Gene LHPP-2 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family NagD
Subfamily LHPP
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP080_AA protein Get Run
MbreP080_AA_22-266 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Chronophin_1 23-266 3.4e-23 73.4 In-house 3-233 (261) alignment 
Range on Protein: 23-266
Range on HMM: 3-233/261.0
VFVLDQYGVIHNGSAPYPHAVEVVQRLRQAGKTVTILSNSSK-PAHFAHARLIEWGFG--EVATIVTGGEMVRQGMRNrwsdfAAYGSKYTLMGwdvETD
.. ||  ||. .| .  |.| |....|.||||.|....| |. . .   ||| . |.   ..  |..     .. .|.     .| ..|  ..|   |  
lvLlDldGVlikgeeavpgAaeliealkqagkevlfvtNnsrrtreelaarlkrlGldavaaeeifssalaaaallrq.....qaakakvyvlG...eeg

VLADLDQYDQAPIDEADFillQGINVLSTGSEPAPIEEVAHWQPHLKAArARnlpIVCANPDKVVVRPDGsQGLCPGTVAAMYE-ALGGQVHYVGKPHAL
. ..|..     .||..    .   |.    |    |..|.   ..... |.    | .|.|. | ...|      |..||. | | | . ..||||...
lrkelreaGlrlvdeped...rveaVvvGydeelsfeklaeaialirdg.al...fvatnrDptvPleeG.iaPgtGslaaaveaAsgreplvvGKPepv

VYDKTLEQLAgVPKSRIVAVGDSLHHDIEGALKAGLDCVFVTGGVHAP
 ....||. . .  .. |.||| |  ||. . .|||. . |  ||  .
mfeealekig.adpeetvmvGDRldTDilagaraglstllvltGvsel
subfamily_LHPP_pd Subfamily LHPP 24-267 1e-78 255.4 In-house 1-224 (227) alignment 
Range on Protein: 24-267
Range on HMM: 1-224/227.0
FVLDQYGVIHNGSAPYPHAVEVVQRLRQAGKTVTILSNSSKPAHFA-HARLIEWGFG-EVATIVTGGEMVRQGMRNRWSdfaaygSKYTLMGWDVETDvL
..||..||.||..|..|.|||...||||||..|....|..|....| ..|||..||. |...|.|..|..|| .|.|..      ..|.|. .|||.| .
vllDlsGvlhnedaaipgavealkrLrqagvkvrfvtNttkeskralverLirlgfdveeeeiftsleaarqllrerkl......rpyllveddveed.f

ADLDqYDQaPideadfillqgiNVLSTGSEPAPIEEVAHWQPHLKAARARNLPIVCANPDKVVVRPDGsQGLCPGT-VAAMYEALGGQVHYVGKPHALVY
.|.| .|. |            |....|..|...|. ...|.. ....|.. .....|..|...|.|| . |.||. |.|...|.| ....||||.||..
edid.tdk.p............navviglapesfeyetlnqafrllleakkakliainkgkyykrkdG.lalgpGafvkaleyatgvkaevvGKPsalff

DKTLEQLaGVPKSRIVAVGDSLHHDIEGALKAGLDCVFVTGGVHAPE
.|.||.| ||.....|..||....|.||||||||..|.|..|...||
ekaleel.gvdpeeavmiGDdvedDveGAlkaGlrgvlVktGkfrpe
Hydrolase_6 Haloacid dehalogenase-like hydrolase 24-91 1.9e-12 38.5 Pfam-A 1-70 (101) alignment 
Range on Protein: 24-91
Range on HMM: 1-70/101.0
FVLDQYGVIHNGSAPYPHAVEVVQRLRQAGKTVTILSNSSKPA-HFAHARLIEWGFGEV-ATIVTGGEMV
|..|  ||...|. ..|.|.|....||.|||.| .|.|.|.   .  ...| . |.      .|| ....
flfDvdGvLwrgdkaipgaaealkalraagkpvvllTNnsskseeeyakkleklgvdvteeqvvtsataa
subfamily_PGP_pd Subfamily PGP 24-67 2e-07 21.6 In-house 2-45 (279) alignment 
Range on Protein: 24-67
Range on HMM: 2-45/279.0
FVLDQYGVIHNGSAPYPHAVEVVQRLRQAGKTVTILSNSSKPAH
...|  ||. .|. . | |.|....|...|| |....| |  ..
vlfDcDGVlWlgetaipgaaealnaLkklgKkvlfvtNnstksr
Chronophin_2 25-82 1.8e-07 21.7 In-house 4-62 (282) alignment 
Range on Protein: 25-82
Range on HMM: 4-62/282.0
VLDQYGVIHNGSAPYPHAVEVVQRLRQAGKTVTILSNSSKPAH-FAHARLIEWGFGEVA
..|  ||| ||    . |.|||.|| .||| | ...| |. |      ..   || .||
lfdcdgviwngekavagapevvsrlaragknvlfvtnnstrarenyvlkfarlgfadva
Hydrolase haloacid dehalogenase-like hydrolase 26-253 6.4e-10 31.1 Pfam-A 116-215 (215) alignment 
Range on Protein: 26-253
Range on HMM: 116-215/215.0
LDQYGVIHNGSAPYPHAVEVVQRLRQAGKTVTILS-NSSKPAHFAHARL-Iewgfgevativtggemvrqgmrnrwsdfaaygskytlmgwdvetdvlad
.  .|||.    ..|.| |.|..|..||  | .|. . ...|. ..... |                                                 
aralgviafadpvkpeaaeavasLkeaGievvlltgdnpetaeaiakqagi.................................................

ldqydqapideadfillqginvlstgsepapieevahwQ--------PhlkaararnlpivcanpdkvvvrpdgsqglcpgtvaamyealggqvhyvGKP
                                                                                                 |||
......................................edslvfaevv.................................................gkP

HALVYDKTLEQLAGVPKsRIVAVGDSLhHDIEGALKAG
.  .. ...|.|   |. ....|||..  |.... .||
epklfvaaieeLqidpg.evamvGDgv.nDapalaaAg
HAD_2 Haloacid dehalogenase-like hydrolase 33-66 3.5e-06 18.7 Pfam-A 73-106 (176) alignment 
Range on Protein: 33-66
Range on HMM: 73-106/176.0
HNGSAPYPHAVEVVQRLRQAGKTVTILSNSSKPA
.  . ..|..||...||...|. . ||||.|..|
esrlelfpdvvellrrlkakgvklvilSngsaea
Chronophin_2 188-264 6.6e-07 19.9 In-house 169-245 (282) alignment 
Range on Protein: 188-264
Range on HMM: 169-245/282.0
DGSQGLCPGTV-AAMYEALGGQVHYVGKPHALVYDKTLEQLAgVPKSRIVAVGDSLHHDIEGALKAGLDCVFVTGGVH
||..    |.. ||.  | | .   .|||   ...   .|.  |  .| . .|| |. ||    . ||. |.   || 
dgritpgsgsltaaletasgrkatvigkpsrfmfecissqfs.vdparslmigdrletdilfgsncglstvltltgvs
subfamily_PGP_pd Subfamily PGP 196-267 9.1e-10 29.3 In-house 181-252 (279) alignment 
Range on Protein: 196-267
Range on HMM: 181-252/279.0
G-TVAAMYEALGGQVHYVGKPHALVYDKTLEQlAGVPKSRIVAVGDSLHHDIEGALKAGLDCVFVTGGVHAPE
| .|||. .| | .  ..|||. |. .  ||.   .  .| . .||.|. ||  . . ||  ..|  ||.. |
GslvaaieaasgrkplvlGKPnelllelllek.eeidpertlmiGDrlktDilfgkncGlqtLlvlsGvtkle
HAD_2 Haloacid dehalogenase-like hydrolase 208-259 2.6e-10 32.1 Pfam-A 128-176 (176) alignment 
Range on Protein: 208-259
Range on HMM: 128-176/176.0
QVHYvGKPHALVYDKTLEQLaGVPKSRIVAVGDSLhHDIEGALKAGLDCVFV
.|..  ||.  .|.| ||.| ||.. .|. ..||| .|.|.| .||...|.|
dvga.pKpdpeayekvlerl.gvkpeeilfidDsl.edveaAraaGirtvhv
Hydrolase_like HAD-hyrolase-like 212-268 2.5e-18 57.1 Pfam-A 2-57 (75) alignment 
Range on Protein: 212-268
Range on HMM: 2-57/75.0
VGKPHALVYDKTLEQLaGVPKSRIVAVGDSLHHDIEGALKAGLDCVFVTGGVHAPEL
 |||.. .||| ||.| |.|.|..| .||||..|||.| .||.....|..||...| 
lgKPnpgmydkalevl.gappsevvmiGDslatDieaAnnaGirsilVltGvsreed