Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
CECR5_TIGR01456 | 2-78 | 2.2e-07 | 20.6 | In-house | 37-119 (370) | alignment | |||
Range on Protein: 2-78
Range on HMM: 37-119/370.0
KTKAVFVDISGTLLVGNAALPGAIDALARLKQN-----YTVRLVTNTSKESQRAIYERLT-TLGFAVEPSEVFTSLAATRALL
|. .. .|| | || |. ..|| .|| || .. | |.||. |.|| | | || |.| | | . . |
kkfgfaldiDGvllrGkkpiagaskalrrLvddqGalkiPvllltngGglseraraeelsalLgvevsplqviqshsPykklv
|
|||||||||
Hydrolase | haloacid dehalogenase-like hydrolase | 4-213 | 1.1e-07 | 23.8 | Pfam-A | 2-215 (215) | alignment | ||
Range on Protein: 4-213
Range on HMM: 2-215/215.0
KAVFVDISGTLLVGNAAL--PGAIDALARLKQN----------YTVRLVTNTSKE-----------------------SQRAIYERLTTLGFAVEPSEVF
|.|. |. |||. |. .. .|. ||| ... |. .. | . ... . ..|. ..|.. ..
ktvvfDktGTLtegepsvallgnkaalalaaaletgsehpigkavvaaakanstrggltgfatfigrgvsgkvdgivlgnpewmtalglrviapdlvaae
TslaatralllR----------DqrrcffiippateedfadvprdspDTVVLGLAPDS-FDYATLDTGFQILRQPDARLIAINtSRFYATPSGVHIAAGA
. . ..||. .. . . .. |.. .. . . | . .. ||
g..........qskgrtvvvvav........................qaralgviafadpvkpeaaeavasLkeaGievvllt.gdnpetaeaiakqagi
fvraleYAANVSAHVVGKPSAEFFRAAAASCHLDVESCVMIGDDTgDDFEGAMRAG
..| |.|||||. . |.||. .| . ..|.||. | ... .||
......edslvfaevvgkPepklfvaaieeLqidpgevamvGDgv.nDapalaaAg
|
|||||||||
subfamily_CUT_pd | Subfamily CUT | 4-77 | 7.1e-07 | 19.0 | In-house | 19-98 (391) | alignment | ||
Range on Protein: 4-77
Range on HMM: 19-98/391.0
KAVFVDISGTLLVGNAALPGAIDALARLKQN-----YTVRLVTNTSKESQRAIYERLT-TLGFAVEPSEVFTSLAATRAL
.. .|| | || |. .|.| .|| .|... | ..||.. .... |.| .|.. |.. .|. | . . |
fgivlDiDGvLlRgkkvipaakealklledkkgelkvPvvfltnggnftekekaeklsekLdvevdadqvllshsPlkll
|
|||||||||
Subfamily.CECR5.protein | 4-77 | 7.2e-07 | 19.0 | In-house | 21-100 (393) | alignment | |||
Range on Protein: 4-77
Range on HMM: 21-100/393.0
KAVFVDISGTLLVGNAALPGAIDALARLKQN-----YTVRLVTNTSKESQRAIYERLT-TLGFAVEPSEVFTSLAATRAL
.. .|| | || |. .|.| .|| .|... | ..||.. .... |.| .|.. |.. .|. | . . |
fgivlDiDGvLlRgkkvipaakealklledkkgelkvPvvfltnggnftekekaeklsekLdvevdadqvllshsPlkll
|
|||||||||
Chronophin_1 | 5-223 | 1.1e-36 | 117.7 | In-house | 3-230 (261) | alignment | |||
Range on Protein: 5-223
Range on HMM: 3-230/261.0
AVFVDISGTLLVGNAALPGAIDALARLKQN-YTVRLVTNTSKESQRAIYERLTTLGFA-VEPSEVFTSLAATRALLLR--DQRRCFFIIPP-----ATEE
| .|. | | |..|.||| .....|||. .| ||| |.. .. . .||. ||.. |. |.|.| .|..||| . . . . . .|.
lvLlDldGVlikgeeavpgAaeliealkqagkevlfvtNnsrrtreelaarlkrlGldavaaeeifssalaaaallrqqaakakvyvlGeeglrkelrea
D--FADVPRDSPDTVVLGLAPdSFDYATLDTGFQILRQPdARLIAINTSRFYATPSGVHIAAGAFVRALEYAANVSAHVVGKPSAEFFRAAAASCHLDVE
.| | |... ||.| . ..... | . . .|.. |...| | . ...|. ..|. ..|.| |.. ..|||||.. |..|. . .| |
GlrlvdepedrveaVvvGyde.elsfeklaeaialirdg.alfvatnrDptvPleeGiaPgtGslaaaveaAsgreplvvGKPepvmfeealekigadpe
SCVMIGDDTGDDFEGAMRAGLRAMLVATGR
. ||.|| | . . ||||...|| ||
etvmvGDRldTDilagaraglstllvltGv
|
|||||||||
Chronophin_2 | 5-83 | 2.8e-08 | 24.4 | In-house | 2-81 (282) | alignment | |||
Range on Protein: 5-83
Range on HMM: 2-81/282.0
AVFVDISGTLLVGNAALPGAIDALARLKQN-YTVRLVTNTSKESQRAIYERLTTLGFAVEPSEVFTSLAATRALLLRDQR
.|. | | . |. |..|| . . ||.. | .||| |. .. . .... |||| | . | | |..|||
nvlfdcdgviwngekavagapevvsrlaragknvlfvtnnstrarenyvlkfarlgfadvaaeqifssaycsaaylrdva
|
|||||||||
subfamily_LHPP_pd | Subfamily LHPP | 6-225 | 4.9e-89 | 289.1 | In-house | 1-222 (227) | alignment | ||
Range on Protein: 6-225
Range on HMM: 1-222/227.0
VFVDISGTLLVGNAALPGAIDALARLKQNY-TVRLVTNTSKESQRAIYERLTTLGFAVEPSEVFTSLAATRALLLRDQRRCFFIIPPATEEDFADVPRDS
|..|.||.| ...||.|||..||.||.|.. .||.||||.|||.||..|||..|||.|| .|.||||.|.|.|| ... |..... ...||||.|. .|.
vllDlsGvlhnedaaipgavealkrLrqagvkvrfvtNttkeskralverLirlgfdveeeeiftsleaarqllrerklrpyllveddveedfedidtdk
PDTVVLGLAPDSFDYATLDTGFQILRQ-PDARLIAINTSRFYATPSGVHIAAGAFVRALEYAANVSAHVVGKPSAEFFRAAAASCHLDVESCVMIGDDTG
|..||.||||.||.|.||...|..| . ..|.|||||....|....|.....||||.|||||..|.|.|||||||.||..| .....|.|..||||||.
pnavviglapesfeyetlnqafrllleakkakliainkgkyykrkdGlalgpGafvkaleyatgvkaevvGKPsalffekaleelgvdpeeavmiGDdve
DDFEGAMRAGLRAMLVATGRFD
||.|||..||||..|| ||.|
dDveGAlkaGlrgvlVktGkfr
|
|||||||||
Hydrolase_6 | Haloacid dehalogenase-like hydrolase | 6-97 | 5.3e-18 | 56.3 | Pfam-A | 1-95 (101) | alignment | ||
Range on Protein: 6-97
Range on HMM: 1-95/101.0
VFVDISGTLLVGNAALPGAIDALARLKQN-YTVRLVTNTSKESQRAIYERLTTLGFAVEPSEVFTSLAATRALLLR--DQRRCFFIIPPATEEDF
...|. |.|. |. |.||| .|| .|... ..| |.|| |..|.... ..|. ||..|....|.|| |....| . ......| . .| .
flfDvdGvLwrgdkaipgaaealkalraagkpvvllTNnsskseeeyakkleklgvdvteeqvvtsataaaeylkkrkadkkvlvigeeglreel
|
|||||||||
subfamily_PGP_pd | Subfamily PGP | 6-81 | 2.7e-11 | 34.3 | In-house | 2-79 (279) | alignment | ||
Range on Protein: 6-81
Range on HMM: 2-79/279.0
VFVDISGTLLVGNAALPGAIDALARLKQ-NYTVRLVTNTSKESQRAIYERLTTLGFA-VEPSEVFTSLAATRALLLRD
|..|. |.| |. |.|||..||..||. . | .||| | .|.. . .... ||| |. .|...| ||. . | ..
vlfDcDGVlWlgetaipgaaealnaLkklgKkvlfvtNnstksreellkkfkklgfekvkeeeilssaaaiadyLkqk
|
|||||||||
subfamily_PGP_pd | Subfamily PGP | 105-223 | 1.5e-18 | 58.1 | In-house | 130-248 (279) | alignment | ||
Range on Protein: 105-223
Range on HMM: 130-248/279.0
PDTVVLGLApDSFDYATLDTGFQILRQPDARLIAINTSRFYATPSGVHI-AAGAFVRALEYAANVSAHVVGKPSAEFFRAAAASCHLDVESCVMIGDDTG
. || |. . ..|| | ..||.|.. ..| |. ... ...| | ||..|.|.| |.. .. |.|||. . . . . ..| | ..|||| .
vgAVvvgvd.eklsyakllkAanyLrepevlflatneDallplkkevvipgaGslvaaieaasgrkplvlGKPnelllelllekeeidpertlmiGDrlk
DDFEGAMRAGLRAMLVATGR
| . . ||...|| .|
tDilfgkncGlqtLlvlsGv
|
|||||||||
Chronophin_2 | 107-222 | 4.2e-13 | 40.2 | In-house | 127-243 (282) | alignment | |||
Range on Protein: 107-222
Range on HMM: 127-243/282.0
TVVLGLAPDSFDYATLDTGFQILRQPDARLIAINTSRFYATPSGVHI-AAGAFVRALEYAANVSAHVVGKPSAEFFRAAAASCHLDVESCVMIGDDTGDD
|| ... . | ||..| |.| .. .. .| . .|.. ||| |.. | |.|||| .| . .| ..|||| |
ravlvgydekltflklakacaylrdadclllatdrdpwhplsdgritpgsgsltaaletasgrkatvigkpsrfmfecissqfsvdparslmigdrletd
FEGAMRAGLRAMLVATG
. . || ..| ||
ilfgsncglstvltltg
|
|||||||||
HAD_2 | Haloacid dehalogenase-like hydrolase | 171-218 | 1.1e-07 | 23.6 | Pfam-A | 129-175 (176) | alignment | ||
Range on Protein: 171-218
Range on HMM: 129-175/176.0
HVVGKPSAEFFRAAAASCHLDVESCVMIGDDTgDDFEGAMRAGLRAML
. . ||. |... ... .... | ...|.| .|.|.| ||.|. .
vgapKpdpeayekvlerlgvkpeeilfidDsl.edveaAraaGirtvh
|
|||||||||
Hydrolase_like | HAD-hyrolase-like | 173-226 | 1.6e-15 | 48.1 | Pfam-A | 2-55 (75) | alignment | ||
Range on Protein: 173-226
Range on HMM: 2-55/75.0
VGKPSAEFFRAAAASCHLDVESCVMIGDDTGDDFEGAMRAGLRAMLVATGRFDA
|||.......|.. .... ...|||||. .| |.| .||.|. ||.|| ...
lgKPnpgmydkalevlgappsevvmiGDslatDieaAnnaGirsilVltGvsre
|