Gene PRL in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PRL
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP016_AA protein Get Run
NvecP016_AA_0-138 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PRL_pd Subfamily PRL 1-140 1.2e-75 246.6 In-house 10-149 (151) alignment 
Range on Protein: 1-140
Range on HMM: 10-149/151.0
MKFLITDRPTNSTLPQYIQDLKKYDAHTVVRVCEPTYNTETLSKEGIIVLDWPFDDGAAPPKQLVEDWLKLLKGKFKERPGSCVAVHCVAGLGRAPVLVA
|.||||||||..||...|..|||....||||||||||.||.|.|||| |||..|||||.||...||.||.||| ||||.|.|.|||||||||||||||||
mrflitdrPtdatlekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlva

LALIESGMKYEDAVEFIRRKRRGAINAKQLSYLERYKPTK
|||||.||||||||||||.|||||||.|||..||.||..|
lalieaGmkyedavefirekrrgainskqlkflekykakk
0040438 (Phosphotyrosine protein) phosphatases II 1-136 1.4e-24 82.4 In-house 86-271 (317) alignment 
Range on Protein: 1-136
Range on HMM: 86-271/317.0
MKFLITDRPTNSTLPQYIQDLKKYDAHTVVRVCEPTYN------------------------TETLSKEGIIVLDWPF-------------------DDG
.||..|  |...|.  ... ..... ...|...|....                        ...  ..||...  ..                   .|.
rkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdh

AAP-PKQLVEDWLKLLKGKFKeRPGSCVAVHCVAGLGRAPVLVALALI------ESGMKYEDAVEFIRRKRRGAI-NAKQLSYLERY
 .|   .|. |.|.... ... .||..|.|||.||.||. ...|. |.      | |. .|.||...|..|.||. .  |. .| ..
gvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
0038934 (Phosphotyrosine protein) phosphatases II 2-135 3.9e-37 123.2 In-house 19-168 (194) alignment 
Range on Protein: 2-135
Range on HMM: 19-168/194.0
KFLITDRPTNSTLPQYIQDLKKYDAHTVVRVC----------------EPTYNTETLSKEGIIVLDWPFDD-GAAPPKQLVEDWLKLLKGKFKERPGSCV
.|.....|....| .||..|....  ..||..                |..|..| . | || .|..|| | |..|. ... ..|.|.. ...| || .|
rfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvv

AVHCVAGLGRAPVLVALALIE-SGMKYEDAVEFIRRKRRGAINakQLSYLER
||||.|||||...||| .||.  ||..|.|....|.||.|||.  . .||| 
aVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaip..nqdylea
0043147 (Phosphotyrosine protein) phosphatases II 2-136 1.3e-35 118.0 In-house 21-156 (172) alignment 
Range on Protein: 2-136
Range on HMM: 21-156/172.0
KFLITDRPTNSTLPQYIQDLKKYDAHTVVRVCEPTYNTETLSKEGIIVLDWPFDDGAAPPKQLVEDWLKLLKGKFKERPGSCVAVHCVAGLGRAPVLVAL
.|..|  |...||..... ||... ...|...| .|..| |...|| .| .|..|. .|. .|....|.... .. ..|| .|.|||.||.||...|||.
rfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaa

ALIESGMKYEDAVEFIRRKRRGAI-NAKQLSYLERY
 |.. |...|.||...|.||.||. |  |. .|  .
ylmllglsleeavalvrekRpgavqnpsqyrflyyf
0049260 (Phosphotyrosine protein) phosphatases II 2-133 1.3e-33 111.2 In-house 10-142 (152) alignment 
Range on Protein: 2-133
Range on HMM: 10-142/152.0
KFLITDRPTNSTLPQYIQDLKKYDAHTVVRVCEPTYNTETLSKEGIIVLDWPFDDGAAPPKQLVEDWLKLLKGKFKERPGSCVAVHCVAGLGRAPVLVAL
.|..|  |.. ||..... ||.....|.|...|......   ...| .| .|..|. .|.   . ..| |.  |.....| .|.|||.||.||...|||.
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaa

ALIESGMKYEDAVEFIRRKRRGAINA-KQLSYL
 |.. |...|.||...|.|| ||.    || .|
ylmllgvsleeavalvrekRpgavpnpgqlrfl
0040439 (Phosphotyrosine protein) phosphatases II 2-136 8.7e-30 99.5 In-house 55-241 (249) alignment 
Range on Protein: 2-136
Range on HMM: 55-241/249.0
KFLITDRPTNSTLPQYIQDLKKYDAHTVVRVCEPT---------------------------------------------YNTETLSKEGIIVLDWPfDD
.|..|. |...|.. ... |.... ...|......                                             |. |..   .| ..||| |.
rfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp.dh

GAAPPKQLVEDWLKLLKGKFKER-PGSCVAVHCVAGLGRAPVLVALALI------ESGMKYEDAVEFIRRKRRGAI-NAKQLSYLERY
|. |  . . |......  ..|  .|..|.||| ||.||.....|. |.      | |. .|.||...|..|.||. |  |. .| ..
gvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea
0045098 (Phosphotyrosine protein) phosphatases II 2-136 3.4e-29 97.5 In-house 65-267 (278) alignment 
Range on Protein: 2-136
Range on HMM: 65-267/278.0
KFLITDRPTNSTLPQYIQDLKKYDAHTVVRVCEPTYNT----------------------------------------------ETLSKEGIIVLDW-PF
||..|. |..||. .... |.... ...|...| ....                                              |.| . |. .|.. |.
kfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpw

DDGAAPPKQLVEDWLKLLKGKFKER---------------PGSCVAVHCVAGLGRAPVLVALALIES----GMKYEDAVEFIRRKRRG-AI-NAKQLSYL
.|. .|.  ..  .|.||.   . .               .| .|.||| ||.||. .|||. |. .    |. ...||...|..|.| |. |  |. .|
pdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrfl

ERY
...
yef
0041856 (Phosphotyrosine protein) phosphatases II 2-138 1.2e-28 95.3 In-house 35-167 (182) alignment 
Range on Protein: 2-138
Range on HMM: 35-167/182.0
KFLITDRPTNSTLPQYIQDLKKYDAHTVVRVCEPTYNTETLSKEGIIVLDWPFDDGAAPPkqlVEDWLKLLKGKFKerPGSCVAVHCVAGLGRAPVLVAL
.|..| .|..||...... ||... .|.|...|. |. | | ..|| .|..|..|. .|.   ....|....   .  .| .|.||| ||.||...|||.
rfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd...ldelldfieevle..eggpvlVHCsaGvgRtgtlvaa

ALIE-SGMKYEDAVEFIRRKRRGAINAKQLSYLERYKP
 |..  |. .|.||...|..| |..   .  ...... 
ylmkklgvsleeavklvrsrRpgmvitpnqyfflqlal
0036282 (Phosphotyrosine protein) phosphatases II 2-136 3.6e-28 93.8 In-house 18-165 (174) alignment 
Range on Protein: 2-136
Range on HMM: 18-165/174.0
KFLITDRPTNstlpqYIQDLKKYDAHTVVRVCEPTYNT------------ETLSKEGIIVLDWPFDDGAAPPKQLVEDWLKLLKGKFKERPGSCVAVHCV
...... |..     ... ||... .|||...|. ..             | |...|| .|..|..|. .|. . .....|...  ..| || .|.||| 
rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCs

AGLGRAPVLVALALIESGM--KYEDAVEFIRRKR----RGAINAKQLSYLERY
||.||...|||. |.. |.  ...||....|..|    .. ..  |. .|  .
aGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyf
0045450 (Phosphotyrosine protein) phosphatases II 2-136 6.9e-28 93.7 In-house 108-299 (307) alignment 
Range on Protein: 2-136
Range on HMM: 108-299/307.0
KFLITDRPTNSTLPQYIQDLKKYDAHTVVRVCEPTYNTET------------------------------------------LSKEGIIVLDWPF---DD
||..|. |...|.  ... |.... ...|...|.....                                             ..|...|  ...    |
kfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpd

GAAPP-KQLVEDWLKLLKGKFKER-PGSCVAVHCVAGLGRAPVLVALALIESG---------MKYEDAVEFIRRKRRGAI-NAKQLSYLERY
. .||  . . |......  ..|  .|..|.||| ||.||.....|. |. ..         . ...||...|..| ||. |  |. .| ..
hgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea
0042113 (Phosphotyrosine protein) phosphatases II 2-136 1e-27 92.5 In-house 53-238 (245) alignment 
Range on Protein: 2-136
Range on HMM: 53-238/245.0
KFLITDRPTNSTLPQYIQDLKKYDAHTVVRVCEPTYN-------------------------------------------TETLSKEGIIVLDWPFDDGA
||..|. |...|.. ... |.... .|.|...|....                                            .  |.|.| ..  |..|. 
kfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhg

APP-KQLVEDWLKLLKGKFKERPGSCVAVHCVAGLGRAPVLVALALI------ESGMKYEDAVEFIRRKRRGAI-NAKQLSYLERY
.|.  .|..|.|....   .| ..  |.||| ||.||. ...|. |.      | |.  |.||...|..|.||. .  |. .| ..
vpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
0039614 (Phosphotyrosine protein) phosphatases II 2-136 2.2e-27 91.7 In-house 102-284 (297) alignment 
Range on Protein: 2-136
Range on HMM: 102-284/297.0
KFLITDRPTNSTLPQYIQDLKKYDAHTVVRVCEPTYN----------------------TETLSKEGII-------------------VLDWPfDDGAAP
||..|  |...|.  ... ..... ...|........                      ...  ..|..                   ...|| |.|. |
kfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwp.dhgvpp

PKQLVEDWLKLLKGKFKER-PGSCVAVHCVAGLGRAPVLVALALI------ESGMKYEDAVEFIRRKRRGAI-NAKQLSYLERY
  .|. ..|.|..  ..|  .| .|.|||.||.||. ...|. |.      | |. ...||...|..|.||. .  |. .| ..
slellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyda
0043336 (Phosphotyrosine protein) phosphatases II 2-135 3.5e-26 87.7 In-house 89-271 (278) alignment 
Range on Protein: 2-135
Range on HMM: 89-271/278.0
KFLITDRPTNSTLPQYIQDLKKYDAHTVVRVCEPT--------------------------------------------YNTETLSKEGIIVLDWPfDDG
||..|  |...|.  ... ..... .|.|...|..                                            .. |..   ..  |.|| |.|
kfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp.dhg

AAPPKQLVEDWLKLLKGKFKeRPGSCVAVHCVAGLGRAPVLVALALI------ESGMKYEDAVEFIRRKRRGAI-NAKQLSYLER
. .. .|. |.|| .. ...  ....|.|||.||.||. ...|| |.      | |. .|.||...|..| ||. .  |. .| .
vpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflye
0037934 (Phosphotyrosine protein) phosphatases II 2-136 4.8e-25 84.0 In-house 45-237 (243) alignment 
Range on Protein: 2-136
Range on HMM: 45-237/243.0
KFLITDRPTNSTLPQ----YIQDLKKYDAHTVVRVCEPT------------------------------------------YNTETLSKEGIIVLDWPFD
.. .|. |...|. .    ... |.... ...| ..|..                                          .... |....| .. .|. 
rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp

DGAAPP-KQLVEDWLKLLKGKFKE-------RPGSCVAVHCVAGLGRAPVLVALALIES--GMKYEDAVEFIRRKRRG-AI-NAKQLSYLERY
|. .|.  . . |.|. ..   .|        .|. |.|||.||.||. .|.|. |. .  |. .|.||...|..| | |. .  |. .| ..
dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea
0047943 (Phosphotyrosine protein) phosphatases II 2-129 6.6e-23 77.0 In-house 78-260 (273) alignment 
Range on Protein: 2-129
Range on HMM: 78-260/273.0
KFLITDRPTNSTLPQYIQDLKKYDAHTVVRVCEPTYNTE--------------TLSKEGI----------------------------------IVLDWP
||..|. |...|.  ... .........|...|....                .|  . .                                   ...||
kfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwp

fDDGAAPPKQLVEDWLKLLKGKFKER-PGSCVAVHCVAGLGRAPVLVALALI------ESGMKYEDAVEFIRRKRRGAIN-AKQ
 |.|. |  . . ....|.. ....   .. |.|||.||.||. ...|| |.      | |. ...|| ..|..| |..    |
.dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeq
0050432 (Phosphotyrosine protein) phosphatases II 2-129 1.1e-22 76.3 In-house 109-286 (308) alignment 
Range on Protein: 2-129
Range on HMM: 109-286/308.0
KFLITDRPTNSTLPQYIQDLKKYDAHTVVRVCEPTYNT--------------ETLSKEGIIV----------------------------------LDWP
||..|  |...|.  ... . ... ...|.......|               ..|  ... |                                  ..||
kfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWp

fDDGAAPPKQLVEDWLKLLKGKFkerPGSCVAVHCVAGLGRAPVLVALALI------ESGMKYEDAVEFIRRKRRGAINAKQ
 |.|. |  . . |.|.|.. ..   ||. ..||| ||.||. ...|| |.      | |. ...|| ..|..| |... ..
.dhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe
0051299 (Phosphotyrosine protein) phosphatases II 2-127 2.2e-22 75.3 In-house 93-271 (288) alignment 
Range on Protein: 2-127
Range on HMM: 93-271/288.0
KFLITDRPTNSTLPQYIQDLKKYDAHTVVRVCEPT-------------------------------------------------YNTETLSKEGIIVLDW
||..|  |...|.  . . . ... ...|......                                                 .. |..    . ...|
kfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnw

PfDDGAAPPKQLVEDWLKLLKGKFKeRPGSCVAVHCVAGLGRAPVLVALALI------ESGMKYEDAVEFIRRKRRGAINA
| |.|. .  .|. |.|.|.. ...  .|..|.||| ||.||. ...|| |.      | |. ...||...|..| |... 
p.dhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqt
0046845 (Phosphotyrosine protein) phosphatases II 2-127 2.8e-20 68.3 In-house 78-259 (284) alignment 
Range on Protein: 2-127
Range on HMM: 78-259/284.0
KFLITDRPTNSTLPQYIQDLKKYDAHTVVRVCEPTY-----------------------------------------------NTETLSKEGIIVLDWPf
||..|  |...|.  . . . .......| ..|..                                                . |..    . ...|| 
kfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswp.

DDGAAPPKQLVEDWLKLLKGKFKE-RPGSCVAVHCVAGLGRAPVLVALALIES---------GMKYEDAVEFIRRKRRGAINA
|.|. |  . . ..|.|..  ...  .|. ..||| ||.||. ...|| |. .         |. ...|| ..|..| |... 
dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqt
0036941 (Phosphotyrosine protein) phosphatases II 2-128 5.1e-19 64.1 In-house 79-263 (297) alignment 
Range on Protein: 2-128
Range on HMM: 79-263/297.0
KFLITDRPTNSTLPQYIQDLKKYDAHTVVRVCEPTYN-----------------------TETLSKEG--------------------------IIVLDW
||..|  |...|.  . . . ... ...| ..|.. .                        ..|| |                           . ...|
kfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgw

PfDDGAAPPKQLVEDWLKLLKGKFKER-PGSCVAVHCVAGLGRAPVLVALAL---------IESGMKYEDAVEFIRRKRRGAINAK
| |.|. .  . . |...|.. . |.  .|. | |||.||.||. ...|. |         .| |. . .|| ..|..| ||.   
p.dhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtl
0046846 (Phosphotyrosine protein) phosphatases II 3-137 9.3e-31 102.3 In-house 25-169 (176) alignment 
Range on Protein: 3-137
Range on HMM: 25-169/176.0
FLITDRPTNSTLPQYIQDLKKYDAHTVVRVCEP--------TYNTETLSKEGIIVLDWPFDDGAAPPKQLVEDWLKLLKGKFKErpGSCVAVHCVAGLGR
...|. |...||..... ||... ..||...|.        ..  . | |.|| .| .|..|. .|. .|....|....   ||  | .|.|||.||.||
piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealke..ggpvlVHCsaGigR

APVLVALALIES--GMKYEDAVEFIRRKRR-GAI-NAKQLSYLERYK
...|||. |.|.  |...|.|....|..|. ||. . .|. .|... 
tgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefe
0051429 (Phosphotyrosine protein) phosphatases II 3-136 4.4e-17 58.1 In-house 24-220 (272) alignment 
Range on Protein: 3-136
Range on HMM: 24-220/272.0
FLITDRPTNSTlPQYIQDLKKYDAHTVVRVCEPT---YNTETLSKEGIIVLDWPFDDGAAPPK-------------------------------------
.. ...|.. | .. .. ||... .|.| .....   ..   .  .|| .| .|. | .||.                                      
lyrsggplplt.aadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearev

---------------QLVEDWLKLLKGkfkerpGSCVAVHCVAGLGRAPVLVALALIESGMK--------------YEDAVEFIRRKRRGAI-NAKQLSY
               . . ..|.||        |  | ||| || .|  ..||| |.  |.               .|.||| .|..|.||. .  |. .
mhlhytdwpdhgvpqeallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylf

LERY
| ..
lyea
0051082 (Phosphotyrosine protein) phosphatases II 4-134 7.9e-25 82.6 In-house 16-145 (151) alignment 
Range on Protein: 4-134
Range on HMM: 16-145/151.0
LITDRPtnstLPQYIQDLKKYDAHTVVRVCEPT---YNTETLSKEGIIVLDWPFDDGAAPPKQLVEDWLKLLKGKFKERPGSCVAVHCVAGLGRAPVLVA
.... |    |..... ||...  |.| .....   |..| | ..|| ||..|..|  .|. .|  |... .  .. . .. .|.||| ||.||  .|||
yrsggp....ladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlva

LALIESGMKYEDAVEFIRRKRRGAINAKQLSYLE
| |.  |. .|.|.|..|.|| |... .|  ...
lylmllgvsleealeeyrlkrpgvvqpnqqflfq
0044763 (Phosphotyrosine protein) phosphatases II 5-138 3.5e-27 90.6 In-house 32-168 (178) alignment 
Range on Protein: 5-138
Range on HMM: 32-168/178.0
ITDRPTnstlPQYIQDLKKYDAHTVVRVCEPTY------NTETLSKEGIIVLDWPFDDGAAPP-KQLVEDWLKLLKGKFKeRPGSCVAVHCVAGLGRAPV
... |.    ..... ||... ...|...|...      . . ....|| .| .|..|. .|.  . .........   . ..|..|.||| ||.||...
lgslpp....addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgt

LVALALI-ESGMKYEDAVEFIRRKRRGAINAKQLSYLERYKP
|||. |. . |. .|.|.|..|..|.. .|  || .|... .
lvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefel
0049772 (Phosphotyrosine protein) phosphatases II 7-137 1.8e-23 79.2 In-house 152-274 (314) alignment 
Range on Protein: 7-137
Range on HMM: 152-274/314.0
DRPTNSTLPQYIQDLKkydahtvvrvcEPTYNTETLSKEGIIVLDWPFDDGAAPPKQLVEDWLKLLKGKfkeRPGSCVAVHCVAGLGRAP--VLVALALI
| ..|   ......||           | .|. | ....|| .|..|..|| ||. . ....|....     ..|..|.||| || ||..  |..|. ..
dgngneptaadlellk...........eelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmk

ESGMKYEDAVEFIRRKRR-----GAINAKQLsYLERYK
  |. .|.|.|..|.||      |.|.  .. |.....
llgvsleealedvrlkRpinpnpgfieqleq.yefile
PTEN_1 14-137 1.5e-26 88.4 In-house 56-189 (196) alignment 
Range on Protein: 14-137
Range on HMM: 56-189/196.0
LPQYIQDLKKYDAHTVVRVCE------PTYNTETLSKEGIIVLDWPFDDGAAPPKQLVEDWLKLLKGKFKERP-GSCVAVHCVAGLGRAPVLVALALIES
.... ..||. ....||...|      ..|. |.  |.|...|. |..|  ||. . . |..| ..   ...| | .|.||| |||||  ..||  |...
vaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmyk

G-MKYEDAVEFIRRKR-RGAIN-AKQLSYLERYK
| . ...|.|..|.|| .||.| ..|  .|| ..
gkltadeAlelvrekRppgapnspsqerlleyfa
0048179 (Phosphotyrosine protein) phosphatases II 15-137 3e-22 74.3 In-house 19-141 (144) alignment 
Range on Protein: 15-137
Range on HMM: 19-141/144.0
PQYIQDLKKYDAHTVVRVCEPtYNTETLSKEGIIVLDWPFDDGAAPPK-QLVEDWLKLLKGKFKerPGSCVAVHCVAGLGRAPVLVALALI-ESGMKYED
.. .. |||..  ||....|. |  | | .||| .| .|..|  .|.  .|....|....   .  .| .|.||| ||.||...|||. |. . |. .|.
aldlellkklgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmkklglslee

AVEFIRRKRRGAI-NAKQLSYLERYK
|....|..| ||. |  || .|..| 
alalvrsrrpgavpnpgqlrfLleye
0048076 (Phosphotyrosine protein) phosphatases II 15-136 2.6e-21 71.2 In-house 19-138 (145) alignment 
Range on Protein: 15-136
Range on HMM: 19-138/145.0
PQYIQDLKKYDAHTVVRVcepTYNTETLSKEGIIVLDWPFDDGAAPPK-QLVEDWLKLLKGKFKErpGSCVAVHCVAGLGRAPVLVALALIES-GMKYED
.. .. ||...  ||...   |...| |...|| .| .|..|  .|.  .|....|....   ||  | .|.||| ||.||...|||. |. . |. .|.
aldlellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmlllgvslee

AVEFIRRKRRGAI-NAKQLSYLERY
|.|..|..|.||. |  || .|...
alelvrsqrpgavpnpgqlrflyef
subfamily_CDC14_pd Subfamily CDC14 15-136 6.3e-19 63.0 In-house 202-319 (328) alignment 
Range on Protein: 15-136
Range on HMM: 202-319/328.0
PQYIQDLKKYDAHTVVRVCEPTYNTETLSKEGIIVLDWPFDDGAAPPKQLVEDWLKLLKGKfkerpGSCVAVHCVAGLGRAPVLVALALIE-SGMKYEDA
 ....  .|.. .||||. .  |. ..  ..|.   |  | ||. |....|. .|....          .|||| |||||.  |.|  |..  ..  ..|
eklleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacylmkhyrftaaea

VEFIRRKRRGAINAKQLSYLERY
. ..|  | | . ..| ..||. 
iawlricrPGsvigpqqkfleek
0048567 (Phosphotyrosine protein) phosphatases II 23-135 1.2e-12 42.5 In-house 14-132 (157) alignment 
Range on Protein: 23-135
Range on HMM: 14-132/157.0
KYDAHTVVRVCEPTYNTETL-SKEGIIVLDWPFDDGaAPPKQLVEDWLKLLKGKFK--ERPGSCVAVHCVAGL---GRAPVLVAL-ALIESGMKYEDAVE
.. .....|. . .||.  .   .|.. .|. ||.|  ..  .. .. ..|. ..|  |  |  .|||| |||   ||. .|... ...  |.  |.|..
rlyfallprlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaia

FIRRKRRGAINAKQLSYLER
..|  | | .   . |||..
plrivrpgsvpfrdasylls
subfamily_PTEN_pd Subfamily PTEN 24-122 2.2e-10 35.8 In-house 59-157 (184) alignment 
Range on Protein: 24-122
Range on HMM: 59-157/184.0
YDAHTVVRV-CEPTYNTETLSKEgiiVLDWPFDDGAAPPKQLVEDWLKLLKGKFKERPGSCVAVHCVAGLGRAPVLVALALIESGMKY--EDAVEFIRRK
 | . .  .  | .|........   |  .||||  .|| .|.|. .. ..  ..| .   |.||| || ||. ||..  |..|..    |.|.|.  ..
kdhykiynlrserkydskkfdgr...vavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaea

RR
| 
Rt
subfamily_PTPN12_pd Subfamily PTPN12 28-113 9.1e-06 19.8 In-house 156-239 (290) alignment 
Range on Protein: 28-113
Range on HMM: 156-239/290.0
TVVRVCEPTYNTETLSKEGIIVLDWPFDDGAAPPKQLVEdWLKLLKgKFKERPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDA
 ..|  . . . |. . . .   .||  .  . .|.|.|  ..|.. ...|.  . ..||| || ||. ...|. .. . .| |  
flirtLkveaqkesrkvyqfhYtaWPDhgvPssakslle.lielvr.elqesedaPlvvhCsaGvGrtGtiiaidyvrellkaeki
subfamily_RNGTT_pd Subfamily RNGTT 34-139 9.2e-10 32.5 In-house 65-174 (189) alignment 
Range on Protein: 34-139
Range on HMM: 65-174/189.0
EPTYNTETLSKEGIIVLDWPFD-DGAAPPKQLVEDWLKLLKGKFKERPGSCVAVHCVAGLGRAPVLVALALIES-GMKYEDAVEFIRRKRRGAINAKQL-
.. |..| |.||||          |.|| .. |. . ||..  ||..| . ..|||  |  |.  |..  |.|   .. |.||.  .. |   |  ..  
sryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedyl

-SYLERYKPT
  .|.||. .
kellrrYadv
subfamily_PTPDC1_pd Subfamily PTPDC1 36-133 8e-15 49.7 In-house 72-168 (182) alignment 
Range on Protein: 36-133
Range on HMM: 72-168/182.0
TYNTETLSKEGIIVLDWPFDDGAAPPKQLVEDWLKLLKGKFKERpgsCVAVHCVAGLGRAPVLVALALI-ESGMKYEDAVEFIRRKRRGAINAK-QLSYL
.|..| | ..||.|  ....|  ... . . |  |...   .|     ||||| |||||. ||.|  |.  . .. |.|....| ||  .|... |.  .
sYdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelv
subfamily_PTPMT1_pd Subfamily PTPMT1 37-138 1.3e-10 36.0 In-house 64-166 (171) alignment 
Range on Protein: 37-138
Range on HMM: 64-166/171.0
YNTETLSKEGIIVLDWPFDDGA-APPKQLVEDWLKLLKGKFKErpGSCVAVHCVAGLGRAPVLVALALI-ESGMKYEDAVEFIRRKRRG-AINAKQLSYL
 .||. .|.|.  |  .  | . ||  . .|. .....   ..  |..| ||| || ||.  |||  |. .. .. |.|......||.   .. ||.. |
nsteewkklgveqlqlatvDfteapdleklekgvefiekvask..gkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkal

ERYKP
..|. 
qeyee
subfamily_DSP11_pd Subfamily DSP11 37-126 8.6e-07 23.0 In-house 70-162 (178) alignment 
Range on Protein: 37-126
Range on HMM: 70-162/178.0
YNTETLSKEGIIVLDWPFDDGAAPPKQLVEDWLKLLKGKF--KERPGSCVAVHCVAGLGRAPVLVALALIE-SGMKYEDAVEFIRRKRRGAIN
|....|..||.  |         | ..||... . .|     ..  .. ..|||  |. |.  |.   ||.  |.. |||.|   . |  ...
ykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhsle
DSPc Dual specificity phosphatase, catalytic domain 40-127 1.9e-09 32.5 Pfam-A 33-119 (133) alignment 
Range on Protein: 40-127
Range on HMM: 33-119/133.0
ETLSKEGIIVLDWPFDDgaaPPKQLVEDWLKLLKGKF--KERPGSCVAVHCVAGLGRAPVLVALALIE-SGMKYEDAVEFIRRKRrGAINA
 . .|. |  |. | .|     .. ....|. ..      |. |  |.||| ||. | . |..  |..  ......|.||....| ..|. 
naikkseieylripved...etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr.skisp
DSPc Dual specificity phosphatase, catalytic domain 40-127 1.9e-09 32.5 In-house 33-119 (133) alignment 
Range on Protein: 40-127
Range on HMM: 33-119/133.0
ETLSKEGIIVLDWPFDDgaaPPKQLVEDWLKLLKGKF--KERPGSCVAVHCVAGLGRAPVLVALALIE-SGMKYEDAVEFIRRKRrGAINA
 . .|. |  |. | .|     .. ....|. ..      |. |  |.||| ||. | . |..  |..  ......|.||....| ..|. 
naikkseieylripved...etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr.skisp
subfamily_CDKN3_pd Subfamily CDKN3 43-137 8.1e-09 29.3 In-house 96-192 (202) alignment 
Range on Protein: 43-137
Range on HMM: 96-192/202.0
SKEGIIVLDWPFDDGAAPPKQLVEDWLKLLKGKFKERPGscVAVHCVAGLGRAPVLVAL--ALIESGMKYEDAVEFIRRKR-RGAIN-AKQLSYLERYK
.. |.||  .|. || .|      . |. |.  .|.  .    |||  ||||. ...|    ...  ....||.. .|  .  .||.  ||  ||. ..
qqaglivhhypiadglvpdiasclkileelrinlkayrk..tlvhcygglgrsslviaclllylddtiepkdaidklrdlkgsraiqtvkqynylsefr
PTPc_motif_SM00404 44-127 2.1e-09 32.4 In-house 44-126 (140) alignment 
Range on Protein: 44-127
Range on HMM: 44-126/140.0
KEGIIVLDWPFDD-GAAPPKQLVEDWLKLLKGKfkERPGSCVAVHCVAGLGRAPVLVALALIE-SGMKYEDAVEFIRRKRrGAINA
..|. .|  | || . ..  .  .  |. ..    |. |  | ||| ||. |   |..  |..  ......|.||....|  .|. 
nsgfqilqiplddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerR.piisp
subfamily_DSP23_pd Subfamily DSP23 46-128 7.9e-09 30.3 In-house 51-132 (148) alignment 
Range on Protein: 46-128
Range on HMM: 51-132/148.0
GIIVLDWPFDDGAAPPKQLVEDWLKLLKGKfkERPGSCVAVHCVAGLGRAPVLVALALI-ESGMKYEDAVEFIRRKRRGAINAK
.. .     ||   |  . |........    |  .  |.|||. | ||.  ..|  |. | ..   .|.  .||.| |.... 
nltlvrlriddyhppaleqvvefvrvveea..eekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetv
PTPc_DSPc_SM00012 49-128 1.3e-09 33.5 In-house 7-93 (105) alignment 
Range on Protein: 49-128
Range on HMM: 7-93/105.0
VLDWPFDdGAAPPKQLVEDWLKLLKGKFKERP-GSCVAVHCVAGLGRAPVLVALALIESGMKYE-------DAVEFIRRKRRGAINAK
...||   |.  . . . ..|. .| . ...  .. | ||| || ||. ..|||... . ...|       . |. .|..|.|... .
ytgwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte
Y_phosphatase Protein-tyrosine phosphatase 49-130 2.5e-08 29.0 Pfam-A 140-226 (235) alignment 
Range on Protein: 49-130
Range on HMM: 140-226/235.0
VLDWPfdDGAAPPKqlVEDWLKLLKGKFKER--PGSCVAVHCVAGLGRAPVLVALALIESGMKY------EDAVEFIRRKRRGAINA-KQL
. .||  |  .| .  ... |.|..   |..    . | ||| || ||. ..||| .. . ..        ..|. .|..|.|...  .|.
ytnWp..dhgvpes..pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqY
Y_phosphatase Protein-tyrosine phosphatase 49-130 2.5e-08 29.0 In-house 140-226 (235) alignment 
Range on Protein: 49-130
Range on HMM: 140-226/235.0
VLDWPfdDGAAPPKqlVEDWLKLLKGKFKER--PGSCVAVHCVAGLGRAPVLVALALIESGMKY------EDAVEFIRRKRRGAINA-KQL
. .||  |  .| .  ... |.|..   |..    . | ||| || ||. ..||| .. . ..        ..|. .|..|.|...  .|.
ytnWp..dhgvpes..pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqY
subfamily_PTPN13_pd Subfamily PTPN13 49-137 7.2e-07 23.7 In-house 173-263 (273) alignment 
Range on Protein: 49-137
Range on HMM: 173-263/273.0
VLDWPFDDGAAPPKQLVEDWLKLLkgKFKErPGSCVAVHCVAGLGRAPVLVALA----LIE--SGMKYEDAVEFIRRKRRGAINAKQlSYLERYK
  .||  .  . ...|..   ..   ....   . ..||| ||.||. .|...     |||    .. .. |. .|..|.| . .|.  |.  ||
fvkwPdhgvPssaaellqfvaevr..rlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkd.qyifvyk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 50-116 1.5e-06 22.5 In-house 185-252 (297) alignment 
Range on Protein: 50-116
Range on HMM: 185-252/297.0
LDWPFDDGAA-PPKQLVEDWLKLLKGKFKERPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAVEF
..|| ..       . . .... .. .|...  . . |||.||.||. ||...  . . .| |..|. 
veWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdi
subfamily_Slingshot_pd Subfamily Slingshot 79-134 1.9e-06 21.4 In-house 94-151 (169) alignment 
Range on Protein: 79-134
Range on HMM: 94-151/169.0
RPGSCVAVHCVAGLGR-APVLVALALIESGMKYEDAVEFIRRKRRGA-INAKQLSYLE
. || | |||  |. | | ...| |. | |...|.|.|.....|. .  |.  |. ||
kkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqle
subfamily_DSP10_pd Subfamily DSP10 79-122 8.4e-06 19.7 In-house 90-134 (159) alignment 
Range on Protein: 79-122
Range on HMM: 90-134/159.0
RPGSCVAVHCVAGLGRA-PVLVALALIESGMKYEDAVEFIRRKRR
. || | ||| ||. |.  | .|  . . ... .|| .|.. || 
kkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrp
subfamily_DSP3_pd Subfamily DSP3 80-134 1.3e-06 22.2 In-house 96-151 (162) alignment 
Range on Protein: 80-134
Range on HMM: 96-151/162.0
PGSCVAVHCVAGLGRAPVL-VALALIESGMKYEDAVEFIRRKRRGAINAKQLSYLE
. . | ||||.|. |...| .|  .|   |.  .|.. .|.||.   |   |  | 
kegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkReilPneGFlkqLa
subfamily_DSP15_pd Subfamily DSP15 81-144 5.3e-08 27.1 In-house 78-143 (151) alignment 
Range on Protein: 81-144
Range on HMM: 78-143/151.0
GSCVAVHCVAGLGRAPVLVALALIE-SGMKYEDAVEFIRRKRRGAI-NAKQLSYLERYKPTKLLKE
.  | |||.||. |.  ||.. |.    ....||.|.|. .|  |  |.   . |. |. ||| ..
eenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklkey
subfamily_DSP12_pd Subfamily DSP12 81-130 7.9e-06 20.3 In-house 82-133 (155) alignment 
Range on Protein: 81-130
Range on HMM: 82-133/155.0
GSCVAVHCVAGLGRA-PVLVALALIESGMKYEDAVEFIRRKRRGA-INAKQL
.  | ||| ||. |   . .|  . ..... |.|......|.. .  |.  |
egavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFl
subfamily_DSP8_pd Subfamily DSP8 81-134 9.3e-06 19.3 In-house 93-145 (159) alignment 
Range on Protein: 81-134
Range on HMM: 93-145/159.0
GSCVAVHCVAGLGRAPV-LVALALIESGMKYEDAVEFIRRKRrGAINaKQLSYLE
 ..| ||. ||  |..   .|  . .  |....| .|.. ||  .|. ..| .|.
ngrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekr.ptis.pnlnflg
subfamily_DSP19_pd Subfamily DSP19 82-124 5.6e-06 20.8 In-house 90-133 (152) alignment 
Range on Protein: 82-124
Range on HMM: 90-133/152.0
SCVAVHCVAGLGRAP-VLVALALIESGMKYEDAVEFIRRKRRGA
 .| ||| ||  |.. | .|  . .  ...|.|.| .| .|. .
gavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpci
subfamily_DSP1_pd Subfamily DSP1 83-122 4.2e-06 21.0 In-house 97-137 (163) alignment 
Range on Protein: 83-122
Range on HMM: 97-137/163.0
CVAVHCVAGLGRAPVLVALALIE-SGMKYEDAVEFIRRKRR
 | .|| ||. |.  |. . |.. . ...|.| .|....| 
kvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRs