Gene STYXL1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily STYXL1
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP023_AA protein Get Run
NvecP023_AA_143-301 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 33-122 1.1e-10 34.0 Pfam-A 14-112 (113) alignment 
Range on Protein: 33-122
Range on HMM: 14-112/113.0
LLLLDTRKRNEYNESHIITSKFAPR------------NDIGAFTVPYDAELETKIHVVVYDsnttSTKDKGSPALS--CAKLLWEMGSRnQVKVVKGGYE
..|||.|. .||...||  .   |             ...      .  .|. . .||||.    ....... | .  .|..| |.|   .|.|..||.|
vvllDvRspeeyakghIpgAvnvpldslyprrdlffkdklaeeleesgkkldkdktvvvyc....rsgnrsggaaalllalilkelgyk.nvyvLdGGfe

EFSA
...|
awka
subfamily_MKPLT_pd Subfamily MKPLT 127-300 7.1e-31 100.9 In-house 2-163 (164) alignment 
Range on Protein: 127-300
Range on HMM: 2-163/164.0
LRTQKIMYTPRELDTLITYPVEVLPSFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELSaDSIilgvddkhvsQVLTIAVEDENKADLLTHMKEAVQ
| |.. ..  ..   . .||  ||.  || |  |...|. . ||||..  |||. |  .  .  |.          . |.. |||| .  | .... | .
LitdldvrdeeDykrikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafp.ksv..........eYlqvkvedesdeqlssfleraak

FIDDHkTNDGRCVLIFSNLGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQLFGK
|. |   . | .||.  . | ||| .|.. .|. ||.  ||.||. | . |  ..||| |. ||...|| ..||
flada.idsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelilGk
subfamily_MKPLV_pd Subfamily MKPLV 127-300 7.1e-31 100.9 In-house 2-163 (164) alignment 
Range on Protein: 127-300
Range on HMM: 2-163/164.0
LRTQKIMYTPRELDTLITYPVEVLPSFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELSaDSIilgvddkhvsQVLTIAVEDENKADLLTHMKEAVQ
| |.. ..  ..   . .||  ||.  || |  |...|. . ||||..  |||. |  .  .  |.          . |.. |||| .  | .... | .
LitdldvrdeeDykrikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafp.ksv..........eYlqvkvedesdeqlssfleraak

FIDDHkTNDGRCVLIFSNLGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQLFGK
|. |   . | .||.  . | ||| .|.. .|. ||.  ||.||. | . |  ..||| |. ||...|| ..||
flada.idsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelilGk
0044763 (Phosphotyrosine protein) phosphatases II 135-299 2.1e-29 97.8 In-house 12-172 (178) alignment 
Range on Protein: 135-299
Range on HMM: 12-172/178.0
TPRELDTLITYPVEVLPSfLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKElsADSIILGVDDKHVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKTN
 .... .  ....|.||  ||.|.. ......  |.|.... ||.| |        . .    ...  |.| | ..| .  ||| |. |.|.||...  .
leglersdyinaseilpg.lylgslppaddlellkelgithivnlteelelg..flkcdpywpeeagiqylhipipDhgvpdllehflefvefieealde

DGRCVLIFSNLGISRSVTVAIGYLMWSKKISLKDAYSQLHKCREnMQPNRAFIEQLSQWEEQLFG
.|..||.  . |..|| |... |||.. ..|| .|.......|  ..||. ...|| ..|..|..
kggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk
subfamily_STYXL1_pd Subfamily STYXL1 136-301 9.3e-79 256.1 In-house 1-157 (157) alignment 
Range on Protein: 136-301
Range on HMM: 1-157/157.0
PRELDTLITYPVEVLPSFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKelsadsIILGVDDkhVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKTnD
|||||.|.||||||||..||.|.|||.||.||.|||||||||||.|.|||      .| ||.|  |...|.|||||||.||||...|||||||..||. .
preldelktyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadk......liagvad..vakllhiavedeneadllerlkeavqfiekhkk.e

GRCVLIFSNLGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQLFGKT
|..||.||| |||||..|.|.|||.||||.||.||..|.||.||..|||||.||||.||.||.|.|
gevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqllget
subfamily_DSP1_pd Subfamily DSP1 138-298 6.7e-31 101.6 In-house 8-157 (163) alignment 
Range on Protein: 138-298
Range on HMM: 8-157/163.0
ELDTLITY-PVEVLPSFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELSAdsiilgvddkhVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDG
.||.| .| ||| .  |||.|. ... |. | |.|.. | .||. | |.               . .  .. .||..|||. ....|...|||. |...|
dldklklydPvekildfLylGsetvasnleiLkslgitailnvskeldnvfed...........lfeYkklkleDspkadislvfeeviefidevkkknG

RcVLIFSNLGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQLF
. |||  . ||||| |. . |||..|..||..|.   .. |. ..|| .|. || ..|..| 
k.vlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
0041856 (Phosphotyrosine protein) phosphatases II 139-302 1.2e-19 66.0 In-house 17-177 (182) alignment 
Range on Protein: 139-302
Range on HMM: 17-177/182.0
LdtlitYPVEVLPSfLYIGTYKQ--------------SQNKAITKDLKVKAHVNVTmeadkelsADSIILGVDDKHVSQVLTIAVEDENKADllthMKEA
.     .. ..... ||.| ...               ..    |.|.... ||.|         .        ... |.| . ..| .  |    . |.
r.....dldyInan.lylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywpellerlgiqylylpwpDhgvpd....ldel

VQFIDDHKTnDGRCVLIFSNLGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRE--NMQPNRAFIEQLSQWEEQLFGKTI
..||.. .  .|..||.  . |..|. |... |||.....|| .|.... ..|     .||  |..||  .|..|..||.
ldfieevle.eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 142-295 4.7e-27 88.3 In-house 3-145 (148) alignment 
Range on Protein: 142-295
Range on HMM: 3-145/148.0
LITYPVEVLPSFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELSADsiilgvddkhVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKtNDGRCVLI
| |.| |. ..||..|  |.  .    |.| | . || | | |. |               . | .|..|..| || .  .....|.. .| ..|| ||.
LrtfpseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqr..........gieYlhvaldDkpkedlsaiFediiafvrkak.deGrrvLv

FSNLGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEE
  ..|.|||  .|. .|.  |..|||.|.   .  |. ..||  |..|| ..|.
hlqmGvsrssalallwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
subfamily_DSP6_pd Subfamily DSP6 144-297 9.5e-32 103.7 In-house 12-154 (158) alignment 
Range on Protein: 144-297
Range on HMM: 12-154/158.0
TYPVEVLPsFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELSADSIIlgvddkhvsQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDGrCVLIFS
..|||.|| .||.|. |...|  . |.||.|  .||| . ..    .  .         . | |..||. ...| ... ||..|||. ....   ||.  
efpveilp.llylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgel.........kylqipiedhlsqnlakffPeaiefidearskks.kvlvhC

NLGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQL
  ||||||||.. ||| ....||.|||  ..| . |. ||  |..|| ..|..|
laGisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl
subfamily_DSP10_pd Subfamily DSP10 145-297 7.3e-28 91.4 In-house 13-153 (159) alignment 
Range on Protein: 145-297
Range on HMM: 13-153/159.0
YPVEVLpSFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELSADSIilgvddkhvsQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNdGRCVLIFSN
  ..|| .||..|  |....... . |...| .||| .  .| . ...          .   | |.| .| .| ....||..||.. . . |. ||.  .
pasqvl.pfLflGsekdaadldaldrlnitavlnvttsvPnefeeeal..........kYkripvsDtskqnlkqyfeealefieearkk.gsrvLvhCq

LGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQL
 |||||.||.|.|||  ...||.|||   ...|  . || .|. || ..|..|
aGisrsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekel
0048076 (Phosphotyrosine protein) phosphatases II 145-298 1.7e-26 88.1 In-house 3-143 (145) alignment 
Range on Protein: 145-298
Range on HMM: 3-143/145.0
YPVEVLPSfLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELsadsiilgvddKHVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDgRCVLIFSN
.| |.||. ||.| .   .. .  |||.... .|.|.| . .            ... |.| . ..| .  ||| .. |...||...  .. ..||.. .
wpseilpg.lylgslptaldlellkdlgittvlnltselelle...........rlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCs

LGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQLF
 |..|. |... |||.....|| .|. .....| .. ||  ....| ..|..|.
aGvgRtgtlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefelell
0048179 (Phosphotyrosine protein) phosphatases II 145-297 1.8e-26 88.0 In-house 3-144 (144) alignment 
Range on Protein: 145-297
Range on HMM: 3-144/144.0
YPVEVLPSfLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELSADSiilgvddkhVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDgRCVLIFSN
.|.|.||. ||.| .  ... .  |.|.... .|.| | ..|   .          . |.| . ..| .  |||... |...||...  .. ..||.  .
npseilpg.lylgslptaldlellkklgittvinlteeyepeflere.........giqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCs

LGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQL
 |..|. |... |||. ...||..|. .....| .. ||. ....| ..|..|
aGvgRtgtlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekll
PTPc_motif_SM00404 146-295 4.2e-32 106.0 In-house 2-139 (140) alignment 
Range on Protein: 146-295
Range on HMM: 2-139/140.0
PVEVLPSfLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKElsadsiilgvDDKHVSQVLTIAVEDENKADLLTHMKEAVQFIDDHkTNDGRCVLIFSNL
| ..||  ||.|.....||.|..| |.... .|||.| ...          . .   |.| | ..|..|..|. .......||..  ...|. ||..  .
psrilph.lylgskskaqnpallkklgithvinvteevslt..........kensgfqilqiplddnekdklskyldkvldfiena.ekkggkvlVHCqa

GISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEE
|.|||.|..| |||.....||..||. ... |....||  |..|| ..|.
GvSRSatliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_LRR-DSP_pd Subfamily LRR-DSP 146-299 1.2e-20 67.8 In-house 120-260 (263) alignment 
Range on Protein: 146-299
Range on HMM: 120-260/263.0
PVEVLPSfLYIGTYKQSQNKAITKDLKVkAHVNVTMEADKELSADSIilgvddkhvsQVLTI-AVEDENKADLLTHMKEAVQFIDDHKTNDGrcVLIFSN
| |...  |..|. . ..||.| ||| | .|. ...   . |  .            . |.|  .|| ..||.  |..|   ||.. . . |  ||.   
Pdeiidk.lflGgldsannksilkdlgv.thillavadfePlfPklf..........kylsiddiedvdeadisqhfeetnafieeGrkkGG..vlvhcr

LGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQLFG
 |.||| |. | |||  ... .|.|.    | | ..|||. |..|| ..|..|| 
aGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfc
subfamily_DSP19_pd Subfamily DSP19 147-297 4.5e-26 86.0 In-house 12-150 (152) alignment 
Range on Protein: 147-297
Range on HMM: 12-150/152.0
VEVLPSFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELSADSiilgvddkhvsQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDGrCVLIFSNLG
| ..   ||.|     ..| | |  |.   .||... ..  . |            ..|.| . |....|||...|||..||.. ...|| .||.  | |
vgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdf...........tylsieilDlpetdllsylkealdFieearskdg.avlvHCnAG

ISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQL
.|||..|.|.||| ....||..|...... | ...||  ||.|| ..|..|
vSRsasvviaylmkkeelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP8_pd Subfamily DSP8 148-298 2.6e-24 79.6 In-house 17-155 (159) alignment 
Range on Protein: 148-298
Range on HMM: 17-155/159.0
EVLPsFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKelsaDSIIlgvDDKHvsqVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDGRcVLIFSNLGI
..|. .||.|. |.. .. . ..| .   .|. ..  |     . .    ...   .| . |.|... .||  ....|.|||  |...|| ||..   ||
rilk.nlylGsqkdvlseellsklgisyvlnasnscpk....leel...kesk...flrvPvkDkydekllpwfdksvefidkaksengr.vlvhvlaGi

SRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQLF
||| ||||.|.|   ..|| .||  ... |. ..||  |..|| ..|..| 
srsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelk
subfamily_DSP15_pd Subfamily DSP15 148-296 5.5e-22 72.5 In-house 4-138 (151) alignment 
Range on Protein: 148-296
Range on HMM: 4-138/151.0
EVLPSfLYIGTYKQSQNKAITKDLKVKAHVNVTMeadkelsadsiilgVDDKHVS--QVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDGRcVLIFSNL
.|||  ||.| ...|....  |. ..   ..|                   |..   . ..||..|  .|.| ...||.|.|| . . ...  ||.   .
kvlpg.lylgnfrdskdeelLkeknithilsvhd..............nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeen.vlvhCla

GISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQ
|.|||||... |||   ... .|| . ....|   .||  | .|| ..|..
GvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt
subfamily_DSP3_pd Subfamily DSP3 148-297 2.1e-21 70.2 In-house 13-157 (162) alignment 
Range on Protein: 148-297
Range on HMM: 13-157/162.0
EVLPSfLYIGTYKQSQNKAITKDLKVKAHVNVTMEadKELSADSIILGVDDKHVsQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDGRCVLIFSNLGI
|| |. ||.|  . ...|   | | .   .| .    .  . |      .| .. . | . |.|  ..|| .. ..|..|||.  ...   ||. .. |.
evypk.lyvgdeavakdkskLkklGithvlnaaeg..rfskvdtgaefykdlei.kylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGv

SRSVTVAIGYLMWSKKISLKDAYSQLHKCREnMQPNRAFIEQLSQWEEQL
||| |... ||| ..|..|..| .. .| || ..||. |..|| . .|.|
sRsatlvlayLmirrkmtlveairtvrkkRe.ilPneGFlkqLaeldeel
subfamily_STYX_pd Subfamily STYX 148-296 4.4e-15 49.2 In-house 14-156 (166) alignment 
Range on Protein: 148-296
Range on HMM: 14-156/166.0
EVLPSfLYIGTYKQSQNKAItKDLKVKAHVNVtMEADKELSADSIILGVDDKHVSQVLTIAveDENKADLLTHMKEAVQFIDDHKTNDGRcVLIFSNLGI
|.||  |..| |  ...  . . || .    . .   ... |. |    .|.    || .|  |.   ... .. .  .||||   . |. ||.  | ||
eilpg.lflgpysaamkskl.evlkkhgithi.vcirqnieanlikpnfpdrfrylvldva..dntveniirylptvkefiddslqkggk.vlvhgnagi

SRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQ
||| .. |.|.| .  .  ..|.  . . |  ..||  |..|| ..|  
srsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeai
0051429 (Phosphotyrosine protein) phosphatases II 148-298 6.3e-09 31.4 In-house 18-225 (272) alignment 
Range on Protein: 148-298
Range on HMM: 18-225/272.0
EVLPSFLYIGTYK---QSQNKAITKDLKVKAHVNVTMEADKELSA-DSIIlgvddkHVSQVLTIAVEDENKADLL-------------------------
.|.| .|| . .      .. .  |.|..|. |... |  ..    |  .      .  ..| . ..|.   . |                         
vvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdryw......pgirylhlpilddsaptilygalrvtllseellldyilrelllt

--------------------------THMKEAVQFIDDhktndGRCVLIFSNLGISRSVTVAIGYLMWsKKIS--------------LKDAYSQLHKCRE
                            ..|..... |     |. ||.  . |..|. ||.  .|.    .|              | .|...| ..| 
lllsagearevmhlhytdwpdhgvpqeallellellld.....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrp

NMQPNRAFIEQLSQWEEQLF
.. .. .....| ... .|.
gavqteeqylflyeallell
PTEN_1 150-297 4.2e-18 60.9 In-house 44-191 (196) alignment 
Range on Protein: 150-297
Range on HMM: 44-191/196.0
LPSFLYIGTYKQS-QNKAITKDLKVKAHVNVTMEADKelSADSIILGVDDKHVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKTND-GRCVLIFSNLGI
.. .||.| .|.  ...   |  .. ..||.. | .   |. |  |    |.  ..| . .|| .. .|  .......||.  . .. |..||..   |.
ideglyrgslkdvaadldnlkedgitlvvnlseeeel..sgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGl

SRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQL
.||.||.. |||...| . ..| . . ..| .. || .. |.| . ...|
gRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael
HVSL Uncharacterised conserved protein 151-233 5e-06 12.0 Pfam-A 41-126 (239) alignment 
Range on Protein: 151-233
Range on HMM: 41-126/239.0
PSFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADK-ELSADSIILGVDDKHVSQVLTIAVEDENKADLLTHMKEAV--QFIDDHKT
... |. .. ... . . ..|  ..  ..|... . . . || .   .  |.|   |. ...|... .....|.|.  . |  .| 
athvYlewrpskaelellsklisqleslltkleaeidalldsdLgvpkplHiSLSrtlvlrseqrdsfvdslkkalrssnirpfkv
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 152-297 2.6e-27 89.0 In-house 8-152 (154) alignment 
Range on Protein: 152-297
Range on HMM: 8-152/154.0
SFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELSADSIilGVDDKHVSQVLTIAVEDENKADLLTHMKEAVQFIDDHK-TNDGRCVLIFSNLGISRS
.||||.... . ||   .  ..|  .|| .  .  .. .     ..|  . . | . . |. . |.. ... | .||||     .   ||. |. |.|||
iflyissfdaalnkldlqlkniksilnvgiGinnlftdens..dindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrs

VTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQL
 ...|.||| ..||||  |.  |...|  ..||. |..|| ..| .|
aallisylmdklkislslalellkdsryiikPnqGflkqleifekel
subfamily_DSP14_pd Subfamily DSP14 152-301 6.7e-26 85.1 In-house 12-148 (157) alignment 
Range on Protein: 152-301
Range on HMM: 12-148/157.0
SFLYIGTYKqSQNKAITKDLKVKAHVNVTMEADKeLSADSIIlgvddkhvsqVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDGRcVLIFSNLGISRSV
. |.....  ...|.  |  |. . .|||.|. .  ....|           .. ..|||...|.| .|. |... |.. |...|. .|..   |.||| 
psLflsgva.alskellkkkkitliinvtvelpn.tklkdie..........rvkvpveDnpeaklakhfdevadkieevkkkggk.tlvhCvaGvSRSA

TVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQLFGKT
.... |||  .|.||..||......|  ..||  | .|| ..|..|.||.
slclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgks
0051082 (Phosphotyrosine protein) phosphatases II 152-291 3e-11 38.6 In-house 13-147 (151) alignment 
Range on Protein: 152-291
Range on HMM: 13-147/151.0
SFLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKElsadsIIL------GvddkhvSQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDGRCVLIFSNL
..||.. .  ... .  |.|..|. ||.. |   .              |       .|| | ..|    .| .. .....|..    ... .||.  . 
gglyrsggpladflellkelgiktivnlrseeerg.....ycpeylpelg......ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsa

GISRSVTVAIGYLMWsKKISLKDAYSQLHKCRE-NMQPNRAFIEQLS
|..|. |... |||   ..|| .|.......|    |||  |. || 
GkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlf
subfamily_Slingshot_pd Subfamily Slingshot 153-296 8.6e-19 61.5 In-house 25-156 (169) alignment 
Range on Protein: 153-296
Range on HMM: 25-156/169.0
FLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELSaDSIilgvddkhvsQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDGRcVLIFSNLGISRSVT
..|.|.   . |    |. .|.  .||| | |.  . ...          . |.| | ||...|||.. .|. .||.  |... . ||.   .|.||| .
hvylGsewnasnleelkengveyilnvtkeidnffp.ekf..........eylnirvydeeetdllkywnetykfiekakkkgsk.vlvhckmGvsrsas

VAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQ
. | | | . ..||..|.. ... |. ..||..|..||...|  
tviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGi
0049260 (Phosphotyrosine protein) phosphatases II 153-296 1.3e-18 62.6 In-house 14-148 (152) alignment 
Range on Protein: 153-296
Range on HMM: 14-148/152.0
FLYIGTYKQSQNKAITKDLKVKAHVNVTMEADKELS--ADSIilgvddkhvsQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDGRCVLIFSNLGISRS
....| .  ....   |.|.... |..| . ..     .  |          |.| . ..| .  ||  .......||. .. ..| .||.    |..|.
tqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRt

VTVAIGYLMWsKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQ
 |... |||. ...||..|.... ..| .. ||  ....| ..|..
gtlvaaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekl
DSPc Dual specificity phosphatase, catalytic domain 154-296 4e-29 96.2 Pfam-A 1-133 (133) alignment 
Range on Protein: 154-296
Range on HMM: 1-133/133.0
LYIGTYKQSQnKAITKDLKVKAHVNVTMEADKElsadsiilGVDDKHVSQVLTIAVEDENKADLLTHMKEAVQFIDDHkTNDGRCVLIFSNLGISRSVTV
||.|...... .|....|.... .|||.| ...          . |   . | | ||||.....  ...|||.||..  ...|. ||.  . ||||| |.
lylgskstas.lalleklgitlvinvtkevpnn........naikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatl

AIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQ
.| |||..|..||..||. . . |... ||  |. || ..|..
iiaYlmktknlslneAyefvkerrskispnagflrqLleyerk
DSPc Dual specificity phosphatase, catalytic domain 154-296 4e-29 96.2 In-house 1-133 (133) alignment 
Range on Protein: 154-296
Range on HMM: 1-133/133.0
LYIGTYKQSQnKAITKDLKVKAHVNVTMEADKElsadsiilGVDDKHVSQVLTIAVEDENKADLLTHMKEAVQFIDDHkTNDGRCVLIFSNLGISRSVTV
||.|...... .|....|.... .|||.| ...          . |   . | | ||||.....  ...|||.||..  ...|. ||.  . ||||| |.
lylgskstas.lalleklgitlvinvtkevpnn........naikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatl

AIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQ
.| |||..|..||..||. . . |... ||  |. || ..|..
iiaYlmktknlslneAyefvkerrskispnagflrqLleyerk
subfamily_DSP12_pd Subfamily DSP12 154-296 1.2e-27 91.3 In-house 9-142 (155) alignment 
Range on Protein: 154-296
Range on HMM: 9-142/155.0
LYIGTYKQSQNKAITKDLKVKAHVNVTMEADkelsaDSIILgvDDKHVSqVLTIAVEDENKADLLTHMKEAVQFIDDHKtNDGRCVLIFSNLGISRSVTV
||.|. .. |...  |.||... . |. |.      ..  |  . ..||  ..| . ||...|.|.|. |||.||..   .... ||.  . |.|||||.
lylggleavqeeellkelkithvlsvikeel.....pehkl..kkgkvs.tkfiqilDepeediLshldeavdFieeal.eeegavlvHCqagvSRSvti

AIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQ
 | ||| ..|.||..|.. ... .....||  |.|||  .|. 
viAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekm
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 154-297 5e-19 61.8 In-house 6-141 (145) alignment 
Range on Protein: 154-297
Range on HMM: 6-141/145.0
LYIGTYKQSQNKAITKDLKVKAHVNvtMEADKELSADSIilgvDDKHvSQVLTIAVEDENKADLLTHMKEAVQFIDDHKtNDGRCVLIFSNLGISRSVTV
||.|.  .... .....| .   ||  | | . ......      ..  ..| |. || .  ||  |. |  .|||  | ..|  |..    |.||||||
lyvgsalhandvptlqelgisrivn..maagslvasqel....kses.ieillitaedlesydlsqhfdevtdfidkgk.eegagvfvhcmagvsrsvtv

AIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQL
.. .||   ...| .|  |..  |    ||  |. .| . | ||
svaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekql
0043147 (Phosphotyrosine protein) phosphatases II 154-297 7.4e-19 63.6 In-house 26-160 (172) alignment 
Range on Protein: 154-297
Range on HMM: 26-160/172.0
LYIGTYKQSQNKAITKDLKVKAHVNVTmEAdkelsadSIILGVDDKHVSQVLTIAVEDENKAdLLTHMKEAVQFIDD-HKTNDGRCVLIFSNLGISRSVT
.. . .  ... .  |.|.... ||.| |          .     ... |.| . ..| .   || .. |...|||. .  ..| .||.    |..|..|
qgplrntladfwrmlkelgithivnlt.el.......lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgt

VAIGYLMWsKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQL
... |||. ...|| .|.... ..| .. .|  .. .| ..|..|
lvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
0036282 (Phosphotyrosine protein) phosphatases II 154-297 7.5e-16 53.8 In-house 19-169 (174) alignment 
Range on Protein: 154-297
Range on HMM: 19-169/174.0
LYIGTYKQSqNKAITKDLKVKAHVNVTMEADKELSADSI----ILGVDDKHVSQVLTIAVEDENKADLLThMKEAVQFIDDHKTN-DGRCVLIFSNLGIS
|..| .  . . .  |.|.... |... |  ..|               ... |.| . ..| .  || . . |.|.|....  . .|..||.  . |..
liagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvg

RSVTVAIGYLMWSKKI-SLKDAYSQLHKCR---ENMQPNRAFIEQLSQWEEQL
|. |... |||   .. || ||.. ....|    .| ..  ....| ..| .|
RtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0037934 (Phosphotyrosine protein) phosphatases II 155-297 1.8e-15 52.6 In-house 47-241 (243) alignment 
Range on Protein: 155-297
Range on HMM: 47-241/243.0
YIGTY--------KQSQNKAITKDLKVKAHVNVTMEADKELSADSII----------------------------------LGVDDKHVSQVLTIAVED-
... .        .  ..    ..|.... |..| . ...      .                                  |.   ..| ... ... | 
iatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdh

---ENKADLLTHMKEAVQFIDDH----KTNDGRCVLIFSNLGISRSVTVAIGYLMWSK-KISLKDAYSQLHKCREN-MQPNRAFIEQLSQWEEQL
   .. .||| ...|. .||..     . ..|. ||.    |..|. |... ||| .. ...| .|. .| ..| . . ... ....| ... .|
gvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeallel
0046846 (Phosphotyrosine protein) phosphatases II 161-299 9.5e-18 60.0 In-house 36-174 (176) alignment 
Range on Protein: 161-299
Range on HMM: 36-174/176.0
QSQNKAITKDLKVKAHVNVTMEADKELSADSIILGVDDKHVSQVLTIAVEDENKADLlTHMKEAVQFIDDHKTNDgRCVLIFSNLGISRSVTVAIGYLMW
  .. .  |.|...| ||.| | ...      .  .  |.  |.| . ..| .  || ... |...||... ... ..||.    ||.|. |... ||..
ladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaaylle

S-KKISLKDAYSQLHKCRE-NMQPNRAFIEQLSQWEEQLFG
. | .|. .|.... ..|  .. ........| ..| .|..
lekglsveealalvreqRplgavqtpeQyrflyefellllk
subfamily_PTPMT1_pd Subfamily PTPMT1 161-297 3.5e-15 50.9 In-house 35-168 (171) alignment 
Range on Protein: 161-297
Range on HMM: 35-168/171.0
QSQNKAITKDLKVKAHVNVTMEADKELSADSIILgvDDKHVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKtNDGRCVLIFSNLGISRSVTVAIGYLMW
.|. | . .. .||| |... | .  . |.|       |.  . |..|. |  .|  | .....|.||.... ..|..| .  . | .|| |... ||| 
rslikeLiekenvkavvslneeyelkalanstee..wkklgveqlqlatvDfteapdleklekgvefiekva.skgkrvYvHCkaGrgRsatlvacylmk

SKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQL
..|.|...| . |.|.|. .. ...  ..|...||.|
keklspeeAlkalkkkRkiirlakkqwkalqeyeekl
0042113 (Phosphotyrosine protein) phosphatases II 197-297 6.1e-14 47.5 In-house 136-242 (245) alignment 
Range on Protein: 197-297
Range on HMM: 136-242/245.0
DDKHVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKT-NDGRCVLIFSNLGISRSVTVAIGYLM-----WSKKISLKDAYSQLHKCRENMQPNRAFIEQL
  ..| ... . ..| . .||| .. ....|....   ...  ||. .. |..|. |... |||       ...|| .|. .| ..| .. ..  ....|
esrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrfl

SQWEEQL
 ... .|
yeallel
0049772 (Phosphotyrosine protein) phosphatases II 198-297 6.5e-25 83.9 In-house 177-273 (314) alignment 
Range on Protein: 198-297
Range on HMM: 177-273/314.0
DKHVSQVLTIAVEDeNKADLLTHMKEAVQFIDDHktNDGRCVLIFSNLGISRSVT-VAIGYLMWSKKISLKDAYSQLHKCREnMQPNRAFIEQLSQWEEQ
 ... ..| | |.| . |.|| ...|...||...  ..|..||.  . |..|. | |...|||.  ..||..|.......|  ..||. ||||| |.|..
erlgikylripvpD.gsaplledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefi

L
|
l
0040439 (Phosphotyrosine protein) phosphatases II 199-298 7.1e-13 44.2 In-house 137-246 (249) alignment 
Range on Protein: 199-298
Range on HMM: 137-246/249.0
KHVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKT-----NDGRCVLIFSNLGISRSVTVAIGYLM-----WSKKISLKDAYSQLHKCRENMQPNRAFIE
. . .|| | . |    ..  .......||.  ..     ..| .||. .. |..|. |... |||     . ....|..|...| ..| .. .|  ...
gesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyr

QLSQWEEQLF
.| ... .|.
flyeallell
0045098 (Phosphotyrosine protein) phosphatases II 200-299 1.9e-15 52.5 In-house 155-273 (278) alignment 
Range on Protein: 200-299
Range on HMM: 155-273/278.0
HVSQVLTIAVEDENKADLL--THMKEAVQFIDDHKTN-------------DGRCVLIFSNLGISRSVTVAIGYLMWSK---KISLKDAYSQLHKCREN-M
.| ..  . ..| .  .|   ... |...||...  .             .| .||.  . |..|. |... ||| .    ...| .|...| ..| . .
gvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpgla

QPNRAFIEQLSQWEEQLFG
..|  ....| ... .|. 
vqnleqyrflyefllelll
0039614 (Phosphotyrosine protein) phosphatases II 200-301 1.4e-13 46.5 In-house 184-292 (297) alignment 
Range on Protein: 200-301
Range on HMM: 184-292/297.0
HVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKTN--DGRCVLIFSNLGISRSVTVAIGYLM-----WSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQ
.| ... .   | .  ..|... |........  .  .|..||. .. |..|. |... |||       .......|...| ..| .. ..  ....| .
tvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyd

WEEQLFGKT
.. .|. ..
allellkrk
0043336 (Phosphotyrosine protein) phosphatases II 200-294 6.5e-11 37.7 In-house 174-273 (278) alignment 
Range on Protein: 200-294
Range on HMM: 174-273/278.0
HVSQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDGRCVLIFSNLGISRSVTVAIGYLM-----WSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWE
.| ..  ... | .  . |... . .......  ... .||. .. |..|. |... ||.       ....| .|...| ..| .. ..  ....| ...
tvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
0051299 (Phosphotyrosine protein) phosphatases II 201-285 8.4e-08 27.5 In-house 184-273 (288) alignment 
Range on Protein: 201-285
Range on HMM: 184-273/288.0
VSQVLTIAVEDENKADLLTHMKEAVQFIDDHKTNDGRCVLIFSNLGISRSVTVAIGYLM-----WSKKISLKDAYSQLHKCRENMQPNRA
| .   ..  | .  | .... . .......  ..| .|.. .. |..|. |... .|.       ..... .|. .| ..| .| ..  
vthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpe
0045450 (Phosphotyrosine protein) phosphatases II 203-298 3.5e-13 45.4 In-house 179-304 (307) alignment 
Range on Protein: 203-298
Range on HMM: 179-304/307.0
QVLTIAVEDE-----------------NKADLLTHMKEAVQFIDDHKT-----NDGRCVLIFSNLGISRSVTVAIGYLMWSKK--------ISLKDAYSQ
.|.|. |.|                     .. ....|...||.  ..     ..| .||. .. |..|. |... |||..          ..| .|...
tvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkl

LHKCRENMQPNRAFIEQLSQWEEQLF
| ..| .. .|  ....| ... .|.
lreqRpgavqnpeqyrflyeallell
0038934 (Phosphotyrosine protein) phosphatases II 203-298 1.6e-10 36.4 In-house 81-177 (194) alignment 
Range on Protein: 203-298
Range on HMM: 81-177/194.0
QVLTIAVEDENKADLLTHMKEAVQFIDDHKT-NDGRCVLIFSNLGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQLF
..| . ..| . .  |  ... ....|..   . | .|..    |..|. |... ||. . ..|...|.  .  .| .. ||. ..|.| .. ..|.
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelr
0047943 (Phosphotyrosine protein) phosphatases II 203-290 9.2e-09 30.6 In-house 170-264 (273) alignment 
Range on Protein: 203-290
Range on HMM: 170-264/273.0
QVLTIAVEDENKADLLTHMKEAVQFIDDHKTN--DGRCVLIFSNLGISRSVTVAIGYLM-----WSKKISLKDAYSQLHKCRENMQPNRAFIEQL
...     | .  . |... | .......  .  ..  |.. .. |..|. |... .|.     . .......|. .| ..| .| ..  ....|
hfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0040438 (Phosphotyrosine protein) phosphatases II 204-305 3.4e-12 41.7 In-house 158-283 (317) alignment 
Range on Protein: 204-305
Range on HMM: 158-283/317.0
VLTIAVEDE----------------NKADLLTHMKEAVQFIDDHKTN---DGRCVLIFSNLGISRSVTVAIGYLM-----WSKKISLKDAYSQLHKCREN
..|. |||                    ..  .... ..|..  ...   .| .||. .. |..|. |... |||       .......|. .| ..| .
lrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpg

MQPNRAFIEQLSQWEEQLFGKTITDI
. .. .....| ... ... ...|..
avqtpeqyrflydalleylkrkltle
0050432 (Phosphotyrosine protein) phosphatases II 210-284 2.3e-06 22.6 In-house 208-285 (308) alignment 
Range on Protein: 210-284
Range on HMM: 208-285/308.0
EDENKADLLTHMKEAVQFIDDHKtnDGRCVLIFSNLGISRSVTVAIGYLM-----WSKKISLKDAYSQLHKCRENMQPNR
.| .  . .... . .......   .|  ... .. |..|. |... .|.     . ..... .|. .| ..| .| .. 
pdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
0036941 (Phosphotyrosine protein) phosphatases II 212-303 1.7e-12 42.7 In-house 178-282 (297) alignment 
Range on Protein: 212-303
Range on HMM: 178-282/297.0
ENKADLLTHMKEAVQFIDDHKT-----NDGRCVLIFSNLGISRSVTVAIGYLM--------WSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQLF
    .. ..... ..||.  ..     ..|  ||. .. |..|| |... .||          .......|. .| ..| .. ..  . ..| ... .|.
wpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

GKTIT
 |. |
kkklt
subfamily_MSG5_pd Subfamily MSG5 216-300 3.1e-12 39.9 In-house 80-163 (165) alignment 
Range on Protein: 216-300
Range on HMM: 80-163/165.0
DLLTHMKEAVQFIDDHkTNDGRCVLIFSNLGISRSVTVAIGYLMWSKKISLKDAYSQLHKCRENMQPNRAFIEQLSQWEEQLFGK
 .   . .  . |    |  .. .|.  . |.||| .. . |.|   ..||.||| .|.   ....|.  .| || .||  |  |
kivkdlsrltriihaa.tskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevalskk
0046845 (Phosphotyrosine protein) phosphatases II 217-285 4e-06 21.9 In-house 187-261 (284) alignment 
Range on Protein: 217-285
Range on HMM: 187-261/284.0
LLTHMKEAVQFIDDhkTNDGRCVLIFSNLGISRSVTVAIGYLMWSK--------KISLKDAYSQLHKCRENMQPNRA
||. .... .....  ...|  ... .  |..|. |... .|...         .... .|...| ..| .|  . .
lleflrlvrellen..lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle