Gene SSH in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily Slingshot
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP021_AA protein Get Run
NvecP021_AA_273-418 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
DEK_C DEK C terminal domain 220-270 1.3e-17 52.9 Pfam-A 3-53 (54) alignment 
Range on Protein: 220-270
Range on HMM: 3-53/54.0
KLLRHKLREVMMTVDLEEVTSRQVRELVEAEVQMDLKQYKQYIDKEMLTIF
. .. ..||.....|||.||..|||. .||....||...|..|....  ..
eeikeevreiLkeaDLetvTkkqvrkeLearlgvdLserKafIkdlieefL
subfamily_LRR-DSP_pd Subfamily LRR-DSP 235-414 1e-30 100.7 In-house 88-258 (263) alignment 
Range on Protein: 235-414
Range on HMM: 88-258/263.0
LEEVTSRQVRELVEAEVqmDlkqYKQYidKEMltIFGQMDSASKIYDHVYLGSEWNASNLEELKENGVEYVLNITKEIDNFFAGTFTYFNI-RLWDLEDS
|.|.  |. |||.   |  .   |||   ...  |. .    ..| |...||.   | |   ||..|| ..|    ... .|  .| |. |  . | .. 
lkelnirdnrelislpv..e...ykqv..esl..itlvssvPdeiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdea

NLLPYWDETFKFINQARDKGSkVLVHCKRGISRSASTVIAYGMKEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYEGIL
..  ...||  ||.. |.||  |||||. |.|||.. ||.| ||     .....  |...|  ..||.|| .||  ||  |
disqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl
0045450 (Phosphotyrosine protein) phosphatases II 251-411 4.2e-26 87.8 In-house 18-300 (307) alignment 
Range on Protein: 251-411
Range on HMM: 18-300/307.0
VQMDLKQYKQYIDKEMLTIFGQMD----------------------------------------------SASKIYDHVYLGSEWNASNL----------
|...|.  .. . ||. ... . .                                               || ......|  .   ...          
vllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlp

-------EELKENGVEYVLNITKEIDN----------------------------FFAGTFTYFNIRLWDL-----------------EDSNLLPYWDET
       . |.|.||......|.....                               . .|.......||                  | .. |...|.
etvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeel

FKFINQARD------KGSKVLVHCKRGISRSASTVIAYGMKEYG--------TSLNDTMKHVKSRRQCVNPNQGFWKQLITYE
..||...|.      ||..|||||. |..|... ..|| |....         .| ...|.....| .. .|......|. ..
ldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal
subfamily_Slingshot_pd Subfamily Slingshot 258-425 8.5e-91 295.9 In-house 1-168 (169) alignment 
Range on Protein: 258-425
Range on HMM: 1-168/169.0
YKQYIDKEMLTIFGQMDSASKIYDHVYLGSEWNASNLEELKENGVEYVLNITKEIDNFFAGTFTYFNIRLWDLEDSNLLPYWDETFKFINQARDKGSKVL
||..||.|||.|.||.||||||.||||||||||||||||||||||||.||.||||||||...|.|.|||..| |...||.||.||.|||..|..||||||
ykefidnemlvilgqldsaskifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvl

VHCKRGISRSASTVIAYGMKEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYEGILNSSRHRYNELF
||||.|.|||||||||| |||||.||......||.||....||.||.||| .|||||..|..|.|.||
vhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGileaskqrhnklf
0044763 (Phosphotyrosine protein) phosphatases II 266-416 2.6e-40 133.3 In-house 13-172 (178) alignment 
Range on Protein: 266-416
Range on HMM: 13-172/178.0
MLTIFGQMDSASKIYDHVYLGSEWNASNLEELKENGVEYVLNITKEIDNFFAGT---------FTYFNIRLWDLEDSNLLPYWDETFKFINQAR-DKGSK
. .  ...  ||.|....|||| ..|..|| |||.|. ...|.|.|. ..| ..         ..|..| . |  . .|| ...|...||..|. .||..
eglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggp

VLVHCKRGISRSASTVIAYGMKEYGTSLNDTMKHVKSRRQcVNPNQGFWKQLITYEGILNS
|||||. |..||.. |.|| ||..| ||.. ...|..||  ..||.|...||. .| .|..
vlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk
subfamily_DSP14_pd Subfamily DSP14 273-416 5.2e-39 127.7 In-house 4-146 (157) alignment 
Range on Protein: 273-416
Range on HMM: 4-146/157.0
MDSASKIYDHVYLGsEWNASNLEELKENGVEYVLNITKEIDNFFAGTFTYFNIRLWDLEDSNLLPYWDETFKFINQARDKGSKVLVHCKRGISRSASTVI
. . |.| .. .|.    |.. |.||....  ..|.| |. |  .  . . .... | ....| ...||. . |.... || |.||||. |.||||| ..
laalsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslcl

AYGMKEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYEGILNS
|| ||   .||... |.|||.|  ..||.|||||||.||  |. 
aylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkg
0049772 (Phosphotyrosine protein) phosphatases II 273-425 4.1e-33 110.8 In-house 155-284 (314) alignment 
Range on Protein: 273-425
Range on HMM: 155-284/314.0
MdsaskiydhvylgSEWNASNLEELKengveyvlnitKEI--DNFFAGT-FTYFNIRLWDlEDSNLLPYWDETFKFINQArDKGSKVLVHCKRGISRSAS
.             .|..|..||.||           .|.  ...| .. ..|..| ..| .. .|| ..|| ..||..| |||..|||||| |..|...
g.............neptaadlellk...........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgt

-TVIAYGMKEYGTSLNDTMKHVKSRRQcVNPNQGFWKQLITYEGILNSSRHRYNELF
  |.|| || .| ||......|...|  .|||.||..||. || ||. ...... | 
fvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefilealleylkflk
subfamily_DSP1_pd Subfamily DSP1 274-413 2.4e-42 138.8 In-house 16-155 (163) alignment 
Range on Protein: 274-413
Range on HMM: 16-155/163.0
DSASKIYDHVYLGSEWNASNLEELKENGVEYVLNITKEIDNFFAGTFTYFNIRLWDLEDSNLLPYWDETFKFINQARDKGSKVLVHCKRGISRSASTVIA
|   || |..||||| .||||| ||..|.  .||..||.||.|  .|.| .. | | .. ..  ...|  .||.....|. |||.||. |||||.. ..|
dPvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlcla

YGMKEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYEGI
| ||.  .||.. .. ||.||....|| || .||..||  
ylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekk
0046846 (Phosphotyrosine protein) phosphatases II 274-414 1.3e-27 92.1 In-house 10-172 (176) alignment 
Range on Protein: 274-414
Range on HMM: 10-172/176.0
DSASKIYDHVYLGSEW----------NASNLEELKENGVEYVLNITKEI-----------DNFFAGTFTYFNIRLWDLEDSNLlPYWDETFKFINQARDK
 . . |.....||| .           |..||.|||.|...|.|.|.|.           . . .  ..|...   |    .|  ...| ..||..|...
ldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealke

GSKVLVHCKRGISRSASTVIAYGMKE-YGTSLNDTMKHVKSRRQ-CVNPNQGFWKQLITYEGIL
| .|||||. ||.|..  |.|| ..  .| |.......|...|  .. ........|  .|  |
ggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
subfamily_DSP10_pd Subfamily DSP10 275-418 1.3e-40 132.8 In-house 13-157 (159) alignment 
Range on Protein: 275-418
Range on HMM: 13-157/159.0
SASKIYDHVYLGSEWNASNLEELKENGVEYVLNITKEIDNFFAG-TFTYFNIRLWDLEDSNLLPYWDETFKFINQARDKGSKVLVHCKRGISRSASTVIA
 ||... ...|||| .|..|. |.. ....|||.|... |.|.. ...|  | . | .  ||  |..| ..||..|| |||.|||||. ||||||. |||
pasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvia

YGMKEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYEGILNSSR
| ||. . ||||  |.||..|  . || .|  ||. .|  || |.
YlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnksk
0043147 (Phosphotyrosine protein) phosphatases II 275-415 6.2e-30 99.6 In-house 18-161 (172) alignment 
Range on Protein: 275-415
Range on HMM: 18-161/172.0
SASKIYDHVYLGSEWNASNLEELKENGVEYVLNITKE---IDNFFAGTFTYFNIRLWDLEDSnLLPYWDETFKFINQ--ARDKGSKVLVHCKRGISRSAS
   .. .. .....  |.... |||.|. ...|.|..    ....   ..|  .   |     || ...|...||..  |...| .|||||. |..|.. 
ipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgt

TVIAYGMKeYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYEGILN
 |.|| |. .| || .....|...| .. .|......|  .| .| 
lvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklll
subfamily_DSP3_pd Subfamily DSP3 275-415 6.7e-29 94.6 In-house 10-158 (162) alignment 
Range on Protein: 275-415
Range on HMM: 10-158/162.0
SASKIYDHVYLGSEWNASNLEELKENGVEYVLNITKE----I---DNFFA-GTFTYFNIRLWDLEDSNLLPYWDETFKFINQARD-KGSKVLVHCKRGIS
..  .|...|.| |  |.. ..||. |. .||| ..     .   ..|.    ..|. . . |   ..|  |.....|||..| . | .||||||. |.|
evdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvs

RSASTVIAYGMKEYGTSLNDTMKHVKSRRQcVNPNQGFWKQLITYEGILN
|||  |.|| |     .|.. ...|...|. . ||.|| |||....  |.
RsatlvlayLmirrkmtlveairtvrkkRe.ilPneGFlkqLaeldeelk
0045098 (Phosphotyrosine protein) phosphatases II 275-412 1.8e-26 88.6 In-house 21-269 (278) alignment 
Range on Protein: 275-412
Range on HMM: 21-269/278.0
SASKIYDHVYLGSEW-----------------------------------------NASNLEELKENGVEYVLNITKEIDN-------------------
. |.|....|||. .                                          |.... |.|.|.......|.....                   
ipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygd

---------------------------------FFAGTFTYFNIRLWDLEDSNLLPYWDETFKFINQARD--------------KGSKVLVHCKRGISRS
                                 ..   . |...   .  ....| ...| ..||..|..              .| .|||||. |..|.
ftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRt

ASTVIAYGMKEY---GTSLNDTMKHVKSRRQC-VNPNQGFWKQLITYEG
.  |.|| |.|.   | .| .. |...|.| . . .|......|. .. 
GtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefll
0051082 (Phosphotyrosine protein) phosphatases II 275-410 1.8e-24 81.5 In-house 7-149 (151) alignment 
Range on Protein: 275-410
Range on HMM: 7-149/151.0
SASKIYDHVYLGSEWNASNLEELKENGVEYVLNITKEI------DNFFAGTFTYFNIRLWDLEDSNLLPYWDETFKFINQARDK-GSKVLVHCKRGISRS
 .| . ...|...   | .||.|||.|. ...|...|       . . .  .....| ..|  | .|  ..|.  .|.....|| . .|||||. |..|.
nfsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRT

ASTVIAYGMKeYGTSLNDTMKHVKSRRQ-CVNPNQGFWKQLITY
.  |..| |. .| ||..........|  .|.|||.|..||. .
Gtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_DSP19_pd Subfamily DSP19 276-413 7.9e-44 143.7 In-house 12-149 (152) alignment 
Range on Protein: 276-413
Range on HMM: 12-149/152.0
ASKIYDHVYLGSEWNASNLEELKENGVEYVLNITKEIDNFFAGTFTYFNIRLWDLEDSNLLPYWDETFKFINQARDKGSKVLVHCKRGISRSASTVIAYG
.... ...||||   |.. |.|||... ..||.. ...|.|.  ||| .| ..||.. .|| |..|...||..||.|   |||||. |.||||| |||| 
vgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviayl

MKEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYEGI
||.  .||..... |.. |.|..||.||.||| .||  
mkkeelsleealelvrearpcikPneGFikqLkeyeae
PTPc_motif_SM00404 276-411 2.6e-39 129.3 In-house 2-138 (140) alignment 
Range on Protein: 276-411
Range on HMM: 2-138/140.0
ASKIYDHVYLGSEWNASNLEELKENGVEYVLNITKEIDNF-FAGTFTYFNIRLWDLEDSNLLPYWDETFKFINQARDKGSKVLVHCKRGISRSASTVIAY
 |.| .|.||||. .|.|.. ||..|...|.|.|.|...      |....| | | | ..|..|.|.. .||..|..|| ||||||. |.||||. .|||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

GMKEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYE
 |.... ||.. .. ||.||....|| .|..||| ||
lmryrqlslaeayefvkerRpiispnlnfvrqLieye
subfamily_DSP6_pd Subfamily DSP6 276-417 3.9e-39 127.7 In-house 14-157 (158) alignment 
Range on Protein: 276-417
Range on HMM: 14-157/158.0
ASKIYDHVYLGSEWNASNLEELKENGVEYVLNITKEIDNFFA--GTFTYFNIRLWDLEDSNLLPYWDETFKFINQARDKGSKVLVHCKRGISRSASTVIA
  .| ...||||. .||||| ||. ...||||.|....|.|.  | ..| .| . |    ||  .. |...||..|| | |||||||  |||||   ..|
pveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtla

YGMKEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYEGILNSS
| ||..  ||||. . ||.|.  . ||  | .||. .|  |..|
ylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrls
0048076 (Phosphotyrosine protein) phosphatases II 276-414 2.6e-36 119.8 In-house 4-142 (145) alignment 
Range on Protein: 276-414
Range on HMM: 4-142/145.0
ASKIYDHVYLGSEWNASNLEELKENGVEYVLNITKEIDNFFAGTFTYFNIRLWDLEDSNLLPYWDETFKFINQARDKGSKVLVHCKRGISRSASTVIAYG
.|.|....|||| ..|..||.||..|. .|||.| |......  ..|... ..| .  .|| ...| ..||..|...| .|||||. |..|... |.|| 
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MKEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYEGIL
|...| || .....|.|.| ...||.|....|. .| .|
mlllgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_DSP8_pd Subfamily DSP8 276-415 1.8e-32 106.1 In-house 15-155 (159) alignment 
Range on Protein: 276-415
Range on HMM: 15-155/159.0
ASKIYDHVYLGSEWNASNLEELKENGVEYVLNITK-EIDNFFAGTFTYFNIRLWDLEDSNLLPYWDETFKFINQARDKGSKVLVHCKRGISRSASTVIAY
  .| ...||||. .. . | |...|..||||. .  ..  .     .. . . |  | .|||..|....||..|. . ..||||.  ||||||. .|||
ptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiay

GMKEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYEGILN
 ||.   ||... ..||..|. ..||  | .||. ||  |.
imktlemsldeayrfvkekrptispnlnflgqLleyekelk
0041856 (Phosphotyrosine protein) phosphatases II 276-415 6.8e-32 105.9 In-house 19-173 (182) alignment 
Range on Protein: 276-415
Range on HMM: 19-173/182.0
ASKIYDHVYLGSEWN--------------ASNLEELKENGVEYVLNITKEI---DNFFAGTFTYFNIRLWDLEDSNllpyWDETFKFINQARDKGSKVLV
 ..| ...|||| ..              |..|. |||.|. ...|.| |    ...    ..|...   | .  .    .||...||......| .|||
ldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvlV

HCKRGISRSASTVIAYGMKEYGTSLNDTMKHVKSRRQ--CVNPNQGFWKQLITYEGILN
||. |..|... |.|| ||..| || ...|.|.|||   ...|||.|. ||. .| .|.
HCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll
0037934 (Phosphotyrosine protein) phosphatases II 276-411 2.9e-24 81.4 In-house 39-238 (243) alignment 
Range on Protein: 276-411
Range on HMM: 39-238/243.0
ASKIYDHVYLGSE--------WNASNLEELKENGVEYVLNITKEI---------------------------------------------DNFFAGTFTY
 ...........         . ||... |.|.|.......|...                                             |...   . |
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

FNIRLWD----LEDSNLLPYWDETFKFINQ-----ARDKGSKVLVHCKRGISRSASTVIAYGMKEY-GTSLNDTMKHVKSRRQC-VNPNQGFWKQLITYE
  .   |     . ..|| ..||. .||..     |.|.|..|||||. |..|..  ..|| |... | .| ...|.....| . . ........|. ..
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 276-411 4.5e-23 75.3 In-house 3-149 (154) alignment 
Range on Protein: 276-411
Range on HMM: 3-149/154.0
ASKIYDHVYLGSEWNASNLEELKENGVEYVLNITKEIDNFFAGT---------FTYFNIRLWDLEDSNLLPYWDETFKFINQAR--DKGSKVLVHCKRGI
 ||   ..|..|   | |  .|... .. .||.   |.| |.           . | |..|.|  . ...   | .|.||..|    . .|||||...|.
nskeaiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGv

SRSASTVIAYGMKEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYE
||||. .|.| |..   ||  ... .|. |  ..||||| |||  .|
srsaallisylmdklkislslalellkdsryiikPnqGflkqleife
0048179 (Phosphotyrosine protein) phosphatases II 277-414 1.1e-35 117.7 In-house 5-144 (144) alignment 
Range on Protein: 277-414
Range on HMM: 5-144/144.0
SKIYDHVYLGSEWNASNLEELKENGVEYVLNITKEIDNFFAGTF--TYFNIRLWDLEDSNLLPYWDETFKFINQARDKGSKVLVHCKRGISRSASTVIAY
|.|....|||| . |..||.||..|. .|.|.| | .. | . .  .|... . | .  .|| ...|...||..|...| .|||||. |..|... |.||
seilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay

GMKEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYEGIL
 ||..| ||......|.||| ...||.|....|. || .|
lmkklglsleealalvrsrrpgavpnpgqlrfLleyekll
subfamily_DSP12_pd Subfamily DSP12 277-414 9e-34 111.1 In-house 3-143 (155) alignment 
Range on Protein: 277-414
Range on HMM: 3-143/155.0
SKIYDHVYLGSEWNASNLEELKENGVEYVLNITKE-IDNF--FAGTFTYFNIRLWDLEDSNLLPYWDETFKFINQARDKGSKVLVHCKRGISRSASTVIA
|.| . .|||.  .. . | ||| ... || ..|| ....   .|. .. .| . | .. ..| . ||...||..|.... .|||||. |.|||...|||
srilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviA

YGMKEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYEGIL
| ||... ||.. .| ||. .. ..||.|| .||  .| . 
YlmkkeklslekAlklvkekkpeiepNegFleQLklfekmg
subfamily_DSP15_pd Subfamily DSP15 277-412 5.4e-29 95.2 In-house 3-137 (151) alignment 
Range on Protein: 277-412
Range on HMM: 3-137/151.0
SKIYDHVYLGSEWNASNLEELKENGVEYVLNITKEIDNFFAGtFTYFNIRLWDLEDSNLLPYWDETFKFINQARDKGSKVLVHCKRGISRSASTVIAYGM
||.   .|||   .... | |||. .  .|..  .  ...   ..|  |.. |  . .|  . .|. .|| ..| |. .|||||  |.|||.  |.|| |
skvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlm

KEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYEG
     . .|... .| .|.. ||| || .||  || 
tvtelnwrdalevikaaRsvanPnfGfkrqlkeyek
0036282 (Phosphotyrosine protein) phosphatases II 277-415 1.7e-23 78.6 In-house 13-170 (174) alignment 
Range on Protein: 277-415
Range on HMM: 13-170/174.0
SKIYDHVYLGSEWNAsNLEELKENGVEYVLNITKEI---------------DNFFAGTFTYFNIRLWDLEDSNLLPyWDETFKFINQARDK--GSKVLVH
| | .....|.   | ..|.|||.|...|.. ..|.               . .    ..|. .   | .  .|   ..| .||...|. .  | .||||
syitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

CKRGISRSASTVIAYGMKEYGT-SLNDTMKHVKSRR---QCVNPNQGFWKQLITYEGILN
|. |..|..  |.|| |. ..  || | ...|...|    .. ........|  .| .|.
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfeklls
0042113 (Phosphotyrosine protein) phosphatases II 277-411 4.3e-22 74.1 In-house 48-239 (245) alignment 
Range on Protein: 277-411
Range on HMM: 48-239/245.0
SKIYDHVYLGSEWNASNLE----ELKENGVEYVLNITKEIDN-------------------------------------------FFAGTFTYFNIRLWD
..|........   ....|     |.|.|.......|.| ..                                               ... ....  .
yritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylp

LEDSNLLPYWDETFKFINQARD-----KGSKVLVHCKRGISRSASTVIAYGM-----KEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYE
 .| .  .. .  ..|.. .|.     .. .|||||. |..|..  ..|| |     ||.| || ...|...|.| .. ........|. ..
wpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
0036941 (Phosphotyrosine protein) phosphatases II 277-411 1.8e-20 68.9 In-house 20-273 (297) alignment 
Range on Protein: 277-411
Range on HMM: 20-273/297.0
SKIYDHVYLGSEWNASNLEELK----------------------------------------------------------ENGVEYVLNITKEIDNFF--
...... .||| . |...| |.                                                          |..|. ....|..... .  
eellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrek

-----------------------------AGTFTYFNIRLWD----------------LEDSNLLPYWDETFKFINQARD------KGSKVLVHCKRGIS
                              ...|.......|                  | .. ..... ..||...|.      .|..|||||. |..
caqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvg

RSASTVIAYGM--------KEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYE
||.. ..|. |        ||.| .. ...|.....| .. .. .....|. ..
RsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeal
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 278-411 1.2e-29 96.7 In-house 9-144 (148) alignment 
Range on Protein: 278-411
Range on HMM: 9-144/148.0
KIYD-HVYLGSEWNASNLEELKENGVEYVLNITKEIDNFFAGTFT-YFNIRLWDLEDSNLLPYWDETFKFINQARDKGSKVLVHCKRGISRSASTVIAYG
.|.| ...|||   |..|| ||. ||  . | ||| || ..     |....| | .. .|  ....  .|...|.|.| .||||.. |.|||.  .... 
eikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwl

MKEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYE
..    ||.. .  |||.|. |.||.|| |||  .|
idfkrvslkealalvkskrryvdpnlgfLkqLaele
0049260 (Phosphotyrosine protein) phosphatases II 278-415 1.3e-27 91.7 In-house 10-150 (152) alignment 
Range on Protein: 278-415
Range on HMM: 10-150/152.0
KIYDHVYLGSEWNASNLEELKENGVEYVLNITKEIDNF---FAGTFTYFNIRLWDLEDSNLLPYWDETFKFINQ-ARDKGSKVLVHCKRGISRSASTVIA
..  . ..|... |.... |||.|. .....|.. ..    ..  ..|...   |    .|  . .. ..||.. |.||| .|||||. |..|..  |.|
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaa

YGMKeYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYEGILN
| |. .| || .....|...| ...||.|....|  .|..|.
ylml.lgvsleeavalvrekRpgavpnpgqlrflyefekllk
0040439 (Phosphotyrosine protein) phosphatases II 278-411 2.3e-26 88.3 In-house 31-242 (249) alignment 
Range on Protein: 278-411
Range on HMM: 31-242/249.0
KIYDHVYLGSEWNASNLE------------------------ELKENGVEYVLNITKEIDN---------------------------------------
.|.. ..|..  ||| ..                         |.|.|.......|..  .                                       
silpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtle

----FFAGTFTYFNIRLWDLEDSNLLPYWDETFKFINQARD------KGSKVLVHCKRGISRSASTVIAYGM-----KEYGTSLNDTMKHVKSRRQCVNP
     .  ..|.  |.  |. | .. |. .....||...|.      ||..|||||. |..|..  ..|| |     ||.| .| ...|...|.| .. .
ltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavq

NQGFWKQLITYE
|......|. ..
npeqyrflyeal
subfamily_STYX_pd Subfamily STYX 278-414 1e-25 83.8 In-house 14-157 (166) alignment 
Range on Protein: 278-414
Range on HMM: 14-157/166.0
KIYDHVYLGSE--WNASNLEELKENGVEYVLNITKEIDN-----FFAGTFTYFNIRLWDLEDSNLLPYWDETFKFINQARDKGSKVLVHCKRGISRSAST
.|   ..||       | || ||..|. ... | ..|.       |  .| |. . . |    |.. |  .. .||... .|| ||||| . ||||||. 
eilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal

VIAYGMKEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYEGIL
|||| |. ||    .....|. || |.|||.|| .||  || | 
viayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiy
PTEN_1 279-417 3.4e-24 80.7 In-house 44-194 (196) alignment 
Range on Protein: 279-417
Range on HMM: 44-194/196.0
IYDHVYLGSEWNA-SNLEELKENGVEYVLNITKEIDN---------FFAGTFTYFNIRLWDLEDSNLLPYWDETFKFINQAR--DKGSKVLVHCKRGISR
| ...|.||.  . ..|..|||.|.  |.| . | ..         ||.. ..| ..   |   ..|   .|.  .||....  ..| .|||||| |..|
ideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgR

SASTVIAYGMKEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYEGILNSS
|.  |.|| |. .. . ......|...| ...||......|. |.  |...
sGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae
subfamily_MKPLT_pd Subfamily MKPLT 280-413 3.3e-29 95.5 In-house 26-159 (164) alignment 
Range on Protein: 280-413
Range on HMM: 26-159/164.0
YDHVYLGSEWNASNLEELKENGVEYVLNITKEIDNFFAGTFTYFNIRLWDLEDSNLLPYWDETFKFINQARDKGSKVLVHCKRGISRSASTVIAYGMKEY
 |..|||   .| | . ||.  .....|...|  . |. .. | .... |  |..| .. . . ||. .| | | .||||| .| |||.|. .|. .|  
edtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

GTSLNDTMKHVKSRRQCVNPNQGFWKQLITYEGI
|  |... ...| || .|.||.|| ||| ..| .
gwtlkeayeylkerrsivapnrGflkqlakfeel
subfamily_MKPLV_pd Subfamily MKPLV 280-413 3.3e-29 95.5 In-house 26-159 (164) alignment 
Range on Protein: 280-413
Range on HMM: 26-159/164.0
YDHVYLGSEWNASNLEELKENGVEYVLNITKEIDNFFAGTFTYFNIRLWDLEDSNLLPYWDETFKFINQARDKGSKVLVHCKRGISRSASTVIAYGMKEY
 |..|||   .| | . ||.  .....|...|  . |. .. | .... |  |..| .. . . ||. .| | | .||||| .| |||.|. .|. .|  
edtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

GTSLNDTMKHVKSRRQCVNPNQGFWKQLITYEGI
|  |... ...| || .|.||.|| ||| ..| .
gwtlkeayeylkerrsivapnrGflkqlakfeel
0051429 (Phosphotyrosine protein) phosphatases II 280-410 7.3e-17 57.4 In-house 20-220 (272) alignment 
Range on Protein: 280-410
Range on HMM: 20-220/272.0
YDH-VYLGSEW---NASNLEELKENGVEYVLNITKEIDNFFAG------TFTYFNIRLWDLEDSNLLPYW------------------------------
 .. .|... .   .| ... |||.|. .......|    . .       ..|... ..| ..   | ..                              
kpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagea

------------------DETFKFINQARDkGSKVLVHCKRGISRSASTVIAYGMKeYGTS--------------LNDTMKHVKSRRQCVNPNQGFWKQL
                  ..  ..... .| | .|||||. |..|..  | .. .  .| |              | .........| ...........|
revmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylfl

ITY
  .
yea
subfamily_STYXL1_pd Subfamily STYXL1 281-412 8.7e-22 71.0 In-house 17-151 (157) alignment 
Range on Protein: 281-412
Range on HMM: 17-151/157.0
DHVYLGSEWNASNLEELKENGVEYVLNITKEIDNFFAGTFT---YFNIRLWDLEDSNLLPYWDETFKFINQARDKGSKVLVHCKRGISRSASTVIAYGMK
...||| . .| | .  |.  |  ..|.... |...||.      ..|.. | ....||.  .|  .||.. . .|. |||  ..||||||. .||| | 
gklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmy

EYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYEG
.. ..|....|..|  .. |.||..| .||  .| 
skkitlkkaykylkkCkenvkPnrafveqlseWek
0038934 (Phosphotyrosine protein) phosphatases II 281-416 1e-18 63.1 In-house 36-178 (194) alignment 
Range on Protein: 281-416
Range on HMM: 36-178/194.0
DHVYLGSEWNASNLEELKENGVEYVLNITKEIDNFFAGTFTYFNIRLWDLE--DSNLLPYWDETFKFINQA-----RDKGSKVLVHCKRGISRSASTVIA
. .|  | ..  .. .|.  .. .|...|..   . .  |.  .|.  .|   | .  |  . ...|.. .     .|.| .|.|||| |..|..  |.|
eelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa

YGMKEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYEGILNS
| .. .| |... .......|. . |||.....| .. . |..
YLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrk
subfamily_MSG5_pd Subfamily MSG5 282-416 1.2e-20 67.3 In-house 33-162 (165) alignment 
Range on Protein: 282-416
Range on HMM: 33-162/165.0
HVYLGSEwnaSNLEELKEngVEYVLNITKEIDN--FFAGTFTYFNIRlWDlEDSNLLPYWDETFKFINQARDKGSKVLVHCKRGISRSASTVIAYGMKEY
..|| ||    .|.||     . |.|..|||..  .   .  |. |. |.  ||..     .  . |  |. |. |.||||. |.||||| ..|| || |
klylyse...pklkells..fdlvinvakeindlellvpavkyyhie.we.hdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyy

GTSLNDTMKHVKSRRQCVNPNQGFWKQLITYEGILNS
. ||.|. ...||. . ..|. |.  ||. .| .|. 
nlslrdaydklksvaddispsiglifqlmewevalsk
DSPc Dual specificity phosphatase, catalytic domain 283-411 1.5e-35 117.0 Pfam-A 1-131 (133) alignment 
Range on Protein: 283-411
Range on HMM: 1-131/133.0
VYLGSEWNASnLEELKENGVEYVLNITKEIDN---FFAGTFTYFNIRLWDLEDSNLLPYWDETFKFINQARDKGSKVLVHCKRGISRSASTVIAYGMKEY
.||||. .|| |. |...|...|.|.|||..|   .  . ..|..| . | ..... .. .|. .||..|..|| ||||||. ||||||. .||| ||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GTSLNDTMKHVKSRRQCVNPNQGFWKQLITYE
. |||. ...||.||....|| ||..||. ||
nlslneAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 283-411 1.5e-35 117.0 In-house 1-131 (133) alignment 
Range on Protein: 283-411
Range on HMM: 1-131/133.0
VYLGSEWNASnLEELKENGVEYVLNITKEIDN---FFAGTFTYFNIRLWDLEDSNLLPYWDETFKFINQARDKGSKVLVHCKRGISRSASTVIAYGMKEY
.||||. .|| |. |...|...|.|.|||..|   .  . ..|..| . | ..... .. .|. .||..|..|| ||||||. ||||||. .||| ||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GTSLNDTMKHVKSRRQCVNPNQGFWKQLITYE
. |||. ...||.||....|| ||..||. ||
nlslneAyefvkerrskispnagflrqLleye
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 283-413 2.3e-17 56.4 In-house 6-140 (145) alignment 
Range on Protein: 283-413
Range on HMM: 6-140/145.0
VYLGSEWNASNLEELKENGVEYVLNITKE----IDNFFAGTFTYFNIRLWDLEDSNLLPYWDETFKFINQARDKGSKVLVHCKRGISRSASTVIAYGMKE
.| ||  .|...  |.| |.  ..|..       ..  .  .. . |   |||  .|  ..||   ||.. ...|. |.|||  |.||| .  .|. || 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

YGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYEGI
 . .| .. . |.|.|    ||  | |.|.  |  
cnmtlseaarqvrsnrllaypnvtflknllnlekq
subfamily_PTPMT1_pd Subfamily PTPMT1 292-413 6.4e-17 56.5 In-house 36-167 (171) alignment 
Range on Protein: 292-413
Range on HMM: 36-167/171.0
SNLEEL-KENGVEYVLNITKEID---------NFFAGTFTYFNIRLWDLEDSNLLPYWDETFKFINQARDKGSKVLVHCKRGISRSASTVIAYGMKEYGT
|  .|| ... |. |.....| .         ..     ...... .|  ..  |    .. .||.. ..||..| |||| | .|||. |..| ||..  
slikeLiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkekl

SLNDTMKHVKSRRQCVNPNQGFWKQLITYEGI
|... .|..|..|. .. ..  ||.|  ||  
speeAlkalkkkRkiirlakkqwkalqeyeek
0040438 (Phosphotyrosine protein) phosphatases II 294-411 1.9e-23 78.7 In-house 103-272 (317) alignment 
Range on Protein: 294-411
Range on HMM: 103-272/317.0
LEELKENGVEYVLNITKEIDN---------------------------FFAGTFTYFNIRLWDL----------------EDSNLLPYWDETFKFINQAR
.. ..|.||......|.. ..                           .  . .|.......||                 | .. |..|. ..|....|
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

DK----GSKVLVHCKRGISRSASTVIAYGM-----KEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYE
..    |..|||||. |..|... ..|| |     ||.| .. ...|.....| .. .. .....|....
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydal
0039614 (Phosphotyrosine protein) phosphatases II 294-411 8.8e-20 66.8 In-house 118-285 (297) alignment 
Range on Protein: 294-411
Range on HMM: 118-285/297.0
LEELKENGVEYVLNITKEIDN--------------------FFAGTFTYFNIRLWDL-------------------EDSNLLPYWDETFKFINQARD---
.. ..|.||......||....                     . ..... .. .. |                    | .  |. .  ..|....|.   
wrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

---KGSKVLVHCKRGISRSASTVIAYGM-----KEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYE
   || .|||||. |..|... ..|| |     ||.| .. ...|.....| .. .. .....|. ..
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydal
0043336 (Phosphotyrosine protein) phosphatases II 295-410 3.8e-16 54.8 In-house 106-272 (278) alignment 
Range on Protein: 295-410
Range on HMM: 106-272/278.0
EELKENGVEYVLNITKEIDN------------------------------------------FFAGTFTYFNIRLWDLEDSNLLPYWDETFKFINQARD-
. ..|.||. ....|.. ..                                              ..|   .   .  | .. .  .  ..|....|. 
rmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrea

---KGSKVLVHCKRGISRSASTVIAYGM-----KEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITY
   ....|||||. |..|..  ...| .     ||.| .| ...|.....| .  ... ....|. .
ledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
subfamily_DSP23_pd Subfamily DSP23 295-395 3e-07 25.2 In-house 25-126 (148) alignment 
Range on Protein: 295-395
Range on HMM: 25-126/148.0
EELKENGVEYVLNITKEIDNFFAG--TFTYFNIRLWDLEDSNlLPYWDETFKFINQARDKGSKVLVHCKRGISRSASTVIAYGMKEYGTSLNDTMKHVKS
. | ..|| |.. .|.|         . |. ..|. |      |   .|  . ...| .|.  | ||| .|  |. . .  | .|| . .  ...  |. 
rylldlgvrylvslteegrphveatpnltlvrlriddyhppa.leqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrr

RRQ
.| 
lrp
0047943 (Phosphotyrosine protein) phosphatases II 297-408 2.8e-14 48.7 In-house 97-265 (273) alignment 
Range on Protein: 297-408
Range on HMM: 97-265/273.0
LKENGVEYVLNITKEIDNFFAGTFTYFNIRL----------------------------------------------WDLEDSNLLPYWDETFKFINQAR
..|..|...  .|.....     . |.                                                   .  | .  |.... ..||...|
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

D------KGSKVLVHCKRGISRSASTVIAYGM-----KEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLI
.      ....|.|||. |..|... .... .     ||.| .. ...|...|.| .. ..  ....|.
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfly
0051299 (Phosphotyrosine protein) phosphatases II 297-400 9.5e-13 43.7 In-house 112-271 (288) alignment 
Range on Protein: 297-400
Range on HMM: 112-271/288.0
LKENGVEYVLNITKEIDNFF---------------------------AGTFTYFNIRLW--------------------DLEDSNLLPYWDETFKFINQA
. |..|...  .||....                              ...|......                     .  | .  ..... ..|....
vweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlv

RDK----GSKVLVHCKRGISRSASTVIAYGM-----KEYGTSLNDTMKHVKSRRQCVNPN
|..    |. |.|||. |..|..  .... .     ||.| .. ...|.....| .. ..
rkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqt
0050432 (Phosphotyrosine protein) phosphatases II 297-400 1.7e-12 42.8 In-house 128-284 (308) alignment 
Range on Protein: 297-400
Range on HMM: 128-284/308.0
LKENGVEYVLNITKEIDNFFAGTFTYFNIRLW----------------------------------------------DLEDSNLLPYWDETFKFINQAR
. |..|...  .||...|     . |.   |                                               . .| .  |.... ..|....|
vweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvr

DK--GSKVLVHCKRGISRSASTVIAYGM-----KEYGTSLNDTMKHVKSRRQCVNPN
..  |....|||. |..|..  .... .     ||.| .. ...|.....| .. ..
kslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqt
0046845 (Phosphotyrosine protein) phosphatases II 298-397 1.3e-10 36.6 In-house 145-256 (284) alignment 
Range on Protein: 298-397
Range on HMM: 145-256/284.0
KENGVEYVLNITKEIDNFFAGTFTYFNIRLWDleDSNLLPYWDETFKFINQARDK------GSKVLVHCKRGISRSASTVIAYGMKEY--------GTSL
|.. . ..| .|..  . .  | |.| .  |   | .  |. .  ..|....|.       |....|||. |..|..  .... ..|.        | ..
kddytvrtleltnlgytgesrtvthfhytswp..dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdv

NDTMKHVKSRRQCV
 ...|.....| . 
leavkrlreqRpgm