Gene DSP6 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP6
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP012_AA protein Get Run
NvecP012_AA_206-352 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 29-153 1.3e-15 49.9 Pfam-A 1-112 (113) alignment 
Range on Protein: 29-153
Range on HMM: 1-112/113.0
SPNWLSEQMrSGNYVLLLDCRPFAEFVRSHIQGAINLTIPSLmlrrmkkGNNFSFTSLISSEEGKEQFNKNLHMATAVVLYDsNTKDIASIGINSVMAVL
|...| |..  .. |.|||.|...|. ..||.||.|.  .||        .. . ..    .|  |.  | |   . ||.|. .... .. .  .. | .
sakelkell.ekekvvllDvRspeeyakghIpgAvnvpldsl.......yprrdlffkdklaeeleesgkkldkdktvvvyc.rsgnrsggaaalllali

IKKLADEcasgTLRLLEGGFSKFEE
.|.|  .    . ..|.|||... .
lkelgyk....nvyvLdGGfeawka
subfamily_DSP10_pd Subfamily DSP10 199-351 2.1e-60 197.2 In-house 4-155 (159) alignment 
Range on Protein: 199-351
Range on HMM: 4-155/159.0
PENRNVSNCELAEILPRLYLGSEKDASNIELLRKHKISYVLNVTHDRPNTFAHiEGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAG
|.. .. . .....|| |.|||||||.....|....|..||||| . ||.|.. |..||| .||.|.   || . | ||..||.| |.|.|.||||| ||
pteadietapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaG

ISRSVTITIAYLMSSQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFERSLNL
||||.|..|||||  ..||||.||.||| ... .|||.|||||||.||..|| 
isrsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnk
0037934 (Phosphotyrosine protein) phosphatases II 200-348 7.4e-28 93.1 In-house 30-240 (243) alignment 
Range on Protein: 200-348
Range on HMM: 30-240/243.0
ENRNVSNCELAEILPRLYLGSE--------KDASNIELLRKHKISYVLNVTHDR------------------------------------------PN-T
|. .  |  | ...|||....         ..||....| ...|......|..                                           .. .
egsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldld

FAHIEGFKYKNLPVED----NLMANLTELFPEAFAFIDE-----GRQKSSNVLVHCLAGISRSVTITIAYLMSSQ-HLSLNEAYDFVKARKSN-VSPNFN
  . ....|  ||. |    . ...| ... |. .||.|      . ... ||||| ||..|. |. .|||| .. ...| ||.......... . ....
dltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtps

FMGQLLDFERS
.. .| .... 
qyrflyealle
subfamily_DSP6_pd Subfamily DSP6 201-351 5.5e-77 250.7 In-house 6-156 (158) alignment 
Range on Protein: 201-351
Range on HMM: 6-156/158.0
NRNVSNCELAEILPRLYLGSEKDASNIELLRKHKISYVLNVTHDRPNTFAHIEGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAGIS
... ... ..||||.|||||.|||||.|.|.|.||.||||||...||.|.. . .||...|.||.|..||...||||..||||.|.|.|.||||||||||
lkkaeaefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGis

RSVTITIAYLMSSQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFERSLNL
||||.|.||||....||||.|||.||.||||.|||||||||||||||||.|
rsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrl
0049772 (Phosphotyrosine protein) phosphatases II 202-349 1.4e-32 109.1 In-house 155-273 (314) alignment 
Range on Protein: 202-349
Range on HMM: 155-273/314.0
RnvsncelaeilprlylgSEKDASNIELLRkhkisyvlnvthDRP--NTFAHIEGFKYKNLPVEDnLMANLTELFPEAFAFIDEGrQKSSNVLVHCLAGI
                  .| .|...|||.            ..   . .   .|.||...||.|   |.|.| |.|...||.|  .| ..||||| ||.
g.................neptaadlellk............eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGk

SRSVT-ITIAYLMSSQHLSLNEAYDFVKARKSnVSPNFNFMGQLLDFERSL
.|. | ...||||. ...||.||...|... . ..||..|. ||...|  |
gRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefil
0036282 (Phosphotyrosine protein) phosphatases II 203-349 2e-29 97.9 In-house 6-169 (174) alignment 
Range on Protein: 203-349
Range on HMM: 6-169/174.0
NVSNCELAEILPRLYLGSEKDAsNIELLRKHKISYVLNVTHDRPN-------------TFAHIEGFKYKNLPVEDNLMANLTElFPEAFAFIDEGRQK--
|.|.. | .|.|||..|.   | ..|.|....|..|..... ...             .. . .|..|. ||..|. . .|.. . |.. |..| ...  
naspldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedp

SSNVLVHCLAGISRSVTITIAYLMSSQHL-SLNEAYDFVKARK---SNVSPNFNFMGQLLDFERSL
.  ||||| ||..|. |. .||||  ..| || .|.|.|....   ... ...... .| .||. |
ggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0042113 (Phosphotyrosine protein) phosphatases II 203-347 2.7e-25 84.6 In-house 41-240 (245) alignment 
Range on Protein: 203-347
Range on HMM: 41-240/245.0
NVSNCELAEILPRLYLGSEKDASNIE----LLRKHKISYVLNVTHDRP--------------------------------------------NTFAHIEG
| |   . .| |......   ....|    .|....|......| . .                                             .. . |.
nasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrev

FKYKNLPVEDNLMANLTELFPEAFAFIDEGRQ--KSSNVLVHCLAGISRSVTITIAYLM-----SSQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFER
. |  ||..|. ...|.||. ... |... ..  ..  ||||| ||..|. |. .||||     . . .|| ||..... ..... ...... .| ....
ihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
subfamily_DSP8_pd Subfamily DSP8 204-351 3.3e-45 147.5 In-house 10-156 (159) alignment 
Range on Protein: 204-351
Range on HMM: 10-156/159.0
VSNCELAEILPRLYLGSEKDASNIELLRKHKISYVLNVTHDRPNTfAHIEGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAGISRSV
| . .. .||. |||||.||. . |||.|  ||||||. .  |..   ..  |.  .||.|.   .| . |.... |||  ......||||.||||||| 
vadvgptrilknlylGsqkdvlseellsklgisyvlnasnscpkl.eelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsa

TITIAYLMSSQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFERSLNL
|. |||.|   ..||.||| ||| ..  .|||.||.||||..|..|.|
tvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelkl
subfamily_DSP3_pd Subfamily DSP3 204-350 1.9e-32 106.2 In-house 6-158 (162) alignment 
Range on Protein: 204-350
Range on HMM: 6-158/162.0
VSNCELAEILPRLYLGSEKDASNIELLRKHKISYVLNVTHDRP------NTFAHIEGFKYKNLPVEDNLMANLTELFPEAFAFIDEGR-QKSSNVLVHCL
.  .|. |. |.||.| |. |.. . |.|  | .||| .. |       . | .  ..||  |.|.|. ...| . | .|..||||   ||.. ||||| 
llskevdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcv

AGISRSVTITIAYLMSSQHLSLNEAYDFVKARKsNVSPNFNFMGQLLDFERSLN
.|.||| |. .|||| .....|.||   |.... .. ||  |. || .....|.
vGvsRsatlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeelk
0044763 (Phosphotyrosine protein) phosphatases II 205-350 6.6e-41 135.2 In-house 19-171 (178) alignment 
Range on Protein: 205-350
Range on HMM: 19-171/178.0
SNCELAEILPRLYLGSEKDASNIELLRKHKISYVLNVTHDRPNTFAHI-------EGFKYKNLPVEDNLMANLTELFPEAFAFIDEGR-QKSSNVLVHCL
 .  . ||||.|||||  .|...|||....|....|.|.. .. | .        .|..|...|..|.   .|.| |.|...||.| . .| ..||||| 
dyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCs

AGISRSVTITIAYLMSSQHLSLNEAYDFVKARKSnVSPNFNFMGQLLDFERSLN
||..|| |. .|||| ...|||.||...|..|.. ..||.... ||..||. |.
aGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll
subfamily_DSP19_pd Subfamily DSP19 206-348 7.3e-41 134.0 In-house 9-149 (152) alignment 
Range on Protein: 206-348
Range on HMM: 9-149/152.0
NCELAEILPRLYLGSEKDASNIELLRKHKISYVLNVTHDRPNTFAhiEGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAGISRSVTI
. |..|. |||||||   |.. | |...|| ..|||. . ||.|.  . |.|..... |.  ..|.. ..||. ||.|.|.|   ||||| ||.|||...
dlevgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfp..kdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasv

TIAYLMSSQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFERS
 |||||....|||.||.. |.. . ...||  |. || ..| .
viaylmkkeelsleealelvrearpcikPneGFikqLkeyeae
PTEN_1 206-351 1e-31 105.3 In-house 42-193 (196) alignment 
Range on Protein: 206-351
Range on HMM: 42-193/196.0
NcelaEILPRLYLGSEKDA-SNIELLRKHKISYVLNVTHDRPN-------TFAHIEGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQKS--SNVLVHC
     || ..||.||.||. .. . | ...|  |.|.......       ...  .|..|...|.||    .| ||| ..  ||.  ....   .|||||
q....eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHC

LAGISRSVTITIAYLMSSQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFERSLNL
 ||..||.|. .||||... |. .|| ..|... ....||  .. .|| ....|. 
kaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaella
subfamily_STYX_pd Subfamily STYX 207-347 1.5e-26 86.4 In-house 10-155 (166) alignment 
Range on Protein: 207-347
Range on HMM: 10-155/166.0
CELAEILPRLYLGSEKDA--SNIELLRKHKISYVLNVTHDRPNTFAH---IEGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAGISR
 |. |||| |.||    |  | .| |.|| |.... .  .   .. .    . |.|  | | || . |.   .|.  .|||.  ||  .||||  |||||
remqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisr

SVTITIAYLMSSQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFER
| .. |||.| .  |   ||. .|. |.  ..||  |. || ..| 
saalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
subfamily_DSP14_pd Subfamily DSP14 208-350 5.3e-36 117.9 In-house 6-145 (157) alignment 
Range on Protein: 208-350
Range on HMM: 6-145/157.0
ELAEILPRLYLGsEKDASNIELLRKHKISYVLNVTHDRPNtfAHIEGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAGISRSVTITI
.|..| | |.|.    |.. |||.|.||. ..||| . ||   ....... ..|||||  |.|.. | |. . |.| ..|  ..|||| ||.||| ....
alsqitpsLfls.gvaalskellkkkkitliinvtvelpn..tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslcl

AYLMSSQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFERSLN
||||  ..|||.|||  ||.... ..||  |  || |.|. |.
aylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklk
0041856 (Phosphotyrosine protein) phosphatases II 208-349 4.7e-33 109.7 In-house 18-172 (182) alignment 
Range on Protein: 208-349
Range on HMM: 18-172/182.0
ELAEILPRLYLGSEKD--------------ASNIELLRKHKISYVLNVThdR-P--NTFAHIEGFKYKNLPVEDNLMANltelFPEAFAFIDEGRQKSSN
 | .|...||||| ..              |.....|....|....|.|    .   .. . .|..|..||..|.   .    ..|...||.| .... .
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggp

VLVHCLAGISRSVTITIAYLMSSQHLSLNEAYDFVKARKS--NVSPNFNFMGQLLDFERSL
||||| ||..|. |. .|||| ....|| ||...|. |..   ..||..|. ||. .|. |
vlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll
0045098 (Phosphotyrosine protein) phosphatases II 208-350 8.6e-28 92.9 In-house 21-272 (278) alignment 
Range on Protein: 208-350
Range on HMM: 21-272/278.0
ELAEILPRLYLGSEK-----------------------------------------DASNIELLRKHKISYVLNVTHD----------------------
   ||.| ||||. .                                          |.....|....|......|.                       
ipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygd

----------------------------RPNTFAHIEGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQ--------------KSSNVLVHCLAGISRS
                              .. .... ..|.. |  .    ...  | |.. ||.| ..              ..  ||||| ||..|.
ftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRt

VTITIAYLMSSQ---HLSLNEAYDFVKARKSN-VSPNFNFMGQLLDFERSLN
 |. .|||| ..   ...| ||..... .. . . .|.... .| .|.. | 
GtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_DSP12_pd Subfamily DSP12 209-348 2.4e-39 129.2 In-house 2-142 (155) alignment 
Range on Protein: 209-348
Range on HMM: 2-142/155.0
LAEILPRLYLGSEKDASNIELLRKHKISYVLNVTHDR-PNTFAHIEGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAGISRSVTITI
. .|||.||||. ... . |||.. ||. || |.. . |.  ...   ..|.... |.  ... . ..||..||.|....  .||||| ||.|||||| |
vsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtivi

AYLMSSQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFERS
|||| ...|||..|...||. |....|| .|. ||  ||..
AYlmkkeklslekAlklvkekkpeiepNegFleQLklfekm
subfamily_DSP15_pd Subfamily DSP15 209-347 9.5e-39 126.9 In-house 2-137 (151) alignment 
Range on Protein: 209-347
Range on HMM: 2-137/151.0
LAEILPRLYLGSEKDASNIELLRKHKISYVLNVTHdrpNTFAHIEGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAGISRSVTITIA
. ..|| ||||  .|... |||....|. .|.|     |.  ... ..|| ....|   |.|.. | |.  || . | |  |||||||||.|||||...|
iskvlpglylgnfrdskdeelLkeknithilsvhd...nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvva

YLMSSQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFER
|||.  .|. ..| ...||..|   ||| |  || ..|.
YlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyek
0046846 (Phosphotyrosine protein) phosphatases II 209-348 2.1e-29 97.9 In-house 12-171 (176) alignment 
Range on Protein: 209-348
Range on HMM: 12-171/176.0
LAEILPRLYLGSEK----------DASNIELLRKHKISYVLNVTHDR-------PNTFAHI--EGFKYKNLPVEDNLMANLtELFPEAFAFIDEGRQKSS
| .|...|.|||             |...|.|....|..|.|.| ..       || .  .  .|..|..||..|.   .| ||..|...||.| ...  
ldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkegg

NVLVHCLAGISRSVTITIAYLMSS-QHLSLNEAYDFVKARKS-NVSPNFNFMGQLLDFERS
.||||| |||.|. |. .|||. . ..||..||...|..... .. ...... .| .||. 
pvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
0051082 (Phosphotyrosine protein) phosphatases II 209-344 1.6e-24 81.6 In-house 8-148 (151) alignment 
Range on Protein: 209-344
Range on HMM: 8-148/151.0
LAEILPRLYLGSEKDASNIELLRKHKISYVLNVTHDR----PNTFAHIEGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQK-SSNVLVHCLAGISRSV
.  . ..||...   | ..|||....|....|.. .        . . .|......|..|.   .| ..|... .|... ..| . .||||| ||..|. 
fsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTG

TITIAYLMSsQHLSLNEAYDFVKARKS-NVSPNFNFMGQLLD
|. ..|||  ...||.||.......    | ||  |. ||..
tlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfa
0036941 (Phosphotyrosine protein) phosphatases II 209-348 8.6e-18 60.1 In-house 19-275 (297) alignment 
Range on Protein: 209-348
Range on HMM: 19-275/297.0
LAEILPRLYLGSEKDASNIELLR----------------------------------------------------------KHKISYVLNVTHDRPN---
  |.||.|.||| . |.. | |                                                           ..... ....| . ..   
feellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgre

-----------TFAHIEGFKYKNLPVED-------------------------------NLMANLTELFPEAFAFIDEGRQ------KSSNVLVHCLAGI
            .   ..|. ..| ||                                    .. | . . ..||.. |.      ... ||||| ||.
kcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGv

SRSVTITIAYLM--------SSQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFERS
.|| |. .|.||          . ... ||. ... .. .. ...... .| ...  
gRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyealle
PTPc_motif_SM00404 210-347 1e-44 146.8 In-house 3-139 (140) alignment 
Range on Protein: 210-347
Range on HMM: 3-139/140.0
AEILPRLYLGSEKDASNIELLRKHKISYVLNVTHDRPNTfAHIEGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAGISRSVTITIAY
 .|||.|||||...|.| .|| |..|..|.|||   ..|  . .||.....|..||  ..|.. .... .||.. ..|  .||||| ||.|||.|..|||
srilphlylgskskaqnpallkklgithvinvteevslt.kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMSSQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFER
||....|||.|||.||| |....|||.||. ||...|.
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek
0048179 (Phosphotyrosine protein) phosphatases II 210-348 9.1e-38 124.5 In-house 5-143 (144) alignment 
Range on Protein: 210-348
Range on HMM: 5-143/144.0
AEILPRLYLGSEKDASNIELLRKHKISYVLNVTHDRPNTFAHIEGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAGISRSVTITIAY
.||||.|||||  .|...|||.|..|..|.|.|......|   ||..| .||..|.   .|.||..|...||.| .... .||||| ||..|. |. .||
seilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay

LMSSQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFERS
||  ..|||.||...|..| ... ||.... .||..|. 
lmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
subfamily_Slingshot_pd Subfamily Slingshot 210-350 9.7e-38 123.2 In-house 20-158 (169) alignment 
Range on Protein: 210-350
Range on HMM: 20-158/169.0
AEILPRLYLGSEKDASNIELLRKHKISYVLNVTHDRPNTFAhiEGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAGISRSVTITIAY
..|   .||||| .|||.| |......|.||||..  | |.  | |.|.|. | |.  ..| . . |.. ||.. ..| |.|||||  |.||| .. |||
skifdhvylGsewnasnleelkengveyilnvtkeidnffp..ekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviay

LMSSQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFERSLN
 | . .|||.||...|| |.| . || .|. ||  .|  |.
amkeyglsleealeyvkerrsvikPnkgflkqleeyeGile
0048076 (Phosphotyrosine protein) phosphatases II 210-349 8.3e-37 121.4 In-house 5-142 (145) alignment 
Range on Protein: 210-349
Range on HMM: 5-142/145.0
AEILPRLYLGSEKDASNIELLRKHKISYVLNVTHDRPNTFahIEGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAGISRSVTITIAY
.||||.|||||  .|...|||....| .|||.|..... .   .|..| .||..|.   .|.||..|...||.| ...  .||||| ||..|. |. .||
seilpglylgslptaldlellkdlgittvlnltselelle..rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay

LMSSQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFERSL
|| ....|| ||...|... ... ||.... .|..||. |
lmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_DSP1_pd Subfamily DSP1 211-350 1.6e-48 158.9 In-house 20-157 (163) alignment 
Range on Protein: 211-350
Range on HMM: 20-157/163.0
EILPRLYLGSEKDASNIELLRKHKISYVLNVTHDRPNTFAHieGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAGISRSVTITIAYL
.||. ||||||..||| |.|....|. .|||... .|.| .   |.||.|..||. .|.....| |.  |||| ..|   ||.|| |||||| |. .|||
kildfLylGsetvasnleiLkslgitailnvskeldnvfed..lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclayl

MSSQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFERSLN
|.....||.||.|||| |.| .|||..|..|||..|..| 
mktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
0043147 (Phosphotyrosine protein) phosphatases II 211-349 5.8e-34 112.7 In-house 21-160 (172) alignment 
Range on Protein: 211-349
Range on HMM: 21-160/172.0
EILPRLYLGSEKDASNIELLRKHKISYVLNVThD--RPNTFAHIEGFKYKNLPVEDNLMAnLTELFPEAFAFIDE--GRQKSSNVLVHCLAGISRSVTIT
.... ...... .|.....|....|....|.| .   . .. . .|..|  ||..|.    |.||..|.. ||||   ....  ||||| ||..|..|. 
rfiatqgplrntladfwrmlkelgithivnlt.ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlv

IAYLMSsQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFERSL
.||||  ..||| ||...|.........|.... .|..||. |
aaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
subfamily_LRR-DSP_pd Subfamily LRR-DSP 211-349 5.9e-32 104.8 In-house 122-258 (263) alignment 
Range on Protein: 211-349
Range on HMM: 122-258/263.0
EILPRLYLGSEKDASNIELLRKHKISYV-LNVTHDRPnTFAhiEGFKYKNL-PVEDNLMANLTELFPEAFAFIDEGRQKsSNVLVHCLAGISRSVTITIA
||...|.||. . | |  .|..  .... | |.. .|  |   . |||  .  .||   |..   | |  |||.|||.|   ||||| ||.||| |..|.
eiidklflGgldsannksilkdlgvthillavadfeP.lfP..klfkylsiddiedvdeadisqhfeetnafieeGrkk.GGvlvhcraGvsrsstlvis

YLMSSQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFERSL
|||  |.| ..||.|.|. ..... ||  |. ||. .|. |
ylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl
0049260 (Phosphotyrosine protein) phosphatases II 211-349 7.4e-31 102.3 In-house 10-149 (152) alignment 
Range on Protein: 211-349
Range on HMM: 10-149/152.0
EILPRLYLGSEKDASNIELLRKHKISYVLNVTHDRPNTFA-HIEGFKYKNLPVEDNLMANLTELFPEAFAFIDE-GRQKSSNVLVHCLAGISRSVTITIA
|... ...|..  |.....|....|......| . ....  . ....|..||..|.   .|..|..... ||..  ..|. .||||| ||..|. |. .|
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaa

YLMSsQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFERSL
|||  ...|| ||...|....... ||.... .|..||. |
ylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
subfamily_STYXL1_pd Subfamily STYXL1 211-349 5.8e-29 94.3 In-house 13-153 (157) alignment 
Range on Protein: 211-349
Range on HMM: 13-153/157.0
EILP-RLYLGSEKDASNIELLRKHKISYVLNVTHDRPNTFAHIEG-FKYKNLPVEDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAGISRSVTITIA
|.|| .|||| .|.| | .. .  |.  ..||..|  . .| ...  |  ...|||.  |.| | . ||  ||.. ..... |||    |||||... ||
evlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviia

YLMSSQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFERSL
||| |....|..||...|  |.|| || .|. || ..|..|
ylmyskkitlkkaykylkkCkenvkPnrafveqlseWekql
0040439 (Phosphotyrosine protein) phosphatases II 211-348 6.2e-24 80.4 In-house 31-244 (249) alignment 
Range on Protein: 211-348
Range on HMM: 31-244/249.0
EILPRLYLGSEKDASNIEL------------------------LRKHKISYVLNVTHDRPNTF-------------------------------------
.||| |.|..  .|| |..                        |....|......|.. .. .                                     
silpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtle

----AHIEGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQ------KSSNVLVHCLAGISRSVTITIAYLM-----SSQHLSLNEAYDFVKARKSNVSP
     . | .... ... |    .. . |.....||.. |.      |.. ||||| ||..|. |. .||||       ....| ||..... ..... .
ltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavq

NFNFMGQLLDFERS
|.... .|..... 
npeqyrflyealle
0038934 (Phosphotyrosine protein) phosphatases II 211-349 6.1e-20 67.1 In-house 33-176 (194) alignment 
Range on Protein: 211-349
Range on HMM: 33-176/194.0
EILPRLYLGSEKDASNIELLRKHKISYVLNVTHDRP-NTFAHIE--GFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQK--SSNVLVHCLAGISRSVTI
. .. ||  | .|  .   |...|. .|...|.. .     ..|  |..| .||..|   .  .|.  . . ..||  ..  .  |.||| ||..|. |.
kyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtl

TIAYLMSSQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFERSL
 .|||. ....|..||..... .. .. || ... .|| . . |
vaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykel
0051429 (Phosphotyrosine protein) phosphatases II 212-352 2.1e-20 69.0 In-house 19-227 (272) alignment 
Range on Protein: 212-352
Range on HMM: 19-227/272.0
ILPR-LYLGSEK---DASNIELLRKHKISYVLNVTHDR----PNTFAHIEGFKYKNLPVEDNLMANLT--------------------------------
..|. ||...     .| ... |....|.........      ... ...|..| .||..|.     .                                
vkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsage

-------------------ELFPEAFAFIDEgrqkSSNVLVHCLAGISRSVTITIAYLMSsQHLS--------------LNEAYDFVKARKSNVSPNFNF
                   | . |..... .    . .||||| ||..|. |.  ..|.  . .|              | ||.. ..|.  .. ..  .
arevmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeq

MGQLLDFERSLNLP
. .|..... |  .
ylflyeallellrs
subfamily_MSG5_pd Subfamily MSG5 212-350 2.6e-19 62.9 In-house 30-161 (165) alignment 
Range on Protein: 212-350
Range on HMM: 30-161/165.0
ILPRLYLGSEKDASNIelLrkhKISYVLNVTHDRPNTFAHIEGFKYKNLPVEDNlmANLTELFPEAFAFIDEGRQKSSNVLVHCLAGISRSVTITIAYLM
. ..||| ||    ..  |    .  |.||... ..    .   ||  .  | .  ....  ...    |   . |   .||||  |.||| .. .||.|
lpeklylysepklkel..l...sfdlvinvakeindlellvpavkyyhiewehd..skivkdlsrltriihaatskrkkilvhcqcglsrsaslivayim

SSQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFERSLN
    |||..||| .|..  ..||.. .. ||...|  |.
kyynlslrdaydklksvaddispsiglifqlmewevals
subfamily_MKPLT_pd Subfamily MKPLT 215-347 9.1e-28 90.8 In-house 28-158 (164) alignment 
Range on Protein: 215-347
Range on HMM: 28-158/164.0
RLYLGSEKDASNIELLRKHKISYVLNVTHDRPNTFAhiEGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAGISRSVTITIAYLMSSQ
.||||  |.| | ..|.. || ...||. .. . |.  . ..| .. |||.   .|.. .  |  |. .  .    |||||  | ||| ..|.|.|..|.
tlylGnakhatnekvlkdlkithivnvsqekkdafp..ksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

HLSLNEAYDFVKARKSNVSPNFNFMGQLLDFER
   |.|||...| |.| |.||  |. ||  ||.
gwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 215-347 9.1e-28 90.8 In-house 28-158 (164) alignment 
Range on Protein: 215-347
Range on HMM: 28-158/164.0
RLYLGSEKDASNIELLRKHKISYVLNVTHDRPNTFAhiEGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAGISRSVTITIAYLMSSQ
.||||  |.| | ..|.. || ...||. .. . |.  . ..| .. |||.   .|.. .  |  |. .  .    |||||  | ||| ..|.|.|..|.
tlylGnakhatnekvlkdlkithivnvsqekkdafp..ksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

HLSLNEAYDFVKARKSNVSPNFNFMGQLLDFER
   |.|||...| |.| |.||  |. ||  ||.
gwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 215-349 5.6e-22 71.4 In-house 5-141 (145) alignment 
Range on Protein: 215-349
Range on HMM: 5-141/145.0
RLYLGSEKDASNIELLRKHKISYVLNVTHDRPNTFAHIEGFKYKNLPV--EDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAGISRSVTITIAYLMS
||| ||   |... .|..  || ..|..     .  .. . ... | .  ||    .|.. | |   ||| |... . |.|||.||.|||||...|.|| 
rlyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmk

SQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFERSL
   ..| ||   |....    || .|. .||..|. |
ycnmtlseaarqvrsnrllaypnvtflknllnlekql
DSPc Dual specificity phosphatase, catalytic domain 216-347 4.2e-43 141.4 Pfam-A 1-132 (133) alignment 
Range on Protein: 216-347
Range on HMM: 1-132/133.0
LYLGSEKDASnIELLRKHKISYVLNVTHDRPN-TFAHIEGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAGISRSVTITIAYLMSSQ
|||||...||  .|| |..|..|.|||.  ||  . . . ..| ..||||.  ..... ..|| .||.. .||  .||||| |||||| |..|||||...
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

HLSLNEAYDFVKARKSNVSPNFNFMGQLLDFER
.|||||||.||| |.|..|||..|..|||..||
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 216-347 4.2e-43 141.4 In-house 1-132 (133) alignment 
Range on Protein: 216-347
Range on HMM: 1-132/133.0
LYLGSEKDASnIELLRKHKISYVLNVTHDRPN-TFAHIEGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAGISRSVTITIAYLMSSQ
|||||...||  .|| |..|..|.|||.  ||  . . . ..| ..||||.  ..... ..|| .||.. .||  .||||| |||||| |..|||||...
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

HLSLNEAYDFVKARKSNVSPNFNFMGQLLDFER
.|||||||.||| |.|..|||..|..|||..||
nlslneAyefvkerrskispnagflrqLleyer
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 216-347 9.8e-30 97.0 In-house 15-145 (148) alignment 
Range on Protein: 216-347
Range on HMM: 15-145/148.0
LYLGSEKDASNIELLRKHKISYVLNVTHDRPNTFAHIeGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAGISRSVTITIAYLMSSQH
|.||| | |...| |..  .. . | |..|.|....  | .| .....|.   .|  .|... ||... ...   ||||.  |.|||  .....|.  ..
LFlGskksaadlealkalgvtrivnatkerdnaldqr.gieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkr

LSLNEAYDFVKARKSNVSPNFNFMGQLLDFER
 ||.||...|| ..  | ||  |. || ..|.
vslkealalvkskrryvdpnlgfLkqLaeleq
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 216-349 8.5e-26 84.1 In-house 10-152 (154) alignment 
Range on Protein: 216-349
Range on HMM: 10-152/154.0
LYLGSEKDASNIELLRKHKISYVLNVTHDRPNTFAHI-----EG--FKYKNLPVEDNLMANLTELFPEAFAFIDEGR--QKSSNVLVHCLAGISRSVTIT
||..| . | |  .|....|  .|||    .| |..      .|  ..| || . |.   ...| .  || |||.     . ..||||. .|.||| .. 
lyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaall

IAYLMSSQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFERSL
|.||| ....|| .|. ..|  .  ..||  |. ||  ||. |
isylmdklkislslalellkdsryiikPnqGflkqleifekel
0045450 (Phosphotyrosine protein) phosphatases II 224-348 4.1e-25 84.6 In-house 89-302 (307) alignment 
Range on Protein: 224-348
Range on HMM: 89-302/307.0
ASNI--------------------------------ELLRKHKISYVLNVTHDRPNTFA--------------------------HIEGFKYKNLPVEDN
|| .                                ..|...........|.. ....                           | .|... .|.|.|.
AsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl

-----------------LMANLTELFPEAFAFIDEGRQ------KSSNVLVHCLAGISRSVTITIAYLMSSQH--------LSLNEAYDFVKARKSNVSP
                    .. . | |...||.| |.      |.. ||||| ||..|. |. .|||| .|.        ..| ||........... .
dgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavq

NFNFMGQLLDFERS
|.... .| .... 
npeqyrflyealle
subfamily_DSP23_pd Subfamily DSP23 226-327 1.7e-07 26.0 In-house 23-123 (148) alignment 
Range on Protein: 226-327
Range on HMM: 23-123/148.0
NIELLRKHKISYVLNVTHDRPNTFAHIEGFKYKNLPVEDNLMANLtELFPEAFAFIDEGRQKSSNVLVHCLAGISRSVTITIAYLMSSQHLSLNEAYDFV
... |    . |.. .|.. .     . .  ...| ..|     | |   |    ..|  .|.  | |||| |  |. |.   ||.  ..|.  ||   |
qyrylldlgvrylvslteegrphveatpnltlvrlriddyhppal.eqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaev

KA
. 
rr
0040438 (Phosphotyrosine protein) phosphatases II 227-349 4.7e-21 70.8 In-house 103-275 (317) alignment 
Range on Protein: 227-349
Range on HMM: 103-275/317.0
IELLRKHKISYVLNVTHDRPNT-------------------------FAHIEGFKYKNLPVEDN----------------LMANLTELFPEAFAFIDEGR
.... ..........|.  ..                          . . .|... .|.|||.                   .. . . . ..|... |
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

QK----SSNVLVHCLAGISRSVTITIAYLM-----SSQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFERSL
..    .. ||||| ||..|. |. .||||       ..... ||........... ...... .| |... .
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalley
0039614 (Phosphotyrosine protein) phosphatases II 227-349 7.6e-20 67.0 In-house 118-288 (297) alignment 
Range on Protein: 227-349
Range on HMM: 118-288/297.0
IELLRKHKISYVLNVTHDRPN-----------------------TFAHIEGFKYKNLPV-----------------EDNLMANLTELFPEAFAFIDEGRQ
...............|   ..                       .. | .|... .|.|                  |.   ...||. |.. ...| ..
wrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

---KSSNVLVHCLAGISRSVTITIAYLM-----SSQHLSLNEAYDFVKARKSNVSPNFNFMGQLLDFERSL
   |.  ||||| ||..|. |. .||||     . ..... ||..... ..... ...... .| |... |
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
0051299 (Phosphotyrosine protein) phosphatases II 231-337 3.7e-13 45.0 In-house 159-273 (288) alignment 
Range on Protein: 231-337
Range on HMM: 159-273/288.0
RKHKISYVLNVTHD----RPNTFAHIEGFKYKNLPvEDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAGISRSVTITIAYLM-----SSQHLSLNEA
 .. . ..| ||.      ...  ..  | |.| | ...   ....|.    ....  ..... |.||| ||..|. |. ...|.       ..... ||
lddytvrtlevtnldlldgdgesrtvthfhytnwp.dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvlea

YDFVKARKSNVSPNFN
. ... .. .. ....
vkrlreqRpgmvqtpe
0047943 (Phosphotyrosine protein) phosphatases II 231-343 5.1e-13 44.6 In-house 147-265 (273) alignment 
Range on Protein: 231-343
Range on HMM: 147-265/273.0
RKHKISYVLNVTHDRPNTFAHIEGFKYKNLPveDNLMANLTELFPEAFAFIDEGRQ---KSSNVLVHCLAGISRSVTITIAYLM-----SSQHLSLNEAY
... . ..| .|.   .   ..  | |.. |  |.     .| . | . .... ..   ... |.||| ||..|. |. ...|.       . ... ||.
kddytvrtleltnlgtgesrtvthfhytgwp..dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleav

DFVKARKSNVSPNFNFMGQLL
 ... .. .. ...... .| 
kllrsqRpgmvqtpeqyrfly
0046845 (Phosphotyrosine protein) phosphatases II 231-334 4.3e-12 41.5 In-house 145-258 (284) alignment 
Range on Protein: 231-334
Range on HMM: 145-258/284.0
RKHKISYVLNVTHDR-PNTFAHIEGFKYKNLPvEDNLMANlTELFPEAFAFIDEGRQK---SSNVLVHCLAGISRSVTITIAYLMSSQ--------HLSL
... . ..| .|.   ..   ..  | |.. | ...  .. .| . | . ...| ...   .. ..||| ||..|. |. ...|. .|        ....
kddytvrtleltnlgytgesrtvthfhytswp.dhgvpps.pedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdv

NEAYDFVKARKSNVSP
 ||. ... .. .   
leavkrlreqRpgmvq
0050432 (Phosphotyrosine protein) phosphatases II 231-336 2e-10 36.0 In-house 178-285 (308) alignment 
Range on Protein: 231-336
Range on HMM: 178-285/308.0
RKHKISYVLNVTHDRPNTFAHIEGFKYKNLPvEDNLMANlTELFPEAFAFIDEGRqKSSNVLVHCLAGISRSVTITIAYLM-----SSQHLSLNEAYDFV
... . ..| .|. . .   ..  | |.| | ...   . .| . . . .... . ......||| ||..|. |. ...|.       ..... ||. ..
lddytvrtleltnlgdgesrtvthfhytnWp.dhgvPps.peilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkkl

KARKSNVSPNF
. .. .. ...
ReqRpgmvqtp
subfamily_RNGTT_pd Subfamily RNGTT 231-331 7.5e-06 19.7 In-house 51-157 (189) alignment 
Range on Protein: 231-331
Range on HMM: 51-157/189.0
RKHKISYVLNVTHDRP-NTFAHI--EGFKYKNLPVEDNLMANLTELFPEAFAFIDE--GRQKSSNVLVHCLAGISRSVTITIAYLMSSQHLSLNEAYD-F
.|.|. .|...|....  .  ..  || ||..| .. .  |  .|   |    ..|   .. .. . |||  |  |.  . ..||.  .. |...| . |
lkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalF

VKARKSN
 |||.  
akaRppG
0043336 (Phosphotyrosine protein) phosphatases II 232-347 9.8e-17 56.8 In-house 155-274 (278) alignment 
Range on Protein: 232-347
Range on HMM: 155-274/278.0
KHKISYVLNVTHDRPNTFAHIEGFKYKNLPvEDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAGISRSVTITIAYLM-----SSQHLSLNEAYDFVK
.. . ..|.||. . .   .. .. |.. | ....  .|. |.    |...  . ... ||||| ||..|. |. ..||.     . ....| ||.....
ddytvrtlevtnlgdgesrtvthyhylgwp.dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelr

ARKSNVSPNFNFMGQLLDFER
 .. .  ...... .| ....
eqRpgavqtpsqyrflyeall
subfamily_PTEN_pd Subfamily PTEN 232-328 4.8e-06 21.7 In-house 57-155 (184) alignment 
Range on Protein: 232-328
Range on HMM: 57-155/184.0
KHKISY-VLNVTHDRPNTFAHIEGfKYKNLPVEDNLMANLtELFPEAFAFIDEGRQ--KSSNVLVHCLAGISRSVTITIAYLMSSQHLSLN-EAYDFVKA
||| .| ..|.. .|    ....| . . .|..|.  ..| ||. |.   |..  .  |.  | ||| ||  |. ....|||. |..|. . || .. ..
khkdhykiynlrserkydskkfdg.rvavypfdDhnpppl.elleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfae

R
 
a
Y_phosphatase Protein-tyrosine phosphatase 234-316 9.6e-07 23.8 Pfam-A 116-198 (235) alignment 
Range on Protein: 234-316
Range on HMM: 116-198/235.0
KISYVLNVTHDRPNT-FAHIEGFKYKNLPvEDNLMANLTELFpeafAFIDEGRQKS----SNVLVHCLAGISRSVTITIAYLMSSQHL
 . ..|.....  ..   ... . |.| | . .. .. ..|.     .|.. ....    ..|.||| ||..|. |.  . .. .|  
ytlrklelkkkkeesekrevkqlhytnWp.dhgvpespksll....dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle
Y_phosphatase Protein-tyrosine phosphatase 234-316 9.6e-07 23.8 In-house 116-198 (235) alignment 
Range on Protein: 234-316
Range on HMM: 116-198/235.0
KISYVLNVTHDRPNT-FAHIEGFKYKNLPvEDNLMANLTELFpeafAFIDEGRQKS----SNVLVHCLAGISRSVTITIAYLMSSQHL
 . ..|.....  ..   ... . |.| | . .. .. ..|.     .|.. ....    ..|.||| ||..|. |.  . .. .|  
ytlrklelkkkkeesekrevkqlhytnWp.dhgvpespksll....dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle
subfamily_PTPMT1_pd Subfamily PTPMT1 237-346 4.7e-16 53.7 In-house 57-165 (171) alignment 
Range on Protein: 237-346
Range on HMM: 57-165/171.0
YVLNVTHDRPNTFAHIeGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAGISRSVTITIAYLMSSQHLSLNEAYDFVKARKSNVSPNF
| |..  .  ... .  | .. .|.. |   |  .|   ..  ||.. ..| . | ||| || .|| |. ..||| ...||..|| ...|.... .  . 
yelkalansteewkkl.gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlak

NFMGQLLDFE
. . .|  .|
kqwkalqeye
subfamily_Laforin_pd Subfamily Laforin 251-329 3.1e-08 26.7 In-house 73-151 (183) alignment 
Range on Protein: 251-329
Range on HMM: 73-151/183.0
HIEGFKYKNLPVEDNLMANLTELFPEAFAFIDEGRQKSSNVLVHCLAGISRSVTITIAYLMSSQHLSLNEAYDFVKARK
. ||. |  ||.||    .  | .|.|  ..    .|   | ||| ||. || .|   .|.   . ||.    |. |..
keeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakr
PTPc_DSPc_SM00012 276-319 4.1e-07 25.5 In-house 31-70 (105) alignment 
Range on Protein: 276-319
Range on HMM: 31-70/105.0
EAFAFIDEgrqkSSNVLVHCLAGISRSVTITIAYLMSSQHLSLN
.    ...    |..|.||| ||..|. |.. .... .|. . .
knknkses....skpvvVhCsaGvgRtgtfvaldillqqleket