Gene PTPMT1-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PTPMT1
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP019_AA protein Get Run
NvecP019_AA_100-253 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PTEN_1 81-253 1.6e-32 107.9 In-house 21-194 (196) alignment 
Range on Protein: 81-253
Range on HMM: 21-194/196.0
ARVLFFPSLLWIVATESRS--RrwfdRIDSTVILGALPFKSQ-TQKLIDENVKGVITLNEEFETkhLC--NSKQEWFAWGVTQLRLATVDFGnAPSFAQL
.. .. .....  .. ||.  .    .|| ....| |.. ..  . |  ... .|..|.||.|.   .   ...|.|. ||..|..   |.| |||...|
dltyitsriiamgkapsrpllq....eideglyrgslkdvaadldnlkedgitlvvnlseeeel..sgrsydleeffksgveylhfpieDhg.apslsel

LEGVKFIEDMRS---KGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLHQK
.. .| ... ..   .|  |.||||||.||| |.||.|||. ..|...||  ....|||.... | .. .|... . |...
fdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae
subfamily_PTPMT1_pd Subfamily PTPMT1 85-253 6.7e-76 248.5 In-house 1-171 (171) alignment 
Range on Protein: 85-253
Range on HMM: 1-171/171.0
FFPSLLWIVATESRSRR-WFDRIDSTVILGALPFKSQTQKLI-DENVKGVITLNEEFETKHLCNSKQEWFAWGVTQLRLATVDFGNAPSFAQLLEGVKFI
|.|.||. | .|..|.| |.||||.|||||||||.|....|| .||||.|..||||.|.|.|.||..||  .||.||.|||||| .||....|..||.||
fyPtllynvlvekaskrnwydriDdtvilGalPfrslikeLiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefi

EDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLHQK
|...|||..||||||||||||.|||||||||...|.||||. ..|.||..||||..|| |||.....|..|
ekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekllsk
0044763 (Phosphotyrosine protein) phosphatases II 89-254 2.2e-36 120.5 In-house 9-174 (178) alignment 
Range on Protein: 89-254
Range on HMM: 9-174/178.0
LLWIVATESRSRRWFDRIDSTVILGALPFKSQTQKLIDENVKGVITLNEEFETKHLCNSKQEWFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMR-S
| ..  .|.    ....|.  ..||.||  .  . | ..... ...|.||.|  .| . .. .   |.. |.. ..|.|. ......|| |.|||. . .
lsnleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealde

KGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPqIRLASQQWIALQQFHDHLHQKK
||  |.|||.||.|||.||||.||||  .|..|||  .....|| |     |.  |..|. .|....
kggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllkes
0046846 (Phosphotyrosine protein) phosphatases II 96-252 1.4e-37 124.4 In-house 5-174 (176) alignment 
Range on Protein: 96-252
Range on HMM: 5-174/176.0
ESRSRRWFDRIDSTVILGALP----------FKSQTQKLIDENVKGVITLNEEFETKHL--CNSKQEWFAWGVTQLRLATVDFGNAPSfAQLLEGVKFIE
..  . ..|.|.  .|||..|          . .  . | ..... |..|.||.|...|  .|  .|. . |.. |.| ..|.|  .. ..||| ..||.
llgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefir

DMRSKGDSVYVHCKAGRGRSTTLVACYLMKN-KNLNPEEAHLFIKSKRP-QIRLASQQWIALQQFHDHLHQ
.....|  |.|||.||.||. ||||.||..  |.|..|||  .....|| ..    .|.  |..|. .|..
ealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellllk
0041856 (Phosphotyrosine protein) phosphatases II 100-250 6.6e-29 96.2 In-house 16-170 (182) alignment 
Range on Protein: 100-250
Range on HMM: 16-170/182.0
RRWFDRIDSTVILGALPF--------------KSQTQKLIDENVKGVITLNeefetkHLCNSKQEWFAWGVTQLRLATVDFGNAPsfaqLLEGVKFIEDM
 |..|.|   ..||.||.               .  . | ..... ...|.        .   ...  .|.. |.|   |.|  .    | | ..|||..
srdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywpellerlgiqylylpwpDhgvpd....ldelldfieev

RSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHL
...|  |.|||.||.||. ||||.|||| .....|||  ...|.||..    .|.. ||..  .|
leeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallel
0048076 (Phosphotyrosine protein) phosphatases II 101-250 9.4e-32 105.0 In-house 2-142 (145) alignment 
Range on Protein: 101-250
Range on HMM: 2-142/145.0
RWFDRIDSTVILGALPFKSQTQKLIDENVKGVITLneefetkhlCNSKQEWFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGR
 |...|.  . || ||  .. . | | ... |..|         .. .. ... |.. |.| . |.|  .....||| ..|||. ...|  |.|||.||.
ywpseilpglylgslptaldlellkdlgittvlnl.........tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGv

GRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHL
||..||||.|||. .....|||  ...|.||..    .|.. |..|. .|
gRtgtlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 102-250 1.5e-31 104.5 In-house 3-144 (144) alignment 
Range on Protein: 102-250
Range on HMM: 3-144/144.0
WFDRIDSTVILGALPFKSQTQKLIDENVKGVITLNEEFETKHLCNSkqewfawGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRG
....|.. . || ||. .. . | . ... ||.|.||.|  .| .        |.. |.| . |.|  .....||| ..|||. ...|  |.|||.||.|
npseilpglylgslptaldlellkklgittvinlteeyepeflere.......giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvg

RSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHL
|..||||.|||| ..|..|||  ...|.||..    .|.. |......|
RtgtlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekll
0045098 (Phosphotyrosine protein) phosphatases II 102-253 1.5e-28 95.4 In-house 21-274 (278) alignment 
Range on Protein: 102-253
Range on HMM: 21-274/278.0
WFDRIDSTVILGALP-----------------------------------------FKSQTQKLIDENVKGVITLNEEFET-------------------
 ...|   . || |.                                         . .  . | ..... ...|.|..|                    
ipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygd

---------------------KHLCNSKQEWFAWGVTQLRLATVDFGNAPSFA---QLLEGVKFIEDMRS--------------KGDSVYVHCKAGRGRS
                      .|.. ....  .|||.| . ... ...||.    ..|| ..||.. ..              .|  |.|||.|| ||.
ftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRt

TTLVACYLMKNK---NLNPEEAHLFIKSKRPQ-IRLASQQWIALQQFHDHLHQK
 ||||.|||.     .....||  ...|.||. .    .|.. | .|. .|...
GtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0051082 (Phosphotyrosine protein) phosphatases II 102-242 2e-26 87.8 In-house 7-144 (151) alignment 
Range on Protein: 102-242
Range on HMM: 7-144/151.0
WFDRIDSTVILGALPFKSQTQKLIDENVKGVITLNEEFETKhlcNSKQEWFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSK-GDSVYVHCKAGR
.| .... ..... |   . . | ....| ...|..|.|..   . .. . ..|.. |..  .|. . .    . . ..|.| ...| .  |.|||.||.
nfsyvtgglyrsggpladflellkelgiktivnlrseeerg...ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGk

GRSTTLVACYLMKnKNLNPEEAHLFIKSKRPQIRLASQQWIA
||. ||||.|||.  ....|||  ....||| .   .||.. 
gRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflf
0043147 (Phosphotyrosine protein) phosphatases II 103-253 1.4e-30 101.7 In-house 19-163 (172) alignment 
Range on Protein: 103-253
Range on HMM: 19-163/172.0
FDRIDSTVILGALPFKSQTQKLIDENVKGVITLNEEfetkhlCNSKQEWFAWGVTQLRLATVDFGNApSFAQLLEGVKFIED--MRSKGDSVYVHCKAGR
 ||.  |  ..  .. .  . | ..... ...|.|.      .. ..  .  |.. |.|   |.|   ....||| ..||..   .|.|  |.|||.|| 
pdrfiatqgplrntladfwrmlkelgithivnltel......lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGv

GRSTTLVACYLMKnKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLHQK
||. ||||.|||. ..|..|||  ....|||..    .|.. |..|...|.. 
gRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklllll
0036282 (Phosphotyrosine protein) phosphatases II 103-251 1.1e-28 95.5 In-house 12-170 (174) alignment 
Range on Protein: 103-251
Range on HMM: 12-170/174.0
FDRIDSTVILGALPFKsQTQKLIDENVKGVITLNEEFETK-----HLCNS-KQEWFAWGVTQLRLATVDFGNAPSFAqLLEGVKFIEDMRSK--GDSVYV
. .| . .|.|. |..   . | ..... |..|.||.| .     ..... .. .   |.. |.| ..|.|  ..   ||| |||.|. .|.  |  |.|
lsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlV

HCKAGRGRSTTLVACYLMKNKNL-NPEEAHLFIKSKR---PQIRLASQQWIALQQFHDHLH
||.||.||. ||||.|||.   | ....|  .....|   |..    .|.. |..|.. |.
HCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfeklls
0037934 (Phosphotyrosine protein) phosphatases II 103-249 6.4e-25 83.5 In-house 39-240 (243) alignment 
Range on Protein: 103-249
Range on HMM: 39-240/243.0
FDRIDSTVILGALPFKS--------QTQKLIDENVKGVITLNEEFETKHL-----------------------------------CNSK-QEWFAWGVTQ
. ..  ..|.. .| ..          . | ..... ...|.|..| ...                                   .| . ....  ..  
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

LRLATVDFGNAPSFAQLLEGVKFIED---------MRSKGDSVYVHCKAGRGRSTTLVACYLMKNK-NLNPEEAHLFIKSKRPQ-IRLASQQWIALQQFH
..|.  |.|  .|...||. .... .          ...|  |.|||.||.||. ||.|.|||. . ....|||  .....||. .    .|.. |....
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal

DH
 .
le
0042113 (Phosphotyrosine protein) phosphatases II 104-247 3.9e-27 90.7 In-house 48-239 (245) alignment 
Range on Protein: 104-247
Range on HMM: 48-239/245.0
DRIDSTVILGALPFKSQTQ----KLIDENVKGVITLNEEFETKH-------------------------------------LCNSKQEWFAWGVTQLRLA
.||  ..|... | .. ..     | ..... ...|.||.| ..                                     . | .  .   ... ..| 
yritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylp

TVDFGNAPSFAQLLEGVKFIEDMRS--KGDSVYVHCKAGRGRSTTLVACYLM-----KNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFH
  |.| ... ..||. ..|... ..  ..  |.|||.||.||. |..|.|||     |......|||  ...|.||...   .|.. |....
wpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
subfamily_DSP12_pd Subfamily DSP12 104-237 2.3e-19 64.3 In-house 3-130 (155) alignment 
Range on Protein: 104-237
Range on HMM: 3-130/155.0
DRIDSTVILGALPFKSQTQKLIDENVKGVITLNEEFEtkhlCNSKQEWFAwgVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRS
.||.  . || |.   ....| . ... |... .|       . |...    |... .  .|  ... .  | | |.|||. ......|.|||.||  ||
srilpglylggleavqeeellkelkithvlsvikeel....pehklkkgk..vstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRS

TTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLAS
 |.|. ||||...|. |.|. ..|.|.|.|.   
vtiviAYlmkkeklslekAlklvkekkpeiepNe
0038934 (Phosphotyrosine protein) phosphatases II 105-251 7.7e-29 96.1 In-house 15-177 (194) alignment 
Range on Protein: 105-251
Range on HMM: 15-177/194.0
RIDSTVILGALPFKSQTQK------------------LIDENVKGVITLNEEfetkHLCNSKQEWFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMR
.|   .|  ..| ..  .|                  |  ...  ||.|...    . . ...|. . |.. |.| ..|.|..||...||. ....... 
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnt....eryYdpeefekagieylklpfpddgtvPsleillrfldlvdefl

SK--GDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLH
..  |  |.||||||.||. ||||.||..  ....|||  ....||| .    ... ||......| 
nedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelr
PTPc_motif_SM00404 105-247 2.2e-22 74.4 In-house 4-138 (140) alignment 
Range on Protein: 105-247
Range on HMM: 4-138/140.0
RIDSTVILGALPFKSQTQKLIDENVKGVITLNEEFETKhlcnskqeWFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRST
||   ..|| .. ... ..|   ... || . || . .            |.. |..   | .... ...| . ..|||....|| .|.|||.||  || 
rilphlylgskskaqnpallkklgithvinvteevslt........kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSa

TLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFH
||...|||. ..|. .||  |.|..||.|.   . .  |... 
tliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieye
subfamily_STYX_pd Subfamily STYX 105-240 3.6e-10 33.2 In-house 14-147 (166) alignment 
Range on Protein: 105-240
Range on HMM: 14-147/166.0
RIDSTVILGAL--PFKSQTQKLIDENVKGVITLNEEFETKHLCNSKQEWFAWGVTQLrlATVDFGNAPSFAQllEGVKFIEDMRSKGDSVYVHCKAGRGR
 |   . ||      ||. ..| .. .  .. . .. |.. .    .. | . | ..  |     |   .    .  .||.|  .||  | || .||  |
eilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldv..adntveniirylp..tvkefiddslqkggkvlvhgnagisr

STTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQW
|..|| .|.|.   |.  ||..... .|  |   .   
saalviayimetyglkyreafayvqerrfcinpnegfv
0039614 (Phosphotyrosine protein) phosphatases II 106-253 3e-25 84.7 In-house 99-291 (297) alignment 
Range on Protein: 106-253
Range on HMM: 99-291/297.0
IDSTVILGALPFKSQ----TQKLIDENVKGVITLNEEFETKHLC----------------NSKQEWFAWGVT--QL---------------RLATVDFGN
.. ..|.   | ..      . . ...|. ...|....| .. |                . ...    |.|  .|                .   |.| 
ltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgv

APSFAQLLEGVKFIEDMRS---KGDSVYVHCKAGRGRSTTLVACYLM-----KNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLHQK
 ||...||| ...... ..   ||  |.|||.|| ||. |..|.|||     |.......||  .....||...   .|.. |...  .| ..
ppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0049260 (Phosphotyrosine protein) phosphatases II 107-250 1.3e-28 94.9 In-house 12-149 (152) alignment 
Range on Protein: 107-250
Range on HMM: 12-149/152.0
DSTVILGALPFKSQTQKLIDENVKGVITLNEEFEtKHLCNSKQEWfawgvTQLRLATVDFGNAPSFAQLLEGVKFIED-MRSKGDSVYVHCKAGRGRSTT
  |  .|  ....  . | . ... ...|.|..| .. .  .| .     . |.| . |.|  ..   ||. ..|||   ..||  |.|||.|| ||. |
iatqgpgpntladfwrmlkelgittivmltelle.lgklkceqyi.....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgt

LVACYLMKnKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHL
|||.|||. .....|||  ....|||..    .|.. |..|...|
lvaaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
0045450 (Phosphotyrosine protein) phosphatases II 107-247 3.2e-24 81.6 In-house 106-300 (307) alignment 
Range on Protein: 107-247
Range on HMM: 106-300/307.0
DSTVILGALPFKSQT----QKLIDENVKGVITLNEEFETKH---------------------LCNSKQEWFAWGVTQLRLATV-----------------
. . |.   | ..      . | ...|. ...|.|..| ..                      . |....  . |..|..                    
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgw

-DFGNAPSFAQLLEGVKFIEDMRS---KGDSVYVHCKAGRGRSTTLVACYLMKNKN--------LNPEEAHLFIKSKRPQIRLASQQWIALQQFH
 |.|  |||..||. .. ......   ||  |.|||.|| ||. |..|.|||.           ....||  .....||..    .|.. |... 
pdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal
0043336 (Phosphotyrosine protein) phosphatases II 107-246 1.3e-21 72.7 In-house 87-272 (278) alignment 
Range on Protein: 107-246
Range on HMM: 87-272/278.0
DSTVILGALPFKSQ----TQKLIDENVKGVITLNEEFETKH----------------------------------LCNS--KQEWFAWGVTQLRLATVDF
  ..|.   | ..      . . ...|. ...|.|..| ..                                  |. .  .  .  ...    |.  |.
prkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdh

GNAPSFAQLLEGVKFIEDMRS-KGDSVYVHCKAGRGRSTTLVACYLM-----KNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQF
|  .|...||. .|.. .... ..  |.|||.|| ||. |..|.||.     |......|||  .....||..    .|.. | ..
gvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 107-236 1.8e-12 41.0 In-house 12-133 (148) alignment 
Range on Protein: 107-236
Range on HMM: 12-133/148.0
DSTVILGALPFKSQTQKLIDENVKGVITLNEefETKHLCNSKqewfawGVTQLRLATVDfGNAPSFAQLLEG-VKFIEDMRSKGDSVYVHCKAGRGRSTT
|. . ||. ..... ..| . .|  ... ..  | .   . .      |.  | .|  |  .     .. |  ..|.. ....|  | ||.. |. ||. 
dafLFlGskksaadlealkalgvtrivnatk..erdnaldqr......gieYlhvaldD.kpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssa

LVACYLMKNKNLNPEEAHLFIKSKRPQIRLA
|.  .|.. |.   .||  ..||||. ..  
lallwlidfkrvslkealalvkskrryvdpn
0040439 (Phosphotyrosine protein) phosphatases II 108-247 2.3e-22 75.3 In-house 54-242 (249) alignment 
Range on Protein: 108-247
Range on HMM: 54-242/249.0
STVILGALPFKSQT----QKLIDENVKGVITLNEEFETKH-LC--------------------------------------NSKQEWFAWGVTQLRLAtv
 ..|.   | .. .    . | ..... ...|....| ..  |                                        ...   ...  . .   
rrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..

DFGNAPSFAQLLEGVKFIEDMRS---KGDSVYVHCKAGRGRSTTLVACYLM-----KNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFH
|.|  |||..||. .. ......   ||  |.|||.|| ||. |..|.|||     |......|||  ...|.||..    .|.. |... 
dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeal
0051429 (Phosphotyrosine protein) phosphatases II 110-250 2.9e-19 65.2 In-house 24-224 (272) alignment 
Range on Protein: 110-250
Range on HMM: 24-224/272.0
VILGALP---FKSQTQKLIDENVKGVITLNEEFETKHlcnSKQEWFAWGVTQLRLATVDFGNAPSF----------------------------------
..... |      . ..| ....| ...| .|.| ..    | .... |.. |.| ..|..  . .                                  
lyrsggplpltaadfwrlkelgiktivdLrseeErgr...lkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagear

-----------------AQLLEGVKFIEDmrskGDSVYVHCKAGRGRSTTLVACYLMKnKNLN--------------PEEAHLFIKSKRPQIRLASQQWI
                  .||| .... |    |  |.|||.||..|. |.||..|.   ...              .|||   ....||...   .|..
evmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqyl

ALQQFHDHL
 |...  .|
flyeallel
0040438 (Phosphotyrosine protein) phosphatases II 111-254 5.6e-23 77.1 In-house 89-279 (317) alignment 
Range on Protein: 111-254
Range on HMM: 89-279/317.0
ILGALPFKSQT----QKLIDENVKGVITLNEEFETKH--------------------LCNSKQEwfAWGVTQLRLAT-------------------VDFG
|.   | .. .    . . ...|. ...|.|..| .                      . | .|    |.| ..|                      |.|
IatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee..lagitlrtlevedlgdsesrtvthfhytgWpdhg

NAPSFAQLLEGVKFIEDMRSK-GDSVYVHCKAGRGRSTTLVACYLM-----KNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLHQKK
  ||. .||. ...... ... |  | |||.|| ||. |..|.|||     |......|||  .....||..    .|.. | ... .....|
vppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
subfamily_DSP1_pd Subfamily DSP1 112-253 5.9e-17 56.2 In-house 27-159 (163) alignment 
Range on Protein: 112-253
Range on HMM: 27-159/163.0
LGALPFKSQTQKLIDENVKGVITLNEEfetkhLCNSKQEWFAWGVTQLRlatvDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYL
||.    |... | ....  .. . .|     | |  .. | .   .|.    |  .|   . . | ..||.....|.  |..||.||  ||.||.  ||
lGsetvasnleiLkslgitailnvske.....ldnvfedlfeYkklkle....DspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclayl

MKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLHQK
||.|... |||. |.|..|. |.        | ... .| ..
mktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkllle
subfamily_DSP15_pd Subfamily DSP15 112-232 2.8e-15 50.7 In-house 11-121 (151) alignment 
Range on Protein: 112-232
Range on HMM: 11-121/151.0
LGALPFKSQTQKLIDENVKGVITLNEefetkhlcnsKQEWFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYL
|| .   .....| ..|.  ......           .. .   .. . .|  |  .|     . | |.|| . |.|...|.||| ||  ||.|||. ||
lgnfrdskdeelLkeknithilsvhd..........nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MKNKNLNPEEAHLFIKSKRPQ
|   .|| ..|  .|| .|  
mtvtelnwrdalevikaaRsv
subfamily_DSP23_pd Subfamily DSP23 114-243 5.8e-17 56.7 In-house 16-138 (148) alignment 
Range on Protein: 114-243
Range on HMM: 16-138/148.0
ALPF-KSQTQKLIDENVKGVITLNEEfetkhlCNSKQEWfAWGVTQLRLATVDFgNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLM
|||   .| . |.|  |. ...| ||      .. . |  . ..|  ||   |.   |.  |. | |. .|.  .|...| |||  ||||. |..||||.
alprlpdqyrylldlgvrylvsltee......grphvea.tpnltlvrlriddy.hppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylv

KNKNLNPEEAHLFIKSKRPQIRLASQQWIAL
|...|   ||   .. .||    . .|  ..
kerklaaaeaiaevrrlrpgsvetveqeklv
subfamily_Laforin_pd Subfamily Laforin 119-244 1.4e-13 44.1 In-house 44-165 (183) alignment 
Range on Protein: 119-244
Range on HMM: 44-165/183.0
SQTQKLIDENVKGVITLNEEFeTKHLCNSKQEWfawGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLN
 ||.  | .|  |.   ||..  . | .  .|    |.. . | | |.       .| ..| ..  .  ||  |||||.|| ||||..|  .|.   . .
lqtesdivknssgiyrynenl.pitlkklykee...glayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgws

PEEAHLFIKSKRPQIRLASQQWIALQ
      |. .||| . .  .  |  .
lakvqyfllakrpvvyideealirae
DSPc Dual specificity phosphatase, catalytic domain 121-247 2e-21 71.2 Pfam-A 11-131 (133) alignment 
Range on Protein: 121-247
Range on HMM: 11-131/133.0
TQKLIDENVKGVITLNEEFETKHL-CNSKQEWFAWGVTQlrlatvdFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNP
 ..| . ... || . .| . ... ..|..| .   | .       . ..   ..| | |.|||....|| .|.|||.||  || ||...|||| |||. 
lalleklgitlvinvtkevpnnnaikkseieylripved.......etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlsl

EEAHLFIKSKRPQIRLASQQWIALQQFH
.||  |.|..|..|.   ...  | .. 
neAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 121-247 2e-21 71.2 In-house 11-131 (133) alignment 
Range on Protein: 121-247
Range on HMM: 11-131/133.0
TQKLIDENVKGVITLNEEFETKHL-CNSKQEWFAWGVTQlrlatvdFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNP
 ..| . ... || . .| . ... ..|..| .   | .       . ..   ..| | |.|||....|| .|.|||.||  || ||...|||| |||. 
lalleklgitlvinvtkevpnnnaikkseieylripved.......etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlsl

EEAHLFIKSKRPQIRLASQQWIALQQFH
.||  |.|..|..|.   ...  | .. 
neAyefvkerrskispnagflrqLleye
subfamily_STYXL1_pd Subfamily STYXL1 121-237 5e-12 39.3 In-house 28-140 (157) alignment 
Range on Protein: 121-237
Range on HMM: 28-140/157.0
TQKLI--DENVKGVITLNEefETKHLCNSKQEwfawGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLN
... |  |  ||... .    ....| .. ..     .  |..|  |  .|  . .| | |.|||. . .|. | |  . |  ||......||| .|...
qnpaikkdlkvkahvnvsm..dadkliagvad....vakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkit

PEEAHLFIKSKRPQIRLAS
 ..|. ..|  .. ..   
lkkaykylkkCkenvkPnr
0036941 (Phosphotyrosine protein) phosphatases II 122-253 1.4e-19 66.0 In-house 78-279 (297) alignment 
Range on Protein: 122-253
Range on HMM: 78-279/297.0
QKL------------------IDENVKGVITLNEEFETKH---------LCNSKQEWFAWGVTQLRLAT-------------------------------
.|                    ..||. ...|.|..|              .. ..   . || |.  .                               
rkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytg

-VDFGNAPSFAQLLEGVKFIEDMRS---KGDSVYVHCKAGRGRSTTLVACYLM--------KNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLH
  |.|  .|.|.||. .........   .|  |.|||.|| ||| |..|..||        |...... || ......||..    .|.. | ..  .| 
wpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

QK
.|
kk
subfamily_PTPDC1_pd Subfamily PTPDC1 122-255 1.1e-18 62.3 In-house 40-180 (182) alignment 
Range on Protein: 122-255
Range on HMM: 40-180/182.0
QKLIDENVKGVITLNEEFETKHLCNSK---------QEWFAWGVTQLRLATVDFGnAPSFAQLLEGVKFIEDMRSKGdSVYVHCKAGRGRSTTLVACYLM
.|.... .| || |.|..|  .  ...         ... . |..   ..  |.| ..|  ..|. || ..   ..|  | ||| ||.||   |.||||.
dkfkesgikavinLqekgehasCGagleesGfsYdlealmeqgiyvynfgwkDyg.vasleriLdivkvvafalqeg.kvavhChaGlGrtGvliacylv

KNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLHQKKN
 .|.|..|.|  ...||||.   . .|   ...|. .|.....
yakrltaekaiklvrskrpksiqtreqvelvkefalfliplrk
0047943 (Phosphotyrosine protein) phosphatases II 123-245 3.8e-19 64.7 In-house 96-266 (273) alignment 
Range on Protein: 123-245
Range on HMM: 96-266/273.0
KLIDENVKGVITLNEEFETKH-----------------------LCNSKQEWFAWGVTQLRLA-----------------TVDFGNAPSFAQLLEGVKFI
 . ..||. ...|.|..| .                         . | ..   . |..|.|                    |.|  ||...||| ....
mvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielv

EDMRS---KGDSVYVHCKAGRGRSTTLVACYLM-----KNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQ
.....   ..  |.|||.|| ||. |..|..|.     |.......||  ...|.|| .    .|.. | .
rkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflye
subfamily_CDC14_pd Subfamily CDC14 123-245 1.9e-14 48.3 In-house 207-320 (328) alignment 
Range on Protein: 123-245
Range on HMM: 207-320/328.0
KLIDENVKGVITLNEEfetkhlCNSKQEWFAWGVTQLRLATVDfGNAPSFAQLLEGVKFIEDMrskGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEA
   ..||. |. ||..         .... . |.    |  .| |  || | . . .. .|..     .. |||||| ||  ||.||||||. ... .||
yfrknnvttvvrLnkk......lYdakkftdaGfdhkDlffiD.GstPsdaivkkfleiaeka...eGaiavhCkaGLGrtGtLiacylmkhyrftaaea

HLFIKSKRPQIRLASQQ-WIALQQ
  ...  ||   .. || ..  .|
iawlricrPGsvigpqqkfleekq
0050432 (Phosphotyrosine protein) phosphatases II 124-245 4.3e-19 64.4 In-house 128-293 (308) alignment 
Range on Protein: 124-245
Range on HMM: 128-293/308.0
LIDENVKGVITLNEEFEtKHLCNSKQEWFAW---GVTQLRLATV--------------------------------------DFGNAPSFAQLLEGVKFI
. ..||. ...|....| .   .  | |      |...    ||                                      |.|  ||...||. ....
vweqnvrvIvmLtklve.ngrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelv

EDMRsKGDSVYVHCKAGRGRSTTLVACYLM-----KNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQ
.... .|  ..|||.|| ||. |..|..|.     |.......||  .....||.     .| . | .
rksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyr
0051299 (Phosphotyrosine protein) phosphatases II 124-242 2.3e-17 58.9 In-house 112-277 (288) alignment 
Range on Protein: 124-242
Range on HMM: 112-277/288.0
LIDENVKGVITLNEEFETKH--------------------LCNSKQEWFAWGVTQLRLATV---------------------DFGNAPSFAQLLEGVKFI
. ..||. ...|....| .                      . | ...  . |..|..  .                     |.|  .|. .||. ....
vweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlv

EDMRSK-GDSVYVHCKAGRGRSTTLVACYLM-----KNKNLNPEEAHLFIKSKRPQIRLASQQWIA
 ..... |  |.|||.|| ||. |..|..|.     |.. ....||  .....||..    .| . 
rkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrf
0046845 (Phosphotyrosine protein) phosphatases II 124-246 1.1e-15 53.2 In-house 97-269 (284) alignment 
Range on Protein: 124-246
Range on HMM: 97-269/284.0
LIDENVKGVITLNEEFETKHL---------------------CNSKQEWFAWGVTQLRLAT------------------VDFGNAPSFAQLLEGVKFIED
. ..||. ...|.|..| ..                      . |...   . |. |.|                     |.|  ||...||| ......
vweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvre

MRSK---GDSVYVHCKAGRGRSTTLVACYLMKNK--------NLNPEEAHLFIKSKRPQIRLASQQWIALQQF
....   |  . |||.|| ||. |..|..|...         .....||  .....||.     .| . . ..
llenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyea
subfamily_MKPLT_pd Subfamily MKPLT 135-247 1.1e-10 35.3 In-house 42-157 (164) alignment 
Range on Protein: 135-247
Range on HMM: 42-157/164.0
LNEEFETKHLCNSKQE---WFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRP
. .. ...| .|  ||    |.  |  |.. . |  .    . |    ||. |    |  |.|||  |. ||..    .|.| |    .||. ..| .| 
vlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrs

QIRLASQQWIALQQFH
 ..      . | .| 
ivapnrGflkqlakfe
subfamily_MKPLV_pd Subfamily MKPLV 135-247 1.1e-10 35.3 In-house 42-157 (164) alignment 
Range on Protein: 135-247
Range on HMM: 42-157/164.0
LNEEFETKHLCNSKQE---WFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRP
. .. ...| .|  ||    |.  |  |.. . |  .    . |    ||. |    |  |.|||  |. ||..    .|.| |    .||. ..| .| 
vlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrs

QIRLASQQWIALQQFH
 ..      . | .| 
ivapnrGflkqlakfe
0049772 (Phosphotyrosine protein) phosphatases II 143-253 6.1e-27 90.6 In-house 168-276 (314) alignment 
Range on Protein: 143-253
Range on HMM: 168-276/314.0
HLCNSKQEWFAWGVTQLRLATVDfGNAPSFAQLLEGVKFIEDMrSKGDSVYVHCKAGRGRSTT-LVACYLMKNKNLNPEEAHLFIKSKRPqIRLASQQWI
  ..... .  .|.. ||. . | |.||......| ..|||.  .||  |.||||||.||..| .||.||||  ....|||  ....||| |.    .. 
eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfie

ALQQFHDHLHQK
 |.|.  .|...
qleqyefileal
subfamily_VSP_pd Subfamily VSP 143-230 1.7e-07 25.3 In-house 80-170 (212) alignment 
Range on Protein: 143-230
Range on HMM: 80-170/212.0
HLCNSKQEWFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGD--SVYVHCKAGRGRSTTLVACYLMKNKNLNP-EEAHLFIKSKR
 ||  ..   ..   ...  ..|  | |.. .||   | .... .|     . .||| |.||. |.| ..|.. . ..  .|.  .. ..|
nlcseraydekyfnnrvkriliddhnvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerr
subfamily_CDKN3_pd Subfamily CDKN3 143-230 5.9e-06 20.0 In-house 87-174 (202) alignment 
Range on Protein: 143-230
Range on HMM: 87-174/202.0
HLCNSKQEWFAWGVTQLRLaTVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYL-MKNKNLNPEEAHLFIKSKR
 . .  ...   |..      .  | .|. |. |. .. .     ..    |||  | |||. ..|| | . .  ..|..|   ..  .
rvrrlldlyqqaglivhhy.piadglvpdiasclkileelrinlkayrktlvhcygglgrsslviaclllylddtiepkdaidklrdlk
subfamily_RNGTT_pd Subfamily RNGTT 147-233 2.1e-07 24.8 In-house 69-158 (189) alignment 
Range on Protein: 147-233
Range on HMM: 69-158/189.0
SKQEWFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDM--RSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEA-HLFIKSKRPQI
 |.|    |... .|..   |.||.  |  |  | .|.   ..  . . |||. |  |.  |...||..... . |.| .|| |.. | |
dkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGi
subfamily_DSP19_pd Subfamily DSP19 149-237 1.7e-17 58.2 In-house 49-137 (152) alignment 
Range on Protein: 149-237
Range on HMM: 49-137/152.0
QEWFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLAS
.. |.  .| | .  .|  ..   ..| | ..|||. |||   |.|||.||. ||...|  ||||...|. |||   ....|| |.  .
pnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpcikPne
subfamily_Slingshot_pd Subfamily Slingshot 151-254 6.5e-14 45.7 In-house 58-161 (169) alignment 
Range on Protein: 151-254
Range on HMM: 58-161/169.0
WFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHL
.|.  .. |..   |  ..  ...  |  ||||  ..|| .| |||| |  ||.. |  | ||. .|. |||. ..|..|  |.  .  .  |....  |
ffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGil

HQKK
. .|
eask
PTPlike_phytase Inositol hexakisphosphate 152-212 5.1e-08 27.7 Pfam-A 89-147 (149) alignment 
Range on Protein: 152-212
Range on HMM: 89-147/149.0
FAWGVTQLRLATVDfGNAPSFAQLLEGVKFIEDMrSKGDSVYVHCKAGRGRSTTLVACYLM
  .||.  |..  |  .||..... . |..|... .. ... ..|.|||||.|| .... .
egfgvkYvRipitd.eqapeeedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadL
PTPlike_phytase Inositol hexakisphosphate 152-212 5.1e-08 27.7 In-house 89-147 (149) alignment 
Range on Protein: 152-212
Range on HMM: 89-147/149.0
FAWGVTQLRLATVDfGNAPSFAQLLEGVKFIEDMrSKGDSVYVHCKAGRGRSTTLVACYLM
  .||.  |..  |  .||..... . |..|... .. ... ..|.|||||.|| .... .
egfgvkYvRipitd.eqapeeedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadL
subfamily_DSP14_pd Subfamily DSP14 155-254 3e-17 57.0 In-house 49-148 (157) alignment 
Range on Protein: 155-254
Range on HMM: 49-148/157.0
GVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLHQKK
.. .....  |  .|   . . | .. ||... ||  . |||.||. || .|.  |||| ..|. .||.  .||.||.||  .  |  |...  .|..|.
diervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgks
Y_phosphatase Protein-tyrosine phosphatase 155-230 9.7e-07 23.8 Pfam-A 134-216 (235) alignment 
Range on Protein: 155-230
Range on HMM: 134-216/235.0
GVTQLRLATVDFGNAP-SFAQLLegvKFIEDMRSKG----DSVYVHCKAGRGRSTTLVACYLMKNKNLN-----PEEAHLFIKSKR
 |.|| . .    ..| |  .||   ..|......      .| |||.|| ||. |.||  .. ..  .       ..   ....|
evkqlhytnWpdhgvpespksll...dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqR
Y_phosphatase Protein-tyrosine phosphatase 155-230 9.7e-07 23.8 In-house 134-216 (235) alignment 
Range on Protein: 155-230
Range on HMM: 134-216/235.0
GVTQLRLATVDFGNAP-SFAQLLegvKFIEDMRSKG----DSVYVHCKAGRGRSTTLVACYLMKNKNLN-----PEEAHLFIKSKR
 |.|| . .    ..| |  .||   ..|......      .| |||.|| ||. |.||  .. ..  .       ..   ....|
evkqlhytnWpdhgvpespksll...dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqR
subfamily_PTEN_pd Subfamily PTEN 163-232 1.1e-09 33.5 In-house 86-158 (184) alignment 
Range on Protein: 163-232
Range on HMM: 86-158/184.0
TVDFGNAPSFAQLLEGVKFIEDMRSK--GDSVYVHCKAGRGRSTTLVACYLMKNKNLNPE-EAHLFIKSKRPQ
 .|  |.|..  | | |. ||.  ..     | ||||||.||. .|...||.|.. |. . ||  . ...| .
pfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtk
PTPc_DSPc_SM00012 172-220 2e-08 29.7 In-house 22-70 (105) alignment 
Range on Protein: 172-220
Range on HMM: 22-70/105.0
FAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPE
. .||. ||  .  .... .| |||.|| ||. |.|| ... ... . .
ilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket
subfamily_DSP6_pd Subfamily DSP6 173-250 6.5e-15 49.0 In-house 77-154 (158) alignment 
Range on Protein: 173-250
Range on HMM: 77-154/158.0
AQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHL
. . | ..||.. |||  .| ||| ||  || |.. .||||...|  ..|. ..|.....|    .    | .|  .|
kffPeaiefidearskkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 173-221 3e-06 21.5 In-house 193-241 (307) alignment 
Range on Protein: 173-221
Range on HMM: 193-241/307.0
AQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEE
   |  . ..| .| . . | ||| || ||| |.||  |...| .. ..
qinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGin
subfamily_DSP10_pd Subfamily DSP10 176-236 7.9e-18 58.8 In-house 79-139 (159) alignment 
Range on Protein: 176-236
Range on HMM: 79-139/159.0
LEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLA
 | ..|||..|.|| .| |||.||  ||.|.|  ||||..||. ..|. |.|.||| |   
eealefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpiisPn
subfamily_DSP8_pd Subfamily DSP8 177-251 1e-15 51.7 In-house 81-155 (159) alignment 
Range on Protein: 177-251
Range on HMM: 81-155/159.0
EGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLH
. |.||. ..|.  .| ||. ||. ||.|.. .|.||. ... .||. |.|.||| |    .    | ... .|.
ksvefidkaksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelk
subfamily_DSP3_pd Subfamily DSP3 177-231 6.5e-11 36.1 In-house 84-139 (162) alignment 
Range on Protein: 177-231
Range on HMM: 84-139/162.0
EGVKFIED-MRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRP
. .|||.. . .|   |.|||..|  ||.|||  |||  ....  ||   ...|| 
taakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkRe
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 177-253 2e-09 30.7 In-house 68-144 (145) alignment 
Range on Protein: 177-253
Range on HMM: 68-144/145.0
EGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLHQK
|   ||.  . .|  |.||| ||  || |.   .|||  |.   ||   ..|.| .     .   .| ...  |...
evtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekqlkee
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 178-235 1.1e-08 28.6 In-house 78-137 (154) alignment 
Range on Protein: 178-235
Range on HMM: 78-137/154.0
GVKFIEDMR--SKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRL
  .||.|     . . | ||...|  ||..|.  |||......  .|  ..|. |..|. 
afefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryiikP
0048567 (Phosphotyrosine protein) phosphatases II 179-249 4.7e-17 56.7 In-house 64-137 (157) alignment 
Range on Protein: 179-249
Range on HMM: 64-137/157.0
VKFIEDMRSKGDSVYVHCKAGR---GRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDH
 ||..... .|  ..||||||.   ||. ||..|||..  ...||||  ...  || . .  ... .|  .. .
nkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslynlt
subfamily_LRR-DSP_pd Subfamily LRR-DSP 180-246 2.3e-12 40.6 In-house 189-254 (263) alignment 
Range on Protein: 180-246
Range on HMM: 189-254/263.0
KFIEDMRSKGdSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQF
 |||. | ||  | |||.||  ||.||| .||||...|. .||  ....|||.|.        |...
afieeGrkkG.GvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkky
subfamily_MSG5_pd Subfamily MSG5 180-234 3e-08 26.9 In-house 90-144 (165) alignment 
Range on Protein: 180-234
Range on HMM: 90-144/165.0
KFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIR
. |   .||.. . |||. |  ||..|.  |.||  ||  ..|.  .||.  .| 
riihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddis
subfamily_PRL_pd Subfamily PRL 186-247 1.6e-07 25.5 In-house 87-146 (151) alignment 
Range on Protein: 186-247
Range on HMM: 87-146/151.0
RSKGDSVYVHCKAGRGRSTTLVACYLMKnKNLNPEEAHLFIKSKRPQiRLASQQWIALQQFH
.. . .| ||| || ||.  |||  |.  . ...|.|  ||..||    . |.|   |....
eepkstvavhcvaGlGraPvlvalalie.aGmkyedavefirekrrg.ainskqlkflekyk