Gene DSP12 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP12
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP007_AA protein Get Run
NvecP007_AA_1-146 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0051082 (Phosphotyrosine protein) phosphatases II 2-139 5.1e-21 70.3 In-house 9-150 (151) alignment 
Range on Protein: 2-139
Range on HMM: 9-150/151.0
RLVKPGLYAGTREDAMNYCQLKEAAINRVLTIDSQS----LPDLQDDRQKKSLFVYCLDEPNADLLSHLDECIRFIEDGIKH-EEPVLVHCLAGVSRSIA
. | .|||..    | .. .|||  |. .... |      .|..  . . . | ...|| |. .|  ..|....|.|  ... . |||||| ||..|. .
syvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGt

VILAYIMKsDQVSLDDAVNKMSEIYSSEISPNQGFLDQLKIYE
....|.|.  .|||..|.. . ..    . |||.|| ||. ..
lvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfall
subfamily_STYX_pd Subfamily STYX 2-141 2.8e-15 49.8 In-house 13-156 (166) alignment 
Range on Protein: 2-141
Range on HMM: 13-156/166.0
RLVKPGLYAGTREDAMN--YCQLKEAAINRVLTIDSQSLPDLQDDRQ---KKSLFVYCLDEPNADLLSHLDECIRFIEDGIKHEEPVLVHCLAGVSRSIA
. . |||. |    ||.    .||.  |  .. |  .   .|         . | .   |..  ... .| .   ||.| ...   ||||  ||.||| |
qeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaa

VILAYIMKSDQVSLDDAVNKMSEIySSEISPNQGFLDQLKIYEEM
...||||..  .   .|   . |     |.||.|| .||| || .
lviayimetyglkyreafayvqer.rfcinpnegfvsqlkeyeai
subfamily_DSP12_pd Subfamily DSP12 3-153 2.3e-57 187.8 In-house 4-154 (155) alignment 
Range on Protein: 3-153
Range on HMM: 4-154/155.0
LVKPGLYAGTREDAMNYCQLKEAAINRVLTIDSQSLPDLQDDRQKKS-LFVYCLDEPNADLLSHLDECIRFIEDGIKHEEPVLVHCLAGVSRSIAVILAY
 ..|||| |. |.......|||..|..||......||. .....|.| .|...||||..|.||||||...|||.....|. ||||| ||||||.....||
rilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

IMKSDQVSLDDAVNKMSEIySSEISPNQGFLDQLKIYEEMGCKVNTSSALFK
.||....||..|.....|. ..||.||.|||.|||..|.|||||.||.  .|
lmkkeklslekAlklvkek.kpeiepNegFleQLklfekmgckvdtsnkayk
subfamily_DSP15_pd Subfamily DSP15 3-142 9e-30 97.8 In-house 4-139 (151) alignment 
Range on Protein: 3-142
Range on HMM: 4-139/151.0
LVKPGLYAGTREDAMNYCQLKEAAINRVLTIDSQSLPDLQDdrqKKSLFVYCLDEPNADLLSHLDECIRFIEDGIKHEEPVLVHCLAGVSRSIAVILAYI
 | |||| | ..|. .  .|||  |  .|..  .. . |.|   .. ...   | |.|.| ....|...|| .   .|| ||||||||||||. .. ||.
kvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd...ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MKSDQVSLDDAVNKMSEIYSSeISPNQGFLDQLKIYEEMG
|   ...  ||.. . .  |.   || ||  ||| ||.. 
mtvtelnwrdalevikaaRsv.anPnfGfkrqlkeyektk
PTPc_motif_SM00404 3-140 6.5e-29 95.6 In-house 4-139 (140) alignment 
Range on Protein: 3-140
Range on HMM: 4-139/140.0
LVKPGLYAGTREDAMNYCQLKEAAINRVLTIDS-QSLPdlQDDRQKKSLFVYCLDEPNADLLSHLDECIRFIEDGIKHEEPVLVHCLAGVSRSIAVILAY
 . |.|| |. ..|.| ..||.  |  |. . . .||.  . . ... | .   |. ...|. .||....|||. .| .. ||||| |||||| ..|.||
rilphlylgskskaqnpallkklgithvinvteevslt..kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

IMKSDQVSLDDAVNKMSEIYsSEISPNQGFLDQLKIYEE
.|...|.||..|.. ..|   . |||| .|. ||  ||.
lmryrqlslaeayefvkerR.piispnlnfvrqLieyek
0044763 (Phosphotyrosine protein) phosphatases II 3-144 1.1e-28 95.5 In-house 25-172 (178) alignment 
Range on Protein: 3-144
Range on HMM: 25-172/178.0
LVKPGLYAGTREDAMNYCQLKEAAINRVLTIDSQS-------LPDLQDDRQKKSLFVYCLDEPNADLLSHLDECIRFIEDGI-KHEEPVLVHCLAGVSRS
 . ||||.|.  .|... .|||  |. .... .         .|   ..   . |.. . | .. |||.|..|...|||. . ....|||||| |||.||
eilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRs

IAVILAYIMKSDQVSLDDAVNKMSEIYSseISPNQGFLDQLKIYEEMGCK
 ....||.||. ..||..|.. . |  .  |.||.|.| ||. .|.. .|
gtlvaaylmkklglsleeaielvrerRp..ivpnpgqlrqLyefelrllk
0048179 (Phosphotyrosine protein) phosphatases II 3-140 2.2e-27 90.9 In-house 6-142 (144) alignment 
Range on Protein: 3-140
Range on HMM: 6-142/144.0
LVKPGLYAGTREDAMNYCQLKEAAINRVLTIDSQSLPDLQDDRQKKSLFVYCLDEPNADLLSHLDECIRFIEDGIKHEEPVLVHCLAGVSRSIAVILAYI
 . |||| |   .|... .||.  |. |... ..  |.   .   . |.. . | .  |||..|.|...|||. .....|||||| |||.|. ....||.
eilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaayl

MKSDQVSLDDAVNKMSEIYSsEISPNQGFLDQLKIYEE
||  ..||..|.. . ....  . ||.|.| .|. ||.
mkklglsleealalvrsrrp.gavpnpgqlrfLleyek
0048076 (Phosphotyrosine protein) phosphatases II 3-141 7.2e-27 89.2 In-house 6-141 (145) alignment 
Range on Protein: 3-141
Range on HMM: 6-141/145.0
LVKPGLYAGTREDAMNYCQLKEAAINRVLTIdsQSLPDLQDDRQKKSLFVYCLDEPNADLLSHLDECIRFIEDGIKHEEPVLVHCLAGVSRSIAVILAYI
 . |||| |   .|... .||.  | .||..   | ..|  .   . |.. . | .  |||..|.|...|||. .|...|||||| |||.|. ....||.
eilpglylgslptaldlellkdlgittvlnl..tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MKSDQVSLDDAVNKMSEIYSSeISPNQGFLDQLKIYEEM
|.. .|||..|.... . ..  . ||.|.| .|. .|..
mlllgvsleealelvrsqrpg.avpnpgqlrflyefele
0051429 (Phosphotyrosine protein) phosphatases II 3-139 8.8e-12 40.7 In-house 18-221 (272) alignment 
Range on Protein: 3-139
Range on HMM: 18-221/272.0
LVKPGLYAGTRE----DAMNYCQLKEAAINRVLTIDSQSLPDLQD-D---RQKKSLFVYCLDEPNADLLSHL----------------------------
 ||||..  .      .| .. .|||  |. .... | .  . .. |    . . |.. .||.   . | .                             
vvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsag

--------------------DECIRFIEDGIKhEEPVLVHCLAGVSRSIAVILAYIMKsDQVS--------------LDDAVNKMSEIYsSEISPNQGFL
                    .......|   . ..|||||| ||..|.  |......   .||              |..||... ...   . ......
earevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqr.pgavqteeqy

DQLKIYE
 .|  ..
lflyeal
subfamily_DSP19_pd Subfamily DSP19 4-140 6.8e-32 104.9 In-house 15-148 (152) alignment 
Range on Protein: 4-140
Range on HMM: 15-148/152.0
VKPGLYAGTREDAMNYCQLKEAAINRVLTIDSQsLPDL-QDDRqkKSLFVYCLDEPNADLLSHLDECIRFIEDGIKHEEPVLVHCLAGVSRSIAVILAYI
|.| || |  . |... .|||  |  .| .  . .|..  .|   . | . .||.|..||||.|.|.. |||.. ...  ||||| |||||| .|..||.
veprlylgsqdvaadkeilkekkitHilnvatg.vpnvfpkdf..tylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviayl

MKSDQVSLDDAVNKMSEIYSsEISPNQGFLDQLKIYEE
||. ..|| .|.... |.    |.||.||. ||| ||.
mkkeelsleealelvrearp.cikPneGFikqLkeyea
subfamily_DSP1_pd Subfamily DSP1 4-141 1.6e-27 90.6 In-house 21-155 (163) alignment 
Range on Protein: 4-141
Range on HMM: 21-155/163.0
VKPGLYAGTREDAMNYCQLKEAAINRVLTIDSQsLPDLQDD-RQKKSLFVycLDEPNADLLSHLDECIRFIEDGIKHEEPVLVHCLAGVSRSIAVILAYI
... || |....| |  .||.  |  .| . .. |..  .|  . |.| .   |.|.||. ....| | ||.. .|..  ||.|| ||.||| ...|||.
ildfLylGsetvasnleiLkslgitailnvske.ldnvfedlfeYkklkl..eDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclayl

MKSDQVSLDDAVNKMSEiYSSEISPNQGFLDQLKIYEEM
||...|||..| . . .   | |||| ||  ||. ||. 
mktkrvsleeafdfvkq.rRsiisPnagFvlqLlnyekk
subfamily_DSP14_pd Subfamily DSP14 4-141 2.1e-25 83.5 In-house 10-143 (157) alignment 
Range on Protein: 4-141
Range on HMM: 10-143/157.0
VKPGLYAGtREDAMNYCQLKEAAINRVLTIDSqSLPDlQDDRQKKSLFVYCLDEPNADLLSHLDECIRFIEDGIKHEEPVLVHCLAGVSRSIAVILAYIM
..| |. .    |..  .||.. |. .. .    ||. .. .. . . |   |.|.|.| .|.|| .  ||.  |..  .|||| |||||| .. |||.|
itpsLfls.gvaalskellkkkkitliinvtv.elpn.tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylm

KSDQVSLDDAVNKMSEIySSEISPNQGFLDQLKIYEEM
|  ..|| .| . . ..  . |.||.||  ||  ||. 
kyeklsLreayklvksa.RpiirPNvGFwkqlidyEkk
subfamily_DSP8_pd Subfamily DSP8 4-140 5.7e-25 81.7 In-house 18-152 (159) alignment 
Range on Protein: 4-140
Range on HMM: 18-152/159.0
VKPGLYAGTREDAMNYCQLKEAAINRVLTIdSQSLPDLQDDRQKKSLFVYCLDEPNADLLSHLDECIRFIEDGIKHEEPVLVHCLAGVSRSIAVILAYIM
. . || |...|...   |..  |. || . |.| |.|.  ...| | |   |. . .||  .|. . ||.   ...  ||||.||| ||| .|..||||
ilknlylGsqkdvlseellsklgisyvlna.snscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayim

KSDQVSLDDAVNKMSEIYsSEISPNQGFLDQLKIYEE
|  ..|||.| . . |     ||||  ||.||  ||.
ktlemsldeayrfvkekr.ptispnlnflgqLleyek
subfamily_LRR-DSP_pd Subfamily LRR-DSP 4-141 1.2e-24 80.8 In-house 123-257 (263) alignment 
Range on Protein: 4-141
Range on HMM: 123-257/263.0
VKPGLYAGTREDAMNYCQLKEAAINRV-LTIDSqSLPdLQDDRQKKSLFVYCLDEPNADLLSHLDECIRFIEDGIKhEEPVLVHCLAGVSRSIAVILAYI
. ..|. |... |.|   ||.  .  . |..     | |  .  |        | ..||.  |..|   |||.| | .  ||||| |||||| .....|.
iidklflGgldsannksilkdlgvthillavad.feP.lfPklfkylsiddiedvdeadisqhfeetnafieeGrk.kGGvlvhcraGvsrsstlvisyl

MKSDQVSLDDAVNKMsEIYSSEISPNQGFLDQLKIYEEM
|| ... . .|.. .     ..| ||.||.|||| ||. 
mkkqrlkfkealdlv.ikkrpriqPnpGfkdqlkkyekk
0041856 (Phosphotyrosine protein) phosphatases II 4-148 1.4e-24 82.1 In-house 22-178 (182) alignment 
Range on Protein: 4-148
Range on HMM: 22-178/182.0
VKPGLYAGTRED--------------AMNYCQLKEAAINRVLTID-SQSLPDLQDDRQKKSLFVYCLDEPNADllshLDECIRFIEDGIKHEEPVLVHCL
. ..||.| . .              |... .|||  |. ....   .  |.|  .   . |.. . | .  |    |||...|||. .....|||||| 
InanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvlVHCs

AGVSRSIAVILAYIMKSDQVSLDDAVNKMSEIYS-SEISPNQGFLDQLKIYEEMGCKVNTS
|||.|. ....||.||. .|||..||. . .  . . |.|||.|. ||...|.. .|....
aGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkktrp
subfamily_DSP3_pd Subfamily DSP3 4-140 7.9e-23 74.9 In-house 14-155 (162) alignment 
Range on Protein: 4-140
Range on HMM: 14-155/162.0
VKPGLYAGTREDAMNYCQLKEAAINRVLTIDSQSL------PDLQDDRQKKSLFVYCLDEPNADLLSHLDECIRFIEDGIKH-EEPVLVHCLAGVSRSIA
| |.|| | .. |..  .||.. |  ||     ..      ..  .| . | | .   | |..||  . ..  .||.. ... |  ||||| .||||| .
vypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsat

VILAYIMKSDQVSLDDAVNKMSEiySSEISPNQGFLDQLKIYEE
..|||.| . ...| .|.... .    || ||.||| ||. ..|
lvlayLmirrkmtlveairtvrk..kReilPneGFlkqLaelde
0046846 (Phosphotyrosine protein) phosphatases II 4-141 1.6e-20 69.0 In-house 15-171 (176) alignment 
Range on Protein: 4-141
Range on HMM: 15-171/176.0
VKPGLYAGTRE----------DAMNYCQLKEAAINRVLTIDSQ------SLPDLQDDRQKKSLFV---YCLDEPNADLlSHLDECIRFIEDGIKHEEPVL
. ..|..| |            | .  .|||. |. |... .       ..|.. .. .| .. .      |    || ..|.|...||.. .|. .|||
inanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeggpvl

VHCLAGVSRSIAVILAYIMKS-DQVSLDDAVNKMSEIYSSEISPNQGFLDQLKIYEEM
||| ||..|. ....||....  ..|...|. .. |. .  . ...... .|. .| .
VHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
PTEN_1 4-141 5.1e-16 54.1 In-house 44-190 (196) alignment 
Range on Protein: 4-141
Range on HMM: 44-190/196.0
VKPGLYAGTREDA-MNYCQLKEAAINRVLTIDSQS----LPDLQDDRQKKSLF---VYCLDEPNADLLSHLDECIRFIEDGIK--HEEPVLVHCLAGVSR
. .||| | ..|. ..  .|||  |  |.. .. .     ..  ....|. .    .   | .  .| ...|.| .|||  ..  ... ||||| ||..|
ideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgR

SIAVILAYIMKSDQVSLDDAVNKMSEIySSEISPNQGFLDQLKIYEEM
|  |. || |.. . . |.|.  . |   . ..||.... .|. |...
sGtvvaayLmykgkltadeAlelvrek.Rppgapnspsqerlleyfae
subfamily_DSP10_pd Subfamily DSP10 5-141 1.6e-26 87.1 In-house 18-152 (159) alignment 
Range on Protein: 5-141
Range on HMM: 18-152/159.0
KPGLYAGTREDAMNYCQLKEAAINRVLTIDSQsLPDLQDDRQKKSLFVYCLDEPNADLLSHLDECIRFIEDGIKHEEPVLVHCLAGVSRSIAVILAYIMK
 | |. |  .|| .   |.. .|. || . .. .|   .. . |   .   |  . .|  . .| . |||.  |... ||||| ||.||| .|..||.||
lpfLflGsekdaadldaldrlnitavlnvtts.vPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmk

SDQVSLDDAVNKMSEIySSEISPNQGFLDQLKIYEEM
  ..|| || . ..|   . |||| .|. ||. .|. 
hlnlslndaykfvkek.rpiisPnLnfmGqLlefeke
subfamily_DSP6_pd Subfamily DSP6 6-141 6e-32 104.3 In-house 19-153 (158) alignment 
Range on Protein: 6-141
Range on HMM: 19-153/158.0
PGLYAGTREDAMNYCQLKEAAINRVLTIDSQSLPDLQDDRQKKSLFVYCLDEPNADLLSHLDECIRFIEDGIKHEEPVLVHCLAGVSRSIAVILAYIMKS
| || |...|| |   ||.  |..|| . |.     ... . | | .   |. ...| ... | |.||... .... ||||||||.|||..|.|||.||.
pllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlaylmkk

DQVSLDDAVNKMSEiYSSEISPNQGFLDQLKIYEEM
 ..||.|| . . .   |.||||  |..||. .|..
lalslndaydlvkk.rksnisPnfnfmgqlldfers
0043147 (Phosphotyrosine protein) phosphatases II 6-141 1.3e-20 69.2 In-house 24-159 (172) alignment 
Range on Protein: 6-141
Range on HMM: 24-159/172.0
PGLYAGTREDAMNYCQLKEAAINRVLTIDSQ-SLPDLQDDRQKKSLFVYCLDEPNAdLLSHLDECIRFIED--GIKHEEPVLVHCLAGVSRSIAVILAYI
.... . . .|... .|||  |. .... .   .|.|  .   . |.... | .   ||..|.|...||..   .. ..|||||| |||.|. ....||.
atqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaayl

MKsDQVSLDDAVNKMSEIYsSEISPNQGFLDQLKIYEEM
|.  ..||..||. . |   . ...|.... .|. .|..
ml.lglsleeavalvrekR.pgavqnpsqyrflyyfekl
subfamily_MKPLT_pd Subfamily MKPLT 7-141 9.5e-18 58.3 In-house 28-159 (164) alignment 
Range on Protein: 7-141
Range on HMM: 28-159/164.0
GLYAGTREDAMNYCQLKEAAINRVLTIDSQSLPDLQDDrqKKSLFVYCLDEPNADLLSHLDECIRFIEDGIKHEEPVLVHCLAGVSRSIAVILAYIMKSD
 || |  ..| |   ||.  |. .. .  . .         . | |   ||..  | |.|.    |. | |.    |||||  |.||| .| .|...|| 
tlylGnakhatnekvlkdlkithivnvsqekkdafpks..veYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

QVSLDDAVNKMSEIYsSEISPNQGFLDQLKIYEEM
.  |..| . . |   | ..||.||| ||  .||.
gwtlkeayeylkerr.sivapnrGflkqlakfeel
subfamily_MKPLV_pd Subfamily MKPLV 7-141 9.5e-18 58.3 In-house 28-159 (164) alignment 
Range on Protein: 7-141
Range on HMM: 28-159/164.0
GLYAGTREDAMNYCQLKEAAINRVLTIDSQSLPDLQDDrqKKSLFVYCLDEPNADLLSHLDECIRFIEDGIKHEEPVLVHCLAGVSRSIAVILAYIMKSD
 || |  ..| |   ||.  |. .. .  . .         . | |   ||..  | |.|.    |. | |.    |||||  |.||| .| .|...|| 
tlylGnakhatnekvlkdlkithivnvsqekkdafpks..veYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

QVSLDDAVNKMSEIYsSEISPNQGFLDQLKIYEEM
.  |..| . . |   | ..||.||| ||  .||.
gwtlkeayeylkerr.sivapnrGflkqlakfeel
DSPc Dual specificity phosphatase, catalytic domain 8-140 1.3e-26 88.0 Pfam-A 1-132 (133) alignment 
Range on Protein: 8-140
Range on HMM: 1-132/133.0
LYAGTREDAMnYCQLKEAAINRVLTIDSQSL-PDLQDDRQKKSLFVYCLDEPNADLLSHLDECIRFIEDGIKHEEPVLVHCLAGVSRSIAVILAYIMKSD
|| |. ..|.  ..|..  |. |. . ..   . .. . ... | .   || .... ..|.|...|||. .. .. ||||| ||.||| ..|.||.||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

QVSLDDAVNKMSEIYsSEISPNQGFLDQLKIYEE
..||..|.. ..|   | |||| ||| ||  ||.
nlslneAyefvkerr.skispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 8-140 1.3e-26 88.0 In-house 1-132 (133) alignment 
Range on Protein: 8-140
Range on HMM: 1-132/133.0
LYAGTREDAMnYCQLKEAAINRVLTIDSQSL-PDLQDDRQKKSLFVYCLDEPNADLLSHLDECIRFIEDGIKHEEPVLVHCLAGVSRSIAVILAYIMKSD
|| |. ..|.  ..|..  |. |. . ..   . .. . ... | .   || .... ..|.|...|||. .. .. ||||| ||.||| ..|.||.||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

QVSLDDAVNKMSEIYsSEISPNQGFLDQLKIYEE
..||..|.. ..|   | |||| ||| ||  ||.
nlslneAyefvkerr.skispnagflrqLleyer
subfamily_Slingshot_pd Subfamily Slingshot 8-141 2.8e-24 79.4 In-house 26-156 (169) alignment 
Range on Protein: 8-141
Range on HMM: 26-156/169.0
LYAGTREDAMNYCQLKEAAINRVLTIDSqSLPDLQDDRQKkSLFVYCLDEPNADLLSHLDECIRFIEDGIKHEEPVLVHCLAGVSRSIAVILAYIMKSDQ
.| |.  .| |. .|||  .. .| .    . .  ... .  | .   ||...|||.. .|  .|||   |..  |||||  ||||| ....|| ||. .
vylGsewnasnleelkengveyilnvtk.eidnffpekfe.ylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyg

VSLDDAVNKMSEIySSEISPNQGFLDQLKIYEEM
.||..|.. . |   | | ||.||| ||..|| .
lsleealeyvker.rsvikPnkgflkqleeyeGi
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 8-140 3.8e-24 78.8 In-house 10-150 (154) alignment 
Range on Protein: 8-140
Range on HMM: 10-150/154.0
LYAGTREDAMNYCQLKEAAINRVLTI---DSQSLPDLQDDRQKKSLFVYC----LDEPNADLLSHLDECIRFIEDGI--KHEEPVLVHCLAGVSRSIAVI
|| .. . |.|  .|..  |. .| .    .  ..| . | .   .. |.     |..| |.. .|| .  ||.| |   ... ||||. .||||| |..
lyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaall

LAYIMKSDQVSLDDAVNKMSEIySSEISPNQGFLDQLKIYEE
..|.|.. ..||  |.  . .     |.||||||.||.|.| 
isylmdklkislslalellkds.ryiikPnqGflkqleifek
subfamily_STYXL1_pd Subfamily STYXL1 8-141 7.7e-23 74.4 In-house 19-152 (157) alignment 
Range on Protein: 8-141
Range on HMM: 19-152/157.0
LYAGTREDAMNYCQLKEAAINRVLTIDSQ--SLPDLQDDrQKKSLFVYCLDEPNADLLSHLDECIRFIEDGIKHEEPVLVHCLAGVSRSIAVILAYIMKS
|| |. ..|.|    |.  .  .. . ..   | . ..|   | | .   ||..||||..|.| ..|||.  |..| |||    |.|||.|||.||.| |
lylGnykqaqnpaikkdlkvkahvnvsmdadkliagvad.vakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmys

DQVSLDDAVNKMSEIySSEISPNQGFLDQLKIYEEM
 ...| .| ... .   . . ||..|..||. .|..
kkitlkkaykylkkC.kenvkPnrafveqlseWekq
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 8-140 2.3e-19 63.4 In-house 15-145 (148) alignment 
Range on Protein: 8-140
Range on HMM: 15-145/148.0
LYAGTREDAMNYCQLKEAAINRVLTIDSqSLPDLQDDRQKKSLFVYCLDEPNADLLSHLDECIRFIEDGIKHEEPVLVHCLAGVSRSIAVILAYIMKSDQ
|. | .. |... .||.  . |. .    . .   |.|  . | |   |.|. || .  .. | |..   .. . ||||.  ||||| |. |..... ..
LFlGskksaadlealkalgvtrivnatk.erdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkr

VSLDDAVNKMSEIYSSeISPNQGFLDQLKIYEE
||| .|.. . .     . ||.||| ||  .|.
vslkealalvkskrry.vdpnlgfLkqLaeleq
0049260 (Phosphotyrosine protein) phosphatases II 8-140 8e-18 60.0 In-house 15-147 (152) alignment 
Range on Protein: 8-140
Range on HMM: 15-147/152.0
LYAGTREDAMNYCQLKEAAINRVLTIDSQSLP-DLQDDRQKKSLFVYCLDEPNADLLSHLDECIRFIED-GIKHEEPVLVHCLAGVSRSIAVILAYIMKs
.. |    | .. .|||  |. .... . .    |. ..  . |.... | .  ||  .|.....|||   .. ..|||||| |||.|. ....||.|. 
qgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.

DQVSLDDAVNKMSEIYsSEISPNQGFLDQLKIYEE
 .|||..||. . |   . . ||.|.| .|. .|.
lgvsleeavalvrekR.pgavpnpgqlrflyefek
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 8-134 8.3e-17 54.6 In-house 6-133 (145) alignment 
Range on Protein: 8-134
Range on HMM: 6-133/145.0
LYAGTREDAMNYCQLKEAAINRVLTIDSQSLPDLQDDRQK--KSLFVYCLDEPNADLLSHLDECIRFIEDGIKHEEPVLVHCLAGVSRSIAVILAYIMKS
|| |.   | .   |.|  | |.. . . ||   |. . .  . |..   |    ||  |.||   ||. | .    |.|||.||||||..| .|..|| 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

DQVSLDDAVNKMSEiYSSEISPNQGFLDQ
 ...| .|  ..         ||  || .
cnmtlseaarqvrs.nrllaypnvtflkn
0036282 (Phosphotyrosine protein) phosphatases II 20-140 5.2e-16 54.3 In-house 30-167 (174) alignment 
Range on Protein: 20-140
Range on HMM: 30-167/174.0
CQLKEAAINRVLTIDSQSLP-------------DLQDDRQKKSLFVYCLDEPNADLLShLDECIRFIEDGIKH--EEPVLVHCLAGVSRSIAVILAYIMK
 .|||  |. |..  .   .             .   .   . |.. . |    ||   |.|...|.|. ...  . |||||| |||.|. ....||.|.
emlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylml

SDQV-SLDDAVNKMSEIY--SSEISPNQGFLDQLKIYEE
  .  ||.||.. . |.    . . ...... .|  .| 
rglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
0040439 (Phosphotyrosine protein) phosphatases II 42-140 2.5e-17 58.8 In-house 135-243 (249) alignment 
Range on Protein: 42-140
Range on HMM: 135-243/249.0
QDDRQKKSLFVYCLDEPNADLLSHLDECIRFIEDGIK------HEEPVLVHCLAGVSRSIAVILAYIM-----KSDQVSLDDAVNKMSEIYSSeISPNQG
.|.   . | ....| |  .. ........|||   |       ..|||||| |||.|. ..|.||.|     |  .|.|..||... .  .  . .|..
ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpg.avqnpe

FLDQLKIYEE
.. .|  .. 
qyrflyeall
0036941 (Phosphotyrosine protein) phosphatases II 42-120 3.9e-14 48.1 In-house 163-255 (297) alignment 
Range on Protein: 42-120
Range on HMM: 163-255/297.0
QDDRQKKSLFVYCLDEPNADLLSHLDECIRFIEDGIK------HEEPVLVHCLAGVSRSIAVILAYIM--------KSDQVSLDDAVNKMSEI
... ...    .... |  .. .. .....|||   |       ..|||||| |||.|| ..|.|..|        |  .|.. .||.|. | 
gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReq
0047943 (Phosphotyrosine protein) phosphatases II 43-119 1.6e-12 42.9 In-house 162-249 (273) alignment 
Range on Protein: 43-119
Range on HMM: 162-249/273.0
DDRQKKSLFVYCLDEPNADLLSHLDECIRFIEDGIK------HEEPVLVHCLAGVSRSIAVILAYIM-----KSDQVSLDDAVNKMSE
..  ..   ..... |. .  ..|.....|||.  |      ...||.||| |||.|. ..|.....     |  .|....||... .
tgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrs
0050432 (Phosphotyrosine protein) phosphatases II 43-119 5e-12 41.2 In-house 193-276 (308) alignment 
Range on Protein: 43-119
Range on HMM: 193-276/308.0
DDRQKKSLFVYCLDEPNADLLSHLDECIRFIEDGIKH--EEPVLVHCLAGVSRSIAVILAYIM-----KSDQVSLDDAVNKMSE
|.  ..    .... |. .  ........|.|   |.  ..|..||| |||.|. ..|.....     |   |.. .||.|. |
dgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklRe
0051299 (Phosphotyrosine protein) phosphatases II 43-119 6.8e-12 40.9 In-house 178-263 (288) alignment 
Range on Protein: 43-119
Range on HMM: 178-263/288.0
DDRQKKSLFVYCLDEPNADLLSHLDECIRFIEDGIKH----EEPVLVHCLAGVSRSIAVILAYIM-----KSDQVSLDDAVNKMSE
|.  ..    .... |. .  ........|... .|.    . ||.||| |||.|. ..|.....     |   |.. .||... |
dgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlre
0049772 (Phosphotyrosine protein) phosphatases II 45-141 6.9e-26 87.1 In-house 179-272 (314) alignment 
Range on Protein: 45-141
Range on HMM: 179-272/314.0
RQKKSLFVYCLDePNADLLSHLDECIRFIEDGiKHEEPVLVHCLAGVSRSI-AVILAYIMKSDQVSLDDAVNKMSEIYSseISPNQGFLDQLKIYEEM
.  | | . . | ..|.||...||...|||.  . ..|||||| ||..|.  .|..||.||  .|||..|.. . ....  |.||.||. ||. ||..
lgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp..inpnpgfieqleqyefi
0040438 (Phosphotyrosine protein) phosphatases II 46-139 1.1e-14 49.8 In-house 170-272 (317) alignment 
Range on Protein: 46-139
Range on HMM: 170-272/317.0
QKKSLFVYCLDE-PNADLLSHLDECIRFIEDGIKH----EEPVLVHCLAGVSRSIAVILAYIM-----KSDQVSLDDAVNKMSEIYsSEISPNQGFLDQL
..  . ...    |  .. ...|....|.|   ..    ..|||||| |||.|. ..|.||.|     |  .|....||... |   . . .. ... .|
esrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqR.pgavqtpeqyrfl

KIYE
  ..
ydal
0046845 (Phosphotyrosine protein) phosphatases II 47-119 1.2e-10 36.7 In-house 165-251 (284) alignment 
Range on Protein: 47-119
Range on HMM: 165-251/284.0
KKSLFVYCLDEPNADLLSHLDECIRFIEDGIKH------EEPVLVHCLAGVSRSIAVILAYIMKSD--------QVSLDDAVNKMSE
..    .... |. .  ....  ..|...  ..      ..|..||| |||.|. ..|.......          |.. .||... |
rtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlre
0045450 (Phosphotyrosine protein) phosphatases II 49-139 7.3e-17 57.5 In-house 194-300 (307) alignment 
Range on Protein: 49-139
Range on HMM: 194-300/307.0
SLFV---YCLDEPNADLLSHLDECIRFIEDGIK------HEEPVLVHCLAGVSRSIAVILAYIMKSDQ--------VSLDDAVNKMSEIYsSEISPNQGF
|..|   .... |. .. ....|...|||   |       ..|||||| |||.|. ..|.||.|..          |.|..||... |   . . .|...
srtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR.pgavqnpeq

LDQLKIYE
. .|  ..
yrflyeal
0045098 (Phosphotyrosine protein) phosphatases II 50-141 5.3e-19 64.1 In-house 162-270 (278) alignment 
Range on Protein: 50-141
Range on HMM: 162-270/278.0
LFVYCLDEPNADLLSHLDECIRFIEDGIK--------------HEEPVLVHCLAGVSRSIAVILAYIMKSD---QVSLDDAVNKMSEIYSSEISPNQGFL
|..   . |. ..|....|...||.. .|              ...|||||| |||.|. ....||.|..    .|.|..||... .    .. .|....
lpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqy

DQLKIYEEM
 .|  .. .
rflyeflle
0042113 (Phosphotyrosine protein) phosphatases II 50-138 6.5e-16 53.9 In-house 144-238 (245) alignment 
Range on Protein: 50-138
Range on HMM: 144-238/245.0
LFVYCLDEPNADLLSHLDECIRFIEDGIK--HEEPVLVHCLAGVSRSIAVILAYIM-----KSDQVSLDDAVNKMSEIYsSEISPNQGFLDQLKIY
... . | . .|||..|.....|... ..   ..|||||| |||.|. ..|.||.|     |   |||..|| .. .   . . ...... .|  .
hylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqR.pgavqtpsqyrflyea
0043336 (Phosphotyrosine protein) phosphatases II 50-121 4.1e-12 41.6 In-house 176-256 (278) alignment 
Range on Protein: 50-121
Range on HMM: 176-256/278.0
LFVYCLDEPNADLLSHLDECIRFIEDGIK----HEEPVLVHCLAGVSRSIAVILAYIM-----KSDQVSLDDAVNKMSEIY
. ...|. |  .. ..|.  ..|... ..     ..|||||| |||.|. ..|..|..     |   |.|..||... |  
thyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR
0039614 (Phosphotyrosine protein) phosphatases II 52-140 5.3e-15 51.1 In-house 191-286 (297) alignment 
Range on Protein: 52-140
Range on HMM: 191-286/297.0
VYCLDEPNADLLSHLDECIRFIEDGIK---HEEPVLVHCLAGVSRSIAVILAYIM-----KSDQVSLDDAVNKMSEIYsSEISPNQGFLDQLKIYEE
.   |    ..|..|.| ...... ..    ..|||||| |||.|. ..|.||.|     |  .|....||... |   . . .. ... .|  .. 
tgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR.pgavqtpsqyrflydall
subfamily_PTPMT1_pd Subfamily PTPMT1 54-140 1.2e-12 42.7 In-house 81-166 (171) alignment 
Range on Protein: 54-140
Range on HMM: 81-166/171.0
CLDEPNADLLSHLDECIRFIEDGIKHEEPVLVHCLAGVSRSIAVILAYIMKSDQVSLDDAVNKMSEIYSsEISPNQGFLDQLKIYEE
  |  .|  | .| . ..|||. ... . | ||| || .|| ... .|.||....|...|.. . .. .  |  ..  ...|. |||
tvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRk.iirlakkqwkalqeyee
0037934 (Phosphotyrosine protein) phosphatases II 55-139 1e-17 60.0 In-house 144-238 (243) alignment 
Range on Protein: 55-139
Range on HMM: 144-238/243.0
LD----EPNADLLSHLDECIRFIED-----GIKHEEPVLVHCLAGVSRSIAVILAYIMKSD-QVSLDDAVNKMSEIYSSEISPNQGFLDQLKIYE
 |    .  .|||..|||.. |||.      .....|||||| |||.|. ..|.||.|..  .|.|..||... |  .  . ...... .|  ..
pdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal
0038934 (Phosphotyrosine protein) phosphatases II 55-140 2.1e-13 45.8 In-house 88-174 (194) alignment 
Range on Protein: 55-140
Range on HMM: 88-174/194.0
LDE----PNADLLSHLDECIRFIEDgiKHEEPVLVHCLAGVSRSIAVILAYIMKSDQVSLDDAVNKMSEIYSSEIsPNQGFLDQLKIYEE
 |     ... ||. || . .|...  . .. |.||| ||..|.  .. ||.... . |...|.. ..|.  . | |||..|..|  . .
pddgtvPsleillrfldlvdeflne..dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgai.pnqdyleallkryk
PTPc_DSPc_SM00012 61-107 1.4e-07 27.0 In-house 21-66 (105) alignment 
Range on Protein: 61-107
Range on HMM: 21-66/105.0
DLLSHLDECIRFIE---DgikhEEPVLVHCLAGVSRSIAVILAYIMKSDQ
..|..|... .. .   .    ..||.||| |||.|.  .....|. .. 
silellravkknknkses....skpvvVhCsaGvgRtgtfvaldillqql
subfamily_DSP23_pd Subfamily DSP23 61-118 1.5e-06 22.9 In-house 65-122 (148) alignment 
Range on Protein: 61-118
Range on HMM: 65-122/148.0
DLLSHLDECIRFIEDGIKHEEPVLVHCLAGVSRSIAVILAYIMKSDQVSLDDAVNKMS
  |  ..| .| .|.  ...| | |||| |  |. ...  |..|  ...  .|. .. 
paleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevr
subfamily_RNGTT_pd Subfamily RNGTT 63-127 3.9e-06 20.7 In-house 97-160 (189) alignment 
Range on Protein: 63-127
Range on HMM: 97-160/189.0
LSHLDE-CIRFIEDgiKHEEPVLVHCLAGVSRSIAVILAYIMKSDQVSLDDAVNKMSEIYSSEISP
 ... . . .|...  . || . |||  |  |.  .| .|...  ..|...||.  ..     |  
vkefiklveeffkk..npeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiyk
subfamily_MSG5_pd Subfamily MSG5 64-141 2e-14 47.1 In-house 83-159 (165) alignment 
Range on Protein: 64-141
Range on HMM: 83-159/165.0
SHLDECIRFIEDGIKHEEPVLVHCLAGVSRSIAVILAYIMKSDQVSLDDAVNKMSEIySSEISPNQGFLDQLKIYEEM
  | .  | |     ... .||||  |.||| ..|.|||||  ..|| || .|.    . .|||. |.. ||  .| .
kdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksv.addispsiglifqlmeweva
subfamily_CDKN3_pd Subfamily CDKN3 65-123 9.3e-06 19.3 In-house 114-176 (202) alignment 
Range on Protein: 65-123
Range on HMM: 114-176/202.0
HLDECIRFIED---GIKHEEPVLVHCLAGVSRSIAVILAY-IMKSDQVSLDDAVNKMSEIYSS
.  .|....|.    .|     ||||  |. ||  ||    .. .|... .||..|. ..  |
diasclkileelrinlkayrktlvhcygglgrsslviaclllylddtiepkdaidklrdlkgs