Gene DSP11 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP11
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP006_AA protein Get Run
NvecP006_AA_13-184 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0038934 (Phosphotyrosine protein) phosphatases II 3-184 1.3e-48 160.5 In-house 1-174 (194) alignment
Range on Protein: 3-184
Range on HMM: 1-174/194.0
RIPDRWRDYSTCNWtPIEGqRIIIFKTPLSNKYNTSapedngIEENERFTPTDLIEQLAQREMKLGLVLDFTFTTRYYDPREFTAEGIIYKKMMCAGH-V
..||||..|  ... .|.| |.|.||.|||. ...       |||  ||.|.||.. | .. .|||||.|.| |.|||||.||.. || | |... .. .
klPdrwlkyervgd.iitg.rfiafkvPlsgsldky......ieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgt

IPKKKDIKRFEDEVKNFLENDkTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAIEAFNQARGHPLERENYLEDLKKRLK
.|  . ..|| | |. ||..| .| .|..||..|..|||..|..||| ..|. .|.||. |...|.. ... .|||.| || |
vPsleillrfldlvdeflned.pggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkryk

subfamily_DSP11_pd Subfamily DSP11 4-186 4.2e-82 268.3 In-house 1-177 (178) alignment
Range on Protein: 4-186
Range on HMM: 1-177/178.0
IPDRWRDYSTCNwTPIEGQRIIIFKTPLSNKYntsapeDNGIEENERFTPTDLIEQLAQREMKLGLVLDFTFTTRYYDPREFTAEGIIYKKMMCAGHVIP
.||||..|.... . |||.|.|.|||||....      |...||..||||.||.|.|.....|||||.|.| |.|||...|.|.||. |.|..|.||..|
vPdrwkkykpvg.dkiegtrfiafktPlkesf......dkkveeekrftpkdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhevp

KKKDIKRFEDEVKNFLE-NDKTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAIEAFNQARGHPLERENYLEDLKKRLKDS
|.. .|.|...||.||| |.....|.|.|||||||||||..||||||..|||||.|||||..||||.|||||||.||||. || 
keelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkklekdk

subfamily_RNGTT_pd Subfamily RNGTT 5-186 1.1e-44 146.4 In-house 1-174 (189) alignment
Range on Protein: 5-186
Range on HMM: 1-174/189.0
PDRWRDYSTCNwTPIEgQRIIIFKTPLSNKYNTSapedngIEENERFTPTDLIEQLAQREMKLGLVLDFTFTTRYYDPREFTAEGIIYKKMMCAGHVI-P
|.||..      . |. .. . ||||||..|. .      . |..||.|. |.. |  ...|||||.|.| |.|||| .|.. ||| |.|. |||.   |
PerWlnCPrkg.klia.ekflpfktplskryddd......laeenrfepsmllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaP

KKKDIKRFEDEVKNFLEnDKTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAIEAFNQARGHPLERENYLEDLKKRLKDS
.. ..|.|   |..| . ... ...|.||||| ||||.... ||..   .. |.|...|..||   . .|.||..| .| .|.
eaeqvkefiklveeffk.knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellrrYadv

0036282 (Phosphotyrosine protein) phosphatases II 6-180 1.8e-25 85.0 In-house 2-163 (174) alignment
Range on Protein: 6-180
Range on HMM: 2-163/174.0
DRWRDYSTCNWTPIEGqRIIIFKTPLSnkyntsapednGIEENERFTPTDLIEQLAQREMKLGLVLDFTFTTRYYdpreFTAEGIIYKKMMCAGHVIPKK
... ..| .... | . |.|... ||.            .|.  ..  |...  |  .|..|... ... ..|..    .. .|| |..... .|  |  
sdyinaspldlsyitp.rliagqgpla...........fwemlkelgittvvmlleekelglykcinywpelred....lerlgiqylylpwpDhgvpdl

KDIKRFEDEVKNFLENdKTGSLVGIHCTHGVNRTGYMVCRYLIDCCGY-EPEKAIEAFNQAR---GHPLERENYLEDLK
  . .| ..|...|.. . |  | .||..||.|||..|. ||. ....  ...|.. . ..|   ..  ....... | 
sillefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrfly

0037934 (Phosphotyrosine protein) phosphatases II 9-179 3.1e-19 64.9 In-house 32-234 (243) alignment
Range on Protein: 9-179
Range on HMM: 32-234/243.0
RDYSTCNWTPIEGqRIIIFKTPLSNkyntsapedngieenerfTPTD----LIEQLAQRemKLGLVLDFTFTT---------------------------
 ||   |.... . |.|..  ||..                  |  |     .. | .   . . ....| ..                           
sdyinanliyvtp.rliatqgPlpe..................tveddlasfwrmlwel..gitvivmltelvElgrekcaqywpgevtygdftvtllse

-------------RYYDPREFTAEGIIYKKMMCAGHVIPK-KKDIKRFEDEVKNFLEN------DKTGSLVGIHCTHGVNRTGYMVCRYLIDCC-GYEPE
             ...|. ..| ..| |  .   .| .|   .|. .| |||..|.|.      ...|. | .||..||.|||.... ||.  . |. .|
ehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdle

KAIEAFNQARGH-PLERENYLEDL
.|.. . . |..   . ..... |
eavkllreqRpgkavqtpsqyrfl

0046845 (Phosphotyrosine protein) phosphatases II 10-172 4.2e-13 44.8 In-house 58-259 (284) alignment
Range on Protein: 10-172
Range on HMM: 58-259/284.0
DYSTCNWTP-------IEGQRIIIFKTPLSN-----------------------------KYNTSAPEDNGIEENERFTPTDLIEQLaqreMKLGLVLDF
||   .. .       .  ...|....||.|                             |.    |....  . ..|| | | |.     ..   |  .
dYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseev....kddytvrtl

TFTTRYYDPREFTAEGIIYKKMMcAGHVIPKKKDIKRFEDEVKNFLENDKTGSLVGIHCTHGVNRTGYMVCRYLIDCC--------GYEPEKAIEAFNQA
. |   |.  ..|   . |..     .| |  .|. .| ..|...||| ..|. . .|| .||.|||.... .|. ..        |. ...|.  . . 
eltnlgytgesrtvthfhytswp.dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreq

RGHPLER
| .  . 
Rpgmvqt

0040439 (Phosphotyrosine protein) phosphatases II 15-180 1.4e-21 72.7 In-house 45-239 (249) alignment
Range on Protein: 15-180
Range on HMM: 45-239/249.0
NWTPI--EGQRIIIFKTPLSNkyntsapedngieenerfTPTDLIEQLAQRemKLGLVLDFTFTTRY---------------------------------
.. .    ..|.|....||..                  |  | ...| .   . . ....| ....                                 
syidgyyikrrfiatqgPlpe..................tvedfwrmlwel..gitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddy

----------YDPREFTAEGIIYKKMMcAGHVIPKKKDIKRFEDEVKNFLENDKTGSLVGIHCTHGVNRTGYMVCRYLI-----DCCGYEPEKAIEAFNQ
          ||. ..|  .| | ..    .| |  .|. .| ..|...||....|. | .||..||.|||.... ||.       .|. .| |.. ...
tvrtleltnlydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrs

ARGHPLERENYLEDLK
.|..  . ..... | 
qRpgavqnpeqyrfly

0045450 (Phosphotyrosine protein) phosphatases II 18-180 8.1e-18 60.6 In-house 103-297 (307) alignment
Range on Protein: 18-180
Range on HMM: 103-297/307.0
PIEGQRIIIFKTPLSNkyntsapedngieenerfTPTDLIEQLAQRemKLGLVLDFTFTT--------RYYdPRE-------------------------
.. ....|....||..                  |. | ...| .   . ..... | ..        .|. | |                         
ydlkrkfIatqgPlpe..................tvedFwrmlweq..gvtvivmltelvelgrekcaqyw.Pdegeeltygnftvtllseehldgytvr

--------FTAEGIIYKKMMC---AGHVIP-KKKDIKRFEDEVKNFLENDKTGSLVGIHCTHGVNRTGYMVCRYLIDCCG--------YEPEKAIEAFNQ
        .| |... . . .    .| .|   ... .| .||...||... |. | .||..||.|||.... ||. ...        . ...|.. . .
tlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllre

ARGHPLERENYLEDLK
 |..  . ..... | 
qRpgavqnpeqyrfly

0040438 (Phosphotyrosine protein) phosphatases II 19-177 4.8e-17 57.6 In-house 81-266 (317) alignment
Range on Protein: 19-177
Range on HMM: 81-266/317.0
IE--GQRIIIFKTPLSNkyntsapedngieenerfTPTDLIEQLAQRemKLGLVLDFTFTTRYYD----------------------PREFTAEGIIYKK
.   ....|....||.|                  |  | .. . .   ...... .| .. . .                        |.. .||.. .
gpnlkrkfIatqgPlpn..................tvedFwrmvweq..gvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrt

MMC-------------------AGHVIP-KKKDIKRFEDEVKNFLEndKTGSLVGIHCTHGVNRTGYMVCRYLI-----DCCGYEPEKAIEAFNQARGHP
...                     | .|   ... .| ..|...||  . |. | .||..||.|||.... ||.       .|. .|.|.. ....|.. 
levedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpga

LERENYLE
 . .....
vqtpeqyr

0042113 (Phosphotyrosine protein) phosphatases II 20-180 2.8e-17 58.4 In-house 50-236 (245) alignment
Range on Protein: 20-180
Range on HMM: 50-236/245.0
EGQRIIIFKTPLSNkyntsapedngieenerfTPTDLIEQLAQRemKLGLVLDFTFTTRYYD--------------------------------------
  ...|..  ||..                  |. | ...| .   ..  ....| .. .                                        
itpkfiatqgPlpe..................tvedfwrmlwel..gittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlev

---PREFTAEGIIYKKMMCAGHVIPK-KKDIKRFEDEVKNFLENdKTGSLVGIHCTHGVNRTGYMVCRYLI-----DCCGYEPEKAIEAFNQARGHPLER
   .  .. |.| |  . . .| .|   ... .| ..|...|.. . .  | .||..||.|||.... ||.       .|. .|.|.. ... |..  . 
tnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqt

ENYLEDLK
..... | 
psqyrfly

0041856 (Phosphotyrosine protein) phosphatases II 21-176 4.9e-22 73.8 In-house 33-160 (182) alignment
Range on Protein: 21-176
Range on HMM: 33-160/182.0
GQRIIIFKTPLSNkyntsapedngieenerfTPTDLIEQLAQRemKLGLVLDFTftTRYYDPREFTAEGIIYKKMMCAGHVIPKKKDIKRFEDEVKNfle
..|.|....|| .                  |. | ...| ..  . ..... |   ..|.| ... .|| |... . .| .|   .. .| .||..   
atrfiatqgplls..................tvadflrmlkel..gittivnlt..eelywpellerlgiqylylpwpDhgvpdldelldfieevle...

ndkTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAIEAFNQARGHPLERENYL
    |  | .||..||.|||..|. ||. ..|. .|.|.. ....| .  ...|..
...eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqy

0043336 (Phosphotyrosine protein) phosphatases II 21-177 9.3e-16 53.6 In-house 87-267 (278) alignment
Range on Protein: 21-177
Range on HMM: 87-267/278.0
GQRIIIFKTPLSNkyntsA---------------------PEDNGIEENERFTPtD--------LIEQLAQREMKLGLVLDFTFTTRYYDPReFTAEGII
....|....||..                           ....| .   .. | .         .. | . ...   | ... | .....  .|  .. 
prkfiatqgPlpe.....tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyh

YKKMMcAGHVIPKKKDIKRFEDEVKNFLEndKTGSLVGIHCTHGVNRTGYMVCRYLI-----DCCGYEPEKAIEAFNQARGHPLERENYLE
|....  ..| .  ... .|  .|...||  . .. | .||..||.|||.... ||.     . .|. .|.|.. ... |.. .. .....
ylgwp.dhgvpeslsllldflkavreale..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyr

0039614 (Phosphotyrosine protein) phosphatases II 21-176 5.1e-15 51.2 In-house 100-278 (297) alignment
Range on Protein: 21-176
Range on HMM: 100-278/297.0
GQRIIIFKTPLSNkyntsapedngieenerfTPTDLIEQLAQRemKLGLVLDFTFTTRY--------------------YDPREFTAEGII---------
....|....||..                  |. | .. . .   .   ..  | .. .                    .  .... .|..         
trkfIatqgPlpe..................tvedFwrmvweq..gvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnn

----------YKKMMcAGHVIPKKKDIKRFEDEVKNFLENDKTGSLVGIHCTHGVNRTGYMVCRYLI-----DCCGYEPEKAIEAFNQARGHPLERENYL
          | ..   ..| |  ... .| ..|...|.... |  | .||..||.|||.... ||.       .|. ...|.. ....|..  . ....
gesrtvthfqytgwp.dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqy





PTEN_1 40-178 6.1e-20 66.9 In-house 44-187 (196) alignment
Range on Protein: 40-178
Range on HMM: 44-187/196.0
PEDNGIEENERFTPTDLIEQLAQR-EMKLGLVLDFTFTTRYYDPREFTAEGIIYKKMMCAGHVIPKKKDIKRFEDEVKNFLENDKTGSLVGIHCTHGVNR
 ... ....... . || .. ..   . . | ...   .| ||..|| ..|..|....   |  |    . .. ..... | .|. |  | .||..|..|
ideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgR

TGYMVCRYLIDCCGYEPEKAIEAFNQARGHPL----ERENYLED
.| .|. ||. . .. ...|.| ....| .      ..| .|| 
sGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlley

subfamily_PTEN_pd Subfamily PTEN 46-167 8.4e-13 43.7 In-house 40-157 (184) alignment
Range on Protein: 46-167
Range on HMM: 40-157/184.0
EENERFTPTDLIEQLAQREMKLGLVLDFTfTTRYYDPREFTAEGIIYkkmMCAGHVIPKKKDIKRFEDEVKNFLENDKTgSLVGIHCTHGVNRTGYMVCR
|.. | . .|... | ..  .   ..... . |.|| ..|. . ..|    .  |  |. . .... ......||.||.  .| .||  |  ||| ... 
ealyRnsledvvkflekkhkdhykiynlr.serkydskkfdgrvavy...pfdDhnppplelleeivediekwleedkk.nvvvvHCkaGkGRtGvliva

YLIDCCGYEPE-KAIEAFNQARG
||. .. .| . .|.| |..|| 
yllkslllekaeealelfaeaRt

0043147 (Phosphotyrosine protein) phosphatases II 50-177 1e-19 66.4 In-house 30-151 (172) alignment
Range on Protein: 50-177
Range on HMM: 30-151/172.0
RFTPTDLIEQLAQREMKLglVLDFTftTRYYDPREFTAEGIIYKKMMCAGHVIPKKKDIKRFEDEVKNFLeNDKTGSLVGIHCTHGVNRTGYMVCRYLID
|.|  | ...| ..  ..  ... |  ...|||  .. .|| |  . .  |  |  . . .| . ....| . . |  | .||..||.|||..|. ||. 
rntladfwrmlkelgith..ivnlt..ellydpellerlgiqylylpwpDhgvpllellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml

cCGYEPEKAIEAFNQARGHPLERENYLE
 .|. .|.|.. . ..|..  . .... 
.lglsleeavalvrekRpgavqnpsqyr

subfamily_CDC14_pd Subfamily CDC14 51-156 2.5e-08 28.1 In-house 199-294 (328) alignment
Range on Protein: 51-156
Range on HMM: 199-294/328.0
FTPTDLIEQLAQREMKLGLVLDftftTRYYDPREFTAEGIIYKKMMCAGHVIPKKKDIKRFEDEVKNFlendkTGSlVGIHCTHGVNRTGYMVCRYLIDC
 .|  |.|  ......  . |.     . || ..||..|. .| .. .   .|... .|.| . ...      .|. . .||  |. ||| ..  ||.  
haPeklleyfrknnvttvvrLn....kklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGa.iavhCkaGLGrtGtLiacylmkh

CGYEPE
 ..  .
yrftaa

0051082 (Phosphotyrosine protein) phosphatases II 55-168 4.5e-16 54.3 In-house 24-134 (151) alignment
Range on Protein: 55-168
Range on HMM: 24-134/151.0
DLIEQLaqREMKLGLVLDFTFTT-RYYDPREFTAEGIIYKKMMCAGHVIPKK----KDIKRFEDEVKNflendKTGSLVGIHCTHGVNRTGYMVCRYLID
| .|.|  .|...  ..... .. |.|.|. ....|| .. . . ..  |.     . ...| ... .     | .  | .||..|..||| .|. ||. 
dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylml

cCGYEPEKAIEAFNQARGH
 .|. .|.|.| . . |..
.lgvsleealeeyrlkrpg

0045098 (Phosphotyrosine protein) phosphatases II 56-169 4.9e-12 41.3 In-house 122-254 (278) alignment
Range on Protein: 56-169
Range on HMM: 122-254/278.0
LIEQLAQREMKLGLVLDFTFTTRYYDPREFTAEGIIYKKM-MCAGHVIPKKK---DIKRFEDEVKNFLE-----------NDKTGSLVGIHCTHGVNRTG
 .. |   ...   . ... |  .. . ...  |. . ..     | .|       . .. ......|.            .  |  | .|| .||.|||
tvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtG

YMVCRYLIDCC---GYEPEKAIEAFNQARGH-P
 .|. ||. ..   |. ...|.. . . |..  
tlvaaylmlelleggvdlleavkelrsqRpgla

0048179 (Phosphotyrosine protein) phosphatases II 59-180 1.4e-19 65.7 In-house 22-138 (144) alignment
Range on Protein: 59-180
Range on HMM: 22-138/144.0
QLAQREMKLGLVLDFTFTtryYDPREFTAEGIIYKKMMCAGHVIPKK-KDIKRFEDEVKNFLEndkTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEK
    .......|...| .   |.| ... ||| | .. . .| .|   ... .| . ....||    |  | .||..||.|||..|. ||. ..|. .|.
lellkklgittvinltee...yepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmkklglslee

AIEAFNQARGHPLERENYLEDLK
|.. . ..| .  . ...|. |.
alalvrsrrpgavpnpgqlrfLl

0049772 (Phosphotyrosine protein) phosphatases II 61-181 6.7e-21 70.8 In-house 167-268 (314) alignment
Range on Protein: 61-181
Range on HMM: 167-268/314.0
AqremklglvldftftTRYYDPREFTAEGIIYKKMMCAGHVIPKKKDIKRFEDEVKNFlendKTGSLVGIHCTHGVNRTG-YMVCRYLIDCCGYEPEKAI
                ...|||  |. .|| |. . . ..  |  .|...| . ....    ..|. | .||..|..||| ..|. ||. ..|. .|.|.
k...............eelydpelferlgikylripvpDgsaplledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleeal

EAFNQARGhPLERENYLEDLKK
| . ..|     .....| |. 
edvrlkRp.inpnpgfieqleq

0048076 (Phosphotyrosine protein) phosphatases II 61-182 5.1e-19 63.8 In-house 24-138 (145) alignment
Range on Protein: 61-182
Range on HMM: 24-138/145.0
AQREMKLGLVLDFtfttrYYDPREFTAEGIIYKKMMCAGHVIPKK-KDIKRFEDEVKNFLENDktgSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAI
  .......||..      .... ....|| |  . . .| .|   ... .| . ....|...     | .||..||.|||..|. ||. ..|. .|.|.
llkdlgittvlnl.....tselellerlgiqylylpwpDhgvpdllellleflefieealkeg...gpvlVHCsaGvgRtgtlvaaylmlllgvsleeal

EAFNQARGHPLERENYLEDLKKR
| . ..| .  .....|. |.. 
elvrsqrpgavpnpgqlrflyef

subfamily_DSP10_pd Subfamily DSP10 62-158 7.2e-07 23.2 In-house 35-125 (159) alignment
Range on Protein: 62-158
Range on HMM: 35-125/159.0
QREMKLGLVLDFTFTTryydPREFTAEGIIYKKMMCAGHvipKKKDIKRFEDEVKNFLEN-DKTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKA
 .....  ||. | ..    | ||. |.. ||..        .|...|.  .|  .|.|.  |.|| | .||  |. |   .|  ||.   .   ..|
ldrlnitavlnvttsv....PnefeeealkYkripvsDt...skqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslnda

0044763 (Phosphotyrosine protein) phosphatases II 63-181 2.4e-20 68.3 In-house 45-165 (178) alignment
Range on Protein: 63-181
Range on HMM: 45-165/178.0
REMKLGLVLDFTFTTRYY----DPREFTAEGIIYKKMMCAGHVIPK-KKDIKRFEDEVKNFLEndKTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEK
.|.........| .....    ||  .. .|| |... . .|  |   . . .| . ....|.  . |. | .||..||.|.|..|. ||. ..|. .|.
kelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkklglslee

AIEAFNQARGhPLERENYLEDLKK
||| . ..|    .....|. |..
aielvrerRp.ivpnpgqlrqLye

0051429 (Phosphotyrosine protein) phosphatases II 63-174 4.7e-10 35.1 In-house 42-212 (272) alignment
Range on Protein: 63-174
Range on HMM: 42-212/272.0
REMKLGLVLDFTFTTR-YYDPREFTAEGIIYKKMMCAGHVIPKK----------------------------------------------------KDIK
.|...  ..|.. ..   ... .. ..|| |  . . ... |                                                      . ..
kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeall

RFEDEVKNflendktGSLVGIHCTHGVNRTGYMVCRYLIDcCGYE--------------PEKAIEAFNQARGHPLEREN
.. ... .       |  | .||..|..||| .|. .|.   | .              .|.|.|   ..| .  . | 
ellellld.......ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqtee

0049260 (Phosphotyrosine protein) phosphatases II 65-180 2.2e-19 65.1 In-house 30-143 (152) alignment
Range on Protein: 65-180
Range on HMM: 30-143/152.0
MKLGLVLDFTFTTRYYDPREFTAEGIIYKKMMCAGHVIPKKKDIKRFEDEVKNFLeNDKTGSLVGIHCTHGVNRTGYMVCRYLIDcCGYEPEKAIEAFNQ
 .||     . |.............| |. . .  |  |.  .. .|  .. ..| . . |  | .||..||.||| .|. ||.  .|...|.|.. . .
kelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvre

ARGHPLERENYLEDLK
.| .  . ...|. |.
kRpgavpnpgqlrfly

0046846 (Phosphotyrosine protein) phosphatases II 66-177 1.2e-16 56.4 In-house 47-163 (176) alignment
Range on Protein: 66-177
Range on HMM: 47-163/176.0
KLGLVLDFTFTT------RYYDPREFTAEGIIYKKMMCAGHVIPKKKDIKRFEDEVKNFLENDktgSLVGIHCTHGVNRTGYMVCRYLIDC-CGYEPEKA
. ..|...|  .       .... |....|| |. .    | .|  ... .. ......|...     | .|| .|..||| .|. ||. . .|. .|.|
gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeg...gpvlVHCsaGigRtgtlvaayllelekglsveea

IEAFNQARG-HPLERENYLE
.. . . |  . .. .....
lalvreqRplgavqtpeQyr

subfamily_Auxilin_pd Subfamily Auxilin 73-167 1.1e-06 21.4 In-house 54-145 (166) alignment
Range on Protein: 73-167
Range on HMM: 54-145/166.0
FTFTTRYYDPREFTAEGIIYKkmmCAGHVIPKKKDIKRFEDEVKNFLENDKTGSLVgIHCTHGVNRTGYMVCRYLIDCCGY-EPEKAIEAFNQARG
. .. | |.. ....  . ..   .. . .|. . . .   .. ..|..|.   .| .||. |.  .. .|. .|. |  . |||.|.. |.  | 
ynlsqrtyrtaklssrvveag...wparraPnLeslvevcrnlyswlkkdpknvvv.vhckDGraasavlvsallvfcrllsepesavrlfsvkrl

0048567 (Phosphotyrosine protein) phosphatases II 74-168 2.6e-12 41.4 In-house 22-120 (157) alignment
Range on Protein: 74-168
Range on HMM: 22-120/157.0
TFTTRYYDPREF-TAEGIIYKKMMCAGHvIPKKKDIKRFEDEVKNFLE-NDKTGSLVGIHCTHGV---NRTGYMVCRYLIDCCGYEPEKAIEAFNQARGH
  ....|..  | . .|..|  .       ..   . ||   ...||.  ...|  . .||..|     ||..... ||| ..|. ||.||. . ..| .
rlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpg





subfamily_VSP_pd Subfamily VSP 76-166 1.1e-12 42.3 In-house 83-170 (212) alignment
Range on Protein: 76-166
Range on HMM: 83-170/212.0
TTRYYDPREFTAEgiiYKKMMCAGHVIPKKKDIKRFEDEVKNFLENDKTgSLVGIHCTHGVNRTGYMVCRYLIDCCGYEP-EKAIEAFNQAR
. | ||.. |  .    |...   | .|| ...  |  |||..||.|.   .. |||  | .||| .|| .|.    .|  ..... | . |
seraydekyfnnr...vkriliddhnvpkleellvftkevkewlekdlk.nvlaihckGGkgrtGtivcalllaseifetakesldyfgerr

subfamily_DSP23_pd Subfamily DSP23 76-168 6e-08 27.5 In-house 39-127 (148) alignment
Range on Protein: 76-168
Range on HMM: 39-127/148.0
TTRYYdPREFTAEGIIYKKMMCAGHVIPKKKDIKRFedeVKNFLENDKTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAIEAFNQARGH
|..   |.  .. .. ....    .  |  .....|   |.   | .. .  |..||  |  ||| |.  ||.   .    .||    . |  
teegr.phveatpnltlvrlriddyhppaleqvvef...vrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpg

subfamily_PRL_pd Subfamily PRL 78-183 2.2e-08 28.3 In-house 44-149 (151) alignment
Range on Protein: 78-183
Range on HMM: 44-149/151.0
RYYDPREFTAEGIIYKKMMCAGHVIPKKKDIKRFEDEVKNFLENdKTGSLVGIHCTHGVNRTGYMVCRYLIDcCGYEPEKAIEAFNQARGHPLERE--NY
  || ... .|||  . .  .    | .. .... . .|.  .. ...| |..||  |. |.  .|.  ||. .| ..|.|.|   . |   ....  ..
ptydteklekegievldlafddGavPpeevveeWlellkekfke.epkstvavhcvaGlGraPvlvalalie.aGmkyedavefirekrrgainskqlkf

LEDLKKRL
||. |.. 
lekykakk

subfamily_PTPDC1_pd Subfamily PTPDC1 80-177 2.6e-08 28.5 In-house 73-166 (182) alignment
Range on Protein: 80-177
Range on HMM: 73-166/182.0
YDPREFTAEGIIYKKMMCAGHVIPKkkdIKRFEDEVKNFLENDKTGsLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAIEAFNQARGHPLERENYLE
||. .....||.. ..  . .  .    ..|  | ||      . |  |..||  |  ||| ... ||.    ...||||.   . | . ..  . .|
YdlealmeqgiyvynfgwkDygvas...leriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqve

subfamily_PTPMT1_pd Subfamily PTPMT1 81-174 1.3e-06 23.0 In-house 65-156 (171) alignment
Range on Protein: 81-174
Range on HMM: 65-156/171.0
DPREFTAEGIIYKKMMCAGHVipKKKDIKRFEDEVKNFLENDKTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAIEAFNQARGHPLEREN
  .|.. .|. . ..    .   .. |... |. |.   .  ..|. | .||  |  |.. .|  ||.     .||.|..| .. | . . ...
steewkklgveqlqlatvDft..eapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakk

0051299 (Phosphotyrosine protein) phosphatases II 90-170 1.7e-08 29.7 In-house 187-269 (288) alignment
Range on Protein: 90-170
Range on HMM: 187-269/288.0
IIYKKMMcAGHVIPKKKDIKRFEDEVKNFLEndKTGSLVGIHCTHGVNRTGYMVCRYLI-----DCCGYEPEKAIEAFNQARGHPL
. |..     .| .  ... .|  .|...|.  ..|. | .|| .||.||| ... .|.        | ....|.. . . | .  
fhytnwp.dhgvpdspellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmv

PTPc_DSPc_SM00012 97-151 3.3e-09 32.3 In-house 10-65 (105) alignment
Range on Protein: 97-151
Range on HMM: 10-65/105.0
CAGHVIPK-KKDIKRFEDEVKNFLENDKTGSLVGIHCTHGVNRTGYMVCRYLIDCC
.  | .|.  ..| .. ..||.. .. .... | .|| .||.|||..|. ... . 
wpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqq

0047943 (Phosphotyrosine protein) phosphatases II 98-171 1.6e-10 36.4 In-house 178-256 (273) alignment
Range on Protein: 98-171
Range on HMM: 178-256/273.0
AGHVIPKKKDIKRFEDEVKNFLENDKTGSLVGIHCTHGVNRTGYMVCRYLI-----DCCGYEPEKAIEAFNQARGHPLE
  .| |  ... .| ..|...||... .. | .|| .||.||| ... .|.        |  ...|.  . . | .  .
dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvq

DSPc Dual specificity phosphatase, catalytic domain 99-179 2.7e-14 48.1 Pfam-A 49-127 (133) alignment
Range on Protein: 99-179
Range on HMM: 49-127/133.0
GhviPKKKDIKRFEDEVKNFLEN-DKTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAIEAFNQARGHPLERENYLEDL
     ....| .. .|...|.|. .. |  | .||..|..|.......||..  ... ..|.|.... |..  .....|  |
d...etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqL

DSPc Dual specificity phosphatase, catalytic domain 99-179 2.7e-14 48.1 In-house 49-127 (133) alignment
Range on Protein: 99-179
Range on HMM: 49-127/133.0
GhviPKKKDIKRFEDEVKNFLEN-DKTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAIEAFNQARGHPLERENYLEDL
     ....| .. .|...|.|. .. |  | .||..|..|.......||..  ... ..|.|.... |..  .....|  |
d...etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqL

0050432 (Phosphotyrosine protein) phosphatases II 100-171 1.2e-08 30.2 In-house 211-283 (308) alignment
Range on Protein: 100-171
Range on HMM: 211-283/308.0
HVIPKKKDIKRFEDEVKNFLendkTGSLVGIHCTHGVNRTGYMVCRYLI-----DCCGYEPEKAIEAFNQARGHPLE
.| |. ... .| ..|...|     |. . .|| .||.||| ... .|.       .|  ...|.  . . | .  .
gvPpspeilldflelvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvq

0036941 (Phosphotyrosine protein) phosphatases II 101-171 1.8e-09 32.8 In-house 183-261 (297) alignment
Range on Protein: 101-171
Range on HMM: 183-261/297.0
VIPKKKDIKRFEDEVKNFLENDKTGSLVGIHCTHGVNRTGYMVCRYLI--------DCCGYEPEKAIEAFNQARGHPLE
| .  ... .| ..|...|..   |. | .|| .||.|.| ... .|.          .|. . .|.  . . | .  .
vpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavq

PTPc_motif_SM00404 103-181 6.7e-14 47.0 In-house 57-136 (140) alignment
Range on Protein: 103-181
Range on HMM: 57-136/140.0
PKKKDIKRFEDEVKNFLEN-DKTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAIEAFNQARGHPLERENYLEDLKK
 .|... .. |.|..|.||  |.|  | .||..||.|...... ||..  ... ..|.|.... | .  ...|... | .
nekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLie

subfamily_DSP12_pd Subfamily DSP12 105-181 6.2e-07 23.9 In-house 61-138 (155) alignment
Range on Protein: 105-181
Range on HMM: 61-138/155.0
KKDIKRFEDEVKNFLENDK-TGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAIEAFNQARGHPLERENYLEDLKK
..|| .. ||. .|.|.   ..  | .||. || |   .|  ||.   . . |||... .... .    |..|| || 
eediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLkl