Gene SYNJ in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Sac
Subfamily Synaptojanin
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP072_AA protein Get Run
MbreP072_AA_200-503 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Synaptojanin_pd Subfamily Synaptojanin 54-791 0.0 1051.6 In-house 2-748 (754) alignment 
Range on Protein: 54-791
Range on HMM: 2-748/754.0
KRYDVYGAIGVLELPTekGsDVTAPVLLVVMDCKSNGRLPGCQVYHISRIDLVYLASAAHDErphDYYCTyLKQLFATGSFYFSAREESLApganftasa
|  |.||..|||.| .  | | |. .|..|..|||.|.........|....||.|.|.|.||   |.... ||.|.|.|.||||  ..|           
kivdaygllGvlrlna..g.detlsflvlvtgcksvGkisdaeifkitstelvslrseasde...driie.lkkllasgtfyfsssadsas.........

rlTVHLPSACQRASRSPGErDSSYFWTRVPWTWVSRHGIASQDWLLPVIRGSVQIRTVYAGSEQICCLLVSRLSNARSGMRFNTRGVDDEGNAANFVETE
  ...|....||....  | |...||.|. .....|.|....||||.|..|||.|||||||..|....|.||||..|.|.|||.|||.||||.|||||||
..rldlslsaqrrkqeese.dnrffWnrslhlhlqrfgvncddWllkvmcGsveirtvyagakqakaalisrlsceraGtrfnvrGvndeGnvanfvete

QVIFAGKHILSFVIARGSVPIFWSQPGLNVGQHKVQLTREFAATQPAFQRHFDQLAAAYGHTVIVSLLGLKGGEYTLESQFEKH--ASTYDPDMPFVHFD
|||.......|||..|||||.||.||||.||.|||.|.|.|.|...||.||..||...||..|||.||| |.||..|...|.||  ||....|.|||.||
qvillddkvtsfvqirGsvPlfWeqPGlqvGshkvklsrgfeasaaafdrhleqlkeryGevvivnllGskegeevlskafkkhlkasehakdvpfvkfd

VHAKCRGNKKAVKMLPLVKQLRTWLTSDSFFSLTGKRVNHEQLGIIRVNCLDCLDRTNLCQSVVGLAVLEDMLGTLKseLDLRESKLLEFRRVFALMWSV
.|.|..|.||....  | |||...|.|.|||. .||.|..|| |..|||||||||||| .|.|.||.|||..| .||  |. .||.. .|..||. .||.
yhqkvkggkkeklekllkkqlklflesasfflskgkevekeqtGvlrvnClDCldrtnavqtvlglevlekqlealk..lsskesvvsrfeevfkslWsk

NGDNVSRCVTGTGAISGGVKTSKLKDMQRSVVRTFKNNFMDSRRQAAIDLLL--GTYRDGQADE--LVIPNVLMR-------------QRLDEAMRLRI-
|||..|....||||..|..|.|||||..|||.||..|||.||..|.||||||   ||.. .||.   .....|.|             |.|.||..||| 
nGdeiskiyaGtgalegkakvsklkdgarsvartiqnnfldsskqeaidllllgntyveeladkarallkssllrasakilkelvereqelteakklric

---------NDYSDVMPINGlCIDEWLIRPRSRLSEDQGNELGIYAIGFQEMVDLNASNMIKTAQTNRLEWANEICTILGDD--YALLTSVQLVGICLFV
         .....|.  |  ....||..  .  .... .  .||||||.|.|||||||......||| |||.|....|..|  |.||||.||||.||||
vgtwnvnggkqlrsvalkne.sltdwlldlpelsgaedskpadiyaiGfeelvdlnasnlvsasttnrkewaeelqkvlsrdakyvlltseqlvGvclfv

LVRTDLVDVVRDVCTCTVKTGAGGKVGNKGAVAVRLRLYNTPICFICSHLTAGKSHVAERNQDYHDIYRRIDFGKGRVLDSHSAVFWFGDFNYRIDLENL
.||..||...|||...|||||.||..|||||||.||.|..|..|||||||.||.|.|.|||.||..|.|.|.|..||.|.||..|||.||||||||||. 
fvrpklvpfirdvavstvktGlgGaaGnkGavairlllhstslCfiCshlaagqskvkernedyaeiarkiafpmgrtleshdyvfWlGdfnyridlekd

ECRQACADKDLATLKEHDQLTRERARLAVFDSFNEPPIHFLPTYKYDFDSDVYDTSEKQRVPSWTDRAQ
|.......||...|.|.||||..... .||..|.|. ..| ||||||..||.||||||.|||.||||..
evkelvkkkdydklvendqltkqkkkgkvfkgfaegeltfaPtykydlfsddydtseklrvPaWtdrvl
Sac_COG5329 56-790 4.9e-120 393.4 In-house 59-813 (1070) alignment 
Range on Protein: 56-790
Range on HMM: 59-813/1070.0
YDVYGAIGVLelptekgsDVTAPVL-LVVMDCKSN-GRLPGCQVYHISRIDLVYLASAAHDERPHD------YY------CTYLKQLFATGSFYFSAree
. .|| .|..        ...  .   |. . ..  .. || ..|.|  .| . |     |.   .      ..      |  ||.|. .||||||    
heiygvlGli........elegslflivitgkskvaqvipgetiykilavdfislnnnkwddeeiesdeasteklrsehpcselkkLlsngsFYfSt...

slapgaNFTASARLTVHlpSAcQRASRSPGERDSSYFWTRVPWTWVS----RHG-IAS-----QDWLLPVIRGSVQIRTVYAGSEQICCLLVSRLSNARS
      .|  . .|  .  .  .  . |  . | ...| .   ...     ..  ...     ...| .|||| ..   .. . ..|.  |.||.|  |.
......dfditntLqkr..lk.eelelsvdtadeefmwnsflleelinyrsklsslekqlldnagFlttvIrGFaetvfikvkkktiaLtlISRrSskra

GMRFNTRGVDDEGNAANFVETEQVIFAGKHILSFVIARGSVPIFWSQPGLNVGQHKVQLTREFAATQPAFQRHFDQLAAAYGHTVIVSLLGLKGGEYTLE
| ||..|||||.||.||||||||.. . ... ||.. |||.||||.| . .  . |.| ||.. |||.||..|||.|  .||  .|| ||. |. |  | 
gtRflarGvDddGnvanFVETEqIvyssqycfsFtQvRGSiPiFWeqesnsligpkiqitrsseatqsafdkHFdklfekYGdvhivNLlktKssEieLs

SQFEKHAStYDPDMPF--VHFDVHAKCR--GNKKAVKMLPLVKQLrtwLTSDSFFS--LTGKRVNHEQLGIIRVNCLDCLDRTNLCQSVVGLavlEDMLG
...|||     .....  ..|| |....  | ... |.|||..|    |..  .||     ...  || |..|.||||||||||. |.....   . .| 
eryekhlk.lsekpkihlteFdfhketsqdgfddvkkLlplieqd...llefgyfsydvkegkliseQdGVfRtNClDCLDRTNviQqlisk...rvlle

TLKSELDLRESKLLEFRRVFALMWSVNGDNVSRCVTGTGAISGGVK-------TSKLKDMQRSVVRTFKNNFMDSRRQAAIDLLLGTYRDGQADELVIP-
 ..|. .  ...  .|   .  .|. ||| .|.  |||||... .         ..|.|.  || | . |||.|  .| ||||||| ..| .| ||  | 
qfrsikvisaiddedflqklneLWadnGDaisqiYTGtgalkssftrkgkrsiagalsDatkSvsRmyinnfvDkekQdaidllLgklpdqeavelydpi

----NVLMRQRLDEAMRLRI-NDYSDVMPINGLCIDEWLIRprsRLSEDQGNELGIYAIGFQEMVDLNASNMIKTAQTNRLEWANEICTILG--------
    |.  |... |  . .. .  .  . .||... . |.    .| .  .  .  .  |... .. .  ..|. .. .. |. .|  ..|         
neyvnlrlrkseseftaaknvsiftltfnsngessstkllk...lllkvlekkisklvvgvvglqkqiwlelillssltksefkeeeeenlvrkyenklk

DDYALLTSVQLVGICLFVLVRTDLVDVVRDVCTCTVKTGAGGKVGNKGAVAVRLRLYNTPICFICSHLTAGKSHVAERNQDYHDIYRRIDFGKGRVLDSH
. . .  |.|| .. ... .. |   ||  .   . ||| ||. .|||||...     . ..|  ... ...  . |||..|  | .|. .. . .   |
kkkleqsssqltalfilfkksadikevvssekaagrktgtgglnankgavkieaeseglvfifvdasaaledenesernskyesitkrvskeipkmikdh

SAVFWFGDFNYRIDLENLECRQACADKDLATLKEHDQLTRERARLaVFDSFNEPpIHFLPTYKYDFDSDVYDTSEKQRVPSWTDR-A
   .. ...|..||... | |..  ...   ||. |.   ..    ..... || ............ | .||....... ...|  
qlilldiainltidydeeevraekekeidrelkkydtkqeltekv.fvekvlep.tevpellekksyeddndtdtedayrklrtrkl
subfamily_SAC1_pd Subfamily SAC1 58-507 1.5e-87 285.1 In-house 7-454 (458) alignment 
Range on Protein: 58-507
Range on HMM: 7-454/458.0
VYGAIGVLELptekgsdVTAPVLLVVMDCKSNGRLPGCQVYHISRIDLVYLASAAH-----DERPHDYYCTYLKQLFATGSFYFSAReeslapgANFTAS
..| .|...|       .... |.|. . .. ||. | ..|... .... ....       ...  . | . |.... . .|||| .        ..| |
iagilGiikL.......lsgkylivitkkeevgringkviyrvadveiipvkknslslteeqkkeekeylkllelvlksetfYfsyt.......ydltns

ARLTVHLPSACQRASRSPGERDSSYFWTRVPWTWVSRHGiASQDWLLPVIRGSVQIRTVYAGSEQICCLLVSRLSNARSGMRFNTRGVDDEGNAANFVET
 . . .  ||  . . .    |. .|| .   . ....    ....||||.| ..|...   ...|   |.|| |  |.| |...|||| |||.||||||
lqrlekvtsaalkerslleradeRffwnkhlledlrkep.elesfilPvikGfikikelslnakeikfilisRRsifRaGtRyfvRGvdkeGnvanfvEt

EQVIFAGKHILSFVIARGSVPIFWSQPGLNVGQHKVQLTrEFAATQPAFQRHFDQLAAAYGHTVIVSLLGLKGGEYTLESQFEKH-ASTYDPDMPFVHFD
||.. | |.. |||  |||.|..||| .    . ||.|. | . .. ||..|.|.. . ||..|.|.|.  || | .|....|.   .. .... .| ||
EqiveaekaltsFvqvRGsiPllWsqkpnLkykPkvkls.esedsldafkkhldeqielygenvlvnLvdqkGsEkklgeayesvvralnkkkikyvafD

VHAKCRGNKkAVKMLPLVKQLRTWLTSDSFFSL-TGKRVNHEQLGIIRVNCLDCLDRTNLCQSVVGLAVLEDML---GTLKSELDLRESklLEFRRVFAL
 | .|| ..   ..  |..||...| . ..|.  . |.. .|| |..| ||.|||||||. ||...  ||.. |   |.|..|  |..|   |. ..|  
FHkeCrkmr.wdrlklLidqlekelsqegyflkseekkivkeqkgvvRtnCiDcLDRtnvvqsllarevLqkqleslgvlateskleds..aeletsfkn

MWSVNGDNVSRCVTGTGAISG-----GVKT--SKLKDMQRSVVRTFKNNFMDSRRQAAIDLLLGTYR
.|. |.|.||   .||||.       | .|    |.|.  ||.| .||||.|  || .|||.||.||
lwadnadavsvqYaGtgAlKtDftRtGkrtllGalrDgvnsvsryyknnfldgerqdsidLflgkyr
Syja_N SacI homology domain 59-361 3.1e-68 221.3 Pfam-A 2-317 (319) alignment 
Range on Protein: 59-361
Range on HMM: 2-317/319.0
YGAIGVLELPTekgsdvtAPVLLVVMDCKSNGRLPG-CQVYHISRIDLVYLASAAHDER-----------PHDYYCTYLKQLFATGSFYFSAReeslapg
|| .|...|           .|||. .... ... |  ..|.| ..... | |......            ...... ||.|. .||||||         
ygilGlirlls.......esyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSyd.......

anftasARLTVHLPSACQRAS----------RSPGERDSSYFWTRVPWTWVSRHGIASQDWLLPVIRGSVQIRTVYAG-SEQICCLLVSRLSNARSGMRF
        || .| . .....              | |. ..| |   . . . ... ..||||.|.| |..|...   .... ..|.|| |  |.|.|.
......yDltrslqrksekeeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRy

NTRGVDDEGNAANFVETEQVIF-A-G--KHILSFVIARGSVPIFWSQ-PGLNvGQHKVQLTREFAATQPAFQRHFDQLAAAYGHTVIVSLLGLKGGEYTL
..||.||.||.||||||||...      |...|||. |||||.||.| ..|.  ..|...||.  |.|.||..||..|   ||. |.|.||. ||.|  |
lrRGidddGnvANfvEtEqivsekkeeskrvfSfvqiRGSvPlfWeqasnls.lkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkL

ESQFEKHASTY------DPDMPFVHFDVHAKCRGNKK
....|......      . .. ...||.|..|.|.| 
seayeelinklnkklkekkklkyiefDfhkeckgkkf
Syja_N SacI homology domain 59-361 3.1e-68 221.3 In-house 2-317 (319) alignment 
Range on Protein: 59-361
Range on HMM: 2-317/319.0
YGAIGVLELPTekgsdvtAPVLLVVMDCKSNGRLPG-CQVYHISRIDLVYLASAAHDER-----------PHDYYCTYLKQLFATGSFYFSAReeslapg
|| .|...|           .|||. .... ... |  ..|.| ..... | |......            ...... ||.|. .||||||         
ygilGlirlls.......esyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSyd.......

anftasARLTVHLPSACQRAS----------RSPGERDSSYFWTRVPWTWVSRHGIASQDWLLPVIRGSVQIRTVYAG-SEQICCLLVSRLSNARSGMRF
        || .| . .....              | |. ..| |   . . . ... ..||||.|.| |..|...   .... ..|.|| |  |.|.|.
......yDltrslqrksekeeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRy

NTRGVDDEGNAANFVETEQVIF-A-G--KHILSFVIARGSVPIFWSQ-PGLNvGQHKVQLTREFAATQPAFQRHFDQLAAAYGHTVIVSLLGLKGGEYTL
..||.||.||.||||||||...      |...|||. |||||.||.| ..|.  ..|...||.  |.|.||..||..|   ||. |.|.||. ||.|  |
lrRGidddGnvANfvEtEqivsekkeeskrvfSfvqiRGSvPlfWeqasnls.lkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkL

ESQFEKHASTY------DPDMPFVHFDVHAKCRGNKK
....|......      . .. ...||.|..|.|.| 
seayeelinklnkklkekkklkyiefDfhkeckgkkf
subfamily_FIG4_pd Subfamily FIG4 80-508 5.3e-48 154.7 In-house 85-543 (569) alignment 
Range on Protein: 80-508
Range on HMM: 85-543/569.0
LLVVMDCKSNGRLPGCQVYHISRIDLVYLASAAHD--ERPH-DYYCTYLKQLFATGSFYFSAREE-SLAPGANFT--ASARLTVHLPSACQ-RASRSPGE
|..|   |. . . | ..|.|. |.|.....  .   . .. . |   .|..  |  ||||   . . .   | .  .| | . .  ....   . .  .
lilvtkrkkvaviGghaiykiedialikitedskksekssdearylklfkdvdltknfyfsysydltrtlqtnlllsdsnrekekaedrvditieakkld

RDSSYFWTRVPWTWVSRhGIASQDWLLPVIRGSVQIRTVYAGSEQICCLLVSRLSNARSGMRFNTRGVDDEGNAANFVETEQVI-------FAGKHILSF
 .  . |    .  ..   . . |||| .| | |.  ..    ..|   |..| |.  .| ||  |||. .|. || |||||..       .. ... ||
anekfvWnnflleplkd.tvktfdWlleiihGfvsqskisvlgksiyvtliarrsskfaGarflkrGvnnkGdvaneveteqivheasegsldsdryssf

VIARGSVPIFWSQPGLNV-GQHKVQLTREFAATQPAfQRHFDQLAAAYGHTVIV-SLLGL---KGGEYTLESQFEKHASTYDP------DMPFVHFDVHA
|  |||||..|||   .. .. .... .     ..|  .|||.|   ||  .|.  |.     .  | .|...||.  .  .        . ....|.. 
vqlrGsvPlyWsqdasklvtkPpikidvvdPfasaa.alhfddlfqryGspiiilnlvkkkekrkresilleefeaaieylneflPeekklkyiswdmar

KCRGNKKaVKMLPLVKQLRTWLTSD-SFFSLTGKRVNHEQLGIIRVNCLDCLDRTNLCQSVVGLAVLEDMLGTL---K-SELDLrESkllEFRRVFALMW
. . ...   .  | |  .. .. .  |.| .  .  . | ||.|.||.|||||||  | |.|   |   | .|   . |.|.. .|   .  |..  ..
askskee.nvlevlekyaeksvkktGiflsapdlestkiqeGivrtnCvdcldrtnaaqfvigkvalgyqlkslGiidesklef.ds...dvvrlleely

SVNGDNVSRCVTGTG---AISGGVK----TSKLKDMQRSVVRTFKNNFMDSRRQAAIDLLLGTYRD
   ||...   .|.     |.   |    .|| .|. ... | . | |.|  .| ||.|.||.|. 
edlGdtlalqygGsqlvntiktyrkiaqwssksrdiletlkryysnsfvdadkqdainlflGvysp
subfamily_INPP5F_pd Subfamily INPP5F 110-790 3e-164 539.5 In-house 114-799 (951) alignment 
Range on Protein: 110-790
Range on HMM: 114-799/951.0
SAAHDERPHDYYCTYLKQLFATGSFYFSAreeslapganftaSARLTVHLPSACQRASRSP-GERDSSYFWTRVPWTWVSRHGIAS-QDWLLPVIRGSVQ
.  ..|. ..  .  ||.|.  ||||.|              .  ||  |.. ..    .   . |...|| .     .        . .|.|||.| |.
eqneeeklekrlleelkkllsdgsFYysl.............dfDltntlqkrgleeksestddwderFfWNkfllkdlinyrdkldkefltpviqGfve

IRTVYAGSEQICCLLVSRLSNARSGMRFNTRGVDDEGNAANFVETEQVIFAGKHILSFVIARGSVPIFWSQPGLNVgQHKVQLTREFAATQPAFQRHFDQ
.....   ...   |.|| |  | |.||..||.||.|| |||||||... . |..|||.  |||||.||.|.|  . . |...||....|||||..||..
tkeisieklkvsltlisrrSrkragtrfkrrGidddgnvAnfvEtElilsvekyvlsftqirGSvPvfweqsgkky.kpkikitrseeetqpaFdehfke

LAAAYGHTVIVSLLGLKGGEYTLESQFEKHASTYD-PDMPFVHFDVHAKCRGNKKAvKMLPLVKQLRTWLTSDSFFSLTGKR-VNHEQLGIIRVNCLDCL
..  ||..|||.||  |. | .| ......  ... .|. ...|| | ...|.| . ..  |.....  ...  .||   |. |  || |..|.||||||
qlkkygkvvivnllsqkssekklskaykeqllkleskdvflikfdfheetsgekfe.nvsklielikneikevgyfsydvkekviseqkgvfRtnclDcl

DRTNLCQSVVGLAVLEDMLGTLKSELDLRESKLLEFRRVFALMWSVNGDNVSRCVTGTGAISGGVKTS-------KLKDMQRSVVRTFKNNFMDSRRQAA
||||. |. ...|||| .|  |.      . .  |... .  .|. ||| .||  .|| |..| .           |||   || | . |||.|. ||..
drtNvvqqaiskavlelqleklglfepessiddeellqklkklWadngdaisrqYagtnalkgdltrkgerklaGvlkdgyksvsryylnnfkdkyrqkv

IDLLLGTYRDGQADELVIPNVLMRQRLDEAMRLRINDYSDVMPINGL-C-IDEWLIRPRSRLSEDQGNE--LGIYAIGFQEMVDLNASNMIKTAQTNRLE
||||||  .  .. ||  |.    .   . .  . ...|..  . |     ..      |.|  . |.     .. .| ||.|.| | ... . .. .  
idlllGklpkqevvelidpkkeekeeelrekeekftetsninllvgsvnvngsskkadlskllfpigekfkpDlvvlGLqEvvELtaGsiLaaDyskskf

WANEICTILGDD-----YALLTSVQLVGICLFVLVRTDLVDVVRDVCTCTVKTGAGGKVGNKGAVAVRLRLYNTPICFICSHLTAGKSHVAERNQDYHDI
| . . ..| .      | .| | ||... | . || | .  |..|   |.||| ||  |||||||||..  .|  ||. |||.||.| | || .||..|
WEklvedlLnkvsreekYlkLrseqlsslLlllfvredkakkvkevegdtkktGfgGlagnkGavavrfeysatsFcfvnsHlaAGasnveeRrsDykei

YRRIDFGKGRVLDSHSAVFWFGDFNYRIDLENLECRQACADKDLATLKEHDQLTRERARLAVFDSFNEPPIHFLPTYKYDFDSDVYDTSEKQRVPSWTDR
.| | |.... .  | ..||.||.|||||| | | |    |.... | |.||||.|     ||. |.|. ..| ||||||.... ||||||.|.|.||||
arsitFsrskrikdhDsifWlGDlnyRidlpneevRRelldqeidkLleyDqLtkeieaGevFegfkEetlkFrPtYkyDlgtknYDtsekeRtPaWtDR

A
 
i
Exo_endo_phos Endonuclease/Exonuclease/phosphatase family 572-790 2e-25 80.0 Pfam-A 34-224 (249) alignment 
Range on Protein: 572-790
Range on HMM: 34-224/249.0
GFQEMVDLNASNMIKTAQTNRLEWANEICTIL--GDDYalltsvqlVGICLFVLVRTDLVDVVRDVC---TCTVKTGAGGKVGNKGAVAVRLRlyNTPIC
 .||... . |.. .|     |  .. . .    |.|.        .|..| .|.. .|. ..|...   ....    ..  ||||.|.||.|  .....
lLQEvdedplsellatglaselgldgdgksggggggda........gggglallskypldkkirrtfqldgkagiavprlssgnkgdvpvrfr..gktla

FICSHLTAGKSHVA--ERnQDYHDIYRRIDFGKGRvldshsAVFWFGDFNYRIDLENlecrqacadkdlatlkehdqltrerarlavfDSFNEPPIHFLP
....|||.| .  .  || .....| .. |...|.       |...||||.|.|. .                               . |.|. . |||
lvntHltpgnrlrqrder.allaeidkladdsrgs......pvilaGDfNsrpdspd...............................kgfresaadflp

TYKYDFDSDVY-------------DTSEKQRVPSWTDRA
....|  .. .             ||.||.| |...|..
gdgfddglrallphlllptspgttdtyekareparlDyi