Gene DSP10 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP10
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP005_AA protein Get Run
NvecP005_AA_268-409 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 120-230 4.2e-15 48.3 Pfam-A 10-111 (113) alignment 
Range on Protein: 120-230
Range on HMM: 10-111/113.0
DEESIVLIDCRPLLAYNYCHIKGAIHVNCSSIgrkrlqQGKTKLKDLITSKEGKEKYVSGCKSRTSFIVYDdvtRGEEFSPCRAAVLLVMqaLFKE-GK-
..|..||.|.|.  .|.  ||.||..|. .|.      .....|..    .|  |..  .... .  .||.   |. . |   ||.|| .  ..|| |  
ekekvvllDvRspeeyakghIpgAvnvpldsl......yprrdlffkdklaeeleesgkkldkdktvvvyc...rsgnrsggaaalllal..ilkelgyk

DVFFLKGGLREFC
.|..|.||. .. 
nvyvLdGGfeawk
PTEN_1 259-408 4.5e-30 99.9 In-house 32-188 (196) alignment 
Range on Protein: 259-408
Range on HMM: 32-188/196.0
PDLCPTRP--RgppasSILPFLFLGSEEGA-ADEDLIDRLAIKFILNLTPVCPN-------FFSEREDIIYKRIQINDSYQEDIGQHFDEAIAFIDEARS
 . .|.||  .      | ..|..||.. . || |  .   | ...||.. ...        . ......|... |.|    .. ..||..  ||. ..|
mgkapsrpllq.....eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewlls

--RGSSVLVHCHAGVSRSATVTVAYVMQHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKYE
  .|  |||||.||..||.||  || |.. .|. .|| ..|.|||| ..||  ..  ||.|.
dpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyf
subfamily_DSP10_pd Subfamily DSP10 261-409 5.8e-72 234.8 In-house 2-151 (159) alignment 
Range on Protein: 261-409
Range on HMM: 2-151/159.0
LCPTRP--RGPPASSILPFLFLGSEEGAADEDLIDRLAIKFILNLTPVCPNFFSErEDIIYKRIQINDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCH
|.||..  .. |||..|||||||||..|||.|..|||.|...||.|. .||.|.| |.. ||||...|...... |.|.||..||.|||..||.|||||.
lspteadietapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCq

AGVSRSATVTVAYVMQHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKYEK
||.||||||..||.|.||.||||.||.|||||||.|||||||||.||..||
aGisrsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefek
0044763 (Phosphotyrosine protein) phosphatases II 265-409 1.4e-40 134.2 In-house 17-168 (178) alignment 
Range on Protein: 265-409
Range on HMM: 17-168/178.0
RPRGPPASSILPFLFLGSEEGAADEDLIDRLAIKFILNLTPVC-------PNFFSEREDIIYKRIQINDSYQEDIGQHFDEAIAFIDEAR-SRGSSVLVH
| ....|| |||.|.|||   |.| .|. .| |. |.|||. .       .  . |...| |..| | |.   |. .||.|...||.||. ..|. ||||
rsdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVH

CHAGVSRSATVTVAYVMQHLGLSLNEAYQFVKEKRPtISPNLNFMGHLLKYEK
|.|||.||.|. .|| | .|||||.||...|.|.|| |.|| ...  |...|.
CsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefel
0041856 (Phosphotyrosine protein) phosphatases II 267-408 1.6e-32 108.0 In-house 15-169 (182) alignment 
Range on Protein: 267-408
Range on HMM: 15-169/182.0
RGPPASSILPFLFLGSEEG--------------AADEDLIDRLAIKFILNLTpvCPNFFSERE---DIIYKRIQINDSYQEDigqhFDEAIAFIDEARSR
.... . |.. |.|||  .              |.. ... .| |. |.|||  ... . |..    | |..... |    |    .||...||.|....
hsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevlee

GSSVLVHCHAGVSRSATVTVAYVMQHLGLSLNEAYQFVKEKRP--TISPNLNFMGHLLKYE
|  |||||.|||.|..|. .||.| .||.|| ||...|...||   |.|| .|. .|. .|
ggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlalle
0045098 (Phosphotyrosine protein) phosphatases II 267-408 1.5e-26 88.8 In-house 18-268 (278) alignment 
Range on Protein: 267-408
Range on HMM: 18-268/278.0
RGPPASSILPFLFLGSEE-----------------------------------------GAADEDLIDRLAIKFILNLTPVCP-----------------
. .. |.|.|.|.||. .                                          |.. ...  | |. |..||.. .                 
llgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslt

-------------------------------NFFSEREDIIY--KRIQINDSYQEDIGQHFDEAIAFIDEARS--------------RGSSVLVHCHAGV
                               . . .|.  ..  . .  ...  ..| ..|.|.. ||.||..              .|  |||||.|||
ygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGv

SRSATVTVAYVMQHL---GLSLNEAYQFVKEKRPT-ISPNLNFMGHLLKYE
.|..|. .|| | .|   |..| ||.......||  . .||...  | ...
gRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefl
0049772 (Phosphotyrosine protein) phosphatases II 268-408 4.3e-33 110.8 In-house 155-270 (314) alignment 
Range on Protein: 268-408
Range on HMM: 155-270/314.0
GppassilpflflgSEEGAADEDLIDrlaikfilnltPVC--PNFFsEREDIIYKRIQINDsYQEDIGQHFDEAIAFIDEArSRGSSVLVHCHAGVSRSA
|             .|  ||| .|.            ...  |..| ||. | |.|| . | ..... ..|||...||.|| ..|. |||||.||..|..
g.............neptaadlellk...........eelydpelf.erlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtg

T-VTVAYVMQHLGLSLNEAYQFVKEKRPtISPNLNFMGHLLKYE
| |..||.| .||.||.||...|..||| |.|| .|.  |. ||
tfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqye
0046846 (Phosphotyrosine protein) phosphatases II 268-408 9.4e-29 95.8 In-house 9-169 (176) alignment 
Range on Protein: 268-408
Range on HMM: 9-169/176.0
GPPASSILPFLFLGSEE----------GAADEDLIDRLAIKFILNLTPV-------CPNFFSE--REDIIYKRIQINDSYQEDIgQHFDEAIAFIDEARS
... . |.. |.|||             |.. ... .| |. ..|||         |||...|  ...| |... . |    |. ....|...||.||..
dldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealk

RGSSVLVHCHAGVSRSATVTVAYVMQH-LGLSLNEAYQFVKEKRP-TISPNLNFMGHLLKYE
.|  |||||.||..|..|. .|| ...  |||..||...|.|.||  . .. ...  | ..|
eggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefe
subfamily_DSP1_pd Subfamily DSP1 270-409 7.6e-47 153.4 In-house 17-154 (163) alignment 
Range on Protein: 270-409
Range on HMM: 17-154/163.0
PASSILPFLFLGSEEGAADEDLIDRLAIKFILNLTPVCPNFFSEreDIIYKRIQINDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTV
|   ||.||.||||. |.. .....| |  |||..  ..|.| .     ||.....|| ..|| ..|.|.| ||||... .  ||.||.||.|||.|. .
PvekildfLylGsetvasnleiLkslgitailnvskeldnvfed..lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlcl

AYVMQHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKYEK
||.|..  .||.||..|||..|. ||||..|.. ||.|||
aylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyek
subfamily_DSP8_pd Subfamily DSP8 271-409 5e-47 153.4 In-house 15-152 (159) alignment 
Range on Protein: 271-409
Range on HMM: 15-152/159.0
ASSILPFLFLGSEEGAADEDLIDRLAIKFILNLTPVCPNFFSEREDIiYKRIQINDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVA
   ||..|.|||.. . .|.|...| | ..||.   ||.    .|.  . |. ..|.|.|.. . ||... ||| |.|  ..||||..|| |||||| .|
ptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkesk.flrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaia

YVMQHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKYEK
|.|..| .||.|||.|||||||||||||||.| ||.|||
yimktlemsldeayrfvkekrptispnlnflgqLleyek
subfamily_DSP19_pd Subfamily DSP19 271-408 3.4e-39 128.6 In-house 12-147 (152) alignment 
Range on Protein: 271-408
Range on HMM: 12-147/152.0
ASSILPFLFLGSEEGAADEDLIDRLAIKFILNLTPVCPNFFSerEDIIYKRIQINDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVA
.. . | |.||| ..|||.. ...  |  |||..   ||.|.  .|. |. |.| |  ..|. ....||. ||.||||    |||||.|||||||.| .|
vgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfp..kdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvvia

YVMQHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKYE
|.|..  |||.||.. |.|.||.|.||  |.  | .||
ylmkkeelsleealelvrearpcikPneGFikqLkeye
subfamily_DSP14_pd Subfamily DSP14 271-409 5.3e-39 127.7 In-house 7-142 (157) alignment 
Range on Protein: 271-409
Range on HMM: 7-142/157.0
ASSILPFLFLGsEEGAADEDLIDRLAIKFILNLTPVCPNffSEREDIIYKRIQINDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVA
 | | | |||.   .| ...|...  |  |.|.|.  ||   . .|| . .....|. .... .||||... |.|.. .|  .|||| |||||||....|
lsqitpsLfls.gvaalskellkkkkitliinvtvelpn..tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslcla

YVMQHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKYEK
|.|..  |||.|||. ||..|| |.||. |   | .|||
ylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEk
subfamily_Slingshot_pd Subfamily Slingshot 271-408 5.7e-39 127.2 In-house 19-154 (169) alignment 
Range on Protein: 271-408
Range on HMM: 19-154/169.0
ASSILPFLFLGSEEGAADEDLIDRLAIKFILNLTPVCPNFFSEreDIIYKRIQINDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVA
|| |  ...||||  |.. . ...  ...|||.|  . |||.|  .. |..|.. |. ..|. ....|.  ||..|...||.|||||  ||||||.. .|
askifdhvylGsewnasnleelkengveyilnvtkeidnffpe..kfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastvia

YVMQHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKYE
| |.. ||||.||...|||.|  | || .|.  | .||
yamkeyglsleealeyvkerrsvikPnkgflkqleeye
0048076 (Phosphotyrosine protein) phosphatases II 271-408 3.8e-35 116.0 In-house 4-139 (145) alignment 
Range on Protein: 271-408
Range on HMM: 4-139/145.0
ASSILPFLFLGSEEGAADEDLIDRLAIKFILNLTPVCPNFFseREDIIYKRIQINDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVA
.| ||| |.|||   | | .|. .| |. .||||. .....  |..| | .. . |    |. ....|...||.||...|  |||||.|||.|..|. .|
pseilpglylgslptaldlellkdlgittvlnltselelle..rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

YVMQHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKYE
|.| .||.|| ||...|...|| . || ...  |...|
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefe
0051082 (Phosphotyrosine protein) phosphatases II 271-404 6e-24 79.8 In-house 8-146 (151) alignment 
Range on Protein: 271-404
Range on HMM: 8-146/151.0
ASSILPFLFLGSEEGAADEDLIDRLAIKFILNLTP-----VCPNFFSEREdIIYKRIQINDSYQEDIGQHFDEAIAFIDEARSR-GSSVLVHCHAGVSRS
.| . ..|....   |.. .|. .| || |.||..      ||... | . | ...|.| |    .. ..||....|......  .  |||||.||..|.
fsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelg.ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRT

ATVTVAYVMQhLGLSLNEAYQFVKEKRP-TISPNLNFMGHL
.|. ..| |  ||.||.||......|||  . ||  |. .|
Gtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfql
PTPc_motif_SM00404 272-409 5.4e-44 144.5 In-house 3-139 (140) alignment 
Range on Protein: 272-409
Range on HMM: 3-139/140.0
SSILPFLFLGSEEGAADEDLIDRLAIKFILNLTPVCPNFfSEREDIIYKRIQINDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVAY
| ||| |.|||.. | ...|.. | |....|.| ....  .| ... ...|...|. .... ...|....||..|...| .||||| ||||||||...||
srilphlylgskskaqnpallkklgithvinvteevslt.kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

VMQHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKYEK
.|.  .|||.|||.||||.||.|||||||.  |..|||
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek
0048179 (Phosphotyrosine protein) phosphatases II 272-409 7.6e-36 118.3 In-house 5-142 (144) alignment 
Range on Protein: 272-409
Range on HMM: 5-142/144.0
SSILPFLFLGSEEGAADEDLIDRLAIKFILNLTPVCPNFFSEREDIIYKRIQINDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVAY
| ||| |.|||   | | .|. .| |. ..|||. ... | ||| | | .. . |    |. ....|...||.||...|  |||||.|||.|..|. .||
seilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay

VMQHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKYEK
.| .|||||.||...|...|| . || ...  ||.|||
lmkklglsleealalvrsrrpgavpnpgqlrfLleyek
subfamily_LRR-DSP_pd Subfamily LRR-DSP 272-409 7.4e-33 107.7 In-house 121-256 (263) alignment 
Range on Protein: 272-409
Range on HMM: 121-256/263.0
SSILPFLFLGSEEGAADEDLIDRLAIKFILNLTPVCPNFFSERedIIYKRI-QINDSYQEDIGQHFDEAIAFIDEARSRGsSVLVHCHAGVSRSATVTVA
. |.. ||||. . | .. ..  | .  ||     .  .| .     |  | .|.|  . || |||.|  |||.| | .|  ||||| ||||||.|....
deiidklflGgldsannksilkdlgvthillavadfePlfPkl..fkylsiddiedvdeadisqhfeetnafieeGrkkG.GvlvhcraGvsrsstlvis

YVMQHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKYEK
|.|..  | ..||. .|..||| | ||  |.  |.||||
ylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyek
subfamily_DSP15_pd Subfamily DSP15 272-409 1e-32 107.4 In-house 3-137 (151) alignment 
Range on Protein: 272-409
Range on HMM: 3-137/151.0
SSILPFLFLGSEEGAADEDLIDRLAIKFILNLTPvcpNFFSEREDIIYKRIQINDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVAY
| .|| |.||  . . ||.|...  |  ||..     |    ..|| || |...|. . .. ..|.|.. || ..|... .||||| ||||||.|..|||
skvlpglylgnfrdskdeelLkeknithilsvhd...nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaY

VMQHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKYEK
.|  . |. ..| ...|..| .  ||. |   | .|||
lmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyek
subfamily_DSP6_pd Subfamily DSP6 273-409 3.8e-57 186.2 In-house 16-152 (158) alignment 
Range on Protein: 273-409
Range on HMM: 16-152/158.0
SILPFLFLGSEEGAADEDLIDRLAIKFILNLTPVCPNFFSEREDIIYKRIQINDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVAYV
.|||.|.|||.. |.. .....| ||..||.|.  ||.| | ... |..| |.| ..... ..| |||.|||||||. |.|||||.||.||| |||.||.
eilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlayl

MQHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKYEK
|..| ||||.||..||.... ||||.|||| ||..|.
mkklalslndaydlvkkrksnisPnfnfmgqlldfer
subfamily_DSP12_pd Subfamily DSP12 273-409 1.2e-38 127.0 In-house 4-141 (155) alignment 
Range on Protein: 273-409
Range on HMM: 4-141/155.0
SILPFLFLGSEEGAADEDLIDRLAIKFILNLTPV-CPNFFSEREDIIYKRIQINDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVAY
 ||| |.||. | ...|.| . |.|. .| ..    |..  ..  . .| ||| |. .||| .|.|||..||.||.... .|||||.||||||.|. .||
rilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

VMQHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKYEK
.|.. .|||..|...||||.|.|.|| .|.  |  .||
lmkkeklslekAlklvkekkpeiepNegFleQLklfek
0043147 (Phosphotyrosine protein) phosphatases II 273-409 2.3e-32 107.5 In-house 21-158 (172) alignment 
Range on Protein: 273-409
Range on HMM: 21-158/172.0
SILPFLFLGSEEGAADEDLIDRLAIKFILNLTPV-CPNFFSEREDIIYKRIQINDSYQEdIGQHFDEAIAFIDE--ARSRGSSVLVHCHAGVSRSATVTV
...........  | . ... .| |. |.|||.  ..  . ||..| | .. . |     . ....|.. ||||  |.|.|  |||||.|||.|..|. .
rfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlva

AYVMQhLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKYEK
|| |. ||||| ||...|.|||| ...| ...  |...||
aylml.lglsleeavalvrekRpgavqnpsqyrflyyfek
0036282 (Phosphotyrosine protein) phosphatases II 273-408 7.6e-27 89.5 In-house 14-166 (174) alignment 
Range on Protein: 273-408
Range on HMM: 14-166/174.0
SILPFLFLGSEEGAaDEDLIDRLAIKFILNLTPVCPN-------------FFSEREDIIYKRIQINDSYQEDIGQhFDEAIAFIDEARSR--GSSVLVHC
 |.| |..|.   | . ... .| |. ...|.. ...              . ||..| |... . |    |. . ..|.. |..||.|.  |  |||||
yitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHC

HAGVSRSATVTVAYVMQHLGL-SLNEAYQFVKEKR---PTISPNLNFMGHLLKYE
.|||.|..|. .|| | ...| || .|...|.|.|   | . .. ...  | ..|
saGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfe
0049260 (Phosphotyrosine protein) phosphatases II 274-409 2.3e-30 100.7 In-house 11-147 (152) alignment 
Range on Protein: 274-409
Range on HMM: 11-147/152.0
ILPFLFLGSEEGAADEDLIDRLAIKFILNLTPVCPN-FFSEREDIIYKRIQINDSYQEDIGQHFDEAIAFIDE-ARSRGSSVLVHCHAGVSRSATVTVAY
.......|..  | . ... .| |. |..||  ... .. . . | |..... |..  |. |...... ||.. |...|  |||||.|||.|..|. .||
fiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaay

VMQhLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKYEK
 |  ||.|| ||...|.|||| . || ...  |...||
lml.lgvsleeavalvrekRpgavpnpgqlrflyefek
subfamily_DSP3_pd Subfamily DSP3 274-408 1.2e-28 93.8 In-house 14-154 (162) alignment 
Range on Protein: 274-408
Range on HMM: 14-154/162.0
ILPFLFLGSEEGAADEDLIDRLAIKFILNLTPV-------CPNFFSErEDIIYKRIQINDSYQEDIGQHFDEAIAFIDEARSR-GSSVLVHCHAGVSRSA
. | |..| |. | |.. . .| |  .|| .          ..|...  .| |  ....|. . |. ..|..| .||||| |.  . |||||..||||||
vypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykd.leikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsa

TVTVAYVMQHLGLSLNEAYQFVKEKRpTISPNLNFMGHLLKYE
|. .||.| .  ..|.|| . |..|| .| ||  |.  | ...
tlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeld
0037934 (Phosphotyrosine protein) phosphatases II 274-408 1.2e-25 86.0 In-house 42-238 (243) alignment 
Range on Protein: 274-408
Range on HMM: 42-238/243.0
ILPFLFLGSE--------EGAADEDLIDRLAIKFILNLTPVC------------------------------------------PN-FFSEREDIIYKRI
..| |....           |.. ... .| |. |..||. .                                          ..    .|..| | ..
vtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhyl

QIND----SYQEDIGQHFDEAIAFIDE-----ARSRGSSVLVHCHAGVSRSATVTVAYVMQHL-GLSLNEAYQFVKEKRPT-ISPNLNFMGHLLKYE
 . |    .  ||. ...||...||.|     |...|. |||||.|||.|..|. .||.| .| |..| ||.....|.||  . ......  | ...
pwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal
0042113 (Phosphotyrosine protein) phosphatases II 274-408 1e-24 82.8 In-house 50-239 (245) alignment 
Range on Protein: 274-408
Range on HMM: 50-239/245.0
ILPFLFLGSEEGAADED----LIDRLAIKFILNLTPVCP--------------------------------------------NFFSEREDIIYKRIQIN
| | .....   . . .    .. .| |. |..||.  .                                              . .||.| | .. . 
itpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp

DSYQEDIGQHFDEAIAFIDEARS--RGSSVLVHCHAGVSRSATVTVAYVM-----QHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKYE
|    |. ....... |...|..  ..  |||||.|||.|..|. .|| |      .||.|| ||.......|| . ......  | ...
dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
subfamily_STYXL1_pd Subfamily STYXL1 274-409 1.8e-24 79.7 In-house 14-151 (157) alignment 
Range on Protein: 274-409
Range on HMM: 14-151/157.0
ILP-FLFLGSEEGAADEDLIDRLAIKFILNLTPVCPNFFSERED-IIYKRIQINDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVAY
.|| .|.|| .. | .. .   | .|  .|..  . ....  .|     .|...|. . |. ....||. ||.. . .|. |||  . |.||||.| .||
vlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiay

VMQHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKYEK
.| .  ..|..||...|. .. . || .|.  | ..||
lmyskkitlkkaykylkkCkenvkPnrafveqlseWek
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 276-408 3e-32 105.2 In-house 13-144 (148) alignment 
Range on Protein: 276-408
Range on HMM: 13-144/148.0
PFLFLGSEEGAADEDLIDRLAIKFILNLTPVCPNFFSEReDIIYKRIQINDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVAYVMQH
 |||||| . ||| . .  | .  | | |  ..| . .|  | |  ....|  .||. . |...|||...|...|  ||||.. |||||. .........
afLFlGskksaadlealkalgvtrivnatkerdnaldqr.gieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidf

LGLSLNEAYQFVKEKRPTISPNLNFMGHLLKYE
   ||.||...||.||. . ||| |.  | ..|
krvslkealalvkskrryvdpnlgfLkqLaele
subfamily_MKPLT_pd Subfamily MKPLT 277-409 2.8e-28 92.5 In-house 28-158 (164) alignment 
Range on Protein: 277-409
Range on HMM: 28-158/164.0
FLFLGSEEGAADEDLIDRLAIKFILNLTPVCPNFFSEreDIIYKRIQINDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVAYVMQHL
 |.||  . | .| ... | |. |.|..  . . |..   . | .....|  .| ...... |  |. .|   |  |||||  |.|||..||||....  
tlylGnakhatnekvlkdlkithivnvsqekkdafpk..sveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

GLSLNEAYQFVKEKRPTISPNLNFMGHLLKYEK
|  |.|||...||.|  ..||  |.  | |.|.
gwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 277-409 2.8e-28 92.5 In-house 28-158 (164) alignment 
Range on Protein: 277-409
Range on HMM: 28-158/164.0
FLFLGSEEGAADEDLIDRLAIKFILNLTPVCPNFFSEreDIIYKRIQINDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVAYVMQHL
 |.||  . | .| ... | |. |.|..  . . |..   . | .....|  .| ...... |  |. .|   |  |||||  |.|||..||||....  
tlylGnakhatnekvlkdlkithivnvsqekkdafpk..sveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

GLSLNEAYQFVKEKRPTISPNLNFMGHLLKYEK
|  |.|||...||.|  ..||  |.  | |.|.
gwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 277-409 3.1e-27 88.8 In-house 9-150 (154) alignment 
Range on Protein: 277-409
Range on HMM: 9-150/154.0
FLFLGSEEGAADEDLIDRLAIKFILNLTPVCPNFFSER-ED------IIYKRIQINDSYQEDIGQHFDEAIAFIDEAR--SRGSSVLVHCHAGVSRSATV
||...| . | .  ...   || |||     .| |...  |      | | .... |  . || ...| |  |||.|    . . ||||...||||||..
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

TVAYVMQHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKYEK
 ..|.|..| .|| .|....|. |. |.||  |.  | ..||
lisylmdklkislslalellkdsryiikPnqGflkqleifek
0051429 (Phosphotyrosine protein) phosphatases II 277-407 1.4e-20 69.5 In-house 22-220 (272) alignment 
Range on Protein: 277-407
Range on HMM: 22-220/272.0
FLFLGSEE----GAADEDLIDRLAIKFILNLTPVC----PNFFSEREDIIYKRIQINDSYQEDIGQHF--------------------------------
 ... |       ||| . . .| || |..|....     ... . ..| | .. |.|.. ..| ...                                
grlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsageare

----------------DEAIAFIDEARSrGSSVLVHCHAGVSRSATVTVAYVMQhLGLS--------------LNEAYQFVKEKRPTISPNLNFMGHLLK
                .. ...... .. |  |||||.||..|..|| ... .  ||.|              | ||.. ....|| . ..  ..  |..
vmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflye

Y
.
a
DSPc Dual specificity phosphatase, catalytic domain 278-409 2e-41 136.0 Pfam-A 1-132 (133) alignment 
Range on Protein: 278-409
Range on HMM: 1-132/133.0
LFLGSEEGAAdEDLIDRLAIKFILNLTPVCPN-FFSEREDIIYKRIQINDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVAYVMQHL
|.|||.. |  ..|.. | |....|.|  .|| .... ..| | ||...|. ...| ....||..||..|...| .||||| ||.|||||...|| |.  
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GLSLNEAYQFVKEKRPTISPNLNFMGHLLKYEK
.|||||||.||||.|..|||| .|.. ||.||.
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 278-409 2e-41 136.0 In-house 1-132 (133) alignment 
Range on Protein: 278-409
Range on HMM: 1-132/133.0
LFLGSEEGAAdEDLIDRLAIKFILNLTPVCPN-FFSEREDIIYKRIQINDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVAYVMQHL
|.|||.. |  ..|.. | |....|.|  .|| .... ..| | ||...|. ...| ....||..||..|...| .||||| ||.|||||...|| |.  
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GLSLNEAYQFVKEKRPTISPNLNFMGHLLKYEK
.|||||||.||||.|..|||| .|.. ||.||.
nlslneAyefvkerrskispnagflrqLleyer
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 280-409 7.1e-25 80.8 In-house 8-139 (145) alignment 
Range on Protein: 280-409
Range on HMM: 8-139/145.0
LGSEEGAADEDLIDRLAIKFILNLTP--VCPNFFSEREDIIYKRIQINDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVAYVMQHLG
 ||   | |  ... | |  |.|..   .     .  |.|    |  .|    |. |||||   |||  .  |. |.||| |||||| ||.||..|.. .
vgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycn

LSLNEAYQFVKEKRPTISPNLNFMGHLLKYEK
..| || . |. .|    ||..|.  ||. ||
mtlseaarqvrsnrllaypnvtflknllnlek
0040439 (Phosphotyrosine protein) phosphatases II 291-408 7.2e-25 83.4 In-house 73-242 (249) alignment 
Range on Protein: 291-408
Range on HMM: 73-242/249.0
LIDRLAIKFILNLTPVCPNFF-----------------------------------------SEREDIIYKRIQINDSYQEDIGQHFDEAIAFIDEARS-
.. .| |. |..||. ... .                                          . |.. .. ||. |    .. ..|.....||...|. 
mlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrka

-----RGSSVLVHCHAGVSRSATVTVAYVM-----QHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKYE
     .|. |||||.|||.|..|. .|| |      .||..| ||.......|| . .|....  |....
leelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeal
0039614 (Phosphotyrosine protein) phosphatases II 294-408 2.6e-21 71.8 In-house 123-285 (297) alignment 
Range on Protein: 294-408
Range on HMM: 123-285/297.0
RLAIKFILNLTPVC------PNFFSEREDiIYKRIQI-----------------------------------NDSYQEDIGQHFDEAIAFIDEARS---R
.. .. |..||. .      . ...|...  |.....                                    |    .. ....|.. ...||..   .
eqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpk

GSSVLVHCHAGVSRSATVTVAYVM-----QHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKYE
|  |||||.|||.|..|. .|| |      . |... ||.....|.|| . ......  | ...
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydal
subfamily_DSP23_pd Subfamily DSP23 295-393 2.1e-12 41.9 In-house 30-127 (148) alignment 
Range on Protein: 295-393
Range on HMM: 30-127/148.0
LAIKFILNLTPVCPNFFSEREDIIYKRIQINDsYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVAYVMQHLGLSLNEAYQFVKEKRPT
| ..... ||  ..       .. ..|..|.| |.    .  .| .  ..|| ... .| |||  |  |. |.   |.... .|.  ||   |...|| 
lgvrylvslteegrphveatpnltlvrlridd.yhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpg
0045450 (Phosphotyrosine protein) phosphatases II 296-408 1.4e-23 79.5 In-house 131-300 (307) alignment 
Range on Protein: 296-408
Range on HMM: 131-300/307.0
AIKFILNLTPVCPNFF--------------------------SEREDIIYKRIQINDS-----------------YQEDIGQHFDEAIAFIDEARS----
 .. |..||. ... .                          .. ..... .. . |.                    .. ..|.|...||.|.|.    
gvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkalee

--RGSSVLVHCHAGVSRSATVTVAYVMQHLG--------LSLNEAYQFVKEKRPTISPNLNFMGHLLKYE
  .|. |||||.|||.|..|. .||.| ...        ..| ||.....|.|| . .|....  | ...
lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal
subfamily_STYX_pd Subfamily STYX 296-408 1.9e-23 76.4 In-house 45-154 (166) alignment 
Range on Protein: 296-408
Range on HMM: 45-154/166.0
AIKFILNLTPVCPNFfseREDIIYKRIQINDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVAYVMQHLGLSLNEAYQFVKEKRPTIS
 |.  .. . . |||   .... |  ... |.  |.| ... .  .|||.. ..|  ||||  ||.||||.. .||.|.  ||   ||...|.|.|  |.
cirqnieanlikpnf...pdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcin

PNLNFMGHLLKYE
||  |.  | .||
pnegfvsqlkeye
0040438 (Phosphotyrosine protein) phosphatases II 296-407 1.1e-21 72.9 In-house 110-271 (317) alignment 
Range on Protein: 296-407
Range on HMM: 110-271/317.0
AIKFILNLTPVCPN--------------------------FFSeREDIIYKRIQINDS----------------YQEDIGQHFDEAIAFIDEARSR----
 .. |..||. ...                          ..   ..|.. .... |.                   .. ...|. ..|....|.     
gvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedp

GSSVLVHCHAGVSRSATVTVAYVM-----QHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKY
|. |||||.|||.|..|. .||.|     .. |... ||.....|.|| . ......  | ..
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
subfamily_MSG5_pd Subfamily MSG5 296-408 1.3e-18 60.7 In-house 47-157 (165) alignment 
Range on Protein: 296-408
Range on HMM: 47-157/165.0
AIKFILNLTPVCPNFFSEREDIIYKRIQINdsYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVAYVMQHLGLSLNEAYQFVKEKRPTIS
..  ..|..   ...      . |  |. .  ..  | . . .    |  |.|..  .||||  |.||||.. |||.|.. .|||..||. .| .   ||
sfdlvinvakeindlellvpavkyyhiewe..hdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddis

PNLNFMGHLLKYE
|.. ..  |...|
psiglifqlmewe
0036941 (Phosphotyrosine protein) phosphatases II 297-407 1.4e-18 62.7 In-house 103-272 (297) alignment 
Range on Protein: 297-407
Range on HMM: 103-272/297.0
IKFILNLTPV-------CPNFFSER----------------------EDIIYK----------------RIQINDSYQEDIGQHFDEAIAFIDEARS---
.. |..||..       |. ....                       .|...                  ... .    .. ..... ..||...|.   
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlk

---RGSSVLVHCHAGVSRSATVTVAYVM--------QHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKY
   .|. |||||.|||.||.|. .|..|         . |... ||.....|.|| . ..|...  |  .
llpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyea
0043336 (Phosphotyrosine protein) phosphatases II 299-407 5.4e-17 57.6 In-house 115-272 (278) alignment 
Range on Protein: 299-407
Range on HMM: 115-272/278.0
FILNLTPVC---------------------------------------------PNFFseREDIIYKRIQINDSYQE-DIGQHFDEAIAFIDEARSRGSS
 |..||.                                                ..   |.  .|  . . |     .. ...|   |...  ..... 
tivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdges..rtvthyhylgwpdhgvpeslsllldflkavrealedsngp

VLVHCHAGVSRSATVTVAYVM-----QHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKY
|||||.|||.|..|. ..|..      ..|..| ||.....|.|| . ......  | ..
vlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
subfamily_RNGTT_pd Subfamily RNGTT 299-393 8e-07 22.9 In-house 57-156 (189) alignment 
Range on Protein: 299-393
Range on HMM: 57-156/189.0
FILNLTPVCPNFFS---EREDIIYKRIQINDSYQEDIGQHFDEAIAFIDE--ARSRGSSVLVHCHAGVSRSATVTVAYVMQHLGLSLNEAYQFVKEKRPT
....||   . .     |.|.| |...|..   .    .. .| |  ..|  ...  . . |||. |  |.  . |.|....   |...| .  .. || 
lvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRpp
0050432 (Phosphotyrosine protein) phosphatases II 307-398 1.3e-12 43.2 In-house 150-285 (308) alignment 
Range on Protein: 307-398
Range on HMM: 150-285/308.0
CPNFFSER---EDIIYKRIQI----------------------------------NDSYQEDIGQHFDEAIAFIDEARSR--GSSVLVHCHAGVSRSATV
|. .. .    . ..|.....                                   .    .. ..... ..|....|..  |. ..|||.|||.|..|.
caqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtf

TVAYVM-----QHLGLSLNEAYQFVKEKRPTISPNL
 .....     .. |... ||.....|.||   ...
ialdllleqlekeggvdvfeavkklReqRpgmvqtp
PTPlike_phytase Inositol hexakisphosphate 311-373 1.4e-08 29.5 Pfam-A 87-147 (149) alignment 
Range on Protein: 311-373
Range on HMM: 87-147/149.0
FSEREDIIYKRIQINDSYQEDiGQHFDEAIAFIDEArSRGSSVLVHCHAGVSRSATVTVAYVM
..|. .. | || | | .. .  ...|. ...| .. .| ......|.||  |. |..| . .
laegfgvkYvRipitdeqape.eedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadL
PTPlike_phytase Inositol hexakisphosphate 311-373 1.4e-08 29.5 In-house 87-147 (149) alignment 
Range on Protein: 311-373
Range on HMM: 87-147/149.0
FSEREDIIYKRIQINDSYQEDiGQHFDEAIAFIDEArSRGSSVLVHCHAGVSRSATVTVAYVM
..|. .. | || | | .. .  ...|. ...| .. .| ......|.||  |. |..| . .
laegfgvkYvRipitdeqape.eedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadL
0038934 (Phosphotyrosine protein) phosphatases II 313-408 4.3e-20 67.6 In-house 76-173 (194) alignment 
Range on Protein: 313-408
Range on HMM: 76-173/194.0
EREDIIYKRIQINDSYQEDIGQHFDEAIAFIDE--ARSRGSSVLVHCHAGVSRSATVTVAYVMQHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKYE
|. .| | .... | .     .  .. . ..||  ... |  |.|||.||..|..|. .|| ...||.|..||.....|||| . || ...  |||. 
ekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkry
subfamily_Laforin_pd Subfamily Laforin 313-394 5.9e-09 29.0 In-house 73-154 (183) alignment 
Range on Protein: 313-394
Range on HMM: 73-154/183.0
EREDIIYKRIQINDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVAYVMQHLGLSLNEAYQFVKEKRPTI
  | . |  . ..|   |   . . .|. ..     .|  | ||| ||| ||... . ...  || ||.    |.  |||..
keeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv
subfamily_PTPDC1_pd Subfamily PTPDC1 314-393 4.7e-09 30.9 In-house 80-157 (182) alignment 
Range on Protein: 314-393
Range on HMM: 80-157/182.0
REDIIYKRIQINDsYQEDIGQHFDEAIAFIDEARSRGsSVLVHCHAGVSRSATVTVAYVMQHLGLSLNEAYQFVKEKRPT
...|..  . ..| |.    ..  . .  .. | ..|  | ||||||  |   .  .|.. .  |. ..| ..|..||| 
eqgiyvynfgwkD.ygvasleriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpk
subfamily_DSP11_pd Subfamily DSP11 315-392 1.8e-06 21.9 In-house 78-158 (178) alignment 
Range on Protein: 315-392
Range on HMM: 78-158/178.0
EDIIYKRIQIND--SYQEDIGQHFDEAI-AFIDEARSRGSSVLVHCHAGVSRSATVTVAYVMQHLGLSLNEAYQFVKEKRP
|.. |.....      .|.. ..| ||.  |...    .. . |||  || |.  .   |.... |.. ..| .  .| | 
egvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearG
DSPc_SM00195 318-373 8.3e-06 20.7 In-house 159-218 (263) alignment 
Range on Protein: 318-373
Range on HMM: 159-218/263.0
IYKRIQINDSYQEDIGQHFDEAIAFIDEARSRGS----SVLVHCHAGVSRSATVTVAYVM
  . .|...  .... .. .. .... ..... |     ..|||.|||.|..|. .. ..
kvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidii
PTPc_SM00194 318-373 8.3e-06 20.7 In-house 159-218 (263) alignment 
Range on Protein: 318-373
Range on HMM: 159-218/263.0
IYKRIQINDSYQEDIGQHFDEAIAFIDEARSRGS----SVLVHCHAGVSRSATVTVAYVM
  . .|...  .... .. .. .... ..... |     ..|||.|||.|..|. .. ..
kvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidii
subfamily_PTPMT1_pd Subfamily PTPMT1 321-407 8.4e-19 62.6 In-house 78-164 (171) alignment 
Range on Protein: 321-407
Range on HMM: 78-164/171.0
RIQINDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVAYVMQHLGLSLNEAYQFVKEKRPTISPNLNFMGHLLKY
.... |  ..   ..  ... ||.. .|.|..| |||.|| .||||.  .|.|..  ||..|| ...|.||..|  . . .  | .|
qlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqey
subfamily_Dicty-DSP-Subfam1_pd Subfamily Dicty-DSP-Subfam1 324-385 6.8e-06 18.8 In-house 40-101 (128) alignment 
Range on Protein: 324-385
Range on HMM: 40-101/128.0
INDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVAYVMQHLGLSLNEAYQ
. |  .... . . .    .   |     . |||  |. |.  |  .|||...| .|..| .
lsdwsadklpyrirdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkkale
subfamily_Dicty-DSP19-1_pd Subfamily Dicty-DSP19-1 324-385 6.9e-06 18.8 In-house 39-100 (128) alignment 
Range on Protein: 324-385
Range on HMM: 39-100/128.0
INDSYQEDIGQHFDEAIAFIDEARSRGSSVLVHCHAGVSRSATVTVAYVMQHLGLSLNEAYQ
. |  .... . . .    .   |     . |||  |. |.  |  .|||...| .|..| .
lsdwsadklpyrirdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkkale
0051299 (Phosphotyrosine protein) phosphatases II 327-399 4.4e-13 44.8 In-house 192-273 (288) alignment 
Range on Protein: 327-399
Range on HMM: 192-273/288.0
SYQEDIGQHFDEAIAFIDEARSR----GSSVLVHCHAGVSRSATVTVAYVM-----QHLGLSLNEAYQFVKEKRPTISPNLN
    .. ..... ..|. ..|.     |. |.|||.|||.|..|. .....     .. |... ||.....|.|| . ....
wpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpe
Y_phosphatase Protein-tyrosine phosphatase 329-377 4.3e-06 21.7 Pfam-A 145-198 (235) alignment 
Range on Protein: 329-377
Range on HMM: 145-198/235.0
QEDIGQHFDEAIAFIDEARSRG----SSVLVHCHAGVSRSATVTVA-YVMQHLG
.... .. .. . .|.. ...     ..|.||| |||.|..|. .. .....| 
dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle
Y_phosphatase Protein-tyrosine phosphatase 329-377 4.3e-06 21.7 In-house 145-198 (235) alignment 
Range on Protein: 329-377
Range on HMM: 145-198/235.0
QEDIGQHFDEAIAFIDEARSRG----SSVLVHCHAGVSRSATVTVA-YVMQHLG
.... .. .. . .|.. ...     ..|.||| |||.|..|. .. .....| 
dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle
0047943 (Phosphotyrosine protein) phosphatases II 330-402 3.4e-14 48.4 In-house 179-262 (273) alignment 
Range on Protein: 330-402
Range on HMM: 179-262/273.0
EDIGQHFDEAIAFIDEARS------RGSSVLVHCHAGVSRSATVTVAYVM-----QHLGLSLNEAYQFVKEKRPTISPNLNFMG
 .. ..... . ||...|.      ... |.|||.|||.|..|. .....      . |... ||.......|| . ...... 
hgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyr
0046845 (Phosphotyrosine protein) phosphatases II 334-397 1.6e-11 39.6 In-house 182-259 (284) alignment 
Range on Protein: 334-397
Range on HMM: 182-259/284.0
QHFDEAIAFIDEARSR------GSSVLVHCHAGVSRSATVTVAYVMQHL--------GLSLNEAYQFVKEKRPTISPN
....  ..|....|.       |. ..|||.|||.|..|. ..... ..        |... ||.....|.||    .
pspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqt
0048567 (Phosphotyrosine protein) phosphatases II 337-399 1.8e-09 32.1 In-house 61-126 (157) alignment 
Range on Protein: 337-399
Range on HMM: 61-126/157.0
DEAIAFIDEARSRGSSVLVHCHAGV---SRSATVTVAYVMQHLGLSLNEAYQFVKEKRPTISPNLN
  .  |..  . .|  . |||.||    .|.||.  .| . |||.. .||.....  ||.. |   
lklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrd
PTPc_DSPc_SM00012 339-375 9.4e-08 27.6 In-house 22-64 (105) alignment 
Range on Protein: 339-375
Range on HMM: 22-64/105.0
AIAFIDEARSR------GSSVLVHCHAGVSRSATVTVAYVMQH
 . .... ..       ...|.|||.|||.|..|....... .
ilellravkknknksesskpvvVhCsaGvgRtgtfvaldillq
subfamily_CDC14_pd Subfamily CDC14 342-394 1.1e-07 26.0 In-house 255-309 (328) alignment 
Range on Protein: 342-394
Range on HMM: 255-309/328.0
FIDEARSRGSSVLVHCHAGVSRSATVTVAYVMQHLGLSLNEAYQFVKEKRPT--I
|.. | .   .. |||.||. |  |.  .|.|.| ... .||  ...  ||   |
fleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvi
subfamily_PRL_pd Subfamily PRL 347-393 4e-06 20.9 In-house 87-132 (151) alignment 
Range on Protein: 347-393
Range on HMM: 87-132/151.0
RSRGSSVLVHCHAGVSRsATVTVAYVMQHLGLSLNEAYQFVKEKRPT
.. .|.| ||| ||. | | | ||  .   |.. ..| .|..|||  
eepkstvavhcvaGlGr.aPvlvalalieaGmkyedavefirekrrg