Gene Laforin in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily Laforin
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP014_AA protein Get Run
NvecP014_AA_148-312 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
CBM_20 Starch binding domain 3-97 1.4e-13 37.8 Pfam-A 2-84 (97) alignment 
Range on Protein: 3-97
Range on HMM: 2-84/97.0
ITVKFSVVTFIDRETTVSVLGSVPELGSWNQKNRIELTQSDSefrlgPGLEPsFWSKDVEMSFNGkselRFEYKFVSHK-NGNFIWEGegpCHNRK
..|.| | .      .| . |.|||||.|. .. |.|..|       .  .|  || .|... .     ..|||..  . .|. .||    ..||.
vsvtfkvnattqlgenvyivGnvpeLGnWdpakaiklsasee.....tssyp.lWsgtvslpagt....eieyKyikkdsdgsvtWes...genrs
0044763 (Phosphotyrosine protein) phosphatases II 140-296 1.1e-25 85.7 In-house 12-155 (178) alignment 
Range on Protein: 140-296
Range on HMM: 12-155/178.0
MCHVERQQIMHYCKIFENIWLGSCPRlRSHIMDLKSQGITAVISLQTASDIQKHCsgiyrynqnlpiTLKKLYKEEGISYIWLPMEDLSTESRIENLPQG
. ..|| . .....|.....|||.|   ...  || .|||....| .     ..             .... ..|.|| |...|..| .. . .| ... 
leglersdyinaseilpglylgslpp.addlellkelgithivnlteelelgflk............cdpywpeeagiqylhipipDhgvpdllehflef

VYLLHGLL-NNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPvAFI
| ... .| ..|..|.|||. |||||...|. .||..|..|| ..   . ..|| ...
vefieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivp
subfamily_Laforin_pd Subfamily Laforin 141-323 1.1e-119 390.0 In-house 1-183 (183) alignment 
Range on Protein: 141-323
Range on HMM: 1-183/183.0
CHVERQQIMHYCKIFENIWLGSCPRLRSHIMDLKSQGITAVISLQTASDIQKHCSGIYRYNQNLPITLKKLYKEEGISYIWLPMEDLSTESRIENLPQGV
..|||||||||.||.|||||||||||..|..||||.||||||||||.|||.|..|||||||.||||||||||||||..|||||.||||||||.|||||.|
fnverqqimhyskileniwlgscprlvehvidlksegitavislqtesdivknssgiyrynenlpitlkklykeeglayiwlptedlstesrvenlpqav

YLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPVAFIDGRALITAEKDFIQKFGQVKSRLTFIQ
||||.||..||.||||||.|||||||||||||.|||.||||||||....||||..||..|||.||||||||||||||||||||
yllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvvyideealiraekdfiqkfgqvksrltfiq
0041856 (Phosphotyrosine protein) phosphatases II 144-293 2.1e-21 71.8 In-house 16-152 (182) alignment 
Range on Protein: 144-293
Range on HMM: 16-152/182.0
ERqqimHYCKIFENIWLGSCPR-------------LRSHIMDLKSQGITAVISLQtasdiqkhcsgIY---RynqnlpitlkKLYKEEGISYIWLPMEDL
 |    ....| .|..|||.|              . ...  ||..|||....|             .              .|.. .|| |..||..| 
sr....dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt...........eelywp..........ellerlgiqylylpwpDh

STESrienLPQGVYLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPV
.. .    |.. . ...  |..|..|.|||..||||. ..|. .||..|..|| ..   . |.|| 
gvpd....ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpg
subfamily_DSP3_pd Subfamily DSP3 144-294 8.2e-11 35.8 In-house 4-141 (162) alignment 
Range on Protein: 144-294
Range on HMM: 4-141/162.0
ERQQIMHYCKIFENIWLGSCPRlRSHIMDLKSQGITAVISlqTASDiqkhcsgiyRYNQNLpiTLKKLYKEEGISYIWLPMEDLSTESRIENLPQGV-YL
|| .. ..  .......|      ..   ||  ||| |.   .|           |...    | .. ||. .| |. |...|  .    .   . . ..
erllskevdevypklyvgdeav.akdkskLkklGithvln..aaeg.........rfskvd..tgaefykdleikylGlevdDvpefdlskyFetaakfi

LHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPVA
 . | ..  .|.|||. || ||...|  .|| . . .| .   .. .|| . 
dealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkReil
subfamily_PTPMT1_pd Subfamily PTPMT1 145-296 5.6e-23 76.2 In-house 14-153 (171) alignment 
Range on Protein: 145-296
Range on HMM: 14-153/171.0
RQQIMHYCKIFENIWLGSCPrLRSHIMDL-KSQGITAVISLQTASDIQKHCSGIYRYNQNlpitlkklykeeGISYIWLPMEDLSTESRIENLPQGVYLL
...  .| .| ... ||  | .|| | .| ... . ||.||.   ... ..    .....            |. .. |.. |   .  .|.| .|| ..
askrnwydriDdtvilGalP.frslikeLiekenvkavvslneeyelkalansteewkkl............gveqlqlatvDfteapdleklekgvefi

HGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPVAFI
.   ..|.||||||..| |||...|  .||.  ..|. . .  . .||.   .
ekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirl
0051082 (Phosphotyrosine protein) phosphatases II 148-293 9.4e-20 66.2 In-house 5-134 (151) alignment 
Range on Protein: 148-293
Range on HMM: 5-134/151.0
IMHYCKIFENIWLGSCPrLRSHIMDLKSQGITAVISLQTASDIQkhcsgiyrynqnlpiTLKKLYKEEGISYIWLPMEDLSTESRIENLPQGVYLLHGLL
. ..  . ........| |  ..  ||..||.....| .   ..               .......|.|| ....|..| .. .  ..... . .|. ||
yinfsyvtgglyrsggp.ladflellkelgiktivnlrseeerg...............ycpeylpelgievlhipildwpdpglplsfdavleflelll

NN-GHRVYVHCNGGVGRSTAIVCGFLMYvLHWSLAKVQYNICSKRPV
.. .. |.|||..|.||. ..|. .||. |..||...   . .||| 
dkkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpg
0046846 (Phosphotyrosine protein) phosphatases II 149-295 6e-26 86.7 In-house 10-156 (176) alignment 
Range on Protein: 149-295
Range on HMM: 10-156/176.0
MHYCKIFENIWLGSCP---------RLRSHIMDLKSQGITAVISLQTASDIQKHCSGiyR--YNqnlpitlkklYKEEGISYIWLPMEDLSTESRiENLP
...  | .|..|||.|          | . .  ||..|||||..|..  .....     .              ....|| |..||..| .. .  | |.
ldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcp..nywpe..........leklgiqylhlpwpDhgvpdl.elll

QGVYLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYV-LHWSLAKVQYNICSKRP-VAF
. . ...  |..|..|.||| .|.||. ..|. .|..   ..|. .. . . ..||  |.
ellefirealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgav
0043147 (Phosphotyrosine protein) phosphatases II 149-295 8.2e-20 66.7 In-house 13-144 (172) alignment 
Range on Protein: 149-295
Range on HMM: 13-144/172.0
MHYCKIFENIWLGSCP---RLRSHIMDLKSQGITAVISLQTAsdiqkhcsgiyrynqnlpITLKKLYKEEGISYIWLPMEDLSTEsRIENLPQGVYLLHG
.... |  ... .  |    | ...  ||..|||....| .                    ....|....|| |..||..| ..   .| |.. . ... 
ldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..................lydpellerlgiqylylpwpDhgvp.llellleflefide

--LLNNGHRVYVHCNGGVGRSTAIVCGFLMYvLHWSLAKVQYNICSKRPVAF
  .|..|..|.||| .||||. ..|. .||. |..|| ..   . .||| |.
llalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgav
0036282 (Phosphotyrosine protein) phosphatases II 150-293 3.7e-22 74.3 In-house 11-151 (174) alignment 
Range on Protein: 150-293
Range on HMM: 11-151/174.0
HYCKIFENIWLGSCPRLrsHIMDLKSQGITAVISLQTASDIQKHCSGIYRYNqnlpitLKKLYKEEGISYIWLPMEDLSTESRIEnLPQGVYLLHGLLNN
.   | .....|..|    ..  ||..|||.|..| .    ...    | .       |.. ....|| |..||..| .. .  . | . | ...  |..
dlsyitprliagqgpla..fwemlkelgittvvmlleekelglykcinywpe......lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse

--GHRVYVHCNGGVGRSTAIVCGFLMYVLHW-SLAKVQYNICSKR---PV
  |. |.|||..||||. ..|. .||..... || .. . . ..|   | 
dpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpg
PTEN_1 150-297 1.6e-18 62.2 In-house 42-177 (196) alignment 
Range on Protein: 150-297
Range on HMM: 42-177/196.0
HycKIFENIWLGSCPRLRSHIMDLKSQGITAVISLQTASDIqkhcsgiyrynqNLPITLKKLYKEEGISYIWLPMEDLSTESRIENLPQGVYLLHGLL--
.  .|.|. ..|| . ....  .||..|||.|..|   ...            . .   .......|..|. .|.||  . |  | .   . . . ||  
q..eideglyrgslkdvaadldnlkedgitlvvnlseeeel............sgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsd

NNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPVAFID
.||. |.||| .|.|||  .|. .|||   ..  .    ...|||.. . 
pngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapn
0042113 (Phosphotyrosine protein) phosphatases II 150-295 2.8e-18 61.7 In-house 46-226 (245) alignment 
Range on Protein: 150-295
Range on HMM: 46-226/245.0
HYCKIFENIWLGSCPRLRsHIM----DLKSQGITAVISLQTASDIQK--------------------------HCSGIYRYNQNLPITlKKLYKEEGISY
. ..| ........|    ..      |...|||....| .  . ..                          |........ ..  . .. .. |.| |
dgyritpkfiatqgPlpe.tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnl.gddesrevihy

IWLPMEDLSTESRIENLPQGVYLLHGLLN--NGHRVYVHCNGGVGRSTAIVCGFLM-----YVLHWSLAKVQYNICSKRPVAF
 .||..| .. . .| | . . ...  |.  ....|.|||..||||. .... .||     . | .|| .. . . |.|| |.
hylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgav
0037934 (Phosphotyrosine protein) phosphatases II 150-294 1.6e-17 59.4 In-house 38-224 (243) alignment 
Range on Protein: 150-294
Range on HMM: 38-224/243.0
HYCKIFENIWLGSCP-------RLRSHIMDLKSQGITAVISLQTASDIQKH------------------------CSGIYRYNQNLPITLKKLYKEEGIS
 .............|       .| |..  |...|||....| .  . ..                         ....  ..  |  .  . .. ..| 
nliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvih

YIWLPMEDLSTESRIENLPQGVYLLHGL---------LNNGHRVYVHCNGGVGRSTAIVCGFLMYVL-HWSLAKVQYNICSKRPV-A
| .||. | .. . .|.| . .  ..           |..|..|.||| .||||. .... .||. | ...| ..   . ..||  |
yhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgka
0048076 (Phosphotyrosine protein) phosphatases II 151-296 2e-26 87.8 In-house 4-127 (145) alignment 
Range on Protein: 151-296
Range on HMM: 4-127/145.0
YCKIFENIWLGSCPRLRShIMDLKSQGITAVISLqtasdiqkhcsgiyrynqnlpITLKKLYKEEGISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNG
...|.....|||.|  .. .  ||. |||.|..|                      . ..|....|| |..||..| .. . .| |.. . ... .|..|
pseilpglylgslptald.lellkdlgittvlnl.....................tselellerlgiqylylpwpDhgvpdllellleflefieealkeg

HRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPVAFI
..|.|||. ||||....|. .||. |..|| ..   . |.|| |..
gpvlVHCsaGvgRtgtlvaaylmlllgvsleealelvrsqrpgavp
0048179 (Phosphotyrosine protein) phosphatases II 151-296 1.3e-25 85.2 In-house 4-129 (144) alignment 
Range on Protein: 151-296
Range on HMM: 4-129/144.0
YCKIFENIWLGSCPrLRSHIMDLKSQGITAVISLQTASDIQKHCSGiyrynqnlpitlkklykeeGISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNG
...|.....|||.|   ...  ||..|||.||.|..  . .                        || |..||..| .. . .| |.. . ... .|..|
pseilpglylgslp.taldlellkklgittvinlteeyepeflere...................giqylhlpwpDhgvpdllellleflefieealeeg

HRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPVAFI
..|.|||..||||....|. .||..|..|| .. . . |.|| |..
gpvlVHCsaGvgRtgtlvaaylmkklglsleealalvrsrrpgavp
0045098 (Phosphotyrosine protein) phosphatases II 151-295 3e-16 55.1 In-house 22-255 (278) alignment 
Range on Protein: 151-295
Range on HMM: 22-255/278.0
YCKIFENIWLGSCPR----------------------------------------LRSHIMDLKSQGITAVISLQTASDIQKHCSGIYRYNQN-------
 ..|.....||. ..                                        . ...  |...|||....| .  . ..     | ....       
pseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdf

-----------------L----PITLKKLYKEEGISYIWL-PMEDLSTESRI--ENLPQGVYLLHGLLN--------------NGHRVYVHCNGGVGRST
                 |      . .. ... |. .... |..| .. |      . . .  ..  |.              .|..|.|||. ||||. 
tvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtG

AIVCGFLMYVL---HWSLAKVQYNICSKRPV-AF
..|. .||. |   ...| ..   . |.||  |.
tlvaaylmlelleggvdlleavkelrsqRpglav
0049772 (Phosphotyrosine protein) phosphatases II 153-322 1.3e-23 79.6 In-house 150-283 (314) alignment 
Range on Protein: 153-322
Range on HMM: 150-283/314.0
KIFENIwlgscprlrshimdlksqgitaviSLQTASDIQKHCsgiyrynqnLPITLKKLYKEEGISYIWLPMEDlSTESRIENLPQGVYLLHGLlNNGHR
.. .|                         .. ||.|.. ..           .. ..|....|| |...|..|  ..  .| ... . ... . ..|..
ildgng........................neptaadlellk.........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggp

VYVHCNGGVGRST-AIVCGFLMYVLHWSLAKVQYNICSKRPvAFIDGrALITAEKDFIQKFGQVKSRLTFI
|.|||..|.||.. ..|...||. |..||...   . .||| . .    .|   ....... ... .| |.
vlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnp.gfieqleqyefilealleylkfl
PTPc_motif_SM00404 153-291 2.8e-17 57.9 In-house 4-121 (140) alignment 
Range on Protein: 153-291
Range on HMM: 4-121/140.0
KIFENIWLGSCPRLRsHIMDLKSQGITAVISLQTASDIQkhcsgiyrynqnlpitlkklYKEEGISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHR
.| ....|||...   .   ||. |||.||....  ...                    ....|. ....|..|  ..   . |.. .  ..   ..|..
rilphlylgskskaq.npallkklgithvinvteevslt....................kensgfqilqiplddnekdklskyldkvldfienaekkggk

VYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKR
|.|||  || || .... .||.  ..|||.. . . ..|
vlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerR
subfamily_DSP12_pd Subfamily DSP12 153-292 2.7e-12 41.3 In-house 4-124 (155) alignment 
Range on Protein: 153-292
Range on HMM: 4-124/155.0
KIFENIWLGSCPRLRSHiMDLKSQGITAVISLQTASDiqkhcsgiyrynqnlpitLKKLYKEEGISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHR
.| ....||. . . ..   ||. .||.|.|... .                    .   |.  .|.  ... |  .|  ...|.. |  ..  |...  
rilpglylggleavqee.ellkelkithvlsvikeel..................pehklkkgkvstkfiqilDepeediLshldeavdFieealeeega

VYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRP
|.|||. || || .||  .||.  ..|| |    . .|.|
vlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkp
subfamily_DSP15_pd Subfamily DSP15 153-294 6.5e-10 33.3 In-house 4-122 (151) alignment 
Range on Protein: 153-294
Range on HMM: 4-122/151.0
KIFENIWLGSCPRLRSHiMDLKSQGITAVISLQTasdiqkhcsgiyrynqnlpiTLKKLYKEegISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHR
|. ....||     . .   || . || ..|..                       ||| |.  |.|  ....| .     . . . | ..|    ... 
kvlpglylgnfrdskde.elLkeknithilsvhd....................nakkllkd..ieYkciaasDtpsaklskffkesvefihkcRlkeen

VYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPVA
|.|||  || ||. .|  .|| |.. .  ..   |  .| ||
vlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsva
subfamily_STYX_pd Subfamily STYX 154-276 5.1e-10 32.7 In-house 15-122 (166) alignment 
Range on Protein: 154-276
Range on HMM: 15-122/166.0
IFENIWLGSC-PRLRSHIMDLKSQGITAVISLQtasdiqkhcsgiyrynQNLPITLKKLYKEEGISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHR
|.  ..||     ..|..  ||..||| .. ..                ||.  .| |   .. . |. | . | ..|  |  ||.   .. . |..| .
ilpglflgpysaamksklevlkkhgithivcir................qnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggk

VYVHCNGGVGRSTAIVCGFLMYVL
| || | |. ||.|.| ...|   
vlvhgnagisrsaalviayimety
DSPc Dual specificity phosphatase, catalytic domain 158-291 3.9e-16 54.1 Pfam-A 1-114 (133) alignment 
Range on Protein: 158-291
Range on HMM: 1-114/133.0
IWLGSCPRLRshIMDLKSQGITAVISLQTASDIQkhcsgiyrynqnlpitlkKLYKEEGISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHRVYVHC
..|||...       |. .|||.||....  . .                  ...|.. | |...|.|| ...   . |.. |  .. . ..|..|.|||
lylgskstas..lalleklgitlvinvtkevpnn..................naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHC

NGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKR
. |. || .... .||.  ..|| .  . . ..|
qaGisRSatliiaYlmktknlslneAyefvkerr
DSPc Dual specificity phosphatase, catalytic domain 158-291 3.9e-16 54.1 In-house 1-114 (133) alignment 
Range on Protein: 158-291
Range on HMM: 1-114/133.0
IWLGSCPRLRshIMDLKSQGITAVISLQTASDIQkhcsgiyrynqnlpitlkKLYKEEGISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHRVYVHC
..|||...       |. .|||.||....  . .                  ...|.. | |...|.|| ...   . |.. |  .. . ..|..|.|||
lylgskstas..lalleklgitlvinvtkevpnn..................naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHC

NGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKR
. |. || .... .||.  ..|| .  . . ..|
qaGisRSatliiaYlmktknlslneAyefvkerr
subfamily_CDKN3_pd Subfamily CDKN3 166-275 3.1e-09 30.7 In-house 59-157 (202) alignment 
Range on Protein: 166-275
Range on HMM: 59-157/202.0
LRSHIMDLKSQGITAVISLQTASDIQKhcsgiYRYNQnlpitLKKLYKEEGISYIWLPMEDLSTESrIENLPQGVYLLHGLLNNGHRVYVHCNGGVGRST
... | .|||||.  |. | |  ...|     || ..     | .||.. |..    |. |  . . | .  . .  |.  |.....  ||| ||.|||.
vekdieelksqgvedvfvlctrgelsk.....yrvrr.....lldlyqqaglivhhypiadglvpd.iasclkileelrinlkayrktlvhcygglgrss

AIVCGFLMYV
 ..  .|.|.
lviaclllyl
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 167-275 6e-07 20.8 Pfam-A 61-158 (168) alignment 
Range on Protein: 167-275
Range on HMM: 61-158/168.0
RSHIMDLKSQGITAVISLQTASDIQKhcsgiYRYnqnlPiTLKKLYKEEGISYIWLPMEDLSTEsRIENLPQGVYLLHGLLNNGHRVYVHCNGGVGRSTA
.    .||| ||  |. . |  .. |     ||     |  |  ||.. ||     |. |  |   |    . .  |   |.| ..  .|| ||.|||  
qkdteelksygiqdvfvfctrgelsk.....yrv....p.nlldlyqqygivthhhpiadggtp.diascleimeelatclknyrktlihcygglgrscl

IVCGFLMYV
. . .|.|.
vaaclllyl
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 167-275 6e-07 20.8 In-house 61-158 (168) alignment 
Range on Protein: 167-275
Range on HMM: 61-158/168.0
RSHIMDLKSQGITAVISLQTASDIQKhcsgiYRYnqnlPiTLKKLYKEEGISYIWLPMEDLSTEsRIENLPQGVYLLHGLLNNGHRVYVHCNGGVGRSTA
.    .||| ||  |. . |  .. |     ||     |  |  ||.. ||     |. |  |   |    . .  |   |.| ..  .|| ||.|||  
qkdteelksygiqdvfvfctrgelsk.....yrv....p.nlldlyqqygivthhhpiadggtp.diascleimeelatclknyrktlihcygglgrscl

IVCGFLMYV
. . .|.|.
vaaclllyl
0049260 (Phosphotyrosine protein) phosphatases II 169-295 8.4e-18 60.0 In-house 25-133 (152) alignment 
Range on Protein: 169-295
Range on HMM: 25-133/152.0
HIMDLKSQGITAVISLQTASDIQKHCSGIYRynqnlpitlkklykeegiSYIWLPMEDLSTESRIENLPQGVYLLHG-LLNNGHRVYVHCNGGVGRSTAI
..  ||..|||....| . ... | .   |                    |..||..| .. . .. |.. . ...  .|..|..|.||| .||||. ..
fwrmlkelgittivmltellelgklkceqyi..................qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtl

VCGFLMYvLHWSLAKVQYNICSKRPVAF
|. .||. |..|| ..   . .|||.|.
vaaylml.lgvsleeavalvrekRpgav
0045450 (Phosphotyrosine protein) phosphatases II 171-295 4e-15 51.8 In-house 125-287 (307) alignment 
Range on Protein: 171-295
Range on HMM: 125-287/307.0
MDLKSQGITAVISLQTASDIQKH-------CSGIYRYNQNLPITLKKLYKEEGISYIWLPMEDL-----------------STESRIENLPQGVYLLHGL
  |. ||.|....| .  .  .         .| . .  |. .||.. ....|. . .|...||                    .  ... . . ... .
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

LN------NGHRVYVHCNGGVGRSTAIVCGFLMYVLH--------WSLAKVQYNICSKRPVAF
..      .|..|.|||..||||. .... .||....        ..| ..   . ..|| |.
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgav
0040439 (Phosphotyrosine protein) phosphatases II 171-295 1.8e-13 46.2 In-house 72-229 (249) alignment 
Range on Protein: 171-295
Range on HMM: 72-229/249.0
MDLKSQGITAVISLQTASDIQK-HCSGIY-------------------RYNQNL--PITLKKLYKEEGISYIWLPMEDLSTESRIENLPQGVYLLHGLLN
  |. .|||....| .    .. .|  ..                    ..      ..|..||. | . . .... |.   .  ..... . ... ...
rmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrk

------NGHRVYVHCNGGVGRSTAIVCGFLM-----YVLHWSLAKVQYNICSKRPVAF
      .|..|.|||..||||. .... .||     . |...|  .   . |.|| |.
aleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgav
subfamily_PTPDC1_pd Subfamily PTPDC1 171-310 2e-12 41.9 In-house 40-173 (182) alignment 
Range on Protein: 171-310
Range on HMM: 40-173/182.0
MDLKSQGITAVISLQTASDiQKHCsGIYRYNQNLPITLKKLyKEEGISYIWLPMEDLSTESrIENLPQGVYLLHGLLNNGhRVYVHCNGGVGRSTAIVCG
 ..|..||.||| ||.. .   .| |    ..     |..| .|.|| .  ....| .. | .|.. . | ...  |..| .| |||  | ||   ... 
dkfkesgikavinLqekge.hasC.GagleesGfsYdleal.meqgiyvynfgwkDygvas.leriLdivkvvafalqeg.kvavhChaGlGrtGvliac

FLMYVLHWSLAKVQYNICSKRPVAfIDGRALITAEKDFIQ
.|.|. . . .|    . |||| . |  |  .   |.| .
ylvyakrltaekaiklvrskrpks.iqtreqvelvkefal
0043336 (Phosphotyrosine protein) phosphatases II 171-295 2.3e-12 42.4 In-house 106-260 (278) alignment 
Range on Protein: 171-295
Range on HMM: 106-260/278.0
MDLKSQGITAVISLQTASDIQK-------------------HCSGIYRYNQNLPITL-----KKLYKEEGISYIWLPMEDLSTESRIENLPQGVYLLHGL
  .. .|.| ...| .  . ..                   .. ... ..    .||     .. .. ..  | .|.. | .. . .. | . .  ..  
rmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrea

LN-NGHRVYVHCNGGVGRSTAIVCGFLM-----YVLHWSLAKVQYNICSKRPVAF
|. ... |.|||..||||. .... .|.     . ....| ..   . ..|| |.
ledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgav
0039614 (Phosphotyrosine protein) phosphatases II 172-295 2.8e-15 52.0 In-house 120-272 (297) alignment 
Range on Protein: 172-295
Range on HMM: 120-272/297.0
DLKSQGITAVISLQTASDIQKHCSGIYR----YNQNLPITLKKLYKEEGIS-----------------YIWLPMEDLSTESRIENLPQGVYLLHGLLN--
 .. ||.|....| .  . ...|   .     .  .. .||.| ....|.                  . .... | .. . .| | . . |..  |.  
mvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael

-NGHRVYVHCNGGVGRSTAIVCGFLM-----YVLHWSLAKVQYNICSKRPVAF
 .|..|.|||..||||. .... .||     .  .... ..   . ..|| |.
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgav
0051429 (Phosphotyrosine protein) phosphatases II 172-297 4.4e-14 48.3 In-house 40-210 (272) alignment 
Range on Protein: 172-297
Range on HMM: 40-210/272.0
DLKSQGITAVISLQTASDIQKHCSGIYRynqnlpitlkklykeEGISYIWLPMEDLSTESRIENL-----------------------------------
 ||..||.....| . . ....    |                .|| |..||..| |...   .                                    
rlkelgiktivdLrseeErgrlkcdryw...............pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmh

-------------PQGVYLLHGLLNnGHRVYVHCNGGVGRSTAIVCGFLMYvLHWS--------------LAKVQYNICSKRPVAFID
              . . ||. ||. |..|.|||..|..|.  .|. .|.. | .|              |...   . ..|| |. .
lhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqt
0040438 (Phosphotyrosine protein) phosphatases II 173-296 1.8e-14 49.2 In-house 106-260 (317) alignment 
Range on Protein: 173-296
Range on HMM: 106-260/317.0
LKSQGITAVISLQTASDIQK--------HcsGIYRYNQNLPITLKKLYKEEGISYIWLPMEDL----------------STESRIENLPQGVYLLHGLLN
.. ||.| ...| .  . ..        .  | . .  .. .||.. ....|| . .|..|||                   .  ... . . .|. . .
vweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

N----GHRVYVHCNGGVGRSTAIVCGFLM-----YVLHWSLAKVQYNICSKRPVAFI
.    |. | |||..||||. .... .||     .  .... .. . . ..|| |. 
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavq
0047943 (Phosphotyrosine protein) phosphatases II 175-296 2.4e-10 35.8 In-house 99-256 (273) alignment 
Range on Protein: 175-296
Range on HMM: 99-256/273.0
SQGITAVISLQTASDIQKH-CSGI--------YRYNQNLPITLKKLYKEEGISYIWLP-------------------MEDLSTESRIENLPQGVYLLHGL
 |... ...| .  . ..  |           . .  .. .||.. ......    |                      | .. . .| | . . |..  
eqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrka

LN---NGHRVYVHCNGGVGRSTAIVCGFLM-----YVLHWSLAKVQYNICSKRPVAFI
|.   ... |.|||..||||. .... .|.     .   ... .. . ..|.|| ...
lealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvq
0036941 (Phosphotyrosine protein) phosphatases II 175-295 1e-09 33.6 In-house 100-260 (297) alignment 
Range on Protein: 175-295
Range on HMM: 100-260/297.0
SQGITAVISLQTASDIQK--------HCSGIYRYNQNLPITLKKLYK--EEGISYIWLPMED---------------------LST-ESRIENLPQGVYL
 |..| ...| .  . ..        .  | . .  .. .||.. ..  .... . .| ..|                     . .  . . .. . |  
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

LHGLLNNGHRVYVHCNGGVGRSTAIVCGFLM--------YVLHWSLAKVQYNICSKRPVAF
 . ||..|..|.|||..||||| .... .||        .   ... ..   . ..|| |.
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgav
0046845 (Phosphotyrosine protein) phosphatases II 177-295 7.8e-09 30.8 In-house 101-257 (284) alignment 
Range on Protein: 177-295
Range on HMM: 101-257/284.0
GITAVISLQTASDIQKHCSGIYRYNQN-------LPITLKKLYKEEGISYI--------------------WLPMEDLSTESRIENLPQGVYLLHGLLNN
... ...| .  . ..     |. . .       . .||.. ...... ..                    ...  | .. . .|.| . . |.. ||.|
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

---GHRVYVHCNGGVGRSTAIVCGFLMYVL--------HWSLAKVQYNICSKRPVAF
   |. . ||| .||||. ....  |.. .        .... .. . ....|| ..
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmv
0038934 (Phosphotyrosine protein) phosphatases II 191-295 2.8e-16 55.2 In-house 54-160 (194) alignment 
Range on Protein: 191-295
Range on HMM: 54-160/194.0
QKHCSGIYRYNQNLPITLKKLYKEEGISYIWLPMEDLSTESRIENLPQGVYLLHGLLNN--GHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNIC
....  ..... . .   ...... || |. ||..|  |   .|.| . . |..  ||.  |. |.||| .|.||.  .|. .|.|.|..|. .  . . 
nvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfr

SKRPVAF
.||| |.
ekRpgai
subfamily_DSP6_pd Subfamily DSP6 201-290 3.6e-10 33.6 In-house 43-132 (158) alignment 
Range on Protein: 201-290
Range on HMM: 43-132/158.0
NQNLPITLKKLYKEEG-ISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVqYNICSK
  |.   | . ..|.| . |  .|.||  ..   . .|. . ..    ..   | |||  |. || ...  .||  |. || .  |..  |
vlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlaylmkklalslnda.ydlvkk
subfamily_Slingshot_pd Subfamily Slingshot 202-293 3.5e-07 23.8 In-house 49-139 (169) alignment 
Range on Protein: 202-293
Range on HMM: 49-139/169.0
QNLPITLKKLYKeEGISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPV
 |.   ... .. | ..|. . . | ...  ...  .    ..   ..| .| |||  || ||...|  . |   ..|| .    . ..| |
lnvtkeidnffp.ekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerrsv
subfamily_DSP10_pd Subfamily DSP10 203-293 5.5e-10 33.3 In-house 45-135 (159) alignment 
Range on Protein: 203-293
Range on HMM: 45-135/159.0
NLPITLKKLYKEEGISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPV
|.  .. . ..||...|  .|..| |..   ..  . .  ..   ..|.|| |||. |. ||...| ..||. |. || .    . .|||.
nvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpi
0051299 (Phosphotyrosine protein) phosphatases II 204-295 2e-08 29.5 In-house 149-269 (288) alignment 
Range on Protein: 204-295
Range on HMM: 149-269/288.0
LPITLKKLYKEEGISYIWLPME-----------------------DLSTESRIENLPQGVYLLHGL-LNNGHRVYVHCNGGVGRSTAIVCGFLM-----Y
. .||.. ...... . .| ..                       | .. . .| | . . |..    ..|. |.|||. ||||. .... .|.     .
itvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlek

VLHWSLAKVQYNICSKRPVAF
  .... ..   ....|| ..
eggvdvleavkrlreqRpgmv
subfamily_DSP19_pd Subfamily DSP19 207-293 1e-11 39.4 In-house 47-132 (152) alignment 
Range on Protein: 207-293
Range on HMM: 47-132/152.0
TLKKLYKEEgISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPV
 ..... .. . |  ... ||. .. .. |.. .  ..  ...  .|.|||| || ||...| ..||   . || .    . ..|| 
gvpnvfpkd.ftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpc
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 210-293 1.2e-07 25.3 In-house 46-129 (148) alignment 
Range on Protein: 210-293
Range on HMM: 46-129/148.0
KLYKEEGISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPV
. . . || |. ....|   |      .. .  ..   ..|.|| ||.. || ||.|..  .|.   . || .    . |||. 
naldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrvslkealalvkskrry
subfamily_DSP14_pd Subfamily DSP14 213-293 6.4e-09 29.9 In-house 46-126 (157) alignment 
Range on Protein: 213-293
Range on HMM: 46-126/157.0
KEEGISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPV
| ..|... .|.|| ....  . . . .  .. . ..|... |||  || || ...  .||   . ||..    . |.||.
klkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRpi
subfamily_DSP1_pd Subfamily DSP1 214-293 1.5e-09 32.1 In-house 60-138 (163) alignment 
Range on Protein: 214-293
Range on HMM: 60-138/163.0
EeGISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPV
.   .| .|..|| ...   . . . .  ..   ... .|..||. |. ||....  .||   ..|| .    . ..|..
d.lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsi
subfamily_MKPLT_pd Subfamily MKPLT 215-294 1.1e-08 28.8 In-house 64-143 (164) alignment 
Range on Protein: 215-294
Range on HMM: 64-143/164.0
EGISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPVA
. . |  . .|| |.|  .. | .   .|   ...| ||.|||. |. ||...   ||.    | | .    .  .| ..
ksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsiv
subfamily_MKPLV_pd Subfamily MKPLV 215-294 1.1e-08 28.8 In-house 64-143 (164) alignment 
Range on Protein: 215-294
Range on HMM: 64-143/164.0
EGISYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPVA
. . |  . .|| |.|  .. | .   .|   ...| ||.|||. |. ||...   ||.    | | .    .  .| ..
ksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsiv
subfamily_DSP8_pd Subfamily DSP8 218-292 8e-07 22.7 In-house 61-135 (159) alignment 
Range on Protein: 218-292
Range on HMM: 61-135/159.0
SYIWLPMEDLSTESRIENLPQGVYLLHGLLNNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRP
 .. .|..|  .|  .. ... |  .    ..  || ||.  |  ||.... ...|  |. || .    . .|||
kflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekrp
0050432 (Phosphotyrosine protein) phosphatases II 219-296 9e-09 30.5 In-house 202-283 (308) alignment 
Range on Protein: 219-296
Range on HMM: 202-283/308.0
YIWLPMEDLSTESRIENLPQGVYLLHGLLnNGHRVYVHCNGGVGRSTAIVCGFLM-----YVLHWSLAKVQYNICSKRPVAFI
. ..  .| .. . .| | . . |..  | .|. ..|||. ||||. ....  |.     .  .... .. . . ..|| ...
fhytnWpdhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvq
0048567 (Phosphotyrosine protein) phosphatases II 242-292 1.2e-06 23.0 In-house 62-119 (157) alignment 
Range on Protein: 242-292
Range on HMM: 62-119/157.0
LLHGLLN----NGHRVYVHCNGGV---GRSTAIVCGFLMYVLHWSLAKVQYNICSKRP
.|. .|.    .|....|||  |    ||.  ... .|...|... ...   .   ||
klnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrp
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 248-296 4.1e-06 20.0 In-house 78-126 (145) alignment 
Range on Protein: 248-296
Range on HMM: 78-126/145.0
NNGHRVYVHCNGGVGRSTAIVCGFLMYVLHWSLAKVQYNICSKRPVAFI
..|  |.|||  || || ..   |||     .|..   .. |.|  |. 
eegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllayp