Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| subfamily_CUT_pd | Subfamily CUT | 11-83 | 5.3e-07 | 19.4 | In-house | 15-91 (391) | alignment | ||
Range on Protein: 11-83
Range on HMM: 15-91/391.0
IESTKLFVFDCDGVIWRGATLIDGVADALDGLRRH-GK---RVAFITNNSTKTRANFVKKFHGLGLTWVERDDVWSS
.|. .|.| |||. || .| .. .|| | .. |. | |.||.. | . .| . . |. |.| |
sassfgivlDiDGvLlRgkkvipaakealklledkkgelkvPvvfltnggnftekekaeklsekLdvevdadqvlls
|
|||||||||
| Subfamily.CECR5.protein | 11-83 | 6.3e-07 | 19.2 | In-house | 17-93 (393) | alignment | |||
Range on Protein: 11-83
Range on HMM: 17-93/393.0
IESTKLFVFDCDGVIWRGATLIDGVADALDGLRRH-GK-R--VAFITNNSTKTRANFVKKFHGLGLTWVERDDVWSS
... .|.| |||. || .| .. .|| | .. |. . | |.||.. | . .| . . |. |.| |
sakkfgivlDiDGvLlRgkkvipaakealklledkkgelkvPvvfltnggnftekekaeklsekLdvevdadqvlls
|
|||||||||
| Chronophin_1 | 16-298 | 1.4e-74 | 241.8 | In-house | 3-259 (261) | alignment | |||
Range on Protein: 16-298
Range on HMM: 3-259/261.0
LFVFDCDGVIWRGATLIDGVADALDGLRRHGKRVAFITNNSTKTRANFVKKFHGLGLTWVERDDVWSSASAAAAYLTQrakLDKSRKVYVVGQSGLCEEL
|. .|.|||...|.....| |... |...||.| |.||||..||.........|||. |. . ..||| ||||.|.| . . ||||.|..|| .||
lvLlDldGVlikgeeavpgAaeliealkqagkevlfvtNnsrrtreelaarlkrlGldavaaeeifssalaaaallrq...qaakakvyvlGeeglrkel
CEAGYTVLGGPDDegssvfpvperfevdpAVGAVVVGFDRAINYYKLAYATMCARENkdCLFLATNRDAITHLNDEqEFPGGGTMVAALETAIGRAPEVA
|||... ..|.| .| |||||.|. ... ||| |.. |. .||.||||| . |.. || |...||.|.| ||.| |
reaGlrlvdeped................rveaVvvGydeelsfeklaeaialirdg..alfvatnrDptvPleeG.iaPgtGslaaaveaAsgreplvv
GKPSPFLVDALYAFHGLdrDSAHAVMVGDRLDTDIIFGNTNNMATLLVMSGVTRQSHVDATQpgEDDYPTYIAPSLKLLADTL
|||.|.. .. |. |....||||||||||| .|. . ||||..||.... . |.. .| |.... |.. |...|
GKPepvmfeealekiga..dpeetvmvGDRldTDilagaraglstllvltGvseleeaqayk..kdlrPdavvesiadlleel
|
|||||||||
| subfamily_PGP_pd | Subfamily PGP | 17-297 | 5.3e-101 | 328.6 | In-house | 2-278 (279) | alignment | ||
Range on Protein: 17-297
Range on HMM: 2-278/279.0
FVFDCDGVIWRGATLIDGVADALDGLRRHGKRVAFITNNSTKTRANFVKKFHGLGLTWVERDDVWSSASAAAAYLTQrakLDKSRKVYVVGQSGLCEELC
..||||||.|.| |.|.| |.||. |...||.|.|.||||||.|....|||. ||...|......|||.|.|.||.| .. ||||.|..||.|||.
vlfDcDGVlWlgetaipgaaealnaLkklgKkvlfvtNnstksreellkkfkklgfekvkeeeilssaaaiadyLkq...kkfekkvyvlgeeglkeeLk
EAGYTVLGGPDDEGSSVFP--VPERFEVDPAVGAVVVGFDRAINYYKLAYATMCARENKdCLFLATNRDAITHLNDEQEFPGGGTMVAALETAIGRAPEV
|||...||..... .. . . |....|..|||||||.|....|.||..|... ||.. .||||||.||...|..|. .|| |..|||.|.|.||.| |
eagiellgtgpeklkdeldedfveelkldkdvgAVvvgvdeklsyakllkAanyLrepe.vlflatneDallplkkevvipgaGslvaaieaasgrkplv
AGKPSPFLVDALYAFHGLDRDsaHAVMVGDRLDTDIIFGNTNNMATLLVMSGVTRQSHVDATQPGEDDYPTYIAPSLKLLADT
|||...|...|. . .|.. ...|.||||.||| ||..... ||||.||||....|.... |...|.|...||. |...
lGKPnelllelllekeeidpe..rtlmiGDrlktDilfgkncGlqtLlvlsGvtkledveeikkeeklvPdyyldsladllel
|
|||||||||
| Chronophin_2 | 17-272 | 2.2e-70 | 228.1 | In-house | 3-249 (282) | alignment | |||
Range on Protein: 17-272
Range on HMM: 3-249/282.0
FVFDCDGVIWRGATLIDGVADALDGLRRHGKRVAFITNNSTKTRANFVKKFHGLGLTWVERDDVWSSASAAAAYLTQRAKLdkSRKVYVVGQSGLCEELC
.|||||||| | . . | .. .. | |.||.| |.|||||..| |.|.|| ||.. | ....||| .|||| . |.. . ||.|.| || .||
vlfdcdgviwngekavagapevvsrlaragknvlfvtnnstrarenyvlkfarlgfadvaaeqifssaycsaaylrdvadv..rgkvfviggeglrkelr
EAGYTVLGGPDDEGSSVFPVPErfevDPAVGAVVVGFDRAINYYKLAYATMCAReNKDCLFLATNRDAITHLNDEQEFPGGGTMVAALETAIGRAPEVAG
||| |.. .|.. .|.. ... || | ||.||.| . . ||| |. | . |||.|||.|| |.| . || |.. |||||| || | |
eagvpvvedadeqeasiydcal....dpdvravlvgydekltflklakacaylr.dadclllatdrdpwhplsdgritpgsgsltaaletasgrkatvig
KPSPFLVDALYAfhGLDRDSAHAVMVGDRLDTDIIFGNTNNMATLLVMSGVTRQSH
|||.|. . . .. | |...|.||||.|||.||. ..|.| ..||..
kpsrfmfeciss..qfsvdparslmigdrletdilfgsncglstvltltgvsslee
|
|||||||||
| Hydrolase_6 | Haloacid dehalogenase-like hydrolase | 17-120 | 4.1e-33 | 104.8 | Pfam-A | 1-100 (101) | alignment | ||
Range on Protein: 17-120
Range on HMM: 1-100/101.0
FVFDCDGVIWRGATLIDGVADALDGLRRHGKRVAFITNNSTKTRANFVKKFHGLGLTwVERDDVWSSASAAAAYLTQRaklDKSRKVYVVGQSGLCEELC
|.||.|||.||| ..|.|.|.||. ||..||.|...||||.|......||.. ||. |. ..|..||.|||.|| .| .. .||.|.|. ||.|||
flfDvdGvLwrgdkaipgaaealkalraagkpvvllTNnsskseeeyakkleklgvd.vteeqvvtsataaaeylkkr...kadkkvlvigeeglreelk
EAGY
|||.
eaGf
|
|||||||||
| subfamily_LHPP_pd | Subfamily LHPP | 17-271 | 3.5e-26 | 83.5 | In-house | 1-224 (227) | alignment | ||
Range on Protein: 17-271
Range on HMM: 1-224/227.0
FVFDCDGVIWRGATLIDGVADALDGLRRHGKRVAFITNNSTKTRANFVKKFHGLGLTwVERDDVWSSASAAAAYLTQRAKldksRKVYVVGQSGLcEELC
.. | ||.. . . | | ..||. ||..|..| |.||.. ..... |.. ||. || ... .|..||...| .| |....| .. |..
vllDlsGvlhnedaaipgavealkrLrqagvkvrfvtNttkeskralverLirlgfd.veeeeiftsleaarqllrerkl....rpyllveddve.edfe
EAGYTVLggpddegssvfpvperfevdpavGAVVVGFD-RAINYYKLAYATMCARENKDCLFLATNRDAITHLNDEqEFPGGGTMVAALETAIGRAPEVA
. . |||.| ...| .| | . |.|. .| |.. . .| | |. |.||| |.| ||
didtdkp.......................navviglapesfeyetlnqafrllleakkakliainkgkyykrkdG.lalgpGafvkaleyatgvkaevv
GKPSPFLVDAlyAFHGLDRDSAHAVMVGDRLDTDIIFGNTNNMATLLVMSGVTRQS
||||... .. | . |. | ..|||.|| . |. . . ..|| .|. |..
GKPsalffek..aleelgvdpeeavmiGDdvedDveGAlkaGlrgvlVktGkfrpe
|
|||||||||
| Hydrolase_like | HAD-hyrolase-like | 215-291 | 9.7e-17 | 52.0 | Pfam-A | 2-72 (75) | alignment | ||
Range on Protein: 215-291
Range on HMM: 2-72/75.0
AGKPSPFLVDAlyAFHGLDRDSAHAVMVGDRLDTDIIFGNTNNMATLLVMSGVTRQSHVDAtqpgEDDYPTYIAPSL
|||.|...|. | . |. .....||.||.|.|||...| .. ..|| .||.|. .. . |.|....|
lgKPnpgmydk..alevlgappsevvmiGDslatDieaAnnaGirsilVltGvsreedlkl....akakpdyvvddl
|
|||||||||