Gene Tensin in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily Tensin
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP039_AA protein Get Run
NvecP039_AA_5-195 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0042113 (Phosphotyrosine protein) phosphatases II 6-173 2.1e-30 101.3 In-house 24-238 (245) alignment 
Range on Protein: 6-173
Range on HMM: 24-238/245.0
GRVRHVDHEFDLDLTYI----------TERIIAMSFPGTGLES-----TYRNNLRDVA------------------------------KMLQRKHQDKYM
 ||.  ....|||..||          |...||...| ..         ...... .                               ..|  .| |.|.
trvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddyt

VFNLSER--RYDISKLNHQVLDFGWPDHLAPP-LERLCSIIKSIDSWLKTDPQHVVVVHCKGGKGRTGVVISAYMHF----SKMCSSPEAALDWFAIKRf
|..|.    ..| |. ..... ..|||| .|. || |..... ....|. |....|.|||..|.||||..| ||. .    . .. |.| |....  .| 
vrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqR.

yddkLGGVTQPSQRRYVHYF
     | |. ||| |.....
....pgavqtpsqyrflyea
0043336 (Phosphotyrosine protein) phosphatases II 6-173 2.3e-29 98.1 In-house 60-272 (278) alignment 
Range on Protein: 6-173
Range on HMM: 60-272/278.0
GRVRHVDHEFDLDLTYI----------TERIIAMSFPGTGLESTYRNNLRD----------------------------------VAKMLQRKHQDKYMV
 ||.  . ..|||..||          ....||...| .. .  ... ...                                  . ..|  .|.| |.|
srvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytv

FNLSER--RYDISKLNHQVLDFGWPDHLAP-PLERLCSIIKSIDSWLKtDPQHVVVVHCKGGKGRTGVVISAYMHF----SKMCSSPEAALDWFAIKRfy
..|     ... |.  ...  .||||| .| .|. |....| ....|. |....|.|||..|.||||..| .|. .    .  . ..| |....  .|  
rtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR..

ddkLGGVTQPSQRRYVHYF
    | |. ||| |.....
...pgavqtpsqyrflyea
subfamily_Tensin_pd Subfamily Tensin 7-195 2.3e-105 343.1 In-house 1-189 (189) alignment 
Range on Protein: 7-195
Range on HMM: 1-189/189.0
RVRHVDHEFDLDLTYITERIIAMSFPGTGLESTYRNNLRDVAKMLQRKHQDKYMVFNLSERRYDISKLNHQVLDFGWPDHLAPPLERLCSIIKSIDSWLK
.||.|....|||||||||||||.|||..|||..||.||.||||.|..||.|||.||||||.||||||||..||||||||.|||.||.||||.||.|||||
kvryveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWlk

TDPQHVVVVHCKGGKGRTGVVISAYMHFSKMCSSPEAALDWFAIKRFYDDKLGGVTQPSQRRYVHYFSDYLEGKIKLSSEPMFLHHVIV
.|||.||||||||||||.|||.||||..||...| .||||.||.|||.|||| |.|||||||||.|||..|.|||||.|.|.|||.||.
adpqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkiklnssplflhyvil
subfamily_PTEN_pd Subfamily PTEN 7-179 1.1e-65 216.0 In-house 10-181 (184) alignment 
Range on Protein: 7-179
Range on HMM: 10-181/184.0
RVRHVDHEFDLDLTYITERIIAMSFPGTGLESTYRNNLRDVAKMLQRKHQDKYMVFNL-SERRYDISKLNHQVLDFGWPDHLAPPLERLCSIIKSIDSWL
. |  ....||||.||||.||||..| ..||..|||.|.|| |.|..||.|.|...|| |||.|| .|....|  ..  || .|||| | .|...|..||
kkrfkedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwl

KTDPQHVVVVHCKGGKGRTGVVISAYMHFSKMCSSPEAALDWFAIKRFYDDklGGVTQPSQRRYVHYFSDYLEG
..|...||||||| |||||||.|.||.  |......| ||..|| .|. ..   ||| |||||||.|....|| 
eedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknk..kgvtiPsqrRYveYyekllee
0040438 (Phosphotyrosine protein) phosphatases II 7-176 1.2e-23 79.3 In-house 59-274 (317) alignment 
Range on Protein: 7-176
Range on HMM: 59-274/317.0
RVRHVDHEFDLDLTYI----------TERIIAMSFPGTG-----LESTYRNNLRDVAKMLQRK------------------------------HQDKYMV
||.  . ..|||..||          . ..||...|  .     ..  ...... .  . . .                              . . . .
RVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitl

FNLSER--RYDISKLNHQVLDFGWPDHLAPP-LERLCSIIKSIDSWLKtDPQHVVVVHCKGGKGRTGVVISAYMHF----SKMCSSPEAALDWFAIKRfy
..|     . . |  ...    ||||| .|| .. | .... ....|. ||...|.|||..|.||||..| ||. .     ... ..| |....  .|  
rtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqR..

ddkLGGVTQPSQRRYVHYFSDY
    |.|. |.| |.....  .
...pgavqtpeqyrflydalle
subfamily_VSP_pd Subfamily VSP 8-176 2.9e-54 178.2 In-house 25-197 (212) alignment 
Range on Protein: 8-176
Range on HMM: 25-197/212.0
VRHVDHEFDLDLTYITERIIAMSFPGTGLESTYRNNLRDVAKMLQRKHQDKYMVFNL-SERRYDISKLNHQVLDFGWPDHLAPPLERLCSIIKSIDSWLK
 |.    |||||||.|||||||||| .| .| ||| ...||..|..||.|.| |.|| ||| || . .|..|      ||  | ||.| .. | .  ||.
rrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvftkevkewle

TDPQHVVVVHCKGGKGRTGVVISAYMHFSKMCSSPEAALDWFAIKRF---YDDKLGGVTQPSQRRYVHYFSDY
 |...|...|||||||||| .. |..  |..... . .||.|. .|      .|  ||  |||.|||.|. . 
kdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqv
PTEN_1 8-179 2.1e-51 169.5 In-house 11-194 (196) alignment 
Range on Protein: 8-179
Range on HMM: 11-194/196.0
VRHVDHEFDLDLTYITERIIAMS-FPGTG-----LESTYRNNLRDVAKMLQRKHQDK-YMVFNLSERR------YD---ISKLNHQVLDFGWPDHLAPPL
 .. .....|||||||.|||||. .|...      |..||..|.|||..|.....|. ..|.||||..      ||     | . ..|.|...|| ||.|
knlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapsl

ERLCSIIKSIDSWLKTDP-QHVVVVHCKGGKGRTGVVISAYMHFSKMcSSPEAALDWFAIKRFYDDKLggvtQPSQRRYVHYFSDYLEG
..|. |.||...||. || ..||.||||.|.||.|.|. ||. ...  .... ||.....||    .     .|||.|...||.. |..
selfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn....spsqerlleyfaellae
0046846 (Phosphotyrosine protein) phosphatases II 10-177 2.4e-36 120.5 In-house 3-172 (176) alignment 
Range on Protein: 10-177
Range on HMM: 3-172/176.0
HVDHEFDLDLTYITERIIAMSFPGTGLESTYRNNLRDVAKMLQRkhqDKYMVFNLSERR-----------YDISKLNHQVLDFGWPDHLAPPLERLCSII
.. . .||||.||....|..|.|... ....|.   ... ...    . ..|.|| |..            .. ||..|.| ..|||| .|.|| |....
lrllgldldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllell

KSIDSWLKTDpqHVVVVHCKGGKGRTGVVISAYMHFSKMCSSPEAALDWFAIKRFYddklGGVTQPSQRRYVHYFSDYL
. |...|| .  ..|.|||..|.||||... ||.  .... |.| ||...  .|..    | |. |.|.|....|  .|
efirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl....gavqtpeQyrflyefelll
0039614 (Phosphotyrosine protein) phosphatases II 12-174 1.3e-32 108.8 In-house 78-285 (297) alignment 
Range on Protein: 12-174
Range on HMM: 78-285/297.0
DHEFDLDLTYI-----------TERIIAMSFPGTG-----LESTYRNNLRDVA----------------------------KMLQRKHQDKYMVFNLSER
  ..|||..||           | ..||...| ..     ..  .... . .                             ..|. .| | |.|..|. .
edgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevt

RYDISKLNHQVLDFGWPDHLAPP-LERLCSIIKSIDSWLKTD-PQHVVVVHCKGGKGRTGVVISAYMHF----SKMCSSPEAALDWFAIKRfyddkLGGV
... |.  .... .||||| .|| || |..... ....|... ....|.|||..|.||||..| ||. .    .. . ... |....  .|      |.|
nngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR.....pgav

TQPSQRRYVHYFS
. ||| |..... 
qtpsqyrflydal
0041856 (Phosphotyrosine protein) phosphatases II 13-174 5.3e-35 116.0 In-house 13-167 (182) alignment 
Range on Protein: 13-174
Range on HMM: 13-167/182.0
HEFDLDLTYITERIIAMSFPGTGLESTYRNNLRDVAKMLQRKHQDKY-MVFNLSERRYDISKLNH---QVLDFGWPDHLAPPLERLCSIIKSIDSwlktd
 ....||.||.......|.|.|  . |... |..||..|.  .. .. .. ||.|..|. ..|..   |.|...|||| .|.|. |...|. . .     
ydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfieevle.....

PQHVVVVHCKGGKGRTGVVISAYMHFSKmCSSPEAALDWFAIKRfyddkLGGVTQPSQRRYVHYFS
....|.|||..|.||||... ||.. ..   |.| |....  .|      |.|..|.| ...... 
eggpvlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrR.....pgmvitpnqyfflqlal
0043147 (Phosphotyrosine protein) phosphatases II 13-177 3.2e-33 110.3 In-house 9-160 (172) alignment 
Range on Protein: 13-177
Range on HMM: 9-160/172.0
HEFDLDLTYITERIIAMSFPgtglestYRNNLRDVAKMLQRKHQDKymVFNLSER---RYDISKLNHQVLDFGWPDHLAPPLERLCSIIKSIDSWLKTDP
. ..|||.||. |.||. .|       .||.| |. .||.... .   ..|| |.   ... ..|. |.| ..|||| .|.|| | .... ||..|  .|
nasyldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalsp

QHVVVVHCKGGKGRTGVVISAYMHFskMCSSPEAALDWFAIKRfyddkLGGVTQPSQRRYVHYFSDYL
...|.|||..|.||||... ||.    .. |.| |....  ||      |.|. |||.|...||...|
ggpvlVHCsaGvgRtgtlvaaylml..lglsleeavalvrekR.....pgavqnpsqyrflyyfekll
0044763 (Phosphotyrosine protein) phosphatases II 14-177 4.1e-23 77.4 In-house 18-170 (178) alignment 
Range on Protein: 14-177
Range on HMM: 18-170/178.0
EFDLDLTYITERIIAMSFPGtglestyrnnlRDVAKMLQRKHQDkyMVFNLSE---------RRYDISKLNHQVLDFGWPDHLAPP-LERLCSIIKSIDS
 . .....|.......|.|             |  ..|.. . .  .. ||.|          .|. .. . |.| ...||| .|. || .  ... |..
sdyinaseilpglylgslpp...........addlellkelgit..hivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefiee

WLKtDPQHVVVVHCKGGKGRTGVVISAYMHFSKMCsSPEAALDWFAIKRfyddkLgGVTQPSQRRYVHYFSDYL
.|. .....|.|||. |.||.|... ||.  .  . |.|.|....  .|       .|. |.|.|....|  .|
ald.ekggpvlVHCsaGvgRsgtlvaaylmkklgl.sleeaielvrerR.....p.ivpnpgqlrqLyefelrl
0036282 (Phosphotyrosine protein) phosphatases II 15-181 2.1e-45 149.9 In-house 8-173 (174) alignment 
Range on Protein: 15-181
Range on HMM: 8-173/174.0
FDLDLTYITERIIAMSFPGTGLESTYRNNLRDVAKMLQRKHQDKYMVFNLS-ERRYDISKLNHQVLDFGWPDHLAPPLERLCSIIKSIDSWLKTDPQHVV
..|||.|||.|.||...| . .|  .......|  .|. |. ..|...|.  |.|.| ..|..|.|...|||| .|.|. |....| ....|. ||...|
spldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpv

VVHCKGGKGRTGVVISAYMHFSKMCSSPEAALDWFAIKRFYddKLGGVTQPSQRRYVHYFSDYLEGKI
.|||..|.||||... ||..   ...|.. |||... .|..  . |.|. |||.|...||...|.|..
lVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlq..rpgmvqtpsQyrflyyfekllsgsl
0037934 (Phosphotyrosine protein) phosphatases II 15-173 7.7e-33 109.4 In-house 35-237 (243) alignment 
Range on Protein: 15-173
Range on HMM: 35-237/243.0
FDLDLTYITERIIAMSFPGTGLEST---------YRNNLRDVA----------------------------KMLQRKHQDKYMVFNLSERR---YDISKL
....|.|.|.|.||...| ..             .... . .                             ..|. .| |.|.|..|. ..   .| ..|
inanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrl

NHQVLDFGWPDHLAPP-LERLCSIIKSIDSWLKT-------DPQHVVVVHCKGGKGRTGVVISAYMHFSKMCSSPEAALDWFAIKRFYddklGGVTQPSQ
..... ..|||| .|.  | | .... . ....        |....|.|||..|.||||..| ||.. .... ..| |....  .|..     .|. |||
vihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpg....kavqtpsq

RRYVHYF
.|.....
yrflyea
0045450 (Phosphotyrosine protein) phosphatases II 15-173 3.9e-24 81.4 In-house 103-299 (307) alignment 
Range on Protein: 15-173
Range on HMM: 103-299/307.0
FDLDLTYI----------------------------------TERIIAMSFPGTGLESTYRNnlrDVAKMLQRKHQDKYMVFNLSERRYDISKLNHQVLD
.||....|                                  . ...|. .| .| | ||.|   .. ..|  .|.|.| |..|   ..| ..  ..|  
ydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygn...ftvtllseehldgytvrtlevtdldgtgesrtvth

FGW---PDHLAPP-LERLCSIIKSIDSWLKTD-PQHVVVVHCKGGKGRTGVVISAYMHFSKMC-------SSPEAALDWFAIKRfyddkLGGVTQPSQRR
| .   ||| .|| .| |...|. ....|... ....|.|||..|.||||..| ||.  . .         ... |....  .|      |.|. |.| |
fhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR.....pgavqnpeqyr

YVHYF
.....
flyea
0046845 (Phosphotyrosine protein) phosphatases II 15-173 5.6e-24 80.4 In-house 68-269 (284) alignment 
Range on Protein: 15-173
Range on HMM: 68-269/284.0
FDLDLTYITERIIAMSFPGTG-----------------------------LESTYRNNLRDVAKM-------LQRKHQDKYMVFNLSERR---YDISKLN
.|||||||. ..||...|  .                               . |...  .| ..       | ....| |.|..|. ..    . |.  
ydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtv

HQVLDFGWPDHLAPP-LERLCSIIKSIDSWLKT-DPQHVVVVHCKGGKGRTGVVISAYMHFSKM-------CSSPEAALDWFAIKRfyddkLGGVTQPSQ
..   ..|||| .|| .| | .... ....|.  ......||||..|.||||..| ... .. .       . ... |. ..  .|      | |....|
thfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqR.....pgmvqtleq

RRYVHYF
 |.|...
yrfvyea
0040439 (Phosphotyrosine protein) phosphatases II 15-173 7.5e-24 80.1 In-house 37-241 (249) alignment 
Range on Protein: 15-173
Range on HMM: 37-241/249.0
FD--------LDLTYITERIIAMSFPGTGLESTYRNNLRD-----------------------------------VAKMLQRKHQDKYMVFNLSERR-YD
|.        .|..||. |.||...| ..  . ... |..                                   . ..|. .. |.|.|..|   . ||
flsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlyd

ISKLNHQVLDF-GWPDHLAP-PLERLCSIIKSIDSWLKTD-PQHVVVVHCKGGKGRTGVVISAYMHF----SKMCSSPEAALDWFAIKRfyddkLGGVTQ
 ...  ... . .|||| .|  .| |...|. ....|... ....|.|||..|.||||..| ||. .     . . ..| |....  .|      |.|. 
gesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqR.....pgavqn

PSQRRYVHYF
|.| |.....
peqyrflyea
0045098 (Phosphotyrosine protein) phosphatases II 15-175 2e-23 78.7 In-house 5-269 (278) alignment 
Range on Protein: 15-175
Range on HMM: 5-269/278.0
FDLDLTYITERIIAMSFPGTGLESTYRNNLR---------------------------------------------------------------------
..|||....|.......|.. ... |..||                                                                      
asldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgre

----------------------DVAKMlQRKHQDKYMVFNLSERRYDISKLNHQVLDF-GWPDHLAPPLE---RLCSIIKSIDSWLK------------T
                      ..  . .  .  ...| ||. .|.|. ... ..|.. .|||| .|.|.    . .... |...||             
kcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllll

DPQHVVVVHCKGGKGRTGVVISAYMHFSKM--CSSPEAALDWFAIKRfyddkLG-GVTQPSQRRYVHYFSD
|....|.|||. |.||||... ||.  . .    ... |....  .|      |  |. ..| |....|  
dsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqR.....pglavqnleqyrflyefll
subfamily_Auxilin_pd Subfamily Auxilin 16-177 3.8e-54 175.9 In-house 8-164 (166) alignment 
Range on Protein: 16-177
Range on HMM: 8-164/166.0
DLDLTYITERIIAMSFPGTGLESTYRNNLRDVAKMLQRKHQDKYMVFNLSERRYDISKLNHQVLDFGWPDHLAPPLERLCSIIKSIDSWLKTDPQHVVVV
|||..||| ||| ||||  |.||||.||. ||...|. .|..||.|.|||.| |. .||. .|.. ||| . ||.|| | .. . ..|||| ||..||||
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvvv

HCKGGKGRTGVVISAYMHFSKMCSSPEAALDWFAIKRFYDDklggvTQPSQRRYVHYFSDYL
||| |.  ..|..||.. | .. |.||.|.. |..||   .      .||..||..|..| |
hckDGraasavlvsallvfcrllsepesavrlfsvkrlpig.....lspsekryleyladll
0051082 (Phosphotyrosine protein) phosphatases II 17-173 1.5e-24 81.8 In-house 6-147 (151) alignment 
Range on Protein: 17-173
Range on HMM: 6-147/151.0
LDLTYITERIIAMSFPgtgLEstyrnnlrDVAKMLqrKHQDKYMVFNLSERR---YDISKLNH---QVLDFGWPDHLAPPLERLCSIIKSIDSWLKTDPQ
....|.|........|   |.        |. ..|  |... ....|| .     |. . |.    .||.. ..|. .|.|. .  ..... ..|  ...
infsyvtgglyrsggp...la........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

HVVVVHCKGGKGRTGVVISAYMHFskMCSSPEAALDWFAIKRFyddklgGVTQPSQRRYVHYF
..|.|||..||||||... .|..   .  |.|.||... .||.      ||.||.| .....|
gpvlvHCsaGkgRTGtlvalylml..lgvsleealeeyrlkrp......gvvqpnqqflfqlf
subfamily_CDC14_pd Subfamily CDC14 18-151 3e-07 24.6 In-house 171-303 (328) alignment 
Range on Protein: 18-151
Range on HMM: 171-303/328.0
DLTYI-TERIIAMSFPGTGLESTYRNNLRDVAKMLQR-KHQDKYMVFNLSERRYDISKLNHQV---LDFGWPDHLAPPLERLCSIIKSIDSWlktdpQHV
|...|  ....|.. | .  . . . .|.  .|.|.  ....   |  | .. || .| ...     |  . |   |. . . . .. ...      .  
DfnwivPdkflalagPhnkskledgyplhaPeklleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGa

VVVHCKGGKGRTGVVISAYMHFSKMCSSPEAaLDWFAIK
..|||| | |||| .|..|.      ...|| . |. | 
iavhCkaGLGrtGtLiacylmkhyrftaaea.iawlric
0038934 (Phosphotyrosine protein) phosphatases II 21-172 2.1e-35 117.5 In-house 15-191 (194) alignment 
Range on Protein: 21-172
Range on HMM: 15-191/194.0
YITERIIAMSFPGTG-----LESTYRNNLRDVAKMLQRKHQDKYMVFNLS--ERRYDISKLNH---QVLDFGWPDH-LAPPLERLCSIIKSIDSWLKTDP
.||.|.||...| .|     .|..||....|. ..|. .... ..| .|.  || || ...     ..|.. .||.  .|.|| |..... .| .|. ||
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

QHVVVVHCKGGKGRTGVVISAYMHFSkMCSSPEAALDWFAIKR---------------FYDDKLGGVTQPSQRRYVHY
..||.||||.|.||||... ||.  . .. |.|.|...|..||               .|..   .|..|........
ggvvaVHCkaGlgRtGtlvaaYLiyr.lgmsaeeAialfrekRpgaipnqdyleallkrykelrkavlapekpellle
0049260 (Phosphotyrosine protein) phosphatases II 27-177 7.7e-28 92.5 In-house 5-149 (152) alignment 
Range on Protein: 27-177
Range on HMM: 5-149/152.0
IAMSFPGTGLESTYRNNLRDVAKMLQRKHQDKYMVFN-LSERRYDISKLNHQVLDFGWPDHLAPPLERLCSIIKSIDSWLKTDPQHVVVVHCKGGKGRTG
.||.|. .. . ...|.| |. .||.. . . . . . |.|. ..  .   |.| . |||| .|.|. |  ..  .. .|. |....|.|||..|.||||
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtg

VVISAYMHFskMCSSPEAALDWFAIKRfyddkLGGVTQPSQRRYVHYFSDYL
... ||.    .  |.| |....  ||      |.|. |.|.|....|...|
tlvaaylml..lgvsleeavalvrekR.....pgavpnpgqlrflyefekll
0048076 (Phosphotyrosine protein) phosphatases II 31-176 6.2e-27 89.4 In-house 3-141 (145) alignment 
Range on Protein: 31-176
Range on HMM: 3-141/145.0
FPGTGLESTYRNNLRDVAKMLQRKHQDKYMVFNLSERRYDISKLNHQVLDFGWPDHLAPPL-ERLCSIIKSIDSWLKTDpqHVVVVHCKGGKGRTGVVIS
.|   |.. |...| .. .. . |. . ..|.||.  ... ..|. |.| ..|||| .|.| | |..... |...|| .  ..|.|||. |.||||... 
wpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlva

AYMHFSKMcSSPEAALDWFAIKRFYddklgGVTQPSQRRYVHYFSDY
||. ...   |.| ||...  .|..     .|. |.|.|....|  .
aylmlllg.vsleealelvrsqrpg.....avpnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 31-177 4e-26 86.9 In-house 3-144 (144) alignment 
Range on Protein: 31-177
Range on HMM: 3-144/144.0
FPGTGLESTYRNNLRDVAKMLQRKHQDKYMVFNLSERRYDISKLNH--QVLDFGWPDHLAPPL-ERLCSIIKSIDSWLKtdPQHVVVVHCKGGKGRTGVV
.|   |.. |...| .. .. . |... ..|.||.| ..  .  ..  |.| ..|||| .|.| | |..... |...|.  . ..|.|||..|.||||..
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtl

ISAYMHFsKMCSSPEAALDWFAIKRFyddklGGVTQPSQRRYVHYFSDYL
. ||. . |.  |.| ||...  .|.     |.|. |.|.|........|
vaaylmk.klglsleealalvrsrrp.....gavpnpgqlrfLleyekll
subfamily_DSP11_pd Subfamily DSP11 35-153 1e-06 22.7 In-house 34-158 (178) alignment 
Range on Protein: 35-153
Range on HMM: 34-158/178.0
GLESTYRNNLRDVAKMLQRKHQDKYMVFNLS--ERRYDISKLNHQVL---DFGWPDHLAPPLERLCSIIKSIDSWL--KTDPQHVVVVHCKGGKGRTGVV
..|.  |   .|. ..|| |...  .| .|.  .| |. ..|... .    .  | |  |  | . . .. ....|  . | .... |||  |  ||| .
kveeekrftpkdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyl

ISAYMhFSKMCSSPEAALDWFAIKRF
|  |.  ...  .|| |.. |   | 
iCryl.idvegyepedaieafeearG
subfamily_CDKN3_pd Subfamily CDKN3 43-148 3.5e-06 20.7 In-house 70-170 (202) alignment 
Range on Protein: 43-148
Range on HMM: 70-170/202.0
NLRDVAKMLQRKHQDKYMVFNLSERrYDISKLnhQVLDFGWPDHLAPPLERLCSIIKSIDSWLKTDPQhvVVVHCKGGKGRTGVVISAYMHFSKMCSSPE
 ..||  .  |   .|| | .| .  |  . |   |  .  .| |.|     . |.. .   ||.  .   .||| || ||. .||.  . . .   .|.
gvedvfvlctrgelskyrvrrlldl.yqqagl..ivhhypiadglvpdiasclkileelrinlkayrk..tlvhcygglgrsslviaclllylddtiepk

AALDWF
 |.|  
daidkl
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 44-144 8.1e-06 17.1 Pfam-A 72-167 (168) alignment 
Range on Protein: 44-144
Range on HMM: 72-167/168.0
LRDVAKMLQRKHQDKYMVFNLSER--RYDISKLNHQVLDFGWPDhlappLERLCSIIKSIDSWLKTDPQhvVVVHCKGGKGRTGVVISAYMHFSKMCSSP
..||  .  |    || | || .   .| |    | . | | ||     .   . |.. . . ||   .   ..|| || ||. .| .. . .   . ||
iqdvfvfctrgelskyrvpnlldlyqqygivthhhpiadggtpd.....iascleimeelatclknyrk..tlihcygglgrsclvaaclllylsdsisp

EAA
| |
eqa
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 44-144 8.1e-06 17.1 In-house 72-167 (168) alignment 
Range on Protein: 44-144
Range on HMM: 72-167/168.0
LRDVAKMLQRKHQDKYMVFNLSER--RYDISKLNHQVLDFGWPDhlappLERLCSIIKSIDSWLKTDPQhvVVVHCKGGKGRTGVVISAYMHFSKMCSSP
..||  .  |    || | || .   .| |    | . | | ||     .   . |.. . . ||   .   ..|| || ||. .| .. . .   . ||
iqdvfvfctrgelskyrvpnlldlyqqygivthhhpiadggtpd.....iascleimeelatclknyrk..tlihcygglgrsclvaaclllylsdsisp

EAA
| |
eqa
subfamily_PTPN12_pd Subfamily PTPN12 46-137 3.4e-09 31.0 In-house 143-234 (290) alignment 
Range on Protein: 46-137
Range on HMM: 143-234/290.0
DVAKMLQRKHQDKYMVFNLSERRYDISKLNHQVLDFGWPDHLAPP-LERLCSIIKSIDSWLKtDPQHVVVVHCKGGKGRTGVVISAYMHFSKM
 | .. ... .| ...  |  .. . |.  .|     ||||  |   ..| ..|... .  . . .. .||||  | ||||..|.  .  . .
evtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrell
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 48-137 1.5e-08 29.1 In-house 148-240 (318) alignment 
Range on Protein: 48-137
Range on HMM: 148-240/318.0
AKMLQRKHQDKYMVFNLS--ERRYDISKLNHQVLDFGWPDHLAPPL-ERLCSIIKSIDSWLKTDPQHVVVVHCKGGKGRTGVVISAYMHFSKM
 .. .... ..|.. ...  ..  . |.  .|     |||.  |     | ......... ..  ....|||| .| ||||| |   .   ..
velkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdilleri
0047943 (Phosphotyrosine protein) phosphatases II 49-173 1.5e-19 66.0 In-house 140-267 (273) alignment 
Range on Protein: 49-173
Range on HMM: 140-267/273.0
KMLQRKHQDKYMVFNLSERR--YDISKLNHQVLDFGWPDHLAP-PLERLCSIIKSIDSWLKTD-PQHVVVVHCKGGKGRTGVVISAYMHF----SKMCSS
..|  .. | |.|..|  ..  .. |.  .... .||||| .|  || | ..|. ....|...  ...|||||..|.||||..| ... .     . . .
tllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd

PEAALDWFAIKRFYddklgGVTQPSQRRYVHYF
.. |. ..  .|..     .|. |.|.|.....
vleavkllrsqRpg.....mvqtpeqyrflyea
0051299 (Phosphotyrosine protein) phosphatases II 49-172 3.5e-18 61.5 In-house 152-280 (288) alignment 
Range on Protein: 49-172
Range on HMM: 152-280/288.0
KMLQRKHQDKYMVFNLSER------RYDISKLNHQVLDFGWPDHLAPP-LERLCSIIKSIDSWLKtDPQHVVVVHCKGGKGRTGVVISAYMHFSKMCSSp
..|  ...|.|.|..|  .        . |.  ..   ..|||| .|. .| | .... ....|. .....|||||. |.||||..| ... .. .    
tllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqleke.

eAALD-WFAIKRFYDDKLGGVTQPSQRRYVHY
   .|   |.||.   . | |. |.| |.|..
.ggvdvleavkrlreqRpgmvqtpeqyrfvye
subfamily_PTPRB_pd Subfamily PTPRB 49-137 6.5e-08 27.0 In-house 155-245 (293) alignment 
Range on Protein: 49-137
Range on HMM: 155-245/293.0
KMLQRKHQDKYMVFNLSERRYDISKLNHQVLDFGWPDHLAPP-LERLCSIIKSIDSWL-KTDPQHVVVVHCKGGKGRTGVVISAYMHFSKM
.... ........ .|. .. . ..  .|     ||||  |   . | .... ..... ||  .. .||||  | ||||. |.  . ....
tlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqai
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 49-139 1.7e-06 21.7 In-house 163-249 (302) alignment 
Range on Protein: 49-139
Range on HMM: 163-249/302.0
KMLQRKHQDKYMVFNLSERRYDISKLNHQVLDF-GWPDHLAPPLE-RLCSIIKSIDSWLKTdpqhvVVVHCKGGKGRTGVVISAyMHFSKMCS
..  .|.   | |    |.. .  |   ..| | .|||| ||        |.|  .|. |.     |.|||  | |||| ...   .  ..||
eftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvai.kyGiqlcs
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 50-138 3.9e-07 24.4 In-house 138-229 (274) alignment 
Range on Protein: 50-138
Range on HMM: 138-229/274.0
MLQRKHQDKYMVFNLSERRYDIS-KLNHqVLDFGWPDHLAPP-LERLCSIIKSIDSWLKTDPQH--VVVVHCKGGKGRTGVVISAYMHFSKMC
. . .....| | .|. .    . .. |  .   |||| .|   . | .... ...  ... ..   |||||  | ||||. |.. .   .. 
vekiverndysvrklvlkylerersvkh.ywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlr
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 50-148 2.5e-06 21.8 In-house 152-248 (288) alignment 
Range on Protein: 50-148
Range on HMM: 152-248/288.0
MLQRKHQDKYMVFNLSERRYDISKLNHQVLDFGWPDHLAPPL-ERLCSIIKSIDSWLKTDpQHVVVVHCKGGKGRTGVVISAYMHFSKMCSspEAALDWF
... |....... .|   .       .|    .||||  |   . |  ... ..   . | .  ..|||  | ||||. |.. .   .. .  |  .| .
lveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidavee..edyiDva
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 51-172 3.2e-08 28.0 In-house 153-277 (319) alignment 
Range on Protein: 51-172
Range on HMM: 153-277/319.0
LQRKHQDKYMVFNLS--ERRYDISklNHQVLDF---GWPDHLAPP-LERLCSIIKSIDSWLKTDPQHVVVVHCKGGKGRTGVVISAYMHFSKMcsSPEAA
........|.. .|.  ..  ..     .|  |    ||||  |  .  |  ..| |    .   .  .||||  | ||||  |   . . ..  . |..
eeeeeledyiirklklnkksseve..tRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlerv..keegv

LDWFAI-KRFYDDKLGGVTQPSQRRYVHY
|| | . .|    .   | .|.| .....
lDvfstvsrlRtqRnimvqrpeqYkfiye
subfamily_PTPN6_pd Subfamily PTPN6 51-129 3.9e-06 21.1 In-house 161-246 (306) alignment 
Range on Protein: 51-129
Range on HMM: 161-246/306.0
LQRKHQDKYMVFNLSERRYDISKLNHQVLDF---GWPDHLAPPLERL-CSIIKSIDSWLKTD---PQHVVVVHCKGGKGRTGVVIS
.. |....|.. .||  . . .| ...| ..    ||||  |       . .. ...  ..     .  .||||  | |||| .| 
vseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiv
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 53-171 8.5e-07 23.4 In-house 155-276 (305) alignment 
Range on Protein: 53-171
Range on HMM: 155-276/305.0
RKHQDKYMVFNLSERRYDISKLNHQVLDF---GWPDHLAPPL-ERLCSIIKSIDSWLKTDPQHVVVVHCKGGKGRTGVVISAYMHFSKMcsSPEAALDWF
.|.   |.  .|.    | .| ...||..    ||||  |     | |.|| .    | | .  ..|||  | ||||| |.  . . ..    |  .| |
ektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerl..kkEevvdvf

AI-KRFYDDKLGGVTQPSQRRYVH
 . |.    ... |..  |  ..|
evlkqlRskrmkmvqtldqYvflh
0049772 (Phosphotyrosine protein) phosphatases II 54-175 1e-21 73.4 In-house 167-277 (314) alignment 
Range on Protein: 54-175
Range on HMM: 167-277/314.0
KhqdkymvfnlSER--RYDISKLNHQVLDFGWPDHLAPPLERLCSIIKSIDSWlktDPQHVVVVHCKGGKGRTGV-VISAYMHFSKMCsSPEAALDWFAI
|          .|   . . ..|. ..|.. .||. ||.|| . .... |...   |....|.||||.||||||. |. ||.     . |.| ||...  
k..........eelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrl

KRFYDDKLGGVTQPSQRRYVHYFSD
||..  . | . |. |  ...... 
kRpinpnpgfieqleqyefileall
0050432 (Phosphotyrosine protein) phosphatases II 54-172 6.4e-15 50.7 In-house 176-293 (308) alignment 
Range on Protein: 54-172
Range on HMM: 176-293/308.0
KHQDKYMVFNLSERR--YDISKLNHQVLDFGWPDHLAPP-LERLCSIIKSIDSWLktdPQHVVVVHCKGGKGRTGVVISAYMHFSKMCSSpeAALDW-FA
...| |.|..|  .   .. |.  ..    .|||| .|| .| | .... ....|   |....||||. | ||||..| ... .. .       .|.  |
evlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqleke..ggvdvfea

IKRFYDDKLGGVTQPSQRRYVHY
.|..   . | |. |.| .....
vkklReqRpgmvqtpeqylflyr
subfamily_PRL_pd Subfamily PRL 54-130 3.7e-06 21.1 In-house 31-110 (151) alignment 
Range on Protein: 54-130
Range on HMM: 31-110/151.0
KHQDKYMVFNLSERRYDISKLN---HQVLDFGWPDHLAPPLERLCSIIKSIDSWLKTDPQHVVVVHCKGGKGRTGVVISA
|...   |    |  || .||.    .|||. . |  .|| | . . .. . .  | .|...| |||  | ||. |... 
kkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlval
Y_phosphatase Protein-tyrosine phosphatase 55-148 5.8e-09 31.1 Pfam-A 112-206 (235) alignment 
Range on Protein: 55-148
Range on HMM: 112-206/235.0
HQDKYMVFNLSER--RYDI-SKLNHQVLDFGWPDHLAPP-LERLCSIIKSIDSWLkTDPQHVVVVHCKGGKGRTGVVISAYMHFSKMCSSPEaaLDWF
....|.. .|. .    .  ..  .|.   .|||| .|   . | ..|... ..  .. .. |||||. | ||||..... . .... .  |  .| .
dekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee..vdvl
Y_phosphatase Protein-tyrosine phosphatase 55-148 5.8e-09 31.1 In-house 112-206 (235) alignment 
Range on Protein: 55-148
Range on HMM: 112-206/235.0
HQDKYMVFNLSER--RYDI-SKLNHQVLDFGWPDHLAPP-LERLCSIIKSIDSWLkTDPQHVVVVHCKGGKGRTGVVISAYMHFSKMCSSPEaaLDWF
....|.. .|. .    .  ..  .|.   .|||| .|   . | ..|... ..  .. .. |||||. | ||||..... . .... .  |  .| .
dekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee..vdvl
subfamily_PTPMT1_pd Subfamily PTPMT1 57-152 7.1e-10 33.6 In-house 55-148 (171) alignment 
Range on Protein: 57-152
Range on HMM: 55-148/171.0
DKYMVFNLSERRYDISKLNHQVLDFGWPDHL-APPLERLCSIIKSIDSWLKTdpQHVVVVHCKGGKGRTGVVISAYMHFSKMCSsPEAALDWFAIKR
. | .  |..   . .||. . | .  .|.  || ||.|   .. |..  ..  .. | ||||.|.||.. ....|.  .. .| || ||.  . ||
eeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvask..gkrvYvHCkaGrgRsatlvacylmkkekls.peeAlkalkkkR
0036941 (Phosphotyrosine protein) phosphatases II 58-175 5.8e-16 54.1 In-house 136-274 (297) alignment 
Range on Protein: 58-175
Range on HMM: 136-274/297.0
KYMVFNLSERR-----------------YDISKLNHQVLDFGWPDHLAPP-LERLCSIIKSIDSWLKTD-PQHVVVVHCKGGKGRTGVVISAYMHFSKMC
...|..||.                   .. |.  ..   .||||| .|.  . | ..|. ....||   ....|.|||..|.||.|..| |.. .. ..
dftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqle

S-------SPEAaldwfAIKRFYDDKLGGVTQPSQRRYVHYFSD
.       ..       |.| . . . | |....| |.....  
dklkeggvdile.....avkklReqRpgavqtleqyrflyeall
0051429 (Phosphotyrosine protein) phosphatases II 58-173 2.7e-12 42.4 In-house 102-220 (272) alignment 
Range on Protein: 58-173
Range on HMM: 102-220/272.0
KYMVFNLSER---RYDISKLNHQVLDFGWPDHLAPPlERLCSIIKSIDSwlktdpQHVVVVHCKGGKGRTGVVISAYMHFSKMCSS------------PE
 |.. .|  .    .. .   .. .  .|||| .|. | |..... . .      .. |.|||..||.|||.|. ....   .. .            .|
dyilrellltlllsagearevmhlhytdwpdhgvpq.eallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

AALDWFAIKRfyddkLGGVTQPSQRRYVHYF
.|...   .|      | |  . |..... .
eaveelraqr.....pgavqteeqylflyea
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 60-148 3.3e-07 25.1 In-house 133-224 (284) alignment 
Range on Protein: 60-148
Range on HMM: 133-224/284.0
MV--FNLSE--RRYDISKLNhQVLDFGWPDHLAPP--LERLCSIIKSIDSWLKTDPQHVVVVHCKGGKGRTGVVISAYMHFSKMCSspEAALDWF
.|  ..|||  .  || |.. |    ||||.  |    . .. . |      | . .. .||||  | ||||| |   . ...|    |  .| .
vvrdielsedgkekdirkir.qfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmke..ekqvdvy
subfamily_PTPRK_pd Subfamily PTPRK 61-171 4.7e-08 27.2 In-house 159-270 (314) alignment 
Range on Protein: 61-171
Range on HMM: 159-270/314.0
VFNLSE--RRYDISKLNHQVLDFGWPDHLAPPLER-LCSIIKSIDSWLKTdPQHVVVVHCKGGKGRTGVVISAYMhFSKMCSSpEAALD-WFAIKRFYDD
.|....  | ..  .. .|.   |||||  |  .. | .... .... .   .  .||||  | ||||. |   .    |    |  .| ..|.| . . 
ifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidi.vldmier.egvvdvfnavktlrsr

KLGGVTQPSQRRYVH
|   |    | ....
kvnmveteeqykfiy
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 62-139 3e-07 25.0 In-house 173-253 (319) alignment 
Range on Protein: 62-139
Range on HMM: 173-253/319.0
FNLSE--RRYDISKLNhQVLDFGWPDHLAPP--LERLCSIIKSIDSWLKTDPQHVVVVHCKGGKGRTGVVISAYMHFSKMCS
..|||  .  || |.. |    ||||.  |    . .. . |      | . .. .||||  | ||||| |   . ...|  
ielsedgkekdirkit.qfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmke
subfamily_PTPN3_pd Subfamily PTPN3 62-136 1.4e-06 22.4 In-house 160-234 (280) alignment 
Range on Protein: 62-136
Range on HMM: 160-234/280.0
FNLSERRYDISKLNHQVLDFGWPDHLAPPL-ERLCSIIKSIDSWLKTdPQHVVVVHCKGGKGRTGVVISAYMHFSK
. |.... . ..  .|.    ||||  |   . . ...... .  ..  .. ||||| .| |||||.|   . ...
lvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg.keePvvvhCsaGigrtGvlilletalal
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 66-132 1.3e-07 25.8 In-house 166-232 (315) alignment 
Range on Protein: 66-132
Range on HMM: 166-232/315.0
ERRYDISKLNHQVLDFGWPDHLAPP-LERLCSIIKSIDSWlKTDPQHVVVVHCKGGKGRTGVVISAYM
 |. . |.   |    .|||. ..  .  |  .|| . .  .   .. ..|||  | ||||||||.  
trkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvviside
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 66-132 8.7e-06 20.0 In-house 167-230 (281) alignment 
Range on Protein: 66-132
Range on HMM: 167-230/281.0
ERRYDISKLNHQvldfGWPDHLAPPL-ERLCSIIKSIDSWLKTDPQHVVVVHCKGGKGRTGVVISAYM
    ....|...     |||| .|   . | .  | . .  ... .. .|.||  | ||||. |.   
getreveqlayt....aWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDr
DSPc Dual specificity phosphatase, catalytic domain 69-143 7.9e-07 24.0 Pfam-A 38-106 (133) alignment 
Range on Protein: 69-143
Range on HMM: 38-106/133.0
YDISKLNHQVLDfgwpDHLAPPLERLCSIIKSIDSWlkTDPQHVVVVHCKGGKGRTGVVISAYMHFSKMCSSPEA
 .| .|. .| |    .. .   . | .... |..   .. .. |.|||. |  |.. .| ||.  .| .|. ||
seieylripved....etetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknlslneA
DSPc Dual specificity phosphatase, catalytic domain 69-143 7.9e-07 24.0 In-house 38-106 (133) alignment 
Range on Protein: 69-143
Range on HMM: 38-106/133.0
YDISKLNHQVLDfgwpDHLAPPLERLCSIIKSIDSWlkTDPQHVVVVHCKGGKGRTGVVISAYMHFSKMCSSPEA
 .| .|. .| |    .. .   . | .... |..   .. .. |.|||. |  |.. .| ||.  .| .|. ||
seieylripved....etetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknlslneA
PTPc_motif_SM00404 70-144 7.8e-06 20.8 In-house 46-114 (140) alignment 
Range on Protein: 70-144
Range on HMM: 46-114/140.0
DISKLNHQvLDFGWPDHLAPPLERLCSIIKSIdswlkTDPQHVVVVHCKGGKGRTGVVISAYMHFSKMCSSPEAA
..  |. . ||    |.|.. |... ..|...     .. .. |.|||. |  |.. .| ||.  .. .|  || 
gfqilqip.lddnekdklskyldkvldfiena.....ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeay
DSPc_SM00195 71-169 9.7e-09 30.3 In-house 156-253 (263) alignment 
Range on Protein: 71-169
Range on HMM: 156-253/263.0
ISKLNHQVLDFGWPDHLAP-PLERLCSIIKSIDSWLKTDpQHVVVVHCKGGKGRTGVVISAYMHFSKMCSSPEAALDWFaIKRFYDDKLGGVTQPSQRRY
 ..  .|.   .|||| .|   . . ......... .|  .. .||||. | ||||..... .  ||...  .  ...  .|.. . . | |..  | ..
etrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifei.vkelRkqRpgmvqtleqYlf
PTPc_SM00194 71-169 9.7e-09 30.3 In-house 156-253 (263) alignment 
Range on Protein: 71-169
Range on HMM: 156-253/263.0
ISKLNHQVLDFGWPDHLAP-PLERLCSIIKSIDSWLKTDpQHVVVVHCKGGKGRTGVVISAYMHFSKMCSSPEAALDWFaIKRFYDDKLGGVTQPSQRRY
 ..  .|.   .|||| .|   . . ......... .|  .. .||||. | ||||..... .  ||...  .  ...  .|.. . . | |..  | ..
etrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifei.vkelRkqRpgmvqtleqYlf
subfamily_PTPN13_pd Subfamily PTPN13 71-133 3.7e-06 21.4 In-house 162-225 (273) alignment 
Range on Protein: 71-133
Range on HMM: 162-225/273.0
ISKLNH-QVLDF-GWPDHLAPPL-ERLCSIIKSIDSwLKTdPQHVVVVHCKGGKGRTGVVISAYMH
 .. .. . |.|  ||||  |   . |  ... . . |.|  .  .||||  | ||.|..|. .. 
sgesrevahlnfvkwPdhgvPssaaellqfvaevrr.lqt.dagPivvhcsaGiGrsGtlitidvv
subfamily_PTPDC1_pd Subfamily PTPDC1 75-177 1.4e-13 45.7 In-house 82-175 (182) alignment 
Range on Protein: 75-177
Range on HMM: 82-175/182.0
NHQVLDFGWPDHLAPPLERLCSIIKSIDSWLKTDpqhVVVVHCKGGKGRTGVVISAYMHFSKMCSSPEAaldwfaIKRFYDDKLGGVTQPSQRRYVHYFS
.  |  |||.|. ...|||.  |.| ... |. .    | |||  |.|||||.|..|. ..|  .. .|      ||   . .   .   .| . |. |.
giyvynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyakrltaeka......iklvrskrpksiqtreqvelvkefa

DYL
 .|
lfl
subfamily_Ptp69D_pd Subfamily Ptp69D 75-132 9.3e-06 20.0 In-house 181-241 (307) alignment 
Range on Protein: 75-132
Range on HMM: 181-241/307.0
NHQVLDF---GWPDHLAPPLER-LCSIIKSIDSWLKTDpQHVVVVHCKGGKGRTGVVISAYM
...|. .   ||.|  .|   | |  .|. . .  |.. .  .||||. | ||.|....  .
srkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvalds
PTPc_DSPc_SM00012 76-195 8e-15 50.3 In-house 3-104 (105) alignment 
Range on Protein: 76-195
Range on HMM: 3-104/105.0
HQVLDFGWPDHLAPP-LERLCSIIKSIDSWLKTDP-QHVVVVHCKGGKGRTGVVISAYMHFSKMCSSPeaaldwfaikrfyddklggvTQPSQRRYVHYF
...   ||||| .|   . ........... .    .. |||||. | ||||... .... ......                     ..... ..|...
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket....................kevdifqivkel

SDYLEGKIKLSSEPMFLHHVIV
 .. .| ..   . .||.... 
rkqRpgmvqteeqylflyrall
0048567 (Phosphotyrosine protein) phosphatases II 78-152 1.1e-06 23.1 In-house 45-118 (157) alignment 
Range on Protein: 78-152
Range on HMM: 45-118/157.0
VLDFGwpdhlAPPLERLCSIIKSIDSWLK--TDPQHVVVVHCKGGK---GRTGVVISAYMhFSKMCSSPEAALDWFAIKR
  |||      ..| .| . |. ....||  .   ....|||| |    |||...|..|.   ..  .|| |.....| |
ffdfG.....PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYl.ilhlgftpeeaiaplrivr
subfamily_PTPRD_pd Subfamily PTPRD 80-148 2.3e-06 21.5 In-house 184-250 (564) alignment 
Range on Protein: 80-148
Range on HMM: 184-250/564.0
DFGWPDHLAPPL-ERLCSIIKSIDSWLkTDPQHVVVVHCKGGKGRTGVVISAYMHFSKMCSspEAALDWF
   |||| .|   . | ..|. . ..  .. .. .||||  | ||||. |   .   .. .  |. .| .
FtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerike..ektvDiy
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 81-131 5.9e-07 22.9 In-house 180-230 (515) alignment 
Range on Protein: 81-131
Range on HMM: 180-230/515.0
FGWPDHLAPPLE-RLCSIIKSIDSWLkTDPQHVVVVHCKGGKGRTGVVISAY
 .|||. .|.    |  .|| . .      .| ...||  | ||||||||. 
teWPdkGvpkhtssllklikevkadh.gqythpliihcsaGvGrtGvvisid
subfamily_RNGTT_pd Subfamily RNGTT 88-152 3.2e-09 30.7 In-house 91-154 (189) alignment 
Range on Protein: 88-152
Range on HMM: 91-154/189.0
APPLERLCSIIKSIDSWLKTDPQHVVVVHCKGGKGRTGVVISAYMhFSKMCSSPEAALDWFAIKR
||  |.  ..|| .... |  |..|. |||. |  ||| .| .|. . |.. | |||.. ||  |
aPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyL.vekedwsveaavalFakaR
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 185-308 1.3e-32 103.8 Pfam-A 3-133 (134) alignment 
Range on Protein: 185-308
Range on HMM: 3-133/134.0
SEPMFLHHVIVHGIPNFDSKGGCKPFLRVYDGLKLV---YTSGVFLVTQDMERVCITIEGGLILHGDVLIKCYHKNTLSSVRDIIFRCQFHTGAIK--DC
. ...|...|..|||||...|||||...||.| | |   ..|     ... . ...... .|.. ||||....||.. .. .. |||..|.|  |.  . 
pkrlelksiilegiPnfktrggckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsklpkkekifrvwFNTsFieknqn

VLVLDKTDLDEAHRD--KRFPDNCKVEFVFS
|| | | .||.|. |  |.|..|.|||.||.
vltlpkneLDkalkdkdkkfsknfkvelvfe
SH2 SH2 domain 321-413 8.1e-13 38.9 Pfam-A 1-74 (77) alignment 
Range on Protein: 321-413
Range on HMM: 1-74/77.0
WYKPKITRDQAINVLKD-KEPGLFVVRDSQSFPGAYGLAVKVAIppphvlqgdltkvdlaneKIRHFLIESTKKGvKLKGCDNEPvFGSLAAFV
||  ||.|..| . |.. |..| |.||.|.|.|| | |.|.                     |..|. |.|...| |.   .||  | ||.  |
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddg..................kvkhyriqsleng.kyyitenek.fsslqeLv
PTB Phosphotyrosine-binding domain 457-588 2.2e-20 61.8 Pfam-A 2-126 (131) alignment 
Range on Protein: 457-588
Range on HMM: 2-126/131.0
MKVMFVGESNVEMLSGSTAVQRTVEDLLKYKATPRFTPAS--FKVTREGVTITDLERKVFFrKHFPMTSILHCGIDPLDQRWDLhlpdytgksrTFGMVV
..| ..   ... | | .||..... |  ..| .. ....  .||  .|||.|| ||| .. ...|. |. .| ... ..|..            ...|.
yrVehLttvdldsltgveavedaiaklklldakgkvwaqevllkVsaqgvtLtDnerKeel.esyplnsvkkckavleerryes..........llalva

RRIGEAGNDCHLFA--EVDDDHSVNTVINLVNKYIS
|. ... .. |||.  |.. .   . . . ..|. .
repesskenvhlFqcdeleaeqiaediekalskvkl