Gene STYXL1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily STYXL1
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP023_AA protein Get Run
NvecP023_AA_143-301 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 33-122 1.1e-10 34.0 Pfam-A 14-112 (113) alignment
Range on Protein: 33-122
Range on HMM: 14-112/113.0
LLLLDTRKRNEYNESHIITSKFAPR------------NDIGAFTVPYDAELETKIHVVVYDsnttSTKDKGSPALS--CAKLLWEMGSRnQVKVVKGGYE
..|||.|. .||...||  .   |             ...      .  .|. . .||||.    ....... | .  .|..| |.|   .|.|..||.|
vvllDvRspeeyakghIpgAvnvpldslyprrdlffkdklaeeleesgkkldkdktvvvyc....rsgnrsggaaalllalilkelgyk.nvyvLdGGfe

EFSA
...|
awka

subfamily_MKPLT_pd Subfamily MKPLT 127-300 7.1e-31 100.9 In-house 2-163 (164) alignment
Range on Protein: 127-300
Range on HMM: 2-163/164.0
LRTQKIMYTPRELDTLITYPVEVLPSFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELSaDSIilgvddkhvsQVLTIAVEDENKADLLTHMKEAVQ
| |.. ..  ..   . .||  ||.  || |  |...|. . ||||..  |||. |  .  .  |.          . |.. |||| .  | .... | .
LitdldvrdeeDykrikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafp.ksv..........eYlqvkvedesdeqlssfleraak

FIDDHkTNDGRCVLIFSNLGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQLFGK
|. |   . | .||.  . | ||| .|.. .|. ||.  ||.||. | . |  ..||| |. ||...|| ..||
flada.idsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelilGk

subfamily_MKPLV_pd Subfamily MKPLV 127-300 7.1e-31 100.9 In-house 2-163 (164) alignment
Range on Protein: 127-300
Range on HMM: 2-163/164.0
LRTQKIMYTPRELDTLITYPVEVLPSFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELSaDSIilgvddkhvsQVLTIAVEDENKADLLTHMKEAVQ
| |.. ..  ..   . .||  ||.  || |  |...|. . ||||..  |||. |  .  .  |.          . |.. |||| .  | .... | .
LitdldvrdeeDykrikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafp.ksv..........eYlqvkvedesdeqlssfleraak

FIDDHkTNDGRCVLIFSNLGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQLFGK
|. |   . | .||.  . | ||| .|.. .|. ||.  ||.||. | . |  ..||| |. ||...|| ..||
flada.idsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelilGk

0044763 (Phosphotyrosine protein) phosphatases II 135-299 2.1e-29 97.8 In-house 12-172 (178) alignment
Range on Protein: 135-299
Range on HMM: 12-172/178.0
TPRELDTLITYPVEVLPSfLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKElsADSIILGVDDKHVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKTN
 .... .  ....|.||  ||.|.. ......  |.|.... ||.| |        . .    ...  |.| | ..| .  ||| |. |.|.||...  .
leglersdyinaseilpg.lylgslppaddlellkelgithivnlteelelg..flkcdpywpeeagiqylhipipDhgvpdllehflefvefieealde

DGRCVLIFSNLGISRSVTVAIGYLMWSKKISLKDAYSQLHKCREnMQPNRAFIEQLSQWEEQLFG
.|..||.  . |..|| |... |||.. ..|| .|.......|  ..||. ...|| ..|..|..
kggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk

subfamily_STYXL1_pd Subfamily STYXL1 136-301 9.3e-79 256.1 In-house 1-157 (157) alignment
Range on Protein: 136-301
Range on HMM: 1-157/157.0
PRELDTLITYPVEVLPSFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKelsadsIILGVDDkhVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKTnD
|||||.|.||||||||..||.|.|||.||.||.|||||||||||.|.|||      .| ||.|  |...|.|||||||.||||...|||||||..||. .
preldelktyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadk......liagvad..vakllhiavedeneadllerlkeavqfiekhkk.e

GRCVLIFSNLGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQLFGKT
|..||.||| |||||..|.|.|||.||||.||.||..|.||.||..|||||.||||.||.||.|.|
gevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqllget

subfamily_DSP1_pd Subfamily DSP1 138-298 6.7e-31 101.6 In-house 8-157 (163) alignment
Range on Protein: 138-298
Range on HMM: 8-157/163.0
ELDTLITY-PVEVLPSFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELSAdsiilgvddkhVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDG
.||.| .| ||| .  |||.|. ... |. | |.|.. | .||. | |.               . .  .. .||..|||. ....|...|||. |...|
dldklklydPvekildfLylGsetvasnleiLkslgitailnvskeldnvfed...........lfeYkklkleDspkadislvfeeviefidevkkknG

RcVLIFSNLGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQLF
. |||  . ||||| |. . |||..|..||..|.   .. |. ..|| .|. || ..|..| 
k.vlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll

0041856 (Phosphotyrosine protein) phosphatases II 139-302 1.2e-19 66.0 In-house 17-177 (182) alignment
Range on Protein: 139-302
Range on HMM: 17-177/182.0
LdtlitYPVEVLPSfLYIGTYKQ--------------SQNKAITKDLKVKAHVNVTmeadkelsADSIILGVDDKHVSQVLTIAVEDENKADllthMKEA
.     .. ..... ||.| ...               ..    |.|.... ||.|         .        ... |.| . ..| .  |    . |.
r.....dldyInan.lylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywpellerlgiqylylpwpDhgvpd....ldel

VQFIDDHKTnDGRCVLIFSNLGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRE--NMQPNRAFIEQLSQWEEQLFGKTI
..||.. .  .|..||.  . |..|. |... |||.....|| .|.... ..|     .||  |..||  .|..|..||.
ldfieevle.eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkktr

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 142-295 4.7e-27 88.3 In-house 3-145 (148) alignment
Range on Protein: 142-295
Range on HMM: 3-145/148.0
LITYPVEVLPSFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELSADsiilgvddkhVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKtNDGRCVLI
| |.| |. ..||..|  |.  .    |.| | . || | | |. |               . | .|..|..| || .  .....|.. .| ..|| ||.
LrtfpseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqr..........gieYlhvaldDkpkedlsaiFediiafvrkak.deGrrvLv

FSNLGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEE
  ..|.|||  .|. .|.  |..|||.|.   .  |. ..||  |..|| ..|.
hlqmGvsrssalallwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq

subfamily_DSP6_pd Subfamily DSP6 144-297 9.5e-32 103.7 In-house 12-154 (158) alignment
Range on Protein: 144-297
Range on HMM: 12-154/158.0
TYPVEVLPsFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELSADSIIlgvddkhvsQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDGrCVLIFS
..|||.|| .||.|. |...|  . |.||.|  .||| . ..    .  .         . | |..||. ...| ... ||..|||. ....   ||.  
efpveilp.llylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgel.........kylqipiedhlsqnlakffPeaiefidearskks.kvlvhC

NLGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQL
  ||||||||.. ||| ....||.|||  ..| . |. ||  |..|| ..|..|
laGisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl

subfamily_DSP10_pd Subfamily DSP10 145-297 7.3e-28 91.4 In-house 13-153 (159) alignment
Range on Protein: 145-297
Range on HMM: 13-153/159.0
YPVEVLpSFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELSADSIilgvddkhvsQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNdGRCVLIFSN
  ..|| .||..|  |....... . |...| .||| .  .| . ...          .   | |.| .| .| ....||..||.. . . |. ||.  .
pasqvl.pfLflGsekdaadldaldrlnitavlnvttsvPnefeeeal..........kYkripvsDtskqnlkqyfeealefieearkk.gsrvLvhCq

LGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQL
 |||||.||.|.|||  ...||.|||   ...|  . || .|. || ..|..|
aGisrsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekel

0048076 (Phosphotyrosine protein) phosphatases II 145-298 1.7e-26 88.1 In-house 3-143 (145) alignment
Range on Protein: 145-298
Range on HMM: 3-143/145.0
YPVEVLPSfLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELsadsiilgvddKHVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDgRCVLIFSN
.| |.||. ||.| .   .. .  |||.... .|.|.| . .            ... |.| . ..| .  ||| .. |...||...  .. ..||.. .
wpseilpg.lylgslptaldlellkdlgittvlnltselelle...........rlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCs

LGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQLF
 |..|. |... |||.....|| .|. .....| .. ||  ....| ..|..|.
aGvgRtgtlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefelell

0048179 (Phosphotyrosine protein) phosphatases II 145-297 1.8e-26 88.0 In-house 3-144 (144) alignment
Range on Protein: 145-297
Range on HMM: 3-144/144.0
YPVEVLPSfLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELSADSiilgvddkhVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDgRCVLIFSN
.|.|.||. ||.| .  ... .  |.|.... .|.| | ..|   .          . |.| . ..| .  |||... |...||...  .. ..||.  .
npseilpg.lylgslptaldlellkklgittvinlteeyepeflere.........giqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCs

LGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQL
 |..|. |... |||. ...||..|. .....| .. ||. ....| ..|..|
aGvgRtgtlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekll

PTPc_motif_SM00404 146-295 4.2e-32 106.0 In-house 2-139 (140) alignment
Range on Protein: 146-295
Range on HMM: 2-139/140.0
PVEVLPSfLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKElsadsiilgvDDKHVSQVLTIAVEDENKADLLTHMKEAVQFIDDHkTNDGRCVLIFSNL
| ..||  ||.|.....||.|..| |.... .|||.| ...          . .   |.| | ..|..|..|. .......||..  ...|. ||..  .
psrilph.lylgskskaqnpallkklgithvinvteevslt..........kensgfqilqiplddnekdklskyldkvldfiena.ekkggkvlVHCqa

GISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEE
|.|||.|..| |||.....||..||. ... |....||  |..|| ..|.
GvSRSatliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieyek

subfamily_LRR-DSP_pd Subfamily LRR-DSP 146-299 1.2e-20 67.8 In-house 120-260 (263) alignment
Range on Protein: 146-299
Range on HMM: 120-260/263.0
PVEVLPSfLYIGTYKQSQNKAITKDLKVkAHVNVTMEADKELSADSIilgvddkhvsQVLTI-AVEDENKADLLTHMKEAVQFIDDHKTNDGrcVLIFSN
| |...  |..|. . ..||.| ||| | .|. ...   . |  .            . |.|  .|| ..||.  |..|   ||.. . . |  ||.   
Pdeiidk.lflGgldsannksilkdlgv.thillavadfePlfPklf..........kylsiddiedvdeadisqhfeetnafieeGrkkGG..vlvhcr

LGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQLFG
 |.||| |. | |||  ... .|.|.    | | ..|||. |..|| ..|..|| 
aGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfc

subfamily_DSP19_pd Subfamily DSP19 147-297 4.5e-26 86.0 In-house 12-150 (152) alignment
Range on Protein: 147-297
Range on HMM: 12-150/152.0
VEVLPSFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELSADSiilgvddkhvsQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDGrCVLIFSNLG
| ..   ||.|     ..| | |  |.   .||... ..  . |            ..|.| . |....|||...|||..||.. ...|| .||.  | |
vgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdf...........tylsieilDlpetdllsylkealdFieearskdg.avlvHCnAG

ISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQL
.|||..|.|.||| ....||..|...... | ...||  ||.|| ..|..|
vSRsasvviaylmkkeelsleealelvrearpcikPneGFikqLkeyeael

subfamily_DSP8_pd Subfamily DSP8 148-298 2.6e-24 79.6 In-house 17-155 (159) alignment
Range on Protein: 148-298
Range on HMM: 17-155/159.0
EVLPsFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKelsaDSIIlgvDDKHvsqVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDGRcVLIFSNLGI
..|. .||.|. |.. .. . ..| .   .|. ..  |     . .    ...   .| . |.|... .||  ....|.|||  |...|| ||..   ||
rilk.nlylGsqkdvlseellsklgisyvlnasnscpk....leel...kesk...flrvPvkDkydekllpwfdksvefidkaksengr.vlvhvlaGi

SRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQLF
||| ||||.|.|   ..|| .||  ... |. ..||  |..|| ..|..| 
srsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelk

subfamily_DSP15_pd Subfamily DSP15 148-296 5.5e-22 72.5 In-house 4-138 (151) alignment
Range on Protein: 148-296
Range on HMM: 4-138/151.0
EVLPSfLYIGTYKQSQNKAITKDLKVKAHVNVTMeadkelsadsiilgVDDKHVS--QVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDGRcVLIFSNL
.|||  ||.| ...|....  |. ..   ..|                   |..   . ..||..|  .|.| ...||.|.|| . . ...  ||.   .
kvlpg.lylgnfrdskdeelLkeknithilsvhd..............nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeen.vlvhCla

GISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQ
|.|||||... |||   ... .|| . ....|   .||  | .|| ..|..
GvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt

subfamily_DSP3_pd Subfamily DSP3 148-297 2.1e-21 70.2 In-house 13-157 (162) alignment
Range on Protein: 148-297
Range on HMM: 13-157/162.0
EVLPSfLYIGTYKQSQNKAITKDLKVKAHVNVTMEadKELSADSIILGVDDKHVsQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDGRCVLIFSNLGI
|| |. ||.|  . ...|   | | .   .| .    .  . |      .| .. . | . |.|  ..|| .. ..|..|||.  ...   ||. .. |.
evypk.lyvgdeavakdkskLkklGithvlnaaeg..rfskvdtgaefykdlei.kylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGv

SRSVTVAIGYLMWSKKISLKDAYSQLHKCREnMQPNRAFIEQLSQWEEQL
||| |... ||| ..|..|..| .. .| || ..||. |..|| . .|.|
sRsatlvlayLmirrkmtlveairtvrkkRe.ilPneGFlkqLaeldeel

subfamily_STYX_pd Subfamily STYX 148-296 4.4e-15 49.2 In-house 14-156 (166) alignment
Range on Protein: 148-296
Range on HMM: 14-156/166.0
EVLPSfLYIGTYKQSQNKAItKDLKVKAHVNVtMEADKELSADSIILGVDDKHVSQVLTIAveDENKADLLTHMKEAVQFIDDHKTNDGRcVLIFSNLGI
|.||  |..| |  ...  . . || .    . .   ... |. |    .|.    || .|  |.   ... .. .  .||||   . |. ||.  | ||
eilpg.lflgpysaamkskl.evlkkhgithi.vcirqnieanlikpnfpdrfrylvldva..dntveniirylptvkefiddslqkggk.vlvhgnagi

SRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQ
||| .. |.|.| .  .  ..|.  . . |  ..||  |..|| ..|  
srsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeai

0051429 (Phosphotyrosine protein) phosphatases II 148-298 6.3e-09 31.4 In-house 18-225 (272) alignment
Range on Protein: 148-298
Range on HMM: 18-225/272.0
EVLPSFLYIGTYK---QSQNKAITKDLKVKAHVNVTMEADKELSA-DSIIlgvddkHVSQVLTIAVEDENKADLL-------------------------
.|.| .|| . .      .. .  |.|..|. |... |  ..    |  .      .  ..| . ..|.   . |                         
vvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdryw......pgirylhlpilddsaptilygalrvtllseellldyilrelllt

--------------------------THMKEAVQFIDDhktndGRCVLIFSNLGISRSVTVAIGYLMWsKKIS--------------LKDAYSQLHKCRE
                            ..|..... |     |. ||.  . |..|. ||.  .|.    .|              | .|...| ..| 
lllsagearevmhlhytdwpdhgvpqeallellellld.....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrp

NMQPNRAFIEQLSQWEEQLF
.. .. .....| ... .|.
gavqteeqylflyeallell

PTEN_1 150-297 4.2e-18 60.9 In-house 44-191 (196) alignment
Range on Protein: 150-297
Range on HMM: 44-191/196.0
LPSFLYIGTYKQS-QNKAITKDLKVKAHVNVTMEADKelSADSIILGVDDKHVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKTND-GRCVLIFSNLGI
.. .||.| .|.  ...   |  .. ..||.. | .   |. |  |    |.  ..| . .|| .. .|  .......||.  . .. |..||..   |.
ideglyrgslkdvaadldnlkedgitlvvnlseeeel..sgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGl

SRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQL
.||.||.. |||...| . ..| . . ..| .. || .. |.| . ...|
gRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael

HVSL Uncharacterised conserved protein 151-233 5e-06 12.0 Pfam-A 41-126 (239) alignment
Range on Protein: 151-233
Range on HMM: 41-126/239.0
PSFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADK-ELSADSIILGVDDKHVSQVLTIAVEDENKADLLTHMKEAV--QFIDDHKT
... |. .. ... . . ..|  ..  ..|... . . . || .   .  |.|   |. ...|... .....|.|.  . |  .| 
athvYlewrpskaelellsklisqleslltkleaeidalldsdLgvpkplHiSLSrtlvlrseqrdsfvdslkkalrssnirpfkv

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 152-297 2.6e-27 89.0 In-house 8-152 (154) alignment
Range on Protein: 152-297
Range on HMM: 8-152/154.0
SFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELSADSIilGVDDKHVSQVLTIAVEDENKADLLTHMKEAVQFIDDHK-TNDGRCVLIFSNLGISRS
.||||.... . ||   .  ..|  .|| .  .  .. .     ..|  . . | . . |. . |.. ... | .||||     .   ||. |. |.|||
iflyissfdaalnkldlqlkniksilnvgiGinnlftdens..dindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrs

VTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQL
 ...|.||| ..||||  |.  |...|  ..||. |..|| ..| .|
aallisylmdklkislslalellkdsryiikPnqGflkqleifekel

subfamily_DSP14_pd Subfamily DSP14 152-301 6.7e-26 85.1 In-house 12-148 (157) alignment
Range on Protein: 152-301
Range on HMM: 12-148/157.0
SFLYIGTYKqSQNKAITKDLKVKAHVNVTMEADKeLSADSIIlgvddkhvsqVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDGRcVLIFSNLGISRSV
. |.....  ...|.  |  |. . .|||.|. .  ....|           .. ..|||...|.| .|. |... |.. |...|. .|..   |.||| 
psLflsgva.alskellkkkkitliinvtvelpn.tklkdie..........rvkvpveDnpeaklakhfdevadkieevkkkggk.tlvhCvaGvSRSA

TVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQLFGKT
.... |||  .|.||..||......|  ..||  | .|| ..|..|.||.
slclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgks

0051082 (Phosphotyrosine protein) phosphatases II 152-291 3e-11 38.6 In-house 13-147 (151) alignment
Range on Protein: 152-291
Range on HMM: 13-147/151.0
SFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKElsadsIIL------GvddkhvSQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDGRCVLIFSNL
..||.. .  ... .  |.|..|. ||.. |   .              |       .|| | ..|    .| .. .....|..    ... .||.  . 
gglyrsggpladflellkelgiktivnlrseeerg.....ycpeylpelg......ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsa

GISRSVTVAIGYLMWsKKISLKDAYSQLHKCRE-NMQPNRAFIEQLS
|..|. |... |||   ..|| .|.......|    |||  |. || 
GkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlf

subfamily_Slingshot_pd Subfamily Slingshot 153-296 8.6e-19 61.5 In-house 25-156 (169) alignment
Range on Protein: 153-296
Range on HMM: 25-156/169.0
FLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELSaDSIilgvddkhvsQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDGRcVLIFSNLGISRSVT
..|.|.   . |    |. .|.  .||| | |.  . ...          . |.| | ||...|||.. .|. .||.  |... . ||.   .|.||| .
hvylGsewnasnleelkengveyilnvtkeidnffp.ekf..........eylnirvydeeetdllkywnetykfiekakkkgsk.vlvhckmGvsrsas

VAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQ
. | | | . ..||..|.. ... |. ..||..|..||...|  
tviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGi

0049260 (Phosphotyrosine protein) phosphatases II 153-296 1.3e-18 62.6 In-house 14-148 (152) alignment
Range on Protein: 153-296
Range on HMM: 14-148/152.0
FLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELS--ADSIilgvddkhvsQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDGRCVLIFSNLGISRS
....| .  ....   |.|.... |..| . ..     .  |          |.| . ..| .  ||  .......||. .. ..| .||.    |..|.
tqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRt

VTVAIGYLMWsKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQ
 |... |||. ...||..|.... ..| .. ||  ....| ..|..
gtlvaaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekl

DSPc Dual specificity phosphatase, catalytic domain 154-296 4e-29 96.2 Pfam-A 1-133 (133) alignment
Range on Protein: 154-296
Range on HMM: 1-133/133.0
LYIGTYKQSQnKAITKDLKVKAHVNVTMEADKElsadsiilGVDDKHVSQVLTIAVEDENKADLLTHMKEAVQFIDDHkTNDGRCVLIFSNLGISRSVTV
||.|...... .|....|.... .|||.| ...          . |   . | | ||||.....  ...|||.||..  ...|. ||.  . ||||| |.
lylgskstas.lalleklgitlvinvtkevpnn........naikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatl

AIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQ
.| |||..|..||..||. . . |... ||  |. || ..|..
iiaYlmktknlslneAyefvkerrskispnagflrqLleyerk

DSPc Dual specificity phosphatase, catalytic domain 154-296 4e-29 96.2 In-house 1-133 (133) alignment
Range on Protein: 154-296
Range on HMM: 1-133/133.0
LYIGTYKQSQnKAITKDLKVKAHVNVTMEADKElsadsiilGVDDKHVSQVLTIAVEDENKADLLTHMKEAVQFIDDHkTNDGRCVLIFSNLGISRSVTV
||.|...... .|....|.... .|||.| ...          . |   . | | ||||.....  ...|||.||..  ...|. ||.  . ||||| |.
lylgskstas.lalleklgitlvinvtkevpnn........naikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatl

AIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQ
.| |||..|..||..||. . . |... ||  |. || ..|..
iiaYlmktknlslneAyefvkerrskispnagflrqLleyerk

subfamily_DSP12_pd Subfamily DSP12 154-296 1.2e-27 91.3 In-house 9-142 (155) alignment
Range on Protein: 154-296
Range on HMM: 9-142/155.0
LYIGTYKQSQNKAITKDLKVKAHVNVTMEADkelsaDSIILgvDDKHVSqVLTIAVEDENKADLLTHMKEAVQFIDDHKtNDGRCVLIFSNLGISRSVTV
||.|. .. |...  |.||... . |. |.      ..  |  . ..||  ..| . ||...|.|.|. |||.||..   .... ||.  . |.|||||.
lylggleavqeeellkelkithvlsvikeel.....pehkl..kkgkvs.tkfiqilDepeediLshldeavdFieeal.eeegavlvHCqagvSRSvti

AIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQ
 | ||| ..|.||..|.. ... .....||  |.|||  .|. 
viAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekm

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 154-297 5e-19 61.8 In-house 6-141 (145) alignment
Range on Protein: 154-297
Range on HMM: 6-141/145.0
LYIGTYKQSQNKAITKDLKVKAHVNvtMEADKELSADSIilgvDDKHvSQVLTIAVEDENKADLLTHMKEAVQFIDDHKtNDGRCVLIFSNLGISRSVTV
||.|.  .... .....| .   ||  | | . ......      ..  ..| |. || .  ||  |. |  .|||  | ..|  |..    |.||||||
lyvgsalhandvptlqelgisrivn..maagslvasqel....kses.ieillitaedlesydlsqhfdevtdfidkgk.eegagvfvhcmagvsrsvtv

AIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQL
.. .||   ...| .|  |..  |    ||  |. .| . | ||
svaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekql

0043147 (Phosphotyrosine protein) phosphatases II 154-297 7.4e-19 63.6 In-house 26-160 (172) alignment
Range on Protein: 154-297
Range on HMM: 26-160/172.0
LYIGTYKQSQNKAITKDLKVKAHVNVTmEAdkelsadSIILGVDDKHVSQVLTIAVEDENKAdLLTHMKEAVQFIDD-HKTNDGRCVLIFSNLGISRSVT
.. . .  ... .  |.|.... ||.| |          .     ... |.| . ..| .   || .. |...|||. .  ..| .||.    |..|..|
qgplrntladfwrmlkelgithivnlt.el.......lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgt

VAIGYLMWsKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQL
... |||. ...|| .|.... ..| .. .|  .. .| ..|..|
lvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll

0036282 (Phosphotyrosine protein) phosphatases II 154-297 7.5e-16 53.8 In-house 19-169 (174) alignment
Range on Protein: 154-297
Range on HMM: 19-169/174.0
LYIGTYKQSqNKAITKDLKVKAHVNVTMEADKELSADSI----ILGVDDKHVSQVLTIAVEDENKADLLThMKEAVQFIDDHKTN-DGRCVLIFSNLGIS
|..| .  . . .  |.|.... |... |  ..|               ... |.| . ..| .  || . . |.|.|....  . .|..||.  . |..
liagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvg

RSVTVAIGYLMWSKKI-SLKDAYSQLHKCR---ENMQPNRAFIEQLSQWEEQL
|. |... |||   .. || ||.. ....|    .| ..  ....| ..| .|
RtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll

0037934 (Phosphotyrosine protein) phosphatases II 155-297 1.8e-15 52.6 In-house 47-241 (243) alignment
Range on Protein: 155-297
Range on HMM: 47-241/243.0
YIGTY--------KQSQNKAITKDLKVKAHVNVTMEADKELSADSII----------------------------------LGVDDKHVSQVLTIAVED-
... .        .  ..    ..|.... |..| . ...      .                                  |.   ..| ... ... | 
iatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdh

---ENKADLLTHMKEAVQFIDDH----KTNDGRCVLIFSNLGISRSVTVAIGYLMWSK-KISLKDAYSQLHKCREN-MQPNRAFIEQLSQWEEQL
   .. .||| ...|. .||..     . ..|. ||.    |..|. |... ||| .. ...| .|. .| ..| . . ... ....| ... .|
gvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeallel

0046846 (Phosphotyrosine protein) phosphatases II 161-299 9.5e-18 60.0 In-house 36-174 (176) alignment
Range on Protein: 161-299
Range on HMM: 36-174/176.0
QSQNKAITKDLKVKAHVNVTMEADKELSADSIILGVDDKHVSQVLTIAVEDENKADLlTHMKEAVQFIDDHKTNDgRCVLIFSNLGISRSVTVAIGYLMW
  .. .  |.|...| ||.| | ...      .  .  |.  |.| . ..| .  || ... |...||... ... ..||.    ||.|. |... ||..
ladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaaylle

S-KKISLKDAYSQLHKCRE-NMQPNRAFIEQLSQWEEQLFG
. | .|. .|.... ..|  .. ........| ..| .|..
lekglsveealalvreqRplgavqtpeQyrflyefellllk

subfamily_PTPMT1_pd Subfamily PTPMT1 161-297 3.5e-15 50.9 In-house 35-168 (171) alignment
Range on Protein: 161-297
Range on HMM: 35-168/171.0
QSQNKAITKDLKVKAHVNVTMEADKELSADSIILgvDDKHVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKtNDGRCVLIFSNLGISRSVTVAIGYLMW
.|. | . .. .||| |... | .  . |.|       |.  . |..|. |  .|  | .....|.||.... ..|..| .  . | .|| |... ||| 
rslikeLiekenvkavvslneeyelkalanstee..wkklgveqlqlatvDfteapdleklekgvefiekva.skgkrvYvHCkaGrgRsatlvacylmk

SKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQL
..|.|...| . |.|.|. .. ...  ..|...||.|
keklspeeAlkalkkkRkiirlakkqwkalqeyeekl

0042113 (Phosphotyrosine protein) phosphatases II 197-297 6.1e-14 47.5 In-house 136-242 (245) alignment
Range on Protein: 197-297
Range on HMM: 136-242/245.0
DDKHVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKT-NDGRCVLIFSNLGISRSVTVAIGYLM-----WSKKISLKDAYSQLHKCRENMQPNRAFIEQL
  ..| ... . ..| . .||| .. ....|....   ...  ||. .. |..|. |... |||       ...|| .|. .| ..| .. ..  ....|
esrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrfl

SQWEEQL
 ... .|
yeallel

0049772 (Phosphotyrosine protein) phosphatases II 198-297 6.5e-25 83.9 In-house 177-273 (314) alignment
Range on Protein: 198-297
Range on HMM: 177-273/314.0
DKHVSQVLTIAVEDeNKADLLTHMKEAVQFIDDHktNDGRCVLIFSNLGISRSVT-VAIGYLMWSKKISLKDAYSQLHKCREnMQPNRAFIEQLSQWEEQ
 ... ..| | |.| . |.|| ...|...||...  ..|..||.  . |..|. | |...|||.  ..||..|.......|  ..||. ||||| |.|..
erlgikylripvpD.gsaplledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefi

L
|
l

0040439 (Phosphotyrosine protein) phosphatases II 199-298 7.1e-13 44.2 In-house 137-246 (249) alignment
Range on Protein: 199-298
Range on HMM: 137-246/249.0
KHVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKT-----NDGRCVLIFSNLGISRSVTVAIGYLM-----WSKKISLKDAYSQLHKCRENMQPNRAFIE
. . .|| | . |    ..  .......||.  ..     ..| .||. .. |..|. |... |||     . ....|..|...| ..| .. .|  ...
gesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyr

QLSQWEEQLF
.| ... .|.
flyeallell

0045098 (Phosphotyrosine protein) phosphatases II 200-299 1.9e-15 52.5 In-house 155-273 (278) alignment
Range on Protein: 200-299
Range on HMM: 155-273/278.0
HVSQVLTIAVEDENKADLL--THMKEAVQFIDDHKTN-------------DGRCVLIFSNLGISRSVTVAIGYLMWSK---KISLKDAYSQLHKCREN-M
.| ..  . ..| .  .|   ... |...||...  .             .| .||.  . |..|. |... ||| .    ...| .|...| ..| . .
gvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpgla

QPNRAFIEQLSQWEEQLFG
..|  ....| ... .|. 
vqnleqyrflyefllelll

0039614 (Phosphotyrosine protein) phosphatases II 200-301 1.4e-13 46.5 In-house 184-292 (297) alignment
Range on Protein: 200-301
Range on HMM: 184-292/297.0
HVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKTN--DGRCVLIFSNLGISRSVTVAIGYLM-----WSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQ
.| ... .   | .  ..|... |........  .  .|..||. .. |..|. |... |||       .......|...| ..| .. ..  ....| .
tvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyd

WEEQLFGKT
.. .|. ..
allellkrk

0043336 (Phosphotyrosine protein) phosphatases II 200-294 6.5e-11 37.7 In-house 174-273 (278) alignment
Range on Protein: 200-294
Range on HMM: 174-273/278.0
HVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDGRCVLIFSNLGISRSVTVAIGYLM-----WSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWE
.| ..  ... | .  . |... . .......  ... .||. .. |..|. |... ||.       ....| .|...| ..| .. ..  ....| ...
tvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal





0051299 (Phosphotyrosine protein) phosphatases II 201-285 8.4e-08 27.5 In-house 184-273 (288) alignment
Range on Protein: 201-285
Range on HMM: 184-273/288.0
VSQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDGRCVLIFSNLGISRSVTVAIGYLM-----WSKKISLKDAYSQLHKCRENMQPNRA
| .   ..  | .  | .... . .......  ..| .|.. .. |..|. |... .|.       ..... .|. .| ..| .| ..  
vthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpe

0045450 (Phosphotyrosine protein) phosphatases II 203-298 3.5e-13 45.4 In-house 179-304 (307) alignment
Range on Protein: 203-298
Range on HMM: 179-304/307.0
QVLTIAVEDE-----------------NKADLLTHMKEAVQFIDDHKT-----NDGRCVLIFSNLGISRSVTVAIGYLMWSKK--------ISLKDAYSQ
.|.|. |.|                     .. ....|...||.  ..     ..| .||. .. |..|. |... |||..          ..| .|...
tvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkl

LHKCRENMQPNRAFIEQLSQWEEQLF
| ..| .. .|  ....| ... .|.
lreqRpgavqnpeqyrflyeallell

0038934 (Phosphotyrosine protein) phosphatases II 203-298 1.6e-10 36.4 In-house 81-177 (194) alignment
Range on Protein: 203-298
Range on HMM: 81-177/194.0
QVLTIAVEDENKADLLTHMKEAVQFIDDHKT-NDGRCVLIFSNLGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQLF
..| . ..| . .  |  ... ....|..   . | .|..    |..|. |... ||. . ..|...|.  .  .| .. ||. ..|.| .. ..|.
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelr

0047943 (Phosphotyrosine protein) phosphatases II 203-290 9.2e-09 30.6 In-house 170-264 (273) alignment
Range on Protein: 203-290
Range on HMM: 170-264/273.0
QVLTIAVEDENKADLLTHMKEAVQFIDDHKTN--DGRCVLIFSNLGISRSVTVAIGYLM-----WSKKISLKDAYSQLHKCRENMQPNRAFIEQL
...     | .  . |... | .......  .  ..  |.. .. |..|. |... .|.     . .......|. .| ..| .| ..  ....|
hfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl

0040438 (Phosphotyrosine protein) phosphatases II 204-305 3.4e-12 41.7 In-house 158-283 (317) alignment
Range on Protein: 204-305
Range on HMM: 158-283/317.0
VLTIAVEDE----------------NKADLLTHMKEAVQFIDDHKTN---DGRCVLIFSNLGISRSVTVAIGYLM-----WSKKISLKDAYSQLHKCREN
..|. |||                    ..  .... ..|..  ...   .| .||. .. |..|. |... |||       .......|. .| ..| .
lrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpg

MQPNRAFIEQLSQWEEQLFGKTITDI
. .. .....| ... ... ...|..
avqtpeqyrflydalleylkrkltle

0050432 (Phosphotyrosine protein) phosphatases II 210-284 2.3e-06 22.6 In-house 208-285 (308) alignment
Range on Protein: 210-284
Range on HMM: 208-285/308.0
EDENKADLLTHMKEAVQFIDDHKtnDGRCVLIFSNLGISRSVTVAIGYLM-----WSKKISLKDAYSQLHKCRENMQPNR
.| .  . .... . .......   .|  ... .. |..|. |... .|.     . ..... .|. .| ..| .| .. 
pdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp

0036941 (Phosphotyrosine protein) phosphatases II 212-303 1.7e-12 42.7 In-house 178-282 (297) alignment
Range on Protein: 212-303
Range on HMM: 178-282/297.0
ENKADLLTHMKEAVQFIDDHKT-----NDGRCVLIFSNLGISRSVTVAIGYLM--------WSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQLF
    .. ..... ..||.  ..     ..|  ||. .. |..|| |... .||          .......|. .| ..| .. ..  . ..| ... .|.
wpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

GKTIT
 |. |
kkklt

subfamily_MSG5_pd Subfamily MSG5 216-300 3.1e-12 39.9 In-house 80-163 (165) alignment
Range on Protein: 216-300
Range on HMM: 80-163/165.0
DLLTHMKEAVQFIDDHkTNDGRCVLIFSNLGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQLFGK
 .   . .  . |    |  .. .|.  . |.||| .. . |.|   ..||.||| .|.   ....|.  .| || .||  |  |
kivkdlsrltriihaa.tskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevalskk

0046845 (Phosphotyrosine protein) phosphatases II 217-285 4e-06 21.9 In-house 187-261 (284) alignment
Range on Protein: 217-285
Range on HMM: 187-261/284.0
LLTHMKEAVQFIDDhkTNDGRCVLIFSNLGISRSVTVAIGYLMWSK--------KISLKDAYSQLHKCRENMQPNRA
||. .... .....  ...|  ... .  |..|. |... .|...         .... .|...| ..| .|  . .
lleflrlvrellen..lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle