Gene PTPMT1-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PTPMT1
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP019_AA protein Get Run
NvecP019_AA_100-253 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PTEN_1 81-253 1.6e-32 107.9 In-house 21-194 (196) alignment
Range on Protein: 81-253
Range on HMM: 21-194/196.0
ARVLFFPSLLWIVATESRS--RrwfdRIDSTVILGALPFKSQ-TQKLIDENVKGVITLNEEFETkhLC--NSKQEWFAWGVTQLRLATVDFGnAPSFAQL
.. .. .....  .. ||.  .    .|| ....| |.. ..  . |  ... .|..|.||.|.   .   ...|.|. ||..|..   |.| |||...|
dltyitsriiamgkapsrpllq....eideglyrgslkdvaadldnlkedgitlvvnlseeeel..sgrsydleeffksgveylhfpieDhg.apslsel

LEGVKFIEDMRS---KGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLHQK
.. .| ... ..   .|  |.||||||.||| |.||.|||. ..|...||  ....|||.... | .. .|... . |...
fdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae

subfamily_PTPMT1_pd Subfamily PTPMT1 85-253 6.7e-76 248.5 In-house 1-171 (171) alignment
Range on Protein: 85-253
Range on HMM: 1-171/171.0
FFPSLLWIVATESRSRR-WFDRIDSTVILGALPFKSQTQKLI-DENVKGVITLNEEFETKHLCNSKQEWFAWGVTQLRLATVDFGNAPSFAQLLEGVKFI
|.|.||. | .|..|.| |.||||.|||||||||.|....|| .||||.|..||||.|.|.|.||..||  .||.||.|||||| .||....|..||.||
fyPtllynvlvekaskrnwydriDdtvilGalPfrslikeLiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefi

EDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLHQK
|...|||..||||||||||||.|||||||||...|.||||. ..|.||..||||..|| |||.....|..|
ekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekllsk

0044763 (Phosphotyrosine protein) phosphatases II 89-254 2.2e-36 120.5 In-house 9-174 (178) alignment
Range on Protein: 89-254
Range on HMM: 9-174/178.0
LLWIVATESRSRRWFDRIDSTVILGALPFKSQTQKLIDENVKGVITLNEEFETKHLCNSKQEWFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMR-S
| ..  .|.    ....|.  ..||.||  .  . | ..... ...|.||.|  .| . .. .   |.. |.. ..|.|. ......|| |.|||. . .
lsnleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealde

KGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPqIRLASQQWIALQQFHDHLHQKK
||  |.|||.||.|||.||||.||||  .|..|||  .....|| |     |.  |..|. .|....
kggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllkes

0046846 (Phosphotyrosine protein) phosphatases II 96-252 1.4e-37 124.4 In-house 5-174 (176) alignment
Range on Protein: 96-252
Range on HMM: 5-174/176.0
ESRSRRWFDRIDSTVILGALP----------FKSQTQKLIDENVKGVITLNEEFETKHL--CNSKQEWFAWGVTQLRLATVDFGNAPSfAQLLEGVKFIE
..  . ..|.|.  .|||..|          . .  . | ..... |..|.||.|...|  .|  .|. . |.. |.| ..|.|  .. ..||| ..||.
llgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefir

DMRSKGDSVYVHCKAGRGRSTTLVACYLMKN-KNLNPEEAHLFIKSKRP-QIRLASQQWIALQQFHDHLHQ
.....|  |.|||.||.||. ||||.||..  |.|..|||  .....|| ..    .|.  |..|. .|..
ealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellllk

0041856 (Phosphotyrosine protein) phosphatases II 100-250 6.6e-29 96.2 In-house 16-170 (182) alignment
Range on Protein: 100-250
Range on HMM: 16-170/182.0
RRWFDRIDSTVILGALPF--------------KSQTQKLIDENVKGVITLNeefetkHLCNSKQEWFAWGVTQLRLATVDFGNAPsfaqLLEGVKFIEDM
 |..|.|   ..||.||.               .  . | ..... ...|.        .   ...  .|.. |.|   |.|  .    | | ..|||..
srdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywpellerlgiqylylpwpDhgvpd....ldelldfieev

RSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHL
...|  |.|||.||.||. ||||.|||| .....|||  ...|.||..    .|.. ||..  .|
leeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallel

0048076 (Phosphotyrosine protein) phosphatases II 101-250 9.4e-32 105.0 In-house 2-142 (145) alignment
Range on Protein: 101-250
Range on HMM: 2-142/145.0
RWFDRIDSTVILGALPFKSQTQKLIDENVKGVITLneefetkhlCNSKQEWFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGR
 |...|.  . || ||  .. . | | ... |..|         .. .. ... |.. |.| . |.|  .....||| ..|||. ...|  |.|||.||.
ywpseilpglylgslptaldlellkdlgittvlnl.........tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGv

GRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHL
||..||||.|||. .....|||  ...|.||..    .|.. |..|. .|
gRtgtlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel

0048179 (Phosphotyrosine protein) phosphatases II 102-250 1.5e-31 104.5 In-house 3-144 (144) alignment
Range on Protein: 102-250
Range on HMM: 3-144/144.0
WFDRIDSTVILGALPFKSQTQKLIDENVKGVITLNEEFETKHLCNSkqewfawGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRG
....|.. . || ||. .. . | . ... ||.|.||.|  .| .        |.. |.| . |.|  .....||| ..|||. ...|  |.|||.||.|
npseilpglylgslptaldlellkklgittvinlteeyepeflere.......giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvg

RSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHL
|..||||.|||| ..|..|||  ...|.||..    .|.. |......|
RtgtlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekll

0045098 (Phosphotyrosine protein) phosphatases II 102-253 1.5e-28 95.4 In-house 21-274 (278) alignment
Range on Protein: 102-253
Range on HMM: 21-274/278.0
WFDRIDSTVILGALP-----------------------------------------FKSQTQKLIDENVKGVITLNEEFET-------------------
 ...|   . || |.                                         . .  . | ..... ...|.|..|                    
ipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygd

---------------------KHLCNSKQEWFAWGVTQLRLATVDFGNAPSFA---QLLEGVKFIEDMRS--------------KGDSVYVHCKAGRGRS
                      .|.. ....  .|||.| . ... ...||.    ..|| ..||.. ..              .|  |.|||.|| ||.
ftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRt

TTLVACYLMKNK---NLNPEEAHLFIKSKRPQ-IRLASQQWIALQQFHDHLHQK
 ||||.|||.     .....||  ...|.||. .    .|.. | .|. .|...
GtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelllr

0051082 (Phosphotyrosine protein) phosphatases II 102-242 2e-26 87.8 In-house 7-144 (151) alignment
Range on Protein: 102-242
Range on HMM: 7-144/151.0
WFDRIDSTVILGALPFKSQTQKLIDENVKGVITLNEEFETKhlcNSKQEWFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSK-GDSVYVHCKAGR
.| .... ..... |   . . | ....| ...|..|.|..   . .. . ..|.. |..  .|. . .    . . ..|.| ...| .  |.|||.||.
nfsyvtgglyrsggpladflellkelgiktivnlrseeerg...ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGk

GRSTTLVACYLMKnKNLNPEEAHLFIKSKRPQIRLASQQWIA
||. ||||.|||.  ....|||  ....||| .   .||.. 
gRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflf

0043147 (Phosphotyrosine protein) phosphatases II 103-253 1.4e-30 101.7 In-house 19-163 (172) alignment
Range on Protein: 103-253
Range on HMM: 19-163/172.0
FDRIDSTVILGALPFKSQTQKLIDENVKGVITLNEEfetkhlCNSKQEWFAWGVTQLRLATVDFGNApSFAQLLEGVKFIED--MRSKGDSVYVHCKAGR
 ||.  |  ..  .. .  . | ..... ...|.|.      .. ..  .  |.. |.|   |.|   ....||| ..||..   .|.|  |.|||.|| 
pdrfiatqgplrntladfwrmlkelgithivnltel......lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGv

GRSTTLVACYLMKnKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLHQK
||. ||||.|||. ..|..|||  ....|||..    .|.. |..|...|.. 
gRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklllll

0036282 (Phosphotyrosine protein) phosphatases II 103-251 1.1e-28 95.5 In-house 12-170 (174) alignment
Range on Protein: 103-251
Range on HMM: 12-170/174.0
FDRIDSTVILGALPFKsQTQKLIDENVKGVITLNEEFETK-----HLCNS-KQEWFAWGVTQLRLATVDFGNAPSFAqLLEGVKFIEDMRSK--GDSVYV
. .| . .|.|. |..   . | ..... |..|.||.| .     ..... .. .   |.. |.| ..|.|  ..   ||| |||.|. .|.  |  |.|
lsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlV

HCKAGRGRSTTLVACYLMKNKNL-NPEEAHLFIKSKR---PQIRLASQQWIALQQFHDHLH
||.||.||. ||||.|||.   | ....|  .....|   |..    .|.. |..|.. |.
HCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfeklls

0037934 (Phosphotyrosine protein) phosphatases II 103-249 6.4e-25 83.5 In-house 39-240 (243) alignment
Range on Protein: 103-249
Range on HMM: 39-240/243.0
FDRIDSTVILGALPFKS--------QTQKLIDENVKGVITLNEEFETKHL-----------------------------------CNSK-QEWFAWGVTQ
. ..  ..|.. .| ..          . | ..... ...|.|..| ...                                   .| . ....  ..  
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

LRLATVDFGNAPSFAQLLEGVKFIED---------MRSKGDSVYVHCKAGRGRSTTLVACYLMKNK-NLNPEEAHLFIKSKRPQ-IRLASQQWIALQQFH
..|.  |.|  .|...||. .... .          ...|  |.|||.||.||. ||.|.|||. . ....|||  .....||. .    .|.. |....
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal

DH
 .
le

0042113 (Phosphotyrosine protein) phosphatases II 104-247 3.9e-27 90.7 In-house 48-239 (245) alignment
Range on Protein: 104-247
Range on HMM: 48-239/245.0
DRIDSTVILGALPFKSQTQ----KLIDENVKGVITLNEEFETKH-------------------------------------LCNSKQEWFAWGVTQLRLA
.||  ..|... | .. ..     | ..... ...|.||.| ..                                     . | .  .   ... ..| 
yritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylp

TVDFGNAPSFAQLLEGVKFIEDMRS--KGDSVYVHCKAGRGRSTTLVACYLM-----KNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFH
  |.| ... ..||. ..|... ..  ..  |.|||.||.||. |..|.|||     |......|||  ...|.||...   .|.. |....
wpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal

subfamily_DSP12_pd Subfamily DSP12 104-237 2.3e-19 64.3 In-house 3-130 (155) alignment
Range on Protein: 104-237
Range on HMM: 3-130/155.0
DRIDSTVILGALPFKSQTQKLIDENVKGVITLNEEFEtkhlCNSKQEWFAwgVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRS
.||.  . || |.   ....| . ... |... .|       . |...    |... .  .|  ... .  | | |.|||. ......|.|||.||  ||
srilpglylggleavqeeellkelkithvlsvikeel....pehklkkgk..vstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRS

TTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLAS
 |.|. ||||...|. |.|. ..|.|.|.|.   
vtiviAYlmkkeklslekAlklvkekkpeiepNe

0038934 (Phosphotyrosine protein) phosphatases II 105-251 7.7e-29 96.1 In-house 15-177 (194) alignment
Range on Protein: 105-251
Range on HMM: 15-177/194.0
RIDSTVILGALPFKSQTQK------------------LIDENVKGVITLNEEfetkHLCNSKQEWFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMR
.|   .|  ..| ..  .|                  |  ...  ||.|...    . . ...|. . |.. |.| ..|.|..||...||. ....... 
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnt....eryYdpeefekagieylklpfpddgtvPsleillrfldlvdefl

SK--GDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLH
..  |  |.||||||.||. ||||.||..  ....|||  ....||| .    ... ||......| 
nedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelr

PTPc_motif_SM00404 105-247 2.2e-22 74.4 In-house 4-138 (140) alignment
Range on Protein: 105-247
Range on HMM: 4-138/140.0
RIDSTVILGALPFKSQTQKLIDENVKGVITLNEEFETKhlcnskqeWFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRST
||   ..|| .. ... ..|   ... || . || . .            |.. |..   | .... ...| . ..|||....|| .|.|||.||  || 
rilphlylgskskaqnpallkklgithvinvteevslt........kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSa

TLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFH
||...|||. ..|. .||  |.|..||.|.   . .  |... 
tliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieye

subfamily_STYX_pd Subfamily STYX 105-240 3.6e-10 33.2 In-house 14-147 (166) alignment
Range on Protein: 105-240
Range on HMM: 14-147/166.0
RIDSTVILGAL--PFKSQTQKLIDENVKGVITLNEEFETKHLCNSKQEWFAWGVTQLrlATVDFGNAPSFAQllEGVKFIEDMRSKGDSVYVHCKAGRGR
 |   . ||      ||. ..| .. .  .. . .. |.. .    .. | . | ..  |     |   .    .  .||.|  .||  | || .||  |
eilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldv..adntveniirylp..tvkefiddslqkggkvlvhgnagisr

STTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQW
|..|| .|.|.   |.  ||..... .|  |   .   
saalviayimetyglkyreafayvqerrfcinpnegfv

0039614 (Phosphotyrosine protein) phosphatases II 106-253 3e-25 84.7 In-house 99-291 (297) alignment
Range on Protein: 106-253
Range on HMM: 99-291/297.0
IDSTVILGALPFKSQ----TQKLIDENVKGVITLNEEFETKHLC----------------NSKQEWFAWGVT--QL---------------RLATVDFGN
.. ..|.   | ..      . . ...|. ...|....| .. |                . ...    |.|  .|                .   |.| 
ltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgv

APSFAQLLEGVKFIEDMRS---KGDSVYVHCKAGRGRSTTLVACYLM-----KNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLHQK
 ||...||| ...... ..   ||  |.|||.|| ||. |..|.|||     |.......||  .....||...   .|.. |...  .| ..
ppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr

0049260 (Phosphotyrosine protein) phosphatases II 107-250 1.3e-28 94.9 In-house 12-149 (152) alignment
Range on Protein: 107-250
Range on HMM: 12-149/152.0
DSTVILGALPFKSQTQKLIDENVKGVITLNEEFEtKHLCNSKQEWfawgvTQLRLATVDFGNAPSFAQLLEGVKFIED-MRSKGDSVYVHCKAGRGRSTT
  |  .|  ....  . | . ... ...|.|..| .. .  .| .     . |.| . |.|  ..   ||. ..|||   ..||  |.|||.|| ||. |
iatqgpgpntladfwrmlkelgittivmltelle.lgklkceqyi.....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgt

LVACYLMKnKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHL
|||.|||. .....|||  ....|||..    .|.. |..|...|
lvaaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll

0045450 (Phosphotyrosine protein) phosphatases II 107-247 3.2e-24 81.6 In-house 106-300 (307) alignment
Range on Protein: 107-247
Range on HMM: 106-300/307.0
DSTVILGALPFKSQT----QKLIDENVKGVITLNEEFETKH---------------------LCNSKQEWFAWGVTQLRLATV-----------------
. . |.   | ..      . | ...|. ...|.|..| ..                      . |....  . |..|..                    
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgw

-DFGNAPSFAQLLEGVKFIEDMRS---KGDSVYVHCKAGRGRSTTLVACYLMKNKN--------LNPEEAHLFIKSKRPQIRLASQQWIALQQFH
 |.|  |||..||. .. ......   ||  |.|||.|| ||. |..|.|||.           ....||  .....||..    .|.. |... 
pdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal

0043336 (Phosphotyrosine protein) phosphatases II 107-246 1.3e-21 72.7 In-house 87-272 (278) alignment
Range on Protein: 107-246
Range on HMM: 87-272/278.0
DSTVILGALPFKSQ----TQKLIDENVKGVITLNEEFETKH----------------------------------LCNS--KQEWFAWGVTQLRLATVDF
  ..|.   | ..      . . ...|. ...|.|..| ..                                  |. .  .  .  ...    |.  |.
prkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdh

GNAPSFAQLLEGVKFIEDMRS-KGDSVYVHCKAGRGRSTTLVACYLM-----KNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQF
|  .|...||. .|.. .... ..  |.|||.|| ||. |..|.||.     |......|||  .....||..    .|.. | ..
gvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 107-236 1.8e-12 41.0 In-house 12-133 (148) alignment
Range on Protein: 107-236
Range on HMM: 12-133/148.0
DSTVILGALPFKSQTQKLIDENVKGVITLNEefETKHLCNSKqewfawGVTQLRLATVDfGNAPSFAQLLEG-VKFIEDMRSKGDSVYVHCKAGRGRSTT
|. . ||. ..... ..| . .|  ... ..  | .   . .      |.  | .|  |  .     .. |  ..|.. ....|  | ||.. |. ||. 
dafLFlGskksaadlealkalgvtrivnatk..erdnaldqr......gieYlhvaldD.kpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssa

LVACYLMKNKNLNPEEAHLFIKSKRPQIRLA
|.  .|.. |.   .||  ..||||. ..  
lallwlidfkrvslkealalvkskrryvdpn

0040439 (Phosphotyrosine protein) phosphatases II 108-247 2.3e-22 75.3 In-house 54-242 (249) alignment
Range on Protein: 108-247
Range on HMM: 54-242/249.0
STVILGALPFKSQT----QKLIDENVKGVITLNEEFETKH-LC--------------------------------------NSKQEWFAWGVTQLRLAtv
 ..|.   | .. .    . | ..... ...|....| ..  |                                        ...   ...  . .   
rrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..

DFGNAPSFAQLLEGVKFIEDMRS---KGDSVYVHCKAGRGRSTTLVACYLM-----KNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFH
|.|  |||..||. .. ......   ||  |.|||.|| ||. |..|.|||     |......|||  ...|.||..    .|.. |... 
dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeal

0051429 (Phosphotyrosine protein) phosphatases II 110-250 2.9e-19 65.2 In-house 24-224 (272) alignment
Range on Protein: 110-250
Range on HMM: 24-224/272.0
VILGALP---FKSQTQKLIDENVKGVITLNEEFETKHlcnSKQEWFAWGVTQLRLATVDFGNAPSF----------------------------------
..... |      . ..| ....| ...| .|.| ..    | .... |.. |.| ..|..  . .                                  
lyrsggplpltaadfwrlkelgiktivdLrseeErgr...lkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagear

-----------------AQLLEGVKFIEDmrskGDSVYVHCKAGRGRSTTLVACYLMKnKNLN--------------PEEAHLFIKSKRPQIRLASQQWI
                  .||| .... |    |  |.|||.||..|. |.||..|.   ...              .|||   ....||...   .|..
evmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqyl

ALQQFHDHL
 |...  .|
flyeallel

0040438 (Phosphotyrosine protein) phosphatases II 111-254 5.6e-23 77.1 In-house 89-279 (317) alignment
Range on Protein: 111-254
Range on HMM: 89-279/317.0
ILGALPFKSQT----QKLIDENVKGVITLNEEFETKH--------------------LCNSKQEwfAWGVTQLRLAT-------------------VDFG
|.   | .. .    . . ...|. ...|.|..| .                      . | .|    |.| ..|                      |.|
IatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee..lagitlrtlevedlgdsesrtvthfhytgWpdhg

NAPSFAQLLEGVKFIEDMRSK-GDSVYVHCKAGRGRSTTLVACYLM-----KNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLHQKK
  ||. .||. ...... ... |  | |||.|| ||. |..|.|||     |......|||  .....||..    .|.. | ... .....|
vppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk

subfamily_DSP1_pd Subfamily DSP1 112-253 5.9e-17 56.2 In-house 27-159 (163) alignment
Range on Protein: 112-253
Range on HMM: 27-159/163.0
LGALPFKSQTQKLIDENVKGVITLNEEfetkhLCNSKQEWFAWGVTQLRlatvDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYL
||.    |... | ....  .. . .|     | |  .. | .   .|.    |  .|   . . | ..||.....|.  |..||.||  ||.||.  ||
lGsetvasnleiLkslgitailnvske.....ldnvfedlfeYkklkle....DspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclayl

MKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLHQK
||.|... |||. |.|..|. |.        | ... .| ..
mktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkllle

subfamily_DSP15_pd Subfamily DSP15 112-232 2.8e-15 50.7 In-house 11-121 (151) alignment
Range on Protein: 112-232
Range on HMM: 11-121/151.0
LGALPFKSQTQKLIDENVKGVITLNEefetkhlcnsKQEWFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYL
|| .   .....| ..|.  ......           .. .   .. . .|  |  .|     . | |.|| . |.|...|.||| ||  ||.|||. ||
lgnfrdskdeelLkeknithilsvhd..........nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MKNKNLNPEEAHLFIKSKRPQ
|   .|| ..|  .|| .|  
mtvtelnwrdalevikaaRsv

subfamily_DSP23_pd Subfamily DSP23 114-243 5.8e-17 56.7 In-house 16-138 (148) alignment
Range on Protein: 114-243
Range on HMM: 16-138/148.0
ALPF-KSQTQKLIDENVKGVITLNEEfetkhlCNSKQEWfAWGVTQLRLATVDFgNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLM
|||   .| . |.|  |. ...| ||      .. . |  . ..|  ||   |.   |.  |. | |. .|.  .|...| |||  ||||. |..||||.
alprlpdqyrylldlgvrylvsltee......grphvea.tpnltlvrlriddy.hppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylv

KNKNLNPEEAHLFIKSKRPQIRLASQQWIAL
|...|   ||   .. .||    . .|  ..
kerklaaaeaiaevrrlrpgsvetveqeklv

subfamily_Laforin_pd Subfamily Laforin 119-244 1.4e-13 44.1 In-house 44-165 (183) alignment
Range on Protein: 119-244
Range on HMM: 44-165/183.0
SQTQKLIDENVKGVITLNEEFeTKHLCNSKQEWfawGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLN
 ||.  | .|  |.   ||..  . | .  .|    |.. . | | |.       .| ..| ..  .  ||  |||||.|| ||||..|  .|.   . .
lqtesdivknssgiyrynenl.pitlkklykee...glayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgws

PEEAHLFIKSKRPQIRLASQQWIALQ
      |. .||| . .  .  |  .
lakvqyfllakrpvvyideealirae

DSPc Dual specificity phosphatase, catalytic domain 121-247 2e-21 71.2 Pfam-A 11-131 (133) alignment
Range on Protein: 121-247
Range on HMM: 11-131/133.0
TQKLIDENVKGVITLNEEFETKHL-CNSKQEWFAWGVTQlrlatvdFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNP
 ..| . ... || . .| . ... ..|..| .   | .       . ..   ..| | |.|||....|| .|.|||.||  || ||...|||| |||. 
lalleklgitlvinvtkevpnnnaikkseieylripved.......etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlsl

EEAHLFIKSKRPQIRLASQQWIALQQFH
.||  |.|..|..|.   ...  | .. 
neAyefvkerrskispnagflrqLleye

DSPc Dual specificity phosphatase, catalytic domain 121-247 2e-21 71.2 In-house 11-131 (133) alignment
Range on Protein: 121-247
Range on HMM: 11-131/133.0
TQKLIDENVKGVITLNEEFETKHL-CNSKQEWFAWGVTQlrlatvdFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNP
 ..| . ... || . .| . ... ..|..| .   | .       . ..   ..| | |.|||....|| .|.|||.||  || ||...|||| |||. 
lalleklgitlvinvtkevpnnnaikkseieylripved.......etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlsl

EEAHLFIKSKRPQIRLASQQWIALQQFH
.||  |.|..|..|.   ...  | .. 
neAyefvkerrskispnagflrqLleye

subfamily_STYXL1_pd Subfamily STYXL1 121-237 5e-12 39.3 In-house 28-140 (157) alignment
Range on Protein: 121-237
Range on HMM: 28-140/157.0
TQKLI--DENVKGVITLNEefETKHLCNSKQEwfawGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLN
... |  |  ||... .    ....| .. ..     .  |..|  |  .|  . .| | |.|||. . .|. | |  . |  ||......||| .|...
qnpaikkdlkvkahvnvsm..dadkliagvad....vakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkit

PEEAHLFIKSKRPQIRLAS
 ..|. ..|  .. ..   
lkkaykylkkCkenvkPnr

0036941 (Phosphotyrosine protein) phosphatases II 122-253 1.4e-19 66.0 In-house 78-279 (297) alignment
Range on Protein: 122-253
Range on HMM: 78-279/297.0
QKL------------------IDENVKGVITLNEEFETKH---------LCNSKQEWFAWGVTQLRLAT-------------------------------
.|                    ..||. ...|.|..|              .. ..   . || |.  .                               
rkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytg

-VDFGNAPSFAQLLEGVKFIEDMRS---KGDSVYVHCKAGRGRSTTLVACYLM--------KNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLH
  |.|  .|.|.||. .........   .|  |.|||.|| ||| |..|..||        |...... || ......||..    .|.. | ..  .| 
wpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

QK
.|
kk

subfamily_PTPDC1_pd Subfamily PTPDC1 122-255 1.1e-18 62.3 In-house 40-180 (182) alignment
Range on Protein: 122-255
Range on HMM: 40-180/182.0
QKLIDENVKGVITLNEEFETKHLCNSK---------QEWFAWGVTQLRLATVDFGnAPSFAQLLEGVKFIEDMRSKGdSVYVHCKAGRGRSTTLVACYLM
.|.... .| || |.|..|  .  ...         ... . |..   ..  |.| ..|  ..|. || ..   ..|  | ||| ||.||   |.||||.
dkfkesgikavinLqekgehasCGagleesGfsYdlealmeqgiyvynfgwkDyg.vasleriLdivkvvafalqeg.kvavhChaGlGrtGvliacylv

KNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLHQKKN
 .|.|..|.|  ...||||.   . .|   ...|. .|.....
yakrltaekaiklvrskrpksiqtreqvelvkefalfliplrk

0047943 (Phosphotyrosine protein) phosphatases II 123-245 3.8e-19 64.7 In-house 96-266 (273) alignment
Range on Protein: 123-245
Range on HMM: 96-266/273.0
KLIDENVKGVITLNEEFETKH-----------------------LCNSKQEWFAWGVTQLRLA-----------------TVDFGNAPSFAQLLEGVKFI
 . ..||. ...|.|..| .                         . | ..   . |..|.|                    |.|  ||...||| ....
mvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielv

EDMRS---KGDSVYVHCKAGRGRSTTLVACYLM-----KNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQ
.....   ..  |.|||.|| ||. |..|..|.     |.......||  ...|.|| .    .|.. | .
rkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflye

subfamily_CDC14_pd Subfamily CDC14 123-245 1.9e-14 48.3 In-house 207-320 (328) alignment
Range on Protein: 123-245
Range on HMM: 207-320/328.0
KLIDENVKGVITLNEEfetkhlCNSKQEWFAWGVTQLRLATVDfGNAPSFAQLLEGVKFIEDMrskGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEA
   ..||. |. ||..         .... . |.    |  .| |  || | . . .. .|..     .. |||||| ||  ||.||||||. ... .||
yfrknnvttvvrLnkk......lYdakkftdaGfdhkDlffiD.GstPsdaivkkfleiaeka...eGaiavhCkaGLGrtGtLiacylmkhyrftaaea

HLFIKSKRPQIRLASQQ-WIALQQ
  ...  ||   .. || ..  .|
iawlricrPGsvigpqqkfleekq

0050432 (Phosphotyrosine protein) phosphatases II 124-245 4.3e-19 64.4 In-house 128-293 (308) alignment
Range on Protein: 124-245
Range on HMM: 128-293/308.0
LIDENVKGVITLNEEFEtKHLCNSKQEWFAW---GVTQLRLATV--------------------------------------DFGNAPSFAQLLEGVKFI
. ..||. ...|....| .   .  | |      |...    ||                                      |.|  ||...||. ....
vweqnvrvIvmLtklve.ngrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelv

EDMRsKGDSVYVHCKAGRGRSTTLVACYLM-----KNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQ
.... .|  ..|||.|| ||. |..|..|.     |.......||  .....||.     .| . | .
rksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyr

0051299 (Phosphotyrosine protein) phosphatases II 124-242 2.3e-17 58.9 In-house 112-277 (288) alignment
Range on Protein: 124-242
Range on HMM: 112-277/288.0
LIDENVKGVITLNEEFETKH--------------------LCNSKQEWFAWGVTQLRLATV---------------------DFGNAPSFAQLLEGVKFI
. ..||. ...|....| .                      . | ...  . |..|..  .                     |.|  .|. .||. ....
vweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlv

EDMRSK-GDSVYVHCKAGRGRSTTLVACYLM-----KNKNLNPEEAHLFIKSKRPQIRLASQQWIA
 ..... |  |.|||.|| ||. |..|..|.     |.. ....||  .....||..    .| . 
rkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrf

0046845 (Phosphotyrosine protein) phosphatases II 124-246 1.1e-15 53.2 In-house 97-269 (284) alignment
Range on Protein: 124-246
Range on HMM: 97-269/284.0
LIDENVKGVITLNEEFETKHL---------------------CNSKQEWFAWGVTQLRLAT------------------VDFGNAPSFAQLLEGVKFIED
. ..||. ...|.|..| ..                      . |...   . |. |.|                     |.|  ||...||| ......
vweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvre

MRSK---GDSVYVHCKAGRGRSTTLVACYLMKNK--------NLNPEEAHLFIKSKRPQIRLASQQWIALQQF
....   |  . |||.|| ||. |..|..|...         .....||  .....||.     .| . . ..
llenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyea

subfamily_MKPLT_pd Subfamily MKPLT 135-247 1.1e-10 35.3 In-house 42-157 (164) alignment
Range on Protein: 135-247
Range on HMM: 42-157/164.0
LNEEFETKHLCNSKQE---WFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRP
. .. ...| .|  ||    |.  |  |.. . |  .    . |    ||. |    |  |.|||  |. ||..    .|.| |    .||. ..| .| 
vlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrs

QIRLASQQWIALQQFH
 ..      . | .| 
ivapnrGflkqlakfe

subfamily_MKPLV_pd Subfamily MKPLV 135-247 1.1e-10 35.3 In-house 42-157 (164) alignment
Range on Protein: 135-247
Range on HMM: 42-157/164.0
LNEEFETKHLCNSKQE---WFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRP
. .. ...| .|  ||    |.  |  |.. . |  .    . |    ||. |    |  |.|||  |. ||..    .|.| |    .||. ..| .| 
vlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrs

QIRLASQQWIALQQFH
 ..      . | .| 
ivapnrGflkqlakfe

0049772 (Phosphotyrosine protein) phosphatases II 143-253 6.1e-27 90.6 In-house 168-276 (314) alignment
Range on Protein: 143-253
Range on HMM: 168-276/314.0
HLCNSKQEWFAWGVTQLRLATVDfGNAPSFAQLLEGVKFIEDMrSKGDSVYVHCKAGRGRSTT-LVACYLMKNKNLNPEEAHLFIKSKRPqIRLASQQWI
  ..... .  .|.. ||. . | |.||......| ..|||.  .||  |.||||||.||..| .||.||||  ....|||  ....||| |.    .. 
eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfie

ALQQFHDHLHQK
 |.|.  .|...
qleqyefileal

subfamily_VSP_pd Subfamily VSP 143-230 1.7e-07 25.3 In-house 80-170 (212) alignment
Range on Protein: 143-230
Range on HMM: 80-170/212.0
HLCNSKQEWFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGD--SVYVHCKAGRGRSTTLVACYLMKNKNLNP-EEAHLFIKSKR
 ||  ..   ..   ...  ..|  | |.. .||   | .... .|     . .||| |.||. |.| ..|.. . ..  .|.  .. ..|
nlcseraydekyfnnrvkriliddhnvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerr

subfamily_CDKN3_pd Subfamily CDKN3 143-230 5.9e-06 20.0 In-house 87-174 (202) alignment
Range on Protein: 143-230
Range on HMM: 87-174/202.0
HLCNSKQEWFAWGVTQLRLaTVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYL-MKNKNLNPEEAHLFIKSKR
 . .  ...   |..      .  | .|. |. |. .. .     ..    |||  | |||. ..|| | . .  ..|..|   ..  .
rvrrlldlyqqaglivhhy.piadglvpdiasclkileelrinlkayrktlvhcygglgrsslviaclllylddtiepkdaidklrdlk

subfamily_RNGTT_pd Subfamily RNGTT 147-233 2.1e-07 24.8 In-house 69-158 (189) alignment
Range on Protein: 147-233
Range on HMM: 69-158/189.0
SKQEWFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDM--RSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEA-HLFIKSKRPQI
 |.|    |... .|..   |.||.  |  |  | .|.   ..  . . |||. |  |.  |...||..... . |.| .|| |.. | |
dkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGi

subfamily_DSP19_pd Subfamily DSP19 149-237 1.7e-17 58.2 In-house 49-137 (152) alignment
Range on Protein: 149-237
Range on HMM: 49-137/152.0
QEWFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLAS
.. |.  .| | .  .|  ..   ..| | ..|||. |||   |.|||.||. ||...|  ||||...|. |||   ....|| |.  .
pnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpcikPne

subfamily_Slingshot_pd Subfamily Slingshot 151-254 6.5e-14 45.7 In-house 58-161 (169) alignment
Range on Protein: 151-254
Range on HMM: 58-161/169.0
WFAWGVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHL
.|.  .. |..   |  ..  ...  |  ||||  ..|| .| |||| |  ||.. |  | ||. .|. |||. ..|..|  |.  .  .  |....  |
ffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGil

HQKK
. .|
eask

PTPlike_phytase Inositol hexakisphosphate 152-212 5.1e-08 27.7 Pfam-A 89-147 (149) alignment
Range on Protein: 152-212
Range on HMM: 89-147/149.0
FAWGVTQLRLATVDfGNAPSFAQLLEGVKFIEDMrSKGDSVYVHCKAGRGRSTTLVACYLM
  .||.  |..  |  .||..... . |..|... .. ... ..|.|||||.|| .... .
egfgvkYvRipitd.eqapeeedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadL

PTPlike_phytase Inositol hexakisphosphate 152-212 5.1e-08 27.7 In-house 89-147 (149) alignment
Range on Protein: 152-212
Range on HMM: 89-147/149.0
FAWGVTQLRLATVDfGNAPSFAQLLEGVKFIEDMrSKGDSVYVHCKAGRGRSTTLVACYLM
  .||.  |..  |  .||..... . |..|... .. ... ..|.|||||.|| .... .
egfgvkYvRipitd.eqapeeedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadL

subfamily_DSP14_pd Subfamily DSP14 155-254 3e-17 57.0 In-house 49-148 (157) alignment
Range on Protein: 155-254
Range on HMM: 49-148/157.0
GVTQLRLATVDFGNAPSFAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLHQKK
.. .....  |  .|   . . | .. ||... ||  . |||.||. || .|.  |||| ..|. .||.  .||.||.||  .  |  |...  .|..|.
diervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgks





Y_phosphatase Protein-tyrosine phosphatase 155-230 9.7e-07 23.8 Pfam-A 134-216 (235) alignment
Range on Protein: 155-230
Range on HMM: 134-216/235.0
GVTQLRLATVDFGNAP-SFAQLLegvKFIEDMRSKG----DSVYVHCKAGRGRSTTLVACYLMKNKNLN-----PEEAHLFIKSKR
 |.|| . .    ..| |  .||   ..|......      .| |||.|| ||. |.||  .. ..  .       ..   ....|
evkqlhytnWpdhgvpespksll...dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqR

Y_phosphatase Protein-tyrosine phosphatase 155-230 9.7e-07 23.8 In-house 134-216 (235) alignment
Range on Protein: 155-230
Range on HMM: 134-216/235.0
GVTQLRLATVDFGNAP-SFAQLLegvKFIEDMRSKG----DSVYVHCKAGRGRSTTLVACYLMKNKNLN-----PEEAHLFIKSKR
 |.|| . .    ..| |  .||   ..|......      .| |||.|| ||. |.||  .. ..  .       ..   ....|
evkqlhytnWpdhgvpespksll...dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqR

subfamily_PTEN_pd Subfamily PTEN 163-232 1.1e-09 33.5 In-house 86-158 (184) alignment
Range on Protein: 163-232
Range on HMM: 86-158/184.0
TVDFGNAPSFAQLLEGVKFIEDMRSK--GDSVYVHCKAGRGRSTTLVACYLMKNKNLNPE-EAHLFIKSKRPQ
 .|  |.|..  | | |. ||.  ..     | ||||||.||. .|...||.|.. |. . ||  . ...| .
pfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtk

PTPc_DSPc_SM00012 172-220 2e-08 29.7 In-house 22-70 (105) alignment
Range on Protein: 172-220
Range on HMM: 22-70/105.0
FAQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPE
. .||. ||  .  .... .| |||.|| ||. |.|| ... ... . .
ilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket

subfamily_DSP6_pd Subfamily DSP6 173-250 6.5e-15 49.0 In-house 77-154 (158) alignment
Range on Protein: 173-250
Range on HMM: 77-154/158.0
AQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHL
. . | ..||.. |||  .| ||| ||  || |.. .||||...|  ..|. ..|.....|    .    | .|  .|
kffPeaiefidearskkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 173-221 3e-06 21.5 In-house 193-241 (307) alignment
Range on Protein: 173-221
Range on HMM: 193-241/307.0
AQLLEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEE
   |  . ..| .| . . | ||| || ||| |.||  |...| .. ..
qinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGin

subfamily_DSP10_pd Subfamily DSP10 176-236 7.9e-18 58.8 In-house 79-139 (159) alignment
Range on Protein: 176-236
Range on HMM: 79-139/159.0
LEGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLA
 | ..|||..|.|| .| |||.||  ||.|.|  ||||..||. ..|. |.|.||| |   
eealefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpiisPn

subfamily_DSP8_pd Subfamily DSP8 177-251 1e-15 51.7 In-house 81-155 (159) alignment
Range on Protein: 177-251
Range on HMM: 81-155/159.0
EGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLH
. |.||. ..|.  .| ||. ||. ||.|.. .|.||. ... .||. |.|.||| |    .    | ... .|.
ksvefidkaksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelk

subfamily_DSP3_pd Subfamily DSP3 177-231 6.5e-11 36.1 In-house 84-139 (162) alignment
Range on Protein: 177-231
Range on HMM: 84-139/162.0
EGVKFIED-MRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRP
. .|||.. . .|   |.|||..|  ||.|||  |||  ....  ||   ...|| 
taakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkRe

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 177-253 2e-09 30.7 In-house 68-144 (145) alignment
Range on Protein: 177-253
Range on HMM: 68-144/145.0
EGVKFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDHLHQK
|   ||.  . .|  |.||| ||  || |.   .|||  |.   ||   ..|.| .     .   .| ...  |...
evtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekqlkee

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 178-235 1.1e-08 28.6 In-house 78-137 (154) alignment
Range on Protein: 178-235
Range on HMM: 78-137/154.0
GVKFIEDMR--SKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRL
  .||.|     . . | ||...|  ||..|.  |||......  .|  ..|. |..|. 
afefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryiikP

0048567 (Phosphotyrosine protein) phosphatases II 179-249 4.7e-17 56.7 In-house 64-137 (157) alignment
Range on Protein: 179-249
Range on HMM: 64-137/157.0
VKFIEDMRSKGDSVYVHCKAGR---GRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQFHDH
 ||..... .|  ..||||||.   ||. ||..|||..  ...||||  ...  || . .  ... .|  .. .
nkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslynlt

subfamily_LRR-DSP_pd Subfamily LRR-DSP 180-246 2.3e-12 40.6 In-house 189-254 (263) alignment
Range on Protein: 180-246
Range on HMM: 189-254/263.0
KFIEDMRSKGdSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIRLASQQWIALQQF
 |||. | ||  | |||.||  ||.||| .||||...|. .||  ....|||.|.        |...
afieeGrkkG.GvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkky

subfamily_MSG5_pd Subfamily MSG5 180-234 3e-08 26.9 In-house 90-144 (165) alignment
Range on Protein: 180-234
Range on HMM: 90-144/165.0
KFIEDMRSKGDSVYVHCKAGRGRSTTLVACYLMKNKNLNPEEAHLFIKSKRPQIR
. |   .||.. . |||. |  ||..|.  |.||  ||  ..|.  .||.  .| 
riihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddis

subfamily_PRL_pd Subfamily PRL 186-247 1.6e-07 25.5 In-house 87-146 (151) alignment
Range on Protein: 186-247
Range on HMM: 87-146/151.0
RSKGDSVYVHCKAGRGRSTTLVACYLMKnKNLNPEEAHLFIKSKRPQiRLASQQWIALQQFH
.. . .| ||| || ||.  |||  |.  . ...|.|  ||..||    . |.|   |....
eepkstvavhcvaGlGraPvlvalalie.aGmkyedavefirekrrg.ainskqlkflekyk