Gene PTPN13 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN13
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP065_AA protein Get Run
MbreP065_AA_2146-2430 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
FERM_N FERM N-terminal domain 148-241 1.9e-09 27.7 Pfam-A 1-80 (80) alignment 
Range on Protein: 148-241
Range on HMM: 1-80/80.0
VHLLNGEVLMRPVHVDTFVRDVFRHVVNEIGLHETAFFGLAL--MHTREVEFLDMERYVVSYFPTtpkrresknfyslsssEPTILDVQFRVEFYV
|.||.|.|.   |  .. ..... .|.. .|| || .||||   ..  |  .|| ....  ....                |.. . . .|| |||
VrlLDgtvkevtvddsktgavlletVckrlglteteyFgLafkedkknesnwLdhdktlreqgve................egkpttlllrvkfyv
FERM_M FERM central domain 250-358 2.6e-22 69.5 Pfam-A 8-126 (126) alignment 
Range on Protein: 250-358
Range on HMM: 8-126/126.0
AETRHLYYLQLKRDVIQGTLATTDQAAVQLSAFAMQAEYGDYD-PTTHVGRYFHVYD-------FFP--EQTVVNMTVAILEREMPGQHRKLKDMSPVRA
. ...|.|.|.|.|.... |  |.. |..| | ..|.|.||.. ....   ...  .       ..|  .. . ... . ||...  .|......|.. |
evrinllYeQakwdlleerldcteeeallLAALqlqiekgdseeeekasssdlekeeeeaeseqllpvsprllkkekskqleqrileahknvaglslaea

ETEYLKLAQKLHDYGVLYY
...||..||.|.|||| ..
klkylqaaqslpdyGvslF
FERM_C FERM C-terminal PH-like domain 368-452 5.1e-14 42.6 Pfam-A 4-87 (90) alignment 
Range on Protein: 368-452
Range on HMM: 4-87/90.0
RMPLLIGINSRGIIIYeDLNDRKQnPVKFAWSNIESLSLRNRKLTIMLKG-EGKQRHTVSADTQEKAAYLQHRCKAYHKFHFMMRQ
 . ||.|....|. || . |.. .   .| ||.|. || ...|.|| |.  . |. .. ........ .| . | ..|...  .|.
gtdllLGvdakGlliy.eknskls.nksFpWseirklsfkekkftiklrdekkkdvlkFyssqlrvnklllklcienhdlfrrrrk
PDZ PDZ domain (Also known as DHR or GLGF) 854-926 8.4e-18 54.5 Pfam-A 2-80 (81) alignment 
Range on Protein: 854-926
Range on HMM: 2-80/81.0
IRLEKRPNEGLGLSIRG-------GGVVSDLRPDSAAARDGrIKRKDRILAVNGKSLADLTHAEVIQLLRDTEDVVNLTI
..|||. ..|||.|. |       | .||.. |..||..|| .|  |.||.|||.......|.|..|..... ..| |||
vslekekrgglGfslkggsdkrdkgifvsevvpggaaeadg.lkeGDkIlsvNgvdvenvshdeavqaikgkkgevtLti
PDZ_2 PDZ domain 869-926 2e-06 17.2 Pfam-A 13-69 (82) alignment 
Range on Protein: 869-926
Range on HMM: 13-69/82.0
RGGGVVSDLRPDSAAARDGrIKRKDRILAVNGKSLADLTHAEVIQLLRDTEDVVNLTI
..| .| .  ..| ||. | .|  | ||.|.|| . .||. .   |  .  | |.||.
trgvlvvsVkessPaakag.lkpGDiilkvdgkkvksltdlkslllkkkpGdtvkltv
PDZ PDZ domain (Also known as DHR or GLGF) 987-1065 1.6e-14 44.0 Pfam-A 2-80 (81) alignment 
Range on Protein: 987-1065
Range on HMM: 2-80/81.0
VEIAKSTKTGLGFSITTKKKDPKSRILVGKVHAGTKADAAGLAVGDHIVAVDGRSLEGLTPTQALQVLSNTRSQVTLDI
|.. |..  |||||.   ... .  | | .| .|  |.|.|| .|| |..|.|...|...  .| |.. .....||| |
vslekekrgglGfslkggsdkrdkgifvsevvpggaaeadglkeGDkIlsvNgvdvenvshdeavqaikgkkgevtLti
PDZ_2 PDZ domain 1001-1058 2.9e-08 23.1 Pfam-A 5-60 (82) alignment 
Range on Protein: 1001-1058
Range on HMM: 5-60/82.0
ITTKKKDPKSRILVGKVHAGTKADAAGLAVGDHIVAVDGRSLEGLtpTQALQVLSNTR
............|| .|  .. |. |||..|| |..|||. .. |  |.  ..|....
vsvsqlentrgvlvvsVkessPaakaglkpGDiilkvdgkkvksl..tdlkslllkkk
PDZ PDZ domain (Also known as DHR or GLGF) 1233-1307 1e-15 47.8 Pfam-A 3-78 (81) alignment 
Range on Protein: 1233-1307
Range on HMM: 3-78/81.0
SLHR-GRLGLGVVVAGGVDLGLGGIFVQEVRAQTPAAKAGLQPSDRLLQIGDVDFSGMTHAEALEALKQASNPILL
||.. .| |||. ..|| | .  ||||.|| .  .|...||.. |..|....||.....|.|| .|.|...... |
slekekrgglGfslkggsdkrdkgifvsevvpggaaeadglkeGDkIlsvNgvdvenvshdeavqaikgkkgevtL
PDZ_2 PDZ domain 1253-1294 2.5e-07 20.1 Pfam-A 13-54 (82) alignment 
Range on Protein: 1253-1294
Range on HMM: 13-54/82.0
LGGIFVQEVRAQTPAAKAGLQPSDRLLQIGDVDFSGMTHAEA
 .|. |..|  ..|||||||.| | .|...... .  |. . 
trgvlvvsVkessPaakaglkpGDiilkvdgkkvksltdlks
PDZ PDZ domain (Also known as DHR or GLGF) 1366-1432 3.7e-11 33.2 Pfam-A 8-72 (81) alignment 
Range on Protein: 1366-1432
Range on HMM: 8-72/81.0
RSRGFGITIGGGADKTpPQPIRVEKIVTDSPAFHEGtIQVGDVILAANRTPLDRSSYEHALNVLRSL
.  |.|... || ||   ..| | ..| ...|   | ...||.||. | ...   | ..| ..... 
krgglGfslkggsdkr.dkgifvsevvpggaaeadg.lkeGDkIlsvNgvdvenvshdeavqaikgk
PDZ PDZ domain (Also known as DHR or GLGF) 1747-1810 2.6e-13 40.1 Pfam-A 11-77 (81) alignment 
Range on Protein: 1747-1810
Range on HMM: 11-77/81.0
TFGFSIAGGGDR---PIYVKKVSPMTPAALGGLSRHDVLLEVNGHDVRLMDRPDLLKVIKEHKGQLR
 .|||..|| |    .|.|..|.|. .|. .||. .|..|.||| ||. .   .  ..||. ||...
glGfslkggsdkrdkgifvsevvpggaaeadglkeGDkIlsvNgvdvenvshdeavqaikgkkgevt
PDZ_2 PDZ domain 1758-1806 2.1e-06 17.1 Pfam-A 14-60 (82) alignment 
Range on Protein: 1758-1806
Range on HMM: 14-60/82.0
RPIYVKKVSPMTPAALGGLSRHDVLLEVNGHDVrlMDRPDLLKVIKEHK
| ..| .| . .|||  ||   |..|.|.|..|   ...|| ...  .|
rgvlvvsVkessPaakaglkpGDiilkvdgkkv..ksltdlkslllkkk
PDZ PDZ domain (Also known as DHR or GLGF) 1977-2056 1.3e-14 44.2 Pfam-A 2-78 (81) alignment 
Range on Protein: 1977-2056
Range on HMM: 2-78/81.0
VVLDKTQDGGLGLRFQAQRDDTtgSQVVSIKEVCAGGAAERAGtLRAGDILVSVNGQALAGKKPREIIDALSSASGLVRM
|.| | . ||||.. . ..|.   .. . ..|| .|||||..| |..||...||||. ...    |...|. ...| |..
vslekekrgglGfslkggsdkr..dkgifvsevvpggaaeadg.lkeGDkIlsvNgvdvenvshdeavqaikgkkgevtL
PDZ_2 PDZ domain 1985-2035 9.4e-08 21.5 Pfam-A 1-46 (82) alignment 
Range on Protein: 1985-2035
Range on HMM: 1-46/82.0
GGLGLRFQAQRDdTTGSQVVSikeVCAGGAAERAGtLRAGDILVSVNGQAL
|..| ... ... |.|  |||   |  .. |..|| |..|||...|.|...
gdiGvsvsqlen.trgvlvvs...VkessPaakag.lkpGDiilkvdgkkv
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2140-2384 5.1e-21 69.6 In-house 6-248 (303) alignment 
Range on Protein: 2140-2384
Range on HMM: 6-248/303.0
ARKWELLKIALLDAMQQqQPADEYTEL-NNMRPQLTTRVGQSHMAANRYRDILPCDETRVKLGAEGYINANLVQLpvapgENRHQAILCQGPLPETCADM
 .|| ||   .||   .   ..|. .. . . |... .   . |  ||. |..  | ..|||    || |. ..|     . ...||| | ||. |.||.
kqkwkllakrtldedan.iavnefekvvsylppsvsknqfvknmdknrfvdvicldhskvklsdssyihasylel.....dsskkailtqlplshtaadf

WQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKR-KKVTARNFTIENLGVVK-KSGFNVSTLQVhdsASGASREVMHFQ-FIDWPDHGVPSS-AAQMVQ
|||. ||  ...... .. |  ..  .  .|  .   |   |   . ..  |.   |...  | |   . |  .  .| . . .||   .||  ....|.
wqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsv...sngdyksflhvhhykawphnsipsdgspkfvk

MLREV--ALFQTSDAGPMAVHCSAGIGRSGVFVTLYTVLLALTLPLRALDVV
 . ..   | . ||. |      .| ||.| |  . |  |.|     .||.|
qiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2141-2428 6.9e-21 68.9 In-house 8-284 (302) alignment 
Range on Protein: 2141-2428
Range on HMM: 8-284/302.0
RKW--ELLKIALLDAMQQQQPADEYTELNNMRPQLTT-RVGQSHMAANRYRDILPCDETRVKLG--AEGYINANLVQLPVAPgenrHQAILCQGPLPETC
.||  |  ...| . .....  .|. ....|. .|   .. ..... |.  |.   |...|||.  .. |.||  |..|       .. || | |  .. 
ekWveeeeakklvksldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPelt....rsiilaQlpkvdse

---ADMWQMVWEQDTRVIVMVTSEKEKGHiKCHRYWPVRKRKKVTARNFTIENLGVVKKSGFNvSTLQVHDSASGASREVMHF--QFIDWPDHGVPSSAA
   .. |.||...    .|..  |.|  .   . ..| .  . ... .. . |  | |... . . . .     | |  |.     .  |... || . |
dsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkya

QMVQMLREVALFQTSDAGPMAVHCSAGIGRSGVFVTLYTVLLALTlplraldvvaREhfeyTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYVTL
....   .|   ...   ....    |.|| |.|.|| ...  |.          ..        .||||...|.|| |..|.. .|| ..| | ...
eliktaakvfakkikadentvivSknGaGRagafltlavaveklq..........kg....kepnikeivksiRsqR.pravdslkQyvslyiallly
0039614 (Phosphotyrosine protein) phosphatases II 2147-2430 3.1e-73 242.2 In-house 22-290 (297) alignment 
Range on Protein: 2147-2430
Range on HMM: 22-290/297.0
KIALLDAMQQQQPADEYTELNNMRPQLTTRVGQSHMAANRYRDILPCDETRVKLGA-------EGYINANLVqlpvaPGEN--RHQAILCQGPLPETCAD
 . |..|.. ..   |. || .. |  ..   . ..  |||.||||.| .||||           ||||..|     .| .   .. |..|||||||..|
llllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv.....dgydlltrkfIatqgPlpetved

MWQMVWEQDTRVIVMVTSEKEKGHiKCHRYWPVRKRkkvTARNFTIENLGVVKKSGFNVSTLQVHDsaSGASREVMHFQFIDWPDHGVPSSAAQMVQMLR
 |.|||||...||||.|...|.|. ||..||| .     |  .||...|.| ...|..| || | .  .| ||.|.|||...|||||||.|.... ..|.
FwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllefle

EVALFQTS--DAGPMAVHCSAGIGRSGVFVTLYTVLLALTlplraldvvarehfEYTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYVTLLG
.|  .. .  . ||..||||||.||.|.|...|..|  |               ..  . |.|.|..||||| | .||| .|| |.|.| . || 
lvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqle..............keggvdvleavkelreqR.pgavqtpsqyrflydallellk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2147-2428 5.4e-58 191.3 In-house 11-278 (288) alignment 
Range on Protein: 2147-2428
Range on HMM: 11-278/288.0
KIALLDAMQQQQPADEYTELNNMRPQLTTRVGQSHM--AANRYRDILPCDETRVKLGA------EGYINANLVQlpVAPGENRHqaILCQGPLPETCADM
|.|  .|.....  .||  | ..  . .. .|.       ||||.||| ||.||||        . ||||. ..  .  .....  |  ||||..|  | 
kvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyid..gekkkkky..iatqgPladtvndf

WQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRKkVTARNFTIENLGVVKKSGFNVSTLQVHdsASGASREVMHFQFIDWPDHGVPSSAAQMVQMLRE
|..|.|..|  |||.|.  |.|. ||..|||  ... .   ..|.. ... ..  | . .| ..   ..  .|. ..|.  ||||||| |.|.....|| 
WelvyenktstivmltelveggktkCeeYWPdadkp.knyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrq

VALFQTSDAGPMAVHCSAGIGRSGVFVTLYTVLLALTLplraldvvarehfeYTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYVTL
|   ...|.||. ||||||.||.|.|..| ... |.                .  | | ..|.|||.|| ...||| .|| |.|.. ..|
vkvanqadtgpiivhCsaGvGrtgtFialdalidavee..............edyiDvagtvaklRkqR.allvqtlkqYefiyevllsl
subfamily_PTPRK_pd Subfamily PTPRK 2147-2426 6e-46 151.7 In-house 12-274 (314) alignment 
Range on Protein: 2147-2426
Range on HMM: 12-274/314.0
KIALLDAMQQQQPADEYTELNNMrpqLTTRVGQSHMAANRYRDILPCDETRVKLGA------EGYINANLVqlpvaPGENRH-QAILCQGPLPETCADMW
.|||| . .     .||  | .      .   . . . ||. |||. | .||.| .        ||||.|.      . .|  . |  ||||.|| .|.|
siallkraegygfkeeyeslfeg...wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaali.....dsykrpaafivtqgPlqetvkdfW

QMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRKkvtARNFTIENLGVVKKSGFNVSTLQVHD--SASGASREVMHFQFIDWPDHGVPSSAAQMVQMLR
..|.....  |||.|  .|.|..|| .|||   ..     .. .| . .  .. . | ...|.    .  . ||| .|||. ||||.|| ||  .....|
rlvydencasivmltelvevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvr

EVALFQTSDAGPMAVHCSAGIGRSGVFVTLYTVLlaltlplralDVVAREHFeytsIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYV
.|   |  .||.. |||||| ||.|.|... .||          |.. ||.     . | ..|..||... . .|.| ||| |.| . .
rvkksqeeeaGrivvhCsaGaGrtGtfiaidivl..........dmieregv....vdvfnavktlrsrk.vnmveteeqykfiydvil
subfamily_PTPN13_pd Subfamily PTPN13 2148-2432 1.2e-129 426.3 In-house 2-272 (273) alignment 
Range on Protein: 2148-2432
Range on HMM: 2-272/273.0
IALLDAMQQQQPADEYTELNNMRPQLTTRVGQS--HMAANRYRDILPCDETRVKLGAEG-YINANLVQLPVapGENRHQAILCQGPLPETCADMWQMVWE
.|| ....|||||.|..||....|..|..||..  ....||||..||.||||||||.|| ||||.|...||  |......|.||||||||..|.||||||
aalqkkldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdeggyinaslikvpv..gkdeyeyiacqGPlPetvkdfwqmvwe

QDTRVIVMVTSEKEKGHIKCHRYWPVRKRKKVTARN-FTIENLGVVKKSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQ
|...||.|||.|||||..|||||||..|.||....| ...|.|.|.|..||.|..|.|.||.||.||||.|..|..|||||||||||...|...||. .|
qkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlq

TsDAGPMAVHCSAGIGRSGVFVTLYTVllaltlplraLDVVAREHfeytSIPVKEIVQKLREQRHpSVVQTSEQYLFVYKAYVTLLGML
| ||||..|||||||||||...|...|          |....|..    ...|||||.||||||. .||||..||.|||||....|..|
t.dagPivvhcsaGiGrsGtlitidvv..........lglierdk....efdvkeivrklreqrq.gvvqtkdqyifvykailevlksl
0050432 (Phosphotyrosine protein) phosphatases II 2149-2428 4.6e-76 251.4 In-house 34-298 (308) alignment 
Range on Protein: 2149-2428
Range on HMM: 34-298/308.0
ALLDAMQQQQPADEYTELNNMRPQLT--TRVGQSHMAANRYRDILPCDETRVKLG-AEGYINANLVQLPVapGENRHQAILCQGPLPETCADMWQMVWEQ
.| .|.. ..   |. ||... | |.  .   . ..  |||.||||.| .||||.   .||||..|....    .... |..|||||.|..| |.|||||
llekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgys..sklprkfIatqgPlpntvedFwrmvweq

DTRVIVMVTSEKEKGHIKCHRYWPVRKR-KKVTARNFTIENLGVVKKSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQt
..|||||.|.. |.| .||..|||     . ..  .||...| . ..... | ||.. .. .| ||.|.||....|||||||.|.......|..|  .. 
nvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.

sDAGPMAVHCSAGIGRSGVFVTLYTVLLALTLplraldvvarehfeYTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYVTL
 . ||..||||||.||.|.|..|...|  |                   . | |.|.|||||| | .||| |||||.|.| . .
.pggpivVHCsaGvGRtGtfialdllleqlek..............eggvdvfeavkklReqR.pgmvqtpeqylflyralley
subfamily_PTPRD_pd Subfamily PTPRD 2151-2426 2.7e-68 226.0 In-house 17-278 (564) alignment 
Range on Protein: 2151-2426
Range on HMM: 17-278/564.0
LDAMQQQQPADEYTELNNMrPQLTTRVGQSHM--AANRYRDILPCDETRVKL----GAEG--YINANLVQlpvaPGENRHQAILCQGPLPETCADMWQMV
|.| ....   || ....  .| |... . ..  | ||| .|.. |..||.|    | ||  ||||. ..      ..|.. |  ||||.||..| |.||
lkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfid....gyrkrkayIAtqgPlaetiedFWRmv

WEQDTRVIVMVTSEKEKGHIKCHRYWPVRkRkKVTARNFTIENLGVVKKSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALF
|||....|||.|. .|||. |||.||| . . . |  ..|..    .... . . |...... |  |||| .|.|..||||||| ||.......|.|   
weqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvral

QTSDAGPMAVHCSAGIGRSGVFVTLYTVLLALTlplraldvvaREhfeyTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYV
...||||. ||||||.||.|.|...  .|  ..           |      . . ..|..||.|| . .||| ||| |...| .
nepdagPivVhCSaGVGRTGtfividamlerik..........ee....ktvDiyqyvkalrkqR.namVqteeQYiFiheail
subfamily_PTPN9_pd Subfamily PTPN9 2151-2426 2e-58 192.8 In-house 10-287 (297) alignment 
Range on Protein: 2151-2426
Range on HMM: 10-287/297.0
LDAMQQQQPADEYTELNNMRPQLTTRVGQS--HMAANRYRDILPCDETRVKLGAE------GYINANLVQlpvapGENRHQA-ILCQGPLPETCADMWQM
. .....    ||.|. |. .. |  . ..   .  ||| |.|  |||||.|  .       ||||| |.     | ....| |  ||||..|. | |.|
vkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvd.....GykqkkafiatqGplkktvsdfWrm

VWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRKKVTARNFTIENLGVVKKSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVAL
||||...||||.|   |.|..|| .|||  . .     .....|. |.... ..|..|.....  . ||.|.||||. |||.|||||||.....|..|  
vWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvre

FQTS-------------DAGPMAVHCSAGIGRSGVFVTLYTVLLALtlplralDvvarehfEYTSIPVKEIVQKLREQRHPSvVQTSEQYLFVYKAYV
 |..             .  |. |||||||||.| |.||   |  |       .       | . . | | |..||.||  | .|| ||| | |.| .
kqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrl.......e.......evgtvdvvetvkllrtqrafs.iqtpeqyefcylavl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2151-2426 1.7e-29 97.6 In-house 14-276 (439) alignment 
Range on Protein: 2151-2426
Range on HMM: 14-276/439.0
LDAMQQQQPADEYTELNNMRPQ---LTTRVGQSHMAA-NRYRDILPCDETRVKL------GAEGYINANLVQLPVapgeNRHQAILCQGPLPETCADMWQ
||  .|.   ... ..| ..|.    .. . |..  . |||.|. . | ||| |          ||||| ..       . .  | .|||  ||. |.|.
ldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy....ddklyiatqgpkkettddfwr

MVWEQDTRVIVMVTSEKEKGHikchrYWPVRKRKK---VTARNFTIENLGVVKKSGFNVstLQVHDSaSGASREVMHFQFIDWPDHGVPSSAAQMVQMLR
.|.|. |  |||.|   |  .     |||  .      .. |     .|      ||.|  .. .|. .   | |..|..| |||. ||. |. ....||
lviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkv..fnerdt.tekertvlqfhyiawpdknvpaqashvldflr

EVALF-QTSDAGPMAVHCSAGIGRSGVFVtlytvllALTLPLRALDVvarEhfeyTSIPVKEIVQKLREQRHpSVVQTSEQYLFVYKAYV
 .    .. . ||. ||||||.||.|  .       || . |  | .   |      . .| ||. ||.||.  .||.  ||.|.|.| .
ainsandkeeygpvvvhcsagvGrtGtii.......aldialeqlkl...e....nkvdikgivkvlrkqrk.qmvqalcqyvfiynavl
0040438 (Phosphotyrosine protein) phosphatases II 2152-2428 2.9e-75 248.8 In-house 13-275 (317) alignment 
Range on Protein: 2152-2428
Range on HMM: 13-275/317.0
DAMQQQQPADEYTELNNMRPQlTT--RVGQSHMAANRYRDILPCDETRVKLGA------EGYINANLVQLPvapgENRHQAILCQGPLPETCADMWQMVW
.... ... .|. .| .. .  |.     . ..  |||.||||.| .||||         .||||..|. |    . ... |..|||||.|..| |.|||
lksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgp....nlkrkfIatqgPlpntvedFwrmvw

EQDTRVIVMVTSEKEKGHIKCHRYWPVrkRKKVTARNFTIENLGVVKKSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQ
||...||||.|...|.| .||..|||   ....|  .||...|......|... ||.| |. .. ||.|.||....|||||||.|  .....|..|  ..
eqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

TSDAGPMAVHCSAGIGRSGVFVTLYTVLLALTlplraldvvarehfEYTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYVTL
 .. ||..||||||.||.|.|...|..|  |               ..  . |.|.|..||||| | .||| ||| |.|.|   .
edpggpvlVHCsaGvgRtGtfiaaylmleqle..............keggvdveeavkelreqR.pgavqtpeqyrflydalley
0036941 (Phosphotyrosine protein) phosphatases II 2152-2428 1.9e-73 242.7 In-house 8-276 (297) alignment 
Range on Protein: 2152-2428
Range on HMM: 8-276/297.0
DAMQQQQPADEYTELNNMRPQLTTRV--GQSHMAANRYRDILPCDETRVKLGAEG--YINANLVQLPvapgENRHQAILCQGPLPETCADMWQMVWEQDT
.... ..   |. || .. .. ...|   . ..  |||.||||.| |||||. ||  ||||..|...    .  .. |..|||||.|..| |.|||||..
kllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgy....dlkrkfIatqgPlpntvedFWrmvweqnv

RVIVMVTSEKEKGHIKCHRYWPVRKRKKVTARNFTIENLGVVK--KSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTS
.||||.|.. |.| .||..|||  ... .|  .||...|.| .  .... . ||.| |  .| ||.|.||....|||||||.|.|........|  ..  
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

--DAGPMAVHCSAGIGRSGVFVTLYTVLlaltlplraldVVAREHFEYTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYVTL
  . ||. ||||||.||||.|......|              ... ..  ....|.|.|||||| | .||| |||.|.| |   |
lpsggpvlVHCsaGvgRsgtfiaadlml...........qqledklkeggvdileavkklReqR.pgavqtleqyrflyeallel
subfamily_PTPN3_pd Subfamily PTPN3 2152-2426 2.6e-66 218.4 In-house 10-272 (280) alignment 
Range on Protein: 2152-2426
Range on HMM: 10-272/280.0
DAMQQQQPADEYTELNNMRPQLTTRVGQ--SHMAANRYRDILPCDETRVKLGAEG--YINANLVQLPVAPGENRHQAILCQGPLPETCADMWQMVWEQDT
..... .   .. .|   .|.|.. . .    .. |||||||| |.||||| ..   ||||| |.. .   .   . | .||||..|..|.|||||||..
eglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqks

RVIVMVTSEKEKGHIKCHRYWPVRKRKKVTArNFTIENLGVVKKSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSDA
..|||.|.  |.|..|||.|||  . .   . .|...     ... . .  | ..|...  .|.....|...|||||||...|........|   .... 
slivmlttlverGrvkChqyWPetedeleyg.efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgke

GPMAVHCSAGIGRSGVFVTLYTVLLaltLplraldVVAREhfeytSIPVKEIVQKLREQRHpSVVQTSEQYLFVYKAYV
 |. |||||||||.||...| | |    |      . |.|     .. . .||...|.||  ..|||..|| || .| .
ePvvvhCsaGigrtGvlilletala...l......ieaae.....pvypldivrtmrdqra.mlvqtasqykfvCeail
subfamily_PTPN6_pd Subfamily PTPN6 2152-2425 6.3e-60 197.7 In-house 21-293 (306) alignment 
Range on Protein: 2152-2425
Range on HMM: 21-293/306.0
DAMQQQQPADEYTELNNM--RPQLTTRVGQ--SHMAANRYRDILPCDETRVKL---GAEG--YINANLVQlPVAPGENrHQAILCQGPLPETCADMWQMV
. ....   .|. ||...  . .|. . |.  . .  |||. ||| |.|||.|   .  |  ||||| ..   ..|.. .. |  || |..| .| |.||
eslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyik.kevkgsd.ksyiatqgclettvsdFWrmv

WEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRKKVtARNFTIENLGVVKKSGFNVSTLQV-HDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVAL
|....|||||.| | |.|. || ||||  ..|.    . ...|.   ... ... .|.| . . .. .|||....| .|||||||..  .....|..|  
wqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnr

FQ----TSDAGPMAVHCSAGIGRSGVFVTLYTVllaltlplraLDVVAREHFEYtSIPVKEIVQKLREQRHpSVVQTSEQYLFVYKAY
 |    ...|||. ||||||||| | |. . ..          |... .. ...  | ....|...||||   .||| .|| ||||| 
kqeeleeaeagpivvhCsaGiGRtGtfiviDil..........lkliekkglda.didiqklvksvreqrs.glvqteqqykfvykai
subfamily_PTPN14_pd Subfamily PTPN14 2153-2429 2.8e-56 185.7 In-house 19-296 (300) alignment 
Range on Protein: 2153-2429
Range on HMM: 19-296/300.0
AMQQQQPADEYTELNNMRPQLTTRVGQSH--MAANRYRDILPCDETRVKLG-----AEGYINANLVQLPVApgENRHQAILCQGPLPETCADMWQMVWEQ
 ... .   || .. ..| . .. ...       ||..|.|| ...||.|       .|||||  .. .|.   .... | .||||. |. |.|||||||
kleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvg..gkersyivaqgPleltvqdfWqmvWeq

DTRVIVMVTSEKEKGHIKCHRYWPVR--KRKKVTARNFTIENLGVVKKSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQ
....|||.|.|.|.|. |...|.|    |.|.|.  .| . .  . . . .  ..|...   |.  |.|.|.|..||||||||.   .... |.||   .
gvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvr

---TS------DAGPMAVHCSAGIGRSGVFVTlyTVLLALTLplraldvvarEHFEytSIPVKEIVQKLREQRHpSVVQTSEQYLFVYKAYVTLL
   .|         |. ||||||.||.|| ..  . ||  ||          || |  .| .|.....|||||  ..|||  || ||||. .. |
rktnseveskeskPPvlvhCsaGvGrtGvlil..sdlliatl..........ehne..eidikkvlarLreqrm.llvqtlaqYkfvYkvlikyl
0047943 (Phosphotyrosine protein) phosphatases II 2155-2426 4.2e-72 238.2 In-house 10-269 (273) alignment 
Range on Protein: 2155-2426
Range on HMM: 10-269/273.0
QQQQPADEYTELNNMRPQLT--TRVGQSHMAANRYRDILPCDETRVKL--GAEGYINANLVQLPvapgENRHQAILCQGPLPETCADMWQMVWEQDTRVI
. .. . |. .| .. |.||  . . . ..  |||.||||.| .||||  |  .||||..|...    .  .. |..|||||.|..| |.|||||..|||
gltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgy....nlkrkfiatqgPlpntvedfwrmvweqnvrvi

VMVTSEKEKGHIKCHRYWPVRKRK-KVTARNFTIENLGVVKKSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTS--DA
||.|.. |.| .||..|||    . ..|  .||...|.. .|... | ||.. .. .| ||.|.||.. .|||||||.| .........|  .. .  . 
VmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn

GPMAVHCSAGIGRSGVFVTLYTVLLALTLplraldvvarehfeYTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYV
||..||||||.||.|.|..|...|  |                .  . |.|.|..||.|| | .||| |||.|.|.| .
gpvvVHCsaGvgRtgtfialdllldqlek..............eggvdvleavkllrsqR.pgmvqtpeqyrflyeall
subfamily_PTPRB_pd Subfamily PTPRB 2155-2429 4.3e-63 208.1 In-house 23-285 (293) alignment 
Range on Protein: 2155-2429
Range on HMM: 23-285/293.0
QQQQPADEYTELNNMRPQLTTRVGQS--HMAANRYRDILPCDETRVKL------GAEGYINANLVqlpvaPGE-NRHQAILCQGPLPETCADMWQMVWEQ
.. . ..|| ||...  . .. . ..    | |||..||| |..||||        . ||||| .     ||   ... | .|||||||  |.|.||||.
sdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyi.....pgynsprefiatqGPlpetvddfWrmvwek

DTRVIVMVTSEKEKGHIKCHRYWPVRKrKKVTARNFTIENLGVVKKSGFNVSTLQVHDsaSGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQ--
 ...|||.|   |||..||..|||  . . |.  . ... .   ... . . .|...   . ..|.|....|. |||||||..........|.|   .  
kssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiek

TSDAGPMAVHCSAGIGRSGVFVTLYTVLLALTLplraldvvarehfeYTSIPVKEIVQKLREQRHpSVVQTSEQYLFVYKAYVTLL
|....|. ||||||.||.|.|..| ..| |..                  . .  ||..|||.|  ..||| .||.|.... ..||
taskrPivvhCsaGvGRtGtfialdrllqaiee..............edyvdifgivaelReeRn.llvqtekqYifihqcvldll
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2155-2427 5.4e-54 178.5 In-house 25-288 (298) alignment 
Range on Protein: 2155-2427
Range on HMM: 25-288/298.0
QQQQPADEYTELNNMRP---QLTTRVGQSH--MAANRYRDILPCDETRVKLGA------EGYINANLVQlpvaPGENRHQAILCQGPLPETCADMWQMVW
.  . |.|. .||..     . ...|....     ||| ||.. | .|| | .        ||||  ..      ..|.  |..|.||.|| .| |.||.
kltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflh....aykgrnafiatqaPltetvedFWrmvt

EQDTRVIVMVTSEKEKGHIKCHRYWPVRKRKkvTARNFTIENLGVVKKSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALfQ
|.|  .|||.|. .|....|.|.||| .. .  |  ..|.. |   ... . | .|.|... .  .||| ...|. |||.|||. |  ....||.|   .
eedigtiVmltnleeldktkyhkywPdegke..tygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.s

TSDAG--PMAVHCSAGIGRSGVFVTLYTVLlaltlplralDVVAREHfeytSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYVT
...||  |. |.||||.|||| |. ...||          . | .|.    .. | ..|. ||..| | .||| ||| |.|.|   
qqqagnkpvivqCsaGvgRsGtfiaidsvl..........ervkkeq....vvDvfqvvkvlRkkr.pgavqteeqYvfiyeavle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2155-2428 2.6e-36 120.4 In-house 21-287 (325) alignment 
Range on Protein: 2155-2428
Range on HMM: 21-287/325.0
QQQQPADEYTELNNMRPQLTTRVGQ-SHMAANRYRDILPCDETRVKLG------AEGYINANLVQLpvapGENRHQAILCQGPLPETCADMWQMV--WEq
.|.  | |.  | .  ..  .  ..   .| ||...... |..|| |          ||||. ..       ...  . .| ||..|  |.|..|  |. 
dqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrd....dkkkdvflaaqaPltatindlWrlvldWr.

dTRViVMVTSEKEKGHIKCHRYWPVRKRKKVTARNFTIENLGVVKKSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLR------EV
 . | |.|. | ..|. .|  ||| .  | .|   . ..   . . | .    |.| .   | .| |  ||.  |.| ||.   | .. .|.      | 
.csv.vvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavser

ALFQTSDAGPMAVHCSAGIGRSGVFVTLYTVLlaltlplraldvvaREHFEYTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYVTL
   .|  ..|. ||||||.||.|||..||..|               .  | ... . . |.|||..| ||.|.| .|| ..|.| |  
vtantkastpilvhcsaGvGrtGvfislysal..............akvieesrvdifgfvkklrkdr.psmvetvdqyiliyealvea
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2156-2424 2.7e-39 130.0 In-house 15-272 (307) alignment 
Range on Protein: 2156-2424
Range on HMM: 15-272/307.0
QQQPADEYTELNNMRPQ-LTTRVGQSHMAANRYRDILPCDETRVKLGAEG----YINANLVQLPVAPgenrHQAILCQGPLPETCADMWQMVWEQDTRVI
 |.  ||...| .. |. .|.   ..    |||.|.   | .|. .  .|    || || . . . |    .. | .|||| .|  ..| |. ...   .
vqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikp....kkficaqgplentqysfwamaiqekvesv

VMVTSEKEKGHIKCHRYWPVRKRKKVT----ARNFTIENLGVVKKS----GFNVSTLQVHdsASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREValf
.|.    | ..|||..|||. . .| .    ..  ...|||. | .      ||.||.|    .. || . |.|. .|||.|||      . .|  |   
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvd..waqksrtiqhlqwenwpdrgvpqinltainlleav...

qTSDAGPMAVHCSAGIGRSGVFVTLYTVLLALtlplraldvVAREhfeyTSIPVKEIVQKLREQRHPSvVQTSEQYLFVYKA
   |  |. ||||||.||||  |..  |   .         .| .        .|..|..||.||| . .||  |||.... 
.rydtnpvvvhcsaGvGrsGtivaislvqdkm.........iaGi....nckdmkklveelrsqrhya.iqteaqylylhrv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2156-2424 1.1e-23 78.4 In-house 18-271 (312) alignment 
Range on Protein: 2156-2424
Range on HMM: 18-271/312.0
QQQPADEYTELNNMRPQLTTRVGQSHMAANRYRDILPCDETRVKLGAE--GYINANLVQLPVAPgenrHQAILCQGPLPETCADMWQMVWEQDTRVIVMV
 || . ||  . |. ..            ||| .|   |  |  |  .   || ||.|..   |     . . .|||| .||. .||..    .  |...
pqqltkeykavgnivsdsectaflkfkdlnrypniqcwdrgrftlagdenfyihanfvkictkp....erfvctqgplentcthfwqlalslgstsiill

TSEKEKGHIKCHRYWPV------RKRKKVTARNFTIENLGVVKKSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREValfqTSDA
..  | |  || .|          . ..| .   |  ..|   |       |.|   |.|    . |.|.  |||||.| |     ..|  |      | 
cgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsav....kkdk

GPMAVHCSAGIGRSGVFVTLYTVLLALTLPLRAlDvvarehfeytsipVKEIVQKLREQRHPSvVQTSEQYLFVYKA
 |.  |||||.||.| .. . ... ||  | .  .             ||..   || .|  | |..  ||... ..
kpviahcsagvgrtgtlaliesmiaalrhprkq.n.............vkdsfvllrkdrars.vrvfpqyvyalrc
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2157-2431 9.1e-34 111.5 In-house 15-295 (301) alignment 
Range on Protein: 2157-2431
Range on HMM: 15-295/301.0
QQPADEYTELNNMRPQ-LTTRVGQSHMAANRYRDILPCDETRVKLGAE--------GYINANLVQlpvaPGENRHQAILCQGPLPETCADMWQMVWEQDT
.. ...|.||......  |  . ... |.||...| . |. |. |  .         ||||. ..       .... |  |||. .| .|.|...|.. .
nkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyid....gysekkkfiaaqgpmkktlvdfWrliwqekp

RVIVMVTSEKEKGHIKCHRYWPVRKRKKVTAR-------------NFTIENLGVVKKSGFN----VSTLQVHDSAsgASREVMHFQFIDWPDHGVPSSAA
  ||||| .||. . ||..|||  . .. .               .|.| .| |. . |.|     ....|. .   .|..|. .| .|||..||    .
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvrepr

QMVQMLREVALFQT-SDAGPMAVHCSAGIGRSGVFVTlytVLLaltlplrALDVVAREHFeytsIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYVTLL
 ..| . .|   |   . ||. ||||....||||...   | .       .|. . .|      . | .... .| .. | .|.| ||| ..|... . |
tvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcs...vsi.......glEQckaegV....Vdvfqvtkavrrsk.pgaVtTLeqytsiydvidmyl

GM
 .
ql
0051299 (Phosphotyrosine protein) phosphatases II 2158-2424 1e-73 243.6 In-house 24-281 (288) alignment 
Range on Protein: 2158-2424
Range on HMM: 24-281/288.0
QPADEYTELNNMRPQLT--TRVGQSHMAANRYRDILPCDETRVKLG------AEGYINANLVQLpvapGENRHQAILCQGPLPETCADMWQMVWEQDTRV
. ..|. || .. |.||  . . . ..  |||.||||.| .||||         .||||.....     .. .. |..|||||.|..| |.|||||..||
glleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidg....ynlkrkfIatqgPlpntvedFWrmvweqnvrv

IVMVTSEKEKGHIKCHRYWPVrkRKKVTARNFTIENLGVVKKSGFNVSTLQVHDS----ASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTS
|||.|.. |.| .||..|||   ....|  ..|...| ....... | ||.| .      .| ||.|.||....|||||||.|. .....||.|  .. |
IvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalas

DAGPMAVHCSAGIGRSGVFVTLYTVLLALTlplraldvvarehfEYTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKA
. ||..||||||.||.|.|..|...|  |               .   . | |.|..||||| | .||| |||.|||.|
gggpvvVHCsaGvgRtgtfialdllleqle..............keggvdvleavkrlreqR.pgmvqtpeqyrfvyea
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2158-2429 1.8e-59 196.2 In-house 16-276 (281) alignment 
Range on Protein: 2158-2429
Range on HMM: 16-276/281.0
QPADEYTELNNMRPQLTTRV--GQSHMAANRYRDILPCDETRVKL------GAEGYINANLVQlpvaPGENRHQAILCQGPLPETCADMWQMVWEQDTRV
  . ||..|...  . |..    .  .  |||..|   | ||||.          ||||| |.      .. .. | .|||.|......|||||||. ..
GfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvp....gykgekeyiatqgPvPaslvafWqmvweqkvsa

IVMVTSEKEKGHIKCHRYWPvRKRKKVTARNFTIENLGVVKKSGFNVSTLQVhDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSDA-G
||||| | |.|..|||||||  ......  ..|....   .|. .   .... .  || .||| ..... |||||||........  .||  .....   
ivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktka

PMAVHCSAGIGRSGVFVTLYTVLlaltlplralDVVAREHfeyTSIPVKEIVQKLREQRHpSVVQTSEQYLFVYKAYVTLL
|. .|||||.||.|....| ...          . |..|.   ... ||..|..||..|   .|||  || ||||| .  |
plvihCsaGvGrtGtyialDrlv..........kaveael...eeldvkavvaelrkern.lmvqtvvqyefvykavldal
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2158-2427 5.6e-51 168.5 In-house 24-281 (319) alignment 
Range on Protein: 2158-2427
Range on HMM: 24-281/319.0
QPADEYTELNNMRPQLTTRVG-QSHMAANRYRDILPCDETRVKLGA------EGYINANLVQlpvaPGENRHQAILCQGPLPETCADMWQMVWEQDTRVI
. . |. .|..  .. ..    .     |||..||..| |||.| .        ||||. ..      ..|.. |  |.|| .|  |.|.||||... ..
llekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfid....gyqerekfiatqaPlentiedfWrmvWeeessiv

VMVTSEKEKGHIKCHRYWPVRKRkkVTARNFTIENLGVVKKSGFNVSTLQVHDSASGA-SREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTS-DAG
||.|  .||...|...|||  .   ..  ..... .   ..... .. |...  .|   .|||.|||. .||||.|| .| .....|....  .   ..|
vmltklveklkvklkkywpeenf..eeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsg

PMAVHCSAGIGRSGVFVTLYTvllaltlplrALDVVAREhfeyTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYVT
|. ||||||.|| | |..|            .|. | .|    . . | ..|..|| || . .||. ||| |.|.| . 
PivvhCsaGvGRtGtfivlda..........mlervkee....gvlDvfstvsrlRtqR.nimvqrpeqYkfiyealle
subfamily_PTPRA_pd Subfamily PTPRA 2159-2425 2e-48 160.0 In-house 34-291 (330) alignment 
Range on Protein: 2159-2425
Range on HMM: 34-291/330.0
PADEYTELNNMRPQLTTRVG--QSHMAANRYRDILPCDETRVKLGA-EGYINANLVQLPVAPG-ENRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVT
  .|.  |   . | |  .   .  .  ||. .||| | .|| |   ||  ... .      | ..... | .|||. ||  |.|.|.|||..  |||.|
freefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmlt

SEKEKGHIKCHRYWPVRkrKKVTARNFTIENLGVVKKSGFNVSTLQVH---DSA-SGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSDAGPM
  ||. . ||..|||      ||  | ..|   ..    . |  . |.   |..   .|| |  | |  ||| |||. .  |...|..|   .   |||.
elkerkeekcaqywPde..GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpi

AVHCSAGIGRSGVFVTLYTVLlaltlplralDVVAREhfeyTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAY
 ||||||.||.| |..| .||          . |  |      . | |.|..|| || | .||| ||| |.||. 
vvhcsaGvGrtGtfivldavl..........ervkae....rkvdvfefvkrlrlqr.pqmvqtdeqyefiykvl
0045450 (Phosphotyrosine protein) phosphatases II 2160-2426 1.8e-72 240.0 In-house 30-301 (307) alignment 
Range on Protein: 2160-2426
Range on HMM: 30-301/307.0
ADEYTELNNMRP----QLTTRVGQSHMAANRYRDILPCDETRVKL-------GAEGYINANLVQLPVA----PGENRHQAILCQGPLPETCADMWQMVWE
. |. .|... .      ..   . ..  |||.||||.| |||||       .  .||||. | .|.        . .. |..|||||||..| |.|.||
lkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlwe

QDTRVIVMVTSEKEKGHIKCHRYWPVRkRKKVTARNFTIENLGVVKKSGFNVSTLQVHDS-ASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQ
|...||||.|...|.|..||..|||   . ..| .|||...|.. ...|. | || |.|.  .| ||.|.||....|||||||.| ........||  ..
qgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkal

TS--DAGPMAVHCSAGIGRSGVFVTLYTVLLALTL-------PlraldvvarehfeytsipVKEIVQKLREQRhPSVVQTSEQYLFVYKAYV
 .  . ||..||||||.||.|.|...|..|  |         .                  . |.|..||||| | .||. ||| |.|.|  
eelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvd..................lleavkllreqR.pgavqnpeqyrflyeall
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2160-2426 3.6e-62 205.2 In-house 23-277 (318) alignment 
Range on Protein: 2160-2426
Range on HMM: 23-277/318.0
ADEYTELN--NMRPQLTTRVGQSHMAANRYRDILPCDETRVKLGAE------GYINANLVqlpvaPGENRHQA-ILCQGPLPETCADMWQMVWEQDTRVI
  || .|.  .  .  .  . .   | ||| .||. |.|||||          ||||| .     .| .|..| | .|.|||||. |.|.|||||...||
seeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyi.....dGyrrkkayiaaqaPlpetieDfWrmvWeqnsavi

VMVTSEKEKGHIKCHRYWPVRKRKKVtaRNFTIENLGVVKKSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQ-TSDAGP
||.| |.|.|..|.||||| .. ..    . ..|    |. | . . ...|. . . .||.|  ... .|||.|||.|.|......|.|   | .|.|||
vmltqeeergkakvhryWPskgsrsy..gklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagp

MAVHCSAGIGRSGVFVTLYTVLlaltlplralDVVAREhfeyTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYV
..||||||.|| |||... ..|          . .. |    . . | ..|..||||| . .||| .|| |.|.. .
ivvhCsaGvGrtGvfiavdill..........erikae....alvDvfqtvkqlreqr.nlmvqtedqyefiydvll
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2160-2426 1.8e-53 176.4 In-house 8-265 (274) alignment 
Range on Protein: 2160-2426
Range on HMM: 8-265/274.0
ADEYTELNNMRPQLTTRVGQsHMAANRYRDILPCDETRVKLGA-------EGYINANLVQlpvAPGENRHQAILCQGPLPETCADMWQMVWEQDTRVIVM
 .|. ||    .|  ..|   .   |||..||| ...|| | .         ||||| ..    ..|. .  .  |||||.| ||.|.|.......||||
ekeflelPlnfdqeeldvfg.sqtknryktilPnensrvllesessededssyinanyik...GydeeskayvatqGPlpntvadfWrmiyqeevqvivm

VTSEKEKGHIKCHRYWPVRKRKKVTAR--NFTIENLGVVKKSGFNVSTLQVHDSASgaSREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSD---A
.|  ||. . ||..|.| ..  ... |  .. |.. ..|.. ...| .| .. . .  .|.|.|. . ||||| .| .| .......||   ....   .
ltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenakl

GPMAVHCSAGIGRSGVFVTLYTVLLALTLplraldvvarehfeYTSIPVKEIVQKLREQRHpSVVQTSEQYLFVYKAYV
.|. ||||||||| |.|..    .  |                 . . | .|| .|| .|   .||||||| ....| .
apvvvhCsaGiGrtGcfiaisiavrqlre..............eivvdvlkivcnlrldrG.Gmvqtseqyelihralc
subfamily_Ptp69D_pd Subfamily Ptp69D 2160-2426 2.6e-46 153.2 In-house 25-283 (307) alignment 
Range on Protein: 2160-2426
Range on HMM: 25-283/307.0
ADEYTELNNMRPQLTTRVGQSH--MAANRYRDILPCDETRVKLGA------EGYINANLVQlpvaPGENRHQAILCQGPLPETCADMWQMVWEQDTRVIV
| || .|..   ...|.|.. .     ||| || . |.|||||          ||||. ..      ..... |  |.|. .|  | |.|..||.  .||
akeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfik....gykekkkfiaaqdPveatigDfWRmiaeqevtliv

MVTSEKEKGHIKCHRYWPVR---KRKKVTARNFTIENLGVVKKSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSDAG
|.. ..|| . ||..|||.    .  ..  .    |. .   .  ..||. . . .   .||.|. ...  |.|  || .|  .......|   .  . .
mlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrs

PMAVHCSAGIGRSGVFVTLYTVLLALtlplRAldvvarEhfeyTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYV
|. |||||| ||||.||.|  .|  |    .|      |     .. . |.|..||.|| . .||  ||| |.|.| .
PivvhCsaGvgrsgifvaldsllqql....ka......e....dkvdifetvkdLrsqR.nllvqsleqYvflyrall
0046845 (Phosphotyrosine protein) phosphatases II 2161-2428 2.8e-74 245.4 In-house 4-273 (284) alignment 
Range on Protein: 2161-2428
Range on HMM: 4-273/284.0
DEYTELNNMRP----QLTTRVGQSHMAANRYRDILPCDETRVKL-------GAEGYINANLVQLP-VAPGENRHQAILCQGPLPETCADMWQMVWEQDTR
.|. ||... .    .|.. . . ..  |||.|||| | .||||       .  .||||..|. . .    .... |..|||||.|..| |.|||||..|
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

VIVMVTSEKEKGHIKCHRYWPVRkRKKVTARNFTIENLGVVKKSGFNVSTLQVHDSA-SGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQT--S
||||.|.. |.|..||..|||    ...|  .||...| . .|... | ||.. .   .| ||.|.||....|||||||.|.......||.|  ...  .
vIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlp

DAGPMAVHCSAGIGRSGVFVTLYTVLLALTLPlraldvvarehfeyT---SIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYVTL
. ||..||||||.||.|.|..|...|  |                      ..| |.|..||||| |  ||| |||.|||.| . .
gggpivVHCsaGvgRtGtfialdllleqleke..............glllgvdvleavkrlreqR.pgmvqtleqyrfvyealley
DSPc_SM00195 2161-2427 1.8e-70 232.6 In-house 4-260 (263) alignment 
Range on Protein: 2161-2427
Range on HMM: 4-260/263.0
DEYTELNNMRPQLTTRVGQSH--MAANRYRDILPCDETRVKLGAE------GYINANLVQLPvapgENRHQAILCQGPLPETCADMWQMVWEQDTRVIVM
 |...|...... .|. .. .  .. |||..|||.|.|||||  |       ||||| ....    ..... |..|||||.|..| |.||||.....|||
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivm

VTSEKEKGHIKCHRYWPVRKRKKVTARNFTIENLGVVKKS-GFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSDAGPMA
.|.|.|.| .||.||||  . .| |  ......  | ||.  ... ||..   .   .|.| ..|. .|||||||.|. .....||.|   . .  ||. 
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

VHCSAGIGRSGVFVTLYTVLLALTLPLRaldvvarehfeytsIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYVT
||||||.||.|.|||. ..|  |.   .              . ..|||..||.|| |..|||.|||||.|.| . 
VhCsaGvgRtgtfvtidiilskleeekk..............vdifeivkelRkqR.pgmvqtleqYlfiyeaile
PTPc_SM00194 2161-2427 1.8e-70 232.6 In-house 4-260 (263) alignment 
Range on Protein: 2161-2427
Range on HMM: 4-260/263.0
DEYTELNNMRPQLTTRVGQSH--MAANRYRDILPCDETRVKLGAE------GYINANLVQLPvapgENRHQAILCQGPLPETCADMWQMVWEQDTRVIVM
 |...|...... .|. .. .  .. |||..|||.|.|||||  |       ||||| ....    ..... |..|||||.|..| |.||||.....|||
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivm

VTSEKEKGHIKCHRYWPVRKRKKVTARNFTIENLGVVKKS-GFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSDAGPMA
.|.|.|.| .||.||||  . .| |  ......  | ||.  ... ||..   .   .|.| ..|. .|||||||.|. .....||.|   . .  ||. 
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

VHCSAGIGRSGVFVTLYTVLLALTLPLRaldvvarehfeytsIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYVT
||||||.||.|.|||. ..|  |.   .              . ..|||..||.|| |..|||.|||||.|.| . 
VhCsaGvgRtgtfvtidiilskleeekk..............vdifeivkelRkqR.pgmvqtleqYlfiyeaile
0043336 (Phosphotyrosine protein) phosphatases II 2161-2426 3.8e-70 231.8 In-house 24-274 (278) alignment 
Range on Protein: 2161-2426
Range on HMM: 24-274/278.0
DEYTELNNMRPqL--TTRVGQSHMAANRYRDILPCDETRVKLGA------EGYINANLVqlpvaP-GENRHQAILCQGPLPETCADMWQMVWEQDTRVIV
 |. ||... .    ..   . ..  |||.||||.| .||||         .||||..|     .  .  .. |..|||||||..| |.||||.....||
lefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv.....dgynvprkfiatqgPlpetvedFwrmvwelgvttiv

MVTSEKEKGHIKCHRYWPvrkRKKVTARNFTIENLGVVKKSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSDAGPMA
|.|...|.|..||..|||   .. .|  .||...|.. ..... | || |..  .| ||.|.|.....|||||||.| ......|..|  .. .. ||..
mLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvl

VHCSAGIGRSGVFVTLYTVLLALTLplraldvvarehfeYTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYV
||||||.||.|.|..||..|  |                .  ... |.|..||||| |. ||| .|| |.|.|  
VHCsaGvgRTGtfialyllleqlek..............eggvdleeavkelreqR.pgavqtpsqyrflyeall
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2161-2424 5.9e-49 161.9 In-house 26-278 (305) alignment 
Range on Protein: 2161-2424
Range on HMM: 26-278/305.0
DEYTELNNMRPQLTTRVGQSHMAANRYRDILPCDETRVKLGAE------GYINANLVQlpvaPGENRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVT
 .| .| .   ..     . . |.||...| . |. |..| ..       ||||. |.      ..... |. ||||..| || |....|  ...|||.|
aqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvd....gykrkkkyivaqgPlkntvadfWrliveekvstivmlt

SEKEKGHIKCHRYWPVRKRKKVTARNFTIENLGVVKKSGFNVSTLQVHD-SASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSDAG-PMAV
  .| |. ||..||| .|..|.   .|..|     . |..    |..   . .  || |...|. |||||||| .|. .......|   | .| | |. |
klveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllV

HCSAGIGRSGVFVTLYTvllaltlplrALDVVAREHfeytSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKA
|||||.||.|||...            ||. . .|     .. | |....||..| . .||| .|| |.. |
hCsagvgRtGvfiavdi..........alerlkkEe....vvdvfevlkqlRskr.mkmvqtldqYvflhda
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2161-2428 1.1e-39 131.0 In-house 24-282 (290) alignment 
Range on Protein: 2161-2428
Range on HMM: 24-282/290.0
DEYTELNNMRPQLTTR--VGQSHMAANRYRDILPCDETRVKLG--------AEGYINANLVQlpvaPGENRHQAILCQGPLPETCADMWQMVWEQDTRVI
.... |..   . |.   ...|    ||...|.. |. |. |         .. ||||  ..      ....| |. |||...| .| |...|.... .|
nqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyik....gykekkqyiatqgpvsntlvdFWkliwqekvtii

VMVTSEKEKGHIKCHRYWPVRKRKKvtARNFTIENLGVVKKSGFNVSTLQVHDSAS-GASREVMHFQFIDWPDHG-VPSSAAQMVQMLREVALFQTSDAG
||.|...|.|. ||. ||| .. |.    .|.|. |   . ...   .|.|... | ||...|...|.  |...| |.  .. .... . .     .  .
vmltniieegkvkCqqYWpdsdtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgnt

PMAVHCSAGIGRSGVFVTLYTVLlaltlplralDVVAREhfeyTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYVTL
.. ||||...|||.||....| .          . .  |      | | ......| |. |  ||| .|| .... ..| 
sivvHCSdtvgrsavfcaaatti..........nkckte....gvidvfqvlksqRiqk.pgsvqtvqqyqgifqivlty
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2161-2424 3.5e-20 67.1 In-house 13-254 (267) alignment 
Range on Protein: 2161-2424
Range on HMM: 13-254/267.0
DEYTELNNMRPQLTTRVGQSHMAANRYRDILPCDETRVKLG--AEGYINANLVQlpvaPGENRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKe
.. ... . . .... ...   . ||. | || |.||| |    | ||||  |.      . ... |. |.||  | .| .... .|.  |||..|    
elikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyve....gyktknafivtqdplkntitdfltvihdqkvpvivlltkvf.

KGHIKchRYWPVRKRKKVTARNFTIENLGVVKKSGFNVSTLQVHDSASGAsREVMHFQFIDWPDHGVpsSAAQMVQMLREVALFQTSD-AGPMAVHCSAG
.. |.  ..|| .  .    ...|.|     ..  ... ||...     | ..|  . .  |           .  ..  .|  |  .   |. |.||.|
tdnir..lfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesa.hnvtlyyykkwnintn..nkpylkplfgilaknqlengnrPlvvacsdG

IGRSGVFVTLYTVLlaltlplraldvvAREHFEYTSiPVKEIVQKLREQRhPSVVQTSEQYLFVYKA
.|||| |..... |              |   | .|  . . ..|.|.|| ...|.| |.|..... 
vGrsGtflvidsql.............eraktegvs.difdflrkirsqr.iglvdtkeryiyihel
subfamily_eak_pd Subfamily eak 2161-2329 2.6e-13 44.1 In-house 30-198 (332) alignment 
Range on Protein: 2161-2329
Range on HMM: 30-198/332.0
DEYTELNNMRPQLTTRVGQSHMAANRY-RDILPCDETRVKLG-----AEGYINANLVQLPvapgENRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVT
.  ..|.. .. |. ....   | ||   .|.| |   |.|       .||||| |....    |  .. ||   .  .    .|||| || .  ||.. 
nivadlddyqrllsisetarleavnrnvvkivpydrylvrltssqlnrlGyinaslaefs....evGrkyiltGiasedkvfafwqmvleqkspaivqll

SEKEKGHIKCHRYWPVRKRKKVTARNFTIENLGVVKKSGFNVSTLQVHDSasGASREVMHFQFIDWPDHGVPSSA
 . |..  |  .|.| . |...    . .|    ||.. ...  |...      . .|.|...  | .  .|   
edvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskG..nethrvlhykvfGwtettlpkye
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2166-2427 1e-39 131.3 In-house 29-276 (287) alignment 
Range on Protein: 2166-2427
Range on HMM: 29-276/287.0
LNN---MRPQLTTRVGQSHMAANRYRDILPCDETRVKLGA--EGYINANLVQlpvaPGENRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKG
|..    . ..|  . ..    ||...||. |. || |    . ||||  ..      ..... |....|. .|  ..|......   .|||.. |||. 
leqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfid....gykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekend

HIKCHRYWPVRKRkkVTARNFTIENLGVVKKSGFNVSTLQVHDSA-SGASREVMHFQFIDWPDHG-VPSSAAQMVQMLREVALFQTSDAGPMAVHCSAGI
. .|..|||  |   |.  ...|| |   ...|. . .|.|. .  .|. ..|. .|. .|...| |.. .. .... . .   . .  ... ||||...
eevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtv

GRSGVFVTLYTvllalTLplralDVVAREhfeyTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYVT
|||..|.   |     |.     . . .|      | | ..... | |. |  ||| ||| |.... ..
Grsamfcaaat.....ti.....nkckte....GviDvfqvlksqriqk.pgsvqtveqykfindivle
subfamily_PTPN1_pd Subfamily PTPN1 2168-2426 1.6e-59 196.0 In-house 17-268 (290) alignment 
Range on Protein: 2168-2426
Range on HMM: 17-268/290.0
NMRPQLTTRVGQSHM--AANRYRDILPCDETRVKLGA--EGYINANLVQLPVApgenRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIK
.   ...||. . .   . |||||. | | .|.||      ||||.||.|. |    ... || |||||.|.. .|||||||... .||.    ||..||
keasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleea....krsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqik

CHRYWPVRKR-KKVTAR--NFTIENLGVVKKSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVA--LFQTSDAGPMAVHCSAGI
|..|||  .. |...    ..... .   .|| . |..|....  .  .||..|| .. ||| |||.| |.....| .|      .|| ||  .||||||
caqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGi

GRSGVFVTLYTVLLALTlplraldvvarEHFEYTSIPVKEIVQKLREQRHpSVVQTSEQYLFVYKAYV
|||| |. . |.|. .            .. ...|. .|. . .||..|.  ..|| .|  | | | .
GrsGtfclvdtclvlie...........kkddlssvdikkvllelrkyrl.Gliqtadqlrfsylail
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2168-2426 1.5e-44 147.4 In-house 39-281 (297) alignment 
Range on Protein: 2168-2426
Range on HMM: 39-281/297.0
NMRPQLTTRvGQSHMAANRYRDILPCDETRVKLGAEGYI-NANLVQLPVAPGeNRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHiKCHR
|..|| ...  .  .  .||..||| |  ||||   .   ... |     .| |.|. |  | | ..| ||.|.||..... .|||.. ..|. . || |
niqpqtvae.kkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkg.nkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcar

YWPVRKrkKVTARNFTIENLGVVKKSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPS--SAAQMVQMLREVA-LFQTSDAGPMAVHCSAGIGRSGV
||. .    .|  . ... | | ...||   .|.|  ... | | |  .||..|||. |.   ||....... ||   |..   ||. |||.||.|| ||
yWsdkg..vttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgv

FVTLytvllaltlplraLDVVArEHFEYTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYV
..|.             ..||| |  .  .. . ..|.|||..| | .||| ||| |||.| .
llti.............dsvva.eakrekevdifglvkklrqer.pylvqtkeqykfvyvavl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2168-2425 5.4e-43 141.9 In-house 31-272 (515) alignment 
Range on Protein: 2168-2425
Range on HMM: 31-272/515.0
NMRPQLTTRVgQSHMAANRYRDILPCDETRVKL------GAEGYINANLVqlPVApgENRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGH
|. ||  ..  .     |||..||| | .||||        . |.||  .  |    .| .  |  |||.. .  |.|..|.....  |.|||  ||   
niypqtvaqe.einfkknryknilPydsvrvklevindnPhsdyfnasyi..psf..dndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdk

IKCHRYWPVRKRKKVTARNFTIENLGVVKKSGFNVSTLQVHDSASgaSREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSDAGPMAVHCSAGIGRS
||| .||| .  . |   .. .| . .   .|    .|.|  .    || |  |.| .|||.|||  .  ......||   .   . |. .|||||.|| 
ikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrt

GVFVTLYtvllaltlplralDVVAREHfEYTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAY
||....              .|||. . .  .. | ..|...|..| | .||| ||| |.| | 
Gvvisid.............svvahak.ttrmvdvfnfvtnirqkr.pylvqtqeqyafiygav
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2169-2424 4.1e-25 83.3 In-house 23-265 (285) alignment 
Range on Protein: 2169-2424
Range on HMM: 23-265/285.0
MRPQLTTRVGQSHMAANRYRDILPCDETRVKLGA--EGYINANLVQLpvaPGENRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHR
| |. |    ..    ||| |.   .|||| |      || |. ...   ||...   |  ||||||| .|.|.|....    ..|. .  | |  ||  
mppnctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrm...pgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcal

YWPVRKRKKVTARNFTIE--NLGVVKKSG--FNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSDaGPMAVHCSAGIGRSG
|.| .  . |   .. |   .      .|  .|  |.   . ||     . | |   |||.  |  |  |... . |   .  .  |..||||||.||. 
yypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke.kpicvhcsagvgrta

VFVTLytvllaltlplralDVVAREHFEYTSIPVKEIVQKLREQRHPsVVQTSEQYLFVYKA
 || .              |  .   .|   | . .||...|  |    ||.  |.||.|  
tfvgi..............dyatirimenpniemldivremramrfq.avqshmqflflyvv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2170-2423 2.8e-21 70.4 In-house 41-284 (310) alignment 
Range on Protein: 2170-2423
Range on HMM: 41-284/310.0
RPQLTTRVGQSHMAANRYRDILPCDETRVKLGA-----EGYINANLVQLpvapGENRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKC
 . ||    . .|  ||| |..  |..||||       | || || |.        |   | .||||  |  |.|.|.... .  |...    |.|  ||
dssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvkt....nylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkc

HRYWPVRKRKKvTARNFTIENLGVVKkSGFNVSTL---------QVHD-SASGASREVMHFQFIDWPDHGVPSSAAQMVQMlRevaLFQTSDAGPMAVHC
  |||     . |     . ||.      |..  |          | .  |      |   .. .||| |||    . |   |   |.     ||  |||
vgywpslgvte.tygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq.r...llaqvrhgpcvvhc

SAGIGRSGVFVtlytvllaltlplrALDVVAREHFEYTSIPVKEIVQKLREQRHpSVVQTSEQYLFVYK
|||..| .| |              ||..      .   . ..|.. .|. .|   ..||  |||.. .
sagkdrlyvvv..............alklkidkldrglkvdaeevktellksra.iciqtelqyliidr
0045098 (Phosphotyrosine protein) phosphatases II 2172-2429 2.7e-67 222.4 In-house 24-272 (278) alignment 
Range on Protein: 2172-2429
Range on HMM: 24-272/278.0
QLTTRVGQSHMAANRYRDILPCDETRVKlgaeGYINANLVQLPvapgeNrHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPvR
. |. .  .... |||.||||.| .|||    .||||.... .     . .. |..|||||.|.|| |.|.||....||||.|...|.|..||..|||  
eitpalylgnldknRykdilpydhsrVk....dYINAsyidgy.....p.kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.e

kRKKVTARNFTIENLGVVKKSGFNVSTLQVHDS----ASGASREVMHFQFIDWPDHGVPSSA--AQMVQMLREVALFQT-------------SDAGPMAV
 .. .|  .||...| .   . . . || |..     ... ||.| |.... ||||||||.   ... ..|...  ..              .. ||..|
.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlV

HCSAGIGRSGVFVTLYTVLLALtlPlRALDvvarehfeytsipVKEIVQKLREQRhPS-VVQTSEQYLFVYKAYVTLL
|||||.||.|..| .|..|  |  . . .|             . |.|..||.|| |  .||. ||| |.|.. . ||
HCsaGvgRtGtlvaaylmlell..e.ggvd.............lleavkelrsqR.pglavqnleqyrflyefllell
subfamily_PTPN23_pd Subfamily PTPN23 2172-2427 1e-51 170.5 In-house 34-278 (288) alignment 
Range on Protein: 2172-2427
Range on HMM: 34-278/288.0
QLTTRVGQSHMAANRYRDILPCDETRVKLG--AEGYINANLVQLpVAPGENrhQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWP
. .. . . .   ||.||||| |..||||    . ||||  |.  ..||    . |  |.||..| .| |.||.|| ..||||..|..|.|. |..||||
krsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkd.lspgcP..dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwP

VRKRKKVTARNFTIENLGVVKKSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVAL----FQTSDAGPMAVHCSAGIGRSGVFV
 .| . |.  ....    | . . .   .|...   . | ..|.| |.  ||..|||.|  ...|.| ||       |     |. ||||||.||.||| 
edkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfa

TLYTVLLALTLPlRALDvvarehfeytsiPVKEIVQKLREQRHPSvVQTSEQYLFVYKAYVT
 .|... .|.     |              . ..|..|||||. . ||..||. |.|.| ..
lvyaavrelekg.ngll............diiqvvsrlreqRrfm.vqekeqlkfsyeavle
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2175-2425 5.4e-39 128.8 In-house 27-262 (283) alignment 
Range on Protein: 2175-2425
Range on HMM: 27-262/283.0
TRVGQSHMAANRYRDILPCDETRVKLGAE--GYINANLVQLpVAPGENRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRK
  . . .   ||...|.| |  ||.| .|   ||||  . .     .. .. | .|.|| .|  |.|.||....   |||.|  .|  .||| .||| | 
iasadenkrknrnqeivpadqwrvelksesrdyinavfipv.sksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG

RKkvTARNFTIENLGVVKKSGFNVSTLQVHDSASGASRE-VMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSDAGPMAVHCSAGIGRSGVFVTLYTVL
 .     .||.     . .  | .  | .. ..|  |   . |.|.||| . |  .    .|.. . ..| . |  ||. ||||.||||..||... . .
se..dyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasv

laltlplralDVVAREhfeyTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAY
          . .  |    . . | ..|. .|||| . .||| .|| .|... 
..........kdalte....svvdvfavvkimreqr.mmavqtldqyklvhelv
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2176-2425 2.1e-44 146.6 In-house 37-273 (315) alignment 
Range on Protein: 2176-2425
Range on HMM: 37-273/315.0
RVG--QSHMAANRYRDILPCDETRVKL------GAEGYINANLVqlPVApgENRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRY
||.  .  .  |||..||| |..||||        . ||||  .  .    .. .  |  ||||. .  |.|.||.....  |||||  .|   ||| .|
rvaretinfkknryknilPldsarvkleviddsPdsdyinasyi..ksv..dddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqy

WPVRKRKKVTARNFTIENLGVVKKSGFNVSTLqvHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSDAGPMAVHCSAGIGRSGVFVTL
|| || . |   .. .| | .   ..  .  |      | .|| |  ||| .|||.||.  .. ......||   . ..  .. ||||||.||.||....
wPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisi

YTVLlaltlplralDVVArehfEYTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAY
  |.          . ..    .  |. | ..|..||..| | .||| |.| |.| | 
devv..........aqik....rtrsvdvfnfvknlrakr.pylvqteeeyafiydav
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2176-2426 1.8e-29 97.3 In-house 38-233 (392) alignment 
Range on Protein: 2176-2426
Range on HMM: 38-233/392.0
RVGQ--SHMAANRYRDILPCDETRVKL------GAEGYINANLVQlpvaPGENRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGhikchry
.|.|    .  |||..||| |..||||        . |.||  ..      .| .  | .||| . .  |.|.||.....  |.|||  ||         
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyip....sfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.......

wpvrkrkkvtarnftienlgvvkksgfnvstlqvhdsASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSDAGPMAVHCSAGIGRSGVFVTL
                                          | |  |.| .|||..||  .. ......||     . . |. .|||||.||.|| ...
.....................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisi

YTVLlALTLPLRALDVvarehFeytsipvkEIVQKLREQRhPSVVQTSEQYLFVYKAYV
 .|. | .   | .||     |        ..| ..|..| | .||| ||| |.| | .
dsvv.ahakktrmvdv.....f........nfvtnirrkr.pymvqtkeqyafiygavl
0040439 (Phosphotyrosine protein) phosphatases II 2177-2426 5.7e-67 221.2 In-house 7-243 (249) alignment 
Range on Protein: 2177-2426
Range on HMM: 7-243/249.0
VGQSHMAANRYRDILPCDETRVKLGA------EGYINANLVQLPVAPGEnrhqAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPV
  . ..  |||.||||.| .||||.        .||||... ..  . .     |..|||||||..| |.|.||.. .||||.||..|.|..||..||| 
llpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr....fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

rkRKKVTARNFTIENLGVVKKSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTS--DAGPMAVHCSAGIGRSGVFVTLY
  .. ..  .||...| | .|... | ||.....  | ||.|.|.|..||||||||.| .........|  ....  . ||..||||||.||.|.|...|
..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

TVLLALTLplraldvvarehfeYTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYV
..|  |                .  ....|.|..||.|| | .||. ||| |.|.|  
lmleqlek..............elgvdleeavkllrsqR.pgavqnpeqyrflyeall
subfamily_CG7180_pd Subfamily CG7180 2177-2423 1.9e-27 90.7 In-house 38-284 (296) alignment 
Range on Protein: 2177-2423
Range on HMM: 38-284/296.0
VGQSHMAANRYRDILPCDETRVKLG------AEGYINANLVQLPVAPgenrHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHiKCHRYWPV
...  .  ||. ...| | .|| |        . ||||  |.  . .    .. |  ..|  ||  . |..|.....  .|..| . .  . ... ||| 
lrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkk....keyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpn

RKrkKVTARNFTIENLGVVKKSGFNVSTLQVHDS----------ASGASREVMHFQFIDWPD-HGVPSSAAQMVQMLREVALFQTSD-----AGPMAVHC
.   |   ... .| . . . . ..  |...              .   | |..||.  |.  . ||.|.. .....| | |..         ||. |..
ks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvs

SAGIGRSGVFVTLYTvllaltlplrALDVVAREHfeytSIPVKEIVQKLREQRhPSVVQTSEQYLFVYK
| | .||||....            .|. | .|.     . | | |..||..| | .|.. |.| ..| 
sdGasRsGvylaida..........nlelvekee....evdvFeavktlrrsR.pqLvenveeYkyiYd
subfamily_PTPN12_pd Subfamily PTPN12 2178-2429 1.9e-61 202.5 In-house 37-277 (290) alignment 
Range on Protein: 2178-2429
Range on HMM: 37-277/290.0
GQSHMAANRYRDILPCDETRVKLG------AEGYINANLVQLPvapgENRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVR
 ..... |||.|||| |..||.|        ..|||||... .    |.... |  |||||.|  | |.|.||......||.  | | |..||.|||| .
keenvkknrykDilPydksrvelskieeeegsdYinanfikgv....egkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpee

KRKKVTARNFTIENLGVVKKS-GFNVSTLQVHDSasGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSDAGPMAVHCSAGIGRSGVFVTLYTV
. ....  .|....    . . .| . ||.|. .  ..||.|  |.. .|||||||||| ........|  .|.|.. |..||||||.|| |. ...  |
geeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyv

LLALTLplralDVVArehfeyTSIPVKEIVQKLREQRHpSVVQTSEQYLFVYKAYVTLL
  .|       . ..       .. | ..|..||.||. ..||| ||| .|||| . |.
rellka.....ekip......eeldvfdlvlelrkqra.alvqtkeqyelvykavaelv
subfamily_PTPRN_pd Subfamily PTPRN 2178-2426 1.1e-35 117.8 In-house 53-289 (297) alignment 
Range on Protein: 2178-2426
Range on HMM: 53-289/297.0
GQSHMAANRYRDILPCDETRVKLGAEG------YINANLVqlpvAPGENRHQA-ILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPV
 .  .  ||....|| |..|||| .|       ||||  .       . |. | | .||||..| ||.||||||| . |||..|. .|.|  .|.|||| 
aeknvkknrskavlpydhsrvklkeeasaeksdyinasai....ldhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpd

RKRKKVTARNFTIENlGVVKKSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSDAGPMAVHCSAGIGRSGVFVTLYTV
   .   . .  .     .    . | .. . .  .  .| |  | |. ||..|||.||  .... | |       . |. ||||.| ||.||.. .  |
eGsevyhiyevhlvs.ehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlv

LLALTLPLRALDVVArehfeyTsipvkeiVQKLREQRhPSVVQTSEQYLFVYKAYV
|  |.  .. .|..|      |       ...||.|| | .|.| .|. |...| .
lnrllkGvkeidiaa......t.......lehlrdqr.pglvktkdqfefaltava
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2178-2427 1.4e-33 111.1 In-house 44-342 (350) alignment 
Range on Protein: 2178-2427
Range on HMM: 44-342/350.0
GQSHMAANRYRDILPCDETRVKLG--------------AEGYINANLVQLPVAPGE--NRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGH
|   .| |||..||| . .||||               .. ||||| ..|..   |    .. |  |.|||.|  |..... . . .||...||. | . 
GvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnl

IKCHRYWPVRKRKKVT------------ARNFTIENLGVVKKSGFNVSTLQVHDS-----------ASGASREVMHFQFIDWPDHGVPSSAAQMVQMLR-
 ||.|||.  . ...|            ... ..   .| |..  |    ...|            |.    .|...|.  |.| ..     ...|.|  
ekcyrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalev

---------EVALFQTSDAGPMAVHCSAGIGRSGVFVTLYTVLL-ALTLPLRALDVVAREHFEYTSIPVKEIVQKLREQRHpSVVQTSEQYLFVYKAYVT
             .... . |. ||||||.|| |..|||  .|   . |     . .  .    |  ... ||..||.||  |.||. .|..|.|.|   
kndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqri.smvqnldqfifiYeallf
subfamily_CG42327_pd Subfamily CG42327 2178-2339 2.4e-24 80.6 In-house 25-190 (319) alignment 
Range on Protein: 2178-2339
Range on HMM: 25-190/319.0
GQSHMAANRYRDILPCDETRVKLGA------EGYINANLVQlpvAPGENRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVR
  .    .|. ...|  |||| |        . |..|. |.    . . . . | .| .| .. .|.|..|||| .|||| .|.  |.|  .| .|.| .
PvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvr...GyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtk

KRKKVTA--RNFTIENLGVVKKSGFNVSTLQVHDSASGASREVMHFQFiDWPDHGVPSSAAQMVQMLREV
.  . |    .. .   |   |  . .||| ..      |||. |. . .|.. .||.. | .. || ||
etldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllev
0037934 (Phosphotyrosine protein) phosphatases II 2179-2428 1.7e-66 219.5 In-house 8-241 (243) alignment 
Range on Protein: 2179-2428
Range on HMM: 8-241/243.0
QSHMAANRYRDILPCDETRVKLGAEGYINANLVQLPvaPgenrhQAILCQGPLPETCAD----MWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPvrkrK
. ..  |||.||||.| .||||. ..||||||.. .  |     . |..|||||||..|     |.|.||....||||.|...|.|..||..|||     
penlsknrysdilpydhsrvklegsdyinanliyvt..p.....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp....g

-KvTARNFTIENLGVVKKSGFNVSTLQVHDSA-SGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALF--------QTSDAGPMAVHCSAGIGRSGVF
 . |  .||...|..  .... | ||..     .. .|.|.|.... |||||||.| ......|.||  |        . .. ||..||||||.||.|..
ev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtl

VTLYTVLLALtlplraldvvarehfeytSIPVKEIVQKLREQRHPSVVQTSEQYLFVYKAYVTL
...|..|| |                  .... |.|..|||||.  .||| .|| |.|.|.  |
iaaylmllll..................gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2179-2335 4.8e-36 119.1 In-house 31-189 (297) alignment 
Range on Protein: 2179-2335
Range on HMM: 31-189/297.0
QSHMAANRYRDILPCDETRVKLG----AEGYINANLVQLPVAPgeNRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRK
.| .  |||||||  |.|||||      . ||||. | .|  .  .  . || |||| .|  | |..|.||| ||||||.  .| |  ||  |||  . .
nsslrknryrdilatddtrvkllrviterdyinadyvvfpdee..adlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe

KVTARNFTIENLGVVKKSgFNVST---LQVHDSasGASREVMHFQFIDWPDHGVPSSAAQMVQM
. .| .. .| |  .    |.      ||.       || | | ||. ||||||||   ..|..
rlkagdvvveflsstsde.fdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2179-2424 3.5e-31 103.3 In-house 41-266 (288) alignment 
Range on Protein: 2179-2424
Range on HMM: 41-266/288.0
QSHMAANRYRDILPCDETRVKLG--AEGYINANLVQlpvaPGENRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRKKV
 .  . .||...  || |||||   .. ||.||.|      ...... | .| ||  |   .|.|. |.| . |||..   |||. |   |.|... .|.
ianptrdryenlprcditrvklsddpdfyiaanvvs....sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

TARNFtienLGVVKKSG------FNVSTlqVHDSASGASRE-VMHFQFIDWPDHGVPSSAAQMVQMLREValfqTSDAGPMAVHCSAGIGRSGvfvTLYT
  . .      ||||.        .||.  .. |  |  .  | .  . .|.|.||| .    ...|  .     |   |. ||.|||.||.|   ||  
rigrl....ctvvkkkradidklvkvsl..lriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtg...tlil

VLLALtlplralDVVAREHFeytsIPVKEIVQKLREQRHPSvVQTSEQYLFVYKA
.|.||       ...  . |    . ......||||.|  . .||  |||.|.. 
ilial.......eslrlddf....lgirsllaklreerfka.iqtemqylyvhrc
0042113 (Phosphotyrosine protein) phosphatases II 2180-2427 1.8e-65 216.1 In-house 8-241 (245) alignment 
Range on Protein: 2180-2427
Range on HMM: 8-241/245.0
SHMAANRYRDILPCDETRVKLGAEG------YINANLVQLPVAPGEnrhqAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVrkR
 ..  |||.||||.| |||||  .|      ||||..| ..  ..      |..|||||||..| |.|.||.. ..|||.|.| |.|..||..|||   .
enkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk....fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..g

KKVTARNFTIENLGVVKKSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQT-SDAGPMAVHCSAGIGRSGVFVTLYTVLL
 ..|  .||...|.. ..... | ||.|..  .. ||||.|.....|||||||.. ......|..|  ..  .. ||..||||||.||.|.|...|..| 
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

ALTL----PlraldvvarehfeytsipVKEIVQKLREQRhPSVVQTSEQYLFVYKAYVT
 |      .                  . |.|..||.|| | .||| .|| |.|.|   
qlekelgvs..................leeavkelrsqR.pgavqtpsqyrflyealle
subfamily_PTPRG_pd Subfamily PTPRG 2180-2428 3e-46 152.8 In-house 46-286 (563) alignment 
Range on Protein: 2180-2428
Range on HMM: 46-286/563.0
SHMAANRYRDILPCDETRVKL----GAEG---YINANLVQlpvapGENR-HQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVr
.    ||| .|.. |..||||    | ..   ||||| ..     | .. .. |  ||||..|. | |.|.||| . .|||.|  .|.|. ||..|||  
enkrKnRylnivaydrsRvklsplpgkkkklDYinAnyid.....GyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.

kRKKVTARNFTIENLGVVKKSGFNVSTLQVHD------SASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSDAGPMAVHCSAGIGRSGVFV
  . .|  ....      ...  .| ||....      .     ..|..... .|||||||....  ... .  .  . ..|||. ||||||.||.|...
.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyi

TLYTVLLALTlplraldvvarehfEYTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYVTL
 | |.|  .               .  .. | ......| || . .||| |||.|...| . .
vldtllkqiq..............qenavnvfgflkhiraqR.nflvqteEqYiflhdallea
subfamily_ptpA1_pd Subfamily ptpA1 2180-2384 3.3e-33 110.0 In-house 45-266 (418) alignment 
Range on Protein: 2180-2384
Range on HMM: 45-266/418.0
SH-MAANRYRDILPCDETRVKLGA------EGYINANLVQlpvapGENRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRK
 |  . ||| .||| . |||.|          ||||| ..     |   .| |  |||||.| ||.|.||||.  |.|||.. | |. .||| |||| . 
khntsknrytnilpvnhtrvqlkkiqdkegsdyinanyid.....gaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqi

RKK---------VTARNFTIENLGVVKKSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVAL-----FQTSDA-GPMAVHCSAG
  .              ...| . |..    .. | ... .  | .|.. ..|.  |||| .|  .  . |.|. ..        .||   |. ||||||
ggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsag

IGRSGVFVTLYTVLLALTLPLRALDVV
.||.| |.|   ..  |   .. ||  
vgrtgtfctavimmkkldhyfkqldat
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2181-2427 9.6e-55 180.5 In-house 20-262 (270) alignment 
Range on Protein: 2181-2427
Range on HMM: 20-262/270.0
HMAANRYRDILPCDETRVKLGA------EGYINANLVQlpvAPGENRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRK
. . |||.||||  .|||.|          ||||| |.      ..... |  .|||| |  . |.|.||. .. |||.|  .|||. || |||| .. .
gkklnRyadiLPsPatRvrleeleedsataYinAnyvr...GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

KVTARNFTIENL--GVVKKSGFNVSTLQVHdsASGASREVMHFQFIDWPDHGVPSSAA------QMVQMLREVALF--QTSDAGPMAVHCSAGIGRSGVF
||. .. .|. |    .|..|. .  |...   .| .|...||.. .|||||||...       |...|||.|  .  ....|.|. ||||||.||.|..
kvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtl

VTLYTVLlaltlplRALDvvarehfEYTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYVT
..| ...       |.|.       | ... | .|...||..| . .||..||| |.||| |.
ialDiav.......rlLe.......etkkvdvlaiieelRkdR.malvqhpeqyeflykavve
0049772 (Phosphotyrosine protein) phosphatases II 2181-2429 1.3e-35 119.1 In-house 46-280 (314) alignment 
Range on Protein: 2181-2429
Range on HMM: 46-280/314.0
HMAANRYRDILPCDeTRVKLG-----AEGYINANLVQLPvapgenrHQAILCQGPLPETCADM----------WQMV--WEQDTRVIVM-----------
..  ||| |||| | .||.|.       .||||. |  .        . | .||||..|. |           |.||  .....|.|||           
nrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.......lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------VTSEKEKGhikchRYWPVRKRKKVTarnftienlgvvkksgfnvstlQVHDSASGASREVMHFQFIDWPDHGVPsSAAQMVQMLREVALF
           ..  ..|      .....  .                         .......  .|.....  |..||...| . ... ..|. .  .
rLdaAlgKtpllildgng.....neptaadlellk......................eelydpelferlgikylripvpDgsap.lledfdeflefieea

qtSDAGPMAVHCSAGIGRSGVFVTLYTVLLALTlplraldvvarehfeytsIPVKEIVQKLREQRH----PSVVQTSEQYLFVYKAYVTLL
  .. || .|||.||.||.|.||... ....|                   ....|... .|..|.    |. ... |||.|...|.  .|
..dkggpvlvHCkaGkgRtgtfvvaaylmkllg..................vsleealedvrlkRpinpnpgfieqleqyefilealleyl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2181-2425 6.2e-32 105.4 In-house 55-285 (305) alignment 
Range on Protein: 2181-2425
Range on HMM: 55-285/305.0
HMAANRYRDILPCDETRVKLGA---EGYINANLVQLPVAPgENRhqAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRKKVT
 .. |||.|.   |.. |||       || || |  |. | |.|   | .|||| .|  ..| || ..    |||.    | |..|| .|||. . .|..
aitknryqdvpcqdqsavkldkpspsdyihanyvgcpmip.ekr..ficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

ARN-FTIENLGVVK----KSGFNVSTLQVHDSaSGASREVMHFQFIDWPDHGVPSSAAQMVQMLREValfQTSdAGPMAVHCSAGIGRSGVFVTLYTVLl
 ..   .||.   |     .  ....|..  |  . .  | |.|. .||| |||      ...|  .   . |   |. |||||||||.|  |..  .| 
lksgivvenvsgskpmerdaeiqitllnltys.gdqkmsvrhlqwtewpdrgvppckltslellsai...rgs.kvpivvhcsagigrtgtivaieyil.

altlplralDVVAREHfeyTSIPVKEIVQKLREQRHPSvVQTSEQYLFVYKAY
         . .| ..      |. |.|. ||.||  | .|.  ||||...  
.........ekiaenk...pcppmpelvkalrdqrafs.iqndvqylfihrvm
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2182-2426 1.5e-40 134.1 In-house 50-276 (315) alignment 
Range on Protein: 2182-2426
Range on HMM: 50-276/315.0
MAANRYRDILPCDETRVKL-GAEGYINANLVQLPVAPGENRHQ-AILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRkrkKVTAR
   ||| .|.. |..||.|   |   ... |     .| |...  | .|||....  |.|..|.|.|   |||.|.  |. . |. .||| .   ||.  
kqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyG

NFTIENLGVVKKSGFNVSTLQVHdsASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSDAGPMAVHCSAGIGRSGVFVTLYTVLlaltlplr
..|.      ... . | || |        |||. ...  ||| ||| ..  .... | |  ..|...|.. ||||||.||.| |.|| .||        
kitvtrkseevnteytvrtlsvv..fgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavl........

alDVVAREhfeyTSIPVKEIVQKLREQRHpSVVQTSEQYLFVYKAYV
  | .  |      | | ......|..|   .||. ||| |.|.| .
..dqaeae....naidvynfitgvrqnri.kmvqvaeqyqfiydall
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2182-2428 1.2e-39 130.8 In-house 39-276 (287) alignment 
Range on Protein: 2182-2428
Range on HMM: 39-276/287.0
MAANRYRDILPCDETRVKLGAEG-----YINANLVqlpvAPGENRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRkRKKV
.  ||| |.|| |.||| | |||     ||||| |    |  .. .. | .|||.. |  |.|..|.|. . .....| | |..  ||..||| | .. .
vkknryadvlPiddtrvllsaegelGsdyinanyv....asytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPm

TARNFTIENLGVVKK-SGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREV-----ALFQTSDAGPMAVHCSAGIGRSGVFVTLYTV
    ...  |   .|   . | .|.. |  .  .| |  .....|||.... .|  ....  .|     .  ..|..||. ||...||||||........
rvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl

LlALTLPLRALDVVArehfeytsipvkeIVQKLREQRHpSVVQTSEQYLFVYKAYVTL
.    . |  .|| |             .| .|||.|  ..||.  |. ..|.| || 
v.srledlGrvdvaa.............vvirlreyra.alvqavvqlrllyealvty
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2182-2424 3.4e-37 122.8 In-house 49-282 (305) alignment 
Range on Protein: 2182-2424
Range on HMM: 49-282/305.0
MAANRYRDILPCDETRVKLGA---EGYINANLVQLPVapgeNRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKR-----
   |||.|.   |. |||| .     || || |  |     | .. | .| || .||||.| | ...    | |.   .|||  ||. |.. ...     
agknrykdvgcldnnrvklegpwpheyihanyvstpt....npkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

----KKVTARNFTIENLGVVKKSGFNVS-TLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREValfqTSDAGPMAVHCSAGIGRSGVFVTLY
    .|.. .  . ..|  .|..  .|. |  | . . . .| | |. .||||| |||..   ....| .      .  ||..|||||||||.|  | | 
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka....rpskgpivvhcsagigrtgsvvmle

TVLLALtlplraldvVAREHFEYTsipvKEIVQKLREQRHPSvVQTSEQYLFVYKA
 .|  |         .| .  | |    . |.||.||||  | .|| .|||||.. 
yildql.........lagqiiedt....dkilqkireqrnns.iqtdaqylfvhqv
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2182-2375 3.4e-35 116.1 In-house 57-244 (290) alignment 
Range on Protein: 2182-2375
Range on HMM: 57-244/290.0
MAANRYRDILPCDETRVKL--GAEG-YINANLVQlpvapGENrHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRKKVTA
.  |||.|.   | ||| |  | .| |. || |.     | .    || ||.| .|  |.|.|| .... .|||.    |.|. ||..|.| .. . .| 
fkknrykdvvcndktrvilkdGydGdyvhanyvk.....Glk.amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltf

RNFTIEN-LGVVKKSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVAlfqtSDAGPMAVHCSAGIGRSGVFVTLYTVLLALT
 ..|.   .   | .     || | |  || .  . |.. . |||. |. |.  ....|| .       .||..|||||||||.| ||.. . |  |.
GeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilr....kasGpvvvhcsaGiGrtGtfvaievglqill
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2182-2425 1.3e-28 94.8 In-house 8-236 (239) alignment 
Range on Protein: 2182-2425
Range on HMM: 8-236/239.0
MAANRYRDILPCDETRVKLG------AEGYINANLVQlpVAPGENrHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRKK
 | ||| .|.  | .|| |          ||||. ..     |   .  |  || .  .. |.|.|.|..   ||||.|   |  . |||.|||    | 
kaknryanivtydhsrvvleklsndphsdyinasylr..dydgsp.kayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

VTARnFTIENLGVVkkSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSDAGPMAVHCSAGIGRSGVFVTLYTVLlalt
.  |  |. .  |.  . . . |. . .      | | ...|  |||.|||  |. .. . |...      | |  .|||||.||.| |. . ..|    
cnlr.vtlrktevf..adyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml....

lplraldvvaREHFEYTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAY
          |.  .  .. . . |. .||.| | .|||||||.|.. | 
..........rqakkqktvdifnyvkairedr.phmvqtseqyvfihlav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2182-2424 1.5e-28 94.6 In-house 9-236 (239) alignment 
Range on Protein: 2182-2424
Range on HMM: 9-236/239.0
MAANRYRDILPCDETRVKLG------AEGYINANLVQlpVAPGENrHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRKK
 | ||| .|.  | .|| |          ||||. ..     |   .  |  || .  .. |.|.|.|..   ||||.|   |  . |||.|||    | 
kaknryanivtydhsrvvleklsndphsdyinasylr..dydgsp.kayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

VTARnFTIENLGVVkkSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSDAGPMAVHCSAGIGRSGVFVTLYTVLlalt
.  |  |. .  |.  . . . |. . .      | | ...|  |||.|||  |. .. . |...      | |  .|||||.||.| |. . ..|    
cnlr.vtlrktevf..adyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml....

lplraldvvaREHFEYTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKA
          |.  .  .. . . |. .||.| | .|||||||.|.. |
..........rqakkqktvdifnyvkairedr.phmvqtseqyvfihla
Y_phosphatase Protein-tyrosine phosphatase 2183-2425 1.4e-67 222.9 Pfam-A 3-233 (235) alignment 
Range on Protein: 2183-2425
Range on HMM: 3-233/235.0
AANRYRDILPCDETRVKL----GAEGYINANLVQLPVApgenRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRKKVTA
  |||.||||.|.|||||    |.. ||||| |..        .. |..||||..|..| |.|||.....||||.||..|||  ||..||| ......| 
kknRykdilpydktrvklkgsegpsdYInAnyvkgyke....kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

RNFTIENL-GVV-KKSGFNVSTLQVHDSASG-ASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSDAGPMAVHCSAGIGRSGVFVTLYTVLLALT
 ....|.   .  .........|.......  ..|||..... .|||||||.|. ......|.|   .... ||. ||||||.||.|.||.| ..|  |.
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

LplraldvvaR-EhfeytsIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAY
          . |      . |..||..||.|| |..||. ||| |.||| 
a.........eee......vdvlqivkelRkqR.pgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 2183-2425 1.4e-67 222.9 In-house 3-233 (235) alignment 
Range on Protein: 2183-2425
Range on HMM: 3-233/235.0
AANRYRDILPCDETRVKL----GAEGYINANLVQLPVApgenRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRKKVTA
  |||.||||.|.|||||    |.. ||||| |..        .. |..||||..|..| |.|||.....||||.||..|||  ||..||| ......| 
kknRykdilpydktrvklkgsegpsdYInAnyvkgyke....kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

RNFTIENL-GVV-KKSGFNVSTLQVHDSASG-ASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSDAGPMAVHCSAGIGRSGVFVTLYTVLLALT
 ....|.   .  .........|.......  ..|||..... .|||||||.|. ......|.|   .... ||. ||||||.||.|.||.| ..|  |.
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

LplraldvvaR-EhfeytsIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAY
          . |      . |..||..||.|| |..||. ||| |.||| 
a.........eee......vdvlqivkelRkqR.pgmvqsleqYiflykai
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2183-2427 3.8e-44 145.8 In-house 11-240 (250) alignment 
Range on Protein: 2183-2427
Range on HMM: 11-240/250.0
AANRYRDILPCDETRVKLGAEG------YINANLVQlpVApgENRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIkCHRYWPVRKRKKV
  ||| ||.. |..|| |  |       ||||  ..  .   ..|.  |  ||||..|  |.|.||.|... .|||.|. ||...  .|.|||| | .| 
eknryadiialdssrvvLekekgdkesdyinasflh..gy..derkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaeky

TarNFTIENLGVVKKSGFNVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTS-DAGPMAVHCSAGIGRSGVFVTLYTVLlalt
   . |.. |   ... . . .|..       .| | ...|. ||| |||  |  ....|..|   |   ...|. |.||||.|||| |.....||    
G..dvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl....

lplraldvvAREHFEyTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYVT
          | . |   . | .....||..| | .|.. ||| |||..   
.........erlkke.kvvdvfkvikvlrkdr.phavesleqyvfvyeiilk
0041856 (Phosphotyrosine protein) phosphatases II 2183-2426 3.7e-41 136.1 In-house 3-168 (182) alignment 
Range on Protein: 2183-2426
Range on HMM: 3-168/182.0
AANRYRDILPCDETRvklgAEGYINANLVQLPVAPGEnrhqAILCQGPLPETCADMWQMVWEQDTRVIVMVTsekekghikCHRYWPvrkrkkvtarnft
  |||.||||.| .|       ||||||.  .  . .     |..||||..|.||...|..|.. ..||..|         ...|||             
dknrysdilpydhsr....dldyInanlylgslpatr....fiatqgpllstvadflrmlkelgittivnlt.........eelywp.............

ienlgvvkksgfnvstlqvhdsaSGASREVMHFQFIDWPDHGVPSsAAQMVQMLREVALfqtsDAGPMAVHCSAGIGRSGVFVTLYTVLLAltlplrald
                       .   |........ |||||||.   .......||      . || .||||||.||.|..| .| ..           
.......................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.........

vvarehfeytSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYV
          .... |.|. .|..| | .|.| .|| |.. |. 
..........gvsleeavklvrsrR.pgmvitpnqyfflqlall
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2183-2427 3.6e-39 129.9 In-house 63-289 (319) alignment 
Range on Protein: 2183-2427
Range on HMM: 63-289/319.0
AANRYRDILPCDETRVKL----GAEG--YINANLVQlpvaPGENRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTsekekgHIKCHRYWPVRKRKKv
  ||. .||. |...|||    | |.  ||||  |.       .. . | .||||..| ||.|.|.||...  ||..|      . || .||| .  .| 
dknriinilafdknvvklerliGeefsdyinasfvt....GyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik.

tARNFTIENLGVVKKSGFNVSTLQVHD-SASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTS--DAGPMAVHCSAGIGRSGVFVTLYTVlla
   .| ..   | . . . |  ... . .     |..  | |  |||.||| .......... |  ...   .  .. ||||||.||.||...| ..   
.eerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvl...

ltlplraLDVVAREhfeyTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYVT
       || . .|      . | ..|. ||.|| . .||   || |.| | . 
.......ldrmkee....kqvdvynfvrdlrqqr.ntlvqdlvqykfiysalle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2183-2424 1e-34 114.8 In-house 5-234 (237) alignment 
Range on Protein: 2183-2424
Range on HMM: 5-234/237.0
AANRYRDILPCDETRVKLGAEG----YINANLVQLpvAPGEnRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRKKvTA
. ||| .|   | .|| |   |    ||||. ..     |   .. | .||||  .| |.|||||..   ||||.|   |. ..|||.|||  .. . . 
iknrygnivaydhsrvvlkgagsgsdyinatylkg..fdgt.pkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa.ay

RNFTIENLGVVKKSGFNVSTLQVHDSAS-GASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQ--TSDAGPMAVHCSAGIGRSGVFVTLytvllalt
  .|.      . | . | .| .    .    | .  .||  |||.|||  .| .... ...       |..||  .|||||.||.|.|. .        
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvi........

lplralDVVAREHFEYTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKA
      | . |.  |   . . . |. . |.| | ..|| .||.|....
......damlrqakekkvvdiynyvysieedr.pyiiqtkdqyvfihqt
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2183-2420 6e-33 108.9 In-house 52-272 (301) alignment 
Range on Protein: 2183-2420
Range on HMM: 52-272/301.0
AANRYRDIlPCD-ETRVKLGAEG---YINANLVQLPvapgENRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRKKVTA
  .||  . ||. .| |.. ..|    | || .. .     . |. |  ||||..|. |.| |.   |   |||.. . || . ||. | ||. ..|.  
dkhryptv.PckPstavevivdGkrvPihanwipts....GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi

RNFTI--ENLGVVKKSGFNVSTLQVHDSASG-ASREVMHFQFIDWPDHGVPSSAAQMVQMLRevaLFQTSDaGPMAVHCSAGIGRSGVFVTlyTvllalt
  |.|  .|  .. .   .  ||.|.||.   |.| |.|.|. .|.|.||| | |.. ...    | . |.  |. ||||||||||  |..  |      
grfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlme...lvkkse.kPivvhcsaGiGrsvafig..t......

lplralDVVAREHFEYTSIPVKEIVQKLREQRHPSvVQTSEQYLF
      ...|||      | ..| ...|||.|  . ||| .|  .
......eylareveadptieltealkhlrehrwng.vqtnsqlyw
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2183-2426 6.2e-30 98.8 In-house 39-266 (281) alignment 
Range on Protein: 2183-2426
Range on HMM: 39-266/281.0
AANRYRDILPCDETRVKLGA-------EGYINANLVQLPVApgenRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRKK
  ||| .|   | .||.|           || || .. |.     ..  || |||  || ||.|.|.|...|  |||.    |  . ||  |.|   .  
kknrylnipcldisrvqlkvkmpnknstdyihanyirspfl....krgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcc

VTARNFTIENL-GVVKKSgfnVSTLQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVAlfqtSDAGPMAVHCSAGIGRSGvfvTLYTVLLAL
.   .....     |.||   . | ..  |  | .| . |. . .|||  || |.  |...||..     . . |  .|||||.||||   || .| .||
lqfdklsvsyedstvnks...lvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir....arstppvihcsagvgrsg...tlmaveial

tlplRALdvvaREHFeyTSIPVKEIVQKLREQRHPSVVQTSEQYLFVYKAYV
    ...    . ||  |   .|.|| .||   . . ||| .||....|  .
....qsi....hshf..tlpdikqivshlrvtgraasvqtlqqymliwkvll
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2184-2427 7.9e-39 128.8 In-house 28-253 (284) alignment 
Range on Protein: 2184-2427
Range on HMM: 28-253/284.0
ANRYRDILPCDETRVKL----GAEG--YINANLVQlpvaPGENRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTsekekgHIKCHRYWPVRKRKKvt
 ||. .||. |...|||    | |.  ||||  ..       .... | .||||..| ||.|.|.||...  ||..|      . || .||| .  .|  
knrighilafdknvvklerliGeefsdyinasfit....GyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik..

ARNFTIENLGVVKKSGFNVSTLQVHD-SASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTS--DAGPMAVHCSAGIGRSGVFVTLYTVllal
  .| ..   | . . . |  ... . .     |..  | |  |||.||| .......... |  ...   .  .. ||||||.||.||...| ..    
eerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvl....

tlplraLDVVAREhfeyTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYVT
      || . .|      . | ..|..||.|| ...||   || |.| | . 
......ldrmkee....kqvdvynfvrdlrqqr.ntlvqdlvqykfiysalle
subfamily_egg_pd Subfamily egg 2194-2425 2.5e-21 70.7 In-house 53-266 (307) alignment 
Range on Protein: 2194-2425
Range on HMM: 53-266/307.0
DETRVKLGA-EG-----YINANLVQlpvaPGENRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKghIKCHRYWPVRKRKKVTA--RNFTIEN
| .||||   .|     .| || |.     .    . ||.| || .|  |.|.||.... . |||.|| ||    .|. |||  . . .     .. |||
dssrvklelrrGqylddfihanrvk....Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrien

LGVVKKSG--FNVSTLQVhdsaSGASREVMHFQFIDWpDHGVPSSAAQMVQMLREVAlfQTSDagPMAVHCSAGIGRSGVFVTLYTVLLALtlpLRAlDV
|.| .|.   |.|. |..     |. .| .. .   . |    |     ...|| .   . |   |. |..  |. .....|.. . || |   ||   .
lkvdskadplfrvtklkl....vGgddeerflehwqg.dvnnssdvysplrvlrklr..nlsk..pvvvqdilGvskaatlvaieiallsl...lrG.pi

varehfeyTSIPVKEIVQKLREQRHPSvVQTSEQYLFVYKAY
        |  .|.. |. || .|. | |..  .|||||.  
........tkslvlravvflrlrrrls.vesvllylfvyrlv
0051429 (Phosphotyrosine protein) phosphatases II 2201-2429 6.3e-44 146.0 In-house 2-225 (272) alignment 
Range on Protein: 2201-2429
Range on HMM: 2-225/272.0
GAEGYINANLVQLPvapgE---NRHQAILCQGPLPETCADMWQMvWEQDTRVIVMVTSEKEKGHIKCHRYWP----------VRKRKKVTARNFTIENLG
  .|||||. |  .         ..  ....|||| |.|| |.. .|.. ..||...|| |.|. ||.||||           .    ..  .... .| 
plsgyiNardvggy....grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtlls

VVKKSGFNVSTLQVHDS-ASGASREVMHFQFIDWPDHGVPSSAaqMVQMLREVALfqtsdAGPMAVHCSAGIGRSGVFVTLYTVLLALTLPlraldvVAR
.. .. . . .|...     |..|||||....||||||||..|  ....|....       ||. ||||||..|.|..| |. .|| ..|       .  
eellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsle......tiv

EHFEYTSIPVKEIVQKLREQRhPSVVQTSEQYLFVYKAYVTLL
. . .|.. . |.|..||.|| | .||| |||||.|.|.. ||
ddYlltnlyleeaveelraqr.pgavqteeqylflyeallell
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2202-2422 2.9e-13 44.6 In-house 45-252 (290) alignment 
Range on Protein: 2202-2422
Range on HMM: 45-252/290.0
AEGYINANLVQLPvapgeNRHQAILCQGPLPET-------CADMWQMVWEQDTRVIVMVTSEKEKGHI----KCHRYWPVRKRKKVTARNFTIENLGVVK
...|| || |. |     |  . || | |. ..         . | |. .   . .||.   .|| .      | .| | .  ....  ..|..    .|
nddyiHAnrvtcp.....nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskek

KSGFNVSTLQVHDSaSGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVAlfqtSDAGPMAVHCSAGIGRSGVFVTLytvLLaltlplrALDVVAREHfe
. .... .| |.    .    | | .. .| .  |. .   ...... |         |. |||  || || .. ..    |       .   .|  .  
eddvetRelvvkfd.deeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaai...il.......gyQkiaets..

yTSIPVKEIVQKLREQRHPSVVQTSEqYLFVY
  |. .......||.||   .... | . || 
.gsvkledvlkalrkqralaitsale.lafvd
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2202-2276 1.2e-09 32.0 In-house 89-161 (349) alignment 
Range on Protein: 2202-2276
Range on HMM: 89-161/349.0
AEGYINANLVQLPVAPGENRHqaILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRKKV
 . ||||| ..|.    |...  |  | ||| |  | ....  .  .... ....||..  ||..||   . . .
lddyinanylkltrisvekky..iatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsysni
0043147 (Phosphotyrosine protein) phosphatases II 2203-2423 6.9e-37 122.2 In-house 5-155 (172) alignment 
Range on Protein: 2203-2423
Range on HMM: 5-155/172.0
EGYINANLVQLPVAPGEnrhqAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEkekghikchrywpvrkrkkvtarnftienlgvvkksgfnvstlqvH
. ||||... |.. | .     | .||||..|.|| |.|..|.. ..||..|..                                              
sdyinasyldlyyipdr....fiatqgplrntladfwrmlkelgithivnltel.............................................l

DSASGASREVMHFQFIDWPDHGVPsSAAQMVQMLREVAL-FQTSDAGPMAVHCSAGIGRSGVFVTLYTVLlaltlplR-AldvvarehfeytsiPVKEIV
  ... .|........ ||||||| ..... ..|. .   .. |. ||..||||||.||.|..| .| .|       .                .. |.|
ydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lgl..............sleeav

QKLREQRhPSVVQTSEQYLFVYK
. .||.| | .||. .|| |.|.
alvrekR.pgavqnpsqyrflyy
0051082 (Phosphotyrosine protein) phosphatases II 2203-2425 9.3e-31 101.8 In-house 3-149 (151) alignment 
Range on Protein: 2203-2425
Range on HMM: 3-149/151.0
EGYINANLVQlpvaPGenrhqAILCQGPLPetcaDMWQMVWEQDTRVIVMVTSEKEKGhiKCHRYWPVRKrkkvtarnftienlgvvkksgfnvstlqvh
..|||.. |     .|      ....|||.    | .....|.. ..||...||.| |  .|..|.|                                 
sdyinfsyvt....gg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..............................

dsasgasREVMHFQFIDWPDHGVPSSAAQMVQMLREVALfqtSDAGPMAVHCSAGIGRSGVFVTLYTVLLAltlplraldvvarehfeytsIPVKEIVQK
       .||.|....||||.|.| | ......|....     . ||..||||||.||.|..| || .||                     ... |... 
.......ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg....................vsleealee

LREQRHpSVVQTSEQYLFVYKAY
.|..|.  |||...|.||...|.
yrlkrp.gvvqpnqqflfqlfal
0036282 (Phosphotyrosine protein) phosphatases II 2204-2423 2.1e-37 123.8 In-house 3-164 (174) alignment 
Range on Protein: 2204-2423
Range on HMM: 3-164/174.0
GYINANLVQLPVAPGenrhQAILCQGPLPetcadMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVrkrkkvtarnftienlgvvkksgfnvstlqvhd
 ||||. . | . ..      |..||||.      |.|..|.. ...||...|||.|. ||..|||                                  
dyinaspldlsyitp....rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................

SASGASREVMHFQFIDWPDHGVPSSAAqMVQMLREVALFQTS-DAGPMAVHCSAGIGRSGVFVTLYTVLLALTlpLRALDVvarehfeytsipvKEIVQK
  .  .|........ |||||||...  . .....|  .. . . ||..||||||.||.|..| .| .|  |    .. |.              ..|..
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvda.............ldlvre

LREQrHPSVVQTSEQYLFVYK
|| |  | .||| .|| |.|.
lRlq.rpgmvqtpsQyrflyy
0046846 (Phosphotyrosine protein) phosphatases II 2205-2428 1.6e-40 134.0 In-house 14-172 (176) alignment 
Range on Protein: 2205-2428
Range on HMM: 14-172/176.0
YINANLVQLPVapgenrhqAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRKKVtarnftienlgvvkksgfnvstlqvhds
||||||.  .          | .|||||.|.|| ..|..|.. ...|..|.|.|.|..||..|||. .. ..                            
yinanlilgsr........piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

asgasrevmHFQFIDWPDHGVPSSaAQMVQMLREVALFQTSDaGPMAVHCSAGIGRSGVFVTLYTVllaltlplraldvvarehfEY-TSIPVKEIVQKL
         ......|||||||.. ... ..|...  ..... || .|||||||||.|..| .| .                   |.   ..| |.....
.........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayll...................elekglsveealalv

REQRHPSVVQTSEQYLFVYKAYVTL
||||.. .||| ||| |.|...  |
reqRplgavqtpeQyrflyefelll
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 2205-2325 9.8e-06 19.3 In-house 124-235 (244) alignment 
Range on Protein: 2205-2325
Range on HMM: 124-235/244.0
YINANLVQLPvapGeNRHQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKghikcHRYWPVRKRKKVTARNFTIENLGVVKKSGFNVSTLQVHDS
|||| .|      |    . || | || .|  |.|.|. |.   |.|.. | .|.       |||  .  .    . |.      .      | |..   
yinasfvgcl...g.rtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnleiesd

ASGASREVMHFQFIDWPDHGV
   . . .  ||  .||  | 
mneshqaltmfqisnwpsdgt
0049260 (Phosphotyrosine protein) phosphatases II 2222-2423 5e-37 122.3 In-house 9-144 (152) alignment 
Range on Protein: 2222-2423
Range on HMM: 9-144/152.0
HQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWpvrkrkkvtarnftienlgvvkksgfnvstlqvhdsasgasrevmHFQFIDWP
...| .|||.|.|.|| |.|..|.. ..|||.|.. |.|..||..|.                                             ..... ||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpwp

DHGVPSSAAQMVQMLREVALFQTSDAGPMAVHCSAGIGRSGVFVTLYTVLlaltlplraldvvarehfeyTSIPVKEIVQKLREQRhPSVVQTSEQYLFV
|||||...  . ..|. .  .. .. || .||||||.||.|..| .| .|                      ....|.|. .||.| | .|.. .|. |.
DhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml....................lgvsleeavalvrekR.pgavpnpgqlrfl

YK
|.
ye
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2222-2422 3.3e-21 70.4 In-house 5-197 (199) alignment 
Range on Protein: 2222-2422
Range on HMM: 5-197/199.0
HQAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRKKVTARNFTIENLGVVKKSGFNVSTLQVH--DSASGASREVMHFQFID
.. | .| || || ||.||||||  .  ||||  .. .       |||. .       ....    .. |. . ...| .    .|  ..||. |.||  
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPSSAA--QMVQMLREVAL-FQTSDAGPMAVHCSAGIGRSGVFVtlytvllaltlplrALDVVAREHFE--YTSIPVKEIVQKLREQRHpSVVQT
| ..  |  |    .|   |||.  ..     |. |||| | | .||||              |||.  | | |   . . . |. ..||. |   .. .
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfv..............aldigvrsheesktsvvdlfevakrlrqarc.giiss

SEQYLFVY
 ..| |.|
lqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2223-2422 3.2e-21 70.4 In-house 5-196 (198) alignment 
Range on Protein: 2223-2422
Range on HMM: 5-196/198.0
QAILCQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRKKVTARNFTIENLGVVKKSGFNVSTLQVH--DSASGASREVMHFQFIDW
. | .| || || ||.||||||  .  ||||  .. .       |||. .       ....    .. |. . ...| .    .|  ..||. |.||  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGVPSSAA--QMVQMLREVAL-FQTSDAGPMAVHCSAGIGRSGVFVtlytvllaltlplrALDVVAREHFE--YTSIPVKEIVQKLREQRHpSVVQTS
 ..  |  |    .|   |||.  ..     |. |||| | | .||||              |||.  | | |   . . . |. ..||. |   .. . 
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfv..............aldigvrsheesktsvvdlfevakrlrqarc.giissl

EQYLFVY
..| |.|
qhynfiy
0044763 (Phosphotyrosine protein) phosphatases II 2224-2429 4.6e-30 100.0 In-house 30-171 (178) alignment 
Range on Protein: 2224-2429
Range on HMM: 30-171/178.0
AILCQGPLpetcADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRkkvtarnftienlgvvkksgfnvstlqvhdsasgasrevMHFQFIDWPDH
 .|.. |     || .....|.. ..||..|.|.| |..||..||| .                                         .....| .|||
lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.......................................iqylhipipDh

GVPSSAAQMVQMLREVALFQTSDAGPMAVHCSAGIGRSGVFVTLYTVLLAltlplraldvvarehfeytSIPVKEIVQKLREQRHpsVVQTSEQYLFVYK
|||.. ... .... .  .. .. || .||||||.||||..| .| ..                     .... |... .||.|   .|.. .|. ..|.
gvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl...................glsleeaielvrerRp..ivpnpgqlrqLye

AYVTLL
 .  ||
felrll
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2225-2410 6.9e-19 62.9 In-house 38-203 (255) alignment 
Range on Protein: 2225-2410
Range on HMM: 38-203/255.0
ILcqgplpeTCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRKKVTARNFTIENLGVVKKSgfNVSTLQVHDSA--SGASREVMHFQFIDWPD
.|       | . ..|..  ..| |.||..  .|.|  ||..|.|. | .|    . ..     . .    . ||..          ..| |...  |..
sl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadv..vlrtleitstlgekkkthtvkhysykGWie

HGVPSSAAQMVQMLREValfqtSDAGPMAVHCSAGIGRSGVFVTLYTVLLALtlpLRALDVVAREHFEYTSipvkeIVQKLREQRHPS
.  |  | .. ..|. |      |. .. ||||.|||||  ||    |   .   .|.||     ...| |     ....||..|. .
knaPelareilnilkvv.....rdsksvvvhCstGiGrsaafvlaelvyqkm...irsldttetveldyls.....lleelrskrkra
subfamily_hpo-7_pd Subfamily hpo-7 2226-2410 4.9e-16 53.4 In-house 42-209 (263) alignment 
Range on Protein: 2226-2410
Range on HMM: 42-209/263.0
LcqgpLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRKKVTARNFTIENLGVVKksGFNVSTLQVHDSA--SGASREVMHFQFIDWPDH
|    | .| . ..|..  . | |.||..  .|.|  || .|.|. | .|    | ..    |..     . ||..          ..| |...  |...
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiek

GVPSSAAQMVQMLREValfqtSDAGPMAVHCSAGIGRSGVFVTLYTVLLALtlpLRALDVVAREHFEYTSipvkeIVQKLREQRHPS
  |  | .....|. .      .  .. ||||.|||||  |.   .|   .   .|.||     ...| |     ....||..|. .
ndpelareilnilkva.....rnskslvvhcstGiGrsaafsvaElvyqkm...irsldttstveldyls.....Lleelrssrkra
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2227-2368 4.1e-15 50.0 In-house 96-243 (302) alignment 
Range on Protein: 2227-2368
Range on HMM: 96-243/302.0
CQGPLPETCADMWQMVWEQDTRVIVMVTSEKEKGHIKCHRYWPVRKRKKVTARNFTIENLGV-------VKKSGFNVSTLQVHDSASG--ASREVMHFQF
   |  .|.   | .. . .. ..| ..| .|... ||  |.  . ..... ...|.. . |         | .|.. |......       . |  ..|
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

IDWPDHGVPSSAAQMVQMLREVALFQTSdagpMAVHCSAGIGRSGVFVTL-Y
  ||||| |  | . ...|.    ....    . ||||||.||.| .|.. |
sawpdhGapkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaiky
0048076 (Phosphotyrosine protein) phosphatases II 2298-2428 6e-24 79.8 In-house 32-142 (145) alignment 
Range on Protein: 2298-2428
Range on HMM: 32-142/145.0
T-LQVHDSASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSDaGPMAVHCSAGIGRSGVFVTLYTVLLaltlplraldvvarehfeyTSIPV
| | . .  .. .|.........|||||||...... ..|. .  .. .. ||..||||||.||.|..| .| .||                    ....
tvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll...................lgvsl

KEIVQKLREQRhPSVVQTSEQYLFVYKAYVTL
 |.....|.|| | .|.. .|. |.|...  |
eealelvrsqr.pgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 2304-2423 6.7e-22 73.2 In-house 41-139 (144) alignment 
Range on Protein: 2304-2423
Range on HMM: 41-139/144.0
SASGASREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSDaGPMAVHCSAGIGRSGVFVTLYTVLlaltlplraldvvarehfeYTSIPVKEIVQKL
      ||........|||||||...... ..|. .  .. .. ||..||||||.||.|..|..| ..                   .  ....|... .
epefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk...................klglsleealalv

REQRhPSVVQTSEQYLFVYK
|..| | .|.. .|. |...
rsrr.pgavpnpgqlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2309-2427 1.2e-12 41.9 In-house 88-192 (440) alignment 
Range on Protein: 2309-2427
Range on HMM: 88-192/440.0
SREVMHFQFIDWPDHGVPSSAAQMVQMLREVALFQT-SDAGPMAVHCSAGIGRSGVFVtlytvllaltlplrALDVVAREHFEYTSIPVKEIVQKLREQR
|| . ....  |||.|||  |. ...|...|   |  .  ||. |||||| ||.|| .              |.| . ||      | .  ... .|..|
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgvii..............avdsilreakrsdqidifsfinsmrnnr

hPSVVQTSEQYLFVYKAYVT
 | .||| ||| ||..| . 
.pqmvqtpeqyafvheavle
subfamily_PTPDC1_pd Subfamily PTPDC1 2309-2405 3.2e-08 28.2 In-house 80-170 (182) alignment 
Range on Protein: 2309-2405
Range on HMM: 80-170/182.0
SREVMHFQFiDWPDHGVPSsAAQMVQMLREVAlFqTSDAGPMAVHCSAGIGRSGVFVTLYTVLLALTLPLRALDVVAREHfeYTSIPVKEIVQKLRE
 .......|  |.|.||.|   ..... . || | . . | .|||| || || || .. | |      . .|...|  .     ||  .| |. ..|
eqgiyvynf.gwkDygvas.leriLdivkvva.f.alqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskr..pksiqtreqvelvke
PTPc_DSPc_SM00012 2312-2425 2.9e-27 90.3 In-house 2-103 (105) alignment 
Range on Protein: 2312-2425
Range on HMM: 2-103/105.0
VMHFQFIDWPDHGVPSSAAQMVQMLREVALFQTSD--AGPMAVHCSAGIGRSGVFVTLYTVLLALTLPLraldvvarehfeyTSIPVKEIVQKLREQRhP
|.|... .|||||||...  ....||.|  ...    ..|. ||||||.||.|.||.|...|  |.                ... ...||..||.|| |
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket.............kevdifqivkelrkqR.p

SVVQTSEQYLFVYKAY
..||| |||||.|.| 
gmvqteeqylflyral
PTEN_1 2313-2368 5e-06 21.5 In-house 93-151 (196) alignment 
Range on Protein: 2313-2368
Range on HMM: 93-151/196.0
MHFQ--FIDWPDHGVPSSAaQMVQMLREVALFQTS--DAGPMAVHCSAGIGRSGVFVTLY
....   ....|||.|| . ..  ......    |  . .  .||| ||.||||. |  |
sgveylhfpieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaay
0038934 (Phosphotyrosine protein) phosphatases II 2314-2372 1.4e-08 30.1 In-house 81-140 (194) alignment 
Range on Protein: 2314-2372
Range on HMM: 81-140/194.0
HFQFIDWPDHGVPSSAAQMVQMLREVALFQTSD-AGPMAVHCSAGIGRSGVFVTLYTVLL
..  . .||.|.. | ... . |. |  |   |  |  |||| ||.||.|..|  | .  
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2334-2427 2.1e-10 34.5 In-house 252-342 (349) alignment 
Range on Protein: 2334-2427
Range on HMM: 252-342/349.0
QMLREVALFQTSDAGPMAVHCSAGIGRSGVFVTLYTVLLALTLPlrALDVVAREHFEYTSIPVKEIVQKLREQRHpSVVQTSEQYLFVYKAYVT
  |     ..|..  .. |||||| ||.||.|||  .|  |. .    . .  .    .  ..  || .|| ||  |.||   |. ..|.|.. 
ddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsilepl..qnesnkiklqallkDlisiivnelrkqri.smvqnlaqfiaiyealLk
subfamily_CG42327_pd Subfamily CG42327 2345-2425 8.5e-08 26.2 In-house 245-311 (319) alignment 
Range on Protein: 2345-2425
Range on HMM: 245-311/319.0
SDAGPMAVHCSAGIGRSGVFVtlytvllALTLPLRALDVVARehfeytSIPVKEIVQKLREQRHpSVVQTSEQYLFVYKAY
.. ||..|||| |.||.|. .       |  . .| |.   |      |. . ..|. .|..|  | |.| ||| |.||  
esqGPlvvhcsdGvGrtGlvi.......asdiairsleeskr......svdiPqlvssvrrdra.savltkeqyefiykvl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2348-2425 1.8e-08 28.6 In-house 229-291 (297) alignment 
Range on Protein: 2348-2425
Range on HMM: 229-291/297.0
GPMAVHCSAGIGRSGVFVTlYTVLLALTlplraldvvAREHfeytsIP-VKEIVQKLREQRhPSVVQTSEQYLFVYKAY
 .. ||||||.||||| |    |.|| .          ...     || |. |...||||| . .||| ||. ..|.| 
ayllvhcsaGvGrsGvvvl.sdvilakl.........rkkr.....ipdvaailsilreqr.arlvqtleqfellydav