Gene NvecPTP-sf2-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP044_AA protein Get Run
NvecP044_AA_0-235 phosphatase_domain Get Run
NvecP044_AA_247-526 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 1-314 7.8e-136 449.0 In-house 49-358 (564) alignment 
Range on Protein: 1-314
Range on HMM: 49-358/564.0
REKNRYANIIAYDHSRVILEPdSAGDKICDYINASYLHGFDgSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDV-SREYG
..|||||||.|||||||.|..   ||. .||||||...|.. . |||||||||.  .. |||||.|...|..|||||.|.|..|||||.|||.  . .||
kaKNRyanivaYdhsRVvLsk.vegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetyg

DITVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHREKK
..||.....| .|||. | ..| | .. ..| | | ||| |||.|||..||..| ...||.| |. ..|||||||||||||||..|.|||||.... ||.
eltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeekt

VDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEVPVQDLSRTITKLSAVVPGKGITGFADEFQRLRlVSDSIKEDETNVAKNLQNQNKNRDM
||||.||...|..| .||||||||||.| |||||  ||||||....|.....||. |......||.. |||||   .. |. .| .||.. .|..|||  
vDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeveedtemtgleleFqrLa.takeieleefavatkpknkkknrfs

EYLPCElnSSRVVLF
. |..|  |.|||| 
nilale..scrvvls
subfamily_PTPRA_pd Subfamily PTPRA 1-269 2.8e-91 300.8 In-house 59-330 (330) alignment 
Range on Protein: 1-269
Range on HMM: 59-330/330.0
REKNRYANIIAYDHSRVILEPdSAGDKICDYINASYLHGFDGSfKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDV-SREYG
.||||. ||. ||.||||| .   | .  ||||||...|.    . .||.|||   .  |||||||. ||| |||||.||| .. ||.|||||  .  ||
keknrvvnilPydfsrvilsv.keGveesdyinasfidGykek.dkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyG

DITVSVHSTEVFADYTKRVLFLA----KRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAH
.|.|.|. ..|  ||| | . .     .. | ..| | |.||| ||| ||| ..  .| . |||.. |.  .|||||||||||||||..|..||.|.. .
nirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervk

REKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEVPVQDLSRTITKLSAVVPGKGITGFADEF
 |.|||... |. .|  | .||||.||| |.. ..||  . |.||. |  | . . || . ..|   .|. .||
aerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynkitgtdkigleeef
subfamily_PTPRK_pd Subfamily PTPRK 1-270 1.2e-90 298.6 In-house 44-313 (314) alignment 
Range on Protein: 1-270
Range on HMM: 44-313/314.0
REKNRYANIIAYDHSRVILEPdSAGDKICDYINASYLHGFDGSfKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVSREYGD
|||||. .|.|||.|||.| .   ||   |||||... ..  . .|.|.||||.     ||||....|..| |||||.|.|  .||| .|||. .. |||
reknrsgdilaydrsrvflit.idgdpssdyinaalidsykrp.aafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygd

ITVSVHSTEVFADYTKRVLFLAK--RSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHREK
| | . .||. |.. .|.. . |  |.  ..| | |..|. ||| .||..||..|.. ..|.. .. . |.|||||||| ||||..|||| .|. ..||.
ikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmiereg

KVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEVPVQDLSRTITKLSAVVPGKGITGFADEFQ
 ||... |  .|  .. ||.|||||.|.. .|||| .||.| .|| ..  .  . . . |    . . .|||
vvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlkeefq
0050432 (Phosphotyrosine protein) phosphatases II 1-238 1.9e-90 298.6 In-house 69-303 (308) alignment 
Range on Protein: 1-238
Range on HMM: 69-303/308.0
REKNRYANIIAYDHSRVILepdsagDKICDYINASYLHGFD-GSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDV----S
..|||| .|..||||||.|      |. .||||||| .|.. .. ...||||||   .. |||||.|.... ||||||.| | ...||.||||.     |
kdkNrykdilpydhsRVkl......degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggs

REYGDITVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNpyGSGPIVVHCSAGVGRTGAYIAIDAMLNQAH
.|||..|| . |.||..|||.|.| | . .. . |.| ..|.| ||| |||......| | ..|.  .  ..|||||||||||||||..||.| .|.| .
leygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqle

REKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGN
.|..||....| ..|. | .||||.|||.|...|.||   .  
keggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
subfamily_PTPRG_pd Subfamily PTPRG 1-247 9e-89 293.2 In-house 48-300 (563) alignment 
Range on Protein: 1-247
Range on HMM: 48-300/563.0
REKNRYANIIAYDHSRVILEPDSAGDKICDYINASYLHGFDGSfKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWP-DVSREYG
..|||| ||.|||.||| |.| .  .|  |||||.|..|.  | ||.||||||.   | |||||||....|.|||.|||.|... ||..||| | | .||
krKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqks.kafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetyg

DITVSVHSTEVFADYTKRVLFLAK----RSE--ADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQ
 ..|   ..||.| ||.| | . .    . .   ....| | |.| |||.|||.|.. || | || .| |.   ||||||||||||||| ||..|..|.|
alqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkq

AHREKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEVPVQDLS
 ..|..|.... . ..|  | ..|||||||||.| |.|||   ..||.  ... 
iqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqve
subfamily_PTPRB_pd Subfamily PTPRB 1-234 2.6e-86 284.3 In-house 52-285 (293) alignment 
Range on Protein: 1-234
Range on HMM: 52-285/293.0
REKNRYANIIAYDHSRVILEPdSAGDKICDYINASYLHGFDgSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDV--SREY
|.|||| ||..|||||| |..  ....  |||||.|..|.  | . .||||||.  .. |||||.|..|| .|||||.| |  ||||..|||.   .  |
raknrytnilpydhsrvkLaa.lkdesgsDYinanyipgyn.sprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvly

GDITVSVHSTEVFADYTKRVLFLAKrsEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANN--PYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHR
|||.|.. ..|.  |.. | | . |  | ..|.| |.||| ||| |||......| | ..|. .      ..||||||||||||||..||.| .|.. ..
Gdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaiee

EKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEAT
|  |||.  |  .|..| ..||||.||||.| ..|.  
edyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_PTPN6_pd Subfamily PTPN6 1-231 2.1e-78 258.4 In-house 55-294 (306) alignment 
Range on Protein: 1-231
Range on HMM: 55-294/306.0
REKNRYANIIAYDHSRVILE-PDSAGDkicDYINASYLH-GFDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVS--R
.||||| ||. .||.||||. |. .|.   |||||.|..  . || |.|||||| . .   |||||.|||.| ||||.|.  |  | || .||||..  .
keknryknilPfDhtrvilkepsvpgs...dyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeeke

EYGDITVSVHSTEVFADYTKRVLFLA-KRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGS----GPIVVHCSAGVGRTGAYIAIDAML
|||.|.|.  | .  |||. | | .. |... ..|.|.|.||..|||.|||..  ||| | ..||... . .    ||||||||||.||||..| ||..|
eyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDill

NQAHRE---KKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAIL
.. ...    ..||.| |...|. |  .||||.|| ||..|| 
kliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
subfamily_CG7180_pd Subfamily CG7180 1-238 6.4e-59 194.0 In-house 43-294 (296) alignment 
Range on Protein: 1-238
Range on HMM: 43-294/296.0
REKNRYANIIAYDHSRVILEpDSAGDKICDYINASYLHGFDGSfKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKvKCHQYWPDV-SREYG
|||||. ... ||. ||.||    |..  |||||.|  .|    |.|| |..|.  .  .|||....|..  .|.||.  . .| ....|||     .||
reknrdvkvvPyDynRvvLe.kldGeeksdYinavyvdsflkk.keyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqyg

DITVSVHSTEVFADYTKRVLFLAKR----------SEADKRHVVQLHFTVWPD-KGVPQHATAVLGFRKKVNANN-----PYGSGPIVVHCSAGVGRTGA
.| | . ... .|. ..| . | |.           .|..| | ....|.|.  . ||  ..|.. .|..|.            ||.||..| |..|.|.
eifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGv

YIAIDAMLNQAHREKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGN
|.|||| |.....|..||....| ..||.| ..|.. |.| ..   .||| .|. 
ylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_PTPN1_pd Subfamily PTPN1 1-247 1.8e-58 192.6 In-house 33-284 (290) alignment 
Range on Protein: 1-247
Range on HMM: 33-284/290.0
REKNRYANIIAYDHSRVILEPDSAgdkicDYINASYLHgFDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVSR----
|..||| ..  |||||..|| ..      |||||| .. ..   . || ||||..     ||.|.|..||  .||| .. | |..||.||||   .    
rnlnryrdvspydhsrikleradn.....dyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekel

EYG--DITVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPY--GSGPIVVHCSAGVGRTGAYIAIDAMLN
..    ..| . |.|.   || |.| | ...  . |.... |.| ||| |||.  .| | |  ||          || |.|||||.||.|... .|..| 
lledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclv

QAHREKK---VDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEVPVQDLS
. .....   ||| | .  .|. |. ..|| .|  | ..|||| . . ...  ||.  
liekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvqkrw
0049772 (Phosphotyrosine protein) phosphatases II 1-233 4.3e-38 127.2 In-house 47-279 (314) alignment 
Range on Protein: 1-233
Range on HMM: 47-279/314.0
REKNRYANIIAYDhSRVILePDSAGDKiCDYINASYLHGFdgsfKAYIATQGPVVASFVDF----------WRMI--WQEKSAVIVM-------------
|.|||| .|. .| .|||| |   ..  .|||||||..||    ...||||||    .|||          |||.  .. .. .|||             
rdknryldilpad.nrvil.pglpvsg.sdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrL

--------LTNLKESEKVKCHQYWPDVSreygditvsvhstevfaD-------YtkrvlflakrseadKRHVVQLHFTVWPDKGVPqHATAVLGFRKKVN
        |..| .     . .....                   .       .              .|...... . .|| ..|     .. | . ..
daAlgKtpllildgngneptaadlellk.................eelydpelf..............erlgikylripvpDgsap.lledfdeflefie

ANnpYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAhrekKVDIYKYVEMMRRDRI-----HMVQTEEQYIFVHMAILEA
..     ||..|||.||.|||| ..... .. .     .|.. . .|..|. |      ..... |||.|...|.||.
ea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealley
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2-247 3.4e-126 414.6 In-house 11-249 (250) alignment 
Range on Protein: 2-247
Range on HMM: 11-249/250.0
EKNRYANIIAYDHSRVILEPDSaGDKICDYINASYLHGFDGSfKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVkCHQYWP-DVSREYGD
||||||.|||.|.|||.||... |||..||||||.|||.|.. ||.||||||..|...|||||...|||..||||||||||||. .||||| .....|||
eknryadiialdssrvvLekek.gdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyGd

ITVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPY-GSGPIVVHCSAGVGRTGAYIAIDAMLNQAHREKK
.|||..|.|.|||||||.|.|.|...||.|.|.||||.||||||||..|||||...|||.|.... |..|..|.|||||||.||.|||||.|.....||.
vtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekv

VDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCgntevpVQDLS
||..|.....|.||.|.|...|||.||...||.|...      |.|..
vdvfkvikvlrkdrphavesleqyvfvyeiilkalds......vedya
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2-241 7.3e-115 378.3 In-house 58-297 (298) alignment 
Range on Protein: 2-241
Range on HMM: 58-297/298.0
EKNRYANIIAYDHSRVILEPDSaGDKICDYINASYLHGFDGSFkAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPD-VSREYGD
.|||||.|||.|.|||.|| .. .|...||||||.||...|.  |.||||.|......|||||...|....|||||||.|..|.|.|.||||  ...||.
kkNRyadiialdssRvvLeked.adeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketyge

ITVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNAnNPYGSG--PIVVHCSAGVGRTGAYIAIDAMLNQAHREK
||||..|.|.|||...| |...|..|...|.|.|||||.|||||||..||.||....||.| ... .|  |..|.|||||||.|..||||..|.....|.
itvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeq

KVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEV
.||....|...|..|...|||||||.|...|.|||. ..|.|.
vvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2-272 4.2e-100 329.9 In-house 48-318 (318) alignment 
Range on Protein: 2-272
Range on HMM: 48-318/318.0
EKNRYANIIAYDHSRVILEPdSAGDKICDYINASYLHGFDgSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPD-VSREYGD
 |||||||.||||.|| |..  .|..  |||||.|. |.  . |||||.|.|.   . |||||.|. .||||||||...|. |.|.|.|||.  ||.||.
aknryanilaydhtrvkLqm.legeegsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygk

ITVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANN-PYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHREKK
..| ....  ..||. | . . .. | ..|.| | |.| |||.|||.... .| . ..|.. . . | ||||||||||||||| .||.|..|.... |. 
lvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaeal

VDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEVPVQDLSRTITKLSAVVPGKGITGFADEFQRL
||....|...|. |  |||||.||.|.. ..|||  .|.|||  .||.. | .|  . |  | | .  |||||
vDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpesgttemdaefqrl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2-233 1.8e-98 323.5 In-house 9-239 (239) alignment 
Range on Protein: 2-233
Range on HMM: 9-239/239.0
EKNRYANIIAYDHSRVILEPDSaGDKICDYINASYLHGFDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVSREYGDI
 |||||||..||||||.||  |  |   ||||||||. .||| |||||||| | .|  |||||.|||. .|||||| | |  | |||||||| . .| ..
aknryanivtydhsrvvlekls.ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnl

TVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHREKKVD
 |... |||||||  | . ...  ....|.| | ||||||||||||.||||||.|.|.  ..  |. | |.|||||||||||.. ||||| ||...| ||
rvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvd

IYKYVEMMRRDRIHMVQTEEQYIFVHMAILEA
|..||. .| || ||||| |||.|.|.|.|||
ifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2-232 7.1e-98 321.5 In-house 10-239 (239) alignment 
Range on Protein: 2-232
Range on HMM: 10-239/239.0
EKNRYANIIAYDHSRVILEPDSaGDKICDYINASYLHGFDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVSREYGDI
 |||||||..||||||.||  |  |   ||||||||. .||| |||||||| | .|  |||||.|||. .|||||| | |  | |||||||| . .| ..
aknryanivtydhsrvvlekls.ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnl

TVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHREKKVD
 |... |||||||  | . ...  ....|.| | ||||||||||||.||||||.|.|.  ..  |. | |.|||||||||||.. ||||| ||...| ||
rvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvd

IYKYVEMMRRDRIHMVQTEEQYIFVHMAILE
|..||. .| || ||||| |||.|.|.|.||
ifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2-270 4.8e-96 316.6 In-house 50-319 (319) alignment 
Range on Protein: 2-270
Range on HMM: 50-319/319.0
EKNRYANIIAYDHSRVILEPdSAGDKICDYINASYLHGFDGSfKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVS-REYGD
.|||| ||.|||..||.| .   | .  ||||||.. |..   ...||||.|.   . |||||.|.|.| ..||||.|.|  |||...|||.    ||| 
kknryqnilaydrtrvvlse.ldgvegsdyinasfidgyqer.ekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGr

ITVSVHSTEVFADYTKRVLFLAKR-SEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVN-ANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHREK
..| . . |  .|| .| |.| |. || . |.|.. ..| |||..||..||..| . |... . .   ||||||||||||||||..|..||||.. ..| 
livtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeeg

KVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEVPVQDLSRTITKLSAVVPGKGITGFADEFQ
 .|....| ..|  |  |||..|||.|.. |.|||  .|.||. ||||   . .|.  |.. | ||.. |||
vlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtgetglerefq
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2-232 6.8e-90 295.4 In-house 5-237 (237) alignment 
Range on Protein: 2-232
Range on HMM: 5-237/237.0
EKNRYANIIAYDHSRVILEPDSAGdkiCDYINASYLHGFDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVS--REYG
 ||||.||.|||||||.|.   .|   .|||||.||.||||. | |||.|||. .|  |||.|.|||| .|||||| | |....|||.|||.    . ||
iknrygnivaydhsrvvlkgagsg...sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

DITVSVHSTEVFADYTKRVLFLAKRSEA-DKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPY--GSGPIVVHCSAGVGRTGAYIAIDAMLNQAHR
 .|||..  | |.||| | | |.|| .  . | . | .||.|||.||||...|.| |||..  ..|.   ||| ..|||||||||| .. ||||| ||. 
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqake

EKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILE
.| ||||.||  .  || ...||..||.|.| .|||
kkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2-254 8.6e-89 292.7 In-house 48-303 (305) alignment 
Range on Protein: 2-254
Range on HMM: 48-303/305.0
EKNRYANIIAYDHSRVILEPDSAGDkICDYINASYLHGFDGSfKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVSRE---Y
.|||...|. .|..|.|| ...  |   |||||||..|.... |.||..|||.    .||||.|..||  .|||||.|.| .| ||.||||.  .|   .
aknrlkeitlldddriiltekesld.dsdyinasyvdgykrk.kkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkef

GDITVSVHSTEVFADYTKRVLFLAK-RSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSG-PIVVHCSAGVGRTGAYIAIDAMLNQAHR
|...| ..|.. ..||..| | ... ... ..| |.|...| |||.|||| ||..| . |.|. .   . | |..|||||||||||..||.| .|.....
gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkk

EKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEVPVQDLSRTITKLS
|. ||.....  .|. |. |||| .|| |.| |. | . ||.|.. ...|.  . || 
EevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnklk
0046845 (Phosphotyrosine protein) phosphatases II 2-241 2.5e-88 291.4 In-house 30-281 (284) alignment 
Range on Protein: 2-241
Range on HMM: 30-281/284.0
EKNRYANIIAYDHSRVILEPDSAGDKICDYINASYLHGFD----GSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDV--S
.|||| .|..||||||.| . . ... .|||||||..|.|     . |..||||||.  .. |||||.|.... ||||||.| | ...||.||||.   .
sknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegev

REYGDITVSVHSTEVFADYTKRVLFLAKRS-EADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNP--YGSGPIVVHCSAGVGRTGAYIAIDAMLN
 .|||.|| . |.||. |||.|.| | . . .   |.| ..|.| ||| |||.... .| | ..|.  ..  .|.|||||||||||||||..||.| .|.
ltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllle

QAHREK---KVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEV
| ..|.   .||....| ..|. | .||||.|||.||..|.||.  ...| .
qlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
0051299 (Phosphotyrosine protein) phosphatases II 2-233 2.6e-88 291.5 In-house 51-285 (288) alignment 
Range on Protein: 2-233
Range on HMM: 51-285/288.0
EKNRYANIIAYDHSRVILEPDSAgDKICDYINASYLHGFDGSFKaYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWP-DVSREYGD
||||| .|..||||||.| . .  .  .|||||||..|.. . | .||||||   .. |||||.|.... ||||||.| | ...||.|||| . | .|||
eknRysdilpydhsRVkLsvldg.vegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygd

ITVSVHSTEVFADYTKRVLFLAKR----SEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHR
|||   |.||..|||.|.| . .      .  .|.| ..|.| ||| |||......| | ..|.  .. |.||.||||||||||||..||.| .|.| ..
itvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlek

EKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEA
|..||....|...|. | .||||.|||.||..|.||.
eggvdvleavkrlreqRpgmvqtpeqyrfvyealley
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2-313 1.1e-86 286.0 In-house 45-353 (515) alignment 
Range on Protein: 2-313
Range on HMM: 45-353/515.0
EKNRYANIIAYDHSRVILEPDSAgDKICDYINASYLHGFDGSfKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPD---VSREY
.|||| ||. || .||.||     .   ||.||||...||   |||||.|||  ||  ||||...||. . |.|.|.|||..|.|| .||||    | ..
kknryknilPydsvrvklevind.nPhsdyfnasyipsfdnd.kayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkf

GDITVSVHSTEVFADYTKRVLFLAKRSEadKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHREK
| | |.. |.|  .. .|| | . | ..   | | | ||| |||||||.|....| . |.| |..   . |...|||||||||| .|.|| .. .|.  .
Gsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttr

KVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEVPVQDLSRTITKLSAVVPGKGITGFADEFQRLRLVSDSIKEDETNVAKNLQNQNKNRD
 ||....|. .|..| ..|||.||| |.. |.||     || .||  ..  .  | .   |.| . ...||| |. .       .|  ..  .|. ||| 
mvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlkslcpdppasqtrsgrtrdnhpknry

MEYLPCELNssRVVL
 . || . |  ||.|
gnnlplqrn..rvil
0040438 (Phosphotyrosine protein) phosphatases II 2-270 1.2e-86 286.2 In-house 45-312 (317) alignment 
Range on Protein: 2-270
Range on HMM: 45-312/317.0
EKNRYANIIAYDHSRVILEPDSAgDKICDYINASYLHGFDGSFKaYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWP-DVSREYGD
.|||| .|. ||||||.| |..  |  .||||||| .|.. . | .||||||   .. |||||.|.... ||||||.|.| ...||.|||| . . .|||
dknrypdilpydhsRVkLsplgg.dldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygd

ITVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHREKKV
.|| . |.|. |..| |.| . .  . ..|.| ..|.| ||| |||.. . .| | ..|..... ..||..|||||||||||..||.. ||.| ..|..|
ftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggv

DIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEVPVQDLSRTITKLSAVVPGKGITGFADEFQ
|... |...|. | ..|||.|||.|...|.||   ...| .|...| . . || ....... ..   |..
dveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvklkekelk
0036941 (Phosphotyrosine protein) phosphatases II 2-246 1.2e-85 282.7 In-house 41-289 (297) alignment 
Range on Protein: 2-246
Range on HMM: 41-289/297.0
EKNRYANIIAYDHSRVILepdsaGDKICDYINASYLHGFDGSFKaYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPD---VSREY
||||| .|..|||.||.|     .|  .|||||||. |.| ..| .||||||   .. |||||.|.... ||||||.| | ...||.||||.    | .|
eknRykdilpydhtRVkl.....ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegeslty

GDITVSVHSTEV--FADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPY--GSGPIVVHCSAGVGRTGAYIAIDAMLNQA
||.|| . |.||  ..||| |.| . .  . ..|.| ..|.| ||| |||.... .| | ..|.  ...  ..||..|||||||||.|..||.| ||.| 
gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqql

H---REKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEVPVQDL
.   .|..|||...| ..|. | ..|||.|||.|...|.||   ...| .|...|
edklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllkl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2-233 9.6e-85 279.1 In-house 43-275 (281) alignment 
Range on Protein: 2-233
Range on HMM: 43-275/281.0
EKNRYANIIAYDHSRVILEPDSAgDKICDYINASYLHGFDGSfKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVS--REYG
.|||| ||.|||..|| ..|... .| .|||||... |..|  |.|||||||| ||.|.||.|.|..|  .|||.|.  |..|.|||.|||| .   .||
lknrYsnivaYDatrvkvtpnee.nkntDYinanfvpgykge.keyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkyg

DITVSVHSTEVFADYTKRVLFLaKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKV-NANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHRE-
|.||. ...|  | | .|.. | .|.....|.|.||..| |||.|||. ....|.|||.| .....    |.|.||||||||||.|||.| .......| 
dvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveael

KKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEA
...|.   |. .|..|  ||||  || ||. |.|.|
eeldvkavvaelrkernlmvqtvvqyefvykavlda
0047943 (Phosphotyrosine protein) phosphatases II 2-232 7e-84 276.8 In-house 40-270 (273) alignment 
Range on Protein: 2-232
Range on HMM: 40-270/273.0
EKNRYANIIAYDHSRVILepdsaGDKICDYINASYLHGFDGSFKaYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDV----SRE
.|||| .|..||||||.|     ||. .|||||||. |.. . | .||||||   .. |||||.|.... ||||||.| | ...||.||||.     | .
dknrykdilpydhsrvkl.....gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelslt

YGDITVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPY--GSGPIVVHCSAGVGRTGAYIAIDAMLNQAH
||..|| . |.|...|||.|.| | . .  ..|.| ..|.| ||| |||.. . .| | ..|.  . .  ..||.||||||||||||..||.| .|.| .
ygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqle

REKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILE
.|..||....| ..|. | .||||.|||.|...|.||
keggvdvleavkllrsqRpgmvqtpeqyrflyealle
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2-266 1.1e-82 272.5 In-house 51-311 (315) alignment 
Range on Protein: 2-266
Range on HMM: 51-311/315.0
EKNRYANIIAYDHSRVILePDSAGDKICDYINASYLHGFDGSfKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVSREYGDI
.|||| ||||||.||| | |    |. .||.||... |..   . |||.||| |||  ||||....|. . ||||||| | || |. .||||    || |
qknryiniiaydksrvql.pllendphsdyvnanfidGynkk.rryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGki

TVSVHSTEVFADYTKRVLflAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHREKKVD
||.  | ||. .|| | |  .  .. . |.|||||.| ||| |||....... . ..|.  .    |.|||||||||||||..|..||.|.||. |. .|
tvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaid

IYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEVpVQDLS-RTITKLSAVVPGKGITGFA
.|.... .|. ||.|||. ||| |.. |.||. |||.| .  |||       | |  |  | | . 
vynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsi.aqdlylqrydsllapspdtgstllq
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2-272 6.4e-82 269.9 In-house 46-315 (315) alignment 
Range on Protein: 2-272
Range on HMM: 46-315/315.0
EKNRYANIIAYDHSRVILEP-DSAGDKicDYINASYLHGFDGSfKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPD---VSRE
.|||| ||. .|..||.||  |   |.  |||||||....|   |||||.|||  ||  |||||..||| . |||.|...|..|.|| |||||    | |
kknryknilPldsarvkleviddsPds..dyinasyiksvddd.kayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsve

YGDITVSVHSTEVFADYTKRVLflAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHRE
.| | |.. |.|  .| ..| |    |   ..| | | .|| ||||||.......| . |.| |.|     ...|||||||||||  |.|| ...|..|.
fGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrt

KKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEVPVQDLSRTITKLSAVVPGKGITGFADEFQRL
. ||....|...|..|...|||||.| |.. |.||     || ..|  ..  .  | . | |.| . ...||..|
rsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvdgsgrskmtkefetl
Y_phosphatase Protein-tyrosine phosphatase 2-232 9.2e-82 269.3 Pfam-A 3-235 (235) alignment 
Range on Protein: 2-232
Range on HMM: 3-235/235.0
EKNRYANIIAYDHSRVILepdSAGDKICDYINASYLHGFDgSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWP---DVSREY
.|||| .|..||..|| |   .  .. .|||||.|..|.. . |..||||||.  .. |||||.||||. ||||||.|.|....||.||||   . | .|
kknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDITVSVH-STE-VFADYTKRVLFLAKRSEAD-KRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAH
|||.| .  ...   ..|| |.| | |. | . ||.| |||.| |||.|||......| . .||. ..   |||.|||||||||||| ..|.|..|.|..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

REKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILE
.|..||....|...|. |..|||..|||||...||||
aeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 2-232 9.2e-82 269.3 In-house 3-235 (235) alignment 
Range on Protein: 2-232
Range on HMM: 3-235/235.0
EKNRYANIIAYDHSRVILepdSAGDKICDYINASYLHGFDgSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWP---DVSREY
.|||| .|..||..|| |   .  .. .|||||.|..|.. . |..||||||.  .. |||||.||||. ||||||.|.|....||.||||   . | .|
kknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDITVSVH-STE-VFADYTKRVLFLAKRSEAD-KRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAH
|||.| .  ...   ..|| |.| | |. | . ||.| |||.| |||.|||......| . .||. ..   |||.|||||||||||| ..|.|..|.|..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

REKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILE
.|..||....|...|. |..|||..|||||...||||
aeeevdvlqivkelRkqRpgmvqsleqYiflykaile
DSPc_SM00195 2-233 4.4e-81 267.4 In-house 28-261 (263) alignment 
Range on Protein: 2-233
Range on HMM: 28-261/263.0
EKNRYANIIAYDHSRVILEPDSAGdKICDYINASYLHGFdGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDV---SREY
.|||| ||. |||.||.|...    .  |||||.|. |   . |.|||||||    . |||||.|.||. .|||||. .|..| ||..|||.    . ..
sknRyknilpydhtrVklkkeekk.egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketf

GDITVSVHSTEVFA-DYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHRE
|.|.| . ..|    ....|.| | |  . ..| | |.... |||.|||.... || . ..|.  .   ||||||||||||||||....|| .|.. ..|
gkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleee

KKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEA
||||| . |...|  |..||||.|||.|...||||.
kkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 2-233 4.4e-81 267.4 In-house 28-261 (263) alignment 
Range on Protein: 2-233
Range on HMM: 28-261/263.0
EKNRYANIIAYDHSRVILEPDSAGdKICDYINASYLHGFdGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDV---SREY
.|||| ||. |||.||.|...    .  |||||.|. |   . |.|||||||    . |||||.|.||. .|||||. .|..| ||..|||.    . ..
sknRyknilpydhtrVklkkeekk.egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketf

GDITVSVHSTEVFA-DYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHRE
|.|.| . ..|    ....|.| | |  . ..| | |.... |||.|||.... || . ..|.  .   ||||||||||||||||....|| .|.. ..|
gkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleee

KKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEA
||||| . |...|  |..||||.|||.|...||||.
kkvdifeivkelRkqRpgmvqtleqYlfiyeailey
0039614 (Phosphotyrosine protein) phosphatases II 2-236 3.1e-80 265.1 In-house 58-291 (297) alignment 
Range on Protein: 2-236
Range on HMM: 58-291/297.0
EKNRYANIIAYDHSRVILEPDSAGDKICDYINASYLHGFDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKvKCHQYWPDVSREYGDI
.|||| .|..||||||.| |    |  .|||||||. |.|   ...||||||   .. |||||.|.... ||||||.|.| .. ||.||||. . .|||.
dknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdf

TVSVHSTEVFADYTKRVLFLAKrsEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPY--GSGPIVVHCSAGVGRTGAYIAIDAMLNQAHREKK
|| . ..|. ..|| |.| . .  .   |.| ....| ||| |||.... .| | ..|.  . .  ..||..|||||||||||..||.. ||.| ..|..
tvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekegg

VDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVC
||... |...|. | ..|||..||.|...|.||   .
vdvleavkelreqRpgavqtpsqyrflydallellkr
0043336 (Phosphotyrosine protein) phosphatases II 2-232 4e-80 264.5 In-house 47-275 (278) alignment 
Range on Protein: 2-232
Range on HMM: 47-275/278.0
EKNRYANIIAYDHSRVILEPDSAGDKiCDYINASYLHGFDGSFKaYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVSREYGDI
.|||| .|..||||||.|....     .|||||||. |.. . | .||||||   .. |||||.|.... .|||||.|.| ..|||.||||. | .|||.
dknrykdilpydhsrvklsllggdld.sdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdf

TVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHREKKVD
|| . ..|...||| |.| . .. .  .|.|...|.. ||| ||| . . .| | |.|.  ..  .||..|||||||||||..||.. .|.|...|..||
tvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvd

IYKYVEMMRRDRIHMVQTEEQYIFVHMAILE
... |...|. | ..|||..||.|...|.||
leeavkelreqRpgavqtpsqyrflyealle
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2-232 5.7e-79 260.2 In-house 49-277 (288) alignment 
Range on Protein: 2-232
Range on HMM: 49-277/288.0
EKNRYANIIAYDHSRVILEPDSAgDKICDYINASYLHGfDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVSR--EYG
.|||| ||..||. || |.      .  |||||||..| ... |.|||||||. ..  |||......|.  |||||.| | .| ||..||||  .  .||
kknRyrnilpyDekrvklkklee.eagaDYinasyidg.ekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyG

DITVSVHSTEVFADYTKRVLFLAkrSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHREKK
..|| . ...   |...| | |    . ..... |.....|||.|||. .. .|.....|. .|.  .|||.||||||||||| .||.||.... ..|..
svtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedy

VDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILE
.|.   |. .|. |  .|||..||.|.. ..|.
iDvagtvaklRkqRallvqtlkqYefiyevlls
0045450 (Phosphotyrosine protein) phosphatases II 2-232 1.2e-78 260.3 In-house 57-302 (307) alignment 
Range on Protein: 2-232
Range on HMM: 57-302/307.0
EKNRYANIIAYDHSRVILEPDSAGDKICDYINASYL--------HGFDGsFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPD
.|||| .|..|||.||.| . .  .. .|||||||         .|.|   ...||||||   .. |||||.|.... ||||||.|.| ...||.|||||
dknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPd

V--SREYGDITVSVHSTEVFADYTKRVLFLAKR-SEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNP--YGSGPIVVHCSAGVGRTGAYIAID
   . .||..|| . |.|. ..|| |.| .     .   |.| ..|.| ||| |||..   .| | ..|.. .    ..||..|||||||||||..||..
egeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaay

AMLNQAHREKK---VDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILE
 || | ..|..   ||... |...|. | ..||..|||.|...|.||
lmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2-244 4.2e-75 247.6 In-house 53-294 (297) alignment 
Range on Protein: 2-244
Range on HMM: 53-294/297.0
EKNRYANIIAYDHSRVILEpdSAGDK-ICDYINASYLHGFDGsfkAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKvKCHQYWPDVS-REYG
||.||.||. || |||.|.  . .|.   ||.|||...|.      .|.|| |  |.  |||.|...|. ..||||....|..| || .||.| .  ..|
eksRYkniLPydssRvkLa..ivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfG

DITVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQ--HATAVLGFRKKVNANNP-YGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHR
|..| ..|..    . || | ..| .   .| | | .|. |||| |..  .|...| . . |. .     .||..|||.||||||| ...|| .. .|.|
dvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakr

EKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEVPVQ
||.|||...|...|..| ..|||.||| ||. |.||| .. .|.....
ekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas
0040439 (Phosphotyrosine protein) phosphatases II 2-233 4.9e-75 247.6 In-house 13-245 (249) alignment 
Range on Protein: 2-233
Range on HMM: 13-245/249.0
EKNRYANIIAYDHSRVILEPDSAgDKICDYINASYLHGFDGSFKaYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWP-DVSREYGD
.|||| .|..||||||.|.. .     .|||||||..|.. . . .||||||   .. |||||.|.... ||||||.|.| ...||.|||| . | ||||
dknrypdilpydhsrvklsilpg.lflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygd

ITVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPY--GSGPIVVHCSAGVGRTGAYIAIDAMLNQAHREK
.|| . |.||..||| |.| | .  . ..|.| ....| ||| |||..   .| | ..|.  . .   .||..|||||||||||..||.. ||.| ..|.
ftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekel

KVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEA
.||.. .|...|. | ..||..|||.|...|.|| 
gvdleeavkllrsqRpgavqnpeqyrflyeallel
0045098 (Phosphotyrosine protein) phosphatases II 2-234 5.7e-75 247.5 In-house 35-272 (278) alignment 
Range on Protein: 2-234
Range on HMM: 35-272/278.0
EKNRYANIIAYDHSRVIlepdsagdkicDYINASYLHGFdGsfKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVS-REYGD
.|||| .|..||||||.           |||||||..|. .  |..||||||    . |||||.|.... ||||||.|.| ...||.||||. .  .|||
dknRykdilpydhsrVk...........dYINAsyidgy.p..kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygd

ITVSVHSTEVFADYTKRVLFLAKR----SEADKRHVVQLHFTVWPDKGVPQHA--TAVLGFRKKVNANNPY-------------GSGPIVVHCSAGVGRT
.|| . |.||. |||.|.| .       ..  .|.| .||.. ||| ||| .   . .| . . ... . .             ..||..||||||||||
ftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRt

GAYIAIDAMLNQAhrEKKVDIYKYVEMMRRDRIH-MVQTEEQYIFVHMAILEAT
|...|.. || .   |..||....|...|. | . .||..|||.|.....||  
Gtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2-232 8.3e-74 243.1 In-house 30-266 (274) alignment 
Range on Protein: 2-232
Range on HMM: 30-266/274.0
EKNRYANIIAYDHSRVILEPDSAGDKICDYINASYLHGFDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVSR-----
.|||| .|.  ..|||.||..|. |.  .|||| |..|.|.  |||.|||||..    ||||||.||.. ||||||.|||... ||..|.||        
tknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeise

EYGDITVSVHSTEVFADYTKRVLFLAKRSEadKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANN---PYGSGPIVVHCSAGVGRTGAYIAIDAMLNQ
.|||. . |...    ||. | | | . ..  .|.|.   .| |||. .|..|...| . ..|. ..       .|.|||||||.||||..|||.  ..|
rygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrq

AHREKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILE
 ..|..||. | |  .| ||  ||||.||| ..| |. .
lreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
0042113 (Phosphotyrosine protein) phosphatases II 2-232 1e-73 243.0 In-house 11-241 (245) alignment 
Range on Protein: 2-232
Range on HMM: 11-241/245.0
EKNRYANIIAYDHSRVILEPDSAgDKICDYINASYLHGFDGSFKaYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWP-DVSREYGD
.|||| .|..|||.||.| ||.  |  .||||||| .|.. . | .||||||   .. |||||.|.... .|||||.. | ..|||.|||| . | .|||
dknrysdilpydhtrvklspdgg.dldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygd

ITVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNP-YGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHREKK
.|| . |.|...||| |.| . .  .  .|.|...|.. ||| ||| .   .| | . |.      ..||..|||||||||||..||.. ||.|...|..
ftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelg

VDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILE
|.... |...|. | ..|||..||.|...|.||
vsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2-254 4.9e-73 241.2 In-house 63-311 (319) alignment 
Range on Protein: 2-254
Range on HMM: 63-311/319.0
EKNRYANIIAYDHSRVILEPdSAGDKICDYINASYLHGFDgSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTnlkeseKVKCHQYWPD-VSREYGD
.|||. ||.|.|...| ||.   |    ||||||.. |.  . . |||.|||   .  |||||||. ... ||.||      | || ||||  .  ... 
dknriinilafdknvvkler.liGeefsdyinasfvtGyq.rkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeer

ITVSVHSTEVFADYTKRVLFLAK-RSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVN--ANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHRE
  |.|.| |  |.|. | . |..   | |.|.. | ||  |||.|||.... .. . |||.   .   .  .|||||||||||||.||..|..|.. ..|
fkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkee

KKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEVPVQDLSRTITKLS
|.||.|..|. .|..| ..||   || |...|.||  . |...| . |.   . .||
kqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleels
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2-254 2.8e-72 238.6 In-house 27-275 (284) alignment 
Range on Protein: 2-254
Range on HMM: 27-275/284.0
EKNRYANIIAYDHSRVILEPdSAGDKICDYINASYLHGFDgSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTnlkeseKVKCHQYWPD-VSREYGD
.|||. .|.|.|...| ||.   |    ||||||.. |.  . . |||||||   .  |||||||. ... ||.||      | || ||||  .  ... 
dknrighilafdknvvkler.liGeefsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeer

ITVSVHSTEVFADYTKRVLFLAK-RSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVN--ANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHRE
  |.|.| |  ..|. | . |..   | |.|.. | ||  |||.|||.... .. . |||.   .   .  .|||||||||||||.||..|..|.. ..|
fkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkee

KKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEVPVQDLSRTITKLS
|.||.|..|. .|..| ..||   || |...|.||  . |...| . |.   . .||
kqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleels
0037934 (Phosphotyrosine protein) phosphatases II 2-232 1.3e-71 236.3 In-house 12-240 (243) alignment 
Range on Protein: 2-232
Range on HMM: 12-240/243.0
EKNRYANIIAYDHSRVILepdsaGDkiCDYINASYLHGFDGsfkaYIATQGPVVASFVD----FWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPdVSRE
.|||| .|..||||||.|     ..  .|||||..  ....    .||||||   .. |    ||||.|.... ||||||.|.| ...||.||||  . .
sknrysdilpydhsrvkl.....eg..sdyinanliyvtpr....liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.gevt

YGDITVSVHSTEVFADYTKRVLFLAKRS-EADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNAN--------NPYGSGPIVVHCSAGVGRTGAYIAID
|||.|| . |.|...||| |.| |   . .  .|.|...|.. ||| |||.. . .| | ..|..         .  ..||..|||||||||||..||..
ygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaay

AMLNQAhrekKVDIYKYVEMMRRDRIH-MVQTEEQYIFVHMAILE
 || .     .||....|...|. | . .|||..||.|...|.||
lmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2-253 1.4e-71 236.3 In-house 50-307 (325) alignment 
Range on Protein: 2-253
Range on HMM: 50-307/325.0
EKNRYANIIAYDHSRVILEPDsAGDKICDYINASYLHGFDGSfKAYIATQGPVVASFVDFWRMI--WQekSAVIVMLTNLkESEKVKCHQYWPDV---SR
.|||. |..|.|.|||.||     |  .||||||||. . .  . ..|.| |  |.  |.||..  |.  ..|.|.|  | . .| .| .|||.    |.
aknrfknvvaldksrvvletk.kddpssdyinasylrddkkk.dvflaaqaPltatindlWrlvldWr..csvvvvlnel.dlgkdrcavywpkemgksk

EYGDITVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNA------NNPYGSGPIVVHCSAGVGRTGAYIAIDAM
..| . |.. . | ..|| .||| . . .. . | | |...  |.| ||... .... . . |.|       |  .|.||.|||||||||||..|.. ..
tfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysa

LNQAHREKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEVPVQDLSRTITKL
|..   | .|||...|. .|.||  ||.| .|||... |. || ..|||.|||  .   .. |
lakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklssl
subfamily_PTPN9_pd Subfamily PTPN9 2-233 1.8e-71 235.6 In-house 44-289 (297) alignment 
Range on Protein: 2-233
Range on HMM: 44-289/297.0
EKNRYANIIAYDHSRVILEPdSAGDKICDYINASYLHGFDGSfKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWP---DVSREY
|||||.... ||..|| |.    .|.  |||||... |.    ||.||||||.   . |||||.|...  |||| | . |  ..|| ||||   . | |.
eknrytdvlcydetrvvlak.vdedeasdyinanfvdGykqk.kafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaef

GDITVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNAN-------------NPYGSGPIVVHCSAGVGRTGAYI
||..||. ..|.  ||..||| . .  . ..|.|.   |. ||| |||. |...| ...||  .              .    |||||||||.||||..|
gdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfi

AIDAMLNQAHREKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEA
..|  |.. ... .||. . |...|  | ...||.||| | ..|.|| 
tldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_PTPN12_pd Subfamily PTPN12 2-233 1.6e-70 232.2 In-house 42-276 (290) alignment 
Range on Protein: 2-233
Range on HMM: 42-276/290.0
EKNRYANIIAYDHSRVILEPDSAGDkICDYINASYLHGFDGSfKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDV---SREY
.|||| .|. ||.||| |. ..  .   |||||....| .|. ..|||.|||. .   |||||||. .  ..||. .. | .| ||..|||.    . |.
kknrykDilPydksrvelskieeee.gsdYinanfikgvegk.leyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelef

GDITVSVHSTEVFA-DYTKRVLFLAKRseADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDA---MLNQA
|...|.... . .  |.. | | . ..   ..|.| |.|.| |||.|||. |. .| . ..|.  .   . |.||||||||||||. ||||    .|.. 
gefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkae

HREKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEA
. ....|... |  .|..|  .|||.||| .|..|..| 
kipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2-234 3e-70 231.4 In-house 48-283 (290) alignment 
Range on Protein: 2-234
Range on HMM: 48-283/290.0
EKNRYANIIAYDHSRVILEPDSAG-DKICDYINASYLHGFDGSfKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDV-SREYG
..||.|||. ||  |..| | |   |   .||||.|..|.  . |.||||||||    ||||..|||||...|||||| .|..||||.|||||  ...||
llnRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkayg

DITVSVHSTEVFADYTKRVLFLAKRSE-ADKRHVVQLHFTVWPDKG-VPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHRE
 ... ... |.. .|..| | . .... ..|..|.|...| |...| |....| .| ... .. .   | ..||||||..|||.. ..|..  .|... |
efsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkckte

KKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEAT
  .|... .. .|  .  .|||..|| ...  .|.. 
gvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2-241 1.2e-69 229.5 In-house 49-285 (287) alignment 
Range on Protein: 2-241
Range on HMM: 49-285/287.0
EKNRYANIIAYDHSRVILEpdsagDKICDYINASYLHGFDGSfKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVS-REYGD
.|||...|. .|  ||.|.     ..  |||||... |.  . ||.|....|..   ..||..|....  .||||...||... .|.||||. .   .|.
dknRltqilvpdnyrvllk.....gehpdyinavfidgykek.kafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGe

ITVSVHSTEVFADYTKRVLFLAKRS-EADKRHVVQLHFTVWPDKG-VPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHREK
 .... . || |.|..| | . ... ..||..|.| ..| |...| |....| .| . ... ..   | ..||||||..|||.. ..|..  .|....| 
yniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteG

KVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEV
 .|... .. .|  . ..||| |||.|.  ..||   ...| .
viDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
subfamily_PTPN3_pd Subfamily PTPN3 2-233 2.1e-67 222.0 In-house 43-274 (280) alignment 
Range on Protein: 2-233
Range on HMM: 43-274/280.0
EKNRYANIIAYDHSRVILEPDSagdKicDYINASYLHG-FDG--SFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVS--R
.|||| .|..||. ||.|.  .   .  |||||.|.    ..    . |||||||.  .  |||.|.|..|| .|||||.| |. .||||||||. .   
sknryrdilpydatrvklkese...t..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedel

EYGDITVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHR
|||...| .....    |  | | | .... ..|...|| .. |||.|||.... .| | ..|..     . |.|||||||.|||| .|...  |    .
eygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalaliea

EKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEA
...| . . | .||  |  .|||..|| ||  |||..
aepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2-273 1.1e-65 216.6 In-house 47-275 (392) alignment 
Range on Protein: 2-273
Range on HMM: 47-275/392.0
EKNRYANIIAYDHSRVILEP-DSAGDKicDYINASYLHGFDGSfKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEkvkchqywpdvsreygd
.|||| ||. || .||.||  |   |.  ||.||||...||   |||||.||| .||. |||||..||. . |.|.|.||| .                 
kknryknilpydsarvkleviddipds..dylnasyipsfdne.kayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.................

itvsvhstevfadytkrvlflakrSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHREKKV
                           |.| | | ||| ||||.||.|....| | |.|.|.    . |...||||||||||  |.||... .|.. . |
........................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmv

DIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEVPVQDLSRTITKLSAVVPGKGITGFADEFQRLR
|....|  .|| | .||||.||| |.. |.||  .  || .||  ..  ...||. . |.. .    ||. |.
dvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlstssdGdvrskqlkefrslk
subfamily_PTPN13_pd Subfamily PTPN13 2-233 2.8e-65 215.3 In-house 39-268 (273) alignment 
Range on Protein: 2-233
Range on HMM: 39-268/273.0
EKNRYANIIAYDHSRVILEPDSAgdkicdYINASYLHGF-DGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVSRE---
.|||| |.. ||..||.|. ...      |||||...   .     |||.|||.  .  |||.|.|. |. ||.|.|. ||..|||||.|||.  ..   
dknryrnvlPydetrvklgdegg......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklk

-YGDITVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPyGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHR
 .. ..|..  ..   ... | | . .   .. |.|..|.|. ||| |||..|. .| | ..|.  .   .||||||||||.||.|..|.||..|.  .|
vsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlglier

EKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEA
.|..|. . |. .|. |  .|||..|||||. ||||.
dkefdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2-250 2.6e-63 208.5 In-house 35-282 (283) alignment 
Range on Protein: 2-250
Range on HMM: 35-282/283.0
EKNRYANIIAYDHSRVILEPDSAgdkicDYINASYLH--GFDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPD-VSREY
.|||. .|...|  || |...|      |||||...     .   | ||..|.|.    ||||.|...|| . |||||.|.| ...|| ||||   | .|
rknrnqeivpadqwrvelksesr.....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedy

GDITVSVHSTEVFADYTKRVLFLAKRSEADKRHVvQLHFT--VWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHR
|. ||...       .... | | . | | .  .   |.    | . |      ... | | .   .    ||||||||.|.|||...||. | ...|  
Geftvtlrkettsnsfiikelllrvnssakstll.lahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdalt

EKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEVPVQDLSRTI
|  ||... |..|| .|. .||| .|| .|| ..|| ..||.|..   ||  ||
esvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqsti
subfamily_PTPRN_pd Subfamily PTPRN 2-232 6.4e-63 207.2 In-house 58-290 (297) alignment 
Range on Protein: 2-232
Range on HMM: 58-290/297.0
EKNRYANIIAYDHSRVILEPDSAGDKiCDYINASYLHGFDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVSRE-YGD
.|||......|||||| |. ... .|  |||||| .   |    ||||||||. ..  |||.|.|.. ..|||.||.|.|..  .|..||||   | |. 
kknrskavlpydhsrvklkeeasaek.sdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhi

ITVSVHSTEVFA-DYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHRE-K
  | . |  ... ||  | ..|      . | | |.||  ||..|||  | ..| ||.|||      | |||||||.|.||||.||.|| .||.  .  |
yevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvk

KVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILE
..||   .| .| .| ..|.|..|. |. .|. |
eidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2-246 1.7e-62 206.4 In-house 50-291 (439) alignment 
Range on Protein: 2-246
Range on HMM: 50-291/439.0
EKNRYANIIAYDHSRVILEpDSAGDKICDYINASYLHGFDGSfKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKvkchqYWPDVSR-EYGD
 |||| .. |.||.||.|. .  |     |||| |..|.    | |||||||   .  ||||.....|.. ||||||| || |     |||  .   |||
tknrykdvgafdhtrvtlq.eipgvphshyinanyikGyydd.klyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygd

ITVSVHSTEVFADYTKRVL-FLAKRSEAD-KRHVVQLHFTVWPDKGVPQHATAVLGFRKKVN-ANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHRE
|.| |     . .|. | .  . .|  .. .| |.|.|.. |||| || .|. || | . .| ||.    ||.||||||||||||. ||.|  |.| . |
iavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlkle

KKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEVPVQDL
.||||   |...|..| .|||.  ||.|.. |.||  | |.. | ....
nkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef
subfamily_PTPN23_pd Subfamily PTPN23 2-233 3e-59 195.2 In-house 45-279 (288) alignment 
Range on Protein: 2-233
Range on HMM: 45-279/288.0
EKNRYANIIAYDHSRVILEpdsagDKICDYINASYLHGFDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPD---VSREY
||||. .|. |||.|| |.     ..  ||||||....       .||||.|   .  |||.|....|| |||||.. .| .| |...|||     . ..
eknrsrdilPyDhnRvklr.....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkf

GDITVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNA----NNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQA
||..|...|..    . .||| |  ...  ...|. |..| ||. |||.    .| | ..|..    ..     |.||||||||||||..  . | ... 
gdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrel

HREK-KVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEA
....  .|| . |. .|..| .|||..||. |.  |.|||
ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_PTPN14_pd Subfamily PTPN14 2-231 3.4e-53 175.6 In-house 51-293 (300) alignment 
Range on Protein: 2-231
Range on HMM: 51-293/300.0
EKNRYANIIAYDHSRVILEPDSAGdkICDYINASYLHGF-DGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDV-----S
||||. ... |...|| | |        .||||| ..    |. . ||..|||.     |||.|.|... ..|||||. .|. | |...|.|.      .
eknrfkdvlPyednrvelsptken..stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkkt

REYGDITVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVN-------ANNP--YGSGPIVVHCSAGVGRTGAYIA
 |.|   |. . .|    .. . | |      ..| |. | .| |||.|||.  .  | . ..|.        ...    . |..|||||||||||  | 
vefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlil

IDAMLNQAHREKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAIL
 | ...  . ....|| | ....|. | ..|||  || ||. ...
sdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli
0041856 (Phosphotyrosine protein) phosphatases II 2-242 6.8e-51 167.7 In-house 3-179 (182) alignment 
Range on Protein: 2-242
Range on HMM: 3-179/182.0
EKNRYANIIAYDHSRvilepdsagdkICDYINASYLHGFDGSFKaYIATQGPVVASFVDFWRMIWQEKSAVIVMLTnlkesekvkCHQYWPdvsreygdi
.|||| .|. |||||            .|||||... |   . . .||||||   .. ||.||.....  .||.||         ...|||         
dknrysdilpydhsr...........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

tvsvhstevfadytkrvlflakrsEADKRHVVQLHFTVWPDKGVPQhATAVLGFRKKVNAnnpyGSGPIVVHCSAGVGRTGAYIAIDAMLNQahrekKVD
                        |  .|...|.... ||| |||     .| | ..|..     .||..|||||||||||...|.. |. .     .|.
........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvs

IYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEVP
... |...|. | .||.|..||.|...|.||   ...|...
leeavklvrsrRpgmvitpnqyfflqlallellllkktrpk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2-233 2.8e-48 159.1 In-house 58-282 (290) alignment 
Range on Protein: 2-233
Range on HMM: 58-282/290.0
EKNRYANIIAYDHSRVILEPDSAGdkicDYINASYLHGFDGSFkayIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVSRE---Y
.|||| ...  | .||||.    |    ||. | |..| .  |   | |||.. .. .|.|||. ||| |.|||| .| |  | ||.||.|. . |   .
kknrykdvvcndktrvilkdGydG....dyvhanyvkGlkamf...iltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltf

GDITVSV-HSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANnpygSGPIVVHCSAGVGRTGAYIAIDAMLNQAHRE
|.|||    ...  |.  |..| . .. .  .  .  |.   |||| |.. . |.|   . .       |||.|||||||.||||...||.. |.     
GeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievglqilldG

KKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEA
|..|. . |  .|. |.  || . ||. .  ..|. 
keldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2-231 1.3e-47 157.0 In-house 40-274 (287) alignment 
Range on Protein: 2-231
Range on HMM: 40-274/287.0
EKNRYANIIAYDHSRVILEpdSAGDKICDYINASYLHGFDGSfKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVS--REYG
.|||||... .|..||.|     |..  ||||| |. ..    .|.||.|||. |.  ||||......||.....|   |  . ||..|||.       |
kknryadvlPiddtrvlls..aegelGsdyinanyvasytdd.eafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

DITVSVHS-TEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKV-----NANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQ
  .| . . .    .|. | | |..    . | | ||..  ||||...  | ... |  .|      | .  . ||.|||...|.||.| ..|. .....
GysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsr

AHREKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAIL
     .||. . |  .|  |  .||.  |. ..  |. 
ledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2-232 2.6e-42 139.9 In-house 43-275 (307) alignment 
Range on Protein: 2-232
Range on HMM: 43-275/307.0
EKNRYANIIAYDHSRVILEPDSAGdkiCDYINASYLhGFDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVSR---EY
.|||| .. . |..|.... | .     ||| | || |     | .|..|||  ..  .|| |. |||   ..|| .. |  |.||.|||| .      .
dknryqdvkcqdkgrivvkfdgla...sdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvf

GDI--TVSVH--STEVFA--DYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNannpYGSGPIVVHCSAGVGRTGAYIAIDAMLN
|.   |.||    .. .|  .    |  |      . | . .| .. |||.||||   . . . . |.    |   |.||||||||||.|. .||  . .
geapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr....ydtnpvvvhcsaGvGrsGtivaislvqd

QAH-REKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILE
.    .   |. | || .| .| . .||| ||...|  .||
kmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2-232 5.6e-42 138.6 In-house 35-257 (267) alignment 
Range on Protein: 2-232
Range on HMM: 35-257/267.0
EKNRYANIIAYDHSRVILEpDSAGDkicdYINASYLHGFDGSfKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEkvkCHQYWPDV---SREY
|.||. . . ||..||||  ..  .    ||||||..|.    .|.|.||.|.  .  ||. .| ..| .|||.||.  . .    ...||     ...|
ernrlddnlpyddtrvilr.tkeee....yinasyvegyktk.nafivtqdplkntitdfltvihdqkvpvivlltkvftdn...irlfwPPkmgqakky

GDITVSVHSTEVFADYTKRVLFLAKRSEAdkRHVVQL-HFTVWPDKGV-PQHATAVLGFRKKVNANNpyGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHR
 |.||     .   ||   .| |  . |.   | | | ..  |  .     .   ..|   | . .|  |. |.||.||.||||.|... ||..|..| .
qdltvehslekeendyqiitlelkfknes..ahnvtlyyykkwnintnnkpylkplfgilaknqlen..gnrPlvvacsdGvGrsGtflvidsqlerakt

EKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILE
|  .||....  .|  || .|.| |.||..|  . |
egvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2-232 2.7e-38 126.4 In-house 50-285 (305) alignment 
Range on Protein: 2-232
Range on HMM: 50-285/305.0
EKNRYANIIAYDHSRVILEPDSAgdkiCDYINASYLHGfDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVSRE----
.|||| ..   |. || ||.        .|| | |.       | .| || |.  .  ||| | .|.|   | || ||.|    ||..|..   ..    
gknrykdvgcldnnrvklegpwp....heyihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

---YGDITVSVHSTEV--FADYTK----RVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANnpygSGPIVVHCSAGVGRTGAYIAID
      |.| . |..   | . .|    .  .. . . ...|.| . |.  |||.|||   .|.| . .|  .      ||||||||||.||||. . ..
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps....kgpivvhcsagigrtgsvvmle

AMLNQAHREKKVD-IYKYVEMMRRDRIHMVQTEEQYIFVHMAILE
 .|.|    ....   | .  .| .|   .||..||.|||  ||.
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2-235 3.8e-37 122.5 In-house 39-270 (281) alignment 
Range on Protein: 2-235
Range on HMM: 39-270/281.0
EKNRYANIIAYDHSRVILEPDSAGDKICDYINASYLHGFdGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVS---REY
.||||.|| . | ||| |. .    .  ||| | |..      . || ||||   .  |||||||||... |||| .. |... || .|.|  .    ..
kknrylnipcldisrvqlkvkmpnknstdyihanyirsp.flkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqf

GDITVSVHSTEVFADYTKRVLFLAkrSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANnpygSGPIVVHCSAGVGRTGAYIAIDAMLNQAHREK
  ..||   . |        | |.   | . | . .  .  |||  ||. .  .|   .|. |     | | |.||||||||.|. .|..  |.  |   
dklsvsyedstvnkslvttrlnls..yegetrlithwlwkewpdwqvpessevmlkilrkirar....stppvihcsagvgrsgtlmaveialqsihshf

K-VDIYKYVEMMRR-DRIHMVQTEEQYIFVHMAILEATV
   || . |  .|   |   ||| .||...   .|.  |
tlpdikqivshlrvtgraasvqtlqqymliwkvlldfgv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2-241 4.8e-36 118.9 In-house 54-296 (310) alignment 
Range on Protein: 2-241
Range on HMM: 54-296/310.0
EKNRYANIIAYDHSRVILEPDSAgdKICDYINASYLHGfDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPD--VSREYG
 ||||....  | ||| |. | .  .  ||| | |..  .   ...| .|||.  . .||||||.||..  |..| .  |  . ||  |||   |.  ||
hknrysdvvcldtsrvklkidks..ryedyihanyvkt.nylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

DITVSV--HSTEVFADYTKRVLFLAKRSEADKR-------HVVQLHFTVWPDKGVPQHATAVLGFRkkVNANNPygSGPIVVHCSAGVGRTGAYIAIDAM
 | |.    |.| |      | |.      |..        |  ...  |||.|||.     .  |  . |.     || |||||||..|... .|..  
cirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqr..llaqvr..hgpcvvhcsagkdrlyvvvalklk

LNQAHREKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILeATVCGNTEV
.....| .|||. . .  ....|.  .||| ||.....  . . . |.|||
idkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargetev
subfamily_ptpA1_pd Subfamily ptpA1 2-199 5.2e-33 109.4 In-house 49-262 (418) alignment 
Range on Protein: 2-199
Range on HMM: 49-262/418.0
EKNRYANIIAYDHSRVILEPDsAGDKICDYINASYLHGFdgSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDV-SRE---
 ||||.||.  .|.|| |.      .  ||||| |. |     | .|.||||.  .  |||||.|...  .||||.   |  ..|| .|||.    |   
sknrytnilpvnhtrvqlkki.qdkegsdyinanyidga..ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfs

-YGD-----ITVSVHSTEVFADYTKRVLFLAKR--SEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKV-NANN---P--YGSGPIVVHCSAGVGRTGA
 ||.      | ||   ||  |  . ..    |   | . | . | ..  |||. .|.|.  .  . . . | .|   |      ||.|||||||||||.
iygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgt

YIAIDAMLNQ-AHREKK
. .   |...  |  |.
fctavimmkkldhyfkq
subfamily_CG42327_pd Subfamily CG42327 2-155 6.1e-28 92.4 In-house 30-186 (319) alignment 
Range on Protein: 2-155
Range on HMM: 30-186/319.0
EKNRYANIIAYDHSRVILEPDSAGDKiCDYINASYLHGFDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPD-----VSR
.|.|..|..   ..||.|.  .  ||   |..|||. |.| .   |||.| .   |  ||||..|. .| ||| ||.| |    .| .|.|        .
dksrvinvvPlPetrvvlqrigdddk.deyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

EYGDITVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFtVWPDKGVPQHATAVLGF
 |||| |..   ||   |    | | .  .   |..    .  |.. .|| . .|..  
lyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliam
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2-233 6.9e-26 85.7 In-house 45-275 (312) alignment 
Range on Protein: 2-233
Range on HMM: 45-275/312.0
EKNRYANIIAYDHSRVILepdsAGDKIcDYINASYLHGFdGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVS------
. ||| ||  .|  |  |    |||.   || | ...      . ...||||.  . . ||..     |. |..|. . |    || .|  |.       
dlnrypniqcwdrgrftl....agden.fyihanfvkic.tkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdle

--REYGDITVSVHSTEV-FADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNpygsGPIVVHCSAGVGRTGAYIAIDAMLN
  | | .    .          |.||| .  ..  .. .. .  .. |||.|.|.   . | .   |. ..     |.. ||||||||||. . |..|. 
dhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk....kpviahcsagvgrtgtlaliesmia

QAHREKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEA
     .| .. .   ..|.||   |..  ||...  ..|| 
alrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
subfamily_egg_pd Subfamily egg 2-239 7.2e-26 85.6 In-house 42-277 (307) alignment 
Range on Protein: 2-239
Range on HMM: 42-277/307.0
EKNRYANIIAYDHSRVILEPdSAGDKICDYINASYLHGfDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEkvKCHQYWPDVSREYGDI
|| |   .   | ||| ||    |  . |.| | ...| .  .  .| .| |.  .  |||||..||.   |||||  ||||  .|. |||    .   .
ekarskrvhckdssrvklel.rrGqylddfihanrvkG.kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkese..rceyywpkaesdslvt

-TVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWpDKGVPQHATAVLGFRKKVNANNpyGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHRE--K
   |.. . .  | .   ||   .      .  ...   |    | . .     .|    . |   | |.||..  || .... .||.  | .  |    
vpGslrienlkvdskadplfrvtklklvGgddeerflehw.qgdvnnssdvysplrvlrklrn..lskpvvvqdilGvskaatlvaieiallsllrGpit

KVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAIL--EATVCGNT
|  . . | ..|. |   |..  .|.||.  .|     | |..
kslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsa
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2-233 1e-19 65.3 In-house 49-278 (303) alignment 
Range on Protein: 2-233
Range on HMM: 49-278/303.0
EKNRYANIIAYDHSRVILEpDSAgdkicdYINASYLHgFDGSFKAyIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVS--REYG
.|||....|  |||.| |  ||.      || ||||. .| | || | || |.  .  |||.|| ..|  ....|    | .|.  .  .|      .. 
dknrfvdvicldhskvkls.dss......yihasyle.ldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfe

DITVSV---HSTEVFADYTKRVLFLakrSEADKRHVV-QLHFTVWPDKGVPQHATA--VLGFRKKVNANNPYG-SGPIVVHCSAGVGRTGAYIAIDAMLN
. .. |   .  |.   .. .|| .   |. | .  .   |.  || . .| ....  |    .       |  | | |    .|.||.|..  ...   
ersirvgefkrvelgdgwvlkvlsv...sngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahl

QAHREK-KVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEA
  | |.  .|. | .|..|  |.| ||   |. .|.  . | 
slhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2-231 3.8e-19 63.2 In-house 53-282 (302) alignment 
Range on Protein: 2-231
Range on HMM: 53-282/302.0
EKNRYANIIAYDHSRVILEPDSAgdkicDYINASYLHGFDGSfKAYIATQGPVVASF---VDFWRMIWQEKSAVIVMLTNLKESEKvKCHQYWP---DVS
.||.  .. ..|. .|.||         .|.||| ..  . . .  | .| |.| |     .||||..||| . .|.|   .| .|   ....|   .  
kknqsedvpildsnlvkleaepd.....syvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdy

REYGDITVSVHSTEVFADYTKR-VLFL--AKRSEADKRHVvqLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLN
 |||.. | .   |   . ..| |. .     |..    |   ..| |..| ||.. ...    .|| |..  .. ..|.    |.|| || ..  . ..
keygkmfvNnrkVekaeeektryviEvlPegcsnsvlanv..yvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavave

QAHREKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAIL
. ...|.. |   |. .| .| ..|.. .||.....|.|
klqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 2-85 7.8e-11 36.1 In-house 39-125 (347) alignment 
Range on Protein: 2-85
Range on HMM: 39-125/347.0
EKNRYANIIAYDHSRVILEPDS----AGDKICDYINASYLHgFDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKV
.|||  .    | .||.| |.       |..  |||||... || . | || || |.  .  |||.|.   | . .| . . .. | .
sknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeai
subfamily_Ptp69D_pd Subfamily Ptp69D 3-253 1.4e-79 262.4 In-house 51-305 (307) alignment 
Range on Protein: 3-253
Range on HMM: 51-305/307.0
KNRYANIIAYDHSRVILEPdSAGDKICDYINASYLHGFDGsFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWP-DVSREYGDI
|||| .|.|.|. ||.|..   |..  ||||||...|..  .| .|| |.|| |   ||||||.. .. .||||.||.| .. ||..||| .   .||||
knRyedikafDktRvkLkk.ingkedsdYinasfikgyke.kkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdi

TVSVHSTEVFADYTKRVLFLAKRS-----EADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHR
 | . |.|   ||..| | ..|       . |.|.||| |.| |.|  ||..|...| . ..|.  .    .||||||||||||.| ..|.| .|.| . 
lvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlka

EKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCGNTEVPVQDLSRTITKL
|.||||.. |  .|..|  .||  |||.|.. |.|. .  |.|.. |.||. .| .|
edkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 3-232 2.6e-62 205.2 In-house 23-262 (270) alignment 
Range on Protein: 3-232
Range on HMM: 23-262/270.0
KNRYANIIAYDHSRVILEPdSAGDKICDYINASYLHGFDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVSRE-----
 ||||.|.   ..||.||.    |..  |||| |..||||. |.|||..||. ..  .||||||.||.  |||.|.|.|  . || .|||  . |     
lnRyadiLPsPatRvrlee.leedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkle

YGDITVSVHSTEVFADYTKRVLFLAkrSEADKRHVVQLHFTVWPDKGVPQHAT------AVLGFRKKVN--ANNPYGSGPIVVHCSAGVGRTGAYIAIDA
.|.|.| . |.|    | .. | |   .....|..|  ... |||.|||...        .|   ..|    ..   ..|..|||||||||||  ||.| 
dgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDi

MLNQAHREKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILE
...  ...||||. . .| .|.||. .||. ||| |.. |..|
avrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 3-237 8.5e-60 197.0 In-house 43-296 (301) alignment 
Range on Protein: 3-237
Range on HMM: 43-296/301.0
KNRYANIIAYDHSRVILEPDSAGDKI-CDYINASYLHGFDGSfKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPD---VSREY
 ||. ||  ||. |.||.| .. |.   .||||||..|.  . |..||.|||.    |||||.||||| . |||.|||||. | ||.||||.    | |.
lnrfknitvyddnriilkpkpnldlcqreyinasyidgysek.kkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseef

GDITVSVHSTEVFADYTKRVLF---------------LAKRSEADKRHVVQLHFTVWPDKGV-PQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTG
| .|| .... |. |.. | |                ....|. . ..|.||. | ||. || ....| .    . . ...  | ||.|||||..|.|.|
gpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsG

AYIAIDAMLNQAHREKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCG
 |....  | |. .|  ||... .. .|| .  .|.| |||.... .| .   . 
vYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqln
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 3-232 3.2e-36 119.5 In-house 58-287 (305) alignment 
Range on Protein: 3-232
Range on HMM: 58-287/305.0
KNRYANIIAYDHSRVILEPDSagdkICDYINASYLHGFDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVSREYGDIT
||||... . |.| | |.  |     .||| | |.       | .|..|||.  .  .|| |. |.|   |||| .  |  |.|| ||||    |  .. 
knryqdvpcqdqsavkldkps....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelk

VSVHSTEV------FADYTKRVLFLAKR-SEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNpygsGPIVVHCSAGVGRTGAYIAIDAMLNQAH
  .   .|        |   ..  |    |  .|  | .|..| |||.|||    . | .   .   .     |||||||||.||||. .||. .|..  
sgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk....vpivvhcsagigrtgtivaieyilekia

REKKV-DIYKYVEMMRRDRIHMVQTEEQYIFVHMAILE
 .|..  . . |  .| .| . .|.. ||.|.|  .|.
enkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 3-235 3.5e-34 113.1 In-house 38-271 (285) alignment 
Range on Protein: 3-235
Range on HMM: 38-271/285.0
KNRYANIIAYDHSRVILEPDsagDKicDYINASYLHGFDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVSRE---YG
 ||||.. . . .||.|.     |.  ||| ||...       .||.||||.  .. |||.||.||| | ..||  | |    ||  |.|.   |   .|
lnryadvrcieetrvvlknh...dr..dyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfg

--DITVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHF--TVWPDKGVPQHATAVLGFRKKVNANNPYgSGPIVVHCSAGVGRTGAYIAIDAMLNQAH
  .||..    |  |      | . .  .|    .   |     |||.  |. |  .. . | |.  ||    ||.|||||||||| ... ||    .  
kyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk.ekpicvhcsagvgrtatfvgidyatirim

REKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATV
 . ....   |  ||  |.. ||.  |..|... ..|  .
enpniemldivremramrfqavqshmqflflyvvlmeyfi
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 3-159 9.2e-30 98.5 In-house 36-193 (297) alignment 
Range on Protein: 3-159
Range on HMM: 36-193/297.0
KNRYANIIAYDHSRVILEPDSAGdkiCDYINASYLHGFDGSFK-AYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVSREY---
|||| .|.|.| .|| |    ..    ||||| |.   |   .  || .|||. |.  |||......   ||||...|.|  . ||  |||.|  |    
knryrdilatddtrvkllrvite...rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlka

GDITVSVHStEVFADYTK---RVLFLAKRseADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKV
||. |   | ..  .. .     | |  |  ...|.|    |  |||.|||     .  |. .|
gdvvvefls.stsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqv
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 3-235 1.5e-29 98.0 In-house 46-272 (288) alignment 
Range on Protein: 3-235
Range on HMM: 46-272/288.0
KNRYANIIAYDHSRVILEpdsagDKiCDYINASYLHGFDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVSREYGDIT
..|| |.   | .|| |.     |  .|.  |. .       .  | .| |. .    .|.|. ..    ||||..| |  | |  .|.| .  |   | 
rdryenlprcditrvkls.....dd.pdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarig

VSVHSTEVFADYTKRVL---FLAKRSEADKRH-VVQLHFTVWPDKGVPQHATAVLGFRKKVNANnpygSGPIVVHCSAGVGRTGAYIAIDAMLNQAHREK
     . .  .  ....    |    | ...  | .||.  |.|.|||.   . | . . ...       |||||.||||||||. | |  .|...  . 
rlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlksl....qkPivvhssaGvGrtgtlililialeslrldd

KVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATV
 . | . .. .| .| . .||| ||..||  .||  .
flgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 3-108 6.4e-26 85.9 In-house 50-165 (350) alignment 
Range on Protein: 3-108
Range on HMM: 50-165/350.0
KNRYANIIAYDHSRVILE-----PDS--AGDKICDYINASYLHGF------DGSFKaYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQ
|||| ||. |.||||.|.     .|.     .  |||||.||.        . .|| |||||.|.   . ||...| . |  ||..||.. | .  ||..
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfk.YiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPDVSreYGDITVSVHST
||.. |  | |||| . |.
YWqegs..ydditvklask
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 3-108 4.4e-17 56.4 In-house 51-168 (349) alignment 
Range on Protein: 3-108
Range on HMM: 51-168/349.0
KNRYANIIAYDHSRVILEP-------------DSAGDKICDYINASYLHG--FDGSFKaYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKC
|||| .|. |.||||.|.              .| . |. ||||| ||.   ..  .| ||||| |. ..  ||...|  ..  ... |.. || .  ||
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekk.yiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HQYWPDVSreYGDITVSVHST
..|| . |  | .||| .  .
diywqels..ysnitvklqns
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 3-144 3.1e-12 40.6 In-house 99-234 (244) alignment 
Range on Protein: 3-144
Range on HMM: 99-234/244.0
KNRYANIIAYDHSRVILEPDSAGDkicDYINASYLhGFDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEkvkchQYWPDVSR-EY--G
||| .  . .| .|| |   | |.    |||||.. |  |    || || |.  . .|||.|. . .  |.|.|  ..| .     .||||    |.   
knregaglpfdfnrvplskgsmgn...tyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpdseplewyee

DITVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKG
||||..   . | .     | .    .  .. .  .  . ||  |
ditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdg
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 3-86 2.8e-09 30.9 In-house 37-117 (332) alignment 
Range on Protein: 3-86
Range on HMM: 37-117/332.0
KNRYANIIAYDHSRVILEPDSAGDkicDYINASYLHGFDGSfKAYIATQGPVVAS-FVDFWRMIWQEKSAVIVMLTNLKESEKVK
 ||   . ..||||| | |.   |   |. |||.. |.     ||| .| |.       ||||. . | ..|... .. | .| |
mnriphlycfdhsrvelapqdgkd...dfynaswvdgyskk.sayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 3-41 3.2e-08 27.3 In-house 50-87 (440) alignment 
Range on Protein: 3-41
Range on HMM: 50-87/440.0
KNRYANIIAYDHSRVILEpDSAGDKICDYINASYLHGFD
|||| ||.|||||||.|| .  |    |||||||. | .
knryrnilaydhsrvmle.evkgvpdsdyinasyingie
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 3-151 1.2e-06 21.6 In-house 30-160 (169) alignment 
Range on Protein: 3-151
Range on HMM: 30-160/169.0
KNRYANIIAYDHSRVILEPdSAGDKICDYINAsylhgfdgsfkayiatqgpvvasfvdfwRMIWQEKSAVIVMLTNLKESEKV----KCHQYWPDVS-RE
||| |  .|  | || |.     |  .|||||                            ||||.  ..|||.| .  . .      . .|  | |   |
knrpagplapshtrvklqr.vmedlgsdyina............................rmiwetnasvivvlgdtddknnfwpekedyqlhpavilge

-YGDiTVSVHSTEVFAdYTKRV--LF-----LAKRSEADKRHVVQLHFTVWPDKGVPQHATA
 | | .. | .  | |  |. |  ||     . . ..    ..  ||...||..||||    
wytd.slyvrtdkvha.ntsgveglfevsmvihsydddvteklsllhystwpqngvpqspvh
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 3-151 1.8e-06 20.9 In-house 29-159 (169) alignment 
Range on Protein: 3-151
Range on HMM: 29-159/169.0
KNRYANIIAYDHSRVILEPdSAGDKICDYINAsylhgfdgsfkayiatqgpvvasfvdfwRMIWQEKSAVIVMLTNLKESEKV----KCHQYWPDVS--R
||| |  .|  | || |.     |  .|||||                            ||||.  ..|||.| .  . .      . .|  | |    
knrpagplapshtrvklqr.vmedlgsdyina............................rmiwetnasvivvlGdtddknnfwpekedyqlhpavilGe

EYGDiTVSVHSTEVF------ADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATA
 | | .. | .  |           .  | . . ..   ...  ||...||..||||    
wytd.slyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvh
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 3-52 3.1e-06 21.3 In-house 51-95 (95) alignment 
Range on Protein: 3-52
Range on HMM: 51-95/95.0
KNRYANIIAYDHSRVILEpdsaGDKICDYINASYLHGFDGsFKAYIATQG
|||. ||. || .||.|       .  ||||| .. |.    ..|||.||
knrflnifpydatrvvlt....tkrdsdyinacfvdgyar.kncyiaaqg
subfamily_eak_pd Subfamily eak 7-236 1.2e-13 45.2 In-house 58-307 (332) alignment 
Range on Protein: 7-236
Range on HMM: 58-307/332.0
ANIIAYDHSRVILEPDSAgdKICDYINASyLHGFDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVSR---EYGDITV
 .|. ||.  | | .         ||||| |  |    . || |  .       ||.|. ..||  ||.| .  | .  |  .|.|| .|   ..| . |
vkivpydrylvrltssql..nrlGyinas.laefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildv

SVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHftVWPDKGVPQHA---------------------TAVLGFRKKVNANNPYGSGPIvVHCSAGVGRTG
   .    . .  | | | |  |. . .  ...   | .  .|.                       .|.|    |     |    || . .. |  |.|
erkefvkrniletrllelskGnethrvlhykvf..GwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapi.iqsarGsaraG

AYIAIDAMLNQAHREK--KVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVC
... || ...     |     . ...  ..  ||| | .. |. |.. ..|.    
vfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllr
0044763 (Phosphotyrosine protein) phosphatases II 12-230 1.8e-32 107.8 In-house 2-167 (178) alignment 
Range on Protein: 12-230
Range on HMM: 2-167/178.0
YDHSRVILEPDsAGDKICDYINASYLHGFdgsfkAYIATQGPvvasfVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVSReygditvsvhstevf
.|..||.|..   |   .||||||.  ..      |.....|     .|.........  .||.||. .|  ..||..|||.                  
ldrtrvllsnl.eglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

adytkrvlflakrseadkrhvVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQahrekKVDIYKYVEMMRR
                     .| ... .|| |||.    .| | . ...  .   ||..|||||||||.|. .|.. |. .     ...... .|..|.
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvre

DRIhMVQTEEQYIFVHMAI
 |  .|....|. ....  
rRp.ivpnpgqlrqLyefe
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 15-231 3.1e-17 57.6 In-house 33-256 (290) alignment 
Range on Protein: 15-231
Range on HMM: 33-256/290.0
SRVILEpdSAGDKIC-DYINASYLHGFDGsfKAYIATQGPVVAS-------FVDFWRMIWQEKSAVIVMLTNLKESEKV----KCHQYWPDVSR---EYG
.||.|.    | ..  ||| |...   .|   . |.|| |  .          .|| |. |||.  .||| . .| ..      | .| |.       ..
trvvLk..gygkrfnddyiHAnrvtcpng..lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfk

DITVSVHSTEVFADYTKRVLFLaKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNpygsGPIVVHCSAGVGRTGAYIAIDAMLNQ-AHREK
..||.  | |   |  .| | . |  .  .  |    .  | .  |...   .|   .||.|..     |..|||  |. |  |  ||.      |. ..
gltvkCkskekeddvetRelvv.kfddeeeftvtHsllkgWnklnvqedtktllsliqkvkask....tpvivHcvdGiSrsAalaaiilgyQkiaetsg

KVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAIL
.| . . ....|. | ......... ||  .|.
svkledvlkalrkqralaitsalelafvdagiv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 25-228 9.6e-29 95.1 In-house 73-275 (301) alignment 
Range on Protein: 25-228
Range on HMM: 73-275/301.0
GDKICdyINASYLHGFdGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVSREYGDI---TVSVHSTEVF--ADYTKRVL
| ..   | | ..    |  . .||||||. ..  ||| |. | .   ||||..  | .. ||..| |   .|  ||   .. ....|.    . .|| |
GkrvP..ihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtl

FLAKRS-EADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNpygsGPIVVHCSAGVGRTGAYIAIDAMLNQAHREKKVDIYKYVEMMRRDRIHMVQ
 ..  . . . | |.   .. |.|.|||.  . .  . . |   .     |||||||||.||. |.|. . . .. . ...... . .. .| .| . ||
evedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvq

TEEQYIFVHM
|..|  .. .
tnsqlywmtl
0043147 (Phosphotyrosine protein) phosphatases II 26-227 3.7e-40 132.8 In-house 2-154 (172) alignment 
Range on Protein: 26-227
Range on HMM: 2-154/172.0
DKICDYINASYLHGFDGSFKaYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLkesekvkchqywpdvsreygditvsvhstevfadytkrvlflAKRS
|. .||||||||..     . .||||||    . |||||.....  .||.||.|                                           .  
degsdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel..........................................lydp

EADKRHVVQLHFTVWPDKGVPqHATAVLGFRKKVNA-NNPYGSGPIVVHCSAGVGRTGAYIAIDAMLnqahreKKVDIYKYVEMMRRDRIHMVQTEEQYI
|  .|...|.... ||| ||| ..  .| | . ..   . . .||..|||||||||||. .|.. ||      ....... |...|. | ..||...||.
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyr

FVH
|..
fly
0046846 (Phosphotyrosine protein) phosphatases II 27-231 3.5e-42 139.5 In-house 10-170 (176) alignment 
Range on Protein: 27-231
Range on HMM: 10-170/176.0
KICDYINASYLHGFdgsfkAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVSREYGditvsvhstevfadytkrvlflakrse
  .|||||... |      ..||||||.. .. ||..|.....  ..|.||...| ...||..|||.. ..                             
ldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

adkrhvvQLHFTVWPDKGVPQHaTAVLGFRKKVNANNPYGsGPIVVHCSAGVGRTGAYIAIDAMLNqahrEKKVDIYKYVEMMRRDRI-HMVQTEEQYIF
       | ... ||| |||.. ...| . . ..     | ||..||||||.||||...|.. .      || ..... ....|. |  ..|||.||| |
.......qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyrf

VHMAIL
.....|
lyefel
0051429 (Phosphotyrosine protein) phosphatases II 29-242 5.2e-54 179.0 In-house 4-232 (272) alignment 
Range on Protein: 29-242
Range on HMM: 4-232/272.0
CDYINASYLHGFdGS---FKAYIATQGPVVASFVDFWRMiWQEKSAVIVMLTNLKESEKVKCHQYWP-------------DVSREYGDITVSVHSTEVFA
 .||||... |. |.    .......||  ..  ||||. ....  .||.|... | ...||..|||             . . .||...| ..|.|.. 
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DYTKRVLFLAKR-SEADKRHVVQLHFTVWPDKGVPQHAtaVLGFRKKVNAnnpygSGPIVVHCSAGVGRTGAYIAIDAMLNQAHREKKVD--------IY
||. |.| | .  |  . |.| .||.| ||| ||||.|  .| . . ...     .||..||||||..||| ..|.. .| . ..|  ||        ..
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

KYVEMMRRDRIHMVQTEEQYIFVHMAILEAtVCGNTEVP
..||..|. | ..|||||||.|...|.||. ... ..|.
eaveelraqrpgavqteeqylflyeallel.lrsllsvr
0051082 (Phosphotyrosine protein) phosphatases II 29-231 2.6e-36 119.8 In-house 3-150 (151) alignment 
Range on Protein: 29-231
Range on HMM: 3-150/151.0
CDYINASYLHGFdgsfkaYIATQGPvVAsfvDFWRMIWQEKSAVIVMLTNLKESEkvKCHQYWPDVSreygditvsvhstevfadytkrvlflakrsead
 ||||.||. |.      .....||  |   ||........  .||.|....| .  .|..|.|. .                                 
sdyinfsyvtgg......lyrsggp.la...dflellkelgiktivnlrseeerg..ycpeylpelg.................................

kRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNAnnpYGSGPIVVHCSAGVGRTGAYIAIDAMLNQahrekkVDIYKYVEMMRRDRIHMVQTEEQYIFVHM
 ..|...... ||| |.|..  ||| | .....    ..||..||||||.||||. .|.. || .      |.... .|..|. | ..||...|..|...
.ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

AIL
|.|
all
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 29-144 1.8e-08 28.8 In-house 13-125 (130) alignment 
Range on Protein: 29-144
Range on HMM: 13-125/130.0
CDYINASYLhGFDGSFKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEkvkchQYWPDVSR-E--YGDITVSVHSTEVFADYTKRvlFLAKRS
 .|||||.. |  |  . |. || |. .. .|||.|. .    |.|.|  ..| .     .||||    |    ||.|..   . |        .|   |
ntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePlewyeediivtltdrdefknikas..nleies

EADK--RHVVQLHFTVWPDKG
.  .  . .  .. . ||  |
dlneshqaltmfqisnwpsdg
0036282 (Phosphotyrosine protein) phosphatases II 30-227 4.4e-45 148.8 In-house 3-163 (174) alignment 
Range on Protein: 30-227
Range on HMM: 3-163/174.0
DYINASYLHGFDGSFkAYIATQGPVVasfvdFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDvsreygditvsvhstevfadytkrvlflakRSEADK
||||||.|...  .   .||.|||       ||.|...... ..|||...|| ...||..|||.                              ..|  .
dyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredle

RHVVQLHFTVWPDKGVPQHATaVLGFRKKVNANNPY-GSGPIVVHCSAGVGRTGAYIAIDAMLNQAHrEKKVDIYKYVEMMRRDRIHMVQTEEQYIFVH
|...|.... ||| |||  .. .| | | |.      ..||..|||||||||||. .|.. || . . |. ||....| ..|. | .||||..||.|..
rlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
0049260 (Phosphotyrosine protein) phosphatases II 44-227 3.6e-39 129.2 In-house 8-143 (152) alignment 
Range on Protein: 44-227
Range on HMM: 8-143/152.0
FKAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWpdvsreygditvsvhstevfadytkrvlflakrseadkrhvvQLHFTVWPDK
 ...||||||   .. |||||... .  .|||||.| |  |.||.||.                                          | ... ||| 
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDh

GVPQHATAVLGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLnqahreKKVDIYKYVEMMRRDRIHMVQTEEQYIFVH
|||...  .| . . ..  . . .||..|||||||||||...|.. ||      ..|.....|...|. | ..|....|..|..
gvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 45-227 2.8e-23 77.1 In-house 5-197 (199) alignment 
Range on Protein: 45-227
Range on HMM: 5-197/199.0
KAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVS---REYGDITVSVHSTEVFADYTKRVLFLAKRSEA--DKRHVVQLHFTV
. ||||| |.  .. |||.|.|.  |  |||. . .   ..    ||| .     .|| ..|....  . .|||  .| |.. . |    | . .  || 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPQHATAV---LGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLnQAHREKK---VDIYKYVEMMRRDRIHMVQTEEQYIFVH
| .|  |. |  |   .  |.  .  .     |..|||| | | || ..|.|  . ..| | |   ||...    .|. |  .. . ..| |..
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigv.rsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 45-227 3e-23 77.1 In-house 4-196 (198) alignment 
Range on Protein: 45-227
Range on HMM: 4-196/198.0
KAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVS---REYGDITVSVHSTEVFADYTKRVLFLAKRSEA--DKRHVVQLHFTV
. ||||| |.  .. |||.|.|.  |  |||. . .   ..    ||| .     .|| ..|....  . .|||  .| |.. . |    | . .  || 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPQHATAV---LGFRKKVNANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLnQAHREKK---VDIYKYVEMMRRDRIHMVQTEEQYIFVH
| .|  |. |  |   .  |.  .  .     |..|||| | | || ..|.|  . ..| | |   ||...    .|. |  .. . ..| |..
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigv.rsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 45-122 1.2e-08 28.7 In-house 236-312 (440) alignment 
Range on Protein: 45-122
Range on HMM: 236-312/440.0
KAYIATQGPVVASFVDFWRMIWQEKSAVIVMLTNLKESekvKCHQYWPDVSR--EYGDITVSVHSTEVFADYTKRVLFLA
.|.|||| |. .. .||||.. . . . |.|| .|..     |  |||  .|   .| .||  . .| .     | | | 
nafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelk
subfamily_hpo-7_pd Subfamily hpo-7 55-233 4.9e-17 56.7 In-house 44-226 (263) alignment 
Range on Protein: 55-233
Range on HMM: 44-226/263.0
VASFVDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWP---DVSREYGDITvsVHSTEVFADYTKRVLFLAKRSE-ADKRH-VVQLHFTVWPDKGVPQHA
|     |...| | |. |.|||.. .| ...|| .|.|   |  . . ...  | .|.|  |  .. | | .  .   | | | .  .. |..|  |. |
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvn..vcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpela

TAVLGFRKkVNANnpygSGPIVVHCSAGVGRTGAYIAIDAMLN------QAHREKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEA
  .|   | |. |    | ..|||||.|.||. |.  .. .        .     ..|  . .| .|  |   ..|  |  |  . .|. 
reilnilk.varn....skslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdf
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 59-233 8e-23 75.3 In-house 105-287 (302) alignment 
Range on Protein: 59-233
Range on HMM: 105-287/302.0
VDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPDVS------REYGDITVSVHS-TEVFADYTKRVLFL-----AKRSEADKRHVVQLHFTVWPDKGVP
  .| .| | . |..| |....|.|. || .|. |        ..|   ||||.   | |.|  . .|.       |. .. |. |  |.|. |||.| |
ekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGap

QHATAVLGFRKKVNAnnpYGSgPIVVHCSAGVGRTGAYIAIDAMLNQAHREKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEA
..| . |   |  ..   |    ..|||||||||||. .||   ..   ..|  |. . |  .|. |   ||.|.| |.. . .  .
keaytaldilkfces...ykk.nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkg
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 59-234 1.1e-18 62.2 In-house 42-221 (255) alignment 
Range on Protein: 59-234
Range on HMM: 42-221/255.0
VDFWRMIWQEKSAVIVMLTNLKESEKVKCHQYWPD---VSREYGDITvsVHSTEVFADYTKRVLFLAKR-SEADKRHVVQ-LHFTVWPDKGVPQHATAVL
  |...| | |. |.|||....| ...||..|.|      . . |..  | .|.  ||   | | .    .|  | | |.  ... |..|  |. |  .|
dkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvn..vtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

GFRKKVNAnnpygSGPIVVHCSAGVGRTGAYIAIDAMLN------QAHREKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEAT
   | |       | ..|||||.|.||. |.. .. .        .     ..|  . .| .|  |   ..|  |  |  . .|.  
nilkvvrd.....sksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
0048076 (Phosphotyrosine protein) phosphatases II 98-231 3.3e-26 87.1 In-house 13-140 (145) alignment 
Range on Protein: 98-231
Range on HMM: 13-140/145.0
YGDITVSVHSTEVFADYTKRVLFLAKRSEADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYGsGPIVVHCSAGVGRTGAYIAIDAMLNqahre
.|.... ..  .      ..|| |.   |  .|...|.... ||| |||. .  .| | . ...  . | ||..|||||||||||...|.. ||      
lgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....

KKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAIL
..|.... .|..|. | ..|....|..|.....|
lgvsleealelvrsqrpgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 126-228 5.5e-25 83.2 In-house 43-139 (144) alignment 
Range on Protein: 126-228
Range on HMM: 43-139/144.0
EADKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPyGSGPIVVHCSAGVGRTGAYIAIDAMLnqahrEKKVDIYKYVEMMRRDRIHMVQTEEQYIF
|  .|...|.... ||| |||.... .| | . ...  .  .||..|||||||||||...|.. |.     ........ ....|. | ..|....|..|
efleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrf

VHM
...
Lle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 128-261 3.8e-33 109.5 In-house 87-221 (440) alignment 
Range on Protein: 128-261
Range on HMM: 87-221/440.0
DKRHVVQLHFTVWPDKGVPQHATAVLGFRKKVNAN-NPYGSGPIVVHCSAGVGRTGAYIAIDAMLNQAHREKKVDIYKYVEMMRRDRIHMVQTEEQYIFV
. | . | |.  |||||||. |  || . . || . .  |.||..||||||.||||  ||.|..| .|.|  ..||. ... || .| .|||| ||| ||
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HMAILEATVCGNTEVPVQDLSRTITKLSAVVPGKG
| |.||. .||.| .  .|..  . ..    |   
heavlegllcgdtliledditerveqiqwpnphtd
subfamily_PTPDC1_pd Subfamily PTPDC1 130-227 5e-08 27.6 In-house 80-169 (182) alignment 
Range on Protein: 130-227
Range on HMM: 80-169/182.0
RHVVQLHFTVWPDKGVPQHaTAVLGFRKKVNANnpYGSGPIVVHCSAGVGRTGAYIAIDAMLNqahreKKVDIYKYVEMMRRDRIHMVQTEEQYIFVH
.. .  .   |.| ||.   . .|   | |.       | . ||| || ||||  ||   . .     |...  | ....|  | . .|| ||  .|.
eqgiyvynfgwkDygvasl.eriLdivkvvafa..lqegkvavhChaGlGrtGvliacylvya.....krltaekaiklvrskrpksiqtreqvelvk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 131-231 2.3e-15 51.2 In-house 216-341 (350) alignment 
Range on Protein: 131-231
Range on HMM: 216-341/350.0
HVVQLHFTVWPDKGV---PQHATAVLGFRK----KVNANNPY---GSGPIVVHCSAGVGRTGAYIAIDAMLN-------QAHREKKVD--------IYKY
 | ||..  |.| ..   |.    .|  ..    . .|.. .    | ||.||||||||||| ....| .|.         .. .|.|        |   
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VEMMRRDRIHMVQTEEQYIFVHMAIL
|  .|. || |||. .|.||.. |.|
vnelrkqrismvqnldqfifiYeall
0038934 (Phosphotyrosine protein) phosphatases II 131-222 6.2e-08 28.0 In-house 78-168 (194) alignment 
Range on Protein: 131-222
Range on HMM: 78-168/194.0
HVVQLHFTVWPDKGVPQHATAVLGFRKKV-NANNPYGSGPIVVHCSAGVGRTGAYIAIDAMLNqaHREKKVDIYKYVEMMRRDRIHMVQTEEQ
. .. .   .||.|..     .| | . |   .|   .| ..||| ||.||||  .|   .    .. .  . .......|.. |  ..  |.
agieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr..lgmsaeeAialfrekRpgaipnqdylea
PTPc_DSPc_SM00012 132-232 7.3e-36 117.9 In-house 2-105 (105) alignment 
Range on Protein: 132-232
Range on HMM: 2-105/105.0
VVQLHFTVWPDKGVPQHATAVLGFRKKVNANNPYG--SGPIVVHCSAGVGRTGAYIAIDAMLNQAHRE-KKVDIYKYVEMMRRDRIHMVQTEEQYIFVHM
| ..|.| |||.|||......| . ..|. |.     |.|.|||||||||||| ..|.| .|.| ..| |.|||...|...|. | .||||||||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AILE
|.||
alle
0048567 (Phosphotyrosine protein) phosphatases II 135-217 1.9e-06 22.3 In-house 40-125 (157) alignment 
Range on Protein: 135-217
Range on HMM: 40-125/157.0
LHFTVWPDKGvPQHATAVLGFRKKVNANN---PYGSGPIVVHCSAGV---GRTGAYIAIDAMLNQAHreKKVDIYKYVEMMRRDRIHMV
.... . | | | . . .  | .|.|       . ...|.|||.||    |||.  |.  ..| .       ...... ..| . ..  
vyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgf..tpeeaiaplrivrpgsvpfr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 166-231 1e-10 35.5 In-house 264-341 (349) alignment 
Range on Protein: 166-231
Range on HMM: 264-341/349.0
GSGPIVVHCSAGVGRTGAYIAIDAMLN-----QAHR------EKKVD-IYKYVEMMRRDRIHMVQTEEQYIFVHMAIL
 . ...|||||| |||| .. .| .|.     | .        .. | |.  |  .|. || |||   |.|... |.|
qlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealL
subfamily_CG42327_pd Subfamily CG42327 167-229 1.9e-16 54.6 In-house 247-310 (319) alignment 
Range on Protein: 167-229
Range on HMM: 247-310/319.0
SGPIVVHCSAGVGRTGAYIAIDAMLNQAHRE-KKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMA
 ||.||||| ||||||  || |  ...     . ||| . |  .|||| . |.| ||| |..  
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_CDC14_pd Subfamily CDC14 167-214 5.9e-06 20.4 In-house 263-308 (328) alignment 
Range on Protein: 167-214
Range on HMM: 263-308/328.0
SGPIVVHCSAGVGRTGAYIAIDAMlnQAHREKKVDIYKYVEMMRRDRI
.| |.||| ||.||||. ||   |  . .|    ..  .. ..|   .
eGaiavhCkaGLGrtGtLiacylm..khyrftaaeaiawlricrPGsv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 168-232 1.7e-13 45.1 In-house 229-293 (297) alignment 
Range on Protein: 168-232
Range on HMM: 229-293/297.0
GPIVVHCSAGVGRTGAYIAIDAMLNQAHREKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILE
 ...|||||||||.|  .  |..|..  ...  |.   ....|  |  .||| ||. ... |.|.
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 170-235 3.2e-18 59.9 In-house 1-66 (69) alignment 
Range on Protein: 170-235
Range on HMM: 1-66/69.0
IVVHCSAGVGRTGAYIAIDAMLNQAHREKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATV
.|||||.| ||||..|||   . .   || |||.  |  ||. |  ||  | .|||.| |. ||  
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 171-237 1.3e-17 57.9 In-house 1-67 (69) alignment 
Range on Protein: 171-237
Range on HMM: 1-67/69.0
VVHCSAGVGRTGAYIAIDAMLNQAHREKKVDIYKYVEMMRRDRIHMVQTEEQYIFVHMAILEATVCG
|||||.| ||||..|||   . .   || |||.  |. ||. |  ||  |..|.|.| |. ||   |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 237-532 1.3e-120 397.1 In-house 1-297 (298) alignment 
Range on Protein: 237-532
Range on HMM: 1-297/298.0
GNTEVPVQDLSRTITKLSAVVPGKGITGFADEFQRLRLVSDSIKEDETNVAKNLQNQNKNRDMEYLPceLNSSRVVLFS--TKKEADYINASFADAYKER
||||. ..||.....||.|| . |..||.|.|||||. ||..|.|.|..||.. .|..||| .....  |.|||||| .  ...|.|||||||..|||.|
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiia..ldssRvvLekedadeesdYiNAsflhaykgr

DLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQ-TYTEYWPTEHPEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQSHVIVRHFSYFNWPDK
. ||.||||.|.|...|||||.....||||||..|||... .|..|||.|. | ||.. |. ||.....|...|.||||...|...  ||......||||
nafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdk

SGPANYQSALELMSEVQRSQQQAKNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLDTFGDYA
. |.|..| |.|...|..|||||.|.|.|||||.|..|||.|.||.|.|||.|.|||||||||.||.|.|||..|.. .||| .||. |..||.| |..
gvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0051299 (Phosphotyrosine protein) phosphatases II 237-525 2e-74 246.0 In-house 1-286 (288) alignment 
Range on Protein: 237-525
Range on HMM: 1-286/288.0
GNTEVPVQDLSRTITKLSavvpGKGITGFADEFQRLRLVSDSikeDETNVAKNLQNQNKNRDMEYLPCElnSSRVVLFSTKK--EADYINASFADAYKER
|.||..|..| ... ||      .|.||...||..|. .  .    ....|.  .|..||| . .||..  .|||.| ....  . ||||||. | |.  
gdteisveellklvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpyd..hsRVkLsvldgvegsdYinAsyidgynlk

DLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETG-QTYTEYWPTEHPEIYGSVLVEPLSNDNYGDFTMRRLKVSSY----TEQSHVIVRHFSYFN
  ||.||.|. .|. .|||||....  .||||..|.| | ...  |||......|| . |. || . ..|.|.| |.|. .     .. . .|.|| |.|
rkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytn

WPDKSGPANYQSALELMSEVQRSQQqAKNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYL
||| . | . .. |... .|..... ... |..| ||.|  |.|.|.|.. .||.|. |..|||....| .| .||..|... ||. .||..| ||
wpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPRG_pd Subfamily PTPRG 241-522 2.3e-56 186.2 In-house 1-284 (563) alignment 
Range on Protein: 241-522
Range on HMM: 1-284/563.0
VPVQDLSRTITKLSAvvpgKGITGFADEFQRLRLVSDSiKEDETNVAKNLQNQNKNRDMEYLPCElnSSRVVLFST---KKEADYINASFADAYKERDLF
|||..... ...| |    .| .||. ||. |   . | |. ... ... .|..|||... .. .  .||| | ..   ||. |||||.. | |.  . |
vpvkefakhvaslha....dgdigfseefealqsetis.kdldaehsqkpenkrKnRylnivayd..rsRvklsplpgkkkklDYinAnyidGyqkskaf

IMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQT-YTEYWPTEHPEIYGSVLVEPLSNDNYGDFTMRRLKVSS-----YTE-QSHVIVRHFSYFNW
|.|| |...|.  ||||. . .. .|||.  |.| |.     |||....| ||.. |   ...     |.|.|..         . ...  ||.. | .|
iatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkW

PDKSGPANYQSALELMSEVQRSQqQAKNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMAL
||.. |      |  .   .... .|.  ||.| ||.|..|.| .... ..|.... |..|.||...| || .|.  |..  ||.  ..  |
PdhgvPehslpvLifvkkssaan.kaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdall
subfamily_PTPN9_pd Subfamily PTPN9 249-524 4.8e-48 158.7 In-house 2-289 (297) alignment 
Range on Protein: 249-524
Range on HMM: 2-289/297.0
TITKLSAVVPGKGITGFADEFQRLRLVSDsikEDETNVAKNLQNQNKNRDMEYLpCeLNSSRVVLFST--KKEADYINASFADAYKERDLFIMTQAPMTQ
.|..| | |  ||. |   |.. .|  .    | . ...|   | .|||  . | | ....|||| ..  ....|||||.| | ||... || || |. .
eieelvayvkekgkrGlskeyaeirnepv...eGtflasklranleknrytdvl.c.ydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkk

TTVEFWRMVMQYKAGTIVMLNTLEETGQT-YTEYWPTE--HPEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSAL
|. .||||| . .. .|||   ..|.|.   ..|||.|  . . .|.. |. .. ... |...| |...  ... .  | || .  |||   | . .| |
tvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaasll

ELMSEVQRSQQQ------------AKNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRY
.....|.. | .            ... ||.| || |  |.|.|...   |.||. ...|||....| .| .|  |.    ||. ||   | |
dvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 250-534 1.2e-61 203.3 In-house 7-287 (287) alignment 
Range on Protein: 250-534
Range on HMM: 7-287/287.0
ITKLSAVVPGKGITGFADEFQRLRLVSDSIKEDETNVAKnlQNQNKNRDMEYLPCelNSSRVVLFstKKEADYINASFADAYKERDLFIMTQAPMTQTTV
. ...|  . || .|| . |. |  |... .|   |.|.  ||..|||  . |.   .  ||.|   ... |||||.| |.|||.  ||....||..| .
fgefvakghakgnegfknqftvleqvtqredevthnias..qnkdknRltqilvp..dnyrvllk..gehpdyinavfidgykekkafiiaesPmfntar

EFWRMVMQYKAGTIVMLNTLEETGQT-YTEYWPTEHPEIYGSVLVEPLSNDNYGDFTMRRLKVSSYT-EQSHVIVRHFSYFNWPDKSGPANYQSALELMS
.||... . .  .||||  ..|. .    .|||.|.  ..|   .| |... . ....|.|.|   . ....  |. . . ||...   ...|. | .. 
nfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvie

EVQRSQQQAKNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLDTFGDYANF
|  ..|..  | .|.| ||..  ||. |||.   ... | | |.|||||.|  ||..|.||   .||   ... | |||.|  |..|
emyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_PTPN6_pd Subfamily PTPN6 250-527 4.2e-47 155.6 In-house 13-299 (306) alignment 
Range on Protein: 250-527
Range on HMM: 13-299/306.0
ITKLSAVVPGKGITGFADEFQRLRLVSDSiKEDETNVAKNLQNQNKNRDMEYLPCelNSSRVVLF-STKKEADYINASFAD--AYKERDLFIMTQAPMTQ
...|.     .. .|| .||..|.    . |  . . ..  .|..|||    ||   . .||.|  .  ...|||||.. .  . ...  .| ||  ...
vselekeeeslekagfeeefeelqqeeak.kllsrkegakpenkeknryknilPf..Dhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclet

TTVEFWRMVMQYKAGTIVMLNTLEETGQ-TYTEYWPTE-HPEIYGSVLVEPLSNDNYGDFTMRRLKVSS-YTEQSHVIVRHFSYFNWPDKSGPANYQSAL
|  .|||||.| ..  |||. .  | |.   . |||.| . | ||.. |. .|...  |...|.|.||   .....  |... . .|||.. |.. .  |
tvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavL

ELMSEVQRSQQQAK---NRPIIVQCSNGTTRSGAFCAIYSILERLK---IEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLDT
.....|.| |.. .   ..||.| ||.|  | |.|  |  .|. ..   ..  .|. ...|..|  | . |   .||   |..   |..|
dfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 252-525 8.2e-26 85.4 In-house 11-287 (305) alignment 
Range on Protein: 252-525
Range on HMM: 11-287/305.0
KLSAVVPGKGITGFADEFQRLRLVSDSikeDETNVAKNLQNQNKNRDMEyLPCeLNSSRVVLfSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEF
|.   .  || .|.  ||. .. . |    .  .  |. |...|||  . . | |.  || |  .    .|| | .  .  .   || ||||. .|  .|
kfvkrtlekgpaglraefvamkrfndf...ekmkafkeaqeagknrykd.vgc.ldnnrvkl.egpwpheyihanyvstptnpkrfictqaplektcadf

WRMVMQYKAGTIVMLNTLEETG-QTYTEYWPTEHPEIY------G--SVLVEP-----LSNDNYGDFTMRRLKVSSYTEQsHVIVRHFSYFNWPDKSGPA
| | .| |  .| ||  | | | .  .||..... ..          || .|      . .|   . |   | .    |.    | |. . .|||.  ||
wymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgek.arkvthyhwidwpdrgvpa

NYQSALELMSEVQRSqqqakNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVV-DVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYL
  .. |||. . . |       ||.| || |  |.|.   .  ||..|   |.. |  .... || .| .|. . |||.  ... | |.
adlailellekarps.....kgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
0050432 (Phosphotyrosine protein) phosphatases II 253-531 2.4e-75 249.1 In-house 32-305 (308) alignment 
Range on Protein: 253-531
Range on HMM: 32-305/308.0
LSAVVPGKGITGFADEFQRLRLVSDsikEDETNVAKNLQNQNKNRDMEYLPCElnSSRVVLfstKKEADYINASFADAY--KERDLFIMTQAPMTQTTVE
| .. . ......  ||..|. | .     |..||.  .|..||| . .||..  .|||.|   ... ||||||. | |  | .  ||.||.|. .|.  
lkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpyd..hsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpntved

FWRMVMQYKAGTIVMLNTLEETG-QTYTEYWPTE---HPEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELM
|||||....  .||||..|.| | ... .|||.|   ....|| . |. || ....|.|.| |... . ..   .|.|| | |||| . | . .. |...
FwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldfl

SEVQRSQqqaKNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLDTFGDY
 .|..|.   .. ||.| ||.|  |.|.|.|.. .||.|. |. ||||...| .| .||..|... ||. .|...| || ..  .
elvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk
0039614 (Phosphotyrosine protein) phosphatases II 254-528 2.9e-69 229.1 In-house 23-292 (297) alignment 
Range on Protein: 254-528
Range on HMM: 23-292/297.0
SAVVPGKGITGFADEFQRLRLVSDsikeDeTNVAKNLQNQNKNRDMEYLPCelNSSRVVLFSTKKE---ADYINASFADAYKE-RDLFIMTQAPMTQTTV
  . . ...|..  ||..|  . .    | . .|.  .|..||| ...||.  ..|||.| . ..     ||||||. | |.   . ||.||.|...|. 
lllekansktllllefeellslkp....d.ysiallpenkdknrykdilpy..dhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetve

EFWRMVMQYKAGTIVMLNTLEETGQTYTEYWPTEHPeIYGSVLVEPLSNDNYGDFTMRRLKVSSyTEQShVIVRHFSYFNWPDKSGPANYQSALELMSEV
 ||||| ...  .||||..|.| |... .|||.|    || . |. |. . ....|.| |.|.  ...|  .|.|| |..||| . | . .. ||.. .|
dFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn.nges.rtvthfqytgwpdhgvppslellleflelv

QRSQQQA-KNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLDTF
.. .... |..|..| ||.|  |.|.|.|.| .||.|. |. |||....| .| .||..|... ||. .|...| .| ..
realaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 257-527 2.8e-30 100.0 In-house 21-285 (290) alignment 
Range on Protein: 257-527
Range on HMM: 21-285/290.0
VPGKGITGFADEFQRLRLVSDSIKEDETNVAKNLQNQNKNRDMEyLPCElNSSRVVLfSTKKEADYINASFADAYKerDLFIMTQAPMTQTTVEFWRMVM
|  |.. ..| |.          .  | ..  .  . .|||  . ..|. . .||.| .   . ||. | . .  |    ||.|| ....|....||||.
vvkknvdelakeyleklkpylpvqylerkifdkntefkknrykd.vvcn.dktrvil.kdGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvl

QYKAGTIVMLNTLEETGQTY-TEYWPTEHPEI--YGSVLVE-PLSNDNYGDFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQrs
| |. .||||  | | |..   .|.| .. |.  .|.. |   ...|.  .  .. | |    .  . ...|.    ||||| .    . | ..  ..  
qekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilr..

qqQaKNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLDT
  .  . |..| || |  |.|.| ||   |. |   . .|. .... .|  | .||    ||.   |. | .   
..k.asGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkd
0045450 (Phosphotyrosine protein) phosphatases II 258-525 4.1e-65 215.8 In-house 22-304 (307) alignment 
Range on Protein: 258-525
Range on HMM: 22-304/307.0
PGKGITGFADEFQRLRLVSDSIkEDETNVAKNLQNQNKNRDMEYLPCElnSSRVVLFSTKK---EADYINASFA--------DAYKERDLFIMTQAPMTQ
. ...||.. ||..|. | . .  .|...|. ..|..||| ...||..  ..||.| |...   . ||||||.         | |.  . ||.||.|. .
lldfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpyd..htRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

TTVEFWRMVMQYKAGTIVMLNTLEETGQT-YTEYWPTE-HPEIYGSVLVEPLSNDNYGDFTMRRLKVSSY-TEQSHVIVRHFSYFNWPDKSGPANYQSAL
|  .||||. ... ..||||..|.| |.  . .|||.| ..  || . |. || . ....|.|.|.|. .  .. . .|.|| | .||| . | . ...|
tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeell

ELMSEVQRSQQQA-KNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQV---VDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYL
... ||.. ...  |. |..| || |  |.|.|.|.| .|..|. |..   ||.....| .| .||..|... ||. .||..| .|
dfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 258-531 4.4e-62 204.6 In-house 15-289 (290) alignment 
Range on Protein: 258-531
Range on HMM: 15-289/290.0
PGKGITGFADEFQRLRLvsdSIKEDETNVAKNLQNQNKNRDMEYLPCelNSSRVVLFSTKKEAD----YINASFADAYKERDLFIMTQAPMTQTTVEFWR
  || .|| ..|..|     . .| ...|.   .|...||  ....   .  |..|    .. |    ||||.. . |||.  .|.||.|...| |.||.
hakgnegfrnqfkmlds...gesehtvtvgltssnkllnRfanivvy..ddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWk

MVMQYKAGTIVMLNTLEETGQ-TYTEYWPTEHPEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTE-QSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQR
...| |   |||| .  | |. .   |||..  . || . .. |.. .. ... |.|.| . .. ... .| ..   ||...   .|.|. | ...|...
liwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk

SQQQAKNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLDTFGDY
 | .  |..|.| ||.. .||. |||..  ... |.|.|.|||||.|  ||..|.||..  ||   ... |.|||.|  |
tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
0047943 (Phosphotyrosine protein) phosphatases II 260-525 1.6e-69 229.8 In-house 9-272 (273) alignment 
Range on Protein: 260-525
Range on HMM: 9-272/273.0
KGITGFADEFQRLRLVSDsikEDETNVAKNLQNQNKNRDMEYLPCelNSSRVVLfsTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYK
.|.|... ||..|. . .   . ...||.  .|..||| . .||.  ..|||.|  . .. ||||||. | |.    ||.||.|. .|. .|||||....
lgltllleefelllslkp...lltysvallpenkdknrykdilpy..dhsrvkl..gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

AGTIVMLNTLEETGQ-TYTEYWPTEH---PEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQ
. .||||..|.| |. ..  |||.|    ...|| . |. || ....|.|.| |.....  .   .|.|| |..||| . |....| ||.. .|.. ...
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

A-KNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYL
. .| |..| ||.|  |.|.|.|.. .|..|. |. |||....| .| .|| .|... ||. .||..| ||
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0043336 (Phosphotyrosine protein) phosphatases II 260-525 1.3e-66 220.3 In-house 17-277 (278) alignment 
Range on Protein: 260-525
Range on HMM: 17-277/278.0
KGITGFADEFQRLRLVSDsikeDETNVAKNLQNQNKNRDMEYLPCELNSSRVVLFSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYK
.. |..  ||..|. .      |....|. ..|..||| . .||.. .  .. |..     ||||||. | |.  . ||.||.|...|.  ||||| ...
nlktllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelg

AGTIVMLNTLEETG-QTYTEYWPtEHPEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQqAKN
  |||||..|.| | ... .||| .... || . |. |. . ..|.|.| |.|. . .    .|.|. |..||| . | . .. |... .|.. ..  .|
vttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsn

RPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYL
 |..| ||.|  |.|.|.|.| .||.|. |. ||.....| .| .||..|... ||. .||..| ||
gpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 260-523 3.5e-60 198.5 In-house 18-277 (288) alignment 
Range on Protein: 260-523
Range on HMM: 18-277/288.0
KGITGFADEFQRLrlvSDSIKEDETNVAKNLQNQNKNRDMEYLPCELNSSRVVLFSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYK
.. ||| .|.. |   .   |......... .|..|||  . || . .  ..    ....|||||||. | .|..  .| ||.|...|  .||..| ..|
rnrtgfseeynsL...aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenk

AGTIVMLNTL-EETGQTYTEYWPTE-HPEIYGSVLVEPLSNDNYGDFTMRRLKVSsyTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQAk
. |||||. | |.  ..  ||||.. .|. |||| |. ... . .||..|.| .    ..... . .. |  |||.. |.. .  |||.. |. ..|.  
tstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.

NRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALR
  ||||.||.|  |.| | |.  ...... |...||. ... .| .|.. |  | ||. .||. | 
tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_PTPN23_pd Subfamily PTPN23 260-525 1.3e-48 160.3 In-house 12-280 (288) alignment 
Range on Protein: 260-525
Range on HMM: 12-280/288.0
KGITGFADEFQRLRLVSDSIkEDETNVAKNLQNQNKNRDMEYLPCElnSSRVVLFstKKEADYINASFADA-YKERDLFIMTQAPMTQTTVEFWRMVMQY
.| |..  .|. |.   |     .. .|    . .|||  . || .  ..||.|   ... |||||||          ||.||||. .|  .||.||.. 
dgktaldkkfkeleqkqdke.arkrsiaiaklyseknrsrdilPyD..hnRvklr..gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeq

KAGTIVMLNTLEETGQT-YTEYWPTE--HPEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQR---S
|. .|||| . ||.|..   .|||..  ... .| . |   |. . . .  | ||..   ..    |.|  ...||.   ||  .. |... ||.    .
kssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayea

QQQAKNRPIIVQCSNGTTRSGAFCAIYSILERLKIE-QVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYL
.|.  . |..|.|| |  |.|.|. .|.... |. .  ..|. ||.. .| .|  .|   .|.  .||. |.. 
vqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 260-525 1.1e-29 98.5 In-house 13-277 (307) alignment 
Range on Protein: 260-525
Range on HMM: 13-277/307.0
KGITGFADEFQRLrlvSDSIKEdETNVAKNLQNQNKNRDMEyLPCElNSSRVVLFSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYK
||.. . |||. |   ..   |   .|     |..|||  . ..|  . .|.|.      .||| | .     .   || .| |. .|  .|| |..| |
kgvqalvdefrvl...akktpe.gvtveafsantdknryqd.vkcq.dkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqek

AGTIVMLNTLEETGQTY-TEYWPTEHP--EIYGSVlVEPLSNDNYGDFTMR---------RLKVSsYTEQSHvIVRHFSYFNWPDKSGPANYQSALELMS
  ...||  . |...    .||| |.    ..|.   . .| .| |  ..           |||  ....|   ..|. . ||||.  |    .|..|..
vesvimlckvielakikceqywpleegqklvfgea.pntisvanlgakklapdedlinvttlkvd.waqksr.tiqhlqwenwpdrgvpqinltainlle

EVQRSQqqaknRPIIVQCSNGTTRSGAFCAIYSILERL-KIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYL
 |.  .      |..| || |  |||.  ||  . ... . .   |. .... .| .|. .. . |||.  . . | |.
avrydt.....npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
0036941 (Phosphotyrosine protein) phosphatases II 261-526 4.5e-70 231.6 In-house 11-278 (297) alignment 
Range on Protein: 261-526
Range on HMM: 11-278/297.0
GITGFADEFQRLrlvSDSIKEDETNVAKNLQNQNKNRDMEYLPCElnSSRVVLfsTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKA
.....  ||..|    . ..  ...||....|..||| . .||..  ..||.|  .. . ||||||. | |.    ||.||.|. .|. .|||||.... 
flalllkefeel...lpllllgslsvallpenleknRykdilpyd..htRVkl..ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

GTIVMLNTLEETGQ-TYTEYWPTE--HPEIYGSVLVEPLSNDN--YGDFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQ
 .||||..|.| |  .. .|||.|  ..  || . |. || .   ..|.|.| |.|. . .. . .|.|| |..||| . | ...| |... .|.. ...
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

A-KNRPIIVQCSNGTTRSGAFCAIYSILERLK---IEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLD
. .. |..| ||.|  |||.|.|.. .|..|.   .|. ||.....| .| .||..|..| ||. .||. | .| 
lpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 261-532 1.7e-65 216.2 In-house 18-287 (318) alignment 
Range on Protein: 261-532
Range on HMM: 18-287/318.0
GITGFADEFQRLRLVSDSIKEDETnvaKNLQNQNKNRDMEYLPCELNSSRVVLFSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKA
| . .  |..||  ..... . ..    .  |..||| .  |. .    ..  .......|||||.. | |...  .| .|||...|  .||||| . ..
Gelllseeyerlsrseetvtslks...lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqns

GTIVMLNTLEETGQT-YTEYWPTEHPEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQAKNR
 .||||  .|| |..    ||| . .. ||.. ||  .. ...|...|..||.   |... .|| . | .|||.. |..  | |.|. .|.. ||.....
avivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgag

PIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLDTFGDYA
||.| || |  | | |.|. ..|||.| |..|||||..| .| .|.  |    ||. .|.. | .| ..  ..
pivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 261-522 7.3e-23 75.6 In-house 25-287 (310) alignment 
Range on Protein: 261-522
Range on HMM: 25-287/310.0
GITGFADEFQRLRLVSDSIKEDEtnvaKNLQNQNKNRDMEYLpCeLNSSRVVLFSTK-KEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYK
|| |.. ....|    ||    |       ..  |||  . . | |..||| |   | .  ||| | .  .   |. || .| |. .| ..||||..| .
gieglvkqyrkldakqdssltye....aykkymhknrysdvv.c.ldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqer

AGTIVMLNTLEETGQTY-TEYWPTE-HPEIYGSVLVEPLSNDnYGDFTMRRLKVSSYT------EQ----SHVIVRHFSYFNWPDKSGPANYQSALelms
| .|..|    | |.     |||.    | || . |  ||.    .| .  | |.         ||     .. |    . ||||.  | .   ..    
aesilllckvgeegrpkcvgywpslgvtetygcirvtnlses.seefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtv....

eVQRSQQQAKNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMAL
  ||   | .  | .|.|| |  | .. .|.   ...|.  . ||. .|.  .. .| . . .  ||.    . .
.pqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri
0040438 (Phosphotyrosine protein) phosphatases II 262-527 8.2e-70 230.9 In-house 17-278 (317) alignment 
Range on Protein: 262-527
Range on HMM: 17-278/317.0
ITGFADEFQRLRLVsdsiKEDETNVAKNLQNQNKNRDMEYLPCElnSSRVVLFSTKK--EADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYK
 |.. .||..|. .    | |...||. ..|..||| . .||..  .|||.| ....  . ||||||. | ..... ||.||.|. .|.  |||||....
ftalleefedllsl....kldtysvaelpenkdknrypdilpyd..hsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqg

AGTIVMLNTLEETG-QTYTEYWPTEHPEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQqAKN
 ..||||..||| | ... .|||....  || . |. || . ....|.|.|.|. . .. ...|.|| | .||| . | . .. |.....|.....  ..
vtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpg

RPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLDT
 |..| ||.|  |.|.|.|.| .||.|. |. |||....| .| .||..|....||. .|...| || .
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 262-527 1.2e-48 160.7 In-house 14-278 (281) alignment 
Range on Protein: 262-527
Range on HMM: 14-278/281.0
ITGFADEFQRLRLVSdsiKEDETNVAKNLQNQNKNRDMEYLPceLNSSRVVL--FSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYK
 .||. |.. |. .     .. .. .|. .|..||| .       . .||..   ...|..|||||.| ..||.   .| ||.|. .. |.||.||...|
naGfieeyeklaaig...vdntataskadenvlknrYsniva..YDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqk

AGTIVMLNTLEETGQT-YTEYWPTEH-PEIYGSVLVEPLSNDNYGDFTMRRLKVsSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQAK
. .|||.    |.|.     ||| ..   .|| | |. ... .   .  |..|. . ..  .. |... | .|||.  ||. .  ||  .||.. ... .
vsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekkt

NRPIIVQCSNGTTRSGAFCAIYSILERLKIE-QVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLDT
. |... || |  |.|.. |.  ...... | . .|| .|.. .| .|   | ...||   | . |..|| 
kaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_egg_pd Subfamily egg 262-525 4.2e-26 86.3 In-house 9-271 (307) alignment 
Range on Protein: 262-525
Range on HMM: 9-271/307.0
ITGFADEFQR-LRLVSDSIKEDETNVAKNLQNQNKNRDmEYLPCElNSSRVVLF--STKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQY
.. . .|..| | .. .|..|   . | .  |..| |. . ..|. .|||| |     .   |.| |   .     . ||..|||.  |  .|||||.| 
lseivqelerrlevleesvdeislttaasdnnlekars.krvhck.dssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqe

KAGTIVMLNTLEETgQTYTEYWPTEH--PEIY--GSVLVEPLSNDNYGD--FTMRRLKVsSYTEQSHVIVRHFsyfNWpDksgpANYQSALELMSEVQRS
.   ||||..  |. .    |||  .  . ..  ||. .| |  |.  |  |.. .||.   ...    . |.   .. |     |. | .    .| | 
evqyivmltsrkes.erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGgddeerflehw...qg.d....vnnssdvysplrvlrk

QQQAkNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQ--VVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMAL-RYL
 ...  .|..||. .| ...... ||   |  |         | . .. .| .|. || |  .|.  | . |  . 
lrnl.skpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
subfamily_Ptp69D_pd Subfamily Ptp69D 263-526 4.8e-61 201.5 In-house 22-287 (307) alignment 
Range on Protein: 263-526
Range on HMM: 22-287/307.0
TGFADEFQRLRLVsdsIKEDETNVAKNLQNQNKNRDMEYLPCELNSSRVVLFSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGT
 |.| |...|        . .|.|...  |. |||  .  . . .  ..     |...|||||||  .|||.  ||. |.|. .|  .||||... .  .
fglakeyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtl

IVMLNTLEETGQT-YTEYWPTEHPEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQS-----HVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQA
||||  |.|. .     ||| |.   ||..||.. |... .|...| |.||   |.|     .  |  ..| .|.|   |   .. |.|...|.  ... 
ivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln

kNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLD
 . ||.| ||.|. ||| | |. |.|..|| |. ||.|...| .| .|.  |.||.||| .|   | | .
.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_PTPRB_pd Subfamily PTPRB 263-525 6.8e-59 194.3 In-house 25-285 (293) alignment 
Range on Protein: 263-525
Range on HMM: 25-285/293.0
TGFADEFQRLRLVSdsiKEDETNVAKNLQNQNKNRDMEYLPCELNSSRVVLFSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGT
..|..|...|..|    |. ....|.. .|..|||  . || . .  ..   ......|||||.. . |. .  || || |. .|. .|||||.. |. .
lrfseeyeelkavg...kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssi

IVMLNTLEETGQTY-TEYWPTE-HPEIYGSVLVEPLSNDNYGDFTMRRLKVSSytEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQ-QQAKNR
||||  | | |..   ||||.. .| .||.. |. ...... |...| ||..   |...  ||.. .  |||   | . .. |... .|.... ..|..|
ivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskr

PIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYL
||.| || |  |.|.| |.  .|.... |..||.| ..  .| .| . | . .||.  ..  |..|
PivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 263-524 1.2e-53 177.4 In-house 23-287 (325) alignment 
Range on Protein: 263-524
Range on HMM: 23-287/325.0
TGFADEFQRLRlvsdSIKEDETNVAKNLQNQNKNRDMEYLPCElnSSRVVLFSTKK--EADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKA
 ||| ||. |     |      .||   .|..|||  . .. .   ||||| . |.  ..||||||.   .|..| |. .|||.|.|. ..||.|.....
dgfahefgllp....sddgiakkvamkpenkaknrfknvvald..ksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrc

GTIVMLNTLEETGQTYTEYWPTE--HPEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQSHVIVRHFSYFNWPD---KSGPANYQSALELMSEVQRSQQQ
  .|.|| |..  .  . ||| |  .   .|.. |.  . ... |. .|.|.|    .     |. | .  |.|   .  ||   | |.|. .|.   . 
svvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservta

--AKNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRY
      ||.| ||.|  |.|.| ..||.|...  |  ||.|...| .| .||. | .  ||. .||    .
ntkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea
subfamily_PTPN12_pd Subfamily PTPN12 263-523 7.1e-52 171.1 In-house 8-275 (290) alignment 
Range on Protein: 263-523
Range on HMM: 8-275/290.0
TGFADEFQRLRLVSDSIKEDE---TNVAKNLQNQNKNRDMEYLPCELNSSRVVLFSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYK
  || |||.|. .|.  |...   |..... .|..|||  . || . .   .   . ... |||||.|    ...  .| .|.|...|  .||||.....
eefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwekn

AGTIVMLNTLEETGQTY-TEYWPTEH--PEIYGSVLVEPLSNDNYG-DFTMRRLKVSSYTEQShvIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQq
   .||.  . | |..    ||| |.  .  .|.. |.  ....   ||..| |||    |.   .|. | | .|||.  |.. .| |||...|.. |. 
veivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesr..kvyqfhYtaWPDhgvPssaksllelielvrelqe.

AKNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQV---VDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALR
... |..| || |  | |. .||  . | || |..   .|||...  .| .|.  | .  ||.  |.  . 
sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae
0046845 (Phosphotyrosine protein) phosphatases II 264-533 5.2e-71 234.6 In-house 1-282 (284) alignment 
Range on Protein: 264-533
Range on HMM: 1-282/284.0
GFADEFQRLRLVSDSIKeDETNVAKNLQNQNKNRDMEYLPCElnSSRVVLFSTKKE---ADYINASFADAY-----KERDLFIMTQAPMTQTTVEFWRMV
|. .||..|. .  ..   ...||. ..|..||| . .|| .  .|||.| |....    ||||||. | |     . .  ||.||.|. .|. .|||||
gleeefeellsltvkll.lslsvallpenlsknRykdilpyd..hsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmv

MQYKAGTIVMLNTLEETGQ-TYTEYWPTEH-PEIYGSVLVEPLSNDNYGDFTMRRLKVSSYT-EQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRS
..... .||||..|.| |.  .  |||.|. . .|| . |. || ....|.|.|.|... .  .. ...|.|| |..||| . |.. .. ||.. .|...
weqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrel

QQQ-AKNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQ---VVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLDTFGDYAN
...  .. ||.| ||.|  |.|.|.|.. .||.|. |.   .|||....| .| .||..|..|.||. .||..| || ..  ...
lenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 264-531 8.2e-50 164.2 In-house 16-299 (301) alignment 
Range on Protein: 264-531
Range on HMM: 16-299/301.0
GFADEFQRLRlvsdSIKEDETNVAKNLQNQNKNRDMEYLPCelNSSRVVLFST----KKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYK
.|......|.    . ......|  . .|.. ||  .  .   .  |..|  .    ... .|||||. |.|.|.  ||..|.|| .| |.|||...|.|
kfeeqykelk....egedksctvglseenkalnrfknitvy..ddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqek

AGTIVMLNTLEETG-QTYTEYWPTE--HPEIYGSVLVEPLSNDNYGDFTMRRLKVS-------SYTEQSHVI--------VRHFSYFNWPDKSGPANYQS
  .|||.  |.|.  .  ..|||.   . | .| . |.  .. .| ||..|.|.|        .|.|..  .        |  .   .||.     ... 
pvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprt

ALELMSEVQRSQQQAKNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLDTFGDY
 |. . .|   ||.    |..| ||..  ||| .|..   ||  | | |||||||.| .| ..|  || | ||.| |..  .||     |
vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 265-532 5.3e-43 142.1 In-house 22-285 (439) alignment 
Range on Protein: 265-532
Range on HMM: 22-285/439.0
FADEFQRLRLVSDSIKEDETNVAKNLQnQNKNRDMEYLPceLNSSRVVL--FSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGT
| ..|. .  .|   . . . .|.. . | |||  .  .  .. .||.|        . |||| . . | . .|.| ||.|  .|| .|||.|.. |. |
fkeifekinstspdyaciaslaaqeyd.qtknrykdvga..fdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvt

IVMLNTLEETGQtyteYWPTEHPEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTE--QSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQAKNRP
||||  | |. .    |||..   .|| . |    | .  ....| .||    .  .    | .| |  ||||  ||.    |...  .. .... .  |
ivmltnlvesyk....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygp

IIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLdTFGDYA
..|.|| |  |.|.  |.   ||.||.|. ||.  ..||.| .| | | .|.|||  |.  |  .  .|| |
vvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi.vyGdia
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 265-524 2.8e-40 133.0 In-house 8-258 (267) alignment 
Range on Protein: 265-524
Range on HMM: 8-258/267.0
FADEFQRLRLVSDSIKEDETNVAKNLQNQNKnrdMEYlPCELNSSRVVLFSTKKEadYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIV
.  ||. .. .||      . .|.. |..|.   ...  .  . .||.|  ...|  |||||. ..|| .  ||.|| |. .|  .|. .....|  .||
iekefelikkisdtsstisqsiaeknqernr...ldd.nlpyddtrvilrtkeee..yinasyvegyktknafivtqdplkntitdfltvihdqkvpviv

MLNTLEEtGqTYTEYWPTE--HPEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQSHVIVrHFSYFNWPDKSGPANYQSAleLMSEVQRSQQQAKNRPII
.| .  . .     .|| .  . . |  . ||   . .  |. .  |..    | .| ..  . | .|  ..    |     |.  . . | .  |||..
lltkvft.d.nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvt.lyyykkwnintnnkpylkp..lfgilaknqlengnrPlv

VQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRY
|.||.|  |||.|  |.| |||.| |.|.|.|. .. || .|.  | .. .|. ..|.   |
vacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 266-529 3.3e-69 228.4 In-house 26-287 (319) alignment 
Range on Protein: 266-529
Range on HMM: 26-287/319.0
ADEFQRLRLVSDSikedETNVAKNLQNQNKNRDMEYLPCElnSSRVVLFS--TKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTI
. ||. |.  ..     ... |.. .|..|||  . |...   .|||| .   ....||||||| |.|.||. || ||||. .|. .||||| .... ..
ekefkllkeavnd....tfdsaskeenkkknryqnilayd..rtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessiv

VMLNTLEETGQT-YTEYWPTEHPEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQS-HVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQAKNRPI
|||. | | ..  . .|||.|..| || ..|.......  |. .|.||.   ...     | || | .|||.  | . .| |.|. ....|... ...||
vmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPi

IVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLDTFG
.| ||.|  | |.|...  .|||.| |.|.|||.... .|..|.  |   .||  .||  | ..... 
vvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_PTPN13_pd Subfamily PTPN13 266-526 4.9e-43 142.4 In-house 14-270 (273) alignment 
Range on Protein: 266-526
Range on HMM: 14-270/273.0
ADEFQRLRLVSdsiKEDETNVAKNLQNQNKNRDMEYLPCElnSSRVVLfstKKEADYINASFADAY--KERDLFIMTQAPMTQTTVEFWRMVMQYKAGTI
|.||. || .      |...|.|. .|..|||  . ||..   .|| |   ..|. |||||.  .   |..  .|..| |. .|. .||.|| . ||  |
aeefkelrelk...pldtcevgkkkenkdknryrnvlPyd..etrvkl...gdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevi

VMLNTLEETGQTY-TEYWPTEHP---EIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQqaKNR
.|. .  |.|.     ||| ..     ... . || |   .. .|..|.|.|.    .    | |. . .||| . |.. .. |....||.| |.  .. 
amvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dag

PIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLD
||.| || |  |||.. .|. .|. .. .. .|| .... .| .|   | .  ||. .|. .|  | 
PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
0045098 (Phosphotyrosine protein) phosphatases II 267-526 4.2e-60 198.8 In-house 11-273 (278) alignment 
Range on Protein: 267-526
Range on HMM: 11-273/278.0
DEFQRLRLVSDSikeDETNVAKNLQNQNKNRDMEYLPCELNssRVVlfstkkeaDYINASFADAYkeRDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVML
 ||..|.| ..    .| ..|  | |..||| ...||.. .  ||.        ||||||. | |  .. ||.||.|. .|.  ||||. ...  .||||
lefefllllgip...seitpalylgnldknRykdilpydhs..rVk........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivml

NTLEETG-QTYTEYWPTEHPEIYGSVLVEPLSNDNYGDFTMRRLKVSSY----TEQSHVIVRHFSYFNWPDKSGPANY--QSALELMSEVQRSQQ-----
..|.| | . . .||| .....|| . |. || ....|.|.|.|.|       ..     |.|. |..||| . | .   .| |||. .... ..     
telvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasl

-------QAKNRPIIVQCSNGTTRSGAFCAIYSILERLkiEQVVDVFQVIKVIRIKRPQ-SVTSLAQYVSCYEMALRYLD
       . .. |..| || |  |.|...|.| .||.|  |..||.....| .| .||. .|..| ||. .||..|..| 
llsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
DSPc_SM00195 268-525 5.1e-65 214.8 In-house 5-262 (263) alignment 
Range on Protein: 268-525
Range on HMM: 5-262/263.0
EFQRLRLVSDSIkedETNVAKNLQNQNKNRDMEYLPCElnSSRVVLFSTK--KEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVM
||..|.    .    ||. |.  .|..|||  ..||..  ..|| | ...  .. |||||.. . ....  .|.||.|. .|  .|||||.. |  .|||
efekleestspk...etteaekkknksknRyknilpyd..htrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LNTLEETG-QTYTEYWPTE--HPEIYGSVLVEPLSNDNYG-DFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQAkNRPI
|.  || | .. ..||| |  ..| .|.. |.  .....  ....| |...  ... .  |... | ||||.. | . .| |||...|. |...  . ||
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

IVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYL
.|.||.|  |.|.|..| .||..|. |. ||.|...| .| .||..|..|.||  .||..|.|.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 268-525 5.1e-65 214.8 In-house 5-262 (263) alignment 
Range on Protein: 268-525
Range on HMM: 5-262/263.0
EFQRLRLVSDSIkedETNVAKNLQNQNKNRDMEYLPCElnSSRVVLFSTK--KEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVM
||..|.    .    ||. |.  .|..|||  ..||..  ..|| | ...  .. |||||.. . ....  .|.||.|. .|  .|||||.. |  .|||
efekleestspk...etteaekkknksknRyknilpyd..htrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LNTLEETG-QTYTEYWPTE--HPEIYGSVLVEPLSNDNYG-DFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQAkNRPI
|.  || | .. ..||| |  ..| .|.. |.  .....  ....| |...  ... .  |... | ||||.. | . .| |||...|. |...  . ||
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

IVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYL
.|.||.|  |.|.|..| .||..|. |. ||.|...| .| .||..|..|.||  .||..|.|.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 268-522 4.1e-48 159.3 In-house 39-288 (319) alignment 
Range on Protein: 268-522
Range on HMM: 39-288/319.0
EFQRLrlVSDSIKEDETNVAKNLQNQNKNRDMEYLPCELNSSRVVLFSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLN
||.|.     ...  . . |   ||..||| .. |. . |  ..     .  .||||||| . |. .| .| .| |.  |  .||||. .|.. |||.| 
efrra..cklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt

tleetGQTYTEYWPTEHPEIYGSVLVEPLSNDNYGDFTMRRLKVSS-YTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRS-QQQAKNRPIIVQC
      .  ..||| .  . ..   |.  | ..  ....| ...|    |.    .. | .  |||.  |      . |.  |.   ... ....|.| |
.....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhc

SNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMAL
| |. |.|.. ..  .|.|.| |. |||..... .| .|.. | .|.||  .|   |
saGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 268-527 6e-38 125.3 In-house 15-279 (287) alignment 
Range on Protein: 268-527
Range on HMM: 15-279/287.0
EFQRLRLVSDSIKeDETNVAKNLQNQNKNRDMEYLPCELNssRVVLF-STKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVML
|...|.  |.|        |..| . .|||  . || . .  ||.|   ... .||||| .  .|.. . || .|.|.. |  .|||.|.. .. .....
evdalkedsesst.atfkaaeelaavkknryadvlPiddt..rvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitm

-NTLEETGQTYTEYWPTE-HPEIYGSVLVEPLSNDNY-GDFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPAN----YQSALELM--SEVQRSQqqAK
   .||. .   .|||    |   |   |  |. |.   ....| |..     .   .|. . ...||||. .       . .|.     |..|.   ..
treveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielarda..se

NRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLDT
  |..| .. |  ||| . |.. ...||.    ||| .|.  .| .|   | .  |.   ||    |  |
vGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt
subfamily_CG7180_pd Subfamily CG7180 269-525 3.7e-52 171.8 In-house 19-290 (296) alignment 
Range on Protein: 269-525
Range on HMM: 19-290/296.0
FQRLRLVSDSIKEDETNVAKNLQNQNKNRDMEYLPCELNSSRVVLFSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNT
.. .  .   .. ..   . ...|..|||| . .| . |   .  .  ... |||||.. |..     .|.|.||...|  ||||.| . .. ..|.|  
yklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtk

LEETGQTYTEYWPTEHPEIYGSVLVEPLSNDNYGDFTMRRLKVSSY----T------EQSHVIVRHFSYFNWPD-KSGPANYQSALELMSEVQRSQQQA-
  .  . | .||| .  | || ..|| .....| ....| .|.       |      .    ||..| .  |.  .. |   .. .||.  |.  .... 
tfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvd

---KNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYL
   .. |..| .|.|..|||...||   || ...|. ||||. .| .|..||| | .  .|  .|.. | ..
edpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_ptpA1_pd Subfamily ptpA1 271-485 2.8e-23 77.3 In-house 26-256 (418) alignment 
Range on Protein: 271-485
Range on HMM: 26-256/418.0
RLRLVSDSIKEDETNVAKNLQNQNKNRDMEYLPCELNSSRVVLFSTKKEADYINASFADAYKERDlFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLE
 .||. .|.   ||.   . .| .|||  . || .    ..     |. .||||| . |    .. || || |. .|  .||||| . ..  ||||.   
efrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrcriivmlsres

ETGQT-YTEYWPT----EHPEIYG-------SVLVE--PLSNDNYGDFTMRRLKVSSYTEQSHviVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQ-
|  .     |||     |.  |||       .  ||   . .|   .   | ....   |     . .. |  |||.  |   |   .|.  .   |.| 
encrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrd..itqyqyegwpdhnipdhtqpfrqllhsitnrqnqi

----AKNRPIIVQCSNGTTRSGAFCAIYSILERL
     .| ||||.|| |  |.|.||.   ....|
ipssdrnvpiivhcsagvgrtgtfctavimmkkl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 272-382 3.7e-13 43.9 In-house 26-152 (350) alignment 
Range on Protein: 272-382
Range on HMM: 26-152/350.0
LRLVSDSI-KEDETNVAKNLQNQNKNRDMEYLPCElnSSRVVLF----------STKKEADYINASFADAY-----KERDL-FIMTQAPMTQTTVEFWRM
| | |||  . ..  ... ..   |||  . || |   ||| |            . .  |||||..          . |  .| ||||. .|  .|...
lsLesdsespsnDvilseGvelfaknrYknilPYe..hsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykv

VMQYKAGTIVMLNTLEETGQ-TYTEYWPT
... |   |..|... | .   . .||. 
illnkvkvilsltsdvelnlekcyrYWqe
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 273-523 4.6e-48 158.5 In-house 14-264 (283) alignment 
Range on Protein: 273-523
Range on HMM: 14-264/283.0
RLVSDSIKEDETNVAKNLQNQNKNRDMEYLPCELNssRVVLFSTKKeaDYINASFAD---AYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTL
.|   |. . ....| . .|..|||  | .| . .  || | |  .  |||||.|      ||.   .|..|.|. .| |.||.|| . |. .||||  |
vlkrlsvpdldadiasadenkrknrnqeivpadqw..rvelksesr..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltkl

EETG-QTYTEYWPTEHPEIYGSVLVEPLSNDNYGDFTMRRLKVSSY-TEQSHVIVRHFSYFNWpDKSGPANYQSALELMSEVQRSQQQAKNRPIIVQCSN
 |   .  . ||| .  | ||   |    .     |... | .    . .| ... |. . .|  . |.     .|  .  |.  |.. |. ||.| ||.
qedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW.leygeqaiinslvkfnkvislqteskkgPivvhCst

GTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALR
|  |...|.|. . .. .. | |||||.|.|..| .|.  | .| ||   .|..| 
giGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 277-525 4.9e-29 96.3 In-house 27-271 (288) alignment 
Range on Protein: 277-525
Range on HMM: 27-271/288.0
DSIKEDETNVAK-NLQNQNKNRDMEYLPCelNSSRVVLFstKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQT
|| .|   ....  ..|  ..|  .   |  . .|| |        ||.|    . | .  .| .|||.  |  |.|.|...     ||||. | | |. 
dspneasidiidsfianptrdryenlprc..ditrvkls..ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGke

-YTEYWPTEHPEIYGSVLVEPLSNDNYGD----FTMRRLKVSSYTeQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVqrsqqQAKNRPIIVQCSNGTT
   ||.|..  |      .     ... |     ..  |..|  . . .|||..  . .|.|.. | ||.| | |.  .     .. ..||.|..|.|. 
ksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskeg.eekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvG

RSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYL
|.|..  |  .|| |...  . . ....  | .| .....  ||.  . . | .|
rtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 278-527 8.6e-68 223.7 In-house 34-285 (305) alignment 
Range on Protein: 278-527
Range on HMM: 34-285/305.0
SikEDETNVAKNLQNQNKNRDMEYLPCELNSSRVVLFSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQ-TY
   |. ..| |. .|..|||  |  . . .  ..   ......||||||. |.||... .|..|.|. .| ..|||.....|  |||||  | | |.   
e..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkC

TEYWPTEHPE--IYGSVLVEPLSNDNYGDFTMRRLKVSS-YTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQAKNRPIIVQCSNGTTRSG
  |||... |   .|.. ||  |. .. |...|.||.|   ...    | ..   .|||.  |    | |.|. .||..|.. |. |..| ||.|  |.|
rqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtG

AFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLDT
.|.|.   ||||| |.|||||.|.| .| ||.. |..|.|||.....   .. .
vfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 278-513 1.8e-26 87.6 In-house 36-269 (301) alignment 
Range on Protein: 278-513
Range on HMM: 36-269/301.0
SIKEDETNVAKNLQNQNKNRdMEYLPCELNSSRVVLFSTKKEAdyINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNT-LEETGQTY
.|. |. . .    ...|.| .. .||. ...  |.   |.    | | . ..  . . || ||.|...|. .|| |..||.  .||||   .|.. .  
tidkdhitesyaylpkdkhr.yptvPckPstavevivdGkrvP..ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekc

TEYWPTEHPEIY--GSVLVEPLSNDN--YGDFTMRRLKVSSYTEQ-SHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQqqaknRPIIVQCSNGTTR
.|| |.. .|    |   ..  ...     . . |.|.|   |.. .   | |. | .|.|.  |  .    .||  |..|.     .||.|.||.|  |
eeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse.....kPivvhcsaGiGr

SGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQ
| || .   .  ... .. ... . .| .| .| ..|    |
svafigteylareveadptieltealkhlrehrwngvqtnsq
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 280-523 1.2e-47 157.8 In-house 13-253 (284) alignment 
Range on Protein: 280-523
Range on HMM: 13-253/284.0
KEDETNVAKNLQNQNKNRDMEYLPCELNSSRVVLFSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNtleetGQTYTEY
.  . . |   ||..||| .. |. . |  ..     .  .|||||||   |. .| .| || |.  |  .||||. .|.. |||.|       .  ..|
ngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkcsqy

WPTEHPEIYGSVLVEPLSNDNYGDFTMRRLKVSS-YTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRS-QQQAKNRPIIVQCSNGTTRSGAFCA
|| .  . ..   |.  | ..  ....| ...|    |.    .| | .  |||.  |      . |.  |.   ... ....|.| || |. |.|.. .
wplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyiv

IYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALR
.  .|.|.| |. |||..... .| .|.. | .|.||  .|   | 
ldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 280-526 5.1e-43 142.0 In-house 8-265 (270) alignment 
Range on Protein: 280-526
Range on HMM: 8-265/270.0
KEDETNVAKNLQNQNKNRDMEYLPCElnSSRVVLFS--TKKEADYINASFAD-AYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQTY
...|... .  .... || .. ||     .||.| .  ..... |||| .   . .|.  .| ...|.  |. .||||... |. .|||.  ||| |.. 
etsesdlpeaargkklnRyadiLPsP..atRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkk

-TEYWPTEHPE----IYGSVLVEPLSNDNYGDFTMRRLKVSsYTEQSHVIVrHFSYFNWPDKSGPANYQ------SALELMSEVQRSQQQAKN-RPIIVQ
   |||.|  |     .| . |  ||. .   . ..||..  .. ... .| || | .|||.. | . .      . |... .|.||... ..  |..| 
CerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvH

CSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLD
||.|  |.| . |.  ... |. .. ||| ..|. .| .|.. |    ||   |.  . | .
csaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_PTPN1_pd Subfamily PTPN1 280-501 1.1e-37 124.4 In-house 20-247 (290) alignment 
Range on Protein: 280-501
Range on HMM: 20-247/290.0
KEDETNVAKNLQNQNKNRDMEYLPceLNSSRVVLfsTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQ-TYTE
.. .|..||. .|.|.||  .  |   . ||..|   ... ||||||. .. . .  .|.|| |...|.  ||.|| . |. ..|||| . | .|   ..
sdfptreaklpenrnlnryrdvsp..ydhsrikl..eradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaq

YWPTEHP--EIYG---SVLVEPLSNDNYGDFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQAKN-RPIIVQCSNGTTRS
|||...   |.     .. |. .|....  .|.| |..   . |    . || |  ||| . |   .. |... .|..|   ...  | .. || |  ||
ywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrs

GAFCAIYSILERLKIEQV---VDVFQVIKVIR
|.|| . ..| ... ..    ||. .|.  .|
Gtfclvdtclvliekkddlssvdikkvllelr
subfamily_PTPN14_pd Subfamily PTPN14 280-526 4.1e-34 113.0 In-house 37-297 (300) alignment 
Range on Protein: 280-526
Range on HMM: 37-297/300.0
KEDETNVAKNLQNQNKNRDMEYLPCElnSSRVVLFSTKK-EADYINASFADAY--KERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQTY
.. ....||. .|..|||. . || |   .|| | .||. . .|||||   .    ..  .|..|.|. .|  .||.|| . .   ||||   || |.. 
edallstaklpenaeknrfkdvlPye..dnrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkek

-TEYWPTE---HP-EIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRS----QQQ----AKNRPIIV
  .|.| .   .    .|   |    ... . .. . ||.     . .  | |. | .|||.  | . .. |. . |||      ...     .. |..|
sfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlv

QCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLD
 ||.|  |.|       ... |. ....|. .|.. .| .|   | .||||   |.. ..||.
hCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 280-366 2.1e-07 24.8 In-house 32-116 (347) alignment 
Range on Protein: 280-366
Range on HMM: 32-116/347.0
KEDETNVAKNLQNQNKNRDMEYLPCElnSSRVVLFSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVML
.| | ...||  .. |  |   .       .     . .   |||||     . .  .|.|| |. .|  .||.||.  |   .| .
vewekslsknrskdvklidatrvvls..peksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_PTPRK_pd Subfamily PTPRK 281-523 5.6e-60 197.8 In-house 33-275 (314) alignment 
Range on Protein: 281-523
Range on HMM: 33-275/314.0
EDeTNVAKNLQNQNKNRDMEYLPCElnSSRVVLFSTKKE--ADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETG-QTYT
|   ..||. .|..||| .. |. .   |||.| ... .  .|||||.. |.||    ||.|| |. .|. .|||.| .... .||||. | |.|    .
eg.wdaakkdenreknrsgdilayd..rsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkCl

EYWPTEHPEiYGSVLVEPLSNDNYGDFTMRRLKVSS--YTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQaKNRPIIVQCSNGTTRSGAF
.||| .    || . || .. .   .. .| ..|.    . . . .||.| . .|||   | . .. |.|. .|. ||.. .. .|.| ||.|. |.|.|
kyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtf

CAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALR
.|| ..|. .. |.|||||...| .| ...  |    ||. .|...| 
iaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_PTPRN_pd Subfamily PTPRN 281-516 1.3e-35 117.6 In-house 45-283 (297) alignment 
Range on Protein: 281-516
Range on HMM: 45-283/297.0
EDETNVAKNLQNQNKNRDMEYLPCELNSSRVVLFSTKKEADYINASFA-DAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQTYT-E
.  ..|||. .| .|||  . || . .  ..   ..... ||||||.  |    .  .| ||.|...|  .||.|| .  .  ||.| .|||.| . . .
pstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckr

YWPTEHPEIYGSVLVEPLSNDNYG-DFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQaKNRPIIVQCSNGTTRSGAFCA
||| |  |.|.   |. .|.  .  |. .| . .     .    |  | .. ||... ||. .| ||.   |..| .  .  ||.| ||.|. |.|....
ywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyil

IYSILERL-KIEQVVDVFQVIKVIRIKRPQSVTSLAQYVS
|  .|.|| |  . .|.   .. .| .||. | . .|.  
idlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfef
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 281-440 3.2e-22 73.8 In-house 22-184 (297) alignment 
Range on Protein: 281-440
Range on HMM: 22-184/297.0
EDETNVAKNLQNQNKNRDMEYLPceLNSSRVVLFSTKKEADYINASFADAYKE-RDL-FIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQT-YT
 ..  .||      |||  . |    ...|| |  .  | ||||| .    .|  || .|..| |. .|  .||..|..   ..|||.  |.| |.   .
gesfssakrnsslrknryrdila..tddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkca

EYWPTEHPE--IYGSVLVEPLSN--DNYGDFTMRRLKVSSYtEQSHViVRHFSYFNWPDKSGPANYQ
 |||    |    |.|.|| ||.  |..    .  |..    ..| | |||  ...|||.  |.. .
pywpsvvqerlkagdvvveflsstsdefdrviltelqliyr.sesrv.vrhvqflswpdhGvpsdle
subfamily_PTPRA_pd Subfamily PTPRA 282-525 3.2e-61 202.1 In-house 48-295 (330) alignment 
Range on Protein: 282-525
Range on HMM: 48-295/330.0
DETNVAKNLQNQNKNRDMEYLPCELNSSRVVLFSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQTY-TEYW
   ..|.. .|..||| .. || . .   .   . ..|.||||||| | |||.| || .| | ..|  .||||. ..|. |||||  |.|  ..  . ||
atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw

PTEHPEIYGSVLVEPLSNDNYGDFTMRRLKVS----SYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQAKNrPIIVQCSNGTTRSGAFC
|.|    || . ||   .    |.|.| . |     .  |... .|| | .  |||   |.. .  |.|. .|.. .||  . ||.| || |. |.|.|.
PdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfi

AIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYL
.. ..|||.| |..||||...| .| .||| | .. ||. .|.. | | 
vldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 282-523 5.3e-24 79.4 In-house 27-267 (281) alignment 
Range on Protein: 282-523
Range on HMM: 27-267/281.0
DETNVAKNLQNQNKNRDMeYLPCeLNSSRVVLF---STKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQ-TYT
|   | ..  |..||| .  .|| |. ||| |      |. .||| | .  .   .  .|.|| |  .|  .||||. | .. .||||  . || .   .
dlctvfnqpvnnkknryl.nipc.ldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekca

EYWPTEHpeiYGSVLVEPLSNdNYGDFTMRRLKVS-----SYTEQShVIVRHFSYFNWPDKSGPANYqsalELMSEVQRSqQQAKNRPIIVQCSNGTTRS
||.| .    .  . .. ||  .| | |. .  |.     ||  ..  .. |. . .|||   |       |.| .. |   .|.  | ...|| |  ||
eyfprna...hcclqfdklsv.syedstvnkslvttrlnlsyeget.rlithwlwkewpdwqvpess....evmlkilrk.irarstppvihcsagvgrs

GAFCAIYSILERLKIEQ-VVDVFQVIKVIRIK-RPQSVTSLAQYVSCYEMALR
|.. |.   |. ..    . |. |..  .|.  |  || .| ||.  ... | 
gtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
0040439 (Phosphotyrosine protein) phosphatases II 283-525 2.9e-62 205.8 In-house 2-246 (249) alignment 
Range on Protein: 283-525
Range on HMM: 2-246/249.0
ETNVAKNLQNQNKNRDMEYLPCELNSSRVVLFSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETG-QTYTEYWP
|..||. . |..||| . .||.. .  ..  ..     ||||||. | |.  . ||.||.|...|.  ||||. ... ..||||..|.| | ... .|||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

TEHPEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQA-KNRPIIVQCSNGTTRSGAFCAIYS
....  || . |. || . ..|.|.| |... . ..... |.|. |..||| . | . ...|... .|.  .... |. |..| ||.|  |.|.|.|.| 
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

ILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYL
.||.|. |. ||.....| .| .||..|... ||. .||..|..|
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 283-525 2.4e-53 176.2 In-house 42-284 (297) alignment 
Range on Protein: 283-525
Range on HMM: 42-284/297.0
ETNVAKNLQNQNKNRDMEYLPCElnSSRVVLFSTKKE--ADYINASFADAYKERdlFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQTYTEYW
.. ||..  | .|.|    || .  |||| | .. ..  .||.||||  ..|.|  .| || || .|  .||.||..... |||||| ..|. .  . ||
pqtvaekkvnfeksRYkniLPyd..ssRvkLaivnddpdsDyvnasfvkgnkhr..littqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryW

PTEHPEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPA--NYQSALELMSEVQRSQQQAKNRPIIVQCSNGTTRSGAFCAI
. .    .|.| |. || ..   |  | |.|.    ... .|. . . .||||. .   . .| |.|.|||. . .| .. |..| |..|  | | ...|
sdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvllti

YSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYL
 |.. . | |. ||.|...| .| .||. |    ||   |.. | .|
dsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 283-526 1.5e-51 170.1 In-house 35-278 (315) alignment 
Range on Protein: 283-526
Range on HMM: 35-278/315.0
ETNVAKNLQNQNKNRDMEYLPceLNSSRVVL--FSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQ-TYTEY
...||.. .|..|||  . ||  |.|.||.|     . . ||||||.  ....   .| .|.|   .  .|||||.|.|. ||||.. ..|  .     |
rqrvaretinfkknryknilP..ldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqy

WPTEH--PEIYGSVLVEPLSNDNYGDFTMRRLkVSSYTEQSHViVRHFSYFNWPDKSGPANYQSALELMSEVQRSqQQAKNRPIIVQCSNGTTRSGAFCA
|| ..     .||. || || .  .| ..|.| |   .|.|.  |  | . .||||  . .  | |.|. ||. . .. |. ...| || |. |.| ...
wPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrt.vtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvis

IYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLD
| ......| ...||||...| .| |||. | .  .|   |.  | .| 
idevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPN3_pd Subfamily PTPN3 283-521 1.5e-39 130.6 In-house 32-271 (280) alignment 
Range on Protein: 283-521
Range on HMM: 32-271/280.0
ETNVAKNLQNQNKNRDMEYLPCelNSSRVVLFSTKKeaDYINASFADAYK----ERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQTY-T
....|.  .| .|||  . ||   .. || | ....  |||||.. .           .| || |...|. .||.|| . |. .|||| || | |..   
aisaarkpenlsknryrdilpy..datrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

EYWPTEHPEI-YGSVLVEPLSNDNYGDFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRsQQQAKNRPIIVQCSNGTTRSGAFC
.|||... |. ||.  |.  ..|.   . .| | ..  ... .  . .. | .|||.. | . .. ||....|.. ....|..|..| || |  |.| . 
qyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrk.lrsgkeePvvvhCsaGigrtGvli

AIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMA
..   |  . ... | . .... .| .|   | . .||    |  
lletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 283-522 1e-34 114.6 In-house 36-233 (392) alignment 
Range on Protein: 283-522
Range on HMM: 36-233/392.0
ETNVAKNLQNQNKNRDMEYLPCElnSSRVVL--FSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGqtyteyw
...||..  |..|||  . || .  |.||.|       . ||.|||. ....    .| .|.| . .  .|||||.| .. ||.|.. |.|         
pqtvaqkeinlkknryknilpyd..sarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.......

ptehpeiygsvlveplsndnygdftmrrlkvssyTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQaKNRPIIVQCSNGTTRSGAFCAIYS
                                    ...  |  | . .||||  |    | |... ||.    |   .|.|..|| |  |.|   .| |
..................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGq.ythpliihcsagvgrtgvvisids

ILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMAL
.. . |  ..||||...  || |||  | .  ||   |   |
vvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 284-533 1.1e-123 406.3 In-house 1-250 (250) alignment 
Range on Protein: 284-533
Range on HMM: 1-250/250.0
TNVAKNLQNQNKNRDMEYLPceLNSSRVVLFSTK--KEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQTYTEYWP
..|||..||..|||......  |.||||||...|  ||.|||||||...|.||..||.||.|...|...|||||...|.||||||..|.|...||..|||
ksvakkpqnkeknryadiia..ldssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywP

TEHPEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQAKNRPIIVQCSNGTTRSGAFCAIYSI
.|..|.||.|.|..||.....|.|.|.||.|........|||......||||. |......|||...||.|||||.|.|.|||||.|..|||||.||...
vekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

LERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLDTFGDYAN
|||||.|.|||||.||||.|..||..|.||.|||..||..|..||...|||.
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
0049772 (Phosphotyrosine protein) phosphatases II 284-530 5.9e-30 100.5 In-house 38-285 (314) alignment 
Range on Protein: 284-530
Range on HMM: 38-285/314.0
TNVAKNLQNQNKNRDMEYLPCElnSSRVVLFSTKKEADYINASFADAYkeRDlFIMTQAPMTQTTVEF----------WRMV--MQYKAGTIVM------
. ||. . |..||| .. || .  . ... .   .  ||||||. | .  .. || ||.|.  | | |          ||||   ...  .|||      
ilvadlflnrdknryldilpad..nrvilpglpvsgsdyinasyvdgf..lk.fIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------LNTLEETGqtyteywptehpeiY----------GsvlveplsndnygdftmrrlkvSSYTEQSHVIV--RHFSYFNWPDkSGPAN
               |..| . |                                                . .......     .. ....||  ..  
adelsrLdaAlgKtpllildgng..............neptaadlellk......................eelydpelferlgikylripvpD.gsapl

YQSALELMSEVQRSqqqAKNRPIIVQCSNGTTRSGAFCAIYSILERLKieqvVDVFQVIKVIRIKRP-----QSVTSLAQYVSCYEMALRYLDTFGD
 .  .|..  ...     |..|..| |. |  |.| |.... .. .|.    |.. .... .| |||      .. .| ||. ..|  | ||... .
ledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylkflkk
0037934 (Phosphotyrosine protein) phosphatases II 285-524 3.4e-54 179.3 In-house 3-241 (243) alignment 
Range on Protein: 285-524
Range on HMM: 3-241/243.0
NVAKNLQNQNKNRDMEYLPCELnsSRVVLfstkKEADYINASFADAYKeRdlFIMTQAPMTQTTVE----FWRMVMQYKAGTIVMLNTLEETG-QTYTEY
..|. ..|..||| . .||..   |||.|    .  |||||.. . .. |  .| ||.|...|. .    ||||. ... ..||||..|.| | . . .|
siallpenlsknrysdilpydh..srvkl....egsdyinanliyvtp.r..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPtEHPeIYGSVLVEPLSNDNYGDFTMRRLKVSSYT-EQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQ-------AKNRPIIVQCSNGTTR
|| .    || . |. ||  ...|.|.| |... .  .. .  |.|. |..||| . | . .. |....||.  ...        ...|..| || |  |
wp.gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

SGAFCAIYSILERLkieQvVDVFQVIKVIRIKRPQ-SVTSLAQYVSCYEMALRY
.|...|.| .|..|   . ||.....| .| .||. .|... ||. .||..| .
tGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 285-522 2.6e-53 176.0 In-house 42-276 (315) alignment 
Range on Protein: 285-522
Range on HMM: 42-276/315.0
NVAKNLQNQNKNRDMEYLPCELNSSRVVLFSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQTYTE-YWPTE
.|||. .|..||| .. .. .    .. |  .....||.||.| | |. .. .| .|.| ...  .|||.|.... |.||||. | |  .  .| ||| .
dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk

hPEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQShvIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQqAKNRPIIVQCSNGTTRSGAFCAIYSILE
   ||| . |   |.. . ..|.| | | .  .     |  . |  |||   |.   . ..|.  |.. .. ..  .|.| ||.|  |.|.|... ..|.
.kviyGkitvtrkseevnteytvrtlsvvfgdnir..evvqlhytswpdmgvpkytiplmnlirtvkqhht.nsvgaivvhcsaGvGrtGtfitldavld

RLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMAL
....|...||...|. .| .| . | ...||   |.. |
qaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 285-525 1.2e-48 160.5 In-house 36-276 (515) alignment 
Range on Protein: 285-525
Range on HMM: 36-276/515.0
NVAKNLQNQNKNRDMEYLPceLNSSRVVL--FSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQT-YTEYWP
 ||..  | .|||  . ||  ..|.|| |     . . ||.|||.  ...    .| .|.|   .. .|||.|.|..  ||.|.. |.|  .   ..|||
tvaqeeinfkknryknilP..ydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWP

T--EHPEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEqSHvIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQAKnRPIIVQCSNGTTRSGAFCAIY
        .||. || .| .  .. . |.|.|    . |.  |  | . .||||  | . .| | |. ||. ...| .  |.|. || |  | | ...| 
dkpgdsvkfGsikvelvsleactggikrkltvlkgdd.sr.tvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisid

SILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYL
|.. . |  ..||||.....|| |||. |    ||   |.. | .|
svvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 285-525 2.9e-30 100.0 In-house 43-289 (305) alignment 
Range on Protein: 285-525
Range on HMM: 43-289/305.0
NVAKNL-----QNQNKNRDmEYLPCELNSsrVVLFSTKKEADYINASFADAYK-ERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQ-TYT
.|| |       .. |||  . .||. .|  .|...    .||| | .  .       || .| |. ||  ||| ||.| |   ||||    |.|.   .
qvafnanqsadiaitknry.qdvpcqdqs..avkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkca

EYWPT---EHPEIYGSVLVEPLSND----NYGDFTMRRLKVSsYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQqqaknRPIIVQCSNGTT
.|||.   |. |. . ..|| .|         .  .  |... |. . .. |||. . .|||.  |    ..|||.| .. |.      ||.|.|| |  
qywpaaqgeklelksgivvenvsgskpmerdaeiqitllnlt.ysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk.....vpivvhcsagig

RSGAFCAIYSILERLKIE-QVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYL
|.|.  ||  |||..  . ..  . ...| .| .|  |. .  ||.  . . | |.
rtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 285-434 6.6e-18 59.2 In-house 86-234 (244) alignment 
Range on Protein: 285-434
Range on HMM: 86-234/244.0
N---VAKNLQNQNKNRDMEYLPCELNssRVVLFSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETgqtyTEYWP
.    | | .|  |||.   || ..|  || |        ||||||         .|.|| |...|...||.|... .   .|.| ..||      ||||
svmkdafnpnnswknregaglpfdfn..rvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee....deywp

TEHP-EIYGS-VLVEPLSNDNYGDFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKS
   | | |   . |     |.. .     |.. |  ..||  .  |   |||   
dseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdg
subfamily_eak_pd Subfamily eak 285-437 8e-14 45.7 In-house 45-196 (332) alignment 
Range on Protein: 285-437
Range on HMM: 45-196/332.0
NVAKNLQNQNKNrDMEYLPCELNSsrVVLFSTKK-EADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVML-NTLEETGQTYTEYWPT
.... |.. |.|  .. .| . .   | | |... .  ||||| |.  .    .|.| ..  .    ||.||.. |. .||.| . .|.  . .  |.| 
setarleavnrn.vvkivpydryl..vrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpd

EHPE--IYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQSHviVRHFSYFNWPDKSGPA
.  |   .| . ||  .  . . . .| |..|   |  .  | |. .| | . . | 
ktreelkfGildverkefvkrniletrllelskGnethr..vlhykvfGwtettlpk
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 285-341 1.7e-07 25.3 In-house 41-94 (95) alignment 
Range on Protein: 285-341
Range on HMM: 41-94/95.0
NVAKNLQNQNKNRDMEYLPCElnSSRVVLfSTKKEADYINASFADAYKERDLFIMTQ
 |     |  ||| .. .| .  ..|||| .||...||||| | | |  .. .| .|
tvgsseanipknrflnifpyd..atrvvl.ttkrdsdyinacfvdgyarkncyiaaq
0042113 (Phosphotyrosine protein) phosphatases II 286-525 1.2e-61 203.6 In-house 3-243 (245) alignment 
Range on Protein: 286-525
Range on HMM: 3-243/245.0
VAKNLQNQNKNRDMEYLPCELNSSRVVLFSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQ-TYTEYWPTEH
||. . |..||| ...||.. .  ..   ..    ||||||. | |.  . ||.||.|...|.  ||||. ...  |||||...|| |. .. .|||...
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

PEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQAKNRPIIVQCSNGTTRSGAFCAIYSILER
.  || . |. || ....|.|.| |.|.   .  .  |.|. |..||| . | . .. |.....|.. ... .| |..| || |  |.|.|.|.| .||.
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

LKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYL
|. |. |......| .| .||..|... ||. .||..| .|
lekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 287-517 1.2e-31 104.7 In-house 3-233 (239) alignment 
Range on Protein: 287-517
Range on HMM: 3-233/239.0
AKNLQNQNKNRDMEYLpcELNSSRVVL--FSTKKEADYINASFADAYKE-RDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETG-QTYTEYWPT
||.  |. |||  . .    . |||||  .|    .||||||.   |      .| ||  .. .. .||||. | .   ||||  | |   .   .||| 
akkrvnkaknryaniv..tydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

EHpEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQqQAKNRPIIVQCSNGTTRSGAFCAIYSIL
     |  . |     . . |. .| . .|   .     | .. .  ||||  |    . | |  .. .       || ...|| |  |.|||  | ..|
st.skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkds.lpgarpwvihcsagvgrtgaflvidaml

ERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSC
 . | .. ||.|. .| ||  ||. | .  |||  
rqakkqktvdifnyvkairedrphmvqtseqyvfi
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 287-517 1.7e-31 104.2 In-house 2-232 (239) alignment 
Range on Protein: 287-517
Range on HMM: 2-232/239.0
AKNLQNQNKNRDMEYLpcELNSSRVVL--FSTKKEADYINASFADAYKE-RDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETG-QTYTEYWPT
||.  |. |||  . .    . |||||  .|    .||||||.   |      .| ||  .. .. .||||. | .   ||||  | |   .   .||| 
akkrvnkaknryaniv..tydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

EHpEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQqQAKNRPIIVQCSNGTTRSGAFCAIYSIL
     |  . |     . . |. .| . .|   .     | .. .  ||||  |    . | |  .. .       || ...|| |  |.|||  | ..|
st.skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkds.lpgarpwvihcsagvgrtgaflvidaml

ERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSC
 . | .. ||.|. .| ||  ||. | .  |||  
rqakkqktvdifnyvkairedrphmvqtseqyvfi
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 288-374 3.7e-10 33.8 In-house 30-115 (332) alignment 
Range on Protein: 288-374
Range on HMM: 30-115/332.0
KNLQNQNKNRdMEYLPCeLNSSRVVLFSTKKEADYINASFADAYKERDLFIMTQAPMTQT-TVEFWRMVMQYKAGTIVMLNTLEETGQ
| |.| . || . .| | .. ||| |     . |. |||. | | ..  .|..|||. .     ||||| . |   |...  ..|  .
kflnnmdmnr.iphlyc.fdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 289-520 6.6e-12 39.7 In-house 44-274 (303) alignment 
Range on Protein: 289-520
Range on HMM: 44-274/303.0
NLQNQNKNRDMEYLpCeLNSSRVVLfstkKEADYINASFADAYKERdLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQTYTEY-WPTEHPEI
 ..| .||| .. . | |. |.| |     .. || ||. .   ..   |.|| |...|. .||.|... |   ...| |  |  .   .. .| .   .
fvknmdknrfvdvi.c.ldhskvkl....sdssyihasyleldssk.kailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdfl

---YGSVLVEPLSNDNYGD-FTMRRLKVSSYTEQSHVIVRHfsYFNWPDKSGPAN-YQSALELMSEVQRSQ-QQAKNRPIIVQCSNGTTRSGAFCAIYSI
     |. |  . . . || .... | ||  . .| . | |  | .|| .| |..     .  . ..|    . ....| .     |  |.|.|. . . 
kfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhh..ykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfeta

LERLKIEQV-VDVFQVIKVIRIKRPQSVTSLAQYVSCYEM
   |. ||  .|. .... .|  | ..|  |.|.   | .
hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 290-526 6.4e-47 154.9 In-house 26-269 (274) alignment 
Range on Protein: 290-526
Range on HMM: 26-269/274.0
LQNQNKNRDMEYLPCElnSSRVVLFSTKKE---ADYINASFADAYKE-RDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQ-TYTEYWPTEH
  .|.|||  . || |   |||.| | . |   ..|||| .   |.|    .. || |...|  .||||. | ..  ||||  |.|. .   ..|.|...
fgsqtknryktilPne..nsrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

P----EIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQSHviVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQAKNR--PIIVQCSNGTTRSGAFCAI
     | || | ..  .  .  |...|.| ... ... .  | |. | .|||.  | . .. |.|. ||..|.......  |..| || |  | |.| ||
dyeiserygdveikvekiverndysvrklvlkylerers..vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai

YSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYLD
   . .|. |.||||....  .|..|   | .  ||   ...   || 
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
Y_phosphatase Protein-tyrosine phosphatase 292-522 1.6e-62 206.3 Pfam-A 1-234 (235) alignment 
Range on Protein: 292-522
Range on HMM: 1-234/235.0
NQNKNRDMEYLPCElnSSRVVLFSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEET-GQTYTEYWP--TEHPEIY
|..|||  ..||..  ..|| | ..... |||||.. . |||   ||.||.|. .|  .|||||.|.|  .||||..|||   ... .|||  .| .. |
nkkknRykdilpyd..ktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GSVLVEPL-SND-NYGDFTMRRLKVSSYTEQS-HVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQqQAKNRPIIVQCSNGTTRSGAFCAIYSILERL
|.. ||   ..  .  ..|.| |.... .|.| . .|... | ||||.. |....| |.|. .|..|. .||. |..|.||.|. |.| |.|.  .||.|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMAL
. |. |||.|..| .| .||..|.||.||. .|.. |
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 292-522 1.6e-62 206.3 In-house 1-234 (235) alignment 
Range on Protein: 292-522
Range on HMM: 1-234/235.0
NQNKNRDMEYLPCElnSSRVVLFSTKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEET-GQTYTEYWP--TEHPEIY
|..|||  ..||..  ..|| | ..... |||||.. . |||   ||.||.|. .|  .|||||.|.|  .||||..|||   ... .|||  .| .. |
nkkknRykdilpyd..ktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GSVLVEPL-SND-NYGDFTMRRLKVSSYTEQS-HVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQqQAKNRPIIVQCSNGTTRSGAFCAIYSILERL
|.. ||   ..  .  ..|.| |.... .|.| . .|... | ||||.. |....| |.|. .|..|. .||. |..|.||.|. |.| |.|.  .||.|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMAL
. |. |||.|..| .| .||..|.||.||. .|.. |
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0041856 (Phosphotyrosine protein) phosphatases II 292-524 2.3e-36 120.4 In-house 1-170 (182) alignment 
Range on Protein: 292-524
Range on HMM: 1-170/182.0
NQNKNRDMEYLPCELNSsrvvlfstkkEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNtleetgqtYTEYWPtehpeiygsv
|..||| ...||.. .             |||||.. . .   . ||.||.|. .|. .|.||. ... .|||.|.           |||          
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywp..........

lveplsndnygdftmrrlkvssytEQSHVIVRHFSYFNWPDKSGPAnYQSALELMSEVQRsqqqaKNRPIIVQCSNGTTRSGAFCAIYSILERlkieQvV
                        |  .  . .. |..||| . |   ...|... ||..     ...|..| || |  |.|...|.| ....    . |
........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.v

DVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRY
......| .| .||..|... ||. .. ..| .
sleeavklvrsrRpgmvitpnqyfflqlallel
subfamily_CG42327_pd Subfamily CG42327 292-452 1e-16 55.5 In-house 28-193 (319) alignment 
Range on Protein: 292-452
Range on HMM: 28-193/319.0
NQNKNRDMEYLPCELNSSRVVLFSTKKEADYINASFADAYKER-DLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETG-QTYTEYWPTEH----P
 ..|.| .. .|    .  .   . ...  |..||.   |..    .| .|... ... .|||.| . .. .|| |  | | | .  .||.||.      
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

EIYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQSHVIVRHFSYfNWPDKSGPANYQSALELMSEVQRS
. || .||    ..    . .  | .    ..    . |. | .|..   ||. .. . .. ||. |
slyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 293-519 6.6e-35 115.4 In-house 4-233 (237) alignment 
Range on Protein: 293-519
Range on HMM: 4-233/237.0
QNKNRDMEYLpcELNSSRVVLFSTKKEADYINASFADAYKE-RDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQ-TYTEYWP-TEHPEIYG
. |||  .      . |||||  .  ..|||||.. . .      .| .| |.  .  .||.|| | |   ||||  | |  .    .||| |. |. ||
kiknrygniv..aydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

SVLVEPLSNDNYGDFTMRRLKVSSYTEQSHV-IVRHFSYFNWPDKSGPANYQSALELMSE-VQRSQQQAKNRPIIVQCSNGTTRSGAFCAIYSILERLKI
 . |    .... |.|.| | .|  ... .| ..  . .  |||.  | .  . | .  . ..||.  ..  | |. || |  |.| |  | ..| . | 
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqake

EQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYE
..|||... .. |   ||  . .  |||  ..
kkvvdiynyvysieedrpyiiqtkdqyvfihq
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 304-525 2.3e-22 73.8 In-house 60-285 (302) alignment 
Range on Protein: 304-525
Range on HMM: 60-285/302.0
CELNSSRVVLFsTKKEADYINASFADAYKERDLFIMTQAPMTQTT---VEFWRMVMQYKAGTIVMLNTLEETGQTYTEYWP--TEHPEIYGSVLVEPLSN
...  |..|   .... .|.|||  .  . .   |..| | ....    ||||||.| |  ..|.|   ||  .|  |..|  ..  . ||.. |     
vpildsnlvkl.eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkV

DNYGDFT-MRRLKVS--SYTEQSHVIVRHFSyfNWPDKSGPANYQSALELMSEVQRSQQQAkNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQ
..  . . .  . |    ...   . | ...  ||..|..| .| .. . . .|  ....| . ....   ||. | ||| .    .|.|. .. . . .
ekaeeektryviEvlPegcsnsvlanvyvlt..nWkqkkvpvkyaeliktaakvfakkika.dentvivSknGaGRagafltlavaveklqkgkepnike

VIKVIRIKRPQSVTSLAQYVSCYEMALRYL
..| || .||..| || |||| | ..| |.
ivksiRsqRpravdslkQyvslyialllyi
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 306-525 7.8e-21 69.3 In-house 47-270 (285) alignment 
Range on Protein: 306-525
Range on HMM: 47-270/285.0
LNSSRVVLfsTKKEADYINASFAD-AYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQT-YTEYWPTEHPEI-----YGSVLVEPLsN
.. .||||   ... ||| ||.     |..  .| || |. .|  .||.|. | |   ..|| || | |    . |.| .  |.     |   | |   .
ieetrvvl..knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteck.e

DNYGDFTMRRLKVSSYTEQ--SHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSqqQAKNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQV
.      .  | |    .     . . |     |||.  | . .  .||   |..   . |..|| |.|| |  |. .|  |     |.  .  ......
eaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv..npkekpicvhcsagvgrtatfvgidyatirimenpniemldi

IKVIRIKRPQSVTSLAQYVSCYEMALRYL
.. .|  | |.| |  |..  | . . |.
vremramrfqavqshmqflflyvvlmeyf
subfamily_PTPRD_pd Subfamily PTPRD 307-529 7.4e-74 244.4 In-house 61-285 (564) alignment 
Range on Protein: 307-529
Range on HMM: 61-285/564.0
NSSRVVLF--STKKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQ-TYTEYWPTEHPEIYGSVLVEPLSNDNYGD
..|||||     ... ||||||| |.|..|  .| ||.|. .|. .|||||....  |||||. ||| |.  . .|||....| ||.. |.. .. .. |
dhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeelad

FTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQqQAKNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIK
...| .|..  ....   ||.| . .|||.  | . .| |.|...|.... . .. ||.|.||.|  |.|.|..| ..|||.| |..||..|..| .| .
yeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkq

RPQSVTSLAQYVSCYEMALRYLDTFG
|.  | .  ||. ..|. | .|. . 
RnamVqteeQYiFiheailealacgn
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 307-514 6.4e-18 59.9 In-house 31-248 (290) alignment 
Range on Protein: 307-514
Range on HMM: 31-248/290.0
NSSRVVLFSTKK--EADYINASFADaYKERDLFIMTQAPMTQT------TV-EFWRMVMQYKAGTIVMLNTLEETGQT-----YTEYWPTEHPEI--YGS
. .||||   .|    ||| |..   . .   .|.||.| ...      |. .|| |..| |.  .|||   ||  .       ..| |..  |.  .. 
eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg

VLVEPLSNDNYGDFTMRRLKVSsYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQrsqqqAKNRPIIVQCSNGTTRSGAFCAIYSILERLK-IEQ
. |.  |  .  |. .|.| |  . .. .  | |  . .| . . . . ...|.|.. |.     |.. |.|| | .|  || |. ||      .   ..
ltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiilgyQkiaetsg

VVDVFQVIKVIRIKRPQSVTSLAQY
 | . .|.|..| .| . .||  ..
svkledvlkalrkqralaitsalel
0044763 (Phosphotyrosine protein) phosphatases II 314-524 7.4e-23 76.5 In-house 12-170 (178) alignment 
Range on Protein: 314-524
Range on HMM: 12-170/178.0
FSTKKEADYINASFADAYkerdLFIMTQAPmtqttVEFWRMVMQYKAGTIVMLNTLEETG-QTYTEYWPTEHPeiygsvlveplsndnygdftmrrlkvs
..    .||||||. . .    |..... |     ....... ... ..||.|..  | | . . .|||.|.                            
leglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...........................

syteqshvivRHFSYFNWPDKSGPANYQSALELMSEVQRSQQqAKNRPIIVQCSNGTTRSGAFCAIYSILERlkieQVvDVFQVIKVIRIKRPqSVTSLA
           .. ....|| . |  ..  ||..  ... ..  |..|..| || |  |||...|.| ....    .. .....|. .| .||  |..  
..........iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpg

QYVSCYEMALRY
|.  .||..||.
qlrqLyefelrl
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 317-531 1.9e-20 67.8 In-house 64-282 (312) alignment 
Range on Protein: 317-531
Range on HMM: 64-282/312.0
KKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQTYT--------EYWPTEHPEIYGSVLVEP-LSNDNYGDFTMR
  |  || | |       . |. ||.|. .|.. ||....   . .|..| .. | |   .         .   |   .|     |  .        | |
gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithr

RLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQqqaknRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQS
 |||   .      . |. .  |||.  |   ..|| |.| |.. .     .|.| .|| |  |.|... | |..  |.  .  .| ..  ..|  | .|
vlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk.....kpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrars

VTSLAQYVSCYEMALRYLDTFGDY
|  ..||| .    | .| . | |
vrvfpqyvyalrcvleflyskgly
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 317-434 1.4e-13 45.3 In-house 10-125 (130) alignment 
Range on Protein: 317-434
Range on HMM: 10-125/130.0
KKEADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETgqtyTEYWPTEHP-EIYG-SVLVEPLSNDNYGDFTMRRLKVSSY
 .. .||||||         ...||.|...|...||.|...     .|.| ..||      ||||   | | |   ..|     |..       |...| 
lqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee....deywpdsePlewyeediivtltdrdefknikasnleiesd

TEQSHVIVRHFSYFNWPDKS
  .||  .  |   |||   
lneshqaltmfqisnwpsdg
0043147 (Phosphotyrosine protein) phosphatases II 319-520 1.3e-33 111.6 In-house 4-156 (172) alignment 
Range on Protein: 319-520
Range on HMM: 4-156/172.0
EADYINASFADAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLeetgqtyteywptehpeiygsvlveplsndnygdftmrrlkvSSYTEQS
  ||||||. | |   | ||.||.|.  |. .||||. ... ..||.|..|                                            ..|. 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpell

HVIVRHFSYFNWPDKSGPaNYQSALELMSEVQRSQQQAKNRPIIVQCSNGTTRSGAFCAIYSILerlkieQVVDVFQVIKVIRIKRPQSVTSLAQYVSCY
.  . .. |..||| . | . .  ||... ... ... .. |..| || |  |.|...|.| .|      . ........ .| |||..|..  ||  .|
erlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfly

EM
. 
yf
0051429 (Phosphotyrosine protein) phosphatases II 320-528 8.1e-38 126.0 In-house 4-228 (272) alignment 
Range on Protein: 320-528
Range on HMM: 4-228/272.0
ADYINASFADAYKE---RDLFIMTQAPMTQTTVEFWRMvMQYKAGTIVMLNTLEETGQTY-TEYWP------------TEHPEIYGSVLVEPLSNDNYGD
 .||||.. . |     ..... ...|.. |  .|||.  ...  |||.| ..|| |.     |||            .. .  || . |  ||  .. |
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

FTMRRLKVSSY-TEQSHVIVRHFSYFNWPDKSGPANYqsALELMSEVQRsqqqakNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVD--------VF
...|.| .. . . .    |.|. | .||| . | ..   |||......      ..|..| || |  |.| ..|.. .|...  |..||        ..
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

QVIKVIRIKRPQSVTSLAQYVSCYEMALRYLDTF
.... .| .||..| . .||. .|| .| .|...
eaveelraqrpgavqteeqylflyeallellrsl
0046846 (Phosphotyrosine protein) phosphatases II 320-525 1.5e-31 104.9 In-house 12-173 (176) alignment 
Range on Protein: 320-525
Range on HMM: 12-173/176.0
ADYINASFADAYKerdlFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQTY-TEYWPTEHPEIYgsvlveplsndnygdftmrrlkvssyteqs
 |||||.... ..    .| ||.|. .|. .|..|. ... ...|.|... |.|.   . ||| .. . .                              
ldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..............................

hvivrHFSYFNWPDKSGPANyQSALELMSEVQRSQQQAknRPIIVQCSNGTTRSGAFCAIYsileRLKIEQVVDVFQVIKVIRIKRP-QSVTSLAQYVSC
     .. ...||| . |   .  |||. .... ...   .|..| || |  |.|...|.|     |. |. ..|..... .| .|| ..|.. .||  .
.....qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrfl

YEMALRYL
||..|..|
yefellll
0036282 (Phosphotyrosine protein) phosphatases II 321-520 5.9e-36 119.1 In-house 3-165 (174) alignment 
Range on Protein: 321-520
Range on HMM: 3-165/174.0
DYINASFADAYKERDLFIMTQAPMTqttveFWRMVMQYKAGTIVMLNTLEETG-QTYTEYWPTehpeiygsvlveplsndnygdftmrrlkvssYTEQSH
||||||. | .   . .| .|.|..     ||.|. ...  |.|||....| |      |||.                               . |  .
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredle

VIVRHFSYFNWPDKSGPANYQsALELMSEVQRSQQQAKNRPIIVQCSNGTTRSGAFCAIYSILERLKiEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYE
  . .. |..||| . |   .  ||....|.. ... ...|..| || |  |.|...|.| .| .|. | .||...... .| .||..|..  ||  .|.
rlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy

M
.
f
0051082 (Phosphotyrosine protein) phosphatases II 321-519 1.3e-26 88.4 In-house 4-147 (151) alignment 
Range on Protein: 321-519
Range on HMM: 4-147/151.0
DYINASFADAYkerdlFIMTQAPMTqttvEFWRMVMQYKAGTIVMLNTLEETGqTYTEYWPTEHpeiygsvlveplsndnygdftmrrlkvssyteqshV
||||.|. . .     .. ...|.     .|.... ...  |||.|...||.| ...||.| .                                    .
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg...................................i

IVRHFSYFNWPDKSGPANYQSALELMSEVQRsqqqAKNRPIIVQCSNGTTRSGAFCAIYSILERlkieqvVDVFQVIKVIRIKRPQSVTSLAQYVSCYE
 |.|. ...||| . | .....||.......     || |..| || |  |.|...|.| .|..      |....... .|.||| .|..  |.. .. 
evlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 329-520 1.8e-30 100.7 In-house 230-433 (440) alignment 
Range on Protein: 329-520
Range on HMM: 230-433/440.0
DAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEEtgQTYTEYWPTEHPeiygSVLVEPLSNDNYGDFTMRRLKVS----SYTEQSHVIvRH
. |  .. || || |.  | ..|||.| .|.  ||.||| |..  .| . ||| .      ||   |..    |   | |.||      | |. | | | 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd..ktcsiywpvntr....svtfgpftvghkgsenmnrvkvrtlelkykeevhei.rq

FSYFNWPDKSGPANY-------QSALELM-----SEVQRSQQQAK---NRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVT
|    ||               .. |.||      |.||| .|..     ||.|.|  |   || ||..   ||.|. .  .|||| ....|. ||. | 
fevqtwptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvp

SLAQYVSCYEM
.|..|. || .
tltdyllcykl
0049260 (Phosphotyrosine protein) phosphatases II 329-519 8.7e-30 98.8 In-house 3-144 (152) alignment 
Range on Protein: 329-519
Range on HMM: 3-144/152.0
DAYKERDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQTYTEYWPtehpeiygsvlveplsndnygdftmrrlkvssyteqshvivrHFSYF
| |.    || ||.|. .|. .||||. .....|||||..|.| |  ..|...                                          .. ..
dgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhl

NWPDKSGPANYQSALELMSEVQRSqQQAKNRPIIVQCSNGTTRSGAFCAIYSILerlkieQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYE
.||| . | . |  |.|.  ...  .. |. |..| || |  |.|...|.| .|      . |....... .| |||..|..  |.  .||
pwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 334-519 3.5e-21 70.3 In-house 4-198 (199) alignment 
Range on Protein: 334-519
Range on HMM: 4-198/199.0
RDLFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQ-TYTEYWPTEHP--EIYGSVLVEPLSNDNYGDFTMRRLKVSSYT--EQSHVIVRHFSYF
.  .| || |. .|  .||.|| .  .| |||.|  .   .  |  |||| .     |||. |   .     |.|.  | ... |    |   . |. . 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

NWPDKSGP--ANYQSALELMSEVQRSQQQAKNRPIIVQCSNGTTRSGAFCAIYsILERLKI---EQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYE
 | .|. |  | .   .    || .  .| |. |.||.||.|   .| | |.  |  | .      |||.|.| | .|  |   ..|| .|   |.
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvald.igvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_hpo-7_pd Subfamily hpo-7 335-510 2.6e-15 51.0 In-house 38-212 (263) alignment 
Range on Protein: 335-510
Range on HMM: 38-212/263.0
DLFIMtqapMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQ-TYTEYWPTEHPEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTE--QSHVIVRHFSYFNWP
.|...    . ||  .|.... | |. ..|||   .| |.    .|.|.|. |      |.  . .   |  .. |.. |. .  .    |.|.||  |.
nlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWi

DKSGPANYQSALELMSEVQRSqqqaknRPIIVQCSNGTTRSGAFCAIYSILE----RLKIEQVV--DVFQVIKVIRIKRPQSVTS
.| .| . .. |...  .. |      ....| ||.|  || ||  . ..       |.  . |  |  .... .| .|....  
ekndpelareilnilkvarns......kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraiht
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 336-519 4.1e-21 70.1 In-house 5-197 (198) alignment 
Range on Protein: 336-519
Range on HMM: 5-197/198.0
LFIMTQAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETGQ-TYTEYWPTEHP--EIYGSVLVEPLSNDNYGDFTMRRLKVSSYT--EQSHVIVRHFSYFNW
 .| || |. .|  .||.|| .  .| |||.|  .   .  |  |||| .     |||. |   .     |.|.  | ... |    |   . |. .  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDKSGP--ANYQSALELMSEVQRSQQQAKNRPIIVQCSNGTTRSGAFCAIYsILERLKI---EQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYE
 .|. |  | .   .    || .  .| |. |.||.||.|   .| | |.  |  | .      |||.|.| | .|  |   ..|| .|   |.
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvald.igvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 339-514 4.1e-17 57.1 In-house 39-210 (255) alignment 
Range on Protein: 339-514
Range on HMM: 39-210/255.0
MtqapmtqTTVEFWRMVMQYKAGTIVMLNTLEETG-QTYTEYWPTEHPEIYGSVLVEPLSNDNYGDFTMRRLKVSSYTE--QSHVIVRHFSYFNWPDKSG
.       |  .|.....| |. ..|||  ..| | .   .|.|.|. |      |.  . ..  |  .| |.. |.    .    |.|.||  |..| .
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna

PANYQSALELMSEVQRSqqqaknRPIIVQCSNGTTRSGAFCAIYSILE----RLKIEQVV--DVFQVIKVIRIKRPQSVTSLAQY
| . .  |...  |. |      ....|.||.|  || ||  . ..       |.  . |  |  .... .| ||....    | 
Pelareilnilkvvrds......ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlql
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 341-513 1.8e-10 34.8 In-house 97-276 (302) alignment 
Range on Protein: 341-513
Range on HMM: 97-276/302.0
QAPMTQTTVEFWRMVMQYKAGTIVMLNTLEETG-QTYTEYWPTEHPEI--YGSVLVEPLS-NDNYGDFT------MRRLKVSSY--TEQSHVIVRHFSYF
  |  .|.  .| .. ||. . .| | .. | . . ..||. ..  .   .|   |. .| ...  .||      .  ...  .  ... .  |  . . 
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

NWPDKSGPANYQSALELMSEVQRSQqqaKNrpIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQ
 |||.  |.. ..||...   .  .   ||  ..| ||.|  |.|.. ||   ..  . ..| |. .... .|  |  .| .  |
awpdhGapkeaytaldilkfcesyk...kn..vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 348-525 8.7e-10 31.7 In-house 131-309 (346) alignment 
Range on Protein: 348-525
Range on HMM: 131-309/346.0
TVEFWRMVMQYKAGTIVMLNTLEETGQTYTEYWPTEHPE--IYGSVLVEPLSNDNYGDFTMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALEL
  .|| |. | .   . ..   .   .| |  .  |       | ....    |  ||     ..|    .   ||..   .  |     | .    . .
vedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlpiikm

MSEVqRSQQQAKNRPIIVQCSNGTTRSGAFC-AIYSIlERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRYL
. .   |..| .|  . |    |. |. .|  |.|.| ..|      ......| |. .|| .| |.||| | | . . |.
ihqf.lsekqvqnagvcvvslfgcgracsfigalyai.nqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
0048179 (Phosphotyrosine protein) phosphatases II 405-519 9.9e-17 56.5 In-house 32-139 (144) alignment 
Range on Protein: 405-519
Range on HMM: 32-139/144.0
TMRRLKVSSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQqaKNRPIIVQCSNGTTRSGAFCAIYSILerlkIEQvVDVFQVIKVIRIKR
|  .|  . . |   . . .. ...||| . |  ..  ||..  ... ..  ...|..| || |  |.|...|.| ..     .. ........ .| .|
tvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrr

PQSVTSLAQYVSCYE
|..|..  |.  ..|
pgavpnpgqlrfLle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 411-524 2.1e-10 34.9 In-house 211-343 (350) alignment 
Range on Protein: 411-524
Range on HMM: 211-343/350.0
VSSyteqsHVIVRHFSYFNWPDKSGPANYQSALELMS--------E-VQRSQQQAKNRPIIVQCSNGTTRSGAFCAIYSILER-----------LKIEQ-
.|        .| .. . ||.| |   | .| |. .            .   ..|.  ||.| || |  | | .... |.|.             |... 
asd.....PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldva

--VVD-VFQVIKVIRIKRPQSVTSLAQYVSCYEMALRY
  . | ...... .| .| . | .| |.. .|| .| |
aktrDlisiivnelrkqrismvqnldqfifiYeallfy
0048076 (Phosphotyrosine protein) phosphatases II 412-524 4.1e-17 57.7 In-house 37-142 (145) alignment 
Range on Protein: 412-524
Range on HMM: 37-142/145.0
SSYTEQSHVIVRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQakNRPIIVQCSNGTTRSGAFCAIYSILErlkiEQvVDVFQVIKVIRIKRPQSVTSL
.|..|     . .. |..||| . |  ..  ||..  ... ...  ..|..| || |  |.|...|.| .|.    .. |....... .| .||..|.. 
tselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnp

AQYVSCYEMALRY
 |.  .||  |..
gqlrflyefelel
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 416-525 2e-07 24.7 In-house 214-344 (349) alignment 
Range on Protein: 416-525
Range on HMM: 214-344/349.0
EQSHVIVRHFSYFNWPDKSGPANYQSALELM---SEV------QRSQQQAKNRPIIVQCSNGTTRSGAFCAIYSILE--------RLKIEQVV---D-VF
...  ..  . . ||.| |   | .| |. .   ...      .   ....  ...| || |  |.| .. . ..|.          ||.      | ..
vekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlis

QVIKVIRIKRPQSVTSLAQYVSCYEMALRYL
 ..  .| .| . |  |||.. .||  |.|.
iivnelrkqrismvqnlaqfiaiyealLkyf
PTPc_DSPc_SM00012 422-522 1.5e-27 91.2 In-house 2-104 (105) alignment 
Range on Protein: 422-522
Range on HMM: 2-104/105.0
VRHFSYFNWPDKSGPANYQSALELMSEVQRSQQQAK-NRPIIVQCSNGTTRSGAFCAIYSILERLKIE-QVVDVFQVIKVIRIKRPQSVTSLAQYVSCYE
|.|. | .|||.. | . .| |||. .|........ . |..|.||.|  |.| |.|.. .|..|. | . ||.||..| .| .||..|....||. .|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

MAL
. |
all
subfamily_CG42327_pd Subfamily CG42327 450-524 1e-09 32.5 In-house 239-314 (319) alignment 
Range on Protein: 450-524
Range on HMM: 239-314/319.0
QRSQQQAKNRPIIVQCSNGTTRSGAFCAIYSILERLKIE-QVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRY
 || .. .. |..| ||.|. |.|   |    ...|.   . ||. |..  .|  | ..| .  ||   | ..  |
srsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 455-524 1.2e-09 32.5 In-house 225-294 (297) alignment 
Range on Protein: 455-524
Range on HMM: 225-294/297.0
QAKNRPIIVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVSCYEMALRY
. .| ...| || |  |||       ||..|. ... ||  .....| .|.. | .| |.  .|...|. 
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 462-516 3.2e-10 34.2 In-house 2-56 (69) alignment 
Range on Protein: 462-516
Range on HMM: 2-56/69.0
IVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYVS
.|.|| || |.|.| ||   . |.| |..||.|  .. .|  ||  |    .|. 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyif
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 462-515 1.3e-09 32.3 In-house 1-54 (69) alignment 
Range on Protein: 462-515
Range on HMM: 1-54/69.0
IVQCSNGTTRSGAFCAIYSILERLKIEQVVDVFQVIKVIRIKRPQSVTSLAQYV
.|.|| || |.|.| ||   . |.| |..||.|  .. .|  ||  |    .|.
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneym