Gene STYX in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily STYX
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP022_AA protein Get Run
NvecP022_AA_31-183 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0044763 (Phosphotyrosine protein) phosphatases II 22-181 1.2e-38 127.9 In-house 11-172 (178) alignment 
Range on Protein: 22-181
Range on HMM: 11-172/178.0
DIADWTYSKRREMQEIVPGIFLGPYSAAmkSKLEHLKSQGITHIVCIRQNIEANFVK--PNFPN--DFLYLVLDVADTTTENIIRYFPQVKAFVDDCV-S
 . .. .|    . ||.||..||.. .|  . || || .||||||......| .|.|  | .|   .. || . . | .. .....|... .|..... .
nleglersdyinaseilpglylgslppa..ddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealde

KGGKVLVHGNAGISRSAALMIAYIMETYGLAYREAFLFVQQRRFcINPNEGFTQQLMEYEPIYLA
|||.|||| .||..||..|..||.| ..|| . ||. .|..||. |.||.|. .||.|.|...|.
kggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk
subfamily_STYX_pd Subfamily STYX 23-188 3.7e-105 342.1 In-house 1-166 (166) alignment 
Range on Protein: 23-188
Range on HMM: 1-166/166.0
IADWTYSKRREMQEIVPGIFLGPYSAAMKSKLEHLKSQGITHIVCIRQNIEANFVKPNFPNDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVSKGGKVL
|..||||||||||||.||.||||||||||||||.||..|||||||||||||||..|||||..|.||||||||.|.||||||.|.||.|.||...||||||
ieewtyskrremqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvl

VHGNAGISRSAALMIAYIMETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYEPIYLANYQAKQQ
|||||||||||||.||||||||||.|||||..||.|||||||||||..||.|||.||||....|..
vhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiylakltikll
0045450 (Phosphotyrosine protein) phosphatases II 23-180 2e-27 92.2 In-house 22-304 (307) alignment 
Range on Protein: 23-180
Range on HMM: 22-304/307.0
IADWTYSKRREMQEIVPGIF--LGPYSAAMKSK-------------------------------------------------------------------
..|. .  ..|......     ||.||.|.. .                                                                   
lldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetve

--LEHLKSQGITHIVCIRQNIEA-----------------------NFVKPNFPNDFLYLVLDVADT-----------------TTENIIRYFPQVKAFV
  .. |. ||.|.||.... .|                        .... .  ... ...| | |.                    ..  .| .. .|.
dFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfi

DDCVS------KGGKVLVHGNAGISRSAALMIAYIMETYG--------LAYREAFLFVQQRRFCINPNEGFTQQLMEYEPIYL
. . .      |||.|||| .||..|......||.| ...        . ..||. .....| .. .|... ..|.|..  .|
eevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
PTEN_1 23-183 7.9e-25 82.8 In-house 30-195 (196) alignment 
Range on Protein: 23-183
Range on HMM: 30-195/196.0
IADWTYSKRREMQEIVPGIFLGPYSAAmKSKLEHLKSQGITHIVCIRQNIEA----NFVKPNFPNDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVS--
||..  . |  .||| .| ..|... .  . |..||..|||..|.     |        .  | ... || ... | .. .. . |  .| | . . |  
iamgkapsrpllqeideglyrgslkdv.aadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdp

KGGKVLVHGNAGISRSAALMIAYIMETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYEPIYLANY
.|..||||  ||..||. . .|| |....| ..||. .|...| ...|| .. ..|.||.   ||..
ngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellaek
0036941 (Phosphotyrosine protein) phosphatases II 25-186 1.6e-24 82.1 In-house 10-283 (297) alignment 
Range on Protein: 25-186
Range on HMM: 10-283/297.0
DWTYSKRREMQEIVPGIFLGPYSAAMKSKLEH--------------------------------------------------------LKSQGITHIVCI
.... ...|..|..| ..||..|.|.. .  .                                                        .  |..|.||..
lflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvml

RQNIEANFVK-----PNF---------------------PNDFLYLVLDVAD----------------TTTENIIRYFPQVKAFVDDCVS------KGGK
 . .| ...|     |.                       .|. . .| | |                    ..  .. .. .|.. . .      .||.
telvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggp

VLVHGNAGISRSAALMIAYIM--------ETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYEPIYLANYQAK
|||| .||..||... .|..|        ...|. . ||.... ..|... ..... ..| |..  .| ..  |
vlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltk
0051429 (Phosphotyrosine protein) phosphatases II 26-184 1.9e-20 69.1 In-house 15-229 (272) alignment 
Range on Protein: 26-184
Range on HMM: 15-229/272.0
WtyskrreMQEIVPG-IFLGPYS-AAMKSKLEHLKSQGITHIVCIRQNIEANFVK-PNFPNDFLYLVLDVADTTTENIIRYF------------------
.        ....|| ......   .    ...||..||..||..|.  | ...| . .. .. ||.|.. |.... |  ..                  
y.......grvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilre

------------------------------PQVKAFVDDCVSkGGKVLVHGNAGISRSAALMIAYIMEtYGLA--------------YREAFLFVQQRRF
                               ....... . . ||.|||| .||..|.. .  ....  .|.               ..||   ....| 
llltlllsagearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrp

CINPNEGFTQQLMEYEPIYLANYQ
.....|.. ..|.|..  .| ...
gavqteeqylflyeallellrsll
0041856 (Phosphotyrosine protein) phosphatases II 27-184 5e-31 103.1 In-house 12-177 (182) alignment 
Range on Protein: 27-184
Range on HMM: 12-177/182.0
TYSKRREMQEIVPGIFLGPYSA------------AMKSKLEHLKSQGITHIVCIRqnieanfV-----KPNFPNDFLYLVLDVADTTTENiiryFPQVKA
 |   | . .| ....||.. |             . . |. ||..|||.||...             .    . . || | . | .. .    .... .
pydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.......eelywpellerlgiqylylpwpDhgvpd....ldelld

FVDDCVSKGGKVLVHGNAGISRSAALMIAYIMETYGLAYREAFLFVQQRRF--CINPNEGFTQQLMEYEPIYLANYQ
|.... ..||.|||| .||..|...| .||.|...|. ..||. .|..||.  .|.|| .|  ||...| ..| ...
fieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkktr
0049772 (Phosphotyrosine protein) phosphatases II 27-190 1.3e-30 102.6 In-house 112-284 (314) alignment 
Range on Protein: 27-190
Range on HMM: 112-284/314.0
TYSKRREMQEIVPGI------------------------FLGPYSAAMKSKLEHLKsqgithivcirqniEANFVKPNFPND-FLYLVLDVADtTTENII
... | ... .....                        . |...    . ||.||              |  . .. |..  . || ..| |  .....
rmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk..............eelydpelferlgikylripvpD.gsapll

RYFPQVKAFVDDCvSKGGKVLVHGNAGISRSA-ALMIAYIMETYGLAYREAFLFVQQRRFcINPNEGFTQQLMEYEPIYLANYQAKQQIA
..|... .|.... .|||.|||| .||..|.. .. .||.|  .|. ..||. .|...|. ||||.|| .||..|| |. | ... . . 
edfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefilealleylkflk
0040439 (Phosphotyrosine protein) phosphatases II 28-180 2.1e-27 91.7 In-house 23-246 (249) alignment 
Range on Protein: 28-180
Range on HMM: 23-246/249.0
YSKRREMQEIVPGIFLGPYSAAMKSKL----------------------EHLKSQGITHIVCIRQNIEANFVKP--------------------------
|   |   .|.|| ||. |  |   ..                      . |. .|||.||....  | ...|                           
ydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkd

------------NFPNDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVS------KGGKVLVHGNAGISRSAALMIAYIM-----ETYGLAYREAFLFVQ
             ..... .|.. . |    ..  .|... .|.. . .      |||.|||| .||..|.... .||.|     ...|. . ||. ...
dytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllr

QRRFCINPNEGFTQQLMEYEPIYL
..|... .|... ..|.|..  .|
sqRpgavqnpeqyrflyeallell
subfamily_DSP6_pd Subfamily DSP6 29-176 1.1e-31 103.5 In-house 9-151 (158) alignment 
Range on Protein: 29-176
Range on HMM: 9-151/158.0
SKRREMQEIVPGIFLGPYSAAmkSKLEHLKSQGITHIVCIRQNIEANFVKPnfpNDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVSKGGKVLVHGNAG
....   ||.| ..||   .|  |.|| ||  .| ... . .|..  | .    ... || . . |  ..|. ..||.  .|.|.  ||  |||||  ||
aeaefpveilpllylGsakda..snlevlkklkikyvlnvtsnlpnkfees...gelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaG

ISRSAALMIAYIMETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYE
|||| ....||.|... |.  .|. .|..|.  | ||  | .||...|
isrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfe
subfamily_DSP10_pd Subfamily DSP10 30-177 1.6e-31 103.3 In-house 10-151 (159) alignment 
Range on Protein: 30-177
Range on HMM: 10-151/159.0
KRREMQEIVPGIFLGPYSAAmkSKLEHLKSQGITHIVCIRQNIEANFVKpnfpNDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVSKGGKVLVHGNAGI
.  .. ...| .|||    |  ..|. |.  .||... . ...  .| .    ... |  ..| ||...|. .|| .  .|...  .|| .|||| .|||
etapasqvlpfLflGsekda..adldaldrlnitavlnvttsvPnefee....ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGi

SRSAALMIAYIMETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYEP
||||...|||.|.  .|. ..|. ||...|  | || .|  ||.|.| 
srsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefek
subfamily_DSP3_pd Subfamily DSP3 31-176 3.9e-31 101.9 In-house 8-154 (162) alignment 
Range on Protein: 31-176
Range on HMM: 8-154/162.0
RREMQEIVPGIFLGPYSAAMKSklEHLKSQGITHIVCIRQNiE--ANFVKPNFPN--DFLYLVLDVADTTTENIIRYFPQVKAFVDDCVSK-GGKVLVHG
 .|..|. |....|  ..|..   ..||  ||||..   .  .      ...| .  .. || |.| |. . .. .|| .. .|.|. .|.  |||||| 
skevdevypklyvgdeavakdk..skLkklGithvlnaaeg.rfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhc

NAGISRSAALMIAYIMETYGLAYREAFLFVQQRRfCINPNEGFTQQLMEYE
..|.||||.|..||.| .  ..  ||   |...| .| ||||| .||.|..
vvGvsRsatlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeld
subfamily_DSP19_pd Subfamily DSP19 32-177 1.1e-39 130.2 In-house 10-148 (152) alignment 
Range on Protein: 32-177
Range on HMM: 10-148/152.0
REMQEIVPGIFLGPYSAAMKskLEHLKSQGITHIVCIRQNIEANfvkpnFPNDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVSKGGKVLVHGNAGISR
 |..|. | ..||  ..|..   | ||...||||. .  ...       ||.|| || ... |.  .....|....  |...  || | |||| |||.||
levgeveprlylgsqdvaad..keilkekkitHilnvatgvpnv.....fpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSR

SAALMIAYIMETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYEP
||...|||.|..  | ..||.  |.. | ||.|||||..|| ||| 
sasvviaylmkkeelsleealelvrearpcikPneGFikqLkeyea
subfamily_DSP14_pd Subfamily DSP14 32-178 2.2e-33 109.4 In-house 5-143 (157) alignment 
Range on Protein: 32-178
Range on HMM: 5-143/157.0
REMQEIVPGIFLGPYSAAMKsklEHLKSQGITHIVCIRQnieaNFVKPNFpNDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVSKGGKVLVHGNAGISR
... .|.| .||. ..|  |   | ||...||.|. . .    . ..... .|. .. . |.|...... ..| .| . ...   ||||.|||  ||.||
aalsqitpsLflsgvaalsk...ellkkkkitliinvtv....elpntkl.kdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSR

SAALMIAYIMETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYEPI
||.|..||.|..  |. |||.  |...|  |.|| || .||..||  
SAslclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkk
PTPc_motif_SM00404 33-176 4.4e-42 138.3 In-house 1-138 (140) alignment 
Range on Protein: 33-176
Range on HMM: 1-138/140.0
EMQEIVPGIFLGPYSAAMksKLEHLKSQGITHIVCIRQNIEANfvkpNFPNDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVSKGGKVLVHGNAGISRS
|...| |...|| .|.|.  ... ||. ||||.... ......    .  ..| .| ... |...... .|...|..|.... .||||||||  ||.|||
epsrilphlylgskskaq..npallkklgithvinvteevslt....kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRS

AALMIAYIMETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYE
|.|.|||.|....| ..||. ||..|| .|.||..|..||.|||
atliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieye
subfamily_Slingshot_pd Subfamily Slingshot 33-189 3.7e-34 111.5 In-house 18-167 (169) alignment 
Range on Protein: 33-189
Range on HMM: 18-167/169.0
EMQEIVPGIFLGPYSAAmkSKLEHLKSQGITHIVCIRQNIEaNFvkpnFPNDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVSKGGKVLVHGNAGISRS
.  .|   ..||    |  |.||.||..|...|. . ..|. ||    ||..| || . | |. ......|. .   |.. . .|| |||||   |.|||
saskifdhvylGsewna..snleelkengveyilnvtkeid.nf....fpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrs

AALMIAYIMETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYEPIYLANYQAKQQI
|. .||| | .||| . ||. .|..|| .|.||.||..|| ||| |  |. | ....
astviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGileaskqrhnkl
0046846 (Phosphotyrosine protein) phosphatases II 33-181 2.8e-32 107.3 In-house 11-174 (176) alignment 
Range on Protein: 33-181
Range on HMM: 11-174/176.0
EMQEIVPGIFLGPYSAA--------MKSKLEHLKSQGITHIVCIRQNIEANFVK-PNFPND-----FLYLVLDVADTTTENIiRYFPQVKAFVDDCVSKG
 . .|.....||.. .|        . . ||.||..|||..|.. . .| ...| ||....     . ||.|.. | .. .. ...... .|.......|
dldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeg

GKVLVHGNAGISRSAALMIAYIMET-YGLAYREAFLFVQQRRF-CINPNEGFTQQLMEYEPIYLA
|.||||  |||.|...| .||..|. .|| . ||. .|...|. .. ..... ..|.|.|  .| 
gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellllk
subfamily_DSP8_pd Subfamily DSP8 33-176 2.6e-31 102.3 In-house 14-151 (159) alignment 
Range on Protein: 33-176
Range on HMM: 14-151/159.0
EMQEIVPGIFLGPYSAAMKSKLehLKSQGITHIVcirqNIEANFVKPNFPNDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVSKGGKVLVHGNAGISRS
....|.. ..||    .....|  |. .||....    |.. . .|... ..  .| . | |. .|... .|..   |.| ..|. |.||||  ||||||
gptrilknlylGsqkdvlseel..lsklgisyvl....nasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrs

AALMIAYIMETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYE
|...||||| |  ... ||. ||...|  |.||  | .||.|||
atvaiayimktlemsldeayrfvkekrptispnlnflgqLleye
subfamily_DSP15_pd Subfamily DSP15 34-185 1.5e-36 119.8 In-house 2-145 (151) alignment 
Range on Protein: 34-185
Range on HMM: 2-145/151.0
MQEIVPGIFLGPYSAAMKSklEHLKSQGITHIVCIRQnieanFVKPnFPNDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVSKGGKVLVHGNAGISRSA
.....||..|| .  . ..  | || . ||||. . .       |. . .|. |... ..||.  .. ..| .   |. .| .|...||||  ||.|||.
iskvlpglylgnfrdskde..elLkeknithilsvhd.....nakk.llkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsv

ALMIAYIMETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYEPIYLANYQA
 |..||.|    | .|.|. .....|.. ||| || .||.|||   |..|. 
tlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklkeyrk
0048076 (Phosphotyrosine protein) phosphatases II 34-179 1.7e-34 113.9 In-house 4-142 (145) alignment 
Range on Protein: 34-179
Range on HMM: 4-142/145.0
MQEIVPGIFLGPYSAAMKskLEHLKSQGITHIVCIrqnieANFVKPNFPNDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVSKGGKVLVHGNAGISRSA
..||.||..||.. .|..  ||.||. |||.....     ..  .  ..... || |.. | .. ......... .|.......||.|||| .||..|..
pseilpglylgslptald..lellkdlgittvlnl.....tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtg

ALMIAYIMETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYEPIY
.|..||.| ..|. . ||. .|...|....||.|. ..|.|.| ..
tlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 34-177 4.1e-34 112.7 In-house 4-142 (144) alignment 
Range on Protein: 34-177
Range on HMM: 4-142/144.0
MQEIVPGIFLGPYSAAMKskLEHLKSQGITHIVCIRQNIEANFVKPNfpnDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVSKGGKVLVHGNAGISRSA
. ||.||..||.. .|..  ||.||..|||...... . | .|....    . || |.. |  . ... ..... .|.......||.|||| .||..|..
pseilpglylgslptald..lellkklgittvinlteeyepeflere...giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtg

ALMIAYIMETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYEP
.|..||.| ..|| . ||. .|..||....||.|. ..|.|||.
tlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
subfamily_DSP12_pd Subfamily DSP12 34-179 8.6e-34 111.2 In-house 2-143 (155) alignment 
Range on Protein: 34-179
Range on HMM: 2-143/155.0
MQEIVPGIFLGPYSAAMKSklEHLKSQGITHIVCIRQNIEANFVKPNFPNDflYLVLDVADTTTENIIRYFPQVKAFVDDCVSKGGKVLVHGNAGISRSA
...| ||..||  .|...   |.||. .|||.. . ..   .. . .   .  .. ....|. .|.|....... .|........|.|||| .||.|||.
vsrilpglylggleavqee..ellkelkithvlsvikeelpehklkkgkvs..tkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSv

ALMIAYIMETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYEPIY
...|||.| ...|   .|. .|.. .  |.||||| .||  .| . 
tiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmg
0051082 (Phosphotyrosine protein) phosphatases II 34-175 4.9e-21 70.3 In-house 8-149 (151) alignment 
Range on Protein: 34-175
Range on HMM: 8-149/151.0
MQEIVPGIFLGPYSaaMKSKLEHLKSQGITHIVCIRQNIEANFVKPNFPN-DFLYLVLDVADTTTENIIRYFPQVKAFVDDCVSK-GGKVLVHGNAGISR
.  . .|.... .   .   || ||..||..||..|.  | .. .  .|. .. .| . . |... ..  .|..|..|.. . .| .|.|||| .||..|
fsyvtgglyrsggp..ladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgR

SAALMIAYIMEtYGLAYREAFLFVQQRRF-CINPNEGFTQQLMEY
...|...|.|  .|. . ||. .....|. ...||..|  ||...
TGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_DSP1_pd Subfamily DSP1 35-178 1.1e-39 130.1 In-house 19-155 (163) alignment 
Range on Protein: 35-178
Range on HMM: 19-155/163.0
QEIVPGIFLGpySAAMKSKLEHLKSQGITHIVCIRQNIEANFVKpnfpnDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVSKGGKVLVHGNAGISRSAA
..|.. ..||  |.   |.|| |||.|||.|. . ....  | .      | |  | . |.....|  .| .|  |.|.. .|.||||.| .||||||..
ekildfLylG..setvasnleiLkslgitailnvskeldnvfed.....lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsst

LMIAYIMETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYEPI
|..||.|.|  . . ||| ||.||| .|.|| ||..||..||  
lclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekk
subfamily_LRR-DSP_pd Subfamily LRR-DSP 35-176 2e-35 116.2 In-house 121-255 (263) alignment 
Range on Protein: 35-176
Range on HMM: 121-255/263.0
QEIVPGIFLGPYSAAMKSKLehLKSQGITHIVCIRqnieANfVKPNFPNDFLYLVL-DVADTTTENIIRYFPQVKAFVDDCVSKGGkVLVHGNAGISRSA
.||....|||   .|.   .  ||..|.|||.       |. ..| ||. | ||.. |. |.   .| ..| .. ||...   ||| ||||  ||.|||.
deiidklflGgldsannksi..lkdlgvthillav....ad.fePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrss

ALMIAYIMETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYE
.|.|.|.|    | ..||. .|...|  |.|| || .||. ||
tlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkye
0036282 (Phosphotyrosine protein) phosphatases II 35-176 1.6e-24 82.0 In-house 13-166 (174) alignment 
Range on Protein: 35-176
Range on HMM: 13-166/174.0
QEIVPGIFLGPYSAAmksKLEHLKSQGITHIVCIRQNIEAN----------FVKPNFPNDFLYLVLDVADTTTENIIRyFPQVKAFVDDCVSK--GGKVL
 .| |....| . .|    .| ||..|||..|. .. .| .          . .   .... || | . | .. ..   . ..  ||....|.  ||.||
syitprliagqgpla...fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvl

VHGNAGISRSAALMIAYIMETYGL-AYREAFLFVQQRR---FCINPNEGFTQQLMEYE
|| .||..|...|..||.|....|  ...|. .|...|    .. ..... ..| ..|
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfe
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 36-176 4.9e-26 85.0 In-house 9-144 (148) alignment 
Range on Protein: 36-176
Range on HMM: 9-144/148.0
EIVPG-IFLGpySAAMKSKLEHLKSQGITHIVCIRQNIEANFVKPnfpnDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVSKGGKVLVHGNAGISRSAA
|| .. .|||  |  ....|| ||  |.|.||   .. .  . .        || . ..|   |..  .|... |||.  ...|..|||| . |.|||.|
eikdafLFlG..skksaadlealkalgvtrivnatkerdnaldqr....gieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssa

LMIAYIMETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYE
| .......   . .||. .|...|  ..|| || .|| |.|
lallwlidfkrvslkealalvkskrryvdpnlgfLkqLaele
subfamily_STYXL1_pd Subfamily STYXL1 36-177 1.1e-20 67.4 In-house 13-151 (157) alignment 
Range on Protein: 36-177
Range on HMM: 13-151/157.0
EIVPG-IFLGPYSAAMKSKLE-HLKSQGITHIVCIRQNieanfVKPNFPNDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVSKGGKVLVHGNAGISRSA
|..|| ..|| |. |.. ...  || ..  ..    ..     .    ..    | ..| |.   ...  . ..  |... . .|  ||| .| ||||||
evlPgklylGnykqaqnpaikkdlkvkahvnvsmdadk.....liagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsa

ALMIAYIMETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYEP
|..|||.|  . .....|. .... .  ..|| .| .|| |.| 
aviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWek
subfamily_PTPMT1_pd Subfamily PTPMT1 36-178 2.3e-14 48.2 In-house 22-167 (171) alignment 
Range on Protein: 36-178
Range on HMM: 22-167/171.0
EIVPGIFLGPYSaaMKSKLEHL-KSQGITHIVCIRQNIE----ANFVKPNFPNDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVSKGGKVLVHGNAGIS
 |   ..||     ..|. ..| ... .  .|..... |    || ..    ..  .| | . | | .  .    .   |...  ||| .| || .|| .
riDdtvilGalP..frslikeLiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrg

RSAALMIAYIMETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYEPI
|||.| ..|.| .. |   ||  .....|  |. ..   ..| |||  
RsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeek
DSPc Dual specificity phosphatase, catalytic domain 41-176 2.8e-38 125.8 Pfam-A 1-131 (133) alignment 
Range on Protein: 41-176
Range on HMM: 1-131/133.0
IFLGPYSAAMkskLEHLKSQGITHIVCIRQNIEANfvkpNF--PNDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVSKGGKVLVHGNAGISRSAALMIA
..|| .|.|.   |. |. .|||... . .....|    |.  .... || . | |.|...| ........|.... .||.||||| .|||||||.|.||
lylgskstas...lalleklgitlvinvtkevpnn....naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliia

YIMETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYE
|.|.|..| ..||. ||..|| .|.||.||..||.|||
YlmktknlslneAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 41-176 2.8e-38 125.8 In-house 1-131 (133) alignment 
Range on Protein: 41-176
Range on HMM: 1-131/133.0
IFLGPYSAAMkskLEHLKSQGITHIVCIRQNIEANfvkpNF--PNDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVSKGGKVLVHGNAGISRSAALMIA
..|| .|.|.   |. |. .|||... . .....|    |.  .... || . | |.|...| ........|.... .||.||||| .|||||||.|.||
lylgskstas...lalleklgitlvinvtkevpnn....naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliia

YIMETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYE
|.|.|..| ..||. ||..|| .|.||.||..||.|||
YlmktknlslneAyefvkerrskispnagflrqLleye
0043147 (Phosphotyrosine protein) phosphatases II 41-181 2e-30 101.1 In-house 24-162 (172) alignment 
Range on Protein: 41-181
Range on HMM: 24-162/172.0
IFLGPYSAAMKSKLEHLKSQGITHIVCIRQNieANFVKPNFPNDFLYLVLDVADTTTEnIIRYFPQVKAFVDD--CVSKGGKVLVHGNAGISRSAALMIA
...||..  . . .. ||..||||||.. .    .  .. ..... || | . | ..  ........  |.|.  ..|.||.||||  ||..|...| .|
atqgplrntladfwrmlkelgithivnltel..lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaa

YIMEtYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYEPIYLA
|.|. .|| . ||. .|...|... .|... ..|...| ..| 
ylml.lglsleeavalvrekRpgavqnpsqyrflyyfekllll
0049260 (Phosphotyrosine protein) phosphatases II 41-177 6e-30 99.3 In-house 13-147 (152) alignment 
Range on Protein: 41-177
Range on HMM: 13-147/152.0
IFLGPYSAAMKSKLEHLKSQGITHIVCIRQNIEanFVKPNFPNDFLYLVLDVADTTTENIIRYFPQVKAFVDD-CVSKGGKVLVHGNAGISRSAALMIAY
...||..  ... .. ||..|||.||.. .  |  . |. ... . || | . | .. ... .....  |..  . .|||.||||  ||..|...|..||
atqgpgpntladfwrmlkelgittivmltelle..lgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaay

IMEtYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYEP
.|. .|. . ||. .|...| ...||.|. ..|.|.| 
lml.lgvsleeavalvrekRpgavpnpgqlrflyefek
0045098 (Phosphotyrosine protein) phosphatases II 41-181 2.9e-28 94.5 In-house 29-273 (278) alignment 
Range on Protein: 41-181
Range on HMM: 29-273/278.0
IFL---------------------------------------GPYSAAMKSKLEHLKSQGITHIVCIRQNIEA---------------------------
..|                                       ||    . . .. |...|||.||.. . .|                            
lylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllse

--------------------NFVKPNFPNDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVS--------------KGGKVLVHGNAGISRSAALMIAYI
                    .  .... . . ||  .  .. ...|...| ..  |......              .||.|||| .||..|...| .||.
evlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaayl

METY---GLAYREAFLFVQQRRFC-INPNEGFTQQLMEYEPIYLA
| ..   |. . ||. .....| . . .|... ..|.|..  .| 
mlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 41-176 3.9e-26 85.3 In-house 10-149 (154) alignment 
Range on Protein: 41-176
Range on HMM: 10-149/154.0
IFLGPYSAAMKSkLeHLKSQGITHIVCIRQNIEANFVKPNF----PNDFLYLVLDVADTTTENIIRYFPQVKAFVDDCV--SKGGKVLVHGNAGISRSAA
.... . ||.   |  |. . |..|. .   |.  | . |        . || |.. | .  .||. . ..  |.|| .   . .||||| ..|.|||||
lyissfdaalnk.l.dlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaa

LMIAYIMETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYE
|.|.|.|.   ... .|. .... |. |.||.|| .||  .|
llisylmdklkislslalellkdsryiikPnqGflkqleife
0047943 (Phosphotyrosine protein) phosphatases II 44-174 1.1e-13 46.7 In-house 84-266 (273) alignment 
Range on Protein: 44-174
Range on HMM: 84-266/273.0
GPYSAAMKSKLEHLKSQGITHIVCIRQNIEANF-------------------------VKPNFPNDFLYLVLDVAD-------------------TTTEN
|| .  ... .  .. |....||.. . .| .                          .. .  .|.   .| . .                     .  
gPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvpp

IIRYFPQVKAFVDDCVS---KGGKVLVHGNAGISRSAALMIAYIM-----ETYGLAYREAFLFVQQRRFCINPNEGFTQQLME
 . .. .   .|... .   ..|.|.|| .||..|.... .....     ...|. . ||. .....|... ... . ..|.|
slesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflye
0050432 (Phosphotyrosine protein) phosphatases II 44-167 3.4e-11 38.5 In-house 115-286 (308) alignment 
Range on Protein: 44-167
Range on HMM: 115-286/308.0
GPYSAAMKSKLEHLKSQGITHIVCIRQNIEANFVKP--NFPND-----------------------FL-------------------YLVLDVADTTTEN
||..  ...    .  |....||.. . .| . .|    .|..                       .                    .  ..  |  . .
gPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPp

IIRYFPQVKAFVDDCVsKGGKVLVHGNAGISRSAALMIAYIM-----ETYGLAYREAFLFVQQRRFCINPNEG
 .. . .   .|...  .||...|| .||..|.... .....     ...|. . ||. .. ..| .  ... 
speilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe
0037934 (Phosphotyrosine protein) phosphatases II 45-179 3.8e-25 84.3 In-house 52-241 (243) alignment 
Range on Protein: 45-179
Range on HMM: 52-241/243.0
PYSAAMKS----KLEHLKSQGITHIVCIRQNIEANFV----------------------------------------KPNFPNDFLYLVLDVAD----TT
| .   ..     .. |...|||.||.... .| . .                                        .. . ... |. | . |    ..
PlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPds

TENIIRYFPQVKAFVDD-----CVSKGGKVLVHGNAGISRSAALMIAYIMETY-GLAYREAFLFVQQRRFC-INPNEGFTQQLMEYEPIY
.|...... .|..|...     . ..||.||||  ||..|...| .||.| .. |. . ||. .....|.. . ..... ..|.|..  .
pedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeallel
0040438 (Phosphotyrosine protein) phosphatases II 45-183 2.5e-23 78.3 In-house 94-279 (317) alignment 
Range on Protein: 45-183
Range on HMM: 94-279/317.0
PYSAAMKSKLEHLKSQGITHIVCIRQNIEA----------------------NFVKPNFPNDFLYLVLDVADT----------------TTENIIRYFPQ
| .  . . .. .. ||.|.||.. .  |                       ....    ... ...| | |.                .  ..  .. .
PlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdl

VKAFVDDCVSK----GGKVLVHGNAGISRSAALMIAYIM-----ETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYEPIYLANY
. .|.. . ..    ||.|||| .||..|.... .||.|     ...|. . ||. .....| .. ..... ..|....  || ..
lldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
0038934 (Phosphotyrosine protein) phosphatases II 49-180 3e-15 51.8 In-house 42-177 (194) alignment 
Range on Protein: 49-180
Range on HMM: 42-177/194.0
AMKSKLEHLKSQGITHIVCIRQNIEANFVKPNFP--NDFLYLVLDVAD----TTTENIIRYFPQVKAFVDDcvSKGGKVLVHGNAGISRSAALMIAYIME
.... .. ||...  .   |. . .  .  |.    ... || | . |     ..|.. |..  |. |...  ..||.|.||  ||..|.. | .||...
spedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflne..dpggvvaVHCkaGlgRtGtlvaaYLiy

TYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYEPIYL
..|. ..||  .....|  . || .. ..|...   . 
rlgmsaeeAialfrekRpgaipnqdyleallkrykelr
0042113 (Phosphotyrosine protein) phosphatases II 50-180 3.6e-24 80.9 In-house 61-243 (245) alignment 
Range on Protein: 50-180
Range on HMM: 61-243/245.0
MKSKLE----HLKSQGITHIVCIRQNIEANF-----------------------------------------VKPNFPNDFLYLVLDVADTTTENIIRYF
... .|     |...|||.||....  | ..                                          ..   ... |. |.. | .. ......
lpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllell

PQVKAFVDDCVS--KGGKVLVHGNAGISRSAALMIAYIM-----ETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYEPIYL
 ..  ||.....  ..|.|||| .||..|......||.|     ...|.   ||. .....| .. ..... ..|.|..  .|
ldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 51-176 9.2e-14 44.8 In-house 14-138 (145) alignment 
Range on Protein: 51-176
Range on HMM: 14-138/145.0
KSKLEHLKSQGITHIVCIRQNiEANFVKPNFPNDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVSKGGKVLVHGNAGISRSAALMIAYIMETYGLAYRE
 ...  |.  ||. || .    ..   .    ...  |..   |  . .. ..| .|  |.|    .|  |.||  ||.||| .. .|..|   ...  |
andvptlqelgisrivnmaag.slvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlse

AFLFVQQRRFCINPNEGFTQQLMEYE
|   |. .|.   ||  | ..|.. |
aarqvrsnrllaypnvtflknllnle
subfamily_CDC14_pd Subfamily CDC14 51-156 1.3e-08 29.1 In-house 202-301 (328) alignment 
Range on Protein: 51-156
Range on HMM: 202-301/328.0
KSKLEHLKSQGITHIVCIRQNI--EANFVKPNFPNDFLYLVlDvADTTTENIIRYFPQVkafVDDCvskGGKVLVHGNAGISRSAALMIAYIMETYGLAY
.. ||. .....|..| . ...  . .| .  |    |. . |   | ...|.. | ..   ....    |.. ||  ||. |  .|. .|.|..|... 
eklleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffi.D.GstPsdaivkkflei...aeka...eGaiavhCkaGLGrtGtLiacylmkhyrfta

REAFLFVQ
 ||  ...
aeaiawlr
0039614 (Phosphotyrosine protein) phosphatases II 53-182 7.8e-23 76.8 In-house 117-291 (297) alignment 
Range on Protein: 53-182
Range on HMM: 117-291/297.0
KLEHLKSQGITHIVCIRQNIEA--------------------NFVKPNFPNDFL-----------------YLVLDVADTTTENIIRYFPQVKAFVDDCV
 .. .. ||.|.||.. . .|                     ...|    ...                  .....  | .. ...... ..  .|....
FwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreal

S---KGGKVLVHGNAGISRSAALMIAYIM-----ETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYEPIYLAN
.   |||.|||| .||..|.... .||.|     ...|. . ||. .....| .. ..... ..|....  .| .
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0046845 (Phosphotyrosine protein) phosphatases II 53-181 1e-12 43.5 In-house 93-269 (284) alignment 
Range on Protein: 53-181
Range on HMM: 93-269/284.0
KLEHLKSQGITHIVCIRQNIEANF-----------------------VKPNFPNDFLYLVLDVADTT------------------------TENIIRYFP
    .  |....||.. . .| .                        .. .  .|. . .| . ..                         .|...... 
FwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflr

QVKAFVDDcVSKGGKVLVHGNAGISRSAALMIAYIMETY--------GLAYREAFLFVQQRRfcinpnEGFTQQLMEYEPIYLA
.|. . .. ...||...||  ||..|.... ..... ..        |. . ||. .. ..|       |. |.|. |. .| |
lvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqR......pgmvqtleqyrfvyea
0043336 (Phosphotyrosine protein) phosphatases II 54-179 1.5e-17 59.4 In-house 105-276 (278) alignment 
Range on Protein: 54-179
Range on HMM: 105-276/278.0
LEHLKSQGITHIVCIRQNIEANF----------------------------------------VKPNFPNDFLYLVLDVADTTTE-NIIRYFPQVKAFVD
 . .. .|.|.||....  | .                                          ...      |  |.. | ..  ..  ..  .||. .
wrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavre

DCVSKGGKVLVHGNAGISRSAALMIAYIM-----ETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYEPIY
 . ...|.|||| .||..|.......|..      ..|. . ||. .....|... ... . ..| |..  |
aledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_MKPLT_pd Subfamily MKPLT 55-180 9.5e-29 94.0 In-house 41-161 (164) alignment 
Range on Protein: 55-180
Range on HMM: 41-161/164.0
EHLKSQGITHIVCIRQNIeanfvKPNFPNDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVSKGGKVLVHGNAGISRSAALMIAYIMETYGLAYREAFLF
..||   ||||| . |.      | .||. . || ..| |...|... .. ... |. | .  ||.|||| . | |||..  .|....  |  ..||. .
kvlkdlkithivnvsqek.....kdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayey

VQQRRFCINPNEGFTQQLMEYEPIYL
...|| ...|| || .|| ..| . |
lkerrsivapnrGflkqlakfeelil
subfamily_MKPLV_pd Subfamily MKPLV 55-180 9.5e-29 94.0 In-house 41-161 (164) alignment 
Range on Protein: 55-180
Range on HMM: 41-161/164.0
EHLKSQGITHIVCIRQNIeanfvKPNFPNDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVSKGGKVLVHGNAGISRSAALMIAYIMETYGLAYREAFLF
..||   ||||| . |.      | .||. . || ..| |...|... .. ... |. | .  ||.|||| . | |||..  .|....  |  ..||. .
kvlkdlkithivnvsqek.....kdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayey

VQQRRFCINPNEGFTQQLMEYEPIYL
...|| ...|| || .|| ..| . |
lkerrsivapnrGflkqlakfeelil
0051299 (Phosphotyrosine protein) phosphatases II 56-166 5.2e-12 41.3 In-house 111-272 (288) alignment 
Range on Protein: 56-166
Range on HMM: 111-272/288.0
HLKSQGITHIVCIRQNIEAN----------------------FVKPNFPNDFLYLVLDVADT-----------------------TTEN-IIRYFPQVKA
 .  |....||.. . .| .                      ...    .|. . .| | ..                        . . .  ..  ...
mvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrl

FVDDCVSKGGKVLVHGNAGISRSAALMIAYIM-----ETYGLAYREAFLFVQQRRFCINPNE
. . . |.|| |.|| .||..|.... .....     ...|. . ||. .. ..|... ...
vrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
subfamily_Laforin_pd Subfamily Laforin 70-159 4.8e-10 32.6 In-house 62-151 (183) alignment 
Range on Protein: 70-159
Range on HMM: 62-151/183.0
QNIEANFVKPNFPNDFLYLVLDVADTTTENIIRYFPQVKAFVDDCVSKGGKVLVHGNAGISRSAALMIAYIMETYGLAYREAFLFVQQRR
.|.   ..|    . . |. | . | .||. .. .||   ..   . || .| || |||. ||.|..  ...   | . .    |.  .|
enlpitlkklykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakr
subfamily_MSG5_pd Subfamily MSG5 95-178 3.9e-18 59.1 In-house 76-159 (165) alignment 
Range on Protein: 95-178
Range on HMM: 76-159/165.0
TTTENIIRYFPQVKAFVDDCVSKGGKVLVHGNAGISRSAALMIAYIMETYGLAYREAFLFVQQRRFCINPNEGFTQQLMEYEPI
. . .|.. ....   .    ||. |.||| . |.||||.|..||||  |.|. |.|.  .. .   |.|. |.  ||||.| .
ehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweva
0048567 (Phosphotyrosine protein) phosphatases II 95-165 5.7e-08 27.3 In-house 51-126 (157) alignment 
Range on Protein: 95-165
Range on HMM: 51-126/157.0
TTTENIIRYFPQVKAFVDDCVSKGGKVLVHGNAGI---SRSAALMIAYIMETYGLAYREAFLFVQQRR--FCINPN
 .   ..|.. ... | ...  .|... ||  ||    .|.| |. .|..  .|.  .||. .... |  . . . 
lnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrd
PTPc_DSPc_SM00012 96-142 2.7e-06 22.9 In-house 19-63 (105) alignment 
Range on Protein: 96-142
Range on HMM: 19-63/105.0
TtENIIRYFPQVKAFVDDCVSkGGKVLVHGNAGISRSAALMIAYIME
. ..|.... .|| .  .. | .. |.||  ||..|.. .. ..|. 
s.dsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldill