Gene DSP8 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP8
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP013_AA protein Get Run
NvecP013_AA_150-297 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 17-121 6e-13 41.3 Pfam-A 9-111 (113) alignment 
Range on Protein: 17-121
Range on HMM: 9-111/113.0
V--QSLLIIDSRSFLEYNDAHVINSINIGCSKLIKRRLITNKISIQELLKTGENVQPNQLgKVIVYDqdtqDMEGLSKDNFMSVVFSKLTS-SYKDVCFL
   ......| ||. ||.  |. ...|.  . | .||  . |  ..| |.. ..  ..   .|.||.     .   |.  . ...  .| . .||.|..|
lekekvvllDvRspeeyakghIpgAvnvpldslyprrdlffkdklaeeleesgkkldkdk.tvvvyc....rsgnrsggaaalllalilkelgyknvyvL

KGGFSFFA
.|||. ..
dGGfeawk
subfamily_DSP8_pd Subfamily DSP8 143-297 5e-74 241.1 In-house 3-158 (159) alignment 
Range on Protein: 143-297
Range on HMM: 3-158/159.0
LSQPCLSTEA--PTHILPFLYLGTQEHSLDEEFLNATGINYVLNISCSCPALPGLENTGrYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCY
|||||||...  ||.||..||||.|...|.||.|...||.||||.|.|||.|  |...  .||.||||...|..|.||.....||||... .||||.|..
lsqPCLsvadvgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkesk.flrvPvkDkydekllpwfdksvefidkaksengrvlvhvl

AGKSRSATIAIGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDLMITT
||.|||||.||.||||.|..|||||||||||.||||||||||.|||..|||.|...|
aGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelkllt
PTEN_1 144-293 2.1e-28 94.5 In-house 37-191 (196) alignment 
Range on Protein: 144-293
Range on HMM: 37-191/196.0
SQPCLSteaptHILPFLYLGTQEHS-LDEEFLNATGINYVLNISCSCPAlPG--------LENTGRYLRIPVKDTINENILDWFPTAFDFIDKVRE--VH
|.|.|.     .| ..||.| ...   | . | . ||  |.| |. ..  .|         ..  .||..|..|    ..  .|  . .||. ...   .
srpllq.....eideglyrgslkdvaadldnlkedgitlvvnlseeeel.sgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpng

GRVLLHCYAGKSRSATIAIGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
. || || ||..||.|... | |.. .|. ||| ..|.|.|| ..||  .. .|..|...|
nvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael
0045098 (Phosphotyrosine protein) phosphatases II 145-293 4.9e-24 80.6 In-house 14-271 (278) alignment 
Range on Protein: 145-293
Range on HMM: 14-271/278.0
QPCLSTEAPTHILPFLYLGTQE-----------------------------------------HSLDEEFLNATGINYVLNISCSCPA------------
.  |..  |  |.|.|||| ..                                         .. . ..|   ||......    .             
efllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeg

-----------------------------------LPGLENTGR---YLRIPVKDTINENILDWFPTAFDFIDKVRE--------------VHGRVLLHC
                                     . ... .   || .|  .. ...||..|  ...||.....               .|.|| ||
gsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC

YAGKSRSATIAIGYIMKHL---RLSLDEAYRFVKERRPT-ISPNLNFMGQLMQYEKDL
.||..|..|... |.|..|   ...|.||.......||  . .||... .|.... .|
saGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel
subfamily_DSP10_pd Subfamily DSP10 148-294 3.1e-55 180.4 In-house 9-154 (159) alignment 
Range on Protein: 148-294
Range on HMM: 9-154/159.0
LSTEAPTHILPFLYLGTQEHSLDEEFLNATGINYVLNISCSCPALPGLeNTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSA
. |   ...||||.|| .. . |.. |.  .|..|||. .|.|      .. .| ||||.|| ..|.   |  |..||...|.   |||.|| || ||||
ietapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsa

TIAIGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDLM
|..|.|.||||.||| .||.||||.||.|||||||||||...||.| 
tvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekeln
subfamily_LRR-DSP_pd Subfamily LRR-DSP 148-296 1.6e-30 100.1 In-house 115-261 (263) alignment 
Range on Protein: 148-296
Range on HMM: 115-261/263.0
LSTEAPTHILPFLYLGTQEHSLDEEFLNATGINYV-LNISCSCPALPgleNTGRYLRI-PVKDTINENILDWFPTAFDFIDKVREvHGRVLLHCYAGKSR
| .  |  |.. |.||... . .. .|.  |. .. | ..   |  |   .. .|| |  ..|. . .|  .|     ||.. |. .| ||.|| || ||
lvssvPdeiidklflGgldsannksilkdlgvthillavadfePlfP...klfkylsiddiedvdeadisqhfeetnafieeGrk.kGGvlvhcraGvsr

SATIAIGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDLMIT
|.|. | |.||. || . ||. .|...|| | ||  |. ||..|||.|. |
sstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfct
subfamily_DSP6_pd Subfamily DSP6 150-295 5.3e-50 163.0 In-house 11-156 (158) alignment 
Range on Protein: 150-295
Range on HMM: 11-156/158.0
TEAPTHILPFLYLGTQEHSLDEEFLNATGINYVLNISCSCPALPGLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATI
.|.| .|||.||||..... . | |.  .|.||||.    |     ..  .||.||..| ...|.  .|| |..|||. |. .  ||.||.|| ||| |.
aefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtv

AIGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDLMI
.. |.||.| |||..|| .||.|.. ||||.||||||...|. | .
tlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrl
subfamily_Slingshot_pd Subfamily Slingshot 150-293 1.8e-34 112.6 In-house 16-157 (169) alignment 
Range on Protein: 150-293
Range on HMM: 16-157/169.0
TEAPTHILPFLYLGTQEHSLDEEFLNATGINYVLNISCSCPALpgLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATI
 .....|  ..|||..  . . | |. .|..|.||... .      ... .||.| | |. ....|... ....||.|... . .||.||  | ||||..
ldsaskifdhvylGsewnasnleelkengveyilnvtkeidnf..fpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsast

AIGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
 | | ||. .|||.||...|||||  | || .|. || .||  |
viayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGil
subfamily_DSP1_pd Subfamily DSP1 152-297 1.1e-46 152.9 In-house 16-160 (163) alignment 
Range on Protein: 152-297
Range on HMM: 16-160/163.0
APTH-ILPFLYLGTQEHSLDEEFLNATGINYVLNISCSCPALpgLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIA
 |.. ||.|||||..... . |.|...||  .||.| ...     |.. .| .....|. ...|  .| .. .|||.|.. .|.||.|| || |||.|. 
dPvekildfLylGsetvasnleiLkslgitailnvskeldnv..fedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlc

IGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDLMITT
. |.||. |.||.||. |||.||. ||||..|..||..|||.|. ..
laylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklllel
0044763 (Phosphotyrosine protein) phosphatases II 152-294 1.2e-38 127.8 In-house 22-171 (178) alignment 
Range on Protein: 152-294
Range on HMM: 22-171/178.0
APTHILPFLYLGTQEHSLDEEFLNATGINYVLNISCSC-------PALPGLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVR-EVHGRVLLHCYAGK
 ...|||.||||.. .. | |.| . ||....|..  .       ..    |.  .||.||. |  . ..|..|. ...||.... | .|.|| ||.||.
naseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGv

SRSATIAIGYIMKHLRLSLDEAYRFVKERRPtISPNLNFMGQLMQYEKDLM
.||.|... |.||.|.|||.||...|.|||| |.|| ... ||...|. |.
gRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll
0041856 (Phosphotyrosine protein) phosphatases II 152-294 1.2e-31 105.1 In-house 18-173 (182) alignment 
Range on Protein: 152-294
Range on HMM: 18-173/182.0
APTHILPFLYLGTQEH--------------SLDEEFLNATGINYVLNISCSCPALPGLENTG-RYLRIPVKDTINENildwFPTAFDFIDKVREVHGRVL
 .. |.. |||| . .                . ..|   ||....|... .     ||..| .||..|. |    .    .....|||..|.| .|.||
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvl

LHCYAGKSRSATIAIGYIMKHLRLSLDEAYRFVKERRP--TISPNLNFMGQLMQYEKDLM
 || ||..|..|... |.||.|..||.||...|..|||   |.|| .|. ||. .|. | 
VHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll
0046846 (Phosphotyrosine protein) phosphatases II 152-292 4.6e-26 87.1 In-house 11-171 (176) alignment 
Range on Protein: 152-292
Range on HMM: 11-171/176.0
APTHILPFLYLGTQE----------HSLDEEFLNATGINYVLNISCS-------CPALPGL--ENTGRYLRIPVKDTINENIlDWFPTAFDFIDKVREVH
 .. |.. |.||             .  . |.|   ||..|.|.          || .. .  ..  .||..|. |    .. ........||..... .
dldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeg

GRVLLHCYAGKSRSATIAIGYIMKH-LRLSLDEAYRFVKERRP-TISPNLNFMGQLMQYEKD
|.|| ||.||..|..|... |....   ||..||...|.|.||  . .. ... .|...|. 
gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
PTPc_motif_SM00404 153-291 1.3e-40 133.5 In-house 2-139 (140) alignment 
Range on Protein: 153-291
Range on HMM: 2-139/140.0
PTHILPFLYLGTQEHSLDEEFLNATGINYVLNISCSCPALpgL-ENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAI
|. ||| ||||..... ....|.. || .|.|.. ....     ..  ..|.||..|. ......... . |||..... .|.|| ||.|| |||||..|
psrilphlylgskskaqnpallkklgithvinvteevslt..kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatlii

GYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEK
 |.|.   |||.|||.|||||||.|||||||. ||..|||
aYlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
0048179 (Phosphotyrosine protein) phosphatases II 153-291 5.2e-35 115.6 In-house 4-142 (144) alignment 
Range on Protein: 153-291
Range on HMM: 4-142/144.0
PTHILPFLYLGTQEHSLDEEFLNATGINYVLNISCSCPALPGLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIG
|. ||| |||| . ..|| |.| . ||..|.|.. ...      .  .||..|. |    ..|........||....| .|.|| ||.||..|..|... 
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEK
|.||.|.|||.||...|..||| . || ... .|..|||
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
0048076 (Phosphotyrosine protein) phosphatases II 153-293 4.1e-34 112.7 In-house 4-142 (145) alignment 
Range on Protein: 153-293
Range on HMM: 4-142/145.0
PTHILPFLYLGTQEHSLDEEFLNATGINYVLNISCSCPALPglENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIG
|. ||| |||| . . || |.|   || .|||... .. |   ..  .||..|. |    ..|........||..... .|.|| ||.||..|..|... 
pseilpglylgslptaldlellkdlgittvlnltselelle..rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

YIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
|.|..|..||.||...|...|| . || ... .|...|. |
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0043147 (Phosphotyrosine protein) phosphatases II 153-294 1.5e-30 101.5 In-house 19-161 (172) alignment 
Range on Protein: 153-294
Range on HMM: 19-161/172.0
PTHILPFLYLGTQEHSLDEEFLNATGINYVLNIScSC--PALPGLENTGRYLRIPVKDTINEnILDWFPTAFDFIDK--VREVHGRVLLHCYAGKSRSAT
|..........   .. . ..|   ||....|.  ..  .. .  ..  .||..|. |     .|.... ...|||.  ... .|.|| ||.||..|..|
pdrfiatqgplrntladfwrmlkelgithivnlt.ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgt

IAIGYIMKhLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDLM
... |.|. |.|||.||...|.|.|| ...| ... .|...|| |.
lvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklll
0049260 (Phosphotyrosine protein) phosphatases II 153-292 6.9e-29 95.9 In-house 8-148 (152) alignment 
Range on Protein: 153-292
Range on HMM: 8-148/152.0
PTHILPFLYLGTQEHSLDEEFLNATGINYVLNISCSCP-ALPGLENTGRYLRIPVKDTINENILDWFPTAFDFIDK-VREVHGRVLLHCYAGKSRSATIA
|.........| . .. . ..|   ||......   .. . .. |.  .||..|. |    .. .... ...||.|  .. .|.|| ||.||..|..|..
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

IGYIMKhLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKD
. |.|. |..||.||...|.|.|| . || ... .|...|| 
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekl
subfamily_STYXL1_pd Subfamily STYXL1 153-294 2.8e-24 79.1 In-house 11-154 (157) alignment 
Range on Protein: 153-294
Range on HMM: 11-154/157.0
PTHILP-FLYLGTQEHSLDEEFLNATGINYVLNISCSC-PALPGLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIA
|  .|| .||||. ... ...  .   .  ..|.|  . . . |.... . |.|.|.|. . ..|. .  | .||.| ..    ||.    | ||||...
PvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaavi

IGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDLM
|.|.| . ...| .|| ..|. .. . || .|. || ..||.|.
iaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqll
subfamily_DSP14_pd Subfamily DSP14 154-297 1.7e-38 126.0 In-house 8-148 (157) alignment 
Range on Protein: 154-297
Range on HMM: 8-148/157.0
THILPFLYLGtQEHSLDEEFLNATGINYVLNISCSCPAlPGLENTGrYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGY
..| | |.|.    .|..| |....|. ..|..   |. . |..   ....||.|. .... ..| .. | |..|.. .|..|.||.|| ||||.... |
sqitpsLfls.gvaalskellkkkkitliinvtvelpn.tklkdie.rvkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclay

IMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDLMITT
.||. .||| |||. ||..|| |.||. |  ||..||| |  ..
lmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgks
0036282 (Phosphotyrosine protein) phosphatases II 154-291 3.7e-24 80.8 In-house 13-167 (174) alignment 
Range on Protein: 154-291
Range on HMM: 13-167/174.0
THILPFLYLGTQEHSlDEEFLNATGINYVLNISCSCPAL-------------PGLENTGRYLRIPVKDTINENILDwFPTAFDFIDKVREV--HGRVLLH
..|.| |..|   .. . |.|   ||..|..   ...                  ..  .||..|. |    ..   . ....|......   .| || |
syitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

CYAGKSRSATIAIGYIMKHLRL-SLDEAYRFVKERR---PTISPNLNFMGQLMQYEK
| ||..|..|... |.|... | ||..|...|.|.|   | . .. ... .| ..||
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
subfamily_DSP19_pd Subfamily DSP19 155-293 2.2e-38 126.0 In-house 14-150 (152) alignment 
Range on Protein: 155-293
Range on HMM: 14-150/152.0
HILPFLYLGTQEHSLDEEFLNATGINYVLNISCSCPALpgLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYI
.. | |||| |.   |.| |. ..| ..||..   | .    .   || |.. |. ....|.....|.|||...|. .|.||.|| || ||||...|.|.
eveprlylgsqdvaadkeilkekkitHilnvatgvpnv..fpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviayl

MKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
||. .||| ||.. |.| ||.|.||  |. || .||. |
mkkeelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP12_pd Subfamily DSP12 155-294 5.3e-34 111.9 In-house 4-144 (155) alignment 
Range on Protein: 155-294
Range on HMM: 4-144/155.0
HILPFLYLGTQEHSLDEEFLNATGINYVLNISCS-CPALPGLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGY
.||| ||||. |.  .||.|. ..|. || .     |     ... ... |.. |. .|.||.....|.|||.. .| .| || ||.|| |||.|| | |
rilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

IMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDLM
.||. .|||..|...||| .|.|.|| .|. ||  .||  .
lmkkeklslekAlklvkekkpeiepNegFleQLklfekmgc
subfamily_DSP15_pd Subfamily DSP15 155-292 7.3e-29 94.8 In-house 4-138 (151) alignment 
Range on Protein: 155-292
Range on HMM: 4-138/151.0
HILPFLYLGTQEHSLDEEFLNATGINYVLNISCscPALPGLENtGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYI
..|| ||||  . | ||| |. . |  .|...    | . |..  .|. |...|| . ..  .|  . .|| | |   . ||.|| || |||.|... |.
kvlpglylgnfrdskdeelLkeknithilsvhd..nakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKD
|  . |.  .| ...|..| .  ||. |  ||..||| 
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt
subfamily_DSP3_pd Subfamily DSP3 155-294 2.5e-28 92.7 In-house 13-158 (162) alignment 
Range on Protein: 155-294
Range on HMM: 13-158/162.0
HILPFLYLGTQEHSLDEEFLNATGINYVLNISCScpAL----PG----LENTGRYLRIPVKDTINENILDWFPTAFDFIDKV-REVHGRVLLHCYAGKSR
 . | ||.| .. . |.. |.. || .||| . .   .     |     .   .|| ..|.|. . ..  .| ||..|||.   . .|.||.|| .| ||
evypklyvgdeavakdkskLkklGithvlnaaeg..rfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsR

SATIAIGYIMKHLRLSLDEAYRFVKERRpTISPNLNFMGQLMQYEKDLM
|||... |.| . ...| || | |...| .| ||  |. ||......|.
satlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeelk
subfamily_STYX_pd Subfamily STYX 155-293 5.5e-28 91.1 In-house 14-157 (166) alignment 
Range on Protein: 155-293
Range on HMM: 14-157/166.0
HILPFLYLGTQEHSLD--EEFLNATGINYVLNISCSCPA---LPGLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATI
.||| |.||    ..    | |.  || ... |  .  |    | .... ||| . | |.  |||. ..||  .|||.  .  |.||.|  || ||||..
eilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal

AIGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
 |.|||.   |   ||...|.|||  |.||  |. ||..||   
viayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiy
0037934 (Phosphotyrosine protein) phosphatases II 155-293 2.5e-23 78.3 In-house 41-241 (243) alignment 
Range on Protein: 155-293
Range on HMM: 41-241/243.0
HILPFLYLGTQ--------EHSLDEEFLNATGINYVLNISCSC------------------------------------------PA-LPGLENTGRYLR
 ..| |... .         .  . ..|   ||......   .                                          .   .   .  .|..
yvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

IPVKD----TINENILDWFPTAFDFIDK-----VREVHGRVLLHCYAGKSRSATIAIGYIMKHL-RLSLDEAYRFVKERRPT-ISPNLNFMGQLMQYEKD
.|. |    .  |..||..  . .||..     ..  .|.||.||.||..|..|... |.|..| ...|.||.....|.||  . ...... .|..... 
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyealle

L
|
l
0051082 (Phosphotyrosine protein) phosphatases II 155-290 3.2e-22 74.2 In-house 10-150 (151) alignment 
Range on Protein: 155-290
Range on HMM: 10-150/151.0
HILPFLYLGTQEHSLDEEFLNATGINYVLNISCSCPALPGL----ENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREV-HGRVLLHCYAGKSRSATI
 . ..||.. . .. . |.|   ||....|.    .         |.  ..|.||. |. . .. ..|... .|......  .| || || |||.|..|.
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtl

AIGYIMKhLRLSLDEAYRFVKERRP-TISPNLNFMGQLMQYE
.. |.|. |..||.||.......||  . ||  |. ||....
valylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfall
0042113 (Phosphotyrosine protein) phosphatases II 156-293 1.8e-21 72.1 In-house 50-242 (245) alignment 
Range on Protein: 156-293
Range on HMM: 50-242/245.0
ILPFLYLGTQEHSLDEE----FLNATGINYVLNISCSCP--------------------------------------------ALPGLENTGRYLRIPVK
| | .... . .. . |    .|   ||.......   .                                              .   .  .|...|. 
itpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp

DTINENILDWFPTAFDFIDKVRE--VHGRVLLHCYAGKSRSATIAIGYIM-----KHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
|    ..|...  ...|..|...   .|.|| || ||..|..|... |.|     |.|..||.||.......|| . ...... .|......|
dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 157-291 2.8e-29 95.5 In-house 11-145 (148) alignment 
Range on Protein: 157-291
Range on HMM: 11-145/148.0
LP-FLYLGTQEHSLDEEFLNATGINYVLNISCSCPALpgLENTG-RYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYI
 . ||.|| ... .| | |.| |.  . | . ...    |.. | .|| ....|  .|..   |... .|..|...  .|||.|.  | |||. .|. ..
kdafLFlGskksaadlealkalgvtrivnatkerdna..ldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwl

MKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEK
... | || ||. .||..|. . ||| |. || ..|.
idfkrvslkealalvkskrryvdpnlgfLkqLaeleq
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 157-293 5.3e-29 94.5 In-house 7-152 (154) alignment 
Range on Protein: 157-293
Range on HMM: 7-152/154.0
LPFLYLGTQEHSLDEEFLNATGINYVLNISCSCPALPGLE----NTG---RYLRIPVKDTINENILDWFPTAFDFIDKVR-E-VHGRVLLHCYAGKSRSA
  |||..... .|.   |.   |. .||..   . |   |    | |    ||.. . | .| .|.. .  ||.|||.      ...||.|. .| ||||
aiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsa

TIAIGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
...|.|.|..|..|| .|. ..|. |. |.||  |. || ..||.|
allisylmdklkislslalellkdsryiikPnqGflkqleifekel
0051429 (Phosphotyrosine protein) phosphatases II 158-299 3e-20 68.5 In-house 21-230 (272) alignment 
Range on Protein: 158-299
Range on HMM: 21-230/272.0
PFLYLGTQE----HSLDEEFLNATGINYVLNISCSC-------PALPgleNTGRYLRIPVKDTINENILDWF----------------------------
| ... ..        | ..|   ||......   .       . ..      |||..|. |.  . || ..                            
pgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdryw...pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsag

--------------------PTAFDFIDKVREvHGRVLLHCYAGKSRSATIAIGYIMKhLRLS--------------LDEAYRFVKERRPTISPNLNFMG
                     .  .... ... .|.|| ||.|||.|..|..  ...  |..|              |.||.. ....|| . ..  .. 
earevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqyl

QLMQYEKDLMITTTE
.|......|. . ..
flyeallellrslls
subfamily_MKPLT_pd Subfamily MKPLT 159-291 6.4e-26 84.8 In-house 28-158 (164) alignment 
Range on Protein: 159-291
Range on HMM: 28-158/164.0
FLYLGTQEHSLDEEFLNATGINYVLNISCSCpaLPGLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYIMKHL
 ||||  .|. .|. |..  |....|.|  .  .    ..  ||.. |.|. .|.. ...  | .|. .  .  ||||.||  |||||..... ...|  
tlylGnakhatnekvlkdlkithivnvsqek..kdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

RLSLDEAYRFVKERRPTISPNLNFMGQLMQYEK
.  |.||| ..||||  ..||  |. || ..|.
gwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 159-291 6.4e-26 84.8 In-house 28-158 (164) alignment 
Range on Protein: 159-291
Range on HMM: 28-158/164.0
FLYLGTQEHSLDEEFLNATGINYVLNISCSCpaLPGLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYIMKHL
 ||||  .|. .|. |..  |....|.|  .  .    ..  ||.. |.|. .|.. ...  | .|. .  .  ||||.||  |||||..... ...|  
tlylGnakhatnekvlkdlkithivnvsqek..kdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

RLSLDEAYRFVKERRPTISPNLNFMGQLMQYEK
.  |.||| ..||||  ..||  |. || ..|.
gwtlkeayeylkerrsivapnrGflkqlakfee
DSPc Dual specificity phosphatase, catalytic domain 160-291 5.3e-39 128.1 Pfam-A 1-132 (133) alignment 
Range on Protein: 160-291
Range on HMM: 1-132/133.0
LYLGTQEHSLdEEFLNATGINYVLNISCSCPAL-PGLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYIMKHL
||||.....  ...|.. ||..|.|.. ..|.     ..  .||||||.|. ...| .... | .||.|... ...|| ||.|| |||||..| |.||  
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RLSLDEAYRFVKERRPTISPNLNFMGQLMQYEK
.|||.|||.||||||..|||| .|..||..||.
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 160-291 5.3e-39 128.1 In-house 1-132 (133) alignment 
Range on Protein: 160-291
Range on HMM: 1-132/133.0
LYLGTQEHSLdEEFLNATGINYVLNISCSCPAL-PGLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYIMKHL
||||.....  ...|.. ||..|.|.. ..|.     ..  .||||||.|. ...| .... | .||.|... ...|| ||.|| |||||..| |.||  
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RLSLDEAYRFVKERRPTISPNLNFMGQLMQYEK
.|||.|||.||||||..|||| .|..||..||.
nlslneAyefvkerrskispnagflrqLleyer
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 160-293 4e-19 62.1 In-house 6-141 (145) alignment 
Range on Protein: 160-293
Range on HMM: 6-141/145.0
LYLGTQEHSLDEEFLNATGINYVLNISCSCpALPGLENTG---RYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYIMK
|| |.  |. |   |.  ||  ..|.. .  ..   |  .     | |  .|    .. . |    ||||| .|    |..|| || ||| |... ..||
lyvgsalhandvptlqelgisrivnmaags.lvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmk

HLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
.  ..| || | |. .|    ||..|. .|.. ||.|
ycnmtlseaarqvrsnrllaypnvtflknllnlekql
0049772 (Phosphotyrosine protein) phosphatases II 165-293 1.7e-33 112.1 In-house 157-273 (314) alignment 
Range on Protein: 165-293
Range on HMM: 157-273/314.0
QEHSLDEEFLNatginyvlniSCSCPAlPGLENT-GRYLRIPVKDtINENILDWFPTAFDFIDKVrEVHGRVLLHCYAGKSRSAT-IAIGYIMKHLRLSL
. .  | |.|.          .. ... . .|..  .|||||| |  ....|..|. ...||... . .|.|| || |||.|..| ....|.||.|..||
eptaadlellk..........eelydp.elferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsl

DEAYRFVKERRPtISPNLNFMGQLMQYEKDL
.||...|...|| |.|| .|. ||.|||. |
eealedvrlkRp.inpnpgfieqleqyefil
0050432 (Phosphotyrosine protein) phosphatases II 169-281 2.5e-12 42.2 In-house 44-286 (308) alignment 
Range on Protein: 169-281
Range on HMM: 44-286/308.0
LDEEFLNATGINYvlNISCSCPALPGLENTGRYLRIPVKDT-----------INENILDW----------------------------------------
|.|||   . .    ....|. .||   .  ||  |.  |            || .  |                                         
leeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtk

--------------------------------------------------------------------------FPTAFDFIDKVREV--HGRVLLHCYA
                                                                          .   .||...||..  .| .. || |
lvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsa

GKSRSATIAIGYIM-----KHLRLSLDEAYRFVKERRPTISPNLN
| .|..|... ...     |. .... ||.....|.||   ....
GvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe
subfamily_DSP23_pd Subfamily DSP23 172-276 4.8e-06 21.3 In-house 25-128 (148) alignment 
Range on Protein: 172-276
Range on HMM: 25-128/148.0
EFLNATGINYVLNISCSCPALPGLENTGRYLRIPVKDTInENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYIMKHLRLSLDEAYRFVKE
..|   |. |.. ..  ..       .  . |. ..|      |.        ...  |    | .||  |. |. |.   |..|. .|.  ||   |..
rylldlgvrylvslteegrphveatpnltlvrlriddyh.ppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrr

RRPTI
.||  
lrpgs
0040439 (Phosphotyrosine protein) phosphatases II 178-293 4.2e-23 77.7 In-house 78-245 (249) alignment 
Range on Protein: 178-293
Range on HMM: 78-245/249.0
GINYVLNISCSCPA--------LP---------------------------------GLENTGRYLRIPVKDTINENILDWFPTAFDFIDKVRE------
||.......  ..          |                                 .  .. ..| |.. |    .. ..|....|||..||.      
gitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelp

VHGRVLLHCYAGKSRSATIAIGYIM-----KHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
 .|.|| || ||..|..|... |.|     |.|...|.||.......|| . .|.... .|......|
kggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0038934 (Phosphotyrosine protein) phosphatases II 196-293 2.7e-20 68.3 In-house 77-176 (194) alignment 
Range on Protein: 196-293
Range on HMM: 77-176/194.0
ENTGRYLRIPVKDTIN----ENILDWFPTAFDFIDKvrEVHGRVLLHCYAGKSRSATIAIGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEK
..  .||..|..| ..    |..|...  . .|...    .| |. ||.||..|..|... |....|..|..||.....|.|| . || ... .|... |
kagieylklpfpddgtvPsleillrfldlvdeflne..dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkryk

DL
.|
el
0043336 (Phosphotyrosine protein) phosphatases II 197-292 1e-16 56.7 In-house 176-275 (278) alignment 
Range on Protein: 197-292
Range on HMM: 176-275/278.0
NTGRYLRIPvKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYIM-----KHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEK
.   || .|  ... |.. . .    .......  .| || || ||..|..|... |..     |.....|.||.....|.|| . ...... .| ....
thyhylgwp.dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall

D
.
e
0045450 (Phosphotyrosine protein) phosphatases II 199-293 3.5e-23 78.2 In-house 178-303 (307) alignment 
Range on Protein: 199-293
Range on HMM: 178-303/307.0
GRYLRIPVKDT-----------------INENILDWFPTAFDFIDKVRE------VHGRVLLHCYAGKSRSATIAIGYIMKHLR--------LSLDEAYR
  .....|.|.                  . .. ..| ...|||..||.       .|.|| || ||..|..|... |.|....        ..|.||..
ytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavk

FVKERRPTISPNLNFMGQLMQYEKDL
...|.|| . .|.... .|......|
llreqRpgavqnpeqyrflyeallel
0040438 (Phosphotyrosine protein) phosphatases II 199-301 4.4e-22 74.2 In-house 156-283 (317) alignment 
Range on Protein: 199-301
Range on HMM: 156-283/317.0
GRYLRIPVKDT----------------INENILDWFPTAFDFIDKVREV----HGRVLLHCYAGKSRSATIAIGYIM-----KHLRLSLDEAYRFVKERR
  .....|.|.                   .. ... . .||...|||.    .| || || ||..|..|... |.|     |. .....||.....|.|
itlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqR

PTISPNLNFMGQLMQYEKDLMITTTEKK
| . ...... .|.... ... ..  ..
pgavqtpeqyrflydalleylkrkltle
subfamily_Laforin_pd Subfamily Laforin 200-276 3.3e-08 26.6 In-house 78-154 (183) alignment 
Range on Protein: 200-276
Range on HMM: 78-154/183.0
RYLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYIMKHLRLSLDEAYRFVKERRPTI
 |. .|..|   |. .. .| |  ..  . |   .| .|| ||  ||..|  |...  |  ||     |.  .||..
ayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv
subfamily_PTPMT1_pd Subfamily PTPMT1 201-293 1.5e-19 65.1 In-house 76-168 (171) alignment 
Range on Protein: 201-293
Range on HMM: 76-168/171.0
YLRIPVKDTINENILDWFPTAFDFIDKVREVHGRVLLHCYAGKSRSATIAIGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
.|.....|  ..  |.    . .||.||..   || .|| ||..||||... |.||. .||..|| ...|..|..|  . . . .| .||. |
qlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekl
0039614 (Phosphotyrosine protein) phosphatases II 203-293 4.4e-19 64.5 In-house 190-288 (297) alignment 
Range on Protein: 203-293
Range on HMM: 190-288/297.0
RIPVKDTINENILDWFPTAFDFIDKVRE---VHGRVLLHCYAGKSRSATIAIGYIM-----KHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
 ..  |    ..|. .  ..........    .|.|| || ||..|..|... |.|     |. .....||.....|.|| . ...... .|......|
ytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
0051299 (Phosphotyrosine protein) phosphatases II 204-282 6.3e-13 44.3 In-house 58-274 (288) alignment 
Range on Protein: 204-282
Range on HMM: 58-274/288.0
IPVKDT----------------------------------------------------------------------------------------------
|.  |                                                                                               
ilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllsee

-----------------------------------INENILDWFPTAFDFIDKVREV----HGRVLLHCYAGKSRSATIAIGYIM-----KHLRLSLDEA
                                    . .. | .   .||. .||..    .| |. || ||..|..|... ...     |. .... ||
vlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvlea

YRFVKERRPTISPNLNF
.....|.|| . .... 
vkrlreqRpgmvqtpeq
0036941 (Phosphotyrosine protein) phosphatases II 206-296 3e-20 68.2 In-house 175-279 (297) alignment 
Range on Protein: 206-296
Range on HMM: 175-279/297.0
VKDTINENILDWFPTAFDFIDKVRE------VHGRVLLHCYAGKSRSATIAIGYIM--------KHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEK
...    .. ... . .|||..||.       .|.|| || ||..||.|... ..|        |. .... ||.....|.|| . ..|... .| ... 
ytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeall

DLMIT
.|  .
ellkk
0047943 (Phosphotyrosine protein) phosphatases II 211-288 1.5e-14 49.6 In-house 178-266 (273) alignment 
Range on Protein: 211-288
Range on HMM: 178-266/273.0
NENILDWFPTAFDFIDKVRE------VHGRVLLHCYAGKSRSATIAIGYIM-----KHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQ
. .. . .   ..||..||.       .| |. || ||..|..|... ...     |. .....||.......|| . ...... .|..
dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflye
0046845 (Phosphotyrosine protein) phosphatases II 212-281 1.2e-11 40.0 In-house 178-261 (284) alignment 
Range on Protein: 212-281
Range on HMM: 178-261/284.0
ENILDWFPTAFDFIDKVREV------HGRVLLHCYAGKSRSATIAIGYIMKHL--------RLSLDEAYRFVKERRPTISPNLN
 .. . .   ..|...|||.      .| .. || ||..|..|... ......        .... ||.....|.||    .| 
hgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle
0048567 (Phosphotyrosine protein) phosphatases II 217-280 8e-09 30.1 In-house 59-125 (157) alignment 
Range on Protein: 217-280
Range on HMM: 59-125/157.0
WFPTAFDFIDKVREVHGRVLLHCYAGK---SRSATIAIGYIMKHLRLSLDEAYRFVKERRPTISPNL
..  . .|.. ... .... .||.||    .|.||..  |...||... .||.....  ||.. |  
FilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfr
subfamily_MSG5_pd Subfamily MSG5 224-293 6.6e-16 51.9 In-house 91-160 (165) alignment 
Range on Protein: 224-293
Range on HMM: 91-160/165.0
FIDKVREVHGRVLLHCYAGKSRSATIAIGYIMKHLRLSLDEAYRFVKERRPTISPNLNFMGQLMQYEKDL
 |   .  . ..|.||  | ||||.. . ||||.  ||| .||  .| .   |||.. .. |||..|  |
iihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweval
subfamily_CDC14_pd Subfamily CDC14 224-279 2.2e-07 25.1 In-house 255-312 (328) alignment 
Range on Protein: 224-279
Range on HMM: 255-312/328.0
FIDKVREVHGRVLLHCYAGKSRSATIAIGYIMKHLRLSLDEAYRFVKERRPT--ISPN
|.. . ...| . .|| ||  |  |.   |.||| |..  ||  ...  ||   |.| 
fleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpq
subfamily_PTPDC1_pd Subfamily PTPDC1 232-276 4.2e-07 24.6 In-house 114-158 (182) alignment 
Range on Protein: 232-276
Range on HMM: 114-158/182.0
HGRVLLHCYAGKSRSATIAIGYIMKHLRLSLDEAYRFVKERRPTI
.|.| .||.||. |   .   |.. . ||. ..| ..|...||  
egkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpks