Gene DSP11 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP11
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP006_AA protein Get Run
NvecP006_AA_13-184 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0038934 (Phosphotyrosine protein) phosphatases II 3-184 1.3e-48 160.5 In-house 1-174 (194) alignment 
Range on Protein: 3-184
Range on HMM: 1-174/194.0
RIPDRWRDYSTCNWtPIEGqRIIIFKTPLSNKYNTSapedngIEENERFTPTDLIEQLAQREMKLGLVLDFTFTTRYYDPREFTAEGIIYKKMMCAGH-V
..||||..|  ... .|.| |.|.||.|||. ...       |||  ||.|.||.. | .. .|||||.|.| |.|||||.||.. || | |... .. .
klPdrwlkyervgd.iitg.rfiafkvPlsgsldky......ieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgt

IPKKKDIKRFEDEVKNFLENDkTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAIEAFNQARGHPLERENYLEDLKKRLK
.|  . ..|| | |. ||..| .| .|..||..|..|||..|..||| ..|. .|.||. |...|.. ... .|||.| || |
vPsleillrfldlvdeflned.pggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkryk
subfamily_DSP11_pd Subfamily DSP11 4-186 4.2e-82 268.3 In-house 1-177 (178) alignment 
Range on Protein: 4-186
Range on HMM: 1-177/178.0
IPDRWRDYSTCNwTPIEGQRIIIFKTPLSNKYntsapeDNGIEENERFTPTDLIEQLAQREMKLGLVLDFTFTTRYYDPREFTAEGIIYKKMMCAGHVIP
.||||..|.... . |||.|.|.|||||....      |...||..||||.||.|.|.....|||||.|.| |.|||...|.|.||. |.|..|.||..|
vPdrwkkykpvg.dkiegtrfiafktPlkesf......dkkveeekrftpkdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhevp

KKKDIKRFEDEVKNFLE-NDKTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAIEAFNQARGHPLERENYLEDLKKRLKDS
|.. .|.|...||.||| |.....|.|.|||||||||||..||||||..|||||.|||||..||||.|||||||.||||. || 
keelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkklekdk
subfamily_RNGTT_pd Subfamily RNGTT 5-186 1.1e-44 146.4 In-house 1-174 (189) alignment 
Range on Protein: 5-186
Range on HMM: 1-174/189.0
PDRWRDYSTCNwTPIEgQRIIIFKTPLSNKYNTSapedngIEENERFTPTDLIEQLAQREMKLGLVLDFTFTTRYYDPREFTAEGIIYKKMMCAGHVI-P
|.||..      . |. .. . ||||||..|. .      . |..||.|. |.. |  ...|||||.|.| |.|||| .|.. ||| |.|. |||.   |
PerWlnCPrkg.klia.ekflpfktplskryddd......laeenrfepsmllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaP

KKKDIKRFEDEVKNFLEnDKTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAIEAFNQARGHPLERENYLEDLKKRLKDS
.. ..|.|   |..| . ... ...|.||||| ||||.... ||..   .. |.|...|..||   . .|.||..| .| .|.
eaeqvkefiklveeffk.knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellrrYadv
0036282 (Phosphotyrosine protein) phosphatases II 6-180 1.8e-25 85.0 In-house 2-163 (174) alignment 
Range on Protein: 6-180
Range on HMM: 2-163/174.0
DRWRDYSTCNWTPIEGqRIIIFKTPLSnkyntsapednGIEENERFTPTDLIEQLAQREMKLGLVLDFTFTTRYYdpreFTAEGIIYKKMMCAGHVIPKK
... ..| .... | . |.|... ||.            .|.  ..  |...  |  .|..|... ... ..|..    .. .|| |..... .|  |  
sdyinaspldlsyitp.rliagqgpla...........fwemlkelgittvvmlleekelglykcinywpelred....lerlgiqylylpwpDhgvpdl

KDIKRFEDEVKNFLENdKTGSLVGIHCTHGVNRTGYMVCRYLIDCCGY-EPEKAIEAFNQAR---GHPLERENYLEDLK
  . .| ..|...|.. . |  | .||..||.|||..|. ||. ....  ...|.. . ..|   ..  ....... | 
sillefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrfly
0037934 (Phosphotyrosine protein) phosphatases II 9-179 3.1e-19 64.9 In-house 32-234 (243) alignment 
Range on Protein: 9-179
Range on HMM: 32-234/243.0
RDYSTCNWTPIEGqRIIIFKTPLSNkyntsapedngieenerfTPTD----LIEQLAQRemKLGLVLDFTFTT---------------------------
 ||   |.... . |.|..  ||..                  |  |     .. | .   . . ....| ..                           
sdyinanliyvtp.rliatqgPlpe..................tveddlasfwrmlwel..gitvivmltelvElgrekcaqywpgevtygdftvtllse

-------------RYYDPREFTAEGIIYKKMMCAGHVIPK-KKDIKRFEDEVKNFLEN------DKTGSLVGIHCTHGVNRTGYMVCRYLIDCC-GYEPE
             ...|. ..| ..| |  .   .| .|   .|. .| |||..|.|.      ...|. | .||..||.|||.... ||.  . |. .|
ehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdle

KAIEAFNQARGH-PLERENYLEDL
.|.. . . |..   . ..... |
eavkllreqRpgkavqtpsqyrfl
0046845 (Phosphotyrosine protein) phosphatases II 10-172 4.2e-13 44.8 In-house 58-259 (284) alignment 
Range on Protein: 10-172
Range on HMM: 58-259/284.0
DYSTCNWTP-------IEGQRIIIFKTPLSN-----------------------------KYNTSAPEDNGIEENERFTPTDLIEQLaqreMKLGLVLDF
||   .. .       .  ...|....||.|                             |.    |....  . ..|| | | |.     ..   |  .
dYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseev....kddytvrtl

TFTTRYYDPREFTAEGIIYKKMMcAGHVIPKKKDIKRFEDEVKNFLENDKTGSLVGIHCTHGVNRTGYMVCRYLIDCC--------GYEPEKAIEAFNQA
. |   |.  ..|   . |..     .| |  .|. .| ..|...||| ..|. . .|| .||.|||.... .|. ..        |. ...|.  . . 
eltnlgytgesrtvthfhytswp.dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreq

RGHPLER
| .  . 
Rpgmvqt
0040439 (Phosphotyrosine protein) phosphatases II 15-180 1.4e-21 72.7 In-house 45-239 (249) alignment 
Range on Protein: 15-180
Range on HMM: 45-239/249.0
NWTPI--EGQRIIIFKTPLSNkyntsapedngieenerfTPTDLIEQLAQRemKLGLVLDFTFTTRY---------------------------------
.. .    ..|.|....||..                  |  | ...| .   . . ....| ....                                 
syidgyyikrrfiatqgPlpe..................tvedfwrmlwel..gitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddy

----------YDPREFTAEGIIYKKMMcAGHVIPKKKDIKRFEDEVKNFLENDKTGSLVGIHCTHGVNRTGYMVCRYLI-----DCCGYEPEKAIEAFNQ
          ||. ..|  .| | ..    .| |  .|. .| ..|...||....|. | .||..||.|||.... ||.       .|. .| |.. ...
tvrtleltnlydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrs

ARGHPLERENYLEDLK
.|..  . ..... | 
qRpgavqnpeqyrfly
0045450 (Phosphotyrosine protein) phosphatases II 18-180 8.1e-18 60.6 In-house 103-297 (307) alignment 
Range on Protein: 18-180
Range on HMM: 103-297/307.0
PIEGQRIIIFKTPLSNkyntsapedngieenerfTPTDLIEQLAQRemKLGLVLDFTFTT--------RYYdPRE-------------------------
.. ....|....||..                  |. | ...| .   . ..... | ..        .|. | |                         
ydlkrkfIatqgPlpe..................tvedFwrmlweq..gvtvivmltelvelgrekcaqyw.Pdegeeltygnftvtllseehldgytvr

--------FTAEGIIYKKMMC---AGHVIP-KKKDIKRFEDEVKNFLENDKTGSLVGIHCTHGVNRTGYMVCRYLIDCCG--------YEPEKAIEAFNQ
        .| |... . . .    .| .|   ... .| .||...||... |. | .||..||.|||.... ||. ...        . ...|.. . .
tlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllre

ARGHPLERENYLEDLK
 |..  . ..... | 
qRpgavqnpeqyrfly
0040438 (Phosphotyrosine protein) phosphatases II 19-177 4.8e-17 57.6 In-house 81-266 (317) alignment 
Range on Protein: 19-177
Range on HMM: 81-266/317.0
IE--GQRIIIFKTPLSNkyntsapedngieenerfTPTDLIEQLAQRemKLGLVLDFTFTTRYYD----------------------PREFTAEGIIYKK
.   ....|....||.|                  |  | .. . .   ...... .| .. . .                        |.. .||.. .
gpnlkrkfIatqgPlpn..................tvedFwrmvweq..gvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrt

MMC-------------------AGHVIP-KKKDIKRFEDEVKNFLEndKTGSLVGIHCTHGVNRTGYMVCRYLI-----DCCGYEPEKAIEAFNQARGHP
...                     | .|   ... .| ..|...||  . |. | .||..||.|||.... ||.       .|. .|.|.. ....|.. 
levedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpga

LERENYLE
 . .....
vqtpeqyr
0042113 (Phosphotyrosine protein) phosphatases II 20-180 2.8e-17 58.4 In-house 50-236 (245) alignment 
Range on Protein: 20-180
Range on HMM: 50-236/245.0
EGQRIIIFKTPLSNkyntsapedngieenerfTPTDLIEQLAQRemKLGLVLDFTFTTRYYD--------------------------------------
  ...|..  ||..                  |. | ...| .   ..  ....| .. .                                        
itpkfiatqgPlpe..................tvedfwrmlwel..gittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlev

---PREFTAEGIIYKKMMCAGHVIPK-KKDIKRFEDEVKNFLENdKTGSLVGIHCTHGVNRTGYMVCRYLI-----DCCGYEPEKAIEAFNQARGHPLER
   .  .. |.| |  . . .| .|   ... .| ..|...|.. . .  | .||..||.|||.... ||.       .|. .|.|.. ... |..  . 
tnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqt

ENYLEDLK
..... | 
psqyrfly
0041856 (Phosphotyrosine protein) phosphatases II 21-176 4.9e-22 73.8 In-house 33-160 (182) alignment 
Range on Protein: 21-176
Range on HMM: 33-160/182.0
GQRIIIFKTPLSNkyntsapedngieenerfTPTDLIEQLAQRemKLGLVLDFTftTRYYDPREFTAEGIIYKKMMCAGHVIPKKKDIKRFEDEVKNfle
..|.|....|| .                  |. | ...| ..  . ..... |   ..|.| ... .|| |... . .| .|   .. .| .||..   
atrfiatqgplls..................tvadflrmlkel..gittivnlt..eelywpellerlgiqylylpwpDhgvpdldelldfieevle...

ndkTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAIEAFNQARGHPLERENYL
    |  | .||..||.|||..|. ||. ..|. .|.|.. ....| .  ...|..
...eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqy
0043336 (Phosphotyrosine protein) phosphatases II 21-177 9.3e-16 53.6 In-house 87-267 (278) alignment 
Range on Protein: 21-177
Range on HMM: 87-267/278.0
GQRIIIFKTPLSNkyntsA---------------------PEDNGIEENERFTPtD--------LIEQLAQREMKLGLVLDFTFTTRYYDPReFTAEGII
....|....||..                           ....| .   .. | .         .. | . ...   | ... | .....  .|  .. 
prkfiatqgPlpe.....tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyh

YKKMMcAGHVIPKKKDIKRFEDEVKNFLEndKTGSLVGIHCTHGVNRTGYMVCRYLI-----DCCGYEPEKAIEAFNQARGHPLERENYLE
|....  ..| .  ... .|  .|...||  . .. | .||..||.|||.... ||.     . .|. .|.|.. ... |.. .. .....
ylgwp.dhgvpeslsllldflkavreale..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyr
0039614 (Phosphotyrosine protein) phosphatases II 21-176 5.1e-15 51.2 In-house 100-278 (297) alignment 
Range on Protein: 21-176
Range on HMM: 100-278/297.0
GQRIIIFKTPLSNkyntsapedngieenerfTPTDLIEQLAQRemKLGLVLDFTFTTRY--------------------YDPREFTAEGII---------
....|....||..                  |. | .. . .   .   ..  | .. .                    .  .... .|..         
trkfIatqgPlpe..................tvedFwrmvweq..gvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnn

----------YKKMMcAGHVIPKKKDIKRFEDEVKNFLENDKTGSLVGIHCTHGVNRTGYMVCRYLI-----DCCGYEPEKAIEAFNQARGHPLERENYL
          | ..   ..| |  ... .| ..|...|.... |  | .||..||.|||.... ||.       .|. ...|.. ....|..  . ....
gesrtvthfqytgwp.dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqy
PTEN_1 40-178 6.1e-20 66.9 In-house 44-187 (196) alignment 
Range on Protein: 40-178
Range on HMM: 44-187/196.0
PEDNGIEENERFTPTDLIEQLAQR-EMKLGLVLDFTFTTRYYDPREFTAEGIIYKKMMCAGHVIPKKKDIKRFEDEVKNFLENDKTGSLVGIHCTHGVNR
 ... ....... . || .. ..   . . | ...   .| ||..|| ..|..|....   |  |    . .. ..... | .|. |  | .||..|..|
ideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgR

TGYMVCRYLIDCCGYEPEKAIEAFNQARGHPL----ERENYLED
.| .|. ||. . .. ...|.| ....| .      ..| .|| 
sGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlley
subfamily_PTEN_pd Subfamily PTEN 46-167 8.4e-13 43.7 In-house 40-157 (184) alignment 
Range on Protein: 46-167
Range on HMM: 40-157/184.0
EENERFTPTDLIEQLAQREMKLGLVLDFTfTTRYYDPREFTAEGIIYkkmMCAGHVIPKKKDIKRFEDEVKNFLENDKTgSLVGIHCTHGVNRTGYMVCR
|.. | . .|... | ..  .   ..... . |.|| ..|. . ..|    .  |  |. . .... ......||.||.  .| .||  |  ||| ... 
ealyRnsledvvkflekkhkdhykiynlr.serkydskkfdgrvavy...pfdDhnppplelleeivediekwleedkk.nvvvvHCkaGkGRtGvliva

YLIDCCGYEPE-KAIEAFNQARG
||. .. .| . .|.| |..|| 
yllkslllekaeealelfaeaRt
0043147 (Phosphotyrosine protein) phosphatases II 50-177 1e-19 66.4 In-house 30-151 (172) alignment 
Range on Protein: 50-177
Range on HMM: 30-151/172.0
RFTPTDLIEQLAQREMKLglVLDFTftTRYYDPREFTAEGIIYKKMMCAGHVIPKKKDIKRFEDEVKNFLeNDKTGSLVGIHCTHGVNRTGYMVCRYLID
|.|  | ...| ..  ..  ... |  ...|||  .. .|| |  . .  |  |  . . .| . ....| . . |  | .||..||.|||..|. ||. 
rntladfwrmlkelgith..ivnlt..ellydpellerlgiqylylpwpDhgvpllellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml

cCGYEPEKAIEAFNQARGHPLERENYLE
 .|. .|.|.. . ..|..  . .... 
.lglsleeavalvrekRpgavqnpsqyr
subfamily_CDC14_pd Subfamily CDC14 51-156 2.5e-08 28.1 In-house 199-294 (328) alignment 
Range on Protein: 51-156
Range on HMM: 199-294/328.0
FTPTDLIEQLAQREMKLGLVLDftftTRYYDPREFTAEGIIYKKMMCAGHVIPKKKDIKRFEDEVKNFlendkTGSlVGIHCTHGVNRTGYMVCRYLIDC
 .|  |.|  ......  . |.     . || ..||..|. .| .. .   .|... .|.| . ...      .|. . .||  |. ||| ..  ||.  
haPeklleyfrknnvttvvrLn....kklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGa.iavhCkaGLGrtGtLiacylmkh

CGYEPE
 ..  .
yrftaa
0051082 (Phosphotyrosine protein) phosphatases II 55-168 4.5e-16 54.3 In-house 24-134 (151) alignment 
Range on Protein: 55-168
Range on HMM: 24-134/151.0
DLIEQLaqREMKLGLVLDFTFTT-RYYDPREFTAEGIIYKKMMCAGHVIPKK----KDIKRFEDEVKNflendKTGSLVGIHCTHGVNRTGYMVCRYLID
| .|.|  .|...  ..... .. |.|.|. ....|| .. . . ..  |.     . ...| ... .     | .  | .||..|..||| .|. ||. 
dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylml

cCGYEPEKAIEAFNQARGH
 .|. .|.|.| . . |..
.lgvsleealeeyrlkrpg
0045098 (Phosphotyrosine protein) phosphatases II 56-169 4.9e-12 41.3 In-house 122-254 (278) alignment 
Range on Protein: 56-169
Range on HMM: 122-254/278.0
LIEQLAQREMKLGLVLDFTFTTRYYDPREFTAEGIIYKKM-MCAGHVIPKKK---DIKRFEDEVKNFLE-----------NDKTGSLVGIHCTHGVNRTG
 .. |   ...   . ... |  .. . ...  |. . ..     | .|       . .. ......|.            .  |  | .|| .||.|||
tvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtG

YMVCRYLIDCC---GYEPEKAIEAFNQARGH-P
 .|. ||. ..   |. ...|.. . . |..  
tlvaaylmlelleggvdlleavkelrsqRpgla
0048179 (Phosphotyrosine protein) phosphatases II 59-180 1.4e-19 65.7 In-house 22-138 (144) alignment 
Range on Protein: 59-180
Range on HMM: 22-138/144.0
QLAQREMKLGLVLDFTFTtryYDPREFTAEGIIYKKMMCAGHVIPKK-KDIKRFEDEVKNFLEndkTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEK
    .......|...| .   |.| ... ||| | .. . .| .|   ... .| . ....||    |  | .||..||.|||..|. ||. ..|. .|.
lellkklgittvinltee...yepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmkklglslee

AIEAFNQARGHPLERENYLEDLK
|.. . ..| .  . ...|. |.
alalvrsrrpgavpnpgqlrfLl
0049772 (Phosphotyrosine protein) phosphatases II 61-181 6.7e-21 70.8 In-house 167-268 (314) alignment 
Range on Protein: 61-181
Range on HMM: 167-268/314.0
AqremklglvldftftTRYYDPREFTAEGIIYKKMMCAGHVIPKKKDIKRFEDEVKNFlendKTGSLVGIHCTHGVNRTG-YMVCRYLIDCCGYEPEKAI
                ...|||  |. .|| |. . . ..  |  .|...| . ....    ..|. | .||..|..||| ..|. ||. ..|. .|.|.
k...............eelydpelferlgikylripvpDgsaplledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleeal

EAFNQARGhPLERENYLEDLKK
| . ..|     .....| |. 
edvrlkRp.inpnpgfieqleq
0048076 (Phosphotyrosine protein) phosphatases II 61-182 5.1e-19 63.8 In-house 24-138 (145) alignment 
Range on Protein: 61-182
Range on HMM: 24-138/145.0
AQREMKLGLVLDFtfttrYYDPREFTAEGIIYKKMMCAGHVIPKK-KDIKRFEDEVKNFLENDktgSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAI
  .......||..      .... ....|| |  . . .| .|   ... .| . ....|...     | .||..||.|||..|. ||. ..|. .|.|.
llkdlgittvlnl.....tselellerlgiqylylpwpDhgvpdllellleflefieealkeg...gpvlVHCsaGvgRtgtlvaaylmlllgvsleeal

EAFNQARGHPLERENYLEDLKKR
| . ..| .  .....|. |.. 
elvrsqrpgavpnpgqlrflyef
subfamily_DSP10_pd Subfamily DSP10 62-158 7.2e-07 23.2 In-house 35-125 (159) alignment 
Range on Protein: 62-158
Range on HMM: 35-125/159.0
QREMKLGLVLDFTFTTryydPREFTAEGIIYKKMMCAGHvipKKKDIKRFEDEVKNFLEN-DKTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKA
 .....  ||. | ..    | ||. |.. ||..        .|...|.  .|  .|.|.  |.|| | .||  |. |   .|  ||.   .   ..|
ldrlnitavlnvttsv....PnefeeealkYkripvsDt...skqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslnda
0044763 (Phosphotyrosine protein) phosphatases II 63-181 2.4e-20 68.3 In-house 45-165 (178) alignment 
Range on Protein: 63-181
Range on HMM: 45-165/178.0
REMKLGLVLDFTFTTRYY----DPREFTAEGIIYKKMMCAGHVIPK-KKDIKRFEDEVKNFLEndKTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEK
.|.........| .....    ||  .. .|| |... . .|  |   . . .| . ....|.  . |. | .||..||.|.|..|. ||. ..|. .|.
kelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkklglslee

AIEAFNQARGhPLERENYLEDLKK
||| . ..|    .....|. |..
aielvrerRp.ivpnpgqlrqLye
0051429 (Phosphotyrosine protein) phosphatases II 63-174 4.7e-10 35.1 In-house 42-212 (272) alignment 
Range on Protein: 63-174
Range on HMM: 42-212/272.0
REMKLGLVLDFTFTTR-YYDPREFTAEGIIYKKMMCAGHVIPKK----------------------------------------------------KDIK
.|...  ..|.. ..   ... .. ..|| |  . . ... |                                                      . ..
kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeall

RFEDEVKNflendktGSLVGIHCTHGVNRTGYMVCRYLIDcCGYE--------------PEKAIEAFNQARGHPLEREN
.. ... .       |  | .||..|..||| .|. .|.   | .              .|.|.|   ..| .  . | 
ellellld.......ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqtee
0049260 (Phosphotyrosine protein) phosphatases II 65-180 2.2e-19 65.1 In-house 30-143 (152) alignment 
Range on Protein: 65-180
Range on HMM: 30-143/152.0
MKLGLVLDFTFTTRYYDPREFTAEGIIYKKMMCAGHVIPKKKDIKRFEDEVKNFLeNDKTGSLVGIHCTHGVNRTGYMVCRYLIDcCGYEPEKAIEAFNQ
 .||     . |.............| |. . .  |  |.  .. .|  .. ..| . . |  | .||..||.||| .|. ||.  .|...|.|.. . .
kelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvre

ARGHPLERENYLEDLK
.| .  . ...|. |.
kRpgavpnpgqlrfly
0046846 (Phosphotyrosine protein) phosphatases II 66-177 1.2e-16 56.4 In-house 47-163 (176) alignment 
Range on Protein: 66-177
Range on HMM: 47-163/176.0
KLGLVLDFTFTT------RYYDPREFTAEGIIYKKMMCAGHVIPKKKDIKRFEDEVKNFLENDktgSLVGIHCTHGVNRTGYMVCRYLIDC-CGYEPEKA
. ..|...|  .       .... |....|| |. .    | .|  ... .. ......|...     | .|| .|..||| .|. ||. . .|. .|.|
gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeg...gpvlVHCsaGigRtgtlvaayllelekglsveea

IEAFNQARG-HPLERENYLE
.. . . |  . .. .....
lalvreqRplgavqtpeQyr
subfamily_Auxilin_pd Subfamily Auxilin 73-167 1.1e-06 21.4 In-house 54-145 (166) alignment 
Range on Protein: 73-167
Range on HMM: 54-145/166.0
FTFTTRYYDPREFTAEGIIYKkmmCAGHVIPKKKDIKRFEDEVKNFLENDKTGSLVgIHCTHGVNRTGYMVCRYLIDCCGY-EPEKAIEAFNQARG
. .. | |.. ....  . ..   .. . .|. . . .   .. ..|..|.   .| .||. |.  .. .|. .|. |  . |||.|.. |.  | 
ynlsqrtyrtaklssrvveag...wparraPnLeslvevcrnlyswlkkdpknvvv.vhckDGraasavlvsallvfcrllsepesavrlfsvkrl
0048567 (Phosphotyrosine protein) phosphatases II 74-168 2.6e-12 41.4 In-house 22-120 (157) alignment 
Range on Protein: 74-168
Range on HMM: 22-120/157.0
TFTTRYYDPREF-TAEGIIYKKMMCAGHvIPKKKDIKRFEDEVKNFLE-NDKTGSLVGIHCTHGV---NRTGYMVCRYLIDCCGYEPEKAIEAFNQARGH
  ....|..  | . .|..|  .       ..   . ||   ...||.  ...|  . .||..|     ||..... ||| ..|. ||.||. . ..| .
rlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpg
subfamily_VSP_pd Subfamily VSP 76-166 1.1e-12 42.3 In-house 83-170 (212) alignment 
Range on Protein: 76-166
Range on HMM: 83-170/212.0
TTRYYDPREFTAEgiiYKKMMCAGHVIPKKKDIKRFEDEVKNFLENDKTgSLVGIHCTHGVNRTGYMVCRYLIDCCGYEP-EKAIEAFNQAR
. | ||.. |  .    |...   | .|| ...  |  |||..||.|.   .. |||  | .||| .|| .|.    .|  ..... | . |
seraydekyfnnr...vkriliddhnvpkleellvftkevkewlekdlk.nvlaihckGGkgrtGtivcalllaseifetakesldyfgerr
subfamily_DSP23_pd Subfamily DSP23 76-168 6e-08 27.5 In-house 39-127 (148) alignment 
Range on Protein: 76-168
Range on HMM: 39-127/148.0
TTRYYdPREFTAEGIIYKKMMCAGHVIPKKKDIKRFedeVKNFLENDKTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAIEAFNQARGH
|..   |.  .. .. ....    .  |  .....|   |.   | .. .  |..||  |  ||| |.  ||.   .    .||    . |  
teegr.phveatpnltlvrlriddyhppaleqvvef...vrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpg
subfamily_PRL_pd Subfamily PRL 78-183 2.2e-08 28.3 In-house 44-149 (151) alignment 
Range on Protein: 78-183
Range on HMM: 44-149/151.0
RYYDPREFTAEGIIYKKMMCAGHVIPKKKDIKRFEDEVKNFLENdKTGSLVGIHCTHGVNRTGYMVCRYLIDcCGYEPEKAIEAFNQARGHPLERE--NY
  || ... .|||  . .  .    | .. .... . .|.  .. ...| |..||  |. |.  .|.  ||. .| ..|.|.|   . |   ....  ..
ptydteklekegievldlafddGavPpeevveeWlellkekfke.epkstvavhcvaGlGraPvlvalalie.aGmkyedavefirekrrgainskqlkf

LEDLKKRL
||. |.. 
lekykakk
subfamily_PTPDC1_pd Subfamily PTPDC1 80-177 2.6e-08 28.5 In-house 73-166 (182) alignment 
Range on Protein: 80-177
Range on HMM: 73-166/182.0
YDPREFTAEGIIYKKMMCAGHVIPKkkdIKRFEDEVKNFLENDKTGsLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAIEAFNQARGHPLERENYLE
||. .....||.. ..  . .  .    ..|  | ||      . |  |..||  |  ||| ... ||.    ...||||.   . | . ..  . .|
YdlealmeqgiyvynfgwkDygvas...leriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqve
subfamily_PTPMT1_pd Subfamily PTPMT1 81-174 1.3e-06 23.0 In-house 65-156 (171) alignment 
Range on Protein: 81-174
Range on HMM: 65-156/171.0
DPREFTAEGIIYKKMMCAGHVipKKKDIKRFEDEVKNFLENDKTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAIEAFNQARGHPLEREN
  .|.. .|. . ..    .   .. |... |. |.   .  ..|. | .||  |  |.. .|  ||.     .||.|..| .. | . . ...
steewkklgveqlqlatvDft..eapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakk
0051299 (Phosphotyrosine protein) phosphatases II 90-170 1.7e-08 29.7 In-house 187-269 (288) alignment 
Range on Protein: 90-170
Range on HMM: 187-269/288.0
IIYKKMMcAGHVIPKKKDIKRFEDEVKNFLEndKTGSLVGIHCTHGVNRTGYMVCRYLI-----DCCGYEPEKAIEAFNQARGHPL
. |..     .| .  ... .|  .|...|.  ..|. | .|| .||.||| ... .|.        | ....|.. . . | .  
fhytnwp.dhgvpdspellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmv
PTPc_DSPc_SM00012 97-151 3.3e-09 32.3 In-house 10-65 (105) alignment 
Range on Protein: 97-151
Range on HMM: 10-65/105.0
CAGHVIPK-KKDIKRFEDEVKNFLENDKTGSLVGIHCTHGVNRTGYMVCRYLIDCC
.  | .|.  ..| .. ..||.. .. .... | .|| .||.|||..|. ... . 
wpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqq
0047943 (Phosphotyrosine protein) phosphatases II 98-171 1.6e-10 36.4 In-house 178-256 (273) alignment 
Range on Protein: 98-171
Range on HMM: 178-256/273.0
AGHVIPKKKDIKRFEDEVKNFLENDKTGSLVGIHCTHGVNRTGYMVCRYLI-----DCCGYEPEKAIEAFNQARGHPLE
  .| |  ... .| ..|...||... .. | .|| .||.||| ... .|.        |  ...|.  . . | .  .
dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvq
DSPc Dual specificity phosphatase, catalytic domain 99-179 2.7e-14 48.1 Pfam-A 49-127 (133) alignment 
Range on Protein: 99-179
Range on HMM: 49-127/133.0
GhviPKKKDIKRFEDEVKNFLEN-DKTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAIEAFNQARGHPLERENYLEDL
     ....| .. .|...|.|. .. |  | .||..|..|.......||..  ... ..|.|.... |..  .....|  |
d...etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqL
DSPc Dual specificity phosphatase, catalytic domain 99-179 2.7e-14 48.1 In-house 49-127 (133) alignment 
Range on Protein: 99-179
Range on HMM: 49-127/133.0
GhviPKKKDIKRFEDEVKNFLEN-DKTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAIEAFNQARGHPLERENYLEDL
     ....| .. .|...|.|. .. |  | .||..|..|.......||..  ... ..|.|.... |..  .....|  |
d...etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqL
0050432 (Phosphotyrosine protein) phosphatases II 100-171 1.2e-08 30.2 In-house 211-283 (308) alignment 
Range on Protein: 100-171
Range on HMM: 211-283/308.0
HVIPKKKDIKRFEDEVKNFLendkTGSLVGIHCTHGVNRTGYMVCRYLI-----DCCGYEPEKAIEAFNQARGHPLE
.| |. ... .| ..|...|     |. . .|| .||.||| ... .|.       .|  ...|.  . . | .  .
gvPpspeilldflelvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvq
0036941 (Phosphotyrosine protein) phosphatases II 101-171 1.8e-09 32.8 In-house 183-261 (297) alignment 
Range on Protein: 101-171
Range on HMM: 183-261/297.0
VIPKKKDIKRFEDEVKNFLENDKTGSLVGIHCTHGVNRTGYMVCRYLI--------DCCGYEPEKAIEAFNQARGHPLE
| .  ... .| ..|...|..   |. | .|| .||.|.| ... .|.          .|. . .|.  . . | .  .
vpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavq
PTPc_motif_SM00404 103-181 6.7e-14 47.0 In-house 57-136 (140) alignment 
Range on Protein: 103-181
Range on HMM: 57-136/140.0
PKKKDIKRFEDEVKNFLEN-DKTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAIEAFNQARGHPLERENYLEDLKK
 .|... .. |.|..|.||  |.|  | .||..||.|...... ||..  ... ..|.|.... | .  ...|... | .
nekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLie
subfamily_DSP12_pd Subfamily DSP12 105-181 6.2e-07 23.9 In-house 61-138 (155) alignment 
Range on Protein: 105-181
Range on HMM: 61-138/155.0
KKDIKRFEDEVKNFLENDK-TGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPEKAIEAFNQARGHPLERENYLEDLKK
..|| .. ||. .|.|.   ..  | .||. || |   .|  ||.   . . |||... .... .    |..|| || 
eediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLkl