Gene PTPN6 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN6
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP068_AA protein Get Run
MbreP068_AA_224-493 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
SH2 SH2 domain 3-78 1.9e-26 82.5 Pfam-A 1-77 (77) alignment 
Range on Protein: 3-78
Range on HMM: 1-77/77.0
WFHPNISGEEAERMLLTQGFDGSFLVRQSRSNKGDYALSVRRGASVTHIKIQNSGDF-LDLYGGEKFANLTELIQFY
|.| .||.|||||.||... ||.||||.|.|..|||.|||..  .|.|..||.. .  . . ..||| .|.||...|
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLvehY
SH2 SH2 domain 109-184 7.3e-22 67.8 Pfam-A 1-77 (77) alignment 
Range on Protein: 109-184
Range on HMM: 1-77/77.0
WFHGQMSGPDSEAALRERGEHGSFLVRASQSQPGRFALSVRCGDAISHIIIRNNGGS-FDVGGGASFTDLTSLVEYY
|.||..|. . | .|.|....|.|||| |.|.|| ..|||.  . . |. |...  . . . ....| .|. |||.|
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLvehY
subfamily_PTPN6_pd Subfamily PTPN6 206-496 7.5e-117 384.7 In-house 2-286 (306) alignment 
Range on Protein: 206-496
Range on HMM: 2-286/306.0
TRLNLASIDGRFIELSKarseTEEEFGKAGFNEEFEQLQTMEHQHKFDRMEGARIENKSKNRYKNILPYDHTRVKLRnvPDGVIGADYINANFINGEAPG
|.|. ..|. |  ||.|    .||...||||.||||.||..|......|.|||..|||.|||||||||.|||||.|.   ..|.|.||||||.|..|..|
tsllakeieqrvselek....eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevkg

TDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERRPArFGNYVVELLTEDNFDAYTVRRMSVA--VGEGDPREIYQYHYT
.||.|||.||....||.|||.|....|.|..||.|. ||.||.||..|||..|.... .|.. |. ..|.. ..|..|..||.    ... ||..|||..
sdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfk

SWPDHGVPPERE-FLQLIMKIRQHRDRLRKSipGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIDCDIDIQSIIHKLRGQRSGMIQTAVCY
|||||||| ... .|............|...    ||..|||||||||||||.||||.|.||.. |.|.|||||......| ||||..||. .|
sWPdhgvpkdpgavLdfledvnrkqeeleea..eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqy
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 223-495 1.4e-64 213.2 In-house 16-278 (298) alignment 
Range on Protein: 223-495
Range on HMM: 16-278/298.0
ARSETEEEFGKAGFNEEFEQLQTMEHQ-HKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPdGVIGADYINANFINGEApGTDkAYIASQGTMPDTV
 ... ..... .|...||..|...... ...    . . |||.|||| .|...|..|| |...  .   .||||| |...   |.. |.||.|. .. ||
klaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked.adeesdYiNAsflhayk.grn.afiatqaPltetv

ADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSerRPARFGNYVVELLTEDNFDAYTVRRMSV-AVGEGDPREIYQYHYTSWPDHGVPPER-EFLQL
.|||.|..|..   .|| || .|..| |.. |||..  . ...|.  |.|| ...|  ..||.. |    | . ||. | |.|||||.||| .    |.|
edFWrmvteedigtiVmltnleeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldl

IMKIRQhrdrlRKSIPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRhygIDCDIDIQSIIHKLRGQRSGMIQTAVC
. |.|.      ..  |  | .|.||||.||.||| .|| ||. ..   ..  .|.  ... || .| |..||   
lrkvra.....sqqqagnkpvivqCsaGvgRsGtfiaidsvlervk...keqvvDvfqvvkvlRkkrpgavqteeq
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 224-494 2.7e-70 232.0 In-house 13-270 (319) alignment 
Range on Protein: 224-494
Range on HMM: 13-270/319.0
RSETEEEFGKAGFNEEFEQLQTMEHQhkfDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDgVIGADYINANFINGEApgTDKAYIASQGTMPDTVAD
| .. .. |. ....||..|.. . .   .  .  . |||.||||.|||.||.|||.| .... | |.|||||.||.|      ...|| |. . .|. |
rlkalastgetllekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldg.vegsdyinasfidgyq..erekfiatqaPlentied

FWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSErrPARFGNYVVELLTEDNFDAYTVRRMSVAVGEGDP--REIYQYHYTSWPDHGVPPER-EFLQLI
||.|. |...  ||| |. |||.| |.  |||. .  . ..|...|.|. |.. . | .|....    ..   ||. ...||.||||.|| .    |.|.
fWrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldll

MKIRQHRDRlrksiPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTAV
 .||. |..     .  ||  ||||||.||||||.|.|..|. ... |.   .|. |.. .|| ||  |.|.  
krirksrek.....tqsgPivvhCsaGvGRtGtfivldamlervkeegv...lDvfstvsrlRtqRnimvqrpe
0050432 (Phosphotyrosine protein) phosphatases II 226-494 2.9e-88 291.5 In-house 34-286 (308) alignment 
Range on Protein: 226-494
Range on HMM: 34-286/308.0
ETEEEFGKAGFNEEFEQLQTMEHqhKFDRMEGARIENKSKNRYKNILPYDHTRVKLrnvpDgvIGADYINANFINGEAPGTDKAYIASQGTMPDTVADFW
  |. ... ...||||.|. .     ...  ... |||.|||||.||||||.||||    |   | |||||....|   . ....|| || .|.||.|||
llekaldlglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl....d..egsdYInAsyvdgyssklprkfIatqgPlpntvedFw

QMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSER-RPARFGNYVVELLTEDNFDAYTVRRMSVAV-GEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMK
.|. |||.|..|| |..||.|. || .|||...   . ..|...|.|| |...| |||| . .   |.|. |.....|||.||||||||. ...|... .
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflel

IRQHRdrlRKsipglGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYgidCDIDIQSIIHKLRGQRSGMIQTAV
.|...   ..     ||..||||||.||||||...|..|.....    . .|......||| || ||.||  
vrksl...pg.....gpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpe
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 226-494 3.5e-59 195.2 In-house 12-265 (287) alignment 
Range on Protein: 226-494
Range on HMM: 12-265/287.0
ETEEEFGKAGFNEEFEQLQTMEHQHKfDRMEGARIENKSKNRYKNILPYDHTRVKLRnvpdgVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFW
..... |. ||.. |  |. ...... .   .   .|| |||...||..|  || |.         ||||| ||.|     .||.|.... | .|. .||
akghakgnegfknqftvleqvtqred.evthniasqnkdknRltqilvpdnyrvllk.....gehpdyinavfidgyk..ekkafiiaesPmfntarnfW

QMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERrpARFGNYVVELLTEDNFDAYTVRRMSVAVGE--GDPREIYQYHYTSWPDHGVPPEREFLQLIMKI
..| ..|   .|| ..  |. ...|  |||...     .|.| .||| |.  . |..|.. |   .  ||.... ||..|.|...|  .| .   |... 
kliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillviee

RQHRDrlRKsiPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTAV
. . .  ||  .| .. .||||...||...|. ... ..  .  |.   ||. ..... | |. |..||. 
myktq..rk..rgntsivvhCsdtvGrsamfcaaattinkckteGv...iDvfqvlksqriqkpgsvqtve
0047943 (Phosphotyrosine protein) phosphatases II 228-494 5.3e-83 273.9 In-house 6-259 (273) alignment 
Range on Protein: 228-494
Range on HMM: 6-259/273.0
EEEFGKAGFNEEFEQLQTMEHqhKFDRMEGARIENKSKNRYKNILPYDHTRVKLrnvpdGVIGADYINANFINGeaPGTDKAYIASQGTMPDTVADFWQM
|. .|.... ||||.|. . .   ...  ....|||.|||||.||||||.||||     |  | |||||....|  . . ...|| || .|.||.|||.|
ekllgltllleefelllslkp..lltysvallpenkdknrykdilpydhsrvkl.....gdggsdyinAsyvdg..ynlkrkfiatqgPlpntvedfwrm

IVEQNCRLVVMATNPVEKGKHKCTPYWPSSERR-PARFGNYVVELLTEDNFDAYTVRRMSVAV-GEGDPREIYQYHYTSWPDHGVP-PEREFLQLIMKIR
. |||.|..|| |..||.|. || .|||...   . ..|.. |.|| |...| |||| . .   | |..|.....|||.|||||||    ..|..|...|
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

QHRDRLRKSipglGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGidcDIDIQSIIHKLRGQRSGMIQTAV
...  |...    ||..||||||.||||||...|..||.....|    .|. .....|| || ||.||  
kalealpsn....gpvvVHCsaGvgRtgtfialdllldqlekeg...gvdvleavkllrsqRpgmvqtpe
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 228-496 3.1e-76 251.2 In-house 15-268 (288) alignment 
Range on Protein: 228-496
Range on HMM: 15-268/288.0
EEEFGKAGFNEEFEQLQTMEHQHKFDrmEGARIENKSKNRYKNILPYDHTRVKLRNVPDgVIGADYINANFINGEapGTDKAYIASQGTMPDTVADFWQM
 .  ...||.||...| ..|.... .   | . .|..||||.||||||..||||..... . |||||||..|.||  . .|.|||.|| ..||| |||..
ksarnrtgfseeynsLaalektksvt..agrlavnakknRyrnilpyDekrvklkklee.eagaDYinasyidge..kkkkkyiatqgPladtvndfWel

IVEQNCRLVVMATNPVEKGKHKCTPYWPSSERrPARFGNYVVELLTEDNFDAYTVRRMSVAvGEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQH
. |..   .|| |. ||.||.||  |||.... | ..|.  |.|. . . . ...|.. .   ... .|| ||.|..|||||||   ...|.|. .. . 
vyenktstivmltelveggktkCeeYWPdadk.pknyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhgvPeskapllellrqvkva

RDRLrksipgLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTAVCY
 .        .|| .||||||.||||||...| ..| ...   .  ||. ....||| ||  ..||   |
nqad......tgpiivhCsaGvGrtgtFialdalidavee...edyiDvagtvaklRkqRallvqtlkqY
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 228-496 3.3e-69 228.1 In-house 9-265 (281) alignment 
Range on Protein: 228-496
Range on HMM: 9-265/281.0
EEEFGKAGFNEEFEQLQTMEHQHKFDrmEGARIENKSKNRYKNILPYDHTRVKLRNVPDGvIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQM
...  .||| ||.|.|. .. ..        . ||. ||||.||  ||.||||. .  .    .|||||||..|     .|.|||.|| .|.....||||
lsqndnaGfieeyeklaaigvdntat..askadenvlknrYsnivaYDatrvkvtpneen.kntDYinanfvpgyk..gekeyiatqgPvPaslvafWqm

IVEQNCRLVVMATNPVEKGKHKCTPYWPsSERRPARFGNYVVELLTEDNFDAYTVRRMSVAVGEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQH
..||. ...|| |. .|.|| ||  |||  ..   ..|...|. ..| .   |  |....   .|..||. | .||.||||||| . .|.|.   .... 
vweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkl

RDRLRKsipglGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGidCDIDIQSIIHKLRGQRSGMIQTAVCY
... .|      | ..|||||.|||||.. .| ... . .     ..|.. ....|| .|  |.|| |.|
tekktk.....aplvihCsaGvGrtGtyialDrlvkaveael..eeldvkavvaelrkernlmvqtvvqy
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 228-496 8e-62 203.7 In-house 14-272 (290) alignment 
Range on Protein: 228-496
Range on HMM: 14-272/290.0
EEEFGKAGFNEEFEQLQTMEHQHKFdrMEGARIENKSKNRYKNILPYDHTRVKLRNVPDG-VIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQ
..  |. ||...|..|.. |..|.   . |   .|| .||..||..||  |. ||....      .|||| .|.|     .|.||| || ...|..|||.
ghakgnegfrnqfkmldsgesehtv..tvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgyk..ekkqyiatqgpvsntlvdFWk

MIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERRParFGNYVVELLTEDNFDAYTVRRMSVAVGE--GDPREIYQYHYTSWPDHGVPPEREFLQLIMKIR
.|.....  .|| || .|.||.||  |||.|. .   .|.. ..|| | ... |. |...|   .  |..... ||. |.|...|  ....   |... .
liwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieem

QhrDRLRKSipGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGidcDIDIQSIIHKLRGQRSGMIQTAVCY
.  .  ||.  | .. .||||...||...|..... ..  .  |    ||. ......| |. |..||...|
y..ktqrkr..gntsivvHCSdtvgrsavfcaaattinkckteg...vidvfqvlksqRiqkpgsvqtvqqy
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 228-495 7.7e-16 52.4 In-house 20-273 (302) alignment 
Range on Protein: 228-495
Range on HMM: 20-273/302.0
EEEFGKAGFNEEFEQLQTMEHQhkFDRmEGARIENKSKNRYKNILPYDHTRVKLRNVPDgvigaDYINANFINgeAPGTDKAYIASQGTMPDTV---ADF
 ... .|  ..||....||  .   ..   |  .| .||. ...  .|...||| . ||     .|.||  ..   |   .  | .|    |..   ..|
vksldtaevkkefkkidtmkvd..lek.Ckafkknlkknqsedvpildsnlvkleaepd.....syvnaskve..vPeltrsiilaQlpkvdsedsveeF

WQMIVEQNCRLVVMATNPVEKGKhKCTPYWPSSERRPARFGNYVVEL-----LTEDNfDAYTVRRMSVAVGEGDPREIyqYHYTSWPDHGVPpeREFLQL
|.|. ....  ||..  . |  |     ..|        .|.  |         |.. ..|..  .   . .    ..  |. | |... ||   .. .|
Wrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanv..yvltnWkqkkvp..vkyael

IMKIRQHrdrLRKSIPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYgidCDIDIQSIIHKLRGQRSGMIQTAVC
| .. .      |.|..  .|..    |.|| |.||.  .... . .     .  |. |....| ||. .....  
iktaakv...fakkikadentvivSknGaGRagafltlavaveklqkg...kepnikeivksiRsqRpravdslkQ
0036941 (Phosphotyrosine protein) phosphatases II 229-493 1e-83 276.4 In-house 8-263 (297) alignment 
Range on Protein: 229-493
Range on HMM: 8-263/297.0
EEFGKAGFNEEFEQLqtMEHQHKFDRMEGARIENKSKNRYKNILPYDHTRVKLrnvpDGvIGADYINANFIngEAPGTDKAYIASQGTMPDTVADFWQMI
. ...|.. .|||.|  ..... ...  ... ||..|||||.|||||||||||    |.  | |||||...  . .. ....|| || .|.||.|||.|.
kllflalllkefeel..lpllllgslsvallpenleknRykdilpydhtRVkl....dd.egsdYinAsyv..dgydlkrkfIatqgPlpntvedFWrmv

VEQNCRLVVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLTEDN--FDAYTVRRMSVAV-GEGDPREIYQYHYTSWPDHGVPP-EREFLQLIMKIR
 |||.. .|| |..||.|. || .|||. |. .  .|...|.||...   .| ||.| . |   |.|..|.....|||.|||||||.  ...|..| ..|
weqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvr

QHRDRLRKSipglGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIDCDIDIQSIIHKLRGQRSGMIQTA
.... |...    ||.|||||||.||.|||...|..|...... . . .|| ....||| || |..|| 
kvlkllpsg....gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtl
subfamily_PTPN12_pd Subfamily PTPN12 229-493 4e-78 257.2 In-house 3-263 (290) alignment 
Range on Protein: 229-493
Range on HMM: 3-263/290.0
EEFGKAGFNEEFEQLQTMEHQHKFDR----MEGARIENKSKNRYKNILPYDHTRVKLRNVpDGVIGADYINANFINGeaPGTDKAYIASQGTMPDTVADF
|. |.. |..||..|.......| ..     .| . ||. |||||.|||||..||.|..  ... | ||||||||.|  .  ...|||.|| .|.|. ||
ekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelski.eeeegsdYinanfikg..vegkleyiaaqgPLpktlddf

WQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLTEDNFD-AYTVRRMSVAVGeGDPREIYQYHYTSWPDHGVPPE-REFLQLIMK
|.|| |.| ..|||| . || ||.||  |||..  .. .||.. |.| .|...|  ...| . | .  .. |..||.|||.|||||||    . |.|| .
WrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvPssakslleliel

IRQHRDrlRKSIpglgPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIDCDIDIQSIIHKLRGQRSGMIQTA
.|....  ....    | .||||||.||||| ..||.| .|...  |. ..|. ... .|| ||. ..|| 
vrelqe..seda....PlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtk
0039614 (Phosphotyrosine protein) phosphatases II 230-493 5.1e-82 270.9 In-house 28-275 (297) alignment 
Range on Protein: 230-493
Range on HMM: 28-275/297.0
EFGKAGFNEEFEQLQTMEHqhkfDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDGVIGADYINANFINGeaPGT-DKAYIASQGTMPDTVADFWQMI
 ..| .. .|||.|. . .    |. .....|||.|||||.||||||.||||  ... . . |||||....|  .   ....||.|| .|.||.|||.|.
ansktllllefeellslkp....dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdg..ydlltrkfIatqgPlpetvedFwrmv

VEQNCRLVVMATNPVEKGKhKCTPYWPSSERrpaRFGNYVVELLTEDNFDAYTVRRMSVAVgEGDPREIYQYHYTSWPDHGVPP-EREFLQLIMKIRQHR
 ||... .|| |..||.|. || .|||...    ..|...|.||...  | |||| ..|   .| .|......||.||||||||  . .|... ..|...
weqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvreal

DRLrksiPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYgidCDIDIQSIIHKLRGQRSGMIQTA
 .|    |. ||.|||||||.||||||......|......   ...|.......|| ||.|..|| 
ael....pkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtp
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 230-494 1.2e-78 259.4 In-house 16-267 (318) alignment 
Range on Protein: 230-494
Range on HMM: 16-267/318.0
EFGKAGFNEEFEQLQTM-EHQHKFDRmegARIENKSKNRYKNILPYDHTRVKLRNVPdGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMI
| |.  ..||.|.|.   |.  ...        || |||| |||.||||||||...  |. |.||||||.|.|     .|||||.|. .|.|. |||.|.
esGelllseeyerlsrseetvtslks...lepvnkaknryanilaydhtrvkLqmle.geegsDyinanyidGyr..rkkayiaaqaPlpetieDfWrmv

VEQNCRLVVMATNPVEKGKHKCTPYWPSSErrPARFGNYVVELLTEDNFDAYTVRRMSVAV-GEGDPREIYQYHYTSWPDHGVPPERefLQLIMKIRQHR
 |||....|| |. .|.||.|.  ||||..  .  .|. ||||  | ... |..|...|   .| . |.. |||||||||.||| .    .|.  .|| .
WeqnsavivmltqeeergkakvhryWPskg..srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg..aslldlvrqvs

DRlrKSIPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTAV
    .  .| ||..||||||.||||.|...||.|. |.. ..   .|.  ....|| ||  |.||  
ka..qqksgagpivvhCsaGvGrtGvfiavdillerikaeal...vDvfqtvkqlreqrnlmvqted
subfamily_PTPN9_pd Subfamily PTPN9 230-493 3.5e-66 218.3 In-house 12-276 (297) alignment 
Range on Protein: 230-493
Range on HMM: 12-276/297.0
EFGKAGFNEEFEQLQTMEHQHKFDRMEgaRIENKSKNRYKNILPYDHTRVKLRNVPDGvIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIV
| || |  .|..... .. . .|....     | .||||...| ||.|||.| .|..    .|||||||..|      ||.|| ||... || |||.|. 
ekgkrGlskeyaeirnepveGtflask..lranleknrytdvlcydetrvvlakvded.easdyinanfvdGyk..qkkafiatqGplkktvsdfWrmvW

EQNCRLVVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLTEDNFDAYTVRRMSVA-VGEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHR
||... .||.|  ||.|. ||. |||..|   |.||.. |. .  .. ..|.|| . .  | ... |..  . ..||||.||| .  ..|... |.|...
eqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekq

DRLRKSI-------PGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTA
  . |..       |   | .|||||||||||||  .|| |. ... |    .|..  ...|| ||. .||| 
alavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgt...vdvvetvkllrtqrafsiqtp
0051299 (Phosphotyrosine protein) phosphatases II 231-493 5.3e-85 280.6 In-house 20-272 (288) alignment 
Range on Protein: 231-493
Range on HMM: 20-272/288.0
FGKAGFNEEFEQLQTMEHQhkFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDgVIGADYINANFINGeaPGTDKAYIASQGTMPDTVADFWQMIVE
 |..|. ||||.|. . ..  ...  ... ||..||||..||||||.||||..... | | |||||..|.|  . .....|| || .|.||.|||.|. |
ngltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldg.vegsdYinAsyidg..ynlkrkfIatqgPlpntvedFWrmvwe

QNCRLVVMATNPVEKGKHKCTPYWPSseRRPARFGNYVVELLTEDNFDAYTVRRMSVAV-----GEGDPREIYQYHYTSWPDHGVPP-EREFLQLIMKIR
||.|..|| |..||.|. || .|||.  . .  .|...|.|| |. .| |||| . |       |.| .|.....|||.|||||||.  ...|......|
qnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvr

QHRDrlrksiPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYgidCDIDIQSIIHKLRGQRSGMIQTA
...       .| ||..||||||.||||||...|..|.....      .|. .....|| || ||.|| 
kala......sgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtp
0043336 (Phosphotyrosine protein) phosphatases II 231-494 7.2e-79 260.4 In-house 17-264 (278) alignment 
Range on Protein: 231-494
Range on HMM: 17-264/278.0
FGKAGFNEEFEQLQTMEHqhkFDRMEGARIENKSKNRYKNILPYDHTRVKLrNVPDGVIGADYINANFINGeaPGTDKAYIASQGTMPDTVADFWQMIVE
 .|... .|||.|... .   ...  ....|||.|||||.||||||.|||| .. .|. . |||||....|  .   ...||.|| .|.||.|||.|. |
nlktllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvkl.sllggdldsdYinAsyvdg..ynvprkfiatqgPlpetvedFwrmvwe

QNCRLVVMATNPVEKGKHKCTPYWPsseRRPARFGNYVVELLTEDNFDAYTVRRMSVAV-GEGDPREIYQYHYTSWPDHGVP-PEREFLQLIMKIRQHRD
.... .|| |..||.|. || .|||   . . ..|...|.|| |. .| |||| . |   |.| .|....|||..||||||| .   .|... ..|....
lgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale

rlrksiPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGidcDIDIQSIIHKLRGQRSGMIQTAV
      .  ||.|||||||.||||||......|......|    .|.......|| || |..||  
......dsngpvlVHCsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtps
subfamily_Ptp69D_pd Subfamily Ptp69D 231-492 1.4e-61 203.3 In-house 19-271 (307) alignment 
Range on Protein: 231-492
Range on HMM: 19-271/307.0
FGKAGFNEEFEQLQTMehQHKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPdGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVE
  . |. .|.|.|..   . . .   ... ||. ||||..| ..|.|||||.... |   .|||||.||.|      | .||.|. .  |. |||.|| |
dtdfglakeyekLear..eidkstkvsekkenalknRyedikafDktRvkLkkin.gkedsdYinasfikgyk..ekkkfiaaqdPveatigDfWRmiae

QNCRLVVMATNPVEKGKHKCTPYWPSSerRPARFGNYVVELLTEDNFDAYTVRRMSVAVGE------GDPREIYQYHYTSWPDHGVPPE-REFLQLIMKI
|.  |.|| .|  || ..||  |||       ..|. .|.|  |.. . |. | ..|.  .       | |.. |||||.|.|  ||   |  |.|| ..
qevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqv

RQHRDRLrksipgLGPTLVHCSAGIGRTGTFLVIDIVLDlirHYGIDCDIDIQSIIHKLRGQRSGMIQT
|..           .| .|||||| ||.|.|. .|..|.   .   .  .||  ....|| ||. ..| 
relykln......rsPivvhCsaGvgrsgifvaldsllq...qlkaedkvdifetvkdLrsqRnllvqs
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 231-495 4.6e-38 125.7 In-house 19-275 (305) alignment 
Range on Protein: 231-495
Range on HMM: 19-275/305.0
FGKAGFNEEFEQLQTMEhqhKFDRMEGAR-IENKSKNRYKNILPYDHTRVKLrnvpDGVIGADYINANFINgeAPGTDKAYIASQGTMPDTVADFWQMIV
 | ||. .||  .. ..    |..|.  .  ... |||||..   |. ||||    .|    .|| ||..   .|   | .| .|  . .| |||| | .
kgpaglraefvamkrfn...dfekmkafkeaqeagknrykdvgcldnnrvkl....egpwpheyihanyvs..tptnpkrfictqaplektcadfwymcl

EQNCRLVVMATNPVEKGKHKCTPYWPSSERRPARFGNYV--V--------ELLTEDNFDAYTVRRMSVAVGEG-DPREIYQYHYTSWPDHGVPPER-EFL
...   . |  | .||| .||. |..| ..    | .    .        .|  ... .|   . . |  | | . | . .||.  ||| |||.     |
qdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlail

QLIMKIRqhrdrlrksiPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGI-DcdiDIQSIIHKLRGQRSGMIQTAVC
.|. | |          |  ||. |||||||||||. .... .|| .    | .   | . |. |.| ||   |||   
ellekar..........pskgpivvhcsagigrtgsvvmleyildqllagqiie...dtdkilqkireqrnnsiqtdaq
subfamily_PTPRD_pd Subfamily PTPRD 232-494 1.1e-89 296.6 In-house 21-268 (564) alignment 
Range on Protein: 232-494
Range on HMM: 21-268/564.0
GKAGFNEEFEQLQTMeHQHKFDRMEGARieNKSKNRYKNILPYDHTRVKLRNVPdGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQ
... |.||......  .|....  .     ||.||||.||..|||.||.|..|. |. | |||||.||.|    ..|||||.|| ...|..|||.|. ||
sdlkfeeeykkieeg.qqftweaankpa..NkaKNRyanivaYdhsRVvLskve.gdegsDYINAsfidgyr..krkayIAtqgPlaetiedFWRmvweq

NCRLVVMATNPVEKGKHKCTPYWPSSeRrPARFGNYVVELLTEDNFDAYTVRRMSV-AVGEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRDr
|.. .|| |. .||||.||  |||.. . ....|...|.|  | ..  |..| ...    . . ||. |.|.||||||||| . ...|.||.|.|...  
nsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne.

lrksiPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTAV
     |. ||..||||||.||||||.|||..|. |..   . ..|| .....|| ||  |.||  
.....pdagPivVhCSaGVGRTGtfividamlerike...ektvDiyqyvkalrkqRnamVqtee
0045450 (Phosphotyrosine protein) phosphatases II 232-493 1.2e-83 276.7 In-house 25-290 (307) alignment 
Range on Protein: 232-493
Range on HMM: 25-290/307.0
GKAGFNEEFEQLQTMEHQHKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDGVIGADYINANFING------EAPGTDKAYIASQGTMPDTVADFW
...|. .|||.|. ..... ... .... |||.|||||.||||||||||| .... . . |||||....       . .  ....|| || .|.||.|||
fltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFw

QMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSeRRPARFGNYVVELLTEDNFDAYTVRRMSVAV--GEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMK
.|. ||.....|| |..||.|. || .|||.. . .  .||..|.|| |.  | ||||.. |    |.| .|.....|||.||||||||   |.|..| .
rmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

IRQHRDRLRKSipglGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIDCDIDIQSIIHKLRGQRSGMIQTA
.|.....|.|.    ||.|||||||.||||||......|..... |. .|.|.......|| ||.|..|. 
vrkaleelpkg....gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnp
0040438 (Phosphotyrosine protein) phosphatases II 232-493 1.1e-81 269.9 In-house 16-262 (317) alignment 
Range on Protein: 232-493
Range on HMM: 16-262/317.0
GKAGFNEEFEQLQTMEHQhkfDRMEGARIENKSKNRYKNILPYDHTRVKLRNvPDGVIGADYINANFINGeaPGTDKAYIASQGTMPDTVADFWQMIVEQ
.. .. ||||.|... .    .. .... |||.||||..||||||.|||| . ..|. . |||||....|  |   ...|| || .|.||.|||.|. ||
dftalleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsp.lggdldsdYInAsyvdg..pnlkrkfIatqgPlpntvedFwrmvweq

NCRLVVMATNPVEKGKHKCTPYWPSseRRPARFGNYVVELLTEDNFDAYTVRRMSVAV-GEGDPREIYQYHYTSWPDHGVPP-EREFLQLIMKIRQHRDr
.....|| |...|.|. || .|||.  . .  .|...|.|| |.  . .|.|.. |   |....|.....|||.||||||||  ...|... ..|.... 
gvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.

lrksiPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGidcDIDIQSIIHKLRGQRSGMIQTA
     .. ||.|||||||.||||||......|......|   ..|.......|| ||.|..|| 
.....dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtp
subfamily_PTPRB_pd Subfamily PTPRB 232-496 4.4e-79 260.5 In-house 23-274 (293) alignment 
Range on Protein: 232-496
Range on HMM: 23-274/293.0
GKAGFNEEFEQLQTMEHQHKFDRMEgaRIENKSKNRYKNILPYDHTRVKLRNVPDgVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQ
 ...|.||.|.|........ .  |  . .|..||||.|||||||.|||| .. |   |.||||||.|.|    . . .||.|| .|.|| |||.|. |.
sdlrfseeyeelkavgkdqavkaae..lavnraknrytnilpydhsrvkLaalkd.esgsDYinanyipgyn..sprefiatqGPlpetvddfWrmvwek

NCRLVVMATNPVEKGKHKCTPYWPSSErRPARFGNYVVELLTEDNFDAYTVRRMSVAVgEGDPREIYQYHYTSWPDHGVPPERE-FLQLIMKIRQHrdrL
... .|| |. ||||| ||  |||. | .|  .|.  |.|..|.. . ...| ...   | . |.. |||.||||||||| . . .|... ..|..   .
kssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvrea...i

RKSiPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTAVCY
.|.    .|..||||||.||||||. .| .|. |..   .  .|| .|...|| .|  ..||   |
ekt.askrPivvhCsaGvGRtGtfialdrllqaiee...edyvdifgivaelReeRnllvqtekqY
subfamily_PTPRG_pd Subfamily PTPRG 232-493 1.6e-67 223.0 In-house 17-273 (563) alignment 
Range on Protein: 232-493
Range on HMM: 17-273/563.0
GKAGFNEEFEQLQTMEHQHKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQ
|. ||.||||.||.   ....|     . ||| |||| ||..||..||||...|.     ||||||.|.|      ||.||.|| ..||. |||.|| ||
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq..kskafiatqgplkdtfddFWrmiWeq

NCRLVVMATNPVEKGKHKCTPYWPSseRRPARFGNYVVELLTEDNFDAYTVRRMSVAV---GEG----DPREIYQYHYTSWPDHGVPPEREFlQLIMKIR
|  ..|| || ||.|..||  |||.    . ..|.  | | .|. .  ||||....      ..    . ....|||||.|||||||    . .||. ..
nvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslp.vLifvkk

QhrDRLRKsiPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTA
.  .. .|     ||..||||||.|||||..|.| .|  |..  .   ...  .....| ||  ..|| 
s..saank..aeaGPivvHcsaGvgrtGtyivldtllkqiqqena...vnvfgflkhiraqRnflvqte
subfamily_PTPN23_pd Subfamily PTPN23 232-494 2.1e-59 195.7 In-house 13-267 (288) alignment 
Range on Protein: 232-494
Range on HMM: 13-267/288.0
GKAGFNEEFEQLQTMEHQHKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDgvigaDYINANFINGEAPGTDkAYIASQGTMPDTVADFWQMIVEQ
||......|..|.. ....  .|   .   . .|||...||||||.|||||.  |     ||||| |... .||.   .||.|. .. |..|||.|..||
gktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskD.....DYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlmvyeq

NCRLVVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLTEDNFDAYTVRRMSVAVGEGD-PREIYQYHYTSWPDHGVPP-EREFLQLIMKIRQHRDR
  ...|| ... |.||.|.  |||... .. .||.. | |  . . . .  | ... . . |  ...   ..||||..|||    ..||.. ..... . 
kssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayea

LRKSIPGlgPTLVHCSAGIGRTGTFLVI-DIVLDLIRHYGIDcdiDIQSIIHKLRGQRSGMIQTAV
 ..      | .||||||.||||.| ..  .| .| .. |.    ||  ....|| ||  |.|.  
vqrkskt..PlvvhCsaGvgRtgvfalvyaavrelekgngll...diiqvvsrlreqRrfmvqeke
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 232-496 2.8e-59 195.6 In-house 22-268 (315) alignment 
Range on Protein: 232-496
Range on HMM: 22-268/315.0
GKAGFNEEFEQLQTMeHQHKFDRmeGARIENKSKNRYKNILPYDHTRVKLRnVPDGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQ
 | ||....| .    . | .|     .|||| |||| ||..||..||.|  . .   ..||.|||||.| .    . |||.||  . .| |||... |.
tkngfkqdyesipgg.qlhpldv..akkienkqknryiniiaydksrvqlp.llendphsdyvnanfidGyn..kkrryiaaqgpnvasvkdfwrlvfee

NCRLVVMATNPVEKGKHKCTPYWPSSerrPARFGNYVVELLTEDNFDAYTVRRMSVAVGEgDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRDrl
..  .|| || ||. |.|.  |||        .|.. | .  |. .. |||| .|| .|. . ||..|.||||||| |||     ...|| ...||..  
digkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgd.nirevvqlhytswpdmgvpkytiplmnlirtvkqhht..

rKSIpglGPTLVHCSAGIGRTGTFLVIDIVLDLIRhygIDCDIDIQSIIHKLRGQRSGMIQTAVCY
 .|.   |. .||||||.||||||. .| ||| .    ..  ||.  .|...| .| .|.|.|  |
.nsv...gaivvhcsaGvGrtGtfitldavldqae...aenaidvynfitgvrqnrikmvqvaeqy
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 232-495 3.9e-53 175.7 In-house 21-276 (325) alignment 
Range on Protein: 232-495
Range on HMM: 21-276/325.0
GKAGFNEEFEQLQTMEHQHKFDRMegaRIENKSKNRYKNILPYDHTRVKLRNVPDGViGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQ
 . ||  ||. | . . . |   |   . |||.|||.||....|..|| |    |    .|||||.... .     . ..|.|  ...|. |.|..... 
dqdgfahefgllpsddgiakkvam...kpenkaknrfknvvaldksrvvletkkddp.ssdyinasylrddk..kkdvflaaqaPltatindlWrlvldW

NCRlVVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLTEDNFDAYTVRRMSVA-VGEGDPREIYQYHYTSWPDHGVPPEREFLQLIMKIRQH-RDR
.|  ||. .| ...||..|. |||       .||   |.| | ...  |  |.. |  | .|. | . |... ||.| ||.     |  |... ..  .|
rcs.vvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavser

LRKSIPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTAVC
..    . .| |||||||.||||.|. .  .|. . .   .  .||   ..||| .|  |..|.  
vtantkastpilvhcsaGvGrtGvfislysalakvie...esrvdifgfvkklrkdrpsmvetvdq
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 233-493 1.5e-63 209.8 In-house 21-269 (305) alignment 
Range on Protein: 233-493
Range on HMM: 21-269/305.0
KAGFNEEFEQLQTMEHQHKFDRMEgariENKSKNRYKNILPYDHTRVKLRNVPDGViGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQN
. |.......|.. |.. . .. |    .||.|||.|.| ..|. |..|.. ..    .|||||....|      |.||..|| ...||||||..|||  
dkgleaqykslyeeeesidvgkke....ankaknrlkeitlldddriiltekesld.dsdyinasyvdgyk..rkkkyivaqgPlkntvadfWrliveek

CRLVVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLTEDNFDAYTVRRMSVAV--GEGDPREIYQYHYTSWPDHGVPPER-EFLQLIMKIRQHRDR
 . .|| |. || ||.||  ||| |.... .||...|||  | ..  |. |......  .. . | . ||. |.||||||| .   .|.|| ...... .
vstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk

LRKsipglGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTA
 ..      | |||||||.||||.|...|| |. ... ..   .|.  ....|| .| .|.|| 
dkg.....vpllVhCsagvgRtGvfiavdialerlkkEev...vdvfevlkqlRskrmkmvqtl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 233-496 5.6e-47 154.9 In-house 14-282 (301) alignment 
Range on Protein: 233-496
Range on HMM: 14-282/301.0
KAGFNEEFEQLQTMEHQHKfdrMEGARIENKSKNRYKNILPYDHTRVKLRNVPD-GVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQ
. .|.|....|...|...    . | . |||  ||.||| .||. |. |.. |.  .   .||||..|.|      |..||.|| |  |..|||..|...
snkfeeqykelkegedksc...tvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgys..ekkkfiaaqgpmkktlvdfWrliwqe

NCRLVVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLTEDNFDAYTVRRMSVAVGEGD----------------PREIYQYHYTSWPDHGV-PPER
    .|| ||  |. |.||. |||.|| .  .||.  |.|  | ..  ...|...| . .|                 .... |.. |.||..|| .  |
kpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrepr

EFLQLIMKIRqHrdrlRKSIPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTAVCY
  || | ..  |    |.  .| || .||||....|.|..  ..| |.  .  |.   .|.  ... .| .. |...|  .|
tvLqviddvi.h....rqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegV...VdvfqvtkavrrskpgaVtTLeqy
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 233-494 8.4e-37 121.5 In-house 19-223 (392) alignment 
Range on Protein: 233-494
Range on HMM: 19-223/392.0
KAGFNEEFEQLQTMEhqhKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVpDGVIGADYINANFINGEapGTDKAYIASQGTMPDTVADFWQMIVEQN
 | | ||| .|   .    ...  . .  |. ||||||||||| .||||  . | .   ||.|| .|..    ..||||||||  . .. |||.|. ..|
salffeefhdlpgpd...iypqtvaqkeinlkknryknilpydsarvklevi.ddipdsdylnasyipsf..dnekayiasqgpnaaslddfwrmvfqen

CRLVVMATNPVEKGkhkctpywpsserrparfgnyvvelltednfdaytvrrmsvavGEGDPREIYQYHYTSWPDHGVPPERE-FLQLIMKIRQHRDRLR
   ..| |.  |                                                | | . |.|.| |||..||     .|..| ... .  .  
vttiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyt

KsipglgPTLVHCSAGIGRTGTFLVIDIVLDlirHYGIDCDIDIQSIIHKLRGQRSGMIQTAV
.      | ..|||||.||||  . || |.    |      .|.  .. ..| .|  |.||  
h......pliihcsagvgrtgvvisidsvva...hakktrmvdvfnfvtnirrkrpymvqtke
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 233-493 8.5e-32 105.2 In-house 5-245 (267) alignment 
Range on Protein: 233-493
Range on HMM: 5-245/267.0
KAGFNEEFEQLQTMEHQHKFdRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDGvigadYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQN
.  ...|||... . ...          .|. .||. . ||||.||| ||.  .      |||| ...|    | .|.|. |...  |..||...| .|.
eceiekefelikkisdtsst.isqsiaeknqernrlddnlpyddtrvilrtkeee.....yinasyvegyk..tknafivtqdplkntitdfltvihdqk

CRLVVMATNpVekGKHKCTPYWPSSERRPARFGNYVVELLTEDNFDAYTVRRMSVAVGEGDPREIYQYHYTSWPDHGvpPEREFLQLIMKIRQhRDRLRK
.  .|. |. |  .. .   .||    .  .. . .||   | . . | .  . . . .   ...  |.|  |       .. .|. .. |   ...| .
vpvivlltk.v..ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnint..nnkpylkplfgila.knqlen

sipGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTA
   |  | .|.||.|.||.|||||||  |. ... |.    ||   . |.| || |...| 
...gnrPlvvacsdGvGrsGtflvidsqleraktegv...sdifdflrkirsqriglvdtk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 234-496 1.3e-60 200.4 In-house 34-280 (319) alignment 
Range on Protein: 234-496
Range on HMM: 34-280/319.0
AGFNEEFEQLQTMEHqhKFDRMEGARI-ENKSKNRYKNILPYDHTRVKLRNVpDGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQN
  .. || ..  .    .   .. | . .|| |||. |||..|...|||... .|. ..||||| |..|      . |||.|| ...|.||||.|| |.|
tklevefrracklgv..nladqtfanldqnkdknriinilafdknvvklerl.iGeefsdyinasfvtGyq..rkdkyiaaqGPldntladfWrmiweyn

CRLVVMATnpvekgKHKCTPYWPSSERRPARFGNYVVELLTEDNFdaYTVRRMSVAV--GEGDPREIYQYHYTSWPDHGVPPER-EFLQLIMKIRQhrdr
|  .|. |      |.||. |||         ..  |....| .   |.|| . ..    | | |.| |.|.  |||.|||    ....|. |.|     
cstivllt......kdkcsqywplkivikeerfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrh....

LRKSIPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTAVCY
|..   .  . .||||||.||||...|.|..|| ...   .  .|.  ... || ||. ..|  | |
ltskenhranivvhcsaGvGrtGvyivldvlldrmke...ekqvdvynfvrdlrqqrntlvqdlvqy
subfamily_PTPRK_pd Subfamily PTPRK 234-493 3.3e-59 195.3 In-house 22-263 (314) alignment 
Range on Protein: 234-493
Range on HMM: 22-263/314.0
AGFNEEFEQLQTMehqhkFDRMegARIENKSKNRYKNILPYDHTRVKLRNVpDGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQNC
 ||.||.| |        .|     . ||..|||...||.||..||.|  . ||   .|||||..|..      .|.|. || ...||.|||... ..||
ygfkeeyeslfeg.....wdaa..kkdenreknrsgdilaydrsrvfliti.dgdpssdyinaalidsyk..rpaafivtqgPlqetvkdfWrlvydenc

RLVVMATNPVEKGKHKCTPYWPSSERRparFGNYVVELLTEDNFDAYTVRRMSVAV---GEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRDR
  .|| |. ||.|. ||. |||   .    .|.  |||.  .    . || ..|     |  . ||. |.....||||.|| . . .|.|. .. .... 
asivmltelvevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee

lrksipGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTA
      . |...|||||| ||||||..||||||.|.. |.   .|.  ....|| ... |..| 
......eaGrivvhCsaGaGrtGtfiaidivldmieregv...vdvfnavktlrsrkvnmvete
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 234-493 3.3e-55 182.1 In-house 19-263 (315) alignment 
Range on Protein: 234-493
Range on HMM: 19-263/315.0
AGFNEEFEQLQTMEHqhkFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVpDGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQNC
| |.||| .|   .    . .  .   .| .|||||||||.|..||||  . |     ||||| .|..    .|||||||||  . .| |||.|..... 
alfseefhdlpdPdi...yrqrvaretinfkknryknilPldsarvklevi.ddsPdsdyinasyiksvd..ddkayiasqgPlkasvddfwrmvlqekv

RLVVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLTEDNFDAYTVRRMsVAVGEGDPREIYQYHYTSWPDHGVPPERE-FLQLIMKIRQHRDRLRK
  .|| |.  |  | ||  |||  .   ..||.. ||||  .     ..|.. |     . | . |...| |||.||. .   .|.|| ...  ...   
ttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkef

SIpglgptLVHCSAGIGRTGTFLVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTA
|.      |||||||.|||| .. || |.. |..      .|.  ....|| .|  ..|| 
sl......lvhcsaGvGrtGvvisidevvaqikr...trsvdvfnfvknlrakrpylvqte
0046845 (Phosphotyrosine protein) phosphatases II 235-494 3.4e-88 291.0 In-house 1-261 (284) alignment 
Range on Protein: 235-494
Range on HMM: 1-261/284.0
GFNEEFEQLQTMEHQHKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDGVIGADYINANFINGEAP---GTDKAYIASQGTMPDTVADFWQMIVEQ
|. ||||.|. . . . ...  ... ||.||||||.||||||.||||....... . |||||....|       . |..|| || .|.||.|||.|. ||
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

NCRLVVMATNPVEKGKHKCTPYWPSSeRRPARFGNYVVELLTEDNFDAYTVRRMSVAVG--EGDPREIYQYHYTSWPDHGVPP-EREFLQLIMKIRQHRD
|.|..|| |..||.|. || .|||..   . ..|.. |.|| |...| ||||....     .| .|.....||||||||||||  . .|... ..|....
nvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

RlrksIPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIDCDIDIQSIIHKLRGQRSGMIQTAV
.    .|| ||..||||||.||||||...|..|..... |... .|.......|| || ||.||  
n....lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle
subfamily_PTPRA_pd Subfamily PTPRA 235-496 3.3e-63 208.5 In-house 33-284 (330) alignment 
Range on Protein: 235-496
Range on HMM: 33-284/330.0
GFNEEFEQLQTMEHQHKFDRMegARIENKSKNRYKNILPYDHTRVKLRNVpDGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQNCR
 | |||. | . . |  ..    .. ||| |||. ||||||..|| | .. .||  .||||| ||.|      . .||.||   .|| |||.|| ||.  
lfreefnalPagpiqatlela..skeenkeknrvvnilPydfsrvilsvk.eGveesdyinasfidGyk..ekdkfiaaqGPkeetvedfwrmiweqksa

LVVMATNPVEKGKHKCTPYWPSSERrpARFGNYVVELLTEDNFDAYTVRRMSVA-VG----EGDPREIYQYHYTSWPDHGVPPER-EFLQLIMKIRQHRD
 .|| |.  |. ..||. |||.       .||  ||.  |    .|||| . |  ..    | ..| . |.|.||||| ||| |    |.|. |... ..
tivmltelkerkeekcaqywPdeGl..vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnq

RLRksipGlgPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTAVCY
.      |  |  ||||||.||||||.|.| ||. ..  ..   .|.  ....|| ||. |.||   |
qsa....g..pivvhcsaGvGrtGtfivldavlervkaerk...vdvfefvkrlrlqrpqmvqtdeqy
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 235-494 2.3e-48 159.7 In-house 21-266 (439) alignment 
Range on Protein: 235-494
Range on HMM: 21-266/439.0
GFNEEFEQLQTMEHQHKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPdGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQNCR
 |.|.||...... ... .    |.  ...|||||.. ..||||| |...| ||  . |||||.|.|    .|| |||.||   .|. |||....|... 
ifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeip.gvphshyinanyikGyy..ddklyiatqgpkkettddfwrlviekktv

LVVMATNPVEKGKhkctpYWPSSERrpARFGNYVVELLTEDNFDAYTVRRMSVAVGE---GDPREIYQYHYTSWPDHGVPPEREFLQLIMK-IRQHRDRl
 .|| || ||  |     ||||..   . .|. .|    . ..  |..| . |          | . |.||..|||. || .  ..   .. |    |. 
tivmltnlvesyk.....ywpsdae..vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandk.

rKsipGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRhygIDCDIDIQSIIHKLRGQRSGMIQTAV
 .     || .||||||.||||| . .|| |. ..   ..  .||. |.. || ||  |.|. .
.e...eygpvvvhcsagvGrtGtiialdialeqlk...lenkvdikgivkvlrkqrkqmvqalc
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 235-493 1.5e-38 127.4 In-house 7-252 (283) alignment 
Range on Protein: 235-493
Range on HMM: 7-252/283.0
GFNEEFEQLQTMEHQHKFDRMEGARiENKSKNRYKNILPYDHTRVKLRNVPDgvigaDYINANFIN-GEAPGTDKAYIASQGTMPDTVADFWQMIVEQNC
...  .|.|. .   ..   .. |. ||| |||...|.|.|  ||.|.. .      ||||| ||   .    || ||..|. . .|| |||.|. ... 
nnklfrevlkrlsvpdldadiasad.enkrknrnqeivpadqwrvelksesr.....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdeki

RLVVMATNPVEKGKHKCTPYWPSseRRPARFGNYVVELLTEDNFDAYTVRRMSVAVGEGDPRE--IYQYHYTSWPDHGVPPEREFLQLIMKIRQHRDRLR
  .|| |.  |  . ||. |||.  |    .|.. | |  |   ...... . . |      .  .  | .  | . |  .  . |  . |..  . . .
taivmltklqedlrikCsqyWPk..rGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqtesk

KsipglGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTA
|     || .||||.|||||..|. .   .. ..   .   .|. .... .| || ...|| 
k.....gPivvhCstgiGrtavfiaasasvkdaltesv...vdvfavvkimreqrmmavqtl
DSPc_SM00195 236-494 6.9e-82 270.1 In-house 2-249 (263) alignment 
Range on Protein: 236-494
Range on HMM: 2-249/263.0
FNEEFEQLQTMEHQHkfDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDGvIGADYINANFINGEapGTDKAYIASQGTMPDTVADFWQMIVEQNCRL
..||||.|.......  .  |... .|||||||||||||||||||| . ..   | ||||||.|.|.    .|.||| || .|.||.|||.|..|.....
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvki

VVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLTEDNFD-AYTVRRMSVAVGEG-DPREIYQYHYTSWPDHGVP-PEREFLQLIMKIRQHRDRLrk
.|| |...|.|| ||. |||... .. .||.. |.|  ... .  ...| ...   .  ..|...||.|..|||||||  ....|.|. ........   
ivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..

sipgLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTAV
     ||..||||||.||||||..|||.|. ....     .||..|. .|| || ||.||  
....sgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtle
PTPc_SM00194 236-494 6.9e-82 270.1 In-house 2-249 (263) alignment 
Range on Protein: 236-494
Range on HMM: 2-249/263.0
FNEEFEQLQTMEHQHkfDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDGvIGADYINANFINGEapGTDKAYIASQGTMPDTVADFWQMIVEQNCRL
..||||.|.......  .  |... .|||||||||||||||||||| . ..   | ||||||.|.|.    .|.||| || .|.||.|||.|..|.....
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvki

VVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLTEDNFD-AYTVRRMSVAVGEG-DPREIYQYHYTSWPDHGVP-PEREFLQLIMKIRQHRDRLrk
.|| |...|.|| ||. |||... .. .||.. |.|  ... .  ...| ...   .  ..|...||.|..|||||||  ....|.|. ........   
ivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..

sipgLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTAV
     ||..||||||.||||||..|||.|. ....     .||..|. .|| || ||.||  
....sgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtle
subfamily_PTPN13_pd Subfamily PTPN13 236-493 1.1e-69 229.7 In-house 13-255 (273) alignment 
Range on Protein: 236-493
Range on HMM: 13-255/273.0
FNEEFEQLQTMEHQHKFDrmEGARIENKSKNRYKNILPYDHTRVKLRNVPDgvigadYINANFINGEAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRL
 .|||..|. .  . . .  .| . |||.||||.|.||||.||||| .         ||||..|. .       |||.|| .|.||.|||||. ||....
Paeefkelrelkpldtce..vgkkkenkdknryrnvlPydetrvklgdegg......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaev

VVMATNPVEKGKHKCTPYWPSSERRPARFGN-YVVELLTEDNFDAYTVRRMSVAV-GEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRDrlrk
..| |. .|||| ||  |||.|....    | . ||||   . |...||.. |     |. ||. . ....||||||| .  |.||.....|. ..    
iamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt....

sipGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTA
     || .|||||||||.||...||.||.|| .   | ..|.. |..||| || |..|| 
...dagPivvhcsaGiGrsGtlitidvvlglier...dkefdvkeivrklreqrqgvvqtk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 236-496 1.2e-59 196.5 In-house 12-266 (287) alignment 
Range on Protein: 236-496
Range on HMM: 12-266/287.0
FNEEFEQLQTMEHQHKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNvpDGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQNCRL
 ..|...|.   .   .   .   . . .|||| ..||.|.||| | .  .|  |.||||||.. .     |.|.||.|| .. || |||....|..   
vdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsa..egelGsdyinanyvasyt..ddeafiaaqgPiaatvrdfwravletrsas

VVMATNPVEKGKHKCTPYWPSSeRRPARFGNYVVELLTEDNFD-AYTVRRMSVAVGEGDP-REIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRDRLRk
|.. |  ||... ||  |||   ..| | | | | ||  |. .  |.|| . ..  |.   | . |... ||||....|    .........|| .  | 
vitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielar.

SIPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGidcDIDIQSIIHKLRGQRSGMIQTAVCY
.  . || .||...||||.|..| . ....     |    .|.  .. .|| .| ...|..| .
dasevGPlvvhddvGiGrsGillatlvlvsrledlG...rvdvaavvirlreyraalvqavvql
subfamily_PTPN14_pd Subfamily PTPN14 236-495 5e-58 191.5 In-house 25-284 (300) alignment 
Range on Protein: 236-495
Range on HMM: 25-284/300.0
FNEEFEQLQTMEHQHKFDrmEGARIENKSKNRYKNILPYDHTRVKLRNVPDGviGADYINANFINGEAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRL
   |.|... .... ...   ..  ||..|||.|..|||...||.|    .     .||||  |.    |... ||..|| .. || |||||. ||. .|
vfteyeripkkredalls..taklpenaeknrfkdvlPyednrvelsptken..stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvql

VVMATNPVEKGKHKCTPYWPSS--ERRPARFGNYVVELLTEDNFDAYTVRRMSVA-VGEGDPREIYQYHYTSWPDHGVPPER----EFLQLIMKIRQHRD
.|| |.  |.||.|.  |.|..  ... ..||.. |     .. |... . . .  .  .. |...   || |||||||..     ..|. .  .|.. .
ivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktn

RLRKSIPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTAVC
. ..|     | |||||||.||||  .. |...  . |   . .|||......|| ||  ..||   
seveskeskPPvlvhCsaGvGrtGvlilsdlliatleh...neeidikkvlarLreqrmllvqtlaq
subfamily_PTPRN_pd Subfamily PTPRN 236-493 8.3e-50 164.2 In-house 31-278 (297) alignment 
Range on Protein: 236-493
Range on HMM: 31-278/297.0
FNEEFEQLQTMEHQHKFDrMEGARIENKSKNRYKNILPYDHTRVKLRNVPDgVIGADYINANFINGEAPGtDKAYIASQGTMPDTVADFWQMIVEQNCRL
...|.| | . | . .     . . .| .|||.|..|||||.||||..  .     ||||| .|  . |    ||||.|| ...||||||||. || . .
lekewealcayeaepstk.evakaeknvkknrskavlpydhsrvklkeeas.aeksdyinasaildhdpr.apayiatqgplastvadfwqmvweqGvvv

VVMATNPVEKGKHKCTPYWPSSERrpARFGNYVVELLTEDNF-DAYTVRRMSV-AVGEGDPREIYQYHYTSWPDHGVPPEREFLqliMkirQHRDRLRKS
.|. |.  |.| ..|. |||      . .. | |.|..|  . | | || . .  .   . | . |.|. |||..|||..   |   .   . | .. ||
ivnltrleeegvkqckrywpdeGs..evyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksl...l...efrrkvnks

IPGL-GPTLVHCSAGIGRTGTFLVIDIVLDLIRHyGIDcDIDIQSIIHKLRGQRSGMIQTA
  |   | .||||.| ||||....||.||. . . |.  .||| . . .|| ||.|...| 
yrGrscpivvhcsdGaGrtGvyilidlvlnrllk.Gvk.eidiaatlehlrdqrpglvktk
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 236-358 3.8e-07 23.2 In-house 5-88 (169) alignment 
Range on Protein: 236-358
Range on HMM: 5-88/169.0
FNEEFEQLQTMEHQHKfdrmEGARIENKSKNRYKNILPYDHTRVKLRNVPDGvIGADYINAnfingeapgtdkayiasqgtmpdtvadfwQMIVEQNCRL
.||  | ..|.|..            |..|||    |   ||||||. | .  .|.|||||                             .|| | |  .
ynelkefmktieynnf....maeltcnetknrpagplapshtrvklqrvmed.lgsdyina.............................rmiwetnasv

VVMATNPVEKGKhkctpYWPSSE
.|.  .  .|       .||  |
ivvlgdtddknn.....fwpeke
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 236-358 5.5e-07 22.6 In-house 4-87 (169) alignment 
Range on Protein: 236-358
Range on HMM: 4-87/169.0
FNEEFEQLQTMEHQHKfdrmEGARIENKSKNRYKNILPYDHTRVKLRNVPDGvIGADYINAnfingeapgtdkayiasqgtmpdtvadfwQMIVEQNCRL
.||  | ..|.|..            |..|||    |   ||||||. | .  .|.|||||                             .|| | |  .
ynelkefmktieynnf....maeltcnetknrpagplapshtrvklqrvmed.lgsdyina.............................rmiwetnasv

VVMATNPVEKGKhkctpYWPSSE
.|.  .  .|       .||  |
ivvlGdtddknn.....fwpeke
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 238-302 9.3e-09 29.3 In-house 17-77 (244) alignment 
Range on Protein: 238-302
Range on HMM: 17-77/244.0
EEFEQLqtMEHQHKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPdgVIGADYINANFINGE
|||  |   .| ..| . .     | .|||| ||||.|.||| | .      |.||||||.|.| 
eefvgl..sdhtreflqtnavlsanatknryinilpfdetrvilsssk..kegsdyinanyiqgs
subfamily_egg_pd Subfamily egg 239-496 3.3e-24 80.1 In-house 19-259 (307) alignment 
Range on Protein: 239-496
Range on HMM: 19-259/307.0
EFEQLQTMEHQHKFDRmeGARIENKSKNRYKNILPYDHTRVKLrNVPDGVIGADYINANFINGEaPGTdKAYIASQGTMPDTVADFWQMIVEQNCRLVVM
 .| |. . ..  . .   |  .|. | | | .   | .|||| ... |    |.| || ..|. |     .| .|  . .|| |||.|. ..... .||
rlevleesvdeisltt..aasdnnlekarskrvhckdssrvkl.elrrGqylddfihanrvkGk.pll.nefilaqaplkntvddfwrmvfqeevqyivm

ATNPVEKgkHKCTPYWPSSERRPARF--GNYVVELLTEDNF-D-AYTVRRMSVaVGeGDPREIYQYHYTsWPDHGVPPEREFLQLIMKIRQHRDrlrksi
 |  .|   ..|  ||| .|  ....  |.. .| |  |.  |  ..| .. . || ||  | .  |.  .  . .      |... |.|.         
ltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vG.gddeerflehwq.gdvnnssdvysplrvlrklrnlsk......

pglgPTLVHCSAGIGRTGTFLVIDIV-LDLIRHygIDCDIDIQSIIHKLRGQRSGMIQTAVCY
    |..|..  |. ...|.. |.|  |.|.|         ..  .  || .|   ..... |
....pvvvqdilGvskaatlvaieiallsllrG..pitkslvlravvflrlrrrlsvesvlly
subfamily_PTPN1_pd Subfamily PTPN1 247-493 2e-64 212.1 In-house 17-257 (290) alignment 
Range on Protein: 247-493
Range on HMM: 17-257/290.0
EHQHKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDgvigaDYINANFINgeAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKG
.. ..|.  |  . ||...|||... ||||.|.||..        |||||....  ..  .. || .|| .|.||. ||||. ||... |||  . |||.
keasdfptreaklpenrnlnryrdvspydhsrikleradn.....dyinaslve..leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvveke

KHKCTPYWPSSER-RPARFG--NYVVELLTEDNFDAYTVRRMSVAV-GEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRdRLRksiPGLGPTL
. ||. |||. |. .   .   .. |.|..|.. . |||| . .      . |||...|||.||| |||     ||....|.|.    |    .  ||..
qikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresG.sls...sdvGpav

VHCSAGIGRTGTFLVIDIVLDLIRHYGIDCDIDIQSIIHKLRGQRSGMIQTA
.||||||||.||| ..| .| || ...    .||.  . .|| .| |.||||
ihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqta
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 248-496 8.8e-34 111.5 In-house 42-278 (305) alignment 
Range on Protein: 248-496
Range on HMM: 42-278/305.0
HQHKFDRMEGARIeNKSKNRYKNILPYDHTRVKLRNVPdgviGADYINANFINGeAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGK
 |  |.  . | | ...||||...   |.. ||| . .     .||| ||..       .| .|..|| . .|. .|| |.....   .||  . || ||
tqvafnanqsadi.aitknryqdvpcqdqsavkldkps....psdyihanyvgc.pmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgk

HKCTPYWPSS--ERRPARFGnYVVELLT-EDNFD---AYTVRRMSVAVGEGDPREIYQYHYTSWPDHGVPPER-EFLQLIMKIRQHRdrlrksIpglgPT
 ||. ||| .  |..  . |  ||| ..    ..      .  . ..   ..   . . ..| ||| |||| .   |.|.  ||  .      .    | 
lkcaqywpaaqgeklelksg.ivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk......v....pi

LVHCSAGIGRTGTFLVIDIVLDLIRHYgIDCDiDIQSIIHKLRGQRSGMIQTAVCY
.|||||||||||| . |. .|. |     .|   .  ... || ||.  ||. | |
vvhcsagigrtgtivaieyilekiaen.kpcp.pmpelvkalrdqrafsiqndvqy
subfamily_eak_pd Subfamily eak 248-492 2.4e-21 70.5 In-house 38-290 (332) alignment 
Range on Protein: 248-492
Range on HMM: 38-290/332.0
HQHKFDRMEGARIENKSKNrYKNILPYDHTRVKLRNVPDGVIGadYINANFIngEAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGK
.|.     |.||.|.  .|   .|.|||.  |.| .      |  ||||  .  | .   . || .  .  | |  ||||..||.   .|.  . ||.. 
yqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlG..yinasla..efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkl

HKCTPYWPSSERRPARFGNYVVELLTEDNFDAYTVRRMSVAVGEgDPREIYQYHYTSWPDHGVPPEREFLQLI--MK-----------IRQHRDRLRKSI
 |   |.|   |   .|| . ||     . . . .| . . .|. .  ... |..  | .  .|  ..|| |   ||               .  |.| |
eksdkyfpdktreelkfGildverkefvkrniletrllelskGn.ethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyi

--PGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYgIDCDIDIQSIIHKLRGQRSGMIQT
  |     .. .. |  |.|.|.|||... ||    .     .. .| | . .|   . .
htppsfapiiqsarGsaraGvfvvidllirlidnk.kknlysvedlilkvkskrihsvlv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 248-493 2.2e-20 67.3 In-house 22-274 (302) alignment 
Range on Protein: 248-493
Range on HMM: 22-274/302.0
HQHKFDRMEGARIENK-SKNRYKNILPYDHTRVKLRNVPDGVIGADYI---NANFI--NGEAPGTDKAYIASQG-TMP--DTVADFWQMIVEQNCRLVVM
  .| ... .. .|.. |. | .  . . .|  || . ..  | |. .   . ..|  .|   ||.|    |.  ..|  .|.  .| .| . |  .|| 
aleklkkktstnlekdiserrkslficepktmaklvdfkndfinanvlkldeikwimaqGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvq

ATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLT----------EDNFDAYTVRRMSVAVGEGDPREIYQYHYTSWPDHGVPPEREFlqlIMKIRQHRD
 .. ||....||..|.    .   .||.| |. .             .|  |||      . .  .. .   ....||||| | | .     ..| .. .
lcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeayt...aldilkfce

RLRKSIpglgptLVHCSAGIGRTGTFLVIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTA
  .|..      |||||||.|||||.. |   ..|  .  .    |. ||.  .|  | | .|..
sykknv......lvhcsaGvGrtGtlvaikyGiqlcskkkv...tdllsivlpvrqcryGavqde
subfamily_ptpA1_pd Subfamily ptpA1 249-469 1.7e-47 157.1 In-house 34-261 (418) alignment 
Range on Protein: 249-469
Range on HMM: 34-261/418.0
QHKFDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDGvIGADYINANFINGEAPgtdKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKH
    .  || .  | ||||| |||| .||||.|... |   |.||||||.|.|  |   | .|..|| .|.|.||||.|. |. ||..|| .   |. . 
vgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdk.egsdyinanyidgayp...kqfictqgplpntiadfwrmvwenrcriivmlsresencri

KCTPYWPSS---E------RRPARFGNYVVELLT--EDNFDAYTVRRMSVaVGEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRDRLRKSIPG
||  |||     |           || | |||.   .|       | . .   ||. |.| ||.|  |||| .|   . | ||.  | ......  |   
kcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirl.tfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdr

LGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGI
  | .||||||.||||||    |..  . ||  
nvpiivhcsagvgrtgtfctavimmkkldhyfk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 252-496 5.1e-43 141.8 In-house 46-272 (290) alignment 
Range on Protein: 252-496
Range on HMM: 46-272/290.0
FDRMEGARIENKSKNRYKNILPYDHTRVKLRNVPDGvigaDYINANFINGeapgTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCT
..|    .  .  |||||..   | ||| |..  ||    ||. ||...|    ..  .| .||.. ||| |.|.|.....   .||  . .|.|| || 
lerkifdkntefkknrykdvvcndktrvilkdGydG....dyvhanyvkG....lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakce

PYWPSSERRPARFGNYVVELLTEDNFDAYTVRRMS-V-AVGEGDPREIYQYHYTSWPDHGVPPERefLQLIMKIRQhrdrLRKSiPglGPTLVHCSAGIG
.|.|  | .   ||.. |    ||. || .....  |  . .|    .. ..  ||||. |.     | |.  .|     |||  .  ||  ||||||||
qyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalst..lallrtlri....lrka.s..GpvvvhcsaGiG

RTGTFLVIDIVLDLIRHyGidCDIDIQSIIHKLRGQRSGMIQTAVCY
|||||  |.. |... . |   ..|.  ..  ||  | . .|  . |
rtGtfvaievglqilld.G..keldlldlvralrnsrlnsvqvdiqy
subfamily_CG7180_pd Subfamily CG7180 252-492 2.1e-42 139.8 In-house 32-275 (296) alignment 
Range on Protein: 252-492
Range on HMM: 32-275/296.0
FDRMEGARIENKSKNRYKNILPYDHTRVKLRNVpDGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKhKCT
 |   | | ||. |||. ...|||..|| |... ||    ||||| ....     .|.||  .. . .|| .||... ....  ||. |.. .  | .. 
gdCagglrkenreknrdvkvvPyDynRvvLekl.dGeeksdYinavyvdsfl..kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.myp

PYWPSSErrPARFGNYVVELLTEDNFDAYTVRRMSVAVG-----------EGDPREIYQYHYTSWPD-HGVPPE-REFLQLIMKIRQHRDRLrKSIPGLG
 |||      ...|. .||...|... . . | . .              . . | . ....| |.  . ||     ...|. ..|. |..  .  |  |
sywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv.dedpeeg

PTLVHCSAGIGRTGTFLVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQT
|..|..| | .|.| .| ||. |.|...   .  .|.   . .|| .| .....
PvvvvssdGasRsGvylaidanlelvek...eeevdvFeavktlrrsRpqLven
subfamily_PTPN3_pd Subfamily PTPN3 253-495 7.5e-67 220.2 In-house 32-263 (280) alignment 
Range on Protein: 253-495
Range on HMM: 32-263/280.0
DRMEGARIENKSKNRYKNILPYDHTRVKLRNVPdgvIgaDYINANFINGEAPGTDKA--YIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKC
.  .  . || |||||..|||||.|||||.. .      ||||||..| | |.|.    |||.|| ...|..|||||. ||...|.|| |. ||.|. ||
aisaarkpenlsknryrdilpydatrvklkese...t..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkC

TPYWPSSErRPARFGNYVVELLTEDNFDAYTVRRMSVAVGE-GDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRdrlrksIPGLGPTLVHCSAGI
  |||..|    ..|.. |..  ||.  .| .| . .   |  . |.| |  |..||||||| .  .||... ..|. |           |..|||||||
hqyWPete.deleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr......sgkeePvvvhCsaGi

GRTGTFLVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTAVC
|||| ...... | || .     .. .  |....| ||. ..|||  
grtGvlilletalaliea...aepvypldivrtmrdqramlvqtasq
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 254-494 3.2e-62 205.1 In-house 20-255 (274) alignment 
Range on Protein: 254-494
Range on HMM: 20-255/274.0
RMEGARIENKSKNRYKNILPYDHTRVKLRNVPDGVIGADYINANFINGEApGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPY
. |     ...|||||.||| ...|| |..       ..|||||.| |   ...|||.| || .| ||||||.|| .......|| |.  |. ..||. |
qeeldvfgsqtknryktilPnensrvllesessededssyinanyikGyd.eeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavy

WPSSERR--PARFGNYVVELLTEDNFDAYTVRRMSVAVGEGdPREIYQYHYTSWPDHGVPPER-EFLQLIMKIRQHRDRLRKSipgLGPTLVHCSAGIGR
.| .|      |.|.  ..     . . |.||....   |  .|... | ||.|||| .| .  ..|.|...... |..  .    |.|..|||||||||
fPdaedyeiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesreeenak...lapvvvhCsaGiGr

TGTFLVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTAV
|| |. |.| .  .|.   .  .|. .|. .|| .| ||.||. 
tGcfiaisiavrqlre...eivvdvlkivcnlrldrGGmvqtse
0045098 (Phosphotyrosine protein) phosphatases II 255-493 9.9e-75 246.8 In-house 26-258 (278) alignment 
Range on Protein: 255-493
Range on HMM: 26-258/278.0
MEGARIENKSKNRYKNILPYDHTRVKlrnvpdgvigaDYINANFINGEapgtDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYW
 .. ...|..|||||.||||||.|||           |||||..|.|     .|..|| || .|.||||||.|. |.... .||.|. ||.|. || .||
tpalylgnldknRykdilpydhsrVk...........dYINAsyidgy....pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

PSseRRPARFGNYVVELLTEDNFDAYTVRRMSVAV-----GEGDPREIYQYHYTSWPDHGVPPER---EFLQLIMKIRQHRDRLRKSI-------PGLGP
|.  . . ..|...|.|| |...| ||.|.. |        .. .|.....||..|||||||..     ||.|.  ||.....| . .       .. ||
pe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

TLVHCSAGIGRTGTFLVIDIVLDLIrhygiDCDIDIQSIIHKLRGQRSG-MIQTA
.|||||||.|||||. .....|.|.     .. .|.......|| || | ..|. 
vlVHCsaGvgRtGtlvaaylmlell.....eggvdlleavkelrsqRpglavqnl
0040439 (Phosphotyrosine protein) phosphatases II 255-493 5.2e-72 237.7 In-house 4-232 (249) alignment 
Range on Protein: 255-493
Range on HMM: 4-232/249.0
MEGARIENKSKNRYKNILPYDHTRVKLRNVPDgVIGADYINANFINGeaPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYW
 .. . |||.||||..||||||.||||  .|. . . |||||..|.|  .   ...|| || .|.||.|||.|. |.... .||.|..||.|. || .||
svallpenkdknrypdilpydhsrvklsilpg.lflsdyinAsyidg..yyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PSseRRPARFGNYVVELLTEDNFDAYTVRRMSVAV-GEGDPREIYQYHYTSWPDHGVP-PEREFLQLIMKIRQHRDRLrksiPGLGPTLVHCSAGIGRTG
|.  . .  .|...|.|| .. .| |||| . .   ..|..|......||.|||||||    ..|..| ..|.....|    |  ||.|||||||.||||
pl..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel....pkggpvlVHCsaGvgRtG

TFLVIDIVLDLIRHYgidCDIDIQSIIHKLRGQRSGMIQTA
||......|......   ...|.......|| ||.|..|. 
tfiaaylmleqleke...lgvdleeavkllrsqRpgavqnp
0049772 (Phosphotyrosine protein) phosphatases II 255-493 6.2e-43 143.1 In-house 39-266 (314) alignment 
Range on Protein: 255-493
Range on HMM: 39-266/314.0
MEGARIENKSKNRYKNILPYDhTRVKLRNVPdgVIGADYINANFINGEapgtdKAYIASQGTMPDTVADF----------WQMIV--EQNCRLVVM----
. .   .|..||||..|||.| .||.| ..|  | | |||||....|      ...||.|| .. || ||          |.|..  ..|.| .||    
lvadlflnrdknryldilpad.nrvilpglp..vsgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrde

-----------------ATNPVEKGkhkctpywpsSERRPARFGNYVvelltednfdayT-------VrrmsvavgegdPREIYQYHYTSWPDHGVPPER
                  ... ..|          .|  .|.. ..             .       .           .|....|... .||...|...
vladelsrLdaAlgKtpllildgng..........neptaadlellk............eelydpelf...........erlgikylripvpDgsaplle

EFLQLIMKIRQHrdrlrksiPGLGPTLVHCSAGIGRTGTFLVIDIvldLIRHYgidcDIDIQSIIHKLRGQRS-----GMIQTA
 |....  |...        .  ||.||||.||.||||||.|...   |....    ..... ... .| .|.     |.|.. 
dfdeflefieea........dkggpvlvHCkaGkgRtgtfvvaay...lmkll....gvsleealedvrlkRpinpnpgfieql
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 255-315 1.7e-09 31.7 In-house 41-95 (95) alignment 
Range on Protein: 255-315
Range on HMM: 41-95/95.0
MEGARIENKSKNRYKNILPYDHTRVKLRNVPDgvigADYINANFINGEApgTDKAYIASQG
  |.   |  |||. ||.||| ||| |    |    .||||| |..| |    ..|||.||
tvgsseanipknrflnifpydatrvvlttkrd....sdyinacfvdgya..rkncyiaaqg
subfamily_CG42327_pd Subfamily CG42327 257-423 3.2e-29 96.6 In-house 23-190 (319) alignment 
Range on Protein: 257-423
Range on HMM: 23-190/319.0
GARIENKSKNRYKNILPYDHTRVKLRNVPDGViGADYINANFINGEApGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPS
   .  | |.|. |..|  .||| |....|      |..|... |    ..  |||.| .. |. .|||... ||. | .| .|.. |.| ..|. |.|.
evPvtskdksrvinvvPlPetrvvlqrigddd.kdeyldasyvrGyd.dapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPt

SERRPA--RFGNYVVELLTEDNFDAYTVRRMSVA-VGEGDPREIYQYHYtSWPDHGVPPEREF-LQLIMKI
.|  .    .|.. | |   .  | | .  . .  | .   ||.  | |  |.. .|| | .  . .....
ketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllev
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 257-357 5.6e-27 89.4 In-house 42-153 (350) alignment 
Range on Protein: 257-357
Range on HMM: 42-153/350.0
GARIENKSKNRYKNILPYDHTRVKLR---NVPD----GVIGADYINANFINGEAPGTD----KAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEK
   .|  .||||||||||.|.||||.   . .|     . . ||||||... . .. .      ||| |. .| || ||...|.. . ..... |. || 
seGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvel

GKHKCTPYWPSS
. .||  ||.  
nlekcyrYWqeg
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 257-495 4.8e-25 82.8 In-house 47-278 (310) alignment 
Range on Protein: 257-495
Range on HMM: 47-278/310.0
GARIENKSKNRYKNILPYDHTRVKLRNvpDGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPS
 |  ..  |||| ...  | .||||.   |     ||| ||... .     ...| ||| .  |. |||.|| .. .  ...  . .|.|. ||  ||||
eaykkymhknrysdvvcldtsrvklki..dksryedyihanyvktny..lrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps

SERRpARFGNYVVELLTE--DNFD----AYTVRRMSVAVGEgDPRE-----IYQYHYTSWPDHGVPPEREFlqlimkirQHRDRLRKSIPgLGPTLVHCS
       .|   |  |.|  ..|.    | |     | | | .| .     .   ..  ||| ||| |.             .||   .   || .||||
lgvt.etygcirvtnlsesseefeicnlavtfvpdnvpvde.qpanlkelrvslikwpnwpdrgvpdekch........tvpqrllaqvr.hgpcvvhcs

AGIGRTGTFLVIDIVLDLIRHyGidCDIDIQSIIHKLRGQRSGMIQTAVC
||..|... . ... .| ... |    .|.. .. .|. .|   ||| . 
agkdrlyvvvalklkidkldr.g..lkvdaeevktellksraiciqtelq
0042113 (Phosphotyrosine protein) phosphatases II 258-493 4.8e-72 237.6 In-house 5-229 (245) alignment 
Range on Protein: 258-493
Range on HMM: 5-229/245.0
ARIENKSKNRYKNILPYDHTRVKLRnVPDGVIGADYINANFINGeaPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSs
...|||.||||..|||||||||||  ...|  . |||||....|  .   . .||.|| .|.||.|||.|. |.... .|| |...|.|..|| .|||. 
llpenkdknrysdilpydhtrvkls.pdggdldsdyinasyvdg..yritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

eRRPARFGNYVVELLTEDNFDAYTVRRMSVAV-GEGDPREIYQYHYTSWPDHGVPP-EREFLQLIMKIRQHRDRlrksiPGLGPTLVHCSAGIGRTGTFL
 . . ..|...|.||.|...| |||| ..|   |.. .||...|||..|||||||.  . .|...  .|... .     .. ||.|||||||.||||||.
.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.....dsngpvlVHCsaGvgRtGtfi

VIDIVLDLIRHYgidCDIDIQSIIHKLRGQRSGMIQTA
.....|......   ...........|| ||.|..|| 
aaylmleqleke...lgvsleeavkelrsqRpgavqtp
0037934 (Phosphotyrosine protein) phosphatases II 258-493 1.9e-69 229.2 In-house 6-228 (243) alignment 
Range on Protein: 258-493
Range on HMM: 6-228/243.0
ARIENKSKNRYKNILPYDHTRVKLrnvpDGvigADYINANFINGEapgtDKaYIASQGTMPDTVAD----FWQMIVEQNCRLVVMATNPVEKGKHKCTPY
 ..||.|||||..||||||.||||    .|    ||||||.|..     .. .||.|| .|.||.|    ||.|. |.... .|| |..||.|. || .|
llpenlsknrysdilpydhsrvkl....eg...sdyinanliyvt....pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPsseR-RpaRFGNYVVELLTEDNFDAYTVRRMSVAV--GEGDPREIYQYHYTSWPDHGVPP-EREFLQLIMKIRQHRDRL-------RKsipglGPTLV
||        ..|...|.|| | ..| |||| ...     .. .|....|||..|||||||.    .|... ..|.. ..|       ..     ||.||
wp...gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg.....gpvlV

HCSAGIGRTGTFLVIDIVLDLIrhygidcDIDIQSIIHKLRGQRSG-MIQTA
|||||.|||||.......|.|.       ..|.......|| ||.| ..|| 
HCsaGvgRtGtliaaylmllll.......gvdleeavkllreqRpgkavqtp
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 258-494 2.5e-59 195.5 In-house 16-251 (270) alignment 
Range on Protein: 258-494
Range on HMM: 16-251/270.0
ARIENKSKNRYKNILPYDHTRVKLRNVPDGVIgADYINANFINGEApGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSS
. . .|  |||..|||  .|||.| .. .  . . |||||...|   | .|.|||..| .| |. .||.||.|.. . .||.|. .|||..||  |||..
eaargkklnRyadiLPsPatRvrleeleedsa.taYinAnyvrGfd.gekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpae

ERR--PARFGNYVVELLTEDNFDAYTVRRMSVAvGEGDPREIYQYHYTSWPDHGVPPERE-------FLQLIMKIRQHRDRLRKSipglGPTLVHCSAGI
  .    ..|.  |  |.| . . | ..|. .   .|. |..  ..|..|||||||.| .        |... ..|.....|.|.    .|.|||||||.
pkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldka....ePllvHcsaGv

GRTGTFLVIDIVLDLIRHYGidcDIDIQSIIHKLRGQRSGMIQTAV
|||||....||.. |. . .    .|. .||..|| .|  ..|. .
gRtGtlialDiavrlLeetk...kvdvlaiieelRkdRmalvqhpe
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 258-496 2.7e-35 116.8 In-house 37-266 (307) alignment 
Range on Protein: 258-496
Range on HMM: 37-266/307.0
ARIENKSKNRYKNILPYDHTRVKLRNvpDGvIGADYINANFInGEApGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSS
|   |  ||||...   |..|. ..   || . .||| ||.. | |    | .|..|| . .|. .|| |.....   |.|  . .| .| ||  |||  
afsantdknryqdvkcqdkgrivvkf..dg.lasdyihanyl.gia.ikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywple

ERRPARFGNY---------VVELLTEDNfDAYTVRRMSVAVGEGdPREIYQYHYTSWPDHGVPPER-EFLQLIMKIRQHRDrlrksipglgPTLVHCSAG
| .   ||.           .. |. |. |   |  . |  ...  | | .. .. |||.|||.     . |.  .| ...          | .||||||
egqklvfgeapntisvanlgakklapde.dlinvttlkvdwaqk.srtiqhlqwenwpdrgvpqinltainlleavrydtn..........pvvvhcsaG

IGRTGTFLVIDIVLDLIRhYGIDCdIDIQSIIHKLRGQRSGMIQTAVCY
.||.|| . | .| | .   ||.|  |.. ....|| ||   ||| . |
vGrsGtivaislvqdkmi.aGinc.kdmkklveelrsqrhyaiqteaqy
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 259-496 3.8e-56 185.1 In-house 6-231 (250) alignment 
Range on Protein: 259-496
Range on HMM: 6-231/250.0
RIENKSKNRYKNILPYDHTRVKLRNVPdGVIGADYINANFINGEApGTdKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHkCTPYWPSSE
. .|| |||| .|...|..|| | ..  |   .||||| |..|   .. ||.||.|| ...|. |||.|..|..   .|| || .|..|  .. |||  .
kpqnkeknryadiialdssrvvLekek.gdkesdyinasflhgyd.er.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek

rrPARFGNYVVELLTEDNFDAYTVRRMSVAV-GEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRDRLrksipGLGPTLVHCSAGIGRTGTFLV
  . ..|.  |.|| ...|  ||.|.. ..   . | | . |.|...||| ||| . .  |.|. |... ...      | .| .|.||||.||.|.|..
..aekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqa.....gnaPvivqCsaGvgrsGafia

IDIVLDLIRhygIDCDIDIQSIIHKLRGQRSGMIQTAVCY
|| ||. ..   ..  .|.  .|..|| .| .....   |
idavlerlk...kekvvdvfkvikvlrkdrphavesleqy
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 259-493 1.9e-50 166.7 In-house 45-270 (297) alignment 
Range on Protein: 259-493
Range on HMM: 45-270/297.0
RIENK---SKNRYKNILPYDHTRVKLRNVPDGvIGADYINANFINGEAPgtdkAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKhKCTPYWP
  |.|   .|.|||||||||  ||||. | |    .||.|| |..|        .|..|  |..||||||.|.....   .|| ..  |. | ||. ||.
vaekkvnfeksRYkniLPydssRvkLaivndd.pdsDyvnasfvkgnkh....rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs

SSERRParFGNYVVELLTEDNFDAYTVRRMSVAVGE-GDPREIYQYHYTSWPDHGVPPEREFLQLIMKIRQHRDRLRKSIPGlgPTLVHCSAGIGRTGTF
 .   .  ||. .|.||. ..   .  | ..|. |.    | . ||....|||. |. . .  .|.  | . |.   .   |  | ||||.||.|||| .
dkgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg..PllvhclaGvGrtgvl

LVIDIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTA
| || |.  ...   . ..||  ...||| .|  ..|| 
ltidsvvaeakr...ekevdifglvkklrqerpylvqtk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 259-495 4.5e-31 103.0 In-house 40-259 (288) alignment 
Range on Protein: 259-495
Range on HMM: 40-259/288.0
RIENKSKNRYKNILPYDHTRVKLRNVPDGvigadYINANFINgeAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSE
 |.| ...||.|.   | ||||| . ||      ||.|| .   .   ..  | .|  .  |.  .|.|..|.. . .|| .. .||||.|   |.||  
fianptrdryenlprcditrvklsddpdf.....yiaanvvs..sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl

RRPARFGNYVVElLTEDNFDAYTVRRMSVA--VGEGDPRE-IYQYHYTSWPDHGVPPEreFLQLiMKIRQHRDRLRKsipglgPTLVHCSAGIGRTGTFL
 . ||.| .      ... |   . ..|.     ||. .  . . |.  |.|.||| .  .|   ... .    |.|      | .||.|||.|||||. 
Gekarigrlctv.vkkkradidklvkvsllriskegeekvivkilhlleWdddgvPen..ylsp.lrllevlkslqk......PivvhssaGvGrtgtli

VIDIVLDLIRhygIDCDIDIQSIIHKLRGQRSGMIQTAVC
.| |.|. .|   .| .. |.|...||| .|   |||   
lilialeslr...lddflgirsllaklreerfkaiqtemq
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 259-356 1.9e-20 67.5 In-house 45-155 (349) alignment 
Range on Protein: 259-356
Range on HMM: 45-155/349.0
RIENKSKNRYKNILPYDHTRVKLRNVP-------------DGVIGADYINANFINGEAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEK
 .|  .|||||.||||.|.||||.. .             |. .  ||||||...     ..| ||| |  .| || ||...|. .. .||.  ..  |.
GvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkel

GKHKCTPYWPS
. .||  ||  
slekcdiywqe
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 260-490 1.2e-20 68.4 In-house 41-259 (312) alignment 
Range on Protein: 260-490
Range on HMM: 41-259/312.0
IENKSKNRYKNILPYDHTRVKLRNvpDGvigADYINANFINGeaPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSE-
.  |  ||| ||  .|  |  |    |      || |||..       . ....|| . .|.. |||. .   .  ... .  || | .||. |      
lkfkdlnrypniqcwdrgrftlag..de...nfyihanfvki..ctkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivg

---R-RPARFGNYVVEL-LTEDNFDAYTVRRMSVAVG-EGDPREIYQYHYTSWPDHGVPPEREFLQ-LIMKIRqhRDRlrKsipglgPTLVHCSAGIGRT
         . .|. |. .     |  | | . | |   |.   . .| ..||||||.|   .  . |.  ..  .|.  |      | . |||||.|||
fvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk..kdk..k......pviahcsagvgrt

GTFLVIDIVLDLIRHYGIDcdiDIQSIIHKLRGQRSGMI
||. .|. ..  .||   .   ... .   || .|.  .
gtlaliesmiaalrhprkq...nvkdsfvllrkdrarsv
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 260-459 6.2e-20 66.0 In-house 45-233 (303) alignment 
Range on Protein: 260-459
Range on HMM: 45-233/303.0
IENKSKNRYKNILPYDHTRVKLRNvpdgvigADYINANFINGEapgTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSS--
..|  |||. ...  ||..||| .       . || |.... .   ..|  | .|  .. | |||||||.||. . |..     |  |      .|    
vknmdknrfvdvicldhskvklsd.......ssyihasyleld...sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd

----ERRPARFGnyvvELLTEDNFDAYTVRRMSVAVGEGDpREIYQYHYTSWPDHGVPPEReFLQLIMKIRQHRDRLRKSIPGLgPTLVHCSAGIGRTGT
    | |  | |    |.   .  | .... .||. |.     .. .|| .||   .| .    ... .| | .  |||  ..  ||.    .| ||.||
flkfeersirvg....efkrvelgdgwvlkvlsvsngdyk.sflhvhhykawphnsipsdg.spkfvkqiwqlqsvlrkysdst.ptvymslsgcgragt

FLVIDI
| ... 
falfet
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 260-302 6.8e-10 32.8 In-house 45-86 (440) alignment 
Range on Protein: 260-302
Range on HMM: 45-86/440.0
IENKSKNRYKNILPYDHTRVKLRNVpDGVIGADYINANFINGE
 .|| ||||.||| |||.|| | .|  ||  .||||| .||| 
pnnkvknryrnilaydhsrvmleev.kgvpdsdyinasyingi
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 260-353 9.6e-07 22.6 In-house 32-120 (332) alignment 
Range on Protein: 260-353
Range on HMM: 32-120/332.0
IENKSKNRYKNILPYDHTRVKLRNvPDGVigADYINANFINGEApgTDKAYIASQGTMPDTV-ADFWQMIVEQNCRLVVMATNPVEKGKHKcTPY
..|   ||   .  .||.||.|    ||    |. ||....| .     ||| .|  . |     ||.|. |..  ....  .  || |.| .||
lnnmdmnriphlycfdhsrvelap.qdgk..ddfynaswvdgys..kksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk.apy
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 261-496 3e-59 195.9 In-house 24-244 (284) alignment 
Range on Protein: 261-496
Range on HMM: 24-244/284.0
ENKSKNRYKNILPYDHTRVKLRNVpDGVIGADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATnpvekgKHKCTPYWPSSERR
.|| |||. .||..|...|||... .|. ..||||| ||.|      . |||.|| ...|.||||.|| |.||  .|. |      |.||. |||     
qnkdknrighilafdknvvklerl.iGeefsdyinasfitGyq..rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

PARFGNYVVELLTEDNFdaYTVRRMSVAV--GEGDPREIYQYHYTSWPDHGVPPER-EFLQLIMKIRQhrdrLRKSIPGLGPTLVHCSAGIGRTGTFLVI
    ..  |....| .   |.|| . ..    | | |.| |.|.  |||.|||    ....|. |.|     |..   .  . .||||||.||||...|.
keerfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrh....ltskenhranivvhcsagvgrtgvyivl

DIVLDLIRHygiDCDIDIQSIIHKLRGQRSGMIQTAVCY
|..|| ...   .  .|.  ....|| ||. ..|  | |
dvlldrmke...ekqvdvynfvrdlrqqrntlvqdlvqy
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 261-493 3.6e-56 185.1 In-house 2-225 (237) alignment 
Range on Protein: 261-493
Range on HMM: 2-225/237.0
ENKSKNRYKNILPYDHTRVKLRNVPDGvigADYINANFINGeAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSErR
||| |||| ||  |||.|| |.    |   .|||||....|   || | |||.|| .  .  |||||. ...| ..|| |  .|. . ||  ||||.. .
enkiknrygnivaydhsrvvlkgagsg...sdyinatylkg.fdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.q

PARFGNYVVELLTEDNFDAYTVRRMSVAV--GEGDPREIYQYHYTSWPDHGVPPEREflqLIMKIRQHRDRLRKSIPGLGPTLVHCSAGIGRTGTFLVID
|| .| . | |  ...|  |||| . ...     . | |.||..|||||.||| .      ....|..     . ..  || ..|||||.|||| |||||
paaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqta...allrfrkniinrsphvsesgpwiihcsagvgrtgiflvid

IVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTA
 .|   .   .   .||   .. .  .|  .||| 
amlrqakekkv...vdiynyvysieedrpyiiqtk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 261-493 2e-54 179.5 In-house 42-262 (515) alignment 
Range on Protein: 261-493
Range on HMM: 42-262/515.0
ENKSKNRYKNILPYDHTRVKLRNVPDGvIGADYINANFINGEapGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERR
 | .||||||||||| .||||  . |     ||.|| .|..    .|||||||||  . .| |||......|   ..| |.  |  | ||. |||     
infkknryknilPydsvrvklevindn.Phsdyfnasyipsf..dndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgd

PARFGNYVVELLTEDNFDAYTVRRMSVAVGEGdPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRDRLRKSIpglgptLVHCSAGIGRTGTFLVIDI
  .||.. |||.. .     . |.. |  |.   | . |.|.| |||.|||.. . .|.|| ...  ....  ..      ..|||||.|||| .. || 
svkfGsikvelvsleactggikrkltvlkgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpl......iihcsaGvGrtGvvisids

VLDlirHYGIDCDIDIQSIIHKLRGQRSGMIQTA
|.    |      .|.  .....| .|  ..|| 
vva...hakttrmvdvfnfvtnirqkrpylvqtq
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 261-495 1.4e-49 163.5 In-house 7-229 (239) alignment 
Range on Protein: 261-495
Range on HMM: 7-229/239.0
ENKSKNRYKNILPYDHTRVKLRNVPDGViGADYINANFINgEAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSErr
 ||.|||| ||. |||.|| | .. .    .|||||...  .  |. |||||.||..  .  |||.|. ..   ..|| |  .|  |.||  ||| |   
vnkaknryanivtydhsrvvleklsndp.hsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst..

pARFGNYVVELLTEDNFDAYTVRRMSV-AVGEGDPREIYQYHYTSWPDHGVPperEFLQLIMKIRqhRDRLRKSIPGLGPTLVHCSAGIGRTGTFLVIDI
 ... |  | |   . |  | .| . .  ||. . | .||||.| |||.|||   ..   .. .|  |   . |.||  | ..|||||.||||.||||| 
.skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvp...qyatavlglr..rkitkdslpgarpwvihcsagvgrtgaflvida

VLdliRHYGIDCDIDIQSIIHKLRGQRSGMIQTAVC
.|   |.   .  .||   .. .| .|  |.||.  
ml...rqakkqktvdifnyvkairedrphmvqtseq
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 261-495 1.5e-49 163.3 In-house 6-228 (239) alignment 
Range on Protein: 261-495
Range on HMM: 6-228/239.0
ENKSKNRYKNILPYDHTRVKLRNVPDGViGADYINANFINgEAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSErr
 ||.|||| ||. |||.|| | .. .    .|||||...  .  |. |||||.||..  .  |||.|. ..   ..|| |  .|  |.||  ||| |   
vnkaknryanivtydhsrvvleklsndp.hsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst..

pARFGNYVVELLTEDNFDAYTVRRMSV-AVGEGDPREIYQYHYTSWPDHGVPperEFLQLIMKIRqhRDRLRKSIPGLGPTLVHCSAGIGRTGTFLVIDI
 ... |  | |   . |  | .| . .  ||. . | .||||.| |||.|||   ..   .. .|  |   . |.||  | ..|||||.||||.||||| 
.skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvp...qyatavlglr..rkitkdslpgarpwvihcsagvgrtgaflvida

VLdliRHYGIDCDIDIQSIIHKLRGQRSGMIQTAVC
.|   |.   .  .||   .. .| .|  |.||.  
ml...rqakkqktvdifnyvkairedrphmvqtseq
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 261-493 2.2e-48 159.6 In-house 32-281 (297) alignment 
Range on Protein: 261-493
Range on HMM: 32-281/297.0
ENKSKNRYKNILPYDHTRVKLRNVPDgviGADYINANFINGEAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERR
    ||||..|| .| |||||..|.    . |||||...      .|  || .|| . .|| |||....||. | .|| ..  | |..||.|||||..  
sslrknryrdilatddtrvkllrvit...erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe

PARFGNYVVELLT--EDNFDAYTVRRMSVAVGeGDPREIYQYHYTSWPDHGVPPERE----F--------------LQLIM----KIRQHRDRLRKSIPG
  . |..||| |.   |.||   .  . .     . | .    . |||||||| . |    |              | |.      .    . ||   | 
rlkagdvvveflsstsdefdrviltelqliyr.sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraempr

LGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIDcdiDIQSIIHKLRGQRSGMIQTA
  ..|||||||.||.|  .  |..|. .|.  |    |...|...|| ||. ..|| 
nayllvhcsaGvGrsGvvvlsdvilaklrkkrip...dvaailsilreqrarlvqtl
Y_phosphatase Protein-tyrosine phosphatase 262-494 1.9e-71 235.5 Pfam-A 1-224 (235) alignment 
Range on Protein: 262-494
Range on HMM: 1-224/235.0
NKSKNRYKNILPYDHTRVKLrnvpDGVIG-ADYINANFINGEApGtDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERR
||.|||||.|||||.|||||    .|  |  ||||||...|     .|..||.|| ...|..|||.|.........|| |. .|||. || .|||..|..
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee

PARFGNYVVELL-TED-NFDAYTVRRMSVAVGEGD--PREIYQYHYTSWPDHGVPP-EREFLQLIMKIRQHRdrlrksIPGLGPTLVHCSAGIGRTGTFL
. ..|.. |||   |  . ..||.| ...   ...  .||..|.|||.|||||||   ...|.|| |.....       .  ||..||||||.||||||.
sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvgRtgtfv

VIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTAV
..||.|. ... .    .|. .|. .|| || ||.|.. 
aldilleqleaeee...vdvlqivkelRkqRpgmvqsle
Y_phosphatase Protein-tyrosine phosphatase 262-494 1.9e-71 235.5 In-house 1-224 (235) alignment 
Range on Protein: 262-494
Range on HMM: 1-224/235.0
NKSKNRYKNILPYDHTRVKLrnvpDGVIG-ADYINANFINGEApGtDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERR
||.|||||.|||||.|||||    .|  |  ||||||...|     .|..||.|| ...|..|||.|.........|| |. .|||. || .|||..|..
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee

PARFGNYVVELL-TED-NFDAYTVRRMSVAVGEGD--PREIYQYHYTSWPDHGVPP-EREFLQLIMKIRQHRdrlrksIPGLGPTLVHCSAGIGRTGTFL
. ..|.. |||   |  . ..||.| ...   ...  .||..|.|||.|||||||   ...|.|| |.....       .  ||..||||||.||||||.
sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvgRtgtfv

VIDIVLDLIRHYGIdcdIDIQSIIHKLRGQRSGMIQTAV
..||.|. ... .    .|. .|. .|| || ||.|.. 
aldilleqleaeee...vdvlqivkelRkqRpgmvqsle
0041856 (Phosphotyrosine protein) phosphatases II 262-492 2.5e-48 159.4 In-house 1-156 (182) alignment 
Range on Protein: 262-492
Range on HMM: 1-156/182.0
NKSKNRYKNILPYDHTRvklrnvpdgviGADYINANFINGEAPGTDkaYIASQGTMPDTVADFWQMIVEQNCRLVVMATnpvekgkhkCTPYWPsserrp
|..||||..||||||.|           . ||||||.. |  |.|.  .|| || ...|||||..|. |......|..|         . .|||      
nldknrysdilpydhsr...........dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywp......

arfgnyvvelltednfdaytvrrmsvavgEGDPREIYQYHYTSWPDHGVPPEREFLQLIMKIRQhrdrlrksipGLGPTLVHCSAGIGRTGTFLVIDIVL
                             |  .|...||.|..|||||||. .|.|..| ....            ||.|||||||.|||||. ......
.............................ellerlgiqylylpwpDhgvpdldelldfieevle..........eggpvlVHCsaGvgRtgtlvaaylmk

DLirhygidcDIDIQSIIHKLRGQRSGMIQT
 |        ......... .| .|.||..|
kl........gvsleeavklvrsrRpgmvit
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 262-492 6.1e-33 108.7 In-house 37-254 (281) alignment 
Range on Protein: 262-492
Range on HMM: 37-254/281.0
NKSKNRYKNILPYDHTRVKLRN-VPDgVIGADYINANFINgeAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERR
|. |||| ||   | .||.|.  .|.    .||| ||.|   .|   . || .||   .| ||||.|| ..|   .||  . .|  . ||. |.|   . 
nnkknrylnipcldisrvqlkvkmpn.knstdyihanyir..spflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahc

PARFGNYVVELLTEDNFDAYTVRRMSVAVgEGDPREIYQYHYTSWPDHGVPPEREFLQLIMkiRQHRDRlrkSIpglgPTLVHCSAGIGRTGTFLVIDIV
  .| .. |.        .    |. ..  ||. | | .. .  |||  ||   | .  |.  |. | |   |     | ..|||||.||.||.. ..| 
clqfdklsvsyedstvnkslvttrlnlsy.egetrlithwlwkewpdwqvpessevmlkil..rkirar...st....ppvihcsagvgrsgtlmaveia

LDLIRHYGIDCdiDIQSIIHKLRG-QRSGMIQT
|. |. .      ||. |. .||   |.  .||
lqsihshftlp..dikqivshlrvtgraasvqt
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 262-493 4.1e-27 89.7 In-house 50-267 (301) alignment 
Range on Protein: 262-493
Range on HMM: 50-267/301.0
NKSKNRYKNILPYDHTRVKLrnVPDGVIGadYINANFINGEapGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERRP
.| |.||...    .| |..  . ||      | ||.|. .  |  . .||.|| ...|  ||| |.|  .   .|| .. ||| ..||. | |.. .. 
pkdkhryptvPckPstavev..ivdGkrv..Pihanwipts..GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisek

ARFGNYVVELLTEDNFDAYTV--RRMSVA--VGEGDPREIYQYHYTSWPDHGVPPEREFLQLIMKIRQHRDRlrksipglgPTLVHCSAGIGRTGTFLVI
 . | . ... ...      .  |.. |.   |. ..| .  | |..|.|.|||     |  .|.. .. ..         | .|||||||||. .|.  
ldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.........PivvhcsaGiGrsvafigt

DIvldLIRHYGIDCDIDIQSIIHKLRGQRSGMIQTA
..   | |.   |  |...  ...|| .|   .|| 
ey...lareveadptieltealkhlrehrwngvqtn
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 262-492 6.5e-25 82.6 In-house 35-255 (285) alignment 
Range on Protein: 262-492
Range on HMM: 35-255/285.0
NKSKNRYKNILPYDHTRVKLRNVpdgviGADYINANFINgeAPGTDK-AYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERR
|   ||| ..   . ||| |.|        ||| |...    || |. .||..|| .|.|..|||.|| ...   |.|    .| |  ||. |.|     
npdlnryadvrcieetrvvlknh.....drdyihaswmr..mpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

PARFGNYVVELLT--EDNFDAYTVRRMSVAVGEGDP-REIYQYH--YTSWPDHGVPPEREFLQLIMKirqhrdRLRKSIPGLGPTLVHCSAGIGRTGTFL
  .||.| . |    |.      .  ..|   |      .|  |     |||.  | .   .  . |       ..|  |   |  ||||||.||| ||.
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielyk......wvkkvnpkekpicvhcsagvgrtatfv

VIDIVLdlIRHYGiDCDIDIQSIIHKLRGQRSGMIQT
 ||     ||    . .|..  |....|  |   .|.
gidyat..irime.npniemldivremramrfqavqs
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 262-342 8e-08 26.2 In-house 37-119 (347) alignment 
Range on Protein: 262-342
Range on HMM: 37-119/347.0
NKSKNRYKNILPYDHTRVKLRNVPDGVIGA----DYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNP
. |||| |.    | ||| |         |     ||||  |. .   ..| || .|  .|||| |||.|.   .   ||   .|
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdn..askeyiltqyplpdtvrdfwkmvsvtkvtqvvtifep
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 264-494 2e-15 51.7 In-house 21-246 (290) alignment 
Range on Protein: 264-494
Range on HMM: 21-246/290.0
SKNRYKNILpYDHTRVKLRNVpDGVIGADYINANFINGeaPgTDKAYIASQ-------GTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKH----KCTP
 ..|... |   .||| |..     .  ||| ||..    |  . . |..|        .   |. .|| |. . . . |||  .  || ..     |. 
mdqRlevpL.veatrvvLkgy.gkrfnddyiHAnrvtc..p.nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCak

YWPSSERRPARFGNYVVELLTEDNFDAYTVRRMSVAVGEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRdrlrksipglGPTLVHCSAGIGRT
| | |.    .|..  |.     . |   .|.. |  ... .  .  . . .| .  |... . .|.||.|.....           | .|||  || | 
YvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkask..........tpvivHcvdGiSrs

GTFLVIDIVLDLIRHygIDCDIDIQSIIHKLRGQRSGMIQTAV
 ..  |..   .| .     .. .......|| ||  .|..| 
AalaaiilgyQkiae..tsgsvkledvlkalrkqralaitsal
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 272-386 5.9e-08 27.1 In-house 3-101 (130) alignment 
Range on Protein: 272-386
Range on HMM: 3-101/130.0
LPYDHTRVKlrnvpdgviGADYINANFINgeAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNpVEKGKHkctpYWPSSERRPARFGNYVVEL
|... .|..         | .||||.|.     |  . |. .| .. ||  |||.|..|.   ..|.    ||.       ||| ||       . .| |
lefevsrlq.........gntyinasfvG..llgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.veeede....ywpdsePlewyeediivtl

LTEDNFDAYTVRRMS
   |.|.      . 
tdrdefknikasnle
0044763 (Phosphotyrosine protein) phosphatases II 273-493 4.2e-34 113.1 In-house 1-157 (178) alignment 
Range on Protein: 273-493
Range on HMM: 1-157/178.0
PYDHTRVKLRNVpDGVIGADYINANFINGEapgtdkAYIASQGTmpdtvADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERrparfgnyvvell
|.|.|||.| |.  |. ..|||||..| .        |..|...     ||..... |......|. |...| |..|| ||||...              
pldrtrvllsnl.eglersdyinaseilpg......lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.............

tednfdaytvrrmsvavgegdpreiYQYHYTSWPDHGVPP-EREFLQLIMKIRQHRDRLRksipglGPTLVHCSAGIGRTGTFLVIDIVLDLirhygidc
                         .||... .||||||.  . ||...  |....|.        ||.|||||||.||.||. ...... |        
.........................iqylhipipDhgvpdllehflefvefieealdekg......gpvlVHCsaGvgRsgtlvaaylmkkl........

DIDIQSIIHKLRGQRSgMIQTA
.......|. .| .|. .... 
glsleeaielvrerRp.ivpnp
subfamily_hpo-7_pd Subfamily hpo-7 279-493 6.9e-16 52.9 In-house 9-213 (263) alignment 
Range on Protein: 279-493
Range on HMM: 9-213/263.0
VKLRNVPDGVIGADYInanfINGEAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELlTEDNFD
.|  ..|  .|  |       .. .|  ||   ...  . .|.. |.|.|| ..   ||| ..  |.|. ||  |.|       .. |  |   |.   |
lkfgklPrilidedvc....tehfkPekdkkrknlysllvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvct.tkvqsd

AY-TVRRMSVAVG-EGDPREIYQYHYTSWPDHGVPPE-REFLQlIMKIRqhRDRlrKSIpglgptLVHCSAGIGRTGTFLVIDIVLD-LIRHY--GIDCD
     . .   .|     ... .| |. |...  | . || |. |.|.   |.   ||.       ||||.||||.  | |...|   .||        .
vllktlellstlgeKkkthtvkhysykgWiekndpelareiln.ilkva..rns..ksl......vvhcstGiGrsaafsvaElvyqkmirsldttstve

IDIQSIIHKLRGQRSGMIQTA
.|  |....|| .|.. |.| 
ldylsLleelrssrkraihtP
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 280-493 1.7e-19 64.9 In-house 7-207 (255) alignment 
Range on Protein: 280-493
Range on HMM: 7-207/255.0
KLRNVPDGVIGADYINANFINGEAPGTDKAYIAsqgtmpdTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERRPARFGNYVVELLTEDNFDA
|  ..|  .|  |    ..     .   . |.        ||. |.|.|| ..   ||| ..  |.|. ||  |.|       .. .  |      .   
kfkklPrilidedvctehvkPekdkkrknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvv

YTVRRMSVAVG-EGDPREIYQYHYTSWPDHGVPPEREFLQLIMKIRqhRDRlrKSIpglgptLVHCSAGIGRTGTFLVIDIVLD-LIRHY--GIDCDIDI
   ...   .|     ...  |.|. |...  | . . .. |.|.   ||   ||.      .||||.||||. .| ....|   .||        ..| 
lrtleitstlgekkkthtvkhysykGWieknaPelareilnilkvv..rds..ksv......vvhCstGiGrsaafvlaelvyqkmirsldttetveldy

QSIIHKLRGQRSGMIQTA
 |....|| .|.. |.| 
lslleelrskrkraihtP
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 286-417 1.2e-09 32.1 In-house 117-242 (244) alignment 
Range on Protein: 286-417
Range on HMM: 117-242/244.0
DGVIGADYINANFINgeAPGTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATnPVEKGKHkctpYWPSSERRPARFGNYVVELLTEDNFDAYTVRRM
 | .|  |||| |.     |    || .|  . ||  |||.|..|.   ..|.    ||.       ||| ||       .  | |   |.|       .
kgsmgntyinasfvg..clgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlg.sveeede....ywpdseplewyeeditvtltdrdefknikasnl

SVAVGEGDPR-EIYQYHYTSWPDHGVPPEREFL
 .     .    .  .  . ||  |  |.  |.
eiesdmneshqaltmfqisnwpsdgttpndhfi
0046846 (Phosphotyrosine protein) phosphatases II 289-493 3e-39 129.9 In-house 10-159 (176) alignment 
Range on Protein: 289-493
Range on HMM: 10-159/176.0
IGADYINANFINGEApgtdkaYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERRPArfgnyvvelltednfdaytvrrmsva
 . ||||||.| | .      .|| || .|.|.|||..|. |.....||. |..||.|..||. |||  |.                             
ldldyinanlilgsr......piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

vgegdpreiyQYHYTSWPDHGVPPEREFLQLIMKIRQHRDRlrksipGlGPTLVHCSAGIGRTGTFLVIDivldLIRHygiDCDIDIQSIIHKLRGQRS-
          ||... |||||||. . .|.|.  ||.....      | ||.|||||||||||||.....    |...   ....... .....| ||. 
..........qylhlpwpDhgvpdlelllellefirealke......g.gpvlVHCsaGigRtgtlvaay....llel...ekglsveealalvreqRpl

GMIQTA
|..|| 
gavqtp
0051429 (Phosphotyrosine protein) phosphatases II 291-494 2.4e-44 147.3 In-house 4-212 (272) alignment 
Range on Protein: 291-494
Range on HMM: 4-212/272.0
ADYINANFINGEapGT---DKAYIASQGTMPDTVADFWQMiVEQNCRLVVMATNPVEKGKHKCTPYWP----------SSERRPARFGNYVVELLTEDNF
 .||||....|   |    ......|.| .| |.||||..  |.... .|. ....|.|..|| .|||          ...  . ..|...| || | ..
sgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

DAYTVRRMSVAV--GEGDPREIYQYHYTSWPDHGVPPEReFLQLIMKIRQhrdrlrksipgLGPTLVHCSAGIGRTGTFLVIDIVLdliRHYGIDCDID-
. |..|.. .    . |..||....|||.|||||||.|  .|.|.  ...            || |||||||..||||. .....|   .  . .. .| 
ldyilrellltlllsagearevmhlhytdwpdhgvpqea.llellellld...........ggpvlvHCsaGkdRTGtvvalllll...lgvsletivdd

-------IQSIIHKLRGQRSGMIQTAV
       .. ....|| || |..||  
Ylltnlyleeaveelraqrpgavqtee
0036282 (Phosphotyrosine protein) phosphatases II 291-492 4.8e-38 125.9 In-house 2-155 (174) alignment 
Range on Protein: 291-492
Range on HMM: 2-155/174.0
ADYINANFINGEAPGTdkAYIASQGTMPdtvadFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSserrparfgnyvvelltednfdaytvrrmsvaVG
 |||||.....    .   .||.|| ..     ||.|. |.... ||| ....|.|..||  |||.                                  
sdyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lr

EGDPREIYQYHYTSWPDHGVPPEREFLQLIMKIRQHRDRlrksiPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRhygiDCDIDIQSIIHKLRGQRSGMI
|   |...||.|. |||||||.  ..|...  ..... .     .. ||.|||||||.|||||. .....| ...       .|. .....|| ||.||.
edlerlgiqylylpwpDhgvpdlsillefvkfveealse.....dpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmv

QT
||
qt
0043147 (Phosphotyrosine protein) phosphatases II 291-493 1.1e-36 121.5 In-house 5-147 (172) alignment 
Range on Protein: 291-493
Range on HMM: 5-147/172.0
ADYINANFINGEApgTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPvekgkhkctpywpsserrparfgnyvvelltednfdaytvrrmsVAVG
 |||||.....      . .|| || .. |.||||.|. |......|..|.                                             .  .
sdyinasyldlyy..ipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp

EGDPREIYQYHYTSWPDHGVPPEREFLQLIMKIRQHR--DRlrksipgLGPTLVHCSAGIGRTGTFLVIDIVLdlirhygidCDIDIQSIIHKLRGQRSG
|.  |...||.|..|||||||. . .|...  |...   ..        ||.|||||||.|||||. .....|         ...... ... .| .|.|
ellerlgiqylylpwpDhgvpllellleflefidellalsp.......ggpvlVHCsaGvgRtgtlvaaylml.........lglsleeavalvrekRpg

MIQTA
..|. 
avqnp
0051082 (Phosphotyrosine protein) phosphatases II 291-493 4.7e-28 93.1 In-house 3-139 (151) alignment 
Range on Protein: 291-493
Range on HMM: 3-139/151.0
ADYINANFINGEapgtdkaYIASQGTMPdtvaDFWQMIVEQNCRLVVMATNPVEKGkhKCTPYWPSSErrparfgnyvvelltednfdaytvrrmsvavg
 ||||.... |        ...|.| ..    ||.... |.... .|. ....| |  .|. |.|. .                                
sdyinfsyvtgg.......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

egdpREIYQYHYTSWPDHGVPPEREFLQLIMKIRQHrdrlrksiPGLGPTLVHCSAGIGRTGTFLVIDIVLdlIRhygidcdIDIQSIIHKLRGQRSGMI
    .|........|||.|.|   .... .... ..        .. ||.|||||||.|||||. .....|   .       ........ .| .| |..
....ievlhipildwpdpglplsfdavleflellld........kkngpvlvHCsaGkgRTGtlvalylml..lg.......vsleealeeyrlkrpgvv

QTA
|. 
qpn
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 307-492 2.3e-21 70.9 In-house 3-188 (198) alignment 
Range on Protein: 307-492
Range on HMM: 3-188/198.0
DKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNpVEKGKH-KCTPYWPSSERRPARFGNYVVELLTEDNFDAYTVRRMSVAVGE---GDPREIYQYHY
.. |||.|  . .|.||||||. |     .||  .  .| |      |||..|   ...|.  |   |      ||.  . ..         ||| .| .
qrryiatqhplretladfwqmvwetgsghivmvnd.dqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TSWPDHGVPPEREFLQLIMKIRQHRDRLRKSIPglGPTLVHCSAGIGRTGTFLVIDIVLDLIRHyGIDCDIDIQSIIHKLRGQRSGMIQT
||| ..  |    |. ...  |.   .  .      | .|||| | | || |. .|| .           .|.  . ..||  | |.| .
tswkekttpnvalfvgfvvasrevskkyeqekd..apvivhcsdgqgftgvfvaldigvrshee.sktsvvdlfevakrlrqarcgiiss
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 307-492 2.4e-21 70.8 In-house 4-189 (199) alignment 
Range on Protein: 307-492
Range on HMM: 4-189/199.0
DKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNpVEKGKH-KCTPYWPSSERRPARFGNYVVELLTEDNFDAYTVRRMSVAVGE---GDPREIYQYHY
.. |||.|  . .|.||||||. |     .||  .  .| |      |||..|   ...|.  |   |      ||.  . ..         ||| .| .
qrryiatqhplretmadfwqmvwetgsghivmvnd.dqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TSWPDHGVPPEREFLQLIMKIRQHRDRLRKSIPglGPTLVHCSAGIGRTGTFLVIDIVLDLIRHyGIDCDIDIQSIIHKLRGQRSGMIQT
||| ..  |    |. ...  |.   .  .      | .|||| | | || |. .|| .           .|.  . ..||  | |.| .
tswkekttpnvalfvgfvvasrevskkyeqekd..apvivhcsdgqgftgvfvaldigvrshee.sktsvvdlfevakrlrqarcgiiss
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 307-386 3.1e-06 20.8 In-house 235-310 (440) alignment 
Range on Protein: 307-386
Range on HMM: 235-310/440.0
DKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKgkhKCTPYWPSSErRPARFGNYVVELLTEDNFDAYTVRRMS
 .|.||.|  .  || |||... . .   ..|  .  .|    |. |||    |   || . |     .|..   || . 
knafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvnt.rsvtfgpftvghkgsenmnrvkvrtle
0049260 (Phosphotyrosine protein) phosphatases II 308-493 8e-36 118.4 In-house 9-136 (152) alignment 
Range on Protein: 308-493
Range on HMM: 9-136/152.0
KAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWpsserrparfgnyvvelltednfdaytvrrmsvavgegdpreiyQYHYTSWPD
...|| ||..| |.||||.|. |.... .|| |...|.|| ||  |.                                            ||... |||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwpD

HGVPPEREFLQLIMKIRQHRdrlrkSIPGLGPTLVHCSAGIGRTGTFLVIDIVLdlirhygidCDIDIQSIIHKLRGQRSGMIQTA
||||.  ..|. .... ...      .   ||.|||||||.|||||. .....|         ...... ..  .| .|.|.... 
hgvpdlsqlllflllfiekl.....aldkggpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnp
0048076 (Phosphotyrosine protein) phosphatases II 353-493 4.4e-23 77.0 In-house 2-129 (145) alignment 
Range on Protein: 353-493
Range on HMM: 2-129/145.0
YWPSSERRPARFGNYVVE--LLTEDNFDAYTVRRMsVAVGEGDPREIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRDRlrksipGlGPTLVHCSAGIG
||||       .|.. .   | .  ... .|| ..     |.  |...||.|..|||||||.  . .|...  |......      | ||.|||||||.|
ywpseilpglylgslptaldlellkdlgittvlnl.tselellerlgiqylylpwpDhgvpdllellleflefieealke......g.gpvlVHCsaGvg

RTGTFLVIDIVLDlirhygidCDIDIQSIIHKLRGQRSGMIQTA
||||. .....|         ............| ||.|.... 
Rtgtlvaaylmll........lgvsleealelvrsqrpgavpnp
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 384-493 1.7e-13 45.0 In-house 204-330 (350) alignment 
Range on Protein: 384-493
Range on HMM: 204-330/350.0
RMSVAVGEGDPREIYQYHYTSWPDHGVPP-EREFLQLIM----KIRQHRDRLRKSIPGLGPTLVHCSAGIGRTGTFLVIDIVLD------LIRH--YGID
 ... .   || ..|| ..  |.| ..    ...|| .      | .   ..      . | |||||||.|||||.. .| .|        ...    .|
ltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkld

CD----IDIQSIIHKLRGQRSGMIQTA
        |. |. .|| ||  |.|. 
vaaktrDlisiivnelrkqrismvqnl
0048179 (Phosphotyrosine protein) phosphatases II 385-493 8.4e-22 72.9 In-house 48-131 (144) alignment 
Range on Protein: 385-493
Range on HMM: 48-131/144.0
MsvavgegdpreIYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRDrlrksiPGlGPTLVHCSAGIGRTGTFLVIDIVLdlirhygiDCDIDIQSIIHKLR
.           ..||....|||||||.    .|...  |.....      .| ||.|||||||.|||||. ......         .......... .|
e...........giqylhlpwpDhgvpdllellleflefieeale......eg.gpvlVHCsaGvgRtgtlvaaylmk........klglsleealalvr

GQRSGMIQTA
 .|.|.... 
srrpgavpnp
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 385-465 1.3e-09 31.8 In-house 208-293 (349) alignment 
Range on Protein: 385-465
Range on HMM: 208-293/349.0
MSVAVGEGDPREIYQYHYTSWPDHGVPPE-REFLQLIM-K---IRQHRDRLRKSIPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIR
 .. . . .| |..|  .  |.| ..  .   .|| .  |   | .   ||      | . ||||||| ||||..  .|..|... 
daillavekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsile
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 394-494 2.3e-15 50.9 In-house 88-181 (440) alignment 
Range on Protein: 394-494
Range on HMM: 88-181/440.0
PREIYQYHYTSWPDHGVPperEFLQLIMKIRQHRDRLRKsIPGLGPTLVHCSAGIGRTGTFLVIDIVLdliRHYGIDCDIDIQSIIHKLRGQRSGMIQTA
 | . |||| .|||.|||   .|   ..|. |  .  ..   | || ||||||| ||||  ...| .|   |.     .||| |.|  .| .|  |.|| 
srtlkqyhyqgwpdkgvp...kfagpvlkmiqdvnesqe.kagngpllvhcsagagrtgviiavdsil...reakrsdqidifsfinsmrnnrpqmvqtp

V
 
e
subfamily_PTPDC1_pd Subfamily PTPDC1 395-493 2.7e-06 21.9 In-house 81-162 (182) alignment 
Range on Protein: 395-493
Range on HMM: 81-162/182.0
REIYQYHYtSWPDHGVPPEREFLQLImKIRQHRdrLRKsipglGPTLVHCSAGIGRTGTFLVIDivldLIRHYgidcDIDIQSIIHKLRGQRSGMIQTA
..|| | . .|.|.||.. .. |... |. .    |..     | . ||| || ||||  .       |. .     ... .  |...| .|.  ||| 
qgiyvynf.gwkDygvasleriLdiv.kvvafa..lqe.....gkvavhChaGlGrtGvliacy....lvyak....rltaekaiklvrskrpksiqtr
0038934 (Phosphotyrosine protein) phosphatases II 396-458 3.5e-09 32.1 In-house 74-136 (194) alignment 
Range on Protein: 396-458
Range on HMM: 74-136/194.0
EI----YQYHYTSWPDHGVPPEREFLQLIMKIRQHRDRLRKSipglGPTLVHCSAGIGRTGTFLVID
|.    ..|.   .||.|..|  | |. .... ..  .  ..    |  .||| ||.|||||...  
efekagieylklpfpddgtvPsleillrfldlvdeflnedpg....gvvaVHCkaGlgRtGtlvaaY
PTPc_DSPc_SM00012 397-493 3.1e-27 90.2 In-house 2-93 (105) alignment 
Range on Protein: 397-493
Range on HMM: 2-93/105.0
IYQYHYTSWPDHGVPPE-REFLQLIMKIRQHRDRLRKsipgLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGidCDIDIQSIIHKLRGQRSGMIQTA
...||||.||||||| |  ..|.|. ......    .     .|..||||||.|||||| ..||.|. ...      .||. |...|| ||.||.|| 
vkhyhytgwpdhgvPeesdsilellravkknknkses....skpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqte
PTEN_1 397-454 6.7e-08 27.6 In-house 94-147 (196) alignment 
Range on Protein: 397-454
Range on HMM: 94-147/196.0
IYQYHYTSWPDHGVPPEREFLQLIMKIRQHRDRLRKsipgLGPTLVHCSAGIGRTGTF
 ..|.  ...|||.|. .|..  . .. . . ....     .  |||| ||.||.|| 
gveylhfpieDhgapslselfdicksfiewllsdpn....gnvVlVHCkaGlgRsGtv
subfamily_CG42327_pd Subfamily CG42327 437-493 2.6e-07 24.6 In-house 247-301 (319) alignment 
Range on Protein: 437-493
Range on HMM: 247-301/319.0
LGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYgiDCDIDIQSIIHKLRGQRSGMIQTA
 ||  |||| |.||||. .  || .  . .      .||  ... .| .|.  ..| 
qGPlvvhcsdGvGrtGlviasdiairslees..krsvdiPqlvssvrrdrasavltk