Gene PTPMT1-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PTPMT1
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP018_AA protein Get Run
NvecP018_AA_38-178 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PTEN_1 16-155 4.2e-26 87.0 In-house 7-157 (196) alignment 
Range on Protein: 16-155
Range on HMM: 7-157/196.0
SVGARVLFYPTLLWNVVMEGGSRR----WYDR-----IDSTVILGALPFKSLTQKLVEEENVRAVVTLNEEFETkH-FCNTSEEWSEWGVKQLRLATVDF
.. .. |..||.|... .   ..     ...|     || ....| |.. .   .  .|.....||.|.||.|. . .  . ||. . ||..|..   |.
rsskknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeel.sgrsydleeffksgveylhfpieDh

GNAPSLDNLSEGVKFIEEIRS--KGDSVYVHCKAGRGRSATLVACYLMKSKR
|  .    . . ..||| ..|  .|  |.||||||.|||.|.||.|||....
gapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk
subfamily_PTPMT1_pd Subfamily PTPMT1 23-177 4.5e-71 232.8 In-house 1-170 (171) alignment 
Range on Protein: 23-177
Range on HMM: 1-170/171.0
FYPTLLWNVVMEGGSRR-WYDRIDSTVILGALPFKSLTQKLVEEENVRAVVTLNEEFETKHFCNTSEEWSEWGVKQLRLATVDFGNAPSLDNLSEGVKFI
||||||.||..|..|.| ||||||.|||||||||.||...|.|.|||.|||.||||.|.|...|..|||...||.||.|||||| .||.|..|..||.||
fyPtllynvlvekaskrnwydriDdtvilGalPfrslikeLiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefi

EEIRSKGDSVYVHCKAGRGRSATLVACYLM--------------KSKRPHIRLASQQWSAVQQFHDYLHE
|...|||..|||||||||||||||||||||              |.||..||||..||.|.|.... |..
ekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeeklls
0044763 (Phosphotyrosine protein) phosphatases II 27-178 9.1e-30 99.0 In-house 9-173 (178) alignment 
Range on Protein: 27-178
Range on HMM: 9-173/178.0
LLWNVVMEGGSRRWYDRIDSTVILGALPFkSLTQKLVEEENVRAVVTLNEEFETKHFCNTSEEWSEWGVKQLRLATVDFGNAPSLDNLSEGVKFIEEIR-
| .   .|..   ....|.  ..||.||  .   .|. |......|.|.||.|  .. .  . ..| |.. |.. ..|.|. ..|. . | |.||||.. 
lsnleglersdyinaseilpglylgslpp.addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald

SKGDSVYVHCKAGRGRSATLVACYLM--------------KSKRPhIRLASQQWSAVQQFHDYLHED
.||  |.|||.||.|||.||||.|||              ...|| |     |.  ...|. .|.. 
ekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllke
0046846 (Phosphotyrosine protein) phosphatases II 33-176 1.4e-31 104.9 In-house 4-173 (176) alignment 
Range on Protein: 33-176
Range on HMM: 4-173/176.0
MEGGSRRWYDRIDSTVILGALP----------FKSLTQKLVEEeNVRAVVTLNEEFETKHF--CNTSEEWSEWGVKQLRLATVDFGNAPSlDNLSEGVKF
.. | . ..|.|.  .|||..|          . .  . | |. ...|||.|.||.|....  .|  .|. . |.. |.| ..|.|  .. . | | ..|
rllgldldldyinanlilgsrpiatqgplprtladflemlkel.gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellef

IEEIRSKGDSVYVHCKAGRGRSATLVACYLMKS---------------KRP-HIRLASQQWSAVQQFHDYLH
|.| ...|  |.|||.||.||..||||.||...               .|| ..    .|.  ...|. .|.
irealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll
0041856 (Phosphotyrosine protein) phosphatases II 37-171 4.7e-24 80.4 In-house 15-166 (182) alignment 
Range on Protein: 37-171
Range on HMM: 15-166/182.0
SRRWYDRIDSTVILGALPF--------------KSLTQKLVEEeNVRAVVTLNeefetkHFCNTSEEWSEWGVKQLRLATVDFGNAPsldnLSEGVKFIE
  |..|.|   ..||.||.               .  . | |. .....|.|.       ..   |..  .|.. |.|   |.|  .    |.| ..|||
hsrdldyInanlylgslpatrfiatqgpllstvadflrmlkel.gittivnlt......eelywpellerlgiqylylpwpDhgvpd....ldelldfie

EIRSKGDSVYVHCKAGRGRSATLVACYLMK--------------SKRPHIRLASQQWSAVQQF
|....|  |.|||.||.||..||||.||||              |.||..    .|.  .|..
evleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqla
0048076 (Phosphotyrosine protein) phosphatases II 39-175 1.6e-24 81.6 In-house 2-142 (145) alignment 
Range on Protein: 39-175
Range on HMM: 2-142/145.0
RWYDRIDSTVILGALPfKSLTQKLVEEENVRAVVTLneefetkhfCNTSEEWSEWGVKQLRLATVDFGNAPSLDNLSEGVKFIEEIRSKGDSVYVHCKAG
 |...|.  . || ||   |  .| .. ....|..|         ... | ... |.. |.| . |.|  ..|. | | ..||||....|  |.|||.||
ywpseilpglylgslp.taldlellkdlgittvlnl.........tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaG

RGRSATLVACYLMKS--------------KRPHIRLASQQWSAVQQFHDYL
.||..||||.|||..              .||..    .|.  ...|. .|
vgRtgtlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0045098 (Phosphotyrosine protein) phosphatases II 39-176 6.1e-24 80.3 In-house 37-272 (278) alignment 
Range on Protein: 39-176
Range on HMM: 37-272/278.0
RWYDRI--------------------DSTVILGALPFKSLT---QKLVEEENVRAVVTLNEEFET-----------------------------------
 .|  |                    . . |. . |..| .    ... |......|.|.|..|                                    
nRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytl

-----KHFCNTSEEWSEWGVKQLRLATVDFGNAPSLD---NLSEGVKFIEEIRS--------------KGDSVYVHCKAGRGRSATLVACYLMKSK----
      ....  |.. ..||..| . ... ...|||.    . | ..||.| ..              .|  |.|||.|| ||..||||.|||..     
rtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlellegg

-------------RPH-IRLASQQWSAVQQFHDYLH
             ||. .    .|.  . .|. .|.
vdlleavkelrsqRpglavqnleqyrflyefllell
0038934 (Phosphotyrosine protein) phosphatases II 40-176 8e-26 86.3 In-house 12-177 (194) alignment 
Range on Protein: 40-176
Range on HMM: 12-177/194.0
WYDRIDSTVILGALPFKSLTQKLVEEENVRAVVTLNEEFETKHF-------------CNTSEEWSEWGVKQLRLATVDFGNAPSLDNLSEGVKFIEEIRS
. |.|   .|  ..| ..  .| .||... .. .| . .....              .   ||. . |.. |.| ..|.|..|||..| . .....|. .
vgdiitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefln

K--GDSVYVHCKAGRGRSATLVACYLMK--------------SKRPHIRLASQQWSAVQQFHDYLH
.  |  |.||||||.||..||||.||..              .|||..    ....|...... | 
edpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelr
0048179 (Phosphotyrosine protein) phosphatases II 40-175 1.7e-24 81.6 In-house 3-144 (144) alignment 
Range on Protein: 40-175
Range on HMM: 3-144/144.0
WYDRIDSTVILGALPfKSLTQKLVEEENVRAVVTLNEEFETKHFCNTseewsewGVKQLRLATVDFGNAPSLDNLSEGVKFIEEIRSKGDSVYVHCKAGR
....|.. . || ||  .|  .|  . ....|..|.||.|  .. ..       |.. |.| . |.|  ..|. | | ..||||....|  |.|||.||.
npseilpglylgslp.taldlellkklgittvinlteeyepeflere.......giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGv

GRSATLVACYLM--------------KSKRPHIRLASQQWSAVQQFHDYL
||..||||.|||              .|.||..    .|.  .......|
gRtgtlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekll
0051082 (Phosphotyrosine protein) phosphatases II 40-174 7.6e-24 79.4 In-house 7-128 (151) alignment 
Range on Protein: 40-174
Range on HMM: 7-128/151.0
WYDRIDSTVILGALPFKsLTQKLVEEENVRAVVTLNEEFETKhfcNTSEEWSEWGVKQLRLATVDFGNAPSLDNLSEGVKFIEEIRSK-GDSVYVHCKAG
.. .... ..... |      .|..|......|.|..|.|..   .  | . |.|.. |..  .|. . .  ... . ..|.|....| .  |.|||.||
nfsyvtgglyrsggpla.dflellkelgiktivnlrseeerg...ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaG

RGRSATLVACYLMKSKrphirlasqqWSAVQQFHDY
.||..||||.|||. .          .|. . ...|
kgRTGtlvalylmllg..........vsleealeey
0037934 (Phosphotyrosine protein) phosphatases II 41-173 1.9e-21 72.2 In-house 39-239 (243) alignment 
Range on Protein: 41-173
Range on HMM: 39-239/243.0
YDRIDSTVILGALPFKSLTQK-------LVEEENVRAVVTLNEEFETKHF-----------------------------------CNTS-EEWSEWGVKQ
. ..  ..|.. .| .. ..        .. |......|.|.|..| ...                                   .|.. ....  ... 
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

LRLATVDFGNAPSLDNLSEGVKFIEE---------IRSKGDSVYVHCKAGRGRSATLVACYLMKSK---------------RPH-IRLASQQWSAVQQFH
..|.  |.|  .| ..| . .... |          ...|  |.|||.||.||..||.|.|||...               ||. .    .|.  .....
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal

D
 
l
0042113 (Phosphotyrosine protein) phosphatases II 42-174 8.5e-24 79.7 In-house 48-241 (245) alignment 
Range on Protein: 42-174
Range on HMM: 48-241/245.0
DRIDSTVILGALPFKSlTQK----LVEEENVRAVVTLNEEFETKH-------------------------------------FCNTSEEWSEWGVKQLRL
.||  ..|... | .. | .    .. |......|.|.||.| ..                                       |. . .|  ..  ..|
yritpkfiatqgPlpe.tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhyl

ATVDFGNAPSLDNLSEGVKFIEEIRS--KGDSVYVHCKAGRGRSATLVACYLM-------------------KSKRPHIRLASQQWSAVQQFHDY
   |.| ...|. | . ..|......  ..  |.|||.||.||..|..|.|||                   .|.||...   .|.  ..... .
pwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 42-173 1.5e-21 72.6 In-house 97-286 (297) alignment 
Range on Protein: 42-173
Range on HMM: 97-286/297.0
DRIDSTVILGALPFKSLT---QKLVEEENVRAVVTLNEEFETKHFC----------------NTSEEWSEWGVKQLRL-----------------ATVDF
|... ..|.   | .. .    ..| |..|...|.|....| .. |                .. ..  . |...  |                    |.
dlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdh

GNAPSLDNLSEGVKFIEEIRS---KGDSVYVHCKAGRGRSATLVACYLM-------------------KSKRPHIRLASQQWSAVQQFHD
|  |||. | | .....|...   ||  |.|||.|| ||..|..|.|||                   ...||...   .|.  ....  
gvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall
0036282 (Phosphotyrosine protein) phosphatases II 43-176 2.8e-25 84.4 In-house 14-170 (174) alignment 
Range on Protein: 43-176
Range on HMM: 14-170/174.0
RIDSTVILGALPFKslTQKLVEEENVRAVVTLNEEFETK------HFCNTSEEWSEWGVKQLRLATVDFGNAPSLDnLSEGVKFIEEIRSK--GDSVYVH
.| . .|.|. |..    ... |.....||.|.||.| .       .  ..| ... |.. |.| ..|.|  ..   | | |||.||..|.  |  |.||
yitprliagqgpla..fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

CKAGRGRSATLVACYLMKSKR------------------PHIRLASQQWSAVQQFHDYLH
|.||.||..||||.|||.                     |..    .|.  ...|...|.
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfeklls
PTPc_motif_SM00404 43-158 1.9e-18 61.7 In-house 4-110 (140) alignment 
Range on Protein: 43-158
Range on HMM: 4-110/140.0
RIDSTVILGALPFKSlTQKLVEEENVRAVVTLNEEFETKhfcntseeWSEWGVKQLRLATVDFGNAPSLDNLSEGVKFIEEIRSKGDSVYVHCKAGRGRS
||   ..|| .. ..  ..| .. ....|. . || . .         .. |.. |..   | .... .. |.. ..|||....|| .|.|||.||  ||
rilphlylgskskaq.npallkklgithvinvteevslt........kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRS

ATLVACYLMKSKRPHI
|||...|||...   .
atliiaYlmryrqlsl
subfamily_DSP12_pd Subfamily DSP12 43-166 3.3e-17 57.3 In-house 4-120 (155) alignment 
Range on Protein: 43-166
Range on HMM: 4-120/155.0
RIDSTVILGALPFKSLTqKLVEEENVRAVVTLNEEFEtkhfCNTSEEWSEWGvkQLRLATVDFGNAPSLDNLSEGVKFIEEIRSKGDSVYVHCKAGRGRS
||.  . || |.    . .| .| .. .|... .|       . ......    .. .  .|  ... |..| | |.|||| ......|.|||.||  ||
rilpglylggleavqee.ellkelkithvlsvikeel....pehklkkgkvs..tkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRS

ATLVACYLMKSKRPHIRLASQQWS
.|.|. ||||...  .  | .  .
vtiviAYlmkkeklslekAlklvk
0040439 (Phosphotyrosine protein) phosphatases II 44-171 1.3e-18 62.9 In-house 52-241 (249) alignment 
Range on Protein: 44-171
Range on HMM: 52-241/249.0
IDSTVILGALPFKSLT---QKLVEEENVRAVVTLNEEFETK-----------------------------------HFCNTS-EEWSEWGVKQLRLATV-
|  ..|.   | .. .    ... |......|.|....| .                                   ... |  .. ..  |....     
ikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp

DFGNAPSLDNLSEGVKFIEEIRS---KGDSVYVHCKAGRGRSATLVACYLM-------------------KSKRPHIRLASQQWSAVQQF
|.|  ||.. | . .. ......   ||  |.|||.|| ||..|..|.|||                   .|.||..    .|.  ....
dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea
0043336 (Phosphotyrosine protein) phosphatases II 45-171 1.4e-18 62.8 In-house 87-272 (278) alignment 
Range on Protein: 45-171
Range on HMM: 87-272/278.0
DSTVILGALPFKSLT---QKLVEEENVRAVVTLNEEFETKH----------------------------------FCNT--SEEWSEWGVKQLRLATVDF
  ..|.   | .. .    ..| |..|. .|.|.|..| ..                                  .. |   . .| ...    |.  |.
prkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdh

GNAPSLDNLSEGVKFIEEIRS-KGDSVYVHCKAGRGRSATLVACYLM-------------------KSKRPHIRLASQQWSAVQQF
|  .||. | . .|.. |... ..  |.|||.|| ||..|..|.||.                   ...||..    .|.  . ..
gvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 47-167 1.1e-10 35.2 In-house 14-125 (148) alignment 
Range on Protein: 47-167
Range on HMM: 14-125/148.0
TVILGALPFKSLTQkLVEEENVRAVVTLNEEFEtKHFCNTseewsewGVKQLRLATVDfGNAPSLDN-LSEGVKFIEEIRSKGDSVYVHCKAGRGRSATL
 . ||. ....  .  ... .| ..|. ..| . . . .        |.. | .|  |  .   |     . ..|... ...|  | ||.. |. ||. |
fLFlGskksaadle.alkalgvtrivnatkerd.naldqr.......gieYlhvaldD.kpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssal

VACYLMKSKRPHIRLASQQWSA
.  .|.. ||  ...| .    
allwlidfkrvslkealalvks
subfamily_DSP23_pd Subfamily DSP23 52-155 3.2e-14 47.8 In-house 16-111 (148) alignment 
Range on Protein: 52-155
Range on HMM: 16-111/148.0
ALPFKSLTQKLVEEENVRAVVTLNEEFETKhfcntSEewSEWGVKQLRLATVDFgNAPSLDNLSEGVKFIEEIRSKGDSVYVHCKAGRGRSATLVACYLM
|||      . . .  || .|.| || . .     .|  .  ..   ||   |.   |.|... | |. .||  .|...| |||  ||||. |..||||.
alprlpdqyrylldlgvrylvslteegrph.....ve..atpnltlvrlriddy.hppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylv

KSKR
| ..
kerk
subfamily_Tensin_pd Subfamily Tensin 52-173 5.2e-08 25.6 In-house 24-149 (189) alignment 
Range on Protein: 52-173
Range on HMM: 24-149/189.0
ALPFKSLTQKLVeeENVRAVVT-LNEEFETKH-FCNTSEEwsEWGVKQLRLATVDFG----NAPSLDNLSEGVKFIEEI-RSKG-DSVYVHCKAGRGRSA
..| ..| .| .  ||.. |.  |... . |    | ||   .. ...|    .|||     ||||. |.  .| ...  ...  . | |||| |.|| .
sfpaegleekyr..enlkdvakllkskhndkylvfnlsek..rydisklnkkvldfGWPdllaPsleklcsicksldsWlkadpqnvvvvhckGgkgrig

TLVACYLMKSKRPHIRLASQQWSAVQQFHD
 .|..|.  ||      |. .. |...| |
vvvsaymkyskisasadaaldrfamkrfld
subfamily_DSP8_pd Subfamily DSP8 56-153 1.2e-11 38.4 In-house 29-118 (159) alignment 
Range on Protein: 56-153
Range on HMM: 29-118/159.0
KSLTQKLVEEENVRAVVTlneefeTKHFCNTSEEWSEwgVKQLRLATVDFGNAPSLDNLSEGVKFIEEIRSKGDSVYVHCKAGRGRSATLVACYLMKS
..| ..|... ..  |.       ... | ..|| .|  .| ||.   |  .   |. . . |.||. ..|.  .| ||. ||. ||||.. .|.|| 
dvlseellsklgisyvln......asnscpkleelke..skflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayimkt
subfamily_DSP14_pd Subfamily DSP14 57-161 1.8e-12 41.5 In-house 21-116 (157) alignment 
Range on Protein: 57-161
Range on HMM: 21-116/157.0
SLTQKLVEEENVRAVVTLNEEFETKHFCNTSeewsewgvkQLRLATVDFGNAPSLDNLSEGVKFIEEIRSKGDSVYVHCKAGRGRSATLVACYLMKSKRP
.|...|...... ... .  |  .... . .         .....  |  .|   . . | .. |||.. ||  . |||.||. |||.|.  |||| .. 
alskellkkkkitliinvtvelpntklkdie.........rvkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyekl

HIRLA
 .| |
sLrea
subfamily_DSP15_pd Subfamily DSP15 59-153 3.9e-13 43.8 In-house 19-103 (151) alignment 
Range on Protein: 59-153
Range on HMM: 19-103/151.0
TQKLVEEENVRAVVTLNEefetkhfcNTSEEWSEwgVKQLRLATVDFGNAPSLDNLSEGVKFIEEIRSKGDSVYVHCKAGRGRSATLVACYLMKS
 ..|..|.|.  ......        |. .   .  .. . .|  |  .|     ..| |.|| . |.|...|.||| ||  ||.|||. |||  
deelLkeknithilsvhd........nakkllkd..ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtv
0051429 (Phosphotyrosine protein) phosphatases II 60-171 5.4e-17 57.8 In-house 39-220 (272) alignment 
Range on Protein: 60-171
Range on HMM: 39-220/272.0
QKLvEEENVRAVVTLNEEFETKHfCNTSEEWseWGVKQLRLATVDFGNAPSLDNL---------------------------------------------
..| .|......|.| .|.| .. .... .|   |.. |.| ..|..  . | .                                              
wrl.kelgiktivdLrseeErgr.lkcdryw..pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhg

---SEGVKFIEEIRSkGDSVYVHCKAGRGRSATLVACYLMKSKRP---------------------------HIRLASQQWSAVQQF
   .. ....|.... |  |.|||.||..|..|.||..|.    .                           ...   .|.  ....
vpqeallellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyea
subfamily_STYXL1_pd Subfamily STYXL1 60-163 2.3e-11 37.2 In-house 30-127 (157) alignment 
Range on Protein: 60-163
Range on HMM: 30-127/157.0
QKLVEEENVRAVVTLNEEFETkhFCNTSEEwsewGVKQLRLATVDFGNAPSLDNLSEGVKFIEEIRSKGDSVYVHCKAGRGRSATLVACYLMKSKRPHIR
... ..  |.|.| .  . .   . .. ..     .| |..|  |  .|  |..|.| |.|||. . .|. | |  . |  |||.....||| ||.   .
paikkdlkvkahvnvsmdadk..liagvad....vakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlk

LASQ
 | .
kayk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 60-154 2.8e-06 21.5 In-house 153-235 (307) alignment 
Range on Protein: 60-154
Range on HMM: 153-235/307.0
QKLVEEENVRAVVTLNEEFETKHFCNTSEEWSEWGvkqlrlatvDFGnAPSLdNLSeGVKFIEEIRSKGDSVYVHCKAGRGRSATLVACYLMKSK
.||  .|..  | ||. ..  |  . .  .|..|          | | .| . ||.  . ..| .| . . | ||| || ||| |.||  |.. |
kklapdedlinvttlkvdwaqksrtiqhlqwenwp.........drg.vpqi.nlt.ainlleavrydtnpvvvhcsaGvGrsGtivaislvqdk
0043147 (Phosphotyrosine protein) phosphatases II 61-175 1e-22 76.1 In-house 38-160 (172) alignment 
Range on Protein: 61-175
Range on HMM: 38-160/172.0
KLVEEENVRAVVTLNEEfetkhfCNTSEEWSEWGVKQLRLATVDFGNApSLDNLSEGVKFIEE--IRSKGDSVYVHCKAGRGRSATLVACYLM-------
... |......|.|.|.      ... |  .. |.. |.|   |.|   .|. | | ..||.|  ..|.|  |.|||.|| ||..||||.|||       
rmlkelgithivnltel......lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylmllglsle

------KSKRPHIRLASQQWSAVQQFHDYL
      ..|||..    .|.  ...|...|
eavalvrekRpgavqnpsqyrflyyfekll
0049260 (Phosphotyrosine protein) phosphatases II 61-175 1.3e-22 75.6 In-house 27-149 (152) alignment 
Range on Protein: 61-175
Range on HMM: 27-149/152.0
KLVEEENVRAVVTLNEEFEtkhfcnTSEE-----WsewgvKQLRLATVDFGNAPSLDNLSEGVKFIEE-IRSKGDSVYVHCKAGRGRSATLVACYLM---
... | .....|.|.|..|        ..     .     . |.| . |.|  .. . | . ..|||. ...||  |.|||.|| ||..||||.|||   
rmlkelgittivmltelle......lgklkceqyi.....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylmllg

----------KSKRPHIRLASQQWSAVQQFHDYL
          ..|||..    .|.  ...|...|
vsleeavalvrekRpgavpnpgqlrflyefekll
0040438 (Phosphotyrosine protein) phosphatases II 61-175 1.8e-19 65.6 In-house 104-275 (317) alignment 
Range on Protein: 61-175
Range on HMM: 104-275/317.0
KLVEEENVRAVVTLNEEFETK---------------------HFCNTSEeWSEWGVKQLRLAT-----------------VDFGNAPSLDNLSEGVKFIE
..| |..|. .|.|.|..| .                     ..... |  ... . .|..                    |.|  ||.| | . .....
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

EIRSK-GDSVYVHCKAGRGRSATLVACYLM-------------------KSKRPHIRLASQQWSAVQQFHDYL
| ... |  | |||.|| ||..|..|.|||                   ...||..    .|.  . ... ..
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalley
0045450 (Phosphotyrosine protein) phosphatases II 61-171 3.8e-19 65.0 In-house 125-299 (307) alignment 
Range on Protein: 61-171
Range on HMM: 125-299/307.0
KLVEEENVRAVVTLNEEFETKH---------------------FCNTSEEWSEWGVKQLRLATV------------------DFGNAPSLDNLSEGVKFI
... |..|...|.|.|..| ..                      .   |..... | .|..                     |.|  ||.. | . .. .
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

EEIRS---KGDSVYVHCKAGRGRSATLVACYLMKSK----------------------RPHIRLASQQWSAVQQF
.....   ||  |.|||.|| ||..|..|.|||..                       ||..    .|.  ....
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea
0047943 (Phosphotyrosine protein) phosphatases II 61-168 1e-16 56.7 In-house 95-264 (273) alignment 
Range on Protein: 61-168
Range on HMM: 95-264/273.0
KLVEEENVRAVVTLNEEFETKH------FCNTSEE-WSEWGVKQLR---------------------------------LATVDFGNAPSLDNLSEGVKF
..| |.||| .|.|.|..| .       . .. .| . . |  . .                                 .   |.|  |||. | | ...
rmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefiel

IEEIRS---KGDSVYVHCKAGRGRSATLVACYLM-------------------KSKRPHIRLASQQWSAV
......   ..  |.|||.|| ||..|..|..|.                   .|.||..    .|.  .
vrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0036941 (Phosphotyrosine protein) phosphatases II 61-171 1.9e-16 55.7 In-house 96-272 (297) alignment 
Range on Protein: 61-171
Range on HMM: 96-272/297.0
KLVEEENVRAVVTLNEEFETKH------FCNTSEE---WSEWGVKQLRLAT-------------------------------VDFGNAPSldNLSEGVKF
..| |.||. .|.|.|..|         . .. .|     .. |. |.  .                                .  ..|.  . .. ..|
rmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe..spaslldf

IEEIRS------KGDSVYVHCKAGRGRSATLVACYLM----------------------KSKRPHIRLASQQWSAVQQF
||..|.      .|  |.|||.|| |||.|..|..||                      ...||..    .|.  . ..
ielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyea
0046845 (Phosphotyrosine protein) phosphatases II 61-170 2.1e-14 49.1 In-house 95-259 (284) alignment 
Range on Protein: 61-170
Range on HMM: 95-259/284.0
KLVEEENVRAVVTLNEEFETKHF---------------------CNTSEEWSEWGVKQLRLAT------------------VDFGNAPSLDNLSEGVKFI
..| |.||| .|.|.|..| ..                      .   |. . . |  |.|                     |.|  ||...| | ....
rmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlv

EEIRSK---GDSVYVHCKAGRGRSATLVACYLMKSK-------------RPHIRLASQQWSAVQQ
.|....   |  . |||.|| ||..|..|..|...                  || .| . .||.
rellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqt
0050432 (Phosphotyrosine protein) phosphatases II 62-164 2.2e-16 55.5 In-house 127-287 (308) alignment 
Range on Protein: 62-164
Range on HMM: 127-287/308.0
LVEEENVRAVVTLNEEFEtKHFCNTSEEWSEW---GVKQLRLATV--------------------------------------DFGNAPSLDNLSEGVKF
.| |.||| .|.|....| .   .  . | .    |...    ||                                      |.|  ||.. | . ...
mvweqnvrvIvmLtklve.ngrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflel

IEEIRsKGDSVYVHCKAGRGRSATLVACYLM-------------------KSKRPHIRLASQQ
... . .|  ..|||.|| ||..|..|..|.                   ...||.     .|
vrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeq
0051299 (Phosphotyrosine protein) phosphatases II 62-159 3.2e-15 51.8 In-house 111-269 (288) alignment 
Range on Protein: 62-159
Range on HMM: 111-269/288.0
LVEEENVRAVVTLNEEFETKH--------------------FCNTSEEWSEWGVKQLRLATV---------------------DFGNAPSLDNLSEGVKF
.| |.||| .|.|....| .                      .   |..... | .|..  .                     |.|  .|.. | . ...
mvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrl

IEEIRSK-GDSVYVHCKAGRGRSATLVACYLM-------------------KSKRPHIR
. . ... |  |.|||.|| ||..|..|..|.                   ...||.. 
vrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmv
DSPc Dual specificity phosphatase, catalytic domain 63-160 1.7e-17 58.6 Pfam-A 14-105 (133) alignment 
Range on Protein: 63-160
Range on HMM: 14-105/133.0
VEEENVRAVVTLNEEFETKhfcntsEEWSEWGVKQLRLATVDFGNAPSLDNLSEGVKFIEEIRSKGDSVYVHCKAGRGRSATLVACYLMKSKRPHIRL
 |. .. .|. . .| . .       . ..   ..||.   |. ..   . |.| |.|||....|| .|.|||.||  |||||...||||.|.  .. 
leklgitlvinvtkevpnn......naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslne
DSPc Dual specificity phosphatase, catalytic domain 63-160 1.7e-17 58.6 In-house 14-105 (133) alignment 
Range on Protein: 63-160
Range on HMM: 14-105/133.0
VEEENVRAVVTLNEEFETKhfcntsEEWSEWGVKQLRLATVDFGNAPSLDNLSEGVKFIEEIRSKGDSVYVHCKAGRGRSATLVACYLMKSKRPHIRL
 |. .. .|. . .| . .       . ..   ..||.   |. ..   . |.| |.|||....|| .|.|||.||  |||||...||||.|.  .. 
leklgitlvinvtkevpnn......naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslne
subfamily_CDC14_pd Subfamily CDC14 63-153 5.1e-12 40.3 In-house 208-288 (328) alignment 
Range on Protein: 63-153
Range on HMM: 208-288/328.0
VEEENVRAVVTLNEEfetkhfCNTSEEWSEWGVKQLRLATVDfGNAPSLDNLSEGVKFIEEIrsKGdSVYVHCKAGRGRSATLVACYLMKS
  ..||..|| ||..          ... . |..   |  .| |  ||   . . .. .|..  .| .. |||||| ||  ||.|||||| 
frknnvttvvrLnkk......lYdakkftdaGfdhkDlffiD.GstPsdaivkkfleiaeka..eG.aiavhCkaGLGrtGtLiacylmkh
subfamily_RNGTT_pd Subfamily RNGTT 66-166 1.2e-08 28.8 In-house 53-151 (189) alignment 
Range on Protein: 66-166
Range on HMM: 53-151/189.0
ENVRAVVTLNEefeTKHFCNTsEEWSEWGVKQLRLATVDFGNAPSLDNLSEGVKFIEEI--RSKGDSVYVHCKAGRGRSATLVACYLMKSKRPHIRLASQ
.... |. | .   |. . .. || .. |.|. .|..   |.||. .. .|  | .||   ..  . . |||. |  |.  |...||.. .   .. | .
vklglvidltn...tsryYdk.eelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaava

QWS
...
lFa
subfamily_PTPDC1_pd Subfamily PTPDC1 67-155 3.9e-12 41.0 In-house 46-141 (182) alignment 
Range on Protein: 67-155
Range on HMM: 46-141/182.0
NVRAVVTLNEEFE---------TKHFCNTSEEWSEWGVKQLRLATVDFGnAPSLDNLSEGVKFIEEIRSKGdSVYVHCKAGRGRSATLVACYLMKSKR
 ..||. |.|..|         .. |    |.. | |.    ..  |.| ..||... . || ..   ..|  | ||| ||.||   |.||||. .||
gikavinLqekgehasCGagleesGfsYdlealmeqgiyvynfgwkDyg.vasleriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyakr
DSPc_SM00195 69-153 7.2e-06 20.9 In-house 139-220 (263) alignment 
Range on Protein: 69-153
Range on HMM: 139-220/263.0
RavvtlnEEFETKHFCNTSEEW-SEWGVKQLRLATVDFGNAP-SLDNLSEGVKFIEEIRSK-GDSVYVHCKAGRGRSATLVACYLMKS
.      .|......  | |.   .  |.|.   .    ..| | ... | ...... .|.    . |||.|| ||..|.|.  .. |
k......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiils
PTPc_SM00194 69-153 7.2e-06 20.9 In-house 139-220 (263) alignment 
Range on Protein: 69-153
Range on HMM: 139-220/263.0
RavvtlnEEFETKHFCNTSEEW-SEWGVKQLRLATVDFGNAP-SLDNLSEGVKFIEEIRSK-GDSVYVHCKAGRGRSATLVACYLMKS
.      .|......  | |.   .  |.|.   .    ..| | ... | ...... .|.    . |||.|| ||..|.|.  .. |
k......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiils
0049772 (Phosphotyrosine protein) phosphatases II 72-175 6.7e-21 70.8 In-house 167-273 (314) alignment 
Range on Protein: 72-175
Range on HMM: 167-273/314.0
VtlneefetkHFCNTSEEWSEWGVKQLRLATVDfGNAPSLDNLSEGVKFIEEIrSKGDSVYVHCKAGRGRSAT-LVACYLMKSK--------------RP
            ..  | ....|.| ||. . | |.||.|. . | ..||||  .||  |.||||||.||..| .||.||||                ||
k.........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp

hIRLASQQWSAVQQFHDYL
 |.    ..   .|.  .|
.inpnpgfieqleqyefil
subfamily_MKPLT_pd Subfamily MKPLT 73-155 2.6e-08 27.6 In-house 41-126 (164) alignment 
Range on Protein: 73-155
Range on HMM: 41-126/164.0
TLNEEFETKHFCNTSEEWSEWGVKQLRLATVDFGNAP--SLD-NLSEGVKFIEEIRSKGDSVYVHCKAGRGRSATLVACYLMKSKR
.. .. ...| .| |.|  .   | .   .|.  . .   |   |    ||. .    |  |.|||  |. ||..    .|.|||.
kvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskg
subfamily_MKPLV_pd Subfamily MKPLV 73-155 2.6e-08 27.6 In-house 41-126 (164) alignment 
Range on Protein: 73-155
Range on HMM: 41-126/164.0
TLNEEFETKHFCNTSEEWSEWGVKQLRLATVDFGNAP--SLD-NLSEGVKFIEEIRSKGDSVYVHCKAGRGRSATLVACYLMKSKR
.. .. ...| .| |.|  .   | .   .|.  . .   |   |    ||. .    |  |.|||  |. ||..    .|.|||.
kvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskg
Y_phosphatase Protein-tyrosine phosphatase 75-154 1.8e-07 26.2 Pfam-A 113-196 (235) alignment 
Range on Protein: 75-154
Range on HMM: 113-196/235.0
NEEFETKHFCNTSEEWS--EWGVKQLRLATVDFGNAPslDNLSEGVKFIEEIRSKG----DSVYVHCKAGRGRSATLVACYLMKSK
..|. ....  ......  .  |||| . .    ..|  .. .. ...|......      .| |||.|| ||..|.||  .. ..
ekeytlrklelkkkkeesekrevkqlhytnWpdhgvp..espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq
Y_phosphatase Protein-tyrosine phosphatase 75-154 1.8e-07 26.2 In-house 113-196 (235) alignment 
Range on Protein: 75-154
Range on HMM: 113-196/235.0
NEEFETKHFCNTSEEWS--EWGVKQLRLATVDFGNAPslDNLSEGVKFIEEIRSKG----DSVYVHCKAGRGRSATLVACYLMKSK
..|. ....  ......  .  |||| . .    ..|  .. .. ...|......      .| |||.|| ||..|.||  .. ..
ekeytlrklelkkkkeesekrevkqlhytnWpdhgvp..espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq
subfamily_PTEN_pd Subfamily PTEN 77-157 2.5e-09 32.3 In-house 72-143 (184) alignment 
Range on Protein: 77-157
Range on HMM: 72-143/184.0
EFETKHFcntseewsewgVKQLRLATVDFGNAPSLDNLSEGVKFIEEIRSKG--DSVYVHCKAGRGRSATLVACYLMKSKRPH
....|.|            ...    .|  |.|.|. |.| |. ||.  ..     | ||||||.||. .|...||.||.  .
kydskkf...........dgrvavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllksllle
PTPlike_phytase Inositol hexakisphosphate 84-151 2.2e-07 25.6 Pfam-A 82-147 (149) alignment 
Range on Protein: 84-151
Range on HMM: 82-147/149.0
CNTSEEWSEWGVKQLRLATVDfGNAPSLDNLSEGVKFIEEIrSKGDSVYVHCKAGRGRSATLVACYLM
    |  ...|||  |..  |  .||. ... . |..|... .. ... ..|.|||||. | .... .
vyeeelaegfgvkYvRipitd.eqapeeedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadL
PTPlike_phytase Inositol hexakisphosphate 84-151 2.2e-07 25.6 In-house 82-147 (149) alignment 
Range on Protein: 84-151
Range on HMM: 82-147/149.0
CNTSEEWSEWGVKQLRLATVDfGNAPSLDNLSEGVKFIEEIrSKGDSVYVHCKAGRGRSATLVACYLM
    |  ...|||  |..  |  .||. ... . |..|... .. ... ..|.|||||. | .... .
vyeeelaegfgvkYvRipitd.eqapeeedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadL
subfamily_Laforin_pd Subfamily Laforin 90-153 1.3e-10 34.4 In-house 72-135 (183) alignment 
Range on Protein: 90-153
Range on HMM: 72-135/183.0
WSEWGVKQLRLATVDFGNAPSLDNLSEGVKFIEEIRSKGDSVYVHCKAGRGRSATLVACYLMKS
. | |.  . | | |.     ..|| ..| ..  .  ||  |||||.|| |||...|  .|.  
ykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyv
subfamily_DSP10_pd Subfamily DSP10 92-159 8.7e-14 45.7 In-house 56-123 (159) alignment 
Range on Protein: 92-159
Range on HMM: 56-123/159.0
EWGVKQLRLATVDFGNAPSLDNLSEGVKFIEEIRSKGDSVYVHCKAGRGRSATLVACYLMKSKRPHIR
| ..|  |.   | ..     .  | ..||||.|.|| .| |||.||  ||||.|  |||| ..  ..
eealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlsln
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 92-155 4.1e-07 23.5 In-house 53-118 (154) alignment 
Range on Protein: 92-155
Range on HMM: 53-118/154.0
EWGVKQLRLATVDFGNAPSLDNLSEGVKFIEEIR--SKGDSVYVHCKAGRGRSATLVACYLMKSKR
 . .. |.|   |  |   ...|.   .||..     . . | ||...|  |||.|.  |||....
gfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklk
subfamily_DSP6_pd Subfamily DSP6 95-155 6.6e-12 39.2 In-house 60-120 (158) alignment 
Range on Protein: 95-155
Range on HMM: 60-120/158.0
VKQLRLATVDFGNAPSLDNLSEGVKFIEEIRSKGDSVYVHCKAGRGRSATLVACYLMKSKR
.| |...  |  ..     . | ..||.| |||  .| ||| ||  || |.. .||||.. 
lkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlaylmkkla
subfamily_VSP_pd Subfamily VSP 95-155 3e-07 24.6 In-house 93-155 (212) alignment 
Range on Protein: 95-155
Range on HMM: 93-155/212.0
VKQLRLATVDFGNAPSLDNLSEGVKFIEEIRSKGD--SVYVHCKAGRGRSATLVACYLMKSKR
 ....  ..|  | |.|..|    | ..|  .|     . .||| |.||. |.| ..|..|. 
nnrvkriliddhnvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllasei
subfamily_DSP19_pd Subfamily DSP19 96-162 3.8e-14 47.3 In-house 57-123 (152) alignment 
Range on Protein: 96-162
Range on HMM: 57-123/152.0
KQLRLATVDFGNAPSLDNLSEGVKFIEEIRSKGDSVYVHCKAGRGRSATLVACYLMKSKRPHIRLAS
. | .  .|  ..  |. |.| ..|||| |||   |.|||.||. |||..|  ||||... ... | 
tylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleeal
subfamily_Slingshot_pd Subfamily Slingshot 97-155 3.3e-10 33.6 In-house 65-123 (169) alignment 
Range on Protein: 97-155
Range on HMM: 65-123/169.0
QLRLATVDFGNAPSLDNLSEGVKFIEEIRSKGDSVYVHCKAGRGRSATLVACYLMKSKR
 |..   |  ..  |..  |  ||||. ..|| .| |||| |  |||. |  | ||. .
ylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyg
subfamily_DSP3_pd Subfamily DSP3 100-161 6.5e-10 32.9 In-house 68-130 (162) alignment 
Range on Protein: 100-161
Range on HMM: 68-130/162.0
LATVDFGNAPSLDNLSEGVKFIEE-IRSKGDSVYVHCKAGRGRSATLVACYLMKSKRPHIRLA
|   |. ..      .. .|||.| . .|   |.|||..|  ||||||  ||| ...  .  |
levdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlvea
subfamily_DSP1_pd Subfamily DSP1 111-162 4.4e-12 40.4 In-house 78-129 (163) alignment 
Range on Protein: 111-162
Range on HMM: 78-129/163.0
LDNLSEGVKFIEEIRSKGDSVYVHCKAGRGRSATLVACYLMKSKRPHIRLAS
   ..| ..||.|...|.  |..||.||  ||.||.  ||||.|| ..  |.
slvfeeviefidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeaf
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 112-154 2.1e-07 24.2 In-house 64-106 (145) alignment 
Range on Protein: 112-154
Range on HMM: 64-106/145.0
DNLSEGVKFIEEIRSKGDSVYVHCKAGRGRSATLVACYLMKSK
. . |   ||.  . .|  |.||| ||  || |.   .|||  
qhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkyc
subfamily_MSG5_pd Subfamily MSG5 113-155 2.4e-07 24.0 In-house 84-126 (165) alignment 
Range on Protein: 113-155
Range on HMM: 84-126/165.0
NLSEGVKFIEEIRSKGDSVYVHCKAGRGRSATLVACYLMKSKR
.||.  . |   .||.. . |||. |  |||.|.  |.||   
dlsrltriihaatskrkkilvhcqcglsrsaslivayimkyyn
0048567 (Phosphotyrosine protein) phosphatases II 114-173 2.3e-12 41.5 In-house 53-136 (157) alignment 
Range on Protein: 114-173
Range on HMM: 53-136/157.0
LSEGV-------KFIEEIRSKGDSVYVHCKAGR---GRSATLVACYLMK--------------SKRPHIRLASQQWSAVQQFHD
|.  .       ||.. .. .|  ..||||||.   ||.|||..|||..                ||.. .  ... ..  .. 
lailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslynl
subfamily_LRR-DSP_pd Subfamily LRR-DSP 117-157 4.4e-09 29.8 In-house 187-226 (263) alignment 
Range on Protein: 117-157
Range on HMM: 187-226/263.0
GVKFIEEIRSKGdSVYVHCKAGRGRSATLVACYLMKSKRPH
   |||| | ||  | |||.||  ||.||| .|||| .| .
tnafieeGrkkG.GvlvhcraGvsrsstlvisylmkkqrlk
PTPc_DSPc_SM00012 118-155 4.1e-08 28.7 In-house 23-66 (105) alignment 
Range on Protein: 118-155
Range on HMM: 23-66/105.0
VKFIEEIRSKG------DSVYVHCKAGRGRSATLVACYLMKSKR
..........        .| |||.|| ||..|.|| ... .. 
lellravkknknksesskpvvVhCsaGvgRtgtfvaldillqql
subfamily_STYX_pd Subfamily STYX 118-153 2.1e-06 20.9 In-house 86-121 (166) alignment 
Range on Protein: 118-153
Range on HMM: 86-121/166.0
VKFIEEIRSKGDSVYVHCKAGRGRSATLVACYLMKS
 .||..  .||  | || .||  |||.|| .|.|..
kefiddslqkggkvlvhgnagisrsaalviayimet