Gene SAC1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Sac
Subfamily SAC1
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP071_AA protein Get Run
MbreP071_AA_193-515 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Sac_COG5329 26-522 1e-96 316.2 In-house 37-523 (1070) alignment 
Range on Protein: 26-522
Range on HMM: 37-523/1070.0
IDRHSFEIRSGAAAKLDSAVDAGEFYALYGLLRLLSGPYLVLVCGVEAA-ARINGHVIYSASDFELMPVASKTTGLVVE--------QQRAEERCLDLiR
... .. ...  . ...|   | | | ..||. |    .| .. |.. . ..|.|. ||   ... ...  .      .        ..|.|. |. | .
caaelvavselkkegfrslssaheiygvlGlielegslflivitgkskvaqvipgetiykilavdfislnnnkwddeeiesdeasteklrsehpcsel.k

TVLKQRGLYFSYTYDVTSPFSQQsKFTTNRDLYDIADRRFFCNRLLLEDLLDVpeaqRHRIGLTLCTRLQAHPLLVPFAHGFFRsQELTSLSGQAYTFAL
 .|.    |||...|.|. . ..  ..     .| ||..|. |. |||.|..     |...  .    |.   .|..  .||.  .  ...... .. .|
kLlsngsFYfStdfditntLqkr.lkeelelsvdtadeefmwnsflleeliny....rsklsslekqlldnagFlttvIrGFae.tvfikvkkktiaLtl

FSRRSLGRIGTRFHSRGVRISGHCANHVESEQVLVCGTAASCFVQVRGSIPLCWSQPPDLRYKPPFRMSEYDD-SNLACQRHLSDLCTRFGPCLCINLVN
 ||||  | |||| .|||  .|..|| || ||..        |.|||||||. |.|   . ..|. . .. .  .  | ..| . |  . |.   .||..
ISRrSskragtRflarGvDddGnvanFVETEqIvyssqycfsFtQvRGSiPiFWeqesnsligpkiqitrsseatqsafdkHFdklfekYGdvhivNLlk

KTGSEGILGSRFQDVLQsIERALPIKSEWFDFHHECRNMQWQHLAKLKASTSNWRQHQGISTMSLTSGRLAHRQKGVIRTNCIDVLDRTNVVQTMFAQDA
. .||  | .|.. .|.  .  ..|.   ||||.|....... . ||     .    .|  . .   |.|  .|.||.||||.| ||||||.|.. .. .
tKssEieLseryekhlk.lsekpkihlteFdfhketsqdgfddvkkLlplieqdllefgyfsydvkegkliseQdGVfRtNClDCLDRTNviQqliskrv

LLLQLQHLAEFLNLAPTtatesalatswpGLLTTFRGTWADHADEISIQYAGTPAQKSDFTRTGKRTLRGTLRDLYHSALRYFHNNFLDGGKQDALLLLT
|| |.. .    .                 .|. ..  |||..| || .| || | ||.|||.|||.. | |.|.  |. |.. ||| |..||||  ||.
lleqfrsikvisaidde............dflqklneLWadnGDaisqiYTGtgalkssftrkgkrsiagalsDatkSvsRmyinnfvDkekQdaidllL

GQVRVRT
|. . ..
gklpdqe
subfamily_SAC1_pd Subfamily SAC1 45-522 6.6e-186 609.4 In-house 2-457 (458) alignment 
Range on Protein: 45-522
Range on HMM: 2-457/458.0
VDAGEFYALYGLLRLLSGPYLVLVCGVEAAARINGHVIYSASDFELMPVASKTTGLVVEQQRAEERCLDLIRTVLKQRGLYFSYTYDVTSPFSQQSK---
... ......|...||||.||.... .|...||||.|||...|.|..||..... |. ||...|...|.|...|||....|||||||.|.......|   
aevvkiagilGiikLlsgkylivitkkeevgringkviyrvadveiipvkknslslteeqkkeekeylkllelvlksetfYfsytydltnslqrlekvts

-FTTNRDLYDIADRRFFCNRLLLEDLLDVPEAQRhrigltlctrlqahpLLVPFAHGFFRSQELtSLSGQAYTFALFSRRSLGRIGTRFHSRGVRISGHC
 ....|.|...||.|||.|. ||||| ..||...               ...|...||....|| ||......|.|.||||. |.|||...|||. .|..
aalkerslleradeRffwnkhlledlrkepeles...............filPvikGfikikel.slnakeikfilisRRsifRaGtRyfvRGvdkeGnv

ANHVESEQVLVCGTAASCFVQVRGSIPLCWSQPPDLRYKPPFRMSEYDDSNLACQRHLSDLCTRFGPCLCINLVNKTGSEGILGSRFQDvLQSIERALPI
||.||.||.... .|...||||||||||.||| |.|.||| ...||..||. |...||.......|.....|||...|||  ||..... .......  |
anfvEtEqiveaekaltsFvqvRGsiPllWsqkpnLkykPkvklsesedsldafkkhldeqielygenvlvnLvdqkGsEkklgeayes.vvralnkkki

KSEWFDFHHECRNMQWQHLAKLKASTSNWRQHQGISTMsLTSGRLAHRQKGVIRTNCIDVLDRTNVVQTMFAQDALLLQLQHLAeflnlapTTATESALA
|...||||.|||.|.|..|..|...........|....  ........||||.||||||.||||||||...|...|  ||..|.       ..||||.|.
kyvafDFHkeCrkmrwdrlklLidqlekelsqegyflk.seekkivkeqkgvvRtnCiDcLDRtnvvqsllarevLqkqleslg.......vlateskle

TSwPGLLTTFRGTWADHADEISIQYAGTPAQKSDFTRTGKRTLRGTLRDLYHSALRYFHNNFLDGGKQDALLLLTGQVRVRT
.| . |.|.|...|||.||..|.||||| |.|.||||||||||.|.|||...|. ||..|||||| .||.. |..|..||.|
ds.aeletsfknlwadnadavsvqYaGtgAlKtDftRtGkrtllGalrDgvnsvsryyknnfldgerqdsidLflgkyrvet
subfamily_FIG4_pd Subfamily FIG4 49-522 5.3e-70 227.3 In-house 69-545 (569) alignment 
Range on Protein: 49-522
Range on HMM: 69-545/569.0
EFYALYGLLRLLSGPYLVLVCGVEAAARINGHVIYSASDFELMPVASKTTGlvVEQQRAEERCLDLIRTVLKQRGLYFSYTYDVTSPFSQQSKFTTNRDL
  | . |..|.|.| ||.||   .. | | ||.||  .| .|........    |..  |.| | | . |  .. .||||.||.| .. . .  . ... 
sayGilGfvrflegyylilvtkrkkvaviGghaiykiedialikitedskk..sekssdearylklfkdvdltknfyfsysydltrtlqtnlllsdsnre

Y----DIADRRFFCNRLLLEDLLdvpeAQRHRIGLTLCTRLQAHPLLVPFAHGFFRsQELTSLSGQAYTFALFSRRSLGRIGTRFHSRGVRISGHCANHV
     | .|.   ...|  .. .    .  . .  .|   .. .  |.   |||.. |.  |. |.  . .| .|||    |.||  |||  .|..||.|
kekaedrvditieakkldanekf....vWnnflleplkdtvktfdWlleiihGfvs.qskisvlgksiyvtliarrsskfaGarflkrGvnnkGdvanev

ESEQVL-------VCGTAASCFVQVRGSIPLCWSQPP-DLRYKPPFRMSEYDDSNLACQRHLSDLCTRFG-PCLCINLVN---KTGSEGILGSRFQDVLQ
|.||..       .     | |||.|||.|| |||    |  ||| .. . |    |  .|..|| .|.| | . .|||    |.  | || . |.. ..
eteqivheasegsldsdryssfvqlrGsvPlyWsqdasklvtkPpikidvvdPfasaaalhfddlfqryGspiiilnlvkkkekrkresilleefeaaie

SIERALPIKS----EWFDFHHECRNMQWQHLAKLKASTSNWRQHQGISTMSLTSgRLAHRQKGVIRTNCIDVLDRTNVVQTMFAQDALLLQLQHLAEFLN
 . . || ..      .|...  .. . ..|..|.  ...  ...|| . . .. . ...|.|..||||.| |||||. | . .. ||  ||..|    .
ylneflPeekklkyiswdmaraskskeenvlevlekyaeksvkktGiflsapdl.estkiqeGivrtnCvdcldrtnaaqfvigkvalgyqlkslGiide

laPTTATESalatswpGLLTTFRGTWADHADEISIQYAGTPAQKSDFTRTGKRTLRGTLRDLYHSALRYFHNNFLDGGKQDALLLLTGQVRVRT
  ..   .|        . . .   . |. | ...||.|.   ..  | .  ...    ||. ..  ||. | | |  ||||. |. |. . |.
..sklefds.......dvvrlleelyedlGdtlalqygGsqlvntiktyrkiaqwssksrdiletlkryysnsfvdadkqdainlflGvyspre
Syja_N SacI homology domain 50-357 2.7e-73 237.9 Pfam-A 1-318 (319) alignment 
Range on Protein: 50-357
Range on HMM: 1-318/319.0
FYALYGLLRLLSGPYLVLVCGVEAAARIN-GHVIYSASDFELMPVASKTTGLV------VEQQRAEERCLDLIRTVLKQRGLYFSYTYDVTSPFSQQSKF
.|...||.||||. ||... . | .|.|. .| ||.  ..|..|. |...          |....||. | |....|.....||||.||.|. . ..|. 
aygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksek

TTN--------RDLYDIADRRFFCNRLLLEDLLDVPeaqrhrigltlctrLQAHPLLVPFAHGFFRSQELTSLSGQAYTFALFSRRSLGRIGTRFHSRGV
...          |.. .|.||. || ||..|...               |... .|.|. .||. .....  |.. ....| ||||  | |||. .||.
eeeekeeeskslpllkevderFvWNrnllkplielk..............ldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGi

RISGHCANHVESEQVLVCG----TAASCFVQVRGSIPLCWSQPPDLRYKPPFRMS-EYDDSNLACQRHLSDLCTRFGPCLCINLVNKTGSEGILGSRFQD
  .|..||.||.||....          |||.|||.||.|.|...| .||. ... . ..|  |...|...|. |.|.....||..|.|.|. |......
dddGnvANfvEtEqivsekkeeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayee

VLQSI----ERALPIKSEWFDFHHECRNMQWQ
 ....    ..   .| ..||||.||......
linklnkklkekkklkyiefDfhkeckgkkfe
Syja_N SacI homology domain 50-357 2.7e-73 237.9 In-house 1-318 (319) alignment 
Range on Protein: 50-357
Range on HMM: 1-318/319.0
FYALYGLLRLLSGPYLVLVCGVEAAARIN-GHVIYSASDFELMPVASKTTGLV------VEQQRAEERCLDLIRTVLKQRGLYFSYTYDVTSPFSQQSKF
.|...||.||||. ||... . | .|.|. .| ||.  ..|..|. |...          |....||. | |....|.....||||.||.|. . ..|. 
aygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksek

TTN--------RDLYDIADRRFFCNRLLLEDLLDVPeaqrhrigltlctrLQAHPLLVPFAHGFFRSQELTSLSGQAYTFALFSRRSLGRIGTRFHSRGV
...          |.. .|.||. || ||..|...               |... .|.|. .||. .....  |.. ....| ||||  | |||. .||.
eeeekeeeskslpllkevderFvWNrnllkplielk..............ldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGi

RISGHCANHVESEQVLVCG----TAASCFVQVRGSIPLCWSQPPDLRYKPPFRMS-EYDDSNLACQRHLSDLCTRFGPCLCINLVNKTGSEGILGSRFQD
  .|..||.||.||....          |||.|||.||.|.|...| .||. ... . ..|  |...|...|. |.|.....||..|.|.|. |......
dddGnvANfvEtEqivsekkeeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayee

VLQSI----ERALPIKSEWFDFHHECRNMQWQ
 ....    ..   .| ..||||.||......
linklnkklkekkklkyiefDfhkeckgkkfe
subfamily_Synaptojanin_pd Subfamily Synaptojanin 50-519 2.1e-68 222.5 In-house 6-437 (754) alignment 
Range on Protein: 50-519
Range on HMM: 6-437/754.0
FYALYGLLRLLS----GPYLVLVCGVEAAARINGHVIYSASDFELMPVASKTTGLvveqqraeERCLDlIRTVLKQRGLYFSYTYDVTSPFSQQSkFTTN
 |.| | ||| .      .|||| |..   .|..  |.  .. ||....|...          .|  . .. .|.   .||| . | .| .. ..  . .
aygllGvlrlnagdetlsflvlvtgcksvGkisdaeifkitstelvslrseasde........driie.lkkllasgtfyfsssadsasrldlsl.saqr

RDLYDIADRRFFCNRLLLEDLldvpeaQRHRIgltlctrlQAHPLLVPFAHGFFRSQELTSLSGQAyTFALFSRRSLGRIGTRFHSRGVRISGHCANHVE
|.  .  | ||| ||.|   |      ||. .        ...  |..   |  . . .   . ||   || || |  | ||||. |||   |. || ||
rkqeesednrffWnrslhlhl......qrfgv........ncddWllkvmcGsveirtvyagakqa.kaalisrlsceraGtrfnvrGvndeGnvanfve

SEQVLVCGTAASCFVQVRGSIPLCWSQPPDLRYKPPFRM-SEYDDSNLACQRHLSDLCTRFGPCLCINLVNKTGSEGILGSRFQDVLQSIERALPIKSEW
 |||.. . . . |||.|||.|| |.||     .   ..  ... |. | .|||. | .|.| ....||. . ..| .| . |.. |.. | |  ..   
teqvillddkvtsfvqirGsvPlfWeqPGlqvGshkvklsrgfeasaaafdrhleqlkeryGevvivnllGskegeevlskafkkhlkasehakdvpfvk

FDFHHECRNMQWQHLAKLKASTS-NWRQHqgISTMSLTSGRLAHRQKGVIRTNCIDVLDRTNVVQTMFAQDALLLQLQHLAeflnLAPTTATESAlatsw
||.|....  . ..|.||.  .  .. ..   |  . . ... ..|.||.|.||.| ||||| |||..... |  ||. |     |.  . . |      
fdyhqkvkggkkeklekllkkqlklfles..asfflskgkevekeqtGvlrvnClDCldrtnavqtvlglevlekqlealk....lsskesvvsr.....

pgLLTTFRGTWADHADEISIQYAGTPAQKSDfTRTGKrtlrgtLRDLYHSALRYFHNNFLDGGKQDAL-LLLTGQVR
  .  .|.  |    ||||  |||| | ... ....|      |.|   |  | ..|||||. ||.|. |||.|.. 
..feevfkslWsknGdeiskiyaGtgalegk.akvsk......lkdgarsvartiqnnfldsskqeaidllllgnty
subfamily_INPP5F_pd Subfamily INPP5F 101-522 2.4e-87 285.0 In-house 115-510 (951) alignment 
Range on Protein: 101-522
Range on HMM: 115-510/951.0
VVEQQRAEERCLDLIRTVLKQRGLYFSYTYDVTSPFsQQSKFTTNRDLYDIADRRFFCNRLLLEDLLDVPEAQRHRigltlctrlqahpLLVPFAHGFFR
. |....|.| |. ... |...  |.|...|.|. . |.  .. . .  |  |.||| |. ||.||... . . ..             .|.|   ||  
qneeeklekrlleelkkllsdgsFYysldfDltntl.qkrgleeksestddwderFfWNkfllkdlinyrdkldke.............fltpviqGfve

SQELTSLsGQAYTFALFSRRSLGRIGTRFHSRGVRISGHCANHVESEQVLVCGTAASCFVQVRGSIPLCWSQPpDLRYKPPFRMSE-YDDSNLACQRHLS
..|..    .  . .| ||||  | ||||..||.  .|..|| ||.|..|   .    |.|.|||.|. |.|. . .|||. ..    .... | ..|..
tkeisie.klkvsltlisrrSrkragtrfkrrGidddgnvAnfvEtElilsvekyvlsftqirGSvPvfweqs.gkkykpkikitrseeetqpaFdehfk

DLCTRFGPCLCINLVNKTGSEGILGSRFQDVLQSIErALPIKSEWFDFHHECRNMQWQHLAKLKASTSNWRQHQGISTMSLTSgRLAHRQKGVIRTNCID
 .  ..|.   .||.....|| .|...... |. .|    ..   ||||.|......... ||  .  |  .. |   .  .  ..  .||||.||||.|
eqlkkygkvvivnllsqkssekklskaykeqllkle.skdvflikfdfheetsgekfenvsklielikneikevgyfsydvke.kviseqkgvfRtnclD

VLDRTNVVQTMFAQDALLLQLQHLAEFlnlAPTTATESalatswPGLLTTFRGTWADHADEISIQYAGTPAQKSDFTRTGKRTLRGTLRDLYHSALRYFH
 ||||||||.. .. .| |||. |  |    |..  ..      . ||...  .|||. | ||.|||||.| |.|.||.|.| | | | |.| |. ||. 
cldrtNvvqqaiskavlelqleklglf...epessidd......eellqklkklWadngdaisrqYagtnalkgdltrkgerklaGvlkdgyksvsryyl

NNFLDGGKQDALLLLTGQVRVRT
||| | ..|... ||.|...   
nnfkdkyrqkvidlllGklpkqe