNRVVlttqrsededisgsDYINASSVEHGesQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAK
 ...     . |||||||.|||..||.              |||||| ..    . .||| |||||.|..|||||||| .....||... .|..| |||.
itpalylgnldknRykdilpydhsrVk..............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWPNlHEFDVFDEFEVDNMAEDAIdQDFLVRTLKVT------HKGASRIIYQYHYHAWPDHGVPARP--GSVMRLIAAFRERQP------------SDQA
|||. ... ....|.| .. |. . .|. .|||.||      . . || ....||. |||||||  |   |. .|.   ||..              |. 
ywpe.ggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg

APLVIHCSAGVGRTGHFllgtiCAIDIVWSMLkqmglDaPCFDIFQVVWFLRQHRPA-MVQTEDQYVFVYKAILDLVQQ
 | ..|||||||||| .     .|.... ..|     . . .|....| .||..||  .||...||.|.|...|.|...
gpvlVHCsaGvgRtGtl.....vaaylmlell.....e.ggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_PTPN1_pd Subfamily PTPN1 34-291 5.8e-61 200.7 In-house 25-274 (290) alignment 
Range on Protein: 34-291
Range on HMM: 25-274/290.0
EEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSededisgsDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKY
.|  . . . .|||.|. |||  |..|  .          |||||| ||  | . ..| .|||||.| | ||.|.||.. . |||  .. |... |||.|
reaklpenrnlnryrdvspydhsrikleradn........dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WPNLHE--FDVFD--EFEVDNMAEDAiDQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQ-PSDQAAPLVIHCSAGVGRT
||. .|    ...  ...|. ..|.   . . ||.|...      .| |...|| .||| |||  |.. ....   ||    |..  | |||||||.||.
wPqgeeekellledtklkvkliseer.ksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrs

GhfllgTICAIDIVWSMLKQMGlDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQV
|     |.| .| .   ... . |. . || .|.  ||..|  ..|| ||  | | |||. .. .
G.....tfclvdtclvliekkd.dlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvi
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 34-289 7.6e-49 161.0 In-house 33-294 (301) alignment 
Range on Protein: 34-289
Range on HMM: 33-294/301.0
EEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSedEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKY
. |.. . |. ||.|.| .|| ||..|.....   |..  .||||| ..   .. .|||.|||. .|| ||||..|.. .  .|| .|  |. . || .|
tvglseenkalnrfknitvyddnriilkpkpn..ldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqy

WPN-LHEFDVFDEFEVDnMAEDAIDQDFLVRTLK-----------------VTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQAAPL
|||  .| . | .|.|  . ....  ||..| |.                 |... .|. . |..   ||..||   |  |.. |     || .   .|.
wpnseaeseefgpftvt.lvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpv

VIHCSAGVGRTGHFllgtiCAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
|.|||..|.|.| .     |...|     |  |      |.|||.  .|. .| .|.| .||...|..|   .|
vVHCSdtVsrsGvY.....csvsiglEQckaeg....VVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 34-289 3.2e-26 86.8 In-house 35-277 (312) alignment 
Range on Protein: 34-289
Range on HMM: 35-277/312.0
EEG-TTMHTKRKNRYKDIIPYDFNRVVLTTqrseDEDIsgsdYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAK
 |  . .. |  ||| .|  .|  |  |.     ||..    || |  |       ||...||||  |   ||..        ... | . |.   ||||
sectaflkfkdlnrypniqcwdrgrftlag....denf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcak

YWPNL------HEFDVFDE----FEVDNMAEDAIDQDFLVRTLKVThkGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRErqpsdQAAPLVIHCSAG
|  ..       .  |. |     |.   . | | .  |   .| |  |    . .| . .|||||.|    . .||..| .      .  |.. |||||
yisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkat..gqesklnhyqwaswpdhgmpdscdtalrllsavkk.....dkkpviahcsag

VGRTGhfllgTICAIDIVWSMLKQMGlDAPCFDIFqvvWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
|||||     |.. |. . . |..        |.|    .||. |   |..  |||.. ...|... 
vgrtg.....tlaliesmiaalrhpr.kqnvkdsf...vllrkdrarsvrvfpqyvyalrcvlefly
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 34-95 1.5e-08 28.7 In-house 41-95 (95) alignment 
Range on Protein: 34-95
Range on HMM: 41-95/95.0
EEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSededisgSDYINASSVEHGESQCRFIASQG
  |..     |||. .|.|||  ||||||.|        ||||||  |.    .  .||.||
tvgsseanipknrflnifpydatrvvlttkrd.......sdyinacfvdgyarkncyiaaqg
subfamily_egg_pd Subfamily egg 35-296 2.7e-27 90.2 In-house 34-278 (307) alignment 
Range on Protein: 35-296
Range on HMM: 34-278/307.0
EGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEDisgsDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDrfKCAKYW
.  .   . | | | .   |. || |  .|    |    |.| |  |. .     || .| ||  | ||||||.....|. .||     |..  .|  ||
taasdnnlekarskrvhckdssrvklelrrGqyld....dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkese..rceyyw

PNLHE-FDVF--DEFEVDNMA-EDAIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIaafreRQpsdQAAPLVIHCSAGVGRTGhfl
|. ..   |.    ....|.  ... |  | |  ||.          ..    .   .    |  |.|..     |.    . | |...  || ...   
pkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdvysplrvlrkl.....rn...lskpvvvqdilGvskaa...

lgTICAIDIVW-SMLKqmGlDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVLASMD
  |. ||.|   |.|.  |     . . . | |||..|.  |..  .|.|||. .| ....|..|  
..tlvaieiallsllr..G.pitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsak
0040439 (Phosphotyrosine protein) phosphatases II 36-288 7.4e-74 243.8 In-house 6-246 (249) alignment 
Range on Protein: 36-288
Range on HMM: 6-246/249.0
GTTMHTKRKNRYKDIIPYDFNRVVLTTQRSededISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWP
.  .  | ||||.||.|||..||.|.  ..      .||||||| ..   .. |||| |||||.|..|||||||| .....||... .|..| |||.|||
allpenkdknrypdilpydhsrvklsilpg....lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

NlHEFDVFDEFEVDNMAEDAiDQDFLVRTLKVT--HKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSD-QAAPLVIHCSAGVGRTghfllG
.  .. ....| | .. ..   .|. ||||..|   .| || .....|. |||||||  . .....| | |. . .. .  |...|||||||||     |
l.ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRt.....G

TICAIDIVWSMLKQMgldaPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
|..|.......|.       ..|....| .||..|| .||...||.|.|.|.|.|.
tfiaaylmleqleke....lgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 36-288 2.6e-59 195.8 In-house 43-284 (297) alignment 
Range on Protein: 36-288
Range on HMM: 43-284/297.0
GTTMHTK---RKNRYKDIIPYDFNRVVLTTQRSEDEdisgSDYINASSVEHGESqcRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRfKCAK
.|. . |    |.|||.|.|||..|| |    .. .    |||.||| |.  .   |.|..| | . |..|||.|.....| ..||  .  |.|. |||.
qtvaekkvnfeksRYkniLPydssRvkLaivnddpd....sDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcar

YWPNLHEFDvFDEFEVDNMAEDAIdQDFLVRTLKVTHKG--ASRIIYQYHYHAWPDHGVPA--RPGSVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTGH
||..      | .  |  .. .   . |. |.|.||.    | |.. ||..  |||. |.   .  |.. ||   |.   . . .||..||.||||||| 
yWsdkgvtt.fGdvsvvllsvser.eGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgv

FllgtiCAIDIVWSMLKQMgldaPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
.     ..|| | .  |.        |||..|  |||.|| .|||..|| |||.|.|. .
l.....ltidsvvaeakre....kevdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 37-287 1.8e-60 199.9 In-house 21-256 (284) alignment 
Range on Protein: 37-287
Range on HMM: 21-256/284.0
TTMHTKRKNRYKDIIPYDFNRVVLTTQRSededISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACnifendRFKCAKYWPN
   . | |||. .|...| |.| |         . .||||||| ..   .. ..||.||||. ||.|||||.|| ..  .|.        . ||..|||.
nldqnkdknrighilafdknvvklerliG....eefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

LHEFdVFDEFEVDnMAEDAIDQDFLVRTLKVTHKG---ASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRE-RQPSDQAAPLVIHCSAGVGRTGHFLlg
  .    ..|.|. .      ... || ......|     | | |.|.  |||.|||  |  .|||.   |  ..  .. |..|.|||||||||| ..  
kivi.keerfkvk.vdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi..

ticAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD--L
   ..|.. ...|.        |....|  ||| |. .||   || |.| |.|.  |
...vldvlldrmke....ekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 37-291 3.2e-60 198.4 In-house 16-267 (270) alignment 
Range on Protein: 37-291
Range on HMM: 16-267/270.0
TTMHTKRKNRYKDIIPYDFNRVVLTTQRSedeDiSGSDYINASSVE-HGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWP
.. ..|. |||.||.|    ||.| . ..   | | . ||||  |.   ......||..|||| || .||||.||. |. .||. .. |. | ||..|||
eaargkklnRyadiLPsPatRvrleelee...d.sataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWp

NLHEFD-VFDEFEVDNMAED-AIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPG------SVMRLIAAFRE-RQPSDQAAPLVIHCSAGVGRT
.  .    . . ..  .|.  . .. .... |....|| .| .  ..|..||||||| ...      .......| |. ..  |.| ||..|||||||||
aepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRt

GhfllgTICAIDIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQV
|     |. |.||.  .|.. .      |. ...  ||..|.|.||. .|| |.|||..  ....
G.....tlialDiavrlLeetk....kvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 37-286 2.3e-46 152.9 In-house 29-264 (283) alignment 
Range on Protein: 37-286
Range on HMM: 29-264/283.0
TTMHTKRKNRYKDIIPYDFNRVVLTTQRSededisgsDYINASSVE---HGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKY
.. . |||||...|.|.| .|| | ..          |||||. .    . . . ..|..|.|| .|  |||.|......  .||  .. |. | ||..|
sadenkrknrnqeivpadqwrvelksesr........dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqy

WPNLHEFDvFDEFEVDnMAEDAIDQDFLVRTLKVTHKGA---SRIIYQYHYHAWPDHGVPARPGSVMRlIAAFRERQPSDQAAPLVIHCSAGVGRTGHFL
||.    | . || |  . ..   . | .. | . ....   . ..  | .  | . |  |   |... .   .  |   . .|.|.|||.|.|||. |.
WPkrGsed.yGeftvt.lrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvk.fnkvislqteskkgPivvhCstgiGrtavfi

lGTICAIDivwsmlkQMgLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
 .  ....       .. |     |.|.||  .|..|. .||| ||| .|....|.
.aasasvk.......da.ltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_CG42327_pd Subfamily CG42327 38-201 1.1e-25 84.9 In-house 25-188 (319) alignment 
Range on Protein: 38-201
Range on HMM: 25-188/319.0
TMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEDisgsDYINASSVE-HGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPN
 . .| |.|. ...|    ||||  . ..|.|     |..|| |  . .... .||.| .|  .  ||||..||.  |..| .....|.   .||.|.| 
PvtskdksrvinvvPlPetrvvlqrigdddkd....eyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPt

L---HEFDVFDEFEVDnMAEDAIDQDFLVRTL--KVTHKGASRIIYQYHYhAWPDHGVPARPGSVMRLIA
     . ... .. |  . . .... ... ||  |  .|  || .  | |  |.. .||| . ... .. 
ketldntslyGdilvt.lkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamll
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 39-289 3e-64 211.6 In-house 7-243 (250) alignment 
Range on Protein: 39-289
Range on HMM: 7-243/250.0
MHTKRKNRYKDIIPYDFNRVVLTTQRsEDEDisgSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFkCAKYWPNlH
.. | |||| |||..|  |||| ...  |..   ||||||| ..  . .  |||.||||..|. |||||..|...  .||  |. |...  . .|||   
pqnkeknryadiialdssrvvLekek.gdke...sdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv.e

EFDVFDEFEVDNMAEDAiDQDFLVRTLKVTHK--GASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTGHFllgtiCA
. . . .  |. . ..    |. .|.||....    .||. |.|. .||| |||.   .|. |.   .  |.  ..||....|||||||.| |     .|
kaekyGdvtvsllskee.fadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGaf.....ia

IDivwSMLKQMGLDApCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
||   ..|...  .    |.|.|.  ||..|| .|....||||||..||  ..
id...avlerlkkek.vvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_PTPN3_pd Subfamily PTPN3 39-290 6.8e-59 194.1 In-house 39-277 (280) alignment 
Range on Protein: 39-290
Range on HMM: 39-277/280.0
MHTKRKNRYKDIIPYDFNRVVLTTQRsededisgSDYINASSVEHG----ESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYW
 .   ||||.||.|||  || |. ..        .|||||. |.      .   |.||.||||..|  |||.|.||......||  .. |. | || .||
penlsknryrdilpydatrvklkese........tdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyW

PNLHEFDVFDEFEVDNMAEdAIDQDFLVRTLKVTHKG--ASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSdQAAPLVIHCSAGVGRTGHFLLg
|. ..   . ||.|    | . .. ...| | ...|    .| | |  | ||||||||  . ......   |. . . .  |.|.|||||.|||| ..| 
Petedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg.keePvvvhCsaGigrtGvlil.

ticaIDIVWSMLKQmglDAPcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
    ...  ... .     | . . ..|  .|. | ..|||..|| || .||| . ..
....letalaliea...aep.vypldivrtmrdqramlvqtasqykfvCeailkvyee
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 39-287 7.7e-57 187.6 In-house 47-278 (315) alignment 
Range on Protein: 39-287
Range on HMM: 47-278/315.0
MHTKRKNRYKDIIPYDFNRVVLTTQRSEdediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLh
.. |.|||| .||.||  || |     .    ..|||.||. ..  . . |.||.|||.. ...||||...|.|.  .||  |. |... |. ||||.  
ienkqknryiniiaydksrvqlpllend....phsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.

eFDVFDEFEVDNMAEDAiDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQpSDQAAPLVIHCSAGVGRTGHFllgtiCAID
   .. .. |  . |.   ... |||| |. .   | ..|.|| .||| |||.   ..| ||   .  .  ......|.|||||||||| |     ...|
.kviyGkitvtrkseev.nteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhh.tnsvgaivvhcsaGvGrtGtf.....itld

ivwSMLKQMGLDApCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
   ..|.|.  .    |.....  .|| |  |||. .|| |.|.|.|. 
...avldqaeaen.aidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 39-287 4e-34 113.0 In-house 41-270 (288) alignment 
Range on Protein: 39-287
Range on HMM: 41-270/288.0
MHTKRKNRYKDIIPYDFNRVVLTtqrsEDEDIsgsdYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLH
. .  ..||...   |. || |.    .| |     ||.|  |  .. . |.| .| ||  |.. .|.|| |.||. .|| |.. |  . | |.|.|   
ianptrdryenlprcditrvkls....ddpdf....yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl

-EFDVFDEF-EVDNMAEDAIDQDFLVRTLKVTHKGASRI-IYQYHYHAWPDHGVPARPGSVMRLIAAFrerqpSDQAAPLVIHCSAGVGRTGHFLLGTIC
 |   .  .  |     . ||.   | .|.....|  .. . . |.. |.|.|||    | .||.  .      .   |.|.|.|||||||| . |  | 
GekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililia

AidivwSMLKQMglDapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
.      .|.    |     | ...  ||..|   .||| ||..|.. .|. 
l.....eslrld..d..flgirsllaklreerfkaiqtemqylyvhrcvlee
0042113 (Phosphotyrosine protein) phosphatases II 40-288 2.5e-73 241.8 In-house 8-243 (245) alignment 
Range on Protein: 40-288
Range on HMM: 8-243/245.0
HTKRKNRYKDIIPYDFNRVVLTTqrseDEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNlHE
. | ||||.||.|||..||.|.     |.   .||||||| |   .   .|||.|||||.|..|||||||| .....|| .. .|..| |||.|||. .|
enkdknrysdilpydhtrvklsp....dggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge

FDVFDEFEVDNMAEDAiDQDFLVRTLKVT--HKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTghfllGTICAI
. ....| | .. |.  ..|. ||||.||   .. || ...|||. |||||||  . .. ... . |. . .|.  |...|||||||||     ||..|.
sltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRt.....Gtfiaa

DIVWSMLKQMGldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
......|.  .    .......| .||..|| .|||..||.|.|.|.|.|.
ylmleqlekel....gvsleeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 40-287 4.4e-70 231.3 In-house 9-241 (243) alignment 
Range on Protein: 40-287
Range on HMM: 9-241/243.0
HTKRKNRYKDIIPYDFNRVVLttqrsedediSGSDYINASSVEHGEsqcRFIASQGPLPHTLDD----FWRMLWEKDVRIVVMACNIFENDRFKCAKYWP
  . ||||.||.|||..||.|          .|||||||. ..  .   |.||.|||||.|..|    ||||||| .....|| .. .|..|.|||.|||
enlsknrysdilpydhsrvkl..........egsdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

nlHEFdVFDEFEVDNMAEDAIdQDFLVRTLKVTH---KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPS-------DQAAPLVIHCSAGVGR
   |. ....|.| .. |    .|. ||||....   .. .| ...|||..|||||||  | ...... . || . .       |.  |...||||||||
..gev.tygdftvtllseehl.ddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGhfllgTICAIDIVWSMLkqmgldapCFDIFQVVWFLRQHRPA-MVQTEDQYVFVYKAILDL
||     |..|.... ..|        ..|....| .||..||  .|||..||.|.|.|.| |
tG.....tliaaylmllll........gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPRK_pd Subfamily PTPRK 40-286 8.6e-63 207.0 In-house 42-275 (314) alignment 
Range on Protein: 40-286
Range on HMM: 42-275/314.0
HTKRKNRYKDIIPYDFNRVVLTTQRSEdediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHE
. ..|||..||..||  ||.|.|   .    . ||||||. ..  .    ||. ||||..|. ||||......   .||  .. |. |.|| ||||.  |
enreknrsgdilaydrsrvflitidgd....pssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedte

FdvFDEFEVDNMAEDaIDQDFLVRTLKVTH----KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSdQAAPLVIHCSAGVGRTGHFllgtiC
   .....|  .  . ......||...|..    . . |.. |... .||||.||    ....|..   . |.  .| ..|.||||| |||| |     .
v..ygdikvelvete.llaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtf.....i

AIDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
|||||  |... |.     |.|..|  ||.... ||.||.||.|.| .||.
aidivldmieregv....vdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 40-286 1.2e-52 173.5 In-house 2-237 (237) alignment 
Range on Protein: 40-286
Range on HMM: 2-237/237.0
HTKRKNRYKDIIPYDFNRVVLTTQRSEdedisgSDYINASSVEHGES-QCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLH
. | |||| .|. || .||||    |.      ||||||. ..  .    ..||.||||  . ||||.|.|..   ..||   . |... || ||||. .
enkiknrygnivaydhsrvvlkgagsg......sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd

EFDVFDEFEVDNMAEDAIdQDFLVRTLKVTHKGA---SRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPS-DQAAPLVIHCSAGVGRTGHFLLgti
.   .  . |    ....  |. ||.| .....     |.|.||.. .|||.||| .  ...|.     .| |   ...| .||||||||||| ||.   
qpaaygvltvslkkkeef.sdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflv...

caIDivwSMLKQMGlDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
  ||   .||.|   .    ||.. |. . . || ..||.|||||....||.
..id...amlrqak.ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0049772 (Phosphotyrosine protein) phosphatases II 40-290 5.1e-43 143.3 In-house 45-282 (314) alignment 
Range on Protein: 40-290
Range on HMM: 45-282/314.0
HTKRKNRYKDIIPYDfNRVVLTtqrseDEDISGSDYINASSVEHGesqCRFIASQGPLPHTLDDF----------WRML--WEKDVRIVVM---------
  . ||||.||.|.| |||.|       ...||||||||| |      ..|||.||||..|..||          |||   .. .||..||         
lnrdknryldilpad.nrvilp.....glpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------ACNIFENDRFKCAKYWPNLHefdvfdefevdnmaedaidqD-------FlvrtlkvthkgaSRIIYQYHYHAWPDHGVPaRPGSVMRL
             ... .|  . .|.....|.                    .       |            .| ...|... .||...|  .  . ..
lsrLdaAlgKtpllildgngneptaadlellk....................eelydpelf............erlgikylripvpDgsap.lledfdef

IAAFRERqpsDQAAPLVIHCSAGVGRTGHFLLGTICaidivwsmLKQMGldapcFDIFQVVWFLRQHRP-----AMVQTEDQYVFVYKAILDLVQQ
.....|    |.  |...||.||.|||| |..  ..        .|..|     ... ... ..|. ||      .... .||.|...|.|.... 
lefieea...dkggpvlvHCkaGkgRtgtfvvaayl........mkllg.....vsleealedvrlkRpinpnpgfieqleqyefilealleylkf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 40-287 1.8e-39 130.1 In-house 36-268 (281) alignment 
Range on Protein: 40-287
Range on HMM: 36-268/281.0
HTKRKNRYKDIIPYDFNRVVLTTQRSEDEdisGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWP-NLH
  ..|||| .|   |  || |  .  . .    .||| |  .     .  .| .|||   |  |||||.|...   .|| |.. | .| |||.|.| | |
vnnkknrylnipcldisrvqlkvkmpnkn...stdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah

EFDVFDEFEVDnMAEDAIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERqpsdqAAPLVIHCSAGVGRTGhfllgTICAID
    ||.. |.   . .... ..   |.....| .|.| .. .. |||  ||     .....   | |     ..| ||||||||||.|     |. |..
cclqfdklsvs.yedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar.....stppvihcsagvgrsg.....tlmave

IVWSMLKQmglDAPCFDIFQVVWFLRQ-HRPAMVQTEDQYVFVYKAILDL
|    ..         || |.|  ||   | | ||| .||....| .||.
ialqsihs...hftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 40-287 1.3e-37 124.1 In-house 54-288 (305) alignment 
Range on Protein: 40-287
Range on HMM: 54-288/305.0
HTKRKNRYKDIIPYDFNRVVLtTQRSededisGSDYINASSVEHG-ESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLH
 .. ||||.|.   | . | |  . |       |||| |  |      . |||..|||| .|.|.|| |. .. |  .|| |.  |  ..|||.|||  .
iaitknryqdvpcqdqsavkl.dkps......psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaq

--EFDVFDEFEVDNMAED-AI--DQDFLVRTLKVTHKGASRI-IYQYHYHAWPDHGVPARPGSVMRLIAAFRERQpsdqaAPLVIHCSAGVGRTGhfllg
    ..     |.|..    .  | .  . .|..|. |  .. . . ..  ||| |||    . . |..| |  .      |.|.|||||.||||     
geklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk.....vpivvhcsagigrtg.....

TICAIDIVwsmLKQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
|| ||. .   |...  . ||  . ..|  ||..|   .|.. ||.|... .|. 
tivaieyi...lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 40-199 4.3e-34 112.7 In-house 32-189 (297) alignment 
Range on Protein: 40-199
Range on HMM: 32-189/297.0
HTKRKNRYKDIIPYDFNRVVLTTQrsededISGSDYINASSVEH--GESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNL
 . |||||.||. .| .|| |         |...|||||  |     |.. ..| .||||  |.||||....|.|||..|| ... |. | ||| |||. 
sslrknryrdilatddtrvkllrv......iterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

H-EFDVFDEFEVDNMAEDAID--QDFLvRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRL
  |     .. |. ... . .  . .|   |.. ..  || .    . .|||||||.    . |.
vqerlkagdvvveflsstsdefdrvil.telqliyrsesrvvrhvqflswpdhGvpsdledlvrf
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 40-285 2.7e-28 93.4 In-house 51-287 (310) alignment 
Range on Protein: 40-285
Range on HMM: 51-287/310.0
HTKRKNRYKDIIPYDFNRVVLTTQRSEDEdisgsDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHE
.   |||| |..  |  || |. ..|  |     ||| |  |     .  || ||||| ||. |||||....    ... |.. |. | ||  ||| |  
kymhknrysdvvcldtsrvklkidksrye.....dyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgv

FDVFDEFEVDNMAEDAidQDFLVRTLKVT---------HKGASR---IIYQYHYHAWPDHGVPARPGSV--MRLIAAFRErqpsdqaAPLVIHCSAGVGR
 . .    | |..| .  ..| .  | ||          . |      .   ..  ||| |||         ||.|  |         | |.|||||..|
tetygcirvtnlsess..eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh.......gpcvvhcsagkdr

TGhfllgTICAIDIVWSMLKQmGLDapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAIL
..     ...|... .  |.. ||     |. .|.  |...|   .||| ||... .  .
ly.....vvvalklkidkldr.glk...vdaeevktellksraiciqtelqyliidrvri
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 40-138 2.1e-27 90.8 In-house 46-154 (350) alignment 
Range on Protein: 40-138
Range on HMM: 46-154/350.0
HTKRKNRYKDIIPYDFNRVVLT----TQRSEDEDISGSDYINASSVEHG------ESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFK
..  |||||.|.||. .|| |     .  . .  .|..|||||. ..        ... ..|| |.||| |.|||.... . .|.....  . .|... |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CAKYWPNLH
| .||... 
cyrYWqegs
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 40-137 3e-17 57.0 In-house 47-156 (349) alignment 
Range on Protein: 40-137
Range on HMM: 47-156/349.0
HTKRKNRYKDIIPYDFNRVVLTTQR----------SEDEDISGSDYINASSV--EHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDR
..  |||||||.||.  ||.|              || .     |||||  .   . . . ..|| | ||| |.|||....  . |..|.   . .|.. 
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl

FKCAKYWPNL
 || .|| .|
ekcdiywqel
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 41-286 2.8e-47 155.9 In-house 7-238 (239) alignment 
Range on Protein: 41-286
Range on HMM: 7-238/239.0
TKRKNRYKDIIPYDFNRVVLTtQRSEDEDisgSDYINASSVEH-GESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHe
 | |||| .|. ||..||||  . |.|     ||||||| .     |   .||.|| .  .  |||||.|..   ..||   . |  . || .|||.   
nkaknryanivtydhsrvvle.klsndph...sdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.

fDVFDEFEVDnMAEDAIDQDFLVRTLKVTHKGA--SRIIYQYHYHAWPDHGVPARPGSVMRLIAAFReRQPSDQAAPLVIHCSAGVGRTGHFLLgticaI
   . .. |  . .  .  |...||. ... |    | .||||.  |||.|||    .|. |      ..    | | |||||||||||| ||.     |
.skycnlrvt.lrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit.kdslpgarpwvihcsagvgrtgaflv.....i

DivwSMLKQMGLdAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
|   .||.|        |||. |  .|. || |||| .||||.. |.|.
d...amlrqakk.qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 41-285 3.3e-47 155.7 In-house 8-238 (239) alignment 
Range on Protein: 41-285
Range on HMM: 8-238/239.0
TKRKNRYKDIIPYDFNRVVLTtQRSEDEDisgSDYINASSVEH-GESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHe
 | |||| .|. ||..||||  . |.|     ||||||| .     |   .||.|| .  .  |||||.|..   ..||   . |  . || .|||.   
nkaknryanivtydhsrvvle.klsndph...sdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.

fDVFDEFEVDnMAEDAIDQDFLVRTLKVTHKGA--SRIIYQYHYHAWPDHGVPARPGSVMRLIAAFReRQPSDQAAPLVIHCSAGVGRTGHFLLgticaI
   . .. |  . .  .  |...||. ... |    | .||||.  |||.|||    .|. |      ..    | | |||||||||||| ||.     |
.skycnlrvt.lrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit.kdslpgarpwvihcsagvgrtgaflv.....i

DivwSMLKQMGLdAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAIL
|   .||.|        |||. |  .|. || |||| .||||.. |.|
d...amlrqakk.qktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 41-287 7.5e-44 145.0 In-house 41-276 (307) alignment 
Range on Protein: 41-287
Range on HMM: 41-276/307.0
TKRKNRYKDIIPYDFNRVVLTTqrsedeDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHE-
   ||||.|.   | .|.|...      |   |||| |  .       .||..||||  |  .|| |  ...|  |.| |.. |  . || .|||  .  
ntdknryqdvkcqdkgrivvkf......dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegq

FDVFDE----FEVDNMAEDA--IDQDFL-VRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQpsdqaAPLVIHCSAGVGRTGhfllg
  || |      |.|.  .    |.|.. | ||||   . || | .. .. |||.|||    . . |. | |  .      |.|.||||||||.|     
klvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt.....npvvvhcsaGvGrsG.....

TICAIDIVWSmlkQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
|| || .|     .|     | |. ..|  ||..|.  .||| ||..... .|. 
tivaislvqd...kmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 41-287 1.6e-20 67.9 In-house 47-278 (303) alignment 
Range on Protein: 41-287
Range on HMM: 47-278/303.0
TKRKNRYKDIIPYDFNRVVLTtqrseDedisgSDYINASSVEHgESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEF
   |||. |.|  |  .| |.     |     | || || .|  .|. . | .| ||.||  |||.|. |. |. |..     | |..     .|.  .|
nmdknrfvdvicldhskvkls.....d.....ssyihasylel.dsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf

DVFDEF--EVDNMAEDAIDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPAR--PGSVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTGHFLLGTICA
  |.|    | .. .  . . . .. | |.      ... .||.|||   .|.   |  | ..       .   .. | |    .|.||.| | |   . 
lkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetah

IDIvwsmlKQmglDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
. .     ..   . ...|. ...  .|. |   ||   |. .||  . . 
lsl.....hs...eqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 41-145 2.3e-12 41.0 In-house 96-189 (244) alignment 
Range on Protein: 41-145
Range on HMM: 96-189/244.0
TKRKNRYKDIIPYDFNRVVLTTQRsedediSGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDrfkcaKYWPNLHEF
   |||    .|.||||| |.          |  ||||| |      . .| .| ||  |  |||.|. |. | ..|.   . |.|     .|||.   .
nswknregaglpfdfnrvplskgs......mgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpdsepl

DVFDE
. ..|
ewyee
Y_phosphatase Protein-tyrosine phosphatase 42-285 3.1e-77 254.5 Pfam-A 2-234 (235) alignment 
Range on Protein: 42-285
Range on HMM: 2-234/235.0
KRKNRYKDIIPYDFNRVVLttqrseDEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWP-NLHEF
|.|||||||.|||..|| |      ... . ||||||. |.  ... .|||.||||..|..|||||.|...|...|| ..  |..| |||.||| . .|.
kkknRykdilpydktrvkl......kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

DVFDEFEVDNM-AEDAIDQDFLVRTLKVTHKGASR---IIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQpSDQAAPLVIHCSAGVGRTGhfllgTICA
  .....| ..  | ...... .|.|....|....   ...|.||..|||||||. | |...|| ...... ... .|.|.||||||||||     |..|
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtg.....tfva

IDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAIL
.||....|.. .     .|..|.|  ||..|| |||...||.|.|||||
ldilleqleaeee....vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 42-285 3.1e-77 254.5 In-house 2-234 (235) alignment 
Range on Protein: 42-285
Range on HMM: 2-234/235.0
KRKNRYKDIIPYDFNRVVLttqrseDEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWP-NLHEF
|.|||||||.|||..|| |      ... . ||||||. |.  ... .|||.||||..|..|||||.|...|...|| ..  |..| |||.||| . .|.
kkknRykdilpydktrvkl......kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

DVFDEFEVDNM-AEDAIDQDFLVRTLKVTHKGASR---IIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQpSDQAAPLVIHCSAGVGRTGhfllgTICA
  .....| ..  | ...... .|.|....|....   ...|.||..|||||||. | |...|| ...... ... .|.|.||||||||||     |..|
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtg.....tfva

IDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAIL
.||....|.. .     .|..|.|  ||..|| |||...||.|.|||||
ldilleqleaeee....vdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 42-287 3.8e-65 214.9 In-house 44-275 (515) alignment 
Range on Protein: 42-287
Range on HMM: 44-275/515.0
KRKNRYKDIIPYDFNRVVLTTQrsedEDISGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLH-EF
 .|||||.|.||| .|| |       .|   |||.||| ..  ...  .||||||.. ..|||||......|  ..|  .  |.|. ||.||||.   . 
fkknryknilPydsvrvklevi....ndnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgds

DVFDEFEVDNMAEDAiDQDFLVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPsDQAAPLVIHCSAGVGRTGhfllgTICAIDIV
  | ...|. .. .| . . . |.|.|..   || . |.|.. |||.||| .  |...|| . .  .    . ||.|||||||||||      ...|| |
vkfGsikvelvslea.ctggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhg.qythpliihcsaGvGrtG.....vvisidsv

WSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
 .  |.    .   |.|..|  .||.|| .|||..|| |.| |.|. 
vahakt....trmvdvfnfvtnirqkrpylvqtqeqyafiygavled
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 42-288 7.6e-42 137.9 In-house 57-283 (290) alignment 
Range on Protein: 42-288
Range on HMM: 57-283/290.0
KRKNRYKDIIPYDFNRVVLttqrsedEDISGSDYINASSVEHgeSQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLH-EF
 .||||||..  |  ||.|       .|    ||. |  |.    .  || .||.|  |  |.|||. ...|  .|| |...|. . ||..|.|. . | 
fkknrykdvvcndktrvil.......kdGydGdyvhanyvkG..lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

DVFDEFEVDNMAEDAIDQDFLVRTLKVTH--KGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRErqpsdQAAPLVIHCSAGVGRTGHFllgtiCAID
  | |. |    ||  |..   .|| | .  .| . ... ..  .|||. |.    ...|.. . |.      . |.|.|||||.|||| |      ||.
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk.....asGpvvvhcsaGiGrtGtf.....vaie

IVWsmlkQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
.      |. ||   .|. ..|  ||. | . || . ||. . ...||| 
vgl....qilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlG
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 42-280 3.5e-29 96.5 In-house 51-273 (301) alignment 
Range on Protein: 42-280
Range on HMM: 51-273/301.0
KRKNRYKDIiPYDFNRVVLTTQRSEDEDISgSDYINASsvehGESQcRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFD
| |.||. . | . .  |   .  .   |  ...|..|    |... ||||.||||. | .||| ||   ||  .|| ..  |.   ||..| |   . .
kdkhryptv.PckPstavevivdGkrvPih.anwipts....Ghph.rfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisek

V-FDEFEVDNMAEDAIDQD-FLVRTLKV---THKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRErqpSDqaAPLVIHCSAGVGRTGHFLlGTICa
.  . |..    .. | ..    |||.|   | | |.| .  | |. |.|.|||     .. |.   ..   |.   |.|.|||||.||.  |. || . 
ldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk...se..kPivvhcsaGiGrsvafi.gtey.

idivwsmLKQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFV
       | .  .  |  .. . .  ||.||   |||. |  ..
.......lareveadptieltealkhlrehrwngvqtnsqlywm
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 42-124 1.9e-13 44.6 In-house 38-118 (347) alignment 
Range on Protein: 42-124
Range on HMM: 38-118/347.0
KRKNRYKDIIPYDFNRVVLTTQRSEDEDISGS-DYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVmacNIFE
  ||| ||    |  ||||. ..|.      .  ||||| .   ...  .| .| |||.|. |||.|.    |  ||    |||
lsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv...tife
0041856 (Phosphotyrosine protein) phosphatases II 43-288 9.7e-48 157.5 In-house 3-171 (182) alignment 
Range on Protein: 43-288
Range on HMM: 3-171/182.0
RKNRYKDIIPYDFNRvvlttqrsededisGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACnifendrfkCAKYWPnlhefdv
 ||||.||.|||..|              ..|||||. .  .  ..|||| ||||..|. ||.|||.| .....|...         .  |||       
dknrysdilpydhsr..............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.......

fdefevdnmaedaidqdflvrtlkvthKGASRIIYQYHYHAWPDHGVPArPGSVMRLIAAFRErqpsdQAAPLVIHCSAGVGRTGhfllgTICAIDIVWS
                           .   | ..||.|. |||||||  . .. ..| . .|     .  | ..||||||||||     |..|......
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtg.....tlvaaylmkk

MlkqmgldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
.          ......| ..|..|| ||.|..||.|.. |.|.|.
l.........gvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 44-286 9e-30 98.6 In-house 38-268 (285) alignment 
Range on Protein: 44-286
Range on HMM: 38-268/285.0
KNRYKDIIPYDFNRVVLTTQrseDedisgSDYINASSVE-HGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPN-LHEFD
 ||| |.   .  ||||  .   |      ||| || .   |. |  .|..||||| || |||.|.... .  |.| | .||    ||| |.|. | |  
lnryadvrcieetrvvlknh...d.....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

VFDEFEVD--NMAEDAIDQDFLV-RTLKVTHKGASRIIYQYHYH--AWPDHGVPARPGSVMRLIAAFRERQPSDqaAPLVIHCSAGVGRTGHFLlgticA
 | ..|.   .  |.||    |   |.  |   .|  .|  | .   |||.  |     .. |    .. .| .   |...|||||||||  |.      
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke..kpicvhcsagvgrtatfv.....g

IDivWSMLKQMglDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
||  .. .. |  . |  .....|  .|  |   ||.  |..|.|  ...
id..yatirim..enpniemldivremramrfqavqshmqflflyvvlme
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 44-289 2.2e-19 64.0 In-house 54-286 (302) alignment 
Range on Protein: 44-289
Range on HMM: 54-286/302.0
KNRYKDIIPYDFNRVVLTTQRseDedisgsDYINASSVEHGESQCRFIASQGPLPHTL---DDFWRMLWEKDVRIVVMACNIFENDRfKCAKYWP-NLHE
||. .|.  .| |.| |...   |      .|.|||.||  | .   | .| |   .    ..|||| ... .  ||..    | ..    ...| .  .
knqsedvpildsnlvkleaep..d......syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

FDVFDEFEVDNMAEDAIDQDFLVRTLKVTHKGASR--IIYQYHYHAWPDHGVPARPGSVMRLIAAFrERQPSDQAAPLVIHCSAGVGRTGHFLLGTIcAI
.  .... | |   .  ...    .. |  .| |   ..  |. . |... || . ..... .|     . ..  ...||    |.|| | ||  .. |.
ykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlav.av

DIVwsmlKQMglDAPCfdIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
. .    ..   ..|.  | ..|  .|. ||..|.. .|||..| |.| ...
ekl....qkg..kepn..ikeivksiRsqRpravdslkQyvslyialllyik
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 44-199 3.5e-07 23.3 In-house 30-164 (169) alignment 
Range on Protein: 44-199
Range on HMM: 30-164/169.0
KNRYKDIIPYDFNRVVLttQRSEdEDIsGSDYINAssvehgesqcrfiasqgplphtlddfwRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVF
|||    .   . || |  ||   ||. |||||||                           ||.|| .  ..|.  .  . . |   |   .||   ..
knrpagplapshtrvkl..qrvm.edl.gsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyqlhpavil

DEFEVDNMA--EDAIDQD-----FLVRTLKVTHKGASRII---YQYHYHAWPDHGVPARPGSVMRL
 |.  | .    | ...       |.    | |.  . .      .|| .||. |||  |  | .|
gewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvhvghl
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 44-199 6.4e-07 22.3 In-house 29-163 (169) alignment 
Range on Protein: 44-199
Range on HMM: 29-163/169.0
KNRYKDIIPYDFNRVVLttQRSEdEDIsGSDYINAssvehgesqcrfiasqgplphtlddfwRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVF
|||    .   . || |  ||   ||. |||||||                           ||.|| .  ..|.  .  . . |   |   .||   ..
knrpagplapshtrvkl..qrvm.edl.gsdyina...........................rmiwetnasvivvlGdtddknnfwpekedyqlhpavil

DEFEVDNM--AEDAID-----QDFLVRTLKVTHKGASRIIY---QYHYHAWPDHGVPARPGSVMRL
 |.  | .    | ..      . |.    | |.  . .      .|| .||. |||  |  | .|
Gewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhvghl
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 51-145 1.3e-09 32.5 In-house 3-80 (130) alignment 
Range on Protein: 51-145
Range on HMM: 3-80/130.0
IPYDFNRVVlttqrsededisGSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDrfkcaKYWPNLHEFDVFDE
......|.             | .||||| |   .    .. .| ||  |  |||.|. |. | ..|.   . |.|     .|||.   .. ..|
lefevsrlq............gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePlewyee
0044763 (Phosphotyrosine protein) phosphatases II 52-285 1.5e-32 108.0 In-house 1-168 (178) alignment 
Range on Protein: 52-285
Range on HMM: 1-168/178.0
PYDFNRVVLTTQrsedEDISGSDYINASSVEHGesqcRFIASQGPlphtlDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEfdvfdefevdnm
|.|..||.|..     |.. .||||||| . .|     ...|..|      |....|.| ... .|. .. .|. ..|| .|||  ..            
pldrtrvllsnl....eglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag............

aedaidqdflvrtlkvthkgasriiYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPsDQAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMlkqmglda
                         .||..  .||||||  .  ....... .| .. ..  | ..||||||||.| .      |.......        
.........................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlv.....aaylmkkl........

pCFDIFQVVWFLRQHRPaMVQTEDQYVFVYKAIL
  ....... ..|..|| .|....|. ..|.  |
.glsleeaielvrerRp.ivpnpgqlrqLyefel
0051429 (Phosphotyrosine protein) phosphatases II 70-290 1.4e-44 148.1 In-house 1-227 (272) alignment 
Range on Protein: 70-290
Range on HMM: 1-227/272.0
ISGSDYINASSVEHGesqC------RFIASQGPLPHTLDDFWRMlWEKDVRIVVMACNIFENDRFKCAKYWP--NLHEFDVFDEFEVDN--------MAE
.. |.||||. |      .      |...|.||||.| .||||. .| ... .|. .. .| .|.|| .|||  ... ....|. . .         . .
lplsgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtlls

DAIDQDFLVRTLKVT---HKGASRIIYQYHYHAWPDHGVPARPgsVMRLIAAFRErqpsdqAAPLVIHCSAGVGRTGhfllgTICAIDIVWsmlKQMGLD
  .  |...|.| .|   . |..| ....||..|||||||  .  . .|......        |...|||||..|||     |..|....     ...|.
eellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTG.....tvvalllll...lgvsle

APCFD-------IFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
. . |       ....|  ||..||..||||.||.|.|.|.|.|.  
tivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrs
0046846 (Phosphotyrosine protein) phosphatases II 71-288 2.8e-42 139.7 In-house 10-173 (176) alignment 
Range on Protein: 71-288
Range on HMM: 10-173/176.0
SGSDYINASSVEHGesqcRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVfdefevdnmaedaidqdflvrtlkvthk
 ..|||||. .  .    |.|| |||||.|| ||..||.| ....||. .. .| .|.||. ||| |.....                            
ldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

gasriiyQYHYHAWPDHGVPARpGSVMRLIAAFRERQPSDqaAPLVIHCSAGVGRTghfllGTICAIDIVWSmlkqmgldAPCFDIFQVVWFLRQHRP-A
       ||... |||||||     ...|... ||.. ..   | ..|||||.|||     ||..|......          ........ ..|..||  
.......qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRt.....gtlvaayllel........ekglsveealalvreqRplg

MVQTEDQYVFVYKAILDLV
.|||..|| |.|...| | 
avqtpeQyrflyefellll
0036282 (Phosphotyrosine protein) phosphatases II 72-282 4.5e-43 142.3 In-house 1-164 (174) alignment 
Range on Protein: 72-282
Range on HMM: 1-164/174.0
GSDYINASSVEHGESQCRFIASQGPLPhtlddFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNlhefdvfdefevdnmaedaidqdflvrtlkvTHKG
|||||||| .   .   |.||.||||.     ||.||.| ....||| .. .|....||  |||                                ... 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

ASRIIYQYHYHAWPDHGVPARPGsVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTghfllGTICAIDIVWSMLKqmgldAPCFDIFQVVWFLRQHRPAMV
 .| ..||.|  |||||||  .  . ... . .| . .|.  |...|||||||||     ||..|....  .|.      .  |....|  ||..|| ||
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRt.....Gtlvaaylmlrgll.....eslvdaldlvrelRlqrpgmv

QTEDQYVFVYK
||..|| |.|.
qtpsQyrflyy
0043147 (Phosphotyrosine protein) phosphatases II 72-281 7.7e-42 138.3 In-house 4-154 (172) alignment 
Range on Protein: 72-281
Range on HMM: 4-154/172.0
GSDYINASSVEHGESQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIfendrfkcakywpnlhefdvfdefevdnmaedaidqdflvrtlKVTHKG
|||||||| ..     .|||| ||||..||.||||||.|......|....                                             .. ..
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpel

ASRIIYQYHYHAWPDHGVPaRPGSVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTGhfllgTICAIDIVWsmlKQMgldapcfDIFQVVWFLRQHRPAMV
 .| ..||.|. |||||||  .  .....   .|..  ..  | ..||||||||||     |..|.....   ...       .....| ..|..|| .|
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtg.....tlvaaylml...lgl.......sleeavalvrekRpgav

QTEDQYVFVY
|...|| |.|
qnpsqyrfly
0051082 (Phosphotyrosine protein) phosphatases II 73-284 4.2e-33 109.4 In-house 3-149 (151) alignment 
Range on Protein: 73-284
Range on HMM: 3-149/151.0
SDYINASSVEHGesqcrFIASQGPLPhtldDFWRMLWEKDVRIVVMACNIFENDrfKCAKYWPNLHefdvfdefevdnmaedaidqdflvrtlkvthkga
|||||.| |. |     ...|.|||.    ||...|.| ... .|. .. .|..  .|..|.|.|                                   
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

sRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRErqpsDQAAPLVIHCSAGVGRTGHFLLGTICAIDivwsmlkqmgldapcFDIFQVVWFLRQHRPAMVQ
 . ....... |||.|.|  . .|.... ....    ..  |...|||||.|||| . .  ... .               ....... ..|..|| .||
.ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg...............vsleealeeyrlkrpgvvq

TEDQYVFVYKAI
...|..|...|.
pnqqflfqlfal
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 73-296 1.1e-19 65.7 In-house 46-267 (290) alignment 
Range on Protein: 73-296
Range on HMM: 46-267/290.0
SDYINASSVEHGESQcRFIASQGPLPHT-------LDDFWRMLWEKDVRIVVMACNIFENDRF----KCAKYWPNLHEFD-VFDEFEVDNmAEDAIDQDF
.||| |. |   . . |.|..| |. ..       . .|| |  .  |. ||| |.  |...      |||| |.  . .  |. ..|    .   ..|.
ddyiHAnrvtcpngl.rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC.kskekeddv

LVRTLKVTHKGASRI-IYQYHYHAWPDHGVPARPGSVMRLIAAFRerqpsDQAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGLDapcFDIFQV
 .|.| |.. .     .  . .. | .  |.  . ... ||   .      . .| ..||  |. |       .. ||.. . .. ..  .   . . .|
etRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk.....asktpvivHcvdGiSrsA.....alaaiilgyQkiaetsgs...vkledv

VWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVLASMD
.  ||..|  ..... .. ||  .|. |...|| .. 
lkalrkqralaitsalelafvdagivllaievldqfa
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 86-282 9.3e-18 59.1 In-house 3-198 (199) alignment 
Range on Protein: 86-282
Range on HMM: 3-198/199.0
SQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEF-DVFDEFEVDNMAEdAIDQDF----LVRTLKVTHKGASRIIYQYH
.| |.||.| || .|. |||.|.||     .||  .   |     . |||  .     .  . |   .  .   |.    |. | ..|   ..| | .| 
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttkti.ttkpdytitaliltnnttappstreishyq

YHAWPDHGVPARPGSVMrLIAAFRE---RQPSDQAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQmgLDAPCFDIFQVVWFLRQHRPAMVQTEDQY
. .| ..  |     |  .. | ||   .   .. ||...||| | | || |.     |.||     ..    .   |.|.|   ||| |  .. . ..|
ftswkekttpnvalfvg.fvvasrevskkyeqekdapvivhcsdgqgftgvfv.....aldigvrshee..sktsvvdlfevakrlrqarcgiisslqhy

VFVYK
 |.|.
nfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 86-282 1.1e-17 58.9 In-house 2-197 (198) alignment 
Range on Protein: 86-282
Range on HMM: 2-197/198.0
SQCRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEF-DVFDEFEVDNMAEdAIDQDF----LVRTLKVTHKGASRIIYQYH
.| |.||.| || .|| |||.|.||     .||  .   |     . |||  .     .  . |   .  .   |.    |. | ..|   ..| | .| 
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttkti.ttkpdytitaliltnnttappstreishyq

YHAWPDHGVPARPGSVMrLIAAFRE---RQPSDQAAPLVIHCSAGVGRTGHFLlgticAIDIVWSMLKQmgLDAPCFDIFQVVWFLRQHRPAMVQTEDQY
. .| ..  |     |  .. | ||   .   .. ||...||| | | || |.     |.||     ..    .   |.|.|   ||| |  .. . ..|
ftswkekttpnvalfvg.fvvasrevskkyeqekdapvivhcsdgqgftgvfv.....aldigvrshee..sktsvvdlfevakrlrqarcgiisslqhy

VFVYK
 |.|.
nfiyq
0049260 (Phosphotyrosine protein) phosphatases II 88-282 2.6e-38 126.4 In-house 9-144 (152) alignment 
Range on Protein: 88-282
Range on HMM: 9-144/152.0
CRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWpnlhefdvfdefevdnmaedaidqdflvrtlkvthkgasriiyQYHYHAWPDH
 .||| |||.|.||.||||||.| .....|| .. .|....||..|.                                           ||... ||||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qylhlpwpDh

GVPARPGSVMRLIAAFRERqPSDQAAPLVIHCSAGVGRTGhfllgTICAIDIVWsmlkqmgldaPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYK
|||  .  .. |. . ...   |.  | ..||||||||||     |..|.....            ......| ..|..|| .|....|. |.|.
gvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtg.....tlvaaylml..........lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 88-170 4.4e-07 23.6 In-house 236-314 (440) alignment 
Range on Protein: 88-170
Range on HMM: 236-314/440.0
CRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIfeNDRfKCAKYWPNLHEFDVFDEFEVDNMAEDAIDQdFLVRTLKVTHK
  |||.| ||  |. ||||.. .  .  ..|  ..  ||.  |. |||       |  | |     . ...   ||||.. .|
nafiatqmpldstvldfwrlvhdyristiimlnql..ndk.tcsiywpvntrsvtfgpftvghkgsenmnr.vkvrtlelkyk
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 96-282 2.6e-17 57.2 In-house 99-282 (302) alignment 
Range on Protein: 96-282
Range on HMM: 99-282/302.0
PLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPN-LHEFDVFDEFEVD------NMAEDAIDQDFLVRTLKVTHKG----ASRIIYQYHYHAW
|   ||. .| .. . .| |||  |.. |..  |||.|. . . .   | .. |       ...| .  ..| . |.... .       . .   .. ||
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHGVPARPGSVMRLIaAFRERQpsdqAAPLVIHCSAGVGRTGhfllgTICAIDIVWsmlkQMGLDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYK
|||| |. . . . ..  | |         ...||||||||||     |. ||        |. .     |. ..|  .|| |   ||.|.| ...  
pdhGapkeaytaldil.kfcesy....kknvlvhcsaGvGrtG.....tlvaikyGi....qlcskkkvtdllsivlpvrqcryGavqdeqqliylll
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 97-289 2.4e-19 64.4 In-house 39-222 (255) alignment 
Range on Protein: 97-289
Range on HMM: 39-222/255.0
LphTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNlhEFDVFDEFEVDNMAEDAIDQDFLVRTLKVTH----KGASRIIYQYHYHAWPDHGVPAR
|  |.| |....  ..   ||| |.  |... || .|.|   | |    ..  |..     .| ..|||..|     |   . .  |.|. |...  |  
l..tvdkfyqtivqtktevvvmlcdfaeegvekcssyfpl..ekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPel

PGSVMRLIAAFRErqpSdqaAPLVIHCSAGVGRTGHFLlgticAIDIVWS-MLKQMGL-DAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
.  .. .. . |.   |    ..|.|||.|.||.  |       ...|.  |....   ..  .|  ...  ||..|.. ..|  |  |    .|||| 
areilnilkvvrd...s...ksvvvhCstGiGrsaafv.....laelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvf
subfamily_hpo-7_pd Subfamily hpo-7 97-296 8.6e-18 59.2 In-house 43-235 (263) alignment 
Range on Protein: 97-296
Range on HMM: 43-235/263.0
LPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNlhEFDVFDEFEVDNMAEDAIDQDFLVRTLKVTH----KGASRIIYQYHYHAWPDHGVPAR
|  |.| |....  .    ||| |.  |... || .|.|   | |    ..  |..   . .| |..||...     |   . . .| |  |...  |  
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPl..ekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpel

PGSVMRLIAAFRERQpsdqaaPLVIHCSAGVGRTGHFLLgticaIDIVWS-MLKQMGL-DAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQ
. ...... . |. .      .||.|||.|.||.  | .     ...|.  |....   ..  .|  ...  ||..|.. ..|  |  |    .||.| .
areilnilkvarnsk......slvvhcstGiGrsaafsv.....aElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvln

VLASMD
  |  .
nfakge
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 101-289 1.4e-07 24.5 In-house 131-310 (346) alignment 
Range on Protein: 101-289
Range on HMM: 131-310/346.0
LDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPNLHEFDVFDEFEVDNMAEDaIDQDFLVRTLKVTHKGAS-RIIYQYHYHA-WPDHGVPARPGSVMR
..||| |........| .            . .  .   ..    . ..|   | .  |    |..|  .| |  .| | |.|| |     | .   ...
vedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrrad.vsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlpiik

LIAAFRERQPSdQAAPLVIHCSAGVGRTGHFlLGTICAIDIVwsmlkQMGLDApcfDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQ
.|  |   .   |.| . .    | ||.  | .|.. ||. .     . |..    .|....  ..| ||  |..  ||  .|  ..| . 
mihqflsekqv.qnagvcvvslfgcgracsf.igalyainql.....nngiep...niceimknikqqrpggvesfaqyasiyaivfdyia
0048179 (Phosphotyrosine protein) phosphatases II 154-282 1.8e-21 71.8 In-house 48-139 (144) alignment 
Range on Protein: 154-282
Range on HMM: 48-139/144.0
DaidqdflvrtlkvthkgasriIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDqaAPLVIHCSAGVGRTghfllGTICAIDIVWsmlkqmgldAPC
                      ..||..  |||||||  .  . .......| ....   | ..|||||||||     ||..|.....            
e.....................giqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRt.....gtlvaaylmk.........klg

FDIFQVVWFLRQHRPAMVQTEDQYVFVYK
....... ..|..|| .|....|. |...
lsleealalvrsrrpgavpnpgqlrfLle
0038934 (Phosphotyrosine protein) phosphatases II 160-283 6.9e-09 31.1 In-house 45-172 (194) alignment 
Range on Protein: 160-283
Range on HMM: 45-172/194.0
FLVRTLKVTHKGASRII------------------YQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTGHFllgticaidIVW
.||| ||  ...   .|                  ..|.   .||.|..     ..| . .  |    |.    ..|| ||.|||| .         .. 
dlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtl.........vaa

SMLKQMgldapCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKA
 ... .     ...  . . ..|. || .... |..  ..| 
YLiyrl.....gmsaeeAialfrekRpgaipnqdyleallkr
0048076 (Phosphotyrosine protein) phosphatases II 161-286 2.7e-23 77.7 In-house 32-141 (145) alignment 
Range on Protein: 161-286
Range on HMM: 32-141/145.0
LVRTLKVTHKGASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDqaAPLVIHCSAGVGRTGHFLlgticAIDIVWSmlkqmgldaPCFDIFQVV
.| .|  . .. .| ..||.|  |||||||  .  ....... .| ....   | ..|||||||||| .      |......           .......
tvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlv.....aaylmll.........lgvsleeal

WFLRQHRPAMVQTEDQYVFVYKAILD
 ..|..|| .|....|. |.|...| 
elvrsqrpgavpnpgqlrflyefele
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 172-287 1.5e-18 61.6 In-house 213-343 (350) alignment 
Range on Protein: 172-287
Range on HMM: 213-343/350.0
ASRIIYQYHYHAWPDHGVPARPGSVMRLIA---------AFRERQPSDQAAPLVIHCSAGVGRTGHFL-----LGTICAIDIVWSMLKQMGLDAPCFD-I
   ..|| ... |.| ..  .| |... .            ..   .....|...|||||||||| ..     |  .  .. .    ...   |  .| |
dPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDli

FQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
...|  ||. |  |||. ||..|.|.|.| .
siivnelrkqrismvqnldqfifiYeallfy
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 172-287 1.8e-12 41.2 In-house 216-343 (349) alignment 
Range on Protein: 172-287
Range on HMM: 216-343/349.0
ASRIIYQYHYHAWPDHGVPARPGSVMRLIAA---------FRERQPSDQAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLK-------QMGLDAPCFD
   ...|  .  |.| ..   | |... .            |    .|| ..|..||||| ||||     ... .|.. |.|.       .. | |  .|
kPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtG.....vlvtldlllsileplqnesnkiklqallkD

-IFQVVWFLRQHRPAMVQTEDQYVFVYKAILDL
 |. .|  ||. | .|||   |....|.|.|  
lisiivnelrkqrismvqnlaqfiaiyealLky
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 173-287 5.3e-22 72.7 In-house 88-193 (440) alignment 
Range on Protein: 173-287
Range on HMM: 88-193/440.0
SRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQmgldAPCFDIFQVVWFLRQHRPAMVQ
|| . ||||..|||.|||   | |...|    | |     .||..|||||.||||      | |.| .    |.    .   ||| ..  .|. || |||
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtg.....viiavdsilreakr....sdqidifsfinsmrnnrpqmvq

TEDQYVFVYKAILDL
| .||.||..|.|. 
tpeqyafvheavleg
PTPc_DSPc_SM00012 176-285 5.9e-32 105.4 In-house 2-104 (105) alignment 
Range on Protein: 176-285
Range on HMM: 2-104/105.0
IYQYHYHAWPDHGVPARPGSVMRLIAAFRERQPSDQ-AAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQMGldaPCFDIFQVVWFLRQHRPAMVQTE
...|||..||||||| .. |...|..|... .   . ..|.|.||||||||||     |..|.||....|..      ..||||.|. ||..|| |||||
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtg.....tfvaldillqqleket...kevdifqivkelrkqRpgmvqte

DQYVFVYKAIL
.||.|.|.|.|
eqylflyrall
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 201-288 1.5e-10 35.4 In-house 219-295 (297) alignment 
Range on Protein: 201-288
Range on HMM: 219-295/297.0
AAFRERQPsdQAAPLVIHCSAGVGRTGHFLLGticaiDIVWSMLKQMGLdaPcfDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLV
 ..|  .|  . |.|..||||||||.|  .|      |.. ..|..  .  |  |.  .. .||. |. .||| .|. ..|.|.|  .
eslraemp..rnayllvhcsaGvGrsGvvvls.....dvilaklrkkri..p..dvaailsilreqrarlvqtleqfellydavlkkl
subfamily_CG42327_pd Subfamily CG42327 210-286 4.8e-14 46.7 In-house 245-313 (319) alignment 
Range on Protein: 210-286
Range on HMM: 245-313/319.0
DQAAPLVIHCSAGVGRTGhfllgTICAIDIVWSMLKQmglDAPCFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
..  |||.||| ||||||     .. | ||    |..        || |.| ..|. |   |.| .|| |.|| .  
esqGPlvvhcsdGvGrtG.....lviasdiairslee...skrsvdiPqlvssvrrdrasavltkeqyefiykvlse
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 215-286 7.1e-11 36.3 In-house 1-63 (69) alignment 
Range on Protein: 215-286
Range on HMM: 1-63/69.0
LVIHCSAGVGRTGHFLlgticAIDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
.|.|||.| |||| |.     || .  . .|   |     |||  | ..|. || ||  | .|.|.. |. .
mvvhcssgtgrtgtfi.....aimvemariksekl....vdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 216-286 2.5e-10 34.6 In-house 1-62 (69) alignment 
Range on Protein: 216-286
Range on HMM: 1-62/69.0
VIHCSAGVGRTGHFLlgticAIDIVWSMLKQMGLdapcFDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILD
|.|||.| |||| |.     || .  . .|   |     |||  | ..|. || ||  |..|.|.. |. .
vvhcssGtGrtGtfi.....aimvemariksekl....vdifnnvqymrkcrpmmvmneneymfihdalve
subfamily_ptpA1_pd Subfamily ptpA1 254-292 1.7e-07 25.3 In-house 364-402 (418) alignment 
Range on Protein: 254-292
Range on HMM: 364-402/418.0
FDIFQVVWFLRQHRPAMVQTEDQYVFVYKAILDLVQQVL
|..| .|  ||..|| |||  .||.|.||.||| . . |
fnlfsivlklreqrpgmvqqleqylfcyktildeiyhrl