Gene NvecPTP-sf2-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP045_AA protein Get Run
NvecP045_AA_1-242 phosphatase_domain Get Run
NvecP045_AA_254-532 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1-249 3.5e-128 422.0 In-house 49-298 (298) alignment
Range on Protein: 1-249
Range on HMM: 49-298/298.0
EAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPrSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD
|.||||.||.|||||.|.|.|.||||||....||.||||||||.|.|.|.. .|||.|.||....|.|||||.|.....|||||||.||.|||.||||||
evarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPd

-KTETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAlNPRDAG--PVIVHCSAGVGRTGAYIVIDAM
 ..|||| .||.|...| |||...|....||.|....|.|||.|||.|||||||..||.||...||||| ....||  ||||.|||||||.|..|.||..
egketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsv

LEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQ
||..||...||.......|||.||..|||.|||.||..||||||...|.||.
lervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndeie

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1-239 5.3e-104 341.6 In-house 1-239 (239) alignment
Range on Protein: 1-239
Range on HMM: 1-239/239.0
EAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD
|||.|  || ||||||||.|||||||||... |  |||||||... |||.|...||.|| . ..   ||||.|..    ||||| |.|  | |||.||||
eaakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

KTETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQ
 |  |  . |||...|.|||| ||||..|.  ..  | | |.|||||||||||||||||| .|||.   .   | | ..|||||||||||..|||||| |
stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
||| .|||| ||. |.|.|||||||| ||| ||| ||||
akkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_PTPRA_pd Subfamily PTPRA 1-275 6.6e-96 316.0 In-house 51-329 (330) alignment
Range on Protein: 1-275
Range on HMM: 51-329/330.0
EAARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD
|.| |  ||.|||. ||. ||.|||.|  ..| |.|||||||||.||     .|||.|||.  . | ||||.|||.|..|||||.| |  ..||..||||
elaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykek.dkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd

K-TETYGGVTVTLHQSEIFADYEIRTFILS----KAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVID
. . ||| ..|.......  || .| |..     ....  ||.||||||| ||| |||  .  .| . .||..||.. |||..|||||||||||..||.|
eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivld

AMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLASVNRKFQMTGYALE
|.||. |  | ||. . .  ||. ||.||||.||| ||. ..||    |.||..    .. .||| .   ... .|   |
avlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynkitgtdkigleee

subfamily_PTPRD_pd Subfamily PTPRD 2-427 8.5e-218 719.5 In-house 42-466 (564) alignment
Range on Protein: 2-427
Range on HMM: 42-466/564.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
||.|||||.|||||||||||||||||..|.|||.|||||||||.||. .....||.||||....| ||||||||||..|||||.|.| ||.|||||||.|
aankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek

-TETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQ
 |||||..||||...| .||||||||.|.|.|.| ||.||||||| |||.|||..||..|...|||||||..||||..|||||||||||..||||||||.
gtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamler

AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLASVNRKFQMTGYALEFQRLNsvTSREIPAEEKSVGEKPQN
.|...||||..|..||||.|..||||.|||.|||.|.||||.|||||..|||..|..||||.|.....|||..||||||.  |..||..||..|..||.|
ikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeveedtemtgleleFqrLa..takeieleefavatkpkn

LHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHE-HDQEYPQYLPVEGATKYGHI
..|||||.|.||.||||.|....|.||||||||..|.   |..||||||.||..|.|||||||.......||||..|.|  ..|. .| .  .|||||.|
kkknrfsnilalescrvvlsairakeesdyinasyleayrekrafiatqaplkntvedfwrmvweeevkiivmltkleekleeesseyysdleatkyGei

RVSLLSKQEKGDVISTKLKVTRNKKTHE
 ...|.|.||.|.. .| ||....|...
tikvlkkkeksdilfrkkkvevkeksea

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2-254 3.7e-126 414.4 In-house 3-249 (250) alignment
Range on Protein: 2-254
Range on HMM: 3-249/250.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTkCHKYWP-D
 |.||.||.|||||.|.|.|.||||||...||..||||||||.||||.. ..|||.||||....|.|||||.|..|..|||||||.| .|| .|.||| .
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

KTETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR-DAGPVIVHCSAGVGRTGAYIVIDAMLE
|.|.||.|||.|...|.||||..|...|||||....|.|||.||.||||||||..|||||....||.| ... ...||||.|||||||.||.|.|||.||
kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCgnteiqSENYN
..||...||.......|||||||.|...|||.|.....|.||..      .|.|.
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds......vedya

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2-240 5.5e-104 341.5 In-house 1-239 (239) alignment
Range on Protein: 2-240
Range on HMM: 1-239/239.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
||.|  || ||||||||.|||||||||... |  |||||||... |||.|...||.|| . ..   ||||.|..    ||||| |.|  | |||.|||| 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

TETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQA
|  |  . |||...|.|||| ||||..|.  ..  | | |.|||||||||||||||||| .|||.   .   | | ..|||||||||||..|||||| ||
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
|| .|||| ||. |.|.|||||||| ||| ||| |||||
kkqktvdifnyvkairedrphmvqtseqyvfihlavlea

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2-277 5.1e-101 332.9 In-house 42-319 (319) alignment
Range on Protein: 2-277
Range on HMM: 42-319/319.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
 | |. ||.|||| ||.|||..||||  ..| |.||||||||| ||.   . ||| |.||  ..| |||||||..|  .||||.||| .| |..||||..
saskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqer.ekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpee

T-ETYGGVTVTLHQSEIFADYEIRTFILSKAKRSG-SRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR-DAGPVIVHCSAGVGRTGAYIVIDAML
. |.|| ..||| . |  .||.|| . | |..    .|.| .|..| |||..||..||..|.. ...|    . ..||..|||||||||||..||.||||
nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldaml

EQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLASVNRKFQMTGYALEFQ
|. |.  ..|. ..   ||  |. |||..|||.||. |.|||...|.|||. .. .. ...||. . .  .|| . |||
ervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtgetglerefq

0050432 (Phosphotyrosine protein) phosphatases II 2-245 5.2e-96 316.9 In-house 62-303 (308) alignment
Range on Protein: 2-245
Range on HMM: 62-303/308.0
AARKPANKNKNRYANIVAYDHSRVVLervngDEDSDYINASFIHGYD-GTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD
.|..|.||.|||| .|..||||||.|     ||.|||||||...||. . || ||| |||||  .| |||||||||.. |||||.||| |. ||..|||.
vallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwpl

----KTETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNprDAGPVIVHCSAGVGRTGAYIVIDA
    ....||..||||   |...|| .||..|.. . . ||.|..||.| ||| |||......|.| ..||  .  . ||..|||||||||||..|..| 
elgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdl

MLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
.||| .| ..||. ...  ||. ||.||||.||| |.. |.|| | .  
lleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl

subfamily_PTPRG_pd Subfamily PTPRG 2-255 5.3e-96 317.0 In-house 41-301 (563) alignment
Range on Protein: 2-255
Range on HMM: 41-301/563.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDS-DYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-
...|| ||.|||| ||||||.||| |. . | ... |||||..|.||    . |||.||||.  |. ||||.||||.. |||.||||| |. ||. ||| 
hsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk

DKTETYGGVTVTLHQSEIFADYEIRTFILSK--AK----RSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIV
|..|||| ..||| ..|..| | .||... .   |    .   ..|||.|.| |||.|||.... || | .|  | |...|||..||||||||||| |||
desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyiv

IDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQ
.|..|.| ..  .|.. . |  .|  |...|||.||| |.| |.|||.. ..||...|. ..
ldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqvee

subfamily_PTPRB_pd Subfamily PTPRB 2-244 5.3e-95 312.8 In-house 45-288 (293) alignment
Range on Protein: 2-244
Range on HMM: 45-288/293.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
||....|..|||| ||..|||||| |. ......||||||..|.||  .|| |||.||||| ... |||||||..|. |||||.||| ||.||..|||..
aaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyn.sprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad

--TETYGGVTVTLHQSEIFADYEIRTFILSKakRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALN--PRDAGPVIVHCSAGVGRTGAYIVIDAM
  . .|| ..||| ..|   |. ||.. ..|  .. .| |||.||| ||| |||. ....|.| |.||       ...|..|||||||||||..| .| .
eepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrl

LEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCG
|.. ... .|||   ...||..| ..|||..|| |||..||. |. .
lqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk

subfamily_PTPRK_pd Subfamily PTPRK 2-260 9.5e-95 312.0 In-house 37-296 (314) alignment
Range on Protein: 2-260
Range on HMM: 37-296/314.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
||.|  |..|||. .|.|||.|||.|  ..|| .||||||..| .|   |. ||. ||||.   . |||.|...|. ||||||.||| |. || ||||..
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

TETYGGVTVTLHQSEIFADYEIRTFILSKA--KRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLE
||.|| . |.| ..|. |.. .|.| ..|.  . .. |.||||.|. ||| .||..||..|.. |.| . .. .||...|||||| ||||..|.|| .|.
tevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivld

QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKL
 ... ..||. |   .||. .. ||.|.||| ||. ..|||  ||.| |   ... .  . 
mieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyles

0051299 (Phosphotyrosine protein) phosphatases II 2-241 1.8e-94 311.7 In-house 43-286 (288) alignment
Range on Protein: 2-241
Range on HMM: 43-286/288.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-D
||..|.|..|||| .|..||||||.|  ..|.|.|||||||.|.||. . . ||| |||||  .| |||||||||.. |||||.|||||..||..||| .
aallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplg

KTETYGGVTVTLHQSEIFADYEIRTFILSKA----KRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDA
...||| .||||   |...|| .||.....     . . ||.|..||.| ||| |||......|.| |.||  .. . |||.|||||||||||..|..| 
gsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdl

MLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
.||| .| ..||. ...  ||. ||.|||| ||| |.. |.||.|
lleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0046845 (Phosphotyrosine protein) phosphatases II 2-246 2.5e-92 304.6 In-house 22-279 (284) alignment
Range on Protein: 2-246
Range on HMM: 22-279/284.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGD-EDSDYINASFIHGYD----GTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHK
.|..|.|..|||| .|..||||||.| ...|| |||||||||...|||     ... ||| |||||  .| |||||||||.. |||||.||| |..||..
vallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaq

YWPDK--TETYGGVTVTLHQSEIFADYEIRTFILSKAK-RSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP--RDAGPVIVHCSAGVGRTGAY
|||..  . |||..||||   |.. || .||. |.. .  . ||.|..||.| ||| |||.... .|.| |.|| |..   . ||..|||||||||||..
YwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtf

IVIDAMLEQAKKSR---TVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNT
|..| .||| .| .   .||. ...  ||. ||.|||| ||| |.. |.||.| ...|
ialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt

0036941 (Phosphotyrosine protein) phosphatases II 2-249 4e-91 300.7 In-house 33-285 (297) alignment
Range on Protein: 2-249
Range on HMM: 33-285/297.0
AARKPANKNKNRYANIVAYDHSRVVLervnGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP--
.|..|.|..|||| .|..|||.||.|    .||.|||||||.. ||| . . ||| |||||  .| |||||||||...|||||.|||||. ||..|||  
vallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywple

-DKTETYGGVTVTLHQSEI--FADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVGRTGAYIVI
 ... |||..||||   |.  ..|| .||. ... . . ||.|..||.| ||| |||.... .|.| ..||  ..   . |||.|||||||||.|..|..
egesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaa

DAMLEQAK---KSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQ
| ||.| .   | ..||| ...  ||. ||..||| ||| |.. |.|| | ...| ..
dlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkep

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2-261 1.5e-90 298.3 In-house 43-299 (315) alignment
Range on Protein: 2-261
Range on HMM: 43-299/315.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
 |.|  ||.|||| ||.|||.||| |  .. |..|||.||.|| ||.  .| .||.|||.. . . |||.|.|..   |||||||||  | |. ||||||
vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk

TETYGGVTVTLHQSEIFADYEIRTFilSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQA
  .|| .|||. . |.. .| .||.  |   ..  | | |.|.| ||| |||.|..... . |.|.  .  ..|...|||||||||||..| .||.|.||
kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqa

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLA
.  . .|. |..  .|. | .|||. ||| ||..|.||.. ||.| |  . | |  . | 
eaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsll

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2-242 2.6e-88 290.8 In-house 35-277 (281) alignment
Range on Protein: 2-242
Range on HMM: 35-277/281.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
|.....|..|||| ||||||..||.... . ....|||||.|. ||.| .. .||.|||.| ... ||.|||||. . |||.|. .| || |||.||||.
askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykg.ekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPdd

T--ETYGGVTVTLHQSEIFADYEIRTFILsKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKV-RALNPRDAGPVIVHCSAGVGRTGAYIVIDAML
.   .|| |||. ...|  | |  |.| | ... . .| |.|...| |||.|||. ....| ||..| .. ...   |...||||||||||.|| .| ..
nselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlv

EQAK-KSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALT
.... . ...|... .  |||.|  ||||  ||.|.. |||.|| 
kaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2-240 2.6e-86 284.2 In-house 41-278 (288) alignment
Range on Protein: 2-240
Range on HMM: 41-278/288.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
|.|.. |..|||| ||..||. || |. ..  ...||||||.|.|.... . .||.||||. . . ||..|.|.... |||||.||| |||||..||||.
agrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkk.kkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPda

TE--TYGGVTVTLHQSEIFADYEIRTFILSkaKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLE
 .   || ||||| .|.   |.  |...|   |. . . . |.....|||.|||. .. .|...|.|   |. |.||.|||||||||||| .|..||...
dkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalid

QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
. ... ..|. . .  ||| |. .|||..|| ||....|. 
aveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl

0045450 (Phosphotyrosine protein) phosphatases II 2-241 2.1e-85 282.4 In-house 49-304 (307) alignment
Range on Protein: 2-241
Range on HMM: 49-304/307.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGD-EDSDYINASFI--------HGYDGtPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKT
.|..|.||.|||| .|..|||.||.|  ..|. |||||||||..        .|||  .| ||| |||||  .| ||||.|||... |||||.|||||. 
iallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgre

KCHKYWPDK--TETYGGVTVTLHQSEIFADYEIRTFILSKA-KRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVGR
||..||||.  . ||| .||||   |. ..| .||. ..   . . ||.|..||.| ||| |||..   .|.| ..||. . .  . |||.|||||||||
kcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgR

TGAYIVIDAMLEQAKKSRT---VDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
||..|... ||.| .|  |   ||... .  ||. ||..||. ||| |.. |.|| |
tGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_PTPN12_pd Subfamily PTPN12 2-241 1.4e-78 258.7 In-house 34-277 (290) alignment
Range on Protein: 2-241
Range on HMM: 34-277/290.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
|..|. |..|||| .|. ||.|||.|.. ...|.||||||.||.| .|.  ..||.||||| . . ||||.||.| . .||. ..|||||.||..|||..
agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegk.leyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpee

T---ETYGGVTVTLHQSEIFA-DYEIRTFILSKAkrSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAM
.    ..| ..|||.. . .  |. |||. . .   . ||.|.|||.| |||.|||. |. .|.. ..|| |. ... |..|||||||||||. |.|| .
geeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyv

LEQ---AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
 |.    | . ..|. . .. |||.|. .|||||||.... ||.| .
rellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2-263 3e-78 257.8 In-house 38-299 (315) alignment
Range on Protein: 2-263
Range on HMM: 38-299/315.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD-
.||.. | .|||| ||. .|..||.|| .. . ||||||||.|...|   ...|||||||. . . |||||....  .|||.|.. |  | || .|||| 
varetinfkknryknilPldsarvkleviddsPdsdyinasyiksvdd.dkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr

--KTETYGGVTVTLHQSEIFADYEIRTFILSKAKRsgSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAML
  ..  .| . |.| . |  .|  .| ... |..   || | ||.|| ||||||.. ....| . ..|.| | ..  ...|||||||||||  | || ..
kadsvefGsikvellsleadtdgvarklvtrksee..srtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevv

EQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLASV
.|.|..|.||. |..  ||..||..|||.|.|.||. |||| |   || |   .. . .| | . 
aqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhts

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2-266 3.8e-75 248.0 In-house 42-313 (325) alignment
Range on Protein: 2-266
Range on HMM: 42-313/325.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMV--WEqnsQSIVMLTNLVELGKTKCHKYWP
.| ||.||.|||. |.||.|.||||||  . | .|||||||... . .    |.|.| ||. . . .||.|  |.    |.|...| ..||| .| .|||
vamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkk.dvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavywp

DK---TETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAL------NPRDAGPVIVHCSAGVGRTGA
..   . |.||. | |   | ..||  | . . ..|.  .| |.||..  |.| ||... ...... . | |.      | . ..|..|||||||||||.
kemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGv

YIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLASVNRK
.| . ..|..  .   ||| ...  |||||| ||.| .||..|. |. ||. .|||..   ...  .  |   |  
fislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpl

subfamily_PTPN9_pd Subfamily PTPN9 2-239 2.3e-74 245.1 In-house 36-288 (297) alignment
Range on Protein: 2-239
Range on HMM: 36-288/297.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP--
|....|| .||||.... ||..||||..|..|| ||||||.|. ||   ...||| ||||. ... ||||||||.   ||| | .|| |. || .|||  
asklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWple

-DKTETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRA--------LNPRDA-----GPVIVHCSAGV
 .... .| ..|.  . |   ||..|.. ....| . || |  | |. ||| |||. |...| ...|||         | ....      |..||||||.
eessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGi

GRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
||||..| .|  |.. ..  |||... .  ||. | ...|| ||| | . ||||
GrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle

subfamily_PTPN3_pd Subfamily PTPN3 2-240 3.3e-70 231.2 In-house 35-274 (280) alignment
Range on Protein: 2-240
Range on HMM: 35-274/280.0
AARKPANKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHG-YDG--TPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYW
|||||.| .|||| .|..||. || |.    ....|||||...    ..  .   .||.||||. . . ||.|||||.|. |||||.||| |..|||.||
aarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyW

PDKTE--TYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDA
|....  .||. .|......    | .| ..|.... . .|.. |. .. |||.|||. .. .| | ..||.|   .  ||.||||||.|||| .|... 
PetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlillet

MLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
 |    ... | . . .  .|  |  .|||..|| |.  |.|..
alalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv

subfamily_PTPN1_pd Subfamily PTPN1 2-248 3.1e-68 224.6 In-house 26-280 (290) alignment
Range on Protein: 2-248
Range on HMM: 26-280/290.0
AARKPANKNKNRYANIVAYDHSRVVLERvngdEDSDYINASFIHgYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
.|..|.|.|.||| ..  |||||..|||    .| ||||||...  .   ||.| .||||| . . ||.|||||.|...||| ..|| ...||..||| .
eaklpenrnlnryrdvspydhsrikler....adndyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqg

TE----TYG--GVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAL--NPRDAGPVIVHCSAGVGRTGAYIV
 |    ..    ..|.| . |.   | .|.. | . |   .| . .||.| ||| |||.  .| | |  |||      .| ||...|||||.||.|....
eeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfcl

IDAMLEQAKKSR---TVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTC--GNTEI
.|..| . .|.    .|||.. |..||| |  ..||..|  | . |.||   .  |.. .
vdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssv

subfamily_PTPRN_pd Subfamily PTPRN 2-240 7.4e-68 223.4 In-house 50-291 (297) alignment
Range on Protein: 2-240
Range on HMM: 50-291/297.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
.|... | .|||......|||||| |.. . .|.|||||||.|   |    ..||.||||.     ||.||||| .  ||.||.| | | ..|..||||.
vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpde

-TETYGGVTVTLHQSEIFA-DYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLE
 .|.|.   | |    |.. || .|.| |   . | .| | ||||  ||..|||  | ..| |||||       . |..||||.|.||||.||.|| .|.
GsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvln

QAKK-SRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
. .|  . .||   |  || .||..|.||.|. |. .|| | 
rllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2-264 4e-66 218.0 In-house 39-259 (392) alignment
Range on Protein: 2-264
Range on HMM: 39-259/392.0
AARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGktkchkywpdk
.|.|. |..|||| ||. || .||.|| ..   ||||.|||.|...|   ...|||||| . ... |||||...|  .|.|.|.| |             
vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdne.kayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........

tetyggvtvtlhqseifadyeirtfilskaKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQA
                              |    | | ||||| ||||.||......| | ..|.|   . . |.|.||||||||||  | ||... .|
..............................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvaha

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLASVN
||.| ||. |..  .|. ||.||||||||.||. |||| |   || |    . . .|.| .  
kktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlstss

subfamily_PTPN14_pd Subfamily PTPN14 2-241 7.3e-57 187.6 In-house 43-296 (300) alignment
Range on Protein: 2-241
Range on HMM: 43-296/300.0
AARKPANKNKNRYANIVAYDHSRVVLERVNgDEDSDYINASFIHGY-DGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD
.|. | |..|||. ... |...|| |   . .....||||| |.    |. ||.|..||||. . . ||.|||||. | |||||.  | ||.|..||.|.
taklpenaeknrfkdvlPyednrvelsptk.enstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPk

K-----TETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR---------DAGPVIVHCSAGVG
.     | ..|   || . ||    .  ... |     .  | |  . .| |||.|||.  .  | . ..|...  .            ||.||||||||
leskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvG

RTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
|||  |. | ...  .. ...||.. |  ||. | ..|||  || |....... |
rtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2-238 3.5e-56 185.1 In-house 32-274 (287) alignment
Range on Protein: 2-238
Range on HMM: 32-274/287.0
AARKPANKNKNRYANIVAYDHSRVVLErVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
|| . |. .|||||... .|..||.|   .|.  |||||| .. .|     .|||.|||.. .   |||.|.|..| |....|  || .. ||.||||..
aaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytdd.eafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer

TE--TYGGVTVTL-HQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKV-----RALNPRDAGPVIVHCSAGVGRTGAYIV
      || .|.|  ..    .| .|.. | ...   .|.|.|...  ||||...  | ... |  .|      | .  ..||..||...|.||.| .. 
evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGilla

IDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
. ..... ..   ||. . .| ||. |  .||.  |. ..  |. 
tlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv

0040438 (Phosphotyrosine protein) phosphatases II 3-259 1.4e-94 312.3 In-house 38-294 (317) alignment
Range on Protein: 3-259
Range on HMM: 38-294/317.0
ARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-DK
|..|.||.|||| .|. ||||||.|  ..||.||||||||...|.. ... ||| |||||  .| ||||||||....|||||.|.|||. ||..||| ..
aelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplge

TETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQA
| |||..|||| . |  |....||. ... . | ||.|..||.| ||| |||.. . .|.| ..||. .... |||.|||||||||||..|... |||| 
tltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleql

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQK
.| ..||. . .  ||. ||..||| ||| |.. |.|| |....| .   ..  ...|
ekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllk

0039614 (Phosphotyrosine protein) phosphatases II 3-245 5e-89 293.9 In-house 51-293 (297) alignment
Range on Protein: 3-245
Range on HMM: 51-293/297.0
ARKPANKNKNRYANIVAYDHSRVVLERVNG-DEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKtKCHKYWPDK
|..|.||.|||| .|..||||||.|  ..| |.||||||||.. ||| ..| |||.|||||  .| ||||||||....|||||.|||||. ||..|||..
allpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpee

TETYGGVTVTLHQSEIFADYEIRTFILSKakRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVGRTGAYIVIDAMLE
..|||..|||| . |  ..| .||. ...   . ||.|..|..| ||| |||.... .| | ..||  . .  . |||.|||||||||||..|... |||
ggtygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmle

QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
| .| ..||. . .  ||. ||..||| .|| |.. |.|| | ...
qlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl

0047943 (Phosphotyrosine protein) phosphatases II 3-241 1.4e-88 292.2 In-house 33-272 (273) alignment
Range on Protein: 3-241
Range on HMM: 33-272/273.0
ARKPANKNKNRYANIVAYDHSRVVLervnGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK-
|..|.||.|||| .|..||||||.|    ||..|||||||.. ||. ... ||| |||||  .| |||||||||.. |||||.|||||. ||..|||.. 
allpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleg

---TETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVGRTGAYIVIDA
   ..||| .||||   |...|| .||..|.. . . ||.|..||.| ||| |||.. . .| | ..||  .    . |||.|||||||||||..|..| 
gelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdl

MLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
.|.| .| ..||. ...  ||. ||.|||| ||| |.. |.|| |
lldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

0043336 (Phosphotyrosine protein) phosphatases II 3-239 6.7e-88 290.0 In-house 40-275 (278) alignment
Range on Protein: 3-239
Range on HMM: 40-275/278.0
ARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKT
|..|.||.|||| .|..||||||.|. ..||.||||||||.. ||. ... |||.|||||  .| |||||||.....|||||.|||||..||..|||...
allpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggs

ETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAK
.|||..||||   | ..|| .||. ... . . ||.|...|.. ||| |||   . .| | ..||  .. . |||.|||||||||||..|... .|||..
ltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqle

KSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
| ..||. . .  ||. ||..||| .|| |.. |.||
keggvdleeavkelreqRpgavqtpsqyrflyealle

DSPc_SM00195 3-241 7.9e-85 279.7 In-house 21-262 (263) alignment
Range on Protein: 3-241
Range on HMM: 21-262/263.0
ARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK-
|.|..||.|||| ||. |||.|| |.. ...|.||||||..| |.   ....|| |||||  .| |||||||.... |||||. .| ||.||..|||.. 
aekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees

--TETYGGVTVTLHQSEIFA-DYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAML
  .||.| ..|.| . |.   ....||. |.| ... .| |.|.... |||.|||. .. ||.. |.|.  . .  ||..|||||||||||....|| .|
ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiil

EQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
.. ..  .||| . . .||| ||.||||.|||.||. |.||..
skleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 3-241 7.9e-85 279.7 In-house 21-262 (263) alignment
Range on Protein: 3-241
Range on HMM: 21-262/263.0
ARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK-
|.|..||.|||| ||. |||.|| |.. ...|.||||||..| |.   ....|| |||||  .| |||||||.... |||||. .| ||.||..|||.. 
aekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees

--TETYGGVTVTLHQSEIFA-DYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAML
  .||.| ..|.| . |.   ....||. |.| ... .| |.|.... |||.|||. .. ||.. |.|.  . .  ||..|||||||||||....|| .|
ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiil

EQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
.. ..  .||| . . .||| ||.||||.|||.||. |.||..
skleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Ptp69D_pd Subfamily Ptp69D 3-260 2.2e-83 274.9 In-house 43-305 (307) alignment
Range on Protein: 3-260
Range on HMM: 43-305/307.0
ARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-DK
. |  |. |||| .|.|.|. ||.|...||.|||||||||||.||. . ..|||.|.|.    . ||||..||... ||||.|| |  . ||.|||| ..
sekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykek.kkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpied

TETYGGVTVTLHQSEIFADYEIRTFILSKAKRSG-----SRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDA
.  || . |.| ..|   || ||.. .|| | ..     || | |.|.| |.|  ||. |...| . ..|| |.  . .|..|||||||||.| .. .| 
evqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvalds

MLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKL
.|.| |.  .||| .    ||..|. .||  |||.|.. |.|.  . |.|... .....|...|
llqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl

0040439 (Phosphotyrosine protein) phosphatases II 3-241 5.9e-83 273.5 In-house 6-246 (249) alignment
Range on Protein: 3-241
Range on HMM: 6-246/249.0
ARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-DK
|..|.||.|||| .|..||||||.|. ..| ..|||||||.|.||. ..| ||| ||||| ..| ||||.||.....|||||.|||||. ||..||| ..
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplgg

TETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVGRTGAYIVIDAMLE
. .||..|||| . |...|| .||. |.. . . ||.|.....| ||| |||..   .|.| ..||  . .  . |||.|||||||||||..|... |||
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmle

QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
| .| ..||. ...  ||. ||..||. ||| |.. |.|| |
qlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

0042113 (Phosphotyrosine protein) phosphatases II 3-240 3.9e-81 267.3 In-house 4-242 (245) alignment
Range on Protein: 3-240
Range on HMM: 4-242/245.0
ARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP-DK
|..|.||.|||| .|..|||.||.|  ..||.||||||||...||. ||. |||.|||||  .| ||||.||.....|||||...|||. ||..||| . 
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

TETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP-RDAGPVIVHCSAGVGRTGAYIVIDAMLEQ
. |||..||||   |...|| .||. ... . . ||.|...|.. ||| ||| .   .| | . ||      . |||.|||||||||||..|... ||||
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
..| ..|.. . .  ||. ||..||| .|| |.. |.|| 
lekelgvsleeavkelrsqRpgavqtpsqyrflyeallel

subfamily_PTPN6_pd Subfamily PTPN6 3-239 8.6e-80 263.0 In-house 49-295 (306) alignment
Range on Protein: 3-239
Range on HMM: 49-295/306.0
ARKPANKNKNRYANIVAYDHSRVVLErVNGDEDSDYINASFIH-GYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
..|| ||.|||| ||. .||.||.|.  ..  .||||||..|.    |. .|.||.|| |.   . ||||||..||. |||.|. || || || .||||.
gakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPde

T--ETYGGVTVTLHQSEIFADYEIRTFILSK-AKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRA----LNPRDAGPVIVHCSAGVGRTGAYIVI
.  |.|| ..||  ...  |||..|.. .||  | . .| |.|.||..|||.|||.   |||.| ..|..    |. ..|||..||||||.||||..|||
eekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfivi

DAMLEQAKKS---RTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
|..|.. .|.     .||..    .|. |  .|||..|| |.. |. .
Dillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 3-292 1.1e-79 262.9 In-house 38-326 (515) alignment
Range on Protein: 3-292
Range on HMM: 38-326/515.0
ARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD--
|..  | .|||| ||. || .|| || .| . .|||.|||.|...|   ...||||||.. . . |||.|...|   |.|.|.| |  | || |||||  
aqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdn.dkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp

-KTETYGGVTVTLHQSEIFADYEIRTFILSKAKRsgSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLE
 ..  .| . | |   |  ..  .|.. . | .   || | ||||| |||||||. ....| . ..|.| . . . |.|.|||||||||| .| || .. 
gdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvva

QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLASVNRKFQMTGYALEFQRLNSVTSrEIPAEEK
.||..|.||. |..  .|..||..|||.|||.||. |||| |   || |    . . .| | |       .  . ||| |.|..  . || . 
hakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlkslcp.dppasqt

0037934 (Phosphotyrosine protein) phosphatases II 3-239 5.6e-77 253.8 In-house 5-240 (243) alignment
Range on Protein: 3-239
Range on HMM: 5-240/243.0
ARKPANKNKNRYANIVAYDHSRVVLervngdEDSDYINASFIHGYDgtpRsFIASQGPLPPAFEG----FWRMVWEQNSQSIVMLTNLVELGKTKCHKYW
|..|.|..|||| .|..||||||.|      |.||||||..| ...   | .||.|||||  .|     ||||.||.....|||||.|||||. ||..||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvtp...r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PDKTeTYGGVTVTLHQSEIFADYEIRTFILSKAK-RSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAL--------NPRDAGPVIVHCSAGVGRTG
|... |||..|||| ..| ..|| .||. |.  .    .|.|...|.. ||| |||.  . .|.| ..||.         .  . |||.|||||||||||
pgev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

AYIVIDAMLEQAkksrTVDIRNYLIALRKDRPH-MVQTKEQYSFIHSAVLE
..|... ||..     .||. ...  ||. ||. .||| .|| |.. |.||
tliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 3-253 4.6e-75 247.5 In-house 46-296 (297) alignment
Range on Protein: 3-253
Range on HMM: 46-296/297.0
ARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGtprSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKtKCHKYWPDKT
|.|  | .|.||.||. || ||| |. || | ||||.||||..|.      .|..| | . . . ||.||.... . ||||... |  | || .||.||.
aekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg

-ETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQ--YATAVLAFRRKVRALNPRDAG-PVIVHCSAGVGRTGAYIVIDAML
  |.| |.|.|.  .    .  |.. ..| |    |.|.|..|. |||| |..   |...| .   ||      |  |..|||.||||||| .. || ..
vttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvv

EQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENY
 .||.  .||| ...  ||..||..|||||||.|.. |||||| . .|.||.. .
aeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyf

subfamily_PTPN13_pd Subfamily PTPN13 3-242 4.2e-68 224.6 In-house 32-270 (273) alignment
Range on Protein: 3-242
Range on HMM: 32-270/273.0
ARKPANKNKNRYANIVAYDHSRVVLERVNGdedsdYINASFIHGYDGTP-RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
..| .||.|||| |.. ||..|| |.   |     |||||.|.   |    ..||.||||| . . ||.|||||... |.|.|. .| || |||.|||..
gkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPes

TE----TYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPrDAGPVIVHCSAGVGRTGAYIVIDAM
..     .. ..|.| . .   .. .|.. ... . . || | ...|. ||| |||. |. .| | ..|| |.  ||||..||||||.||.|..|.||..
knkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvv

LEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALT
|.  .. . .|... .  ||. |  .||||.|| |.. |.||.|.
lglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

0049772 (Phosphotyrosine protein) phosphatases II 3-243 3.8e-42 140.5 In-house 41-282 (314) alignment
Range on Protein: 3-243
Range on HMM: 41-282/314.0
ARKPANKNKNRYANIVAYDhSRVVLERVNGDeDSDYINASFIHGYdgtpRSFIASQGPLPPAFEGF----------WRMV--WEQNSQSIVM--------
|....|..|||| .|. .| .||.| ..... .|||||||...|.    ..|||.||||.  .. |          ||||  ...|.  |||        
adlflnrdknryldilpad.nrvilpglpvs.gsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------LTNLVELGKTKCHKYWPDKTetyggvtvtlhqseifadyE-------IrtfilskakrsgSRMVRQFHFTVWPDKGVPqYATAVLAF
             |..| ..|   . .....                     |                    .|.. ... . .|| ..|     ...|
elsrLdaAlgKtpllildgngneptaadlellk...................eelydpelf............erlgikylripvpDgsap.lledfdef

RRKVRALnpRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKksrtVDIRNYLIALRKDRP-----HMVQTKEQYSFIHSAVLEALTC
 . ....  .. |||.|||.||.|||| ..|.. .. . .    |...  |  .|. ||     ..... ||| ||. |.||.|  
lefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylkf

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 3-165 3.1e-33 109.9 In-house 28-192 (297) alignment
Range on Protein: 3-165
Range on HMM: 28-192/297.0
ARKPANKNKNRYANIVAYDHSRVVLERVNgdEDSDYINASFIHGY-DGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK
|....   |||| .|.|.| .|| | ||    ..||||| ..    . ..  .| .||||  . . ||..|.||. . |||...| | |. ||  |||. 
akrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

TE--TYGGVTVTLHQSEIFADYEIR-TFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRK
 .     |  |  . |.   ...      |    || ||.||   |  |||.|||     .  |. .
vqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaq

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 3-48 4.6e-14 46.6 In-house 42-87 (440) alignment
Range on Protein: 3-48
Range on HMM: 42-87/440.0
ARKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYD
|  | || |||| ||.|||||||.|| |.|  ||||||||.| | .
aslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 3-151 2.2e-11 37.8 In-house 91-234 (244) alignment
Range on Protein: 3-151
Range on HMM: 91-234/244.0
ARKPANKNKNRYANIVAYDHSRVVLERvnGDEDSDYINASFIhGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVElgktkCHKYWPDKT
| .| |  ||| .  . .| .|| | .  |     ||||||. |  |    .| .| ||  .   ||.|. |.  . .|.|  . |       .||||  
afnpnnswknregaglpfdfnrvplsk..gsmgntyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....edeywpdse

--ETYG-GVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKG
  | |   .|||| . . | .     . .        . .  |  . ||  |
plewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdg

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 4-279 3.1e-109 359.9 In-house 42-318 (318) alignment
Range on Protein: 4-279
Range on HMM: 42-318/318.0
RKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK-T
 .|.||.|||||||.||||.|| |. ..|.|.||||||..| ||    ...||.|.||| ..| ||||||||||. |||||...| ||.|.|.|||.| .
lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgs

ETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALN-PRDAGPVIVHCSAGVGRTGAYIVIDAMLEQA
..|| ..|.|...  ..|| .|.| ... . . ||.|||.|.| |||.|||. .. .|.. |.|.. . . .|||..||||||||||| .|..|..||..
rsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdilleri

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLASVNRKFQMTGYALEFQRL
|.  .||. ..   ||. |. ||||..|| ||. ..||||..|.||..... .. ...|  .. .  .|   .|||||
kaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpesgttemdaefqrl

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 4-261 3.5e-89 294.0 In-house 42-303 (305) alignment
Range on Protein: 4-261
Range on HMM: 42-303/305.0
RKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTE
.| |||.|||...|. .|..|. |   . ..||||||||...||..   ..|..||||.   . |||...|   ..|||||.||| || ||..|||... 
kkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrk.kkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpeskt

T---YGGVTVTLHQSEIFADYEIRTFILSK-AKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAG-PVIVHCSAGVGRTGAYIVIDAML
    .| ..|.|.... ..|| .| . .|.  . . || | |...| |||.||||.||..| . ..|.    .| | |..|||||||||||..|..| .|
ekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdial

EQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLA
|..||  .||. ..| .||. |. ||||..|| |.| |. | .|||.|.|  .|.. ...|| 
erlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnklk

0045098 (Phosphotyrosine protein) phosphatases II 4-244 4.3e-79 261.1 In-house 29-275 (278) alignment
Range on Protein: 4-244
Range on HMM: 29-275/278.0
RKPANKNKNRYANIVAYDHSRVVlervngdedsDYINASFIHGYdgtPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKT-
 .. |..|||| .|..||||||.          ||||||.|.||   |. ||| |||||  .. ||||.||.....|||||.|||||. ||..|||..  
lylgnldknRykdilpydhsrVk..........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggs

ETYGGVTVTLHQSEIFADYEIRTFILSKA----KRSGSRMVRQFHFTVWPDKGVPQYA--TAVLAFRRKVRALNPR-------------DAGPVIVHCSA
.|||..|||| . |.. || .||...       .   || |...|.. ||| ||| .   . .| . . .|. . .             . |||.|||||
ltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GVGRTGAYIVIDAMLEQAkkSRTVDIRNYLIALRKDRPH-MVQTKEQYSFIHSAVLEALTCG
||||||...... |||.    ..||. ...  ||. ||. .||..||| |.. ..|| | .|
GvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg

subfamily_CG7180_pd Subfamily CG7180 4-245 1.2e-65 216.1 In-house 38-294 (296) alignment
Range on Protein: 4-245
Range on HMM: 38-294/296.0
RKPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKtKCHKYWPDK-T
 .  |..|||. ..| ||. |||||...|.|.||||||... ..   .. .|  ..|   . . |||.|........|.||.  .  | ....||| |  
lrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnksk

ETYGGVTVTLHQSEIFADYEIRTFILSKA----------KRSGSRMVRQFHFTVWPD-KGVPQYATAVLAFRRKVRALNPRD-----AGPVIVHCSAGVG
| || . | . ... .|. .|||| | |                |.|..|..|.|.  . ||  ..|.. .||.|| .  .       |||.|..| |..
eqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGas

RTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
|.|.|. ||| ||...|   ||. ...  ||..||..|...|.| .|   .|||. |. 
RsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 4-239 1.6e-35 117.1 In-house 33-267 (281) alignment
Range on Protein: 4-239
Range on HMM: 33-267/281.0
RKPANKNKNRYANIVAYDHSRVVLER-VNGDEDSDYINASFIHGyDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKT
 .| |..||||.|| . | ||| |.  .   . .||| | .|.      | .| .|||   .   ||||.|..|. .|||| ...|  . || .|.| ..
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirs.pflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

ET---YGGVTVTLHQSEIfaDYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAlnpRDAgPVIVHCSAGVGRTGAYIVIDAMLE
     .  ..|.  .| .  .  . |  |  .    .|.. .. .  |||  ||. .  .|   ||.||   | . | ..||||||||.|. . ..  |.
hcclqfdklsvsyedstv..nkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira...rst.ppvihcsagvgrsgtlmaveialq

QAKKSRTV-DIRNYLIALRK-DRPHMVQTKEQYSFIHSAVLE
  .   |. ||.. .  ||   |   ||| .|| .|   .|.
sihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 5-245 2e-68 225.4 In-house 43-287 (290) alignment
Range on Protein: 5-245
Range on HMM: 43-287/290.0
KPANKNKNRYANIVAYDHSRVVLERVNGDED--SDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK-
 . ||..||.|||| ||  |..| ...|..|   .||||..|.||    ...|| |||..     ||...|....  |||||| .| ||.||..||||. 
tssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsd

TETYGGVTVTLHQSEIFADYEIRTFILSKAKR-SGSRMVRQFHFTVWPDKG-VPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLE
|..|| ....|.. |.. .| .|.. . . .    ...| |...| |...| |....| .|.... ..    |  ....||||..|||.. .....  ..
tkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattin

QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGN
..|.   .|. . |  .|  .| .|||..|| .|.. ||..|.. .
kcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 5-240 3.3e-38 126.2 In-house 45-286 (305) alignment
Range on Protein: 5-240
Range on HMM: 45-286/305.0
KPANKNKNRYANIVAYDHSRVVLervNGDEDSDYINASFIHGyDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTE-
.  ...|||| ..   |. || |   .|    .|| | ..      |. || .| ||  .   || | .... ..| || ||.| |  ||..|.. | . 
eaqeagknrykdvgcldnnrvkl...egpwpheyihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkd

------TYGGVTVTLHQSEIF-----ADYEI-RTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNprdaGPVIVHCSAGVGRTGAY
          ..| .  |. .     |. .. .| .. .   . .| | ..|.  |||.|||   .|.| .  | |..     ||..||||||.||||. 
vlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk....gpivvhcsagigrtgsv

IVIDAMLEQAKKSRTVDIRN-YLIALRKDRPHMVQTKEQYSFIHSAVLEA
.... .|.|    . ..  .  |  .|..|   .|| .|| |.|  .|. 
vmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilny

subfamily_ptpA1_pd Subfamily ptpA1 5-199 7.5e-36 118.7 In-house 44-254 (418) alignment
Range on Protein: 5-199
Range on HMM: 44-254/418.0
KPANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGydGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKT--
|  | .||||.||.  .|.|| |....  | |||||| .| |    |. ||..||||| .   |||||||.  . ||||.   |  . || .|||..   
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigg

----------ETYGGVTVTLhqSEIFAD--YEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAF-----RRKVRALNPRD-AGPVIVHCSAG
          | .|  .| |   |.  |   || |  .  .    .| . |...  |||. .|...  .  .      |. . .   |   |.|||||||
eqfsiygngnevfgtysvel..veviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsag

VGRTGAYIVIDAMLE
|||||..     |..
vgrtgtfctavimmk

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 6-261 1.6e-82 272.3 In-house 59-311 (319) alignment
Range on Protein: 6-261
Range on HMM: 59-311/319.0
PANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTnlvelgKTKCHKYWPDKT-ET
. ||.|||. ||.|.|...| |||..| | ||||||||. ||   .  .||.||||. . . ||||.||.|. .||.||      | || .||| |. ..
dqnkdknriinilafdknvvklerliGeefsdyinasfvtGyq.rkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

YGGVTVTLHQSEIFADYEIRTFILSK-AKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAG--PVIVHCSAGVGRTGAYIVIDAMLEQA
..   | ..  |  |.| .| . ||. .|  . | ..||||  |||.|||.|.. .. . .||| |. .  .  ...|||||||||||.|||.|..|.. 
eerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrm

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLA
|. . ||. |..  ||..|...||   || ||.||.||    |....   ..   ...|.
keekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleels

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 6-261 1.6e-81 268.9 In-house 23-275 (284) alignment
Range on Protein: 6-261
Range on HMM: 23-275/284.0
PANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTnlvelgKTKCHKYWPDKT-ET
. ||.|||. .|.|.|...| |||. | | ||||||||| ||   .  .||.||||. . . ||||.||.|. .||.||      | || .||| |. ..
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

YGGVTVTLHQSEIFADYEIRTFILSK-AKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAG--PVIVHCSAGVGRTGAYIVIDAMLEQA
..   | ..  |  ..| .| . ||. .|  . | .|||||  |||.|||.|.. .... .||| |. .  .  ...|||||||||||.|||.|..|.. 
eerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrm

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQAMQKLA
|. . ||. |..  ||..|...||   || ||.||.||    |....   ..   ...|.
keekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleels

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 6-239 4.9e-73 240.6 In-house 26-266 (274) alignment
Range on Protein: 6-239
Range on HMM: 26-266/274.0
PANKNKNRYANIVAYDHSRVVLERVNGDE-DSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTET
. ...|||| .|.  ..|||.||. .... ||.|||| .|.|||.. . ..| ||||| . . ||||......| |||||.| |  ..||..|.||....
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

-----YGGVTVTLHQSEIFADYEIRTFILSKAKRsgSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR---DAGPVIVHCSAGVGRTGAYIVIDA
     ||.| .. ..     ||..|...|....|  .| |  . .| |||. .|. |...| . ..|.  . .    ..||.||||||.||||..| |. 
eiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

MLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
 . | ... .||. .    || ||  ||||.||| .|| |. .
avrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 6-248 2.1e-69 228.7 In-house 45-285 (287) alignment
Range on Protein: 6-248
Range on HMM: 45-285/287.0
PANKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKT-ET
. ||.|||...|. .|  ||.|.    .|. |||||.|| ||    . ||....|.  .   ||......| . ||||... |  . .|..|||...  .
sqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykek.kafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvv

YGGVTVTLHQSEIFADYEIRTFILSKAK-RSGSRMVRQFHFTVWPDKG-VPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAK
.|  ...| . |. |.| .|.. . . .  .  ..|.|...| |...| |....| .| . .....   |  ....||||..|||.. .. ..  ....|
lGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkck

KSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEI
.  ..|. . |   |  .|..||| ||| ||  .||| |....|  
teGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys

subfamily_CG42327_pd Subfamily CG42327 6-167 1.8e-37 123.7 In-house 26-191 (319) alignment
Range on Protein: 6-167
Range on HMM: 26-191/319.0
PANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD-----
.. |.|.|..|.|   ..||||.|.  |. . |..||.. ||| .| |.||.| .|  .   |||.||||.|. || ||.| |||  .| .|.|      
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

KTETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFtVWPDKGVPQYATAVLAFRRKVR
 |..|| . ||| . |.   | | |..| . ... || .  . .  |.. .||   .|..|   .||
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 6-59 4e-10 33.7 In-house 46-95 (95) alignment
Range on Protein: 6-59
Range on HMM: 46-95/95.0
PANKNKNRYANIVAYDHSRVVLErvnGDEDSDYINASFIHGYDGTpRSFIASQG
 ||  |||. ||. || .||||       ||||||| |. ||      .||.||
eanipknrflnifpydatrvvlt...tkrdsdyinacfvdgyark.ncyiaaqg

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 7-239 3.5e-91 299.7 In-house 2-237 (237) alignment
Range on Protein: 7-239
Range on HMM: 2-237/237.0
ANKNKNRYANIVAYDHSRVVLERVNGDedSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD--KTET
 || ||||.||||||||||||.   ..  ||||||....|.||||...||.|||| .. . ||.|||...   ||||| |.|  . |||||||.  . ..
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGGVTVTLHQSEIFADYEIRTFILSKA-KRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPR--DAGPVIVHCSAGVGRTGAYIVIDAMLEQA
|| .||.|.. | |.|| .|...|||  .  . |.. |..||.|||.||||...|.| ||...   .|   ..|| |.|||||||||| ..|||||| ||
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
|. . ||| ||. .. .|||...|||.|| ||| ..||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 7-239 8.1e-65 213.5 In-house 19-262 (270) alignment
Range on Protein: 7-239
Range on HMM: 19-262/270.0
ANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTET--
 .|. ||||.|.   ..||.||... |. . |||| ...|.|| ....||..|||| . . ||||.||.....|||.|.|.| |..|| .||| ....  
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

---YGGVTVTlHQSEIFADYEIRTFILSKAKRSGSRMVrQFHFTVWPDKGVPQYAT------AVLAFRRKVRALNPRD--AGPVIVHCSAGVGRTGAYIV
   .| ..|.  .||  ..  |.| .  . | .  |.|  |... |||.|||. .        .|.  |.||. . .   |.|..|||||||||||  |.
kledgkikvl.alseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
.| ...  .... ||. . . .|||||. .||. ||| |.. ||.|
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 7-247 5.2e-57 187.8 In-house 39-299 (301) alignment
Range on Protein: 7-247
Range on HMM: 39-299/301.0
ANKNKNRYANIVAYDHSRVVLERVNG--DEDSDYINASFIHGYDGTpRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD---K
.||. ||. ||. ||. |..|.  .       .|||||.|.||  . . |||.|||.      |||..|..  .||||.||| |  |.||..|||.   .
enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysek.kkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseae

TETYGGVTVTLHQSEIFADYEIRTFILSKA---------------KRSGSRMVRQFHFTVWPDKGV-PQYATAVLAFRRKVRALNPRDAGPVIVHCSAGV
.|..| .||||... .. |. || . .                  ..  |. | |.. | ||. || ....| . .    . . .  . |||.||||..|
seefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtV

GRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTE
.|.| |. ..  |||.|    ||. .   |.|. .| .|.| |||..|. .. . |.. .|.
srsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 7-251 2.8e-55 182.2 In-house 32-276 (283) alignment
Range on Protein: 7-251
Range on HMM: 32-276/283.0
ANKNKNRYANIVAYDHSRVVLERVNGdedsDYINASFIH--GYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDK-TE
 ||.|||. .||..|  || |.  .     |||||.||     .   . .|..|.||  .   ||.||....  .|||||.| |  . || .||| . .|
enkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGse

TYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRM-VRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAK
 ||  ||||..      . |. ..| .   . | . .  . .  | . |      ... | . .   .    ||..||||.|.|||...| . | ...|.
dyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdal

KSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSE
 .  ||. . .  .|..|. .|||..|| ..| .|||   ||.|.|   
tesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaav

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 7-241 2.5e-43 143.2 In-house 40-277 (307) alignment
Range on Protein: 7-241
Range on HMM: 40-277/307.0
ANKNKNRYANIVAYDHSRVVLErVNGdEDSDYINASFIhGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD---KTE
|| .|||| .. . |..|.|.. ..|   |||| | .. |    |. ||..||||  .   || |. ... .|..|| ...||.| ||..|||    .. 
antdknryqdvkcqdkgrivvk.fdg.lasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqkl

TYGGVTVTLHQ-----SEIFADYE-IRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFrrkVRALNpRDAGPVIVHCSAGVGRTGAYIVIDAM
..|  . |.        ..  | . |    |     ..|| .... .. |||.||||   . . .   . | .  |  ||.|||||||||.|. . |  .
vfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainl...leavr.ydtnpvvvhcsaGvGrsGtivaislv

LEQAKKS-RTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
 ..  .     |... .  ||..|.. .||. || ..|  .|| .
qdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 7-241 1.1e-31 104.9 In-house 34-270 (285) alignment
Range on Protein: 7-241
Range on HMM: 34-270/285.0
ANKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTE---
|| . ||||.. . . .||||.    . | ||| ||...       ..|..||||| ..  ||.|.....   ..||  |.| |  ||  |.|.|     
anpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

TYGGVTVTL--HQSEIFADYEIRTFILSKAKRSGSRMVRQFH--FTVWPDKGVPQYATAVLAFRRKVRALNPRDAgPVIVHCSAGVGRTGAYIVIDAMLE
 .|   .||   . |  |   . .. . ... . |  .   |     |||.  |. |  .. . . |. .||..  |. |||||||||| ... ||    
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek.picvhcsagvgrtatfvgidyati

QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
.  .   ... . .  .|  | . ||.. |. |..  ..| .
rimenpniemldivremramrfqavqshmqflflyvvlmeyf

subfamily_egg_pd Subfamily egg 7-238 1e-23 78.5 In-house 39-267 (307) alignment
Range on Protein: 7-238
Range on HMM: 39-267/307.0
ANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELgkTKCHKYWPDKT-ETY
 |..| |   .   | ||| ||  .|    |.| |  ..|       || .| ||  . . |||||.... | |||||  .|    .|. |||    .. 
nnlekarskrvhckdssrvklelrrGqylddfihanrvkGkp.llnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdsl

GGVTVTLHQSEIFADYEI-RTFILSKAKRSGSRmVRQFHFTVWpdKGVPQYATAVLAFRRKVRALNpRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKS
  |  .|.   .  | .    | ..| |  |.    . .   |  .|  .... |    | .| |  . . ||.|..  || .... . |.  | .  . 
vtvpGslrienlkvdskadplfrvtklklvGgd.deerflehw..qgdvnnssdvysplrvlrklr.nlskpvvvqdilGvskaatlvaieiallsllrG

RT--VDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
 .    ...    ||. |.  |..  .| |..  ||
pitkslvlravvflrlrrrlsvesvllylfvyrlvl

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 7-238 2.3e-22 73.8 In-house 50-282 (302) alignment
Range on Protein: 7-238
Range on HMM: 50-282/302.0
ANKNKNRYANIVAYDHSRVVLERvngdEDSDYINASFIHGYDGTpRSFIASQGPLPP---AFEGFWRMVWEQNSQSIVMLTNLVELGKtKCHKYWPDKTE
.| .||.  .. ..|. .| ||     |  .|.||| ..  . | || | .| |      . | |||||.... .|.|.|    || |   ....| |..
knlkknqsedvpildsnlvklea....epdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

T---YGGVTVTLHQSEIFADYEiRTFIL--SKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAML
.   || . |   . |   . .   ...       | | ..   ..| |..| ||.  ... .   || |..     ....    |.|| || ..  . .
dykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavav

EQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
|. .|.  . | . ....|..||..|.. .|| ... |.|
eklqkgkepnikeivksiRsqRpravdslkQyvslyiall

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 7-103 5.1e-11 35.8 In-house 26-89 (169) alignment
Range on Protein: 7-103
Range on HMM: 26-89/169.0
ANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINAsfihgydgtprsfiasqgplppafegfwRMVWEQNSQSIVMLTNLVElgktkCHKYWPDKTE
.|. ||| |  .|  | || |.||  |  ||||||                            ||.|| |.  ||.| .  .        .||.| .
cnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlgdtdd.....knnfwpeked

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 7-103 6e-11 35.4 In-house 25-88 (169) alignment
Range on Protein: 7-103
Range on HMM: 25-88/169.0
ANKNKNRYANIVAYDHSRVVLERVNGDEDSDYINAsfihgydgtprsfiasqgplppafegfwRMVWEQNSQSIVMLTNLVElgktkCHKYWPDKTE
.|. ||| |  .|  | || |.||  |  ||||||                            ||.|| |.  ||.| .  .        .||.| .
cnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlGdtdd.....knnfwpeked

Y_phosphatase Protein-tyrosine phosphatase 8-239 3.4e-82 270.8 Pfam-A 1-235 (235) alignment
Range on Protein: 8-239
Range on HMM: 1-235/235.0
NKNKNRYANIVAYDHSRVVLervNGDED-SDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKTE
||.|||| .|..||..|| |   .|.|. ||||||....||. ....|||.||||.  .| ||||||......|||||.|.| |..||..|||   ....
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

TYGGVTVTLH-QSE-IFADYEIRTFILSKAKRS-GSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQ
||| ..|.|  ... . ..| .|.. |.| |..  .|.|.|.|.| |||.|||. ....| . |||.  .  . |||.||||||||||| ....|..|||
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
... ..||. ...  ||| ||.|||. ||| |.. |.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 8-239 3.4e-82 270.8 In-house 1-235 (235) alignment
Range on Protein: 8-239
Range on HMM: 1-235/235.0
NKNKNRYANIVAYDHSRVVLervNGDED-SDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKTE
||.|||| .|..||..|| |   .|.|. ||||||....||. ....|||.||||.  .| ||||||......|||||.|.| |..||..|||   ....
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

TYGGVTVTLH-QSE-IFADYEIRTFILSKAKRS-GSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQ
||| ..|.|  ... . ..| .|.. |.| |..  .|.|.|.|.| |||.|||. ....| . |||.  .  . |||.||||||||||| ....|..|||
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

AKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
... ..||. ...  ||| ||.|||. ||| |.. |.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 8-255 6.4e-66 217.6 In-house 48-293 (439) alignment
Range on Protein: 8-255
Range on HMM: 48-293/439.0
NKNKNRYANIVAYDHSRVVLERVNGDEDSDYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKtkchkYWPDKTETY-G
.. |||| ...|.||.||.|. . |   | |||| .|.||  ... .||.|||   . . |||.|.|...  |||||||||  |     ||| ..|.. |
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcyg

GVTVTLHQSEIFADYEIRTFILSKAKR--SGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNP-RDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKK
 ..|   .   . .| || | . . .      | | |||.. |||| ||  |. || | | . . |  .. |||.|||||||||||. | .|  ||| | 
diavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlkl

SRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSENYNQ
   |||.  .  |||.| .|||.  || ||. |||| .  |.. .. .....
enkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkk

subfamily_PTPN23_pd Subfamily PTPN23 8-240 2.1e-59 195.7 In-house 43-279 (288) alignment
Range on Protein: 8-240
Range on HMM: 43-279/288.0
NKNKNRYANIVAYDHSRVVLErvngDEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKTET
. .|||. .|. |||.||.|.    ..  |||||||...   .  .|||.|.||...   ||.||.|| |. ||||..  ||||.|...|||   ..|..
yseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvk

YGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRA----LNPRDAGPVIVHCSAGVGRTGAYIVID-AMLE
.| ..|||.. .    .  |...|.  . .  ..|.  ..| ||. |||.    .|.|  .|..     . .   |..|||||||||||.. ..  |. |
fgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavre

QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
  |.   .|| . .  ||..| .|||.|||. |  .|||||
lekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

0041856 (Phosphotyrosine protein) phosphatases II 8-247 8.7e-51 167.4 In-house 1-177 (182) alignment
Range on Protein: 8-247
Range on HMM: 1-177/182.0
NKNKNRYANIVAYDHSRvvlervngdeDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTnlvelgktkCHKYWPDKTetygg
|..|||| .|. |||||          |.|||||... |.  . | ||| ||||.  .. |.||..|.. ..||.||         .. |||..      
nldknrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywpell.....

vtvtlhqseifadyeirtfilskakrsgSRMVRQFHFTVWPDKGVPQyATAVLAFRRKVRAlnprDAGPVIVHCSAGVGRTGAYIVIDAMLEQakksrTV
                             |.. |.... ||| |||     .|.| ..|..    . |||.|||||||||||...... |...      |
............................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTE
.... .  .|. ||.||.| .|| |.. |.|| | ...|.
sleeavklvrsrRpgmvitpnqyfflqlallellllkktr

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 8-239 1.9e-44 146.5 In-house 56-281 (290) alignment
Range on Protein: 8-239
Range on HMM: 56-281/290.0
NKNKNRYANIVAYDHSRVVLErvNGdEDSDYINASFIHGydgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKT---ET
. .|||| ..|  | .||.|.  .|  | ||. | ...|   .   || .||.|  .   .|||| ...   |||| .|.| ||.||..|.|.|     |
efkknrykdvvcndktrvilk..dG.ydGdyvhanyvkG...lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

YGGVTVTLHQSEIFADY-EIRTFILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALnprdAGPVIVHCSAGVGRTGAYIVIDAMLEQAKK
.| .||.  ...   .    .|. . . .   . ... ..   |||| |.. . |.|   | .| .    .|||.||||||.||||... |.. |.   .
fGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievglqilld

SRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
 . .|. .   |||. |   ||   ||  .  ..|.
Gkeldlldlvralrnsrlnsvqvdiqylalveilld

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 8-239 6.4e-40 131.8 In-house 33-257 (267) alignment
Range on Protein: 8-239
Range on HMM: 33-257/267.0
NKNKNRYANIVAYDHSRVVLERVNGDedsdYINASFIHGYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNlveLGKTKCHKYWPDK---TET
|...||. . . ||..||.|   . .    |||||...||  | . ||. |.||  .   |. .. .|.   ||.||.    .. . ...|| |   .. 
nqernrlddnlpyddtrvilrtkeee....yinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltk...vftdnirlfwPPkmgqakk

YGGVTVTLHQSEIFADYEIRTFILsKAKRSGSRMVRQFHFTVWPDKG-VPQYATAVLAFRRKVRALNprDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKK
|  .||     .   ||.| |. | | |   .. |  ...  |  .     |   ...   | .  |     |..|.||.||||.|...|||..||.||.
yqdltvehslekeendyqiitlel.kfknesahnvtlyyykkwnintnnkpylkplfgilaknqlen..gnrPlvvacsdGvGrsGtflvidsqlerakt

SRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
  ..|| ..|  .|. |. .|.|||.| .||  . |
egvsdifdflrkirsqriglvdtkeryiyihellae

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 8-239 2.5e-39 129.7 In-house 55-287 (305) alignment
Range on Protein: 8-239
Range on HMM: 55-287/305.0
NKNKNRYANIVAYDHSRVVLERVNgdeDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP----DKTE
.. ||||... . |.| | |.. .    |||| | ..       . ||..||||  . . || || ... . |||| . ||||| || .|||    .| |
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

TYGGVTVTLH--QSEIFADYEIRTFILSKAKRSGSRM-VRQFHFTVWPDKGVPQYATAVLAFRRKVRAlnprDAGPVIVHCSAGVGRTGAYIVIDAMLEQ
  .|. |        .  | ||.  .|  .   . .| ||....| |||.|||    . | .   .|        |..||||||.||||. . |. .||.
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtivaieyilek

AKKSR-TVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLE
  . .    . . . ||| .| . .|.  || |||  .|.
iaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 8-251 1.2e-35 118.0 In-house 43-281 (288) alignment
Range on Protein: 8-251
Range on HMM: 43-281/288.0
NKNKNRYANIVAYDHSRVVLErvngdEDSDYINASFIHGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTE---T
|  ..|| |.   | .|| |.     .|.|.  |. .      .| .| .| ||  . | .|.|. |.. . ||||..|.|.|| |  .|.| |      
nptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

YGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRM-VRQFHFTVWPDKGVPQYATAVLAFRRKVRALNprdaGPVIVHCSAGVGRTGAYIVIDAMLEQAKK
.| .     ..    |  ..  .|   |    .. |.. |.  |.|.|||.   . | .   ...|.     |..||.||||||||. |.|  .||... 
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhssaGvGrtgtlililialeslrl

SRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSE
.  . ||. |  ||..| . .||. || ..|  ||| |     . . |
ddflgirsllaklreerfkaiqtemqylyvhrcvleelllkkykvlre

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 8-249 1e-34 114.5 In-house 52-297 (310) alignment
Range on Protein: 8-249
Range on HMM: 52-297/310.0
NKNKNRYANIVAYDHSRVVLErVNGDEDSDYINASFIHGyDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD--KTETY
.  ||||...|  | ||| |. ..     ||| | ...  .    .|| |||||  .   ||||.... ..||..| . .| |. ||  |||    ||||
ymhknrysdvvcldtsrvklk.idksryedyihanyvkt.nylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

GGVTVTlHQSEIFADYEIR----TFILSKAK------RSGSRMVRQFHFTVWPDKGVPQYATAVLAFrrkvRALNPRDAGPVIVHCSAGVGRTGAYIVID
| . ||   ||   ..||     ||.  .              |   ..  |||.|||.     .      | |     ||..||||||..|... . ..
gcirvt.nlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq....rllaqvrhgpcvvhcsagkdrlyvvvalk

AMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLeALTCGNTEIQ
  ......   ||. .    |.|.|   .||. || .|.   . ... |.||. 
lkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargeteva

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 8-259 6e-30 99.0 In-house 50-298 (301) alignment
Range on Protein: 8-259
Range on HMM: 50-298/301.0
NKNKNRYANIvAYDHSRVVLERVNGDedSDYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTET---
.|.|.|| ..   . |  |   |.|      | | .|    | |. |||.||||. . | || |.   . . ||||.. ||  ..||..| | |..    
pkdkhryptv.PckPstavevivdGk..rvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekld

YGGVTVTLHQSEIFADYEI--RTFIL-SKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRalnpRDAGPVIVHCSAGVGRTGAYIVIDAMLEQA
 |  .......|   . .|  ||. .   ...  .| |  . .. |.|.|||.  . .  .   |.    .   |..||||||.||. |.|  . .  . 
igrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvk....ksekPivvhcsaGiGrsvafigteylarev

KKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCgNTEIQSENYNQAMQK
.  .|... . |  ||..| . |||..|  ..    .  |   . ...   |.. .. 
eadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlik.eygfdmkiyeeqlam

subfamily_eak_pd Subfamily eak 8-166 3.8e-17 56.7 In-house 52-207 (332) alignment
Range on Protein: 8-166
Range on HMM: 52-207/332.0
NKNKNrYANIVAYDHSRVVLERVNGDEDsDYINASFIHgYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKT---ET
. |.|   .|| ||.  | |     ...  ||||| .  .    | .| .  .       ||.|| ||.| .||.| . |||.  |  ||.||||     
avnrn.vvkivpydrylvrltssqlnrl.Gyinaslae.fsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelk

YGGVTVTLHQSEIFADYEIRTFILSKAKRsgSRMVRQFHFTVWPDKGVPQYAtAVLAFRRKV
.| . |.  .    . .| | ..|||     .  |  ...  | .  .|.|    ||.|. .
fGildverkefvkrniletrllelskGne..thrvlhykvfGwtettlpkye.dflalrkvm

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 8-240 1.1e-16 55.3 In-house 47-278 (303) alignment
Range on Protein: 8-240
Range on HMM: 47-278/303.0
NKNKNRYANIVAYDHSRVVLervngdEDSDYINASFIHgYDgTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTETYGG
| .|||.....  |||.| |       || || ||...  | . .  | .| ||. .   ||.|. ||. . ...|    |  |   .  .| . .    
nmdknrfvdvicldhskvkl......sdssyihasyle.ld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

----VT-VTLHQSEIFADYEIRTFILSKAkrSGSRMVRQFHFTVWPDKGVPQY-----ATAVLAFRRKVRALnpRDAGPVIVHCSAGVGRTGAYIVID-A
    .    ... |.   . ..   .|.   .   ..   |.  || . .|          .   .  .|     |. | .    .|.||.|.. ... |
eersirvgefkrvelgdgwvlkvlsvsng..dyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrky..sdstptvymslsgcgragtfalfeta

MLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEA
 |   ..  ..|. . |  .|. | | ||   |.|.... . | 
hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 8-82 5.9e-09 29.9 In-house 37-115 (347) alignment
Range on Protein: 8-82
Range on HMM: 37-115/347.0
NKNKNRYANIVAYDHSRVVLER-----VNGDEDSDYINASFIHgYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVM
. .|||  .    | .||||        . |.   ||||| |. .| . . .| .| ||| .   ||.||   .   .| 
slsknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 8-91 1.4e-08 28.6 In-house 34-115 (332) alignment
Range on Protein: 8-91
Range on HMM: 34-115/332.0
NKNKNRYANIVAYDHSRVVLERVNGDedSDYINASFIHGYDGTpRSFIASQGPLPPAFEG-FWRMVWEQNSQSIVMLTNLVELGK
| . ||   . ..||||| |   .|    |. |||.. ||     ..| .| |.    |  ||||| |..   |... .. |  |
nmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskk.sayifaqapfndhteyvfwrmvserkpsmilvfgdidekqk

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 9-247 3.1e-34 113.1 In-house 44-282 (312) alignment
Range on Protein: 9-247
Range on HMM: 44-282/312.0
KNKNRYANIVAYDHSRVVLervNGDEDsDYINASFIHGYdGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTetyGGV
|. ||| ||  .|  |  |    |||.  || | |..     |  |...||||  .   ||...    | ||..|. .|| |  || ||  |     | |
kdlnrypniqcwdrgrftl...agden.fyihanfvkic.tkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdiv...gfv

TVTLHQ--SEIFADYEIR--------TF---ILSKAKRSGSRmVRQFHFTVWPDKGVPQYATAVLafrRKVRALNpRDAGPVIVHCSAGVGRTGAYIVID
 .  |.  .|  .. ||              .. ||    |. . .. .. |||.|.|.   . |   | . |.. .|  ||| ||||||||||. ..|.
dledhrvyteycteieiggkskdkithrvlkvvvkatgqesk.lnhyqwaswpdhgmpdscdtal...rllsavk.kdkkpviahcsagvgrtgtlalie

AMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTE
.|.   .. |  .... .. |||||   |..  || .   .||| | .    
smiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 10-113 1e-21 72.0 In-house 49-163 (350) alignment
Range on Protein: 10-113
Range on HMM: 49-163/350.0
NKNRYANIVAYDHSRVVLER--------VNGDEDSDYINASFIHGY----DGTPRS-FIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHK
 |||| ||. |.|||| |..            . .|||||....      .  |   .|| |.||| ... |.... . . . |..||..|||.  ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPDKteTYGGVTVTLH
||..   .| ..|| | 
YWqeg..sydditvkla

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 10-116 3.3e-13 43.7 In-house 50-169 (349) alignment
Range on Protein: 10-116
Range on HMM: 50-169/349.0
NKNRYANIVAYDHSRVVLERVN--------------GDEDSDYINASFIHGYDGTP-RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKC
 |||| .|. |.||||.|..                .    ||||| ...    .. . .|| | ||| . . |....  .. . .. |..  ||.  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HKYWPDKteTYGGVTVTLHQSE
..|| .   .| ..|| |  | 
diywqel..sysnitvklqnss

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 11-260 1e-19 65.8 In-house 22-279 (290) alignment
Range on Protein: 11-260
Range on HMM: 22-279/290.0
KNRYANIVAyDHSRVVLERVNGDEDSDYINASFIHGYDGTprSFIASQGPLPPA-------FEGFWRMVWEQNSQSIVMLTNLVELGKT----KCHKYWP
..|... ..  ..||||.       .||| |...   .|    .|..| |.           | || |. . .....||| .  |  .      | || |
dqRlevpLv.eatrvvLkgygkrfnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvp

DKTE---TYGGVTVTLHQSEIFADYEIRTFILSKAKRSgSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRalnpRDAGPVIVHCSAGVGRTGAYIVIDA
.. .   ...|.||   . |   | |.|. ..   ..     |    .  | .  |..    .|.  .||.        ||||||  |. |  |   |. 
esvgeelkfkgltvkCkskekeddvetRelvvkfddee.eftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiil

MLE-QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAV-LEALTCGNTEIQSENYNQAMQKL
     |..|  | ... | |||| | ..........|.  .. | |   ... ...|. ..|... 
gyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetekkakaee

0044763 (Phosphotyrosine protein) phosphatases II 20-238 3.6e-38 126.3 In-house 2-168 (178) alignment
Range on Protein: 20-238
Range on HMM: 2-168/178.0
YDHSRVVLERVNGDEDSDYINASFIHGYdgtprSFIASQGPlppafEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTEtyggvtvtlhqseifa
.|..||.|. . | | |||||||.| ..      ...|..|     . ......|.. ..||.||. .|||. ||..|||....                
ldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

dyeirtfilskakrsgsrmvRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQakksrTVDIRNYLIALRKD
                     |.... .|| |||.    .|.| . .... ... |||.|||||||||.|. .... |...      ... . .  .|. 
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RPhMVQTKEQYSFIHSAVL
|| .|.. .|. ...   |
Rp.ivpnpgqlrqLyefel

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 20-151 1.6e-07 25.7 In-house 5-125 (130) alignment
Range on Protein: 20-151
Range on HMM: 5-125/130.0
YDHSRVVlervngdeDSDYINASFIhGYDGTPRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVElgktkCHKYWPDKT--ETY-GGVTVTLHQSE
.. ||.         . .||||||. |  |  . .. .| ||  .   ||.|. |.    .|.|  . |       .||||    | |   ..||| . .
fevsrlq........gntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywpdsePlewyeediivtltdrd

IFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDKG
 |   .   .  ..      . .  |. . ||  |
efknikasnleiesdlneshqaltmfqisnwpsdg

0046846 (Phosphotyrosine protein) phosphatases II 30-239 8.4e-43 141.5 In-house 6-171 (176) alignment
Range on Protein: 30-239
Range on HMM: 6-171/176.0
VNGDEDSDYINASFIHGYDgtprsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTETYGgvtvtlhqseifadyeirtfils
   |.|.|||||..| |.      .|| |||||  .. |..|..|.. . .|.||..||||. ||. |||. ..                          
lgldldldyinanlilgsr.....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

kakrsgsrmvrQFHFTVWPDKGVPQYaTAVLAFRRKVRALNPRDaGPVIVHCSAGVGRTGAYIVIDAMLEqakkSRTVDIRNYLIALRKDRP-HMVQTKE
           |.... ||| |||.. ...| . . .|    .. |||.||||||.||||...... .      .. ... . |  .|. || ..||| |
...........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpe

QYSFIHSAVLE
|| |.. ..|.
Qyrflyefell

0043147 (Phosphotyrosine protein) phosphatases II 32-234 3.8e-41 136.0 In-house 1-154 (172) alignment
Range on Protein: 32-234
Range on HMM: 1-154/172.0
GDEDSDYINASFIHGYDGTPRsFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLvelgktkchkywpdktetyggvtvtlhqseifadyeirtfilSKA
|||.|||||||....|  ..| ||| ||||.  .. ||||..|.. . ||.||.|                                           . 
gdegsdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel..........................................lyd

KRSGSRMVRQFHFTVWPDKGVPqYATAVLAFRRKVRA-LNPRDAGPVIVHCSAGVGRTGAYIVIDAMLeqakksRTVDIRNYLIALRKDRPHMVQTKEQY
.   .|.. |.... ||| |||  .  .| | . ..  |. .. |||.|||||||||||. .... ||      . ... . .  .|. ||..||...||
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

SFIH
 |..
rfly

0051082 (Phosphotyrosine protein) phosphatases II 35-238 2.1e-35 116.9 In-house 2-150 (151) alignment
Range on Protein: 35-238
Range on HMM: 2-150/151.0
DSDYINASFIHGYdgtprsFIASQGPLPpafeGFWRMVWEQNSQSIVMLTNLVELGktKCHKYWPDKTetyggvtvtlhqseifadyeirtfilskakrs
 |||||.|.. |.      ...|.|||.     |.....|.. ..||.|....| |  .|..|.|.                                  
lsdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

gsRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRAlnpRDAGPVIVHCSAGVGRTGAYIVIDAMLEQakksrtVDIRNYLIALRKDRPHMVQTKEQYSFIH
  . |...... ||| |.|..  |||.| .....    . |||.||||||.||||. .... ||..      |..   |  .|. ||..||...|. |..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

SAVL
 |.|
fall

0051429 (Phosphotyrosine protein) phosphatases II 36-260 4.3e-54 179.3 In-house 4-243 (272) alignment
Range on Protein: 36-260
Range on HMM: 4-243/272.0
SDYINASFIHGYdGT---PRSFIASQGPLPPAFEGFWRMvWEQNSQSIVMLTNLVELGKTKCHKYWP-------------DKTETYGGVTVTLHQSEIFA
|.||||... || |    |. ...|.||||   ..|||. .|..  .||.|....|.|. ||..|||             . | .|| ..|||.. |.. 
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DYEIRTFILSKA-KRSGSRMVRQFHFTVWPDKGVPQYAtaVLAFRRKVRAlnprdAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVD--------IR
|| .|...|..  . . .|.|...|.| ||| |||| |  .|.. . ...      |||.||||||..||| ..... .|..  ..  ||        ..
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

NYLIALRKDRPHMVQTKEQYSFIHSAVLEAlTCGNTEIQSENYNQAMQKL
...  ||. ||..||| ||| |.. |.||.  .. .... | ...|.. .
eaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldai

0036282 (Phosphotyrosine protein) phosphatases II 36-234 1.5e-46 153.6 In-house 2-163 (174) alignment
Range on Protein: 36-234
Range on HMM: 2-163/174.0
SDYINASFIHGYDGTPrSFIASQGPLPpafegFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDktetyggvtvtlhqseifadyeirtfilskAKRSG
|||||||.....  ||  .||.||||.     ||.|..|......|||....|||..||. |||.                               . . 
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredl

SRMVRQFHFTVWPDKGVPQYATaVLAFRRKVRALNPR-DAGPVIVHCSAGVGRTGAYIVIDAMLEQAKkSRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
.|.. |.... ||| |||  .. .| | . |.    . . |||.|||||||||||. .... || . . ...||. ... .||. ||.|||| .|| |..
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly





0049260 (Phosphotyrosine protein) phosphatases II 51-234 1.2e-39 130.7 In-house 8-143 (152) alignment
Range on Protein: 51-234
Range on HMM: 8-143/152.0
PRSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWpdktetyggvtvtlhqseifadyeirtfilskakrsgsrmvrQFHFTVWPDK
|. ||| |||.|  .. ||||..|.. . |||||.|.|||| ||..|.                                          |.... ||| 
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDh

GVPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLeqakksRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
|||. .  .| . . .. |. .. |||.|||||||||||...... ||      . |.. ...  .|. ||..|....|. |..
gvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 52-234 2.2e-23 77.5 In-house 5-197 (199) alignment
Range on Protein: 52-234
Range on HMM: 5-197/199.0
RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD---KTETYGGVTVTLHQSEIFADYEIRTFILSKAKR--SGSRMVRQFHFTV
| .||.| ||  ..  ||.||||  |  |||. .     ..    |||     |  || ..|| .     .|| | ..||..       .| . .. || 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPQYAT---AVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRT--VDIRNYLIALRKDRPHMVQTKEQYSFIH
| .|  |. |     |.| |   .  .     ||||||| | | || .. .|  .   ..|.|  ||. .    ||. |  .. . ..| ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 52-234 2.4e-23 77.4 In-house 4-196 (198) alignment
Range on Protein: 52-234
Range on HMM: 4-196/198.0
RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPD---KTETYGGVTVTLHQSEIFADYEIRTFILSKAKR--SGSRMVRQFHFTV
| .||.| ||  ..  ||.||||  |  |||. .     ..    |||     |  || ..|| .     .|| | ..||..       .| . .. || 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKGVPQYAT---AVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRT--VDIRNYLIALRKDRPHMVQTKEQYSFIH
| .|  |. |     |.| |   .  .     ||||||| | | || .. .|  .   ..|.|  ||. .    ||. |  .. . ..| ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 52-128 3.4e-08 27.2 In-house 236-311 (440) alignment
Range on Protein: 52-128
Range on HMM: 236-311/440.0
RSFIASQGPLPPAFEGFWRMVWEQNSQSIVMLTNLVElgkTKCHKYWPDKTE--TYGGVTVTLHQSEIFADYEIRTFIL
 .|||.| ||  .   |||.| . .  .|.|| .| .     |  ||| .|   |.|  ||  . || .    .||. |
nafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlel

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 64-248 4.9e-21 69.9 In-house 40-227 (255) alignment
Range on Protein: 64-248
Range on HMM: 40-227/255.0
AFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKTETYGGVTVTLHQseIFADYEIRTFILS-K-AKRSGSRMVRQFHFTVWPDKGVPQYATA
. . |....  .... .|||... | |. ||..|.|   |.   .  |.||  .    ||  .||  .  . ...   . |. .... |..|  |. |  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

VLAFRRKVRalnprDAGPVIVHCSAGVGRTGAYIVIDAM----LEQAKKSRTVDI--RNYLIALRKDRPHMVQTKEQYSFIHSAVLEALtCGNTEI
.|   . ||     |. .|.||||.|.||. |..... .    . . ... ||..  .. |  ||. |.  ..|  | .|    ||. .   ..|.
ilnilkvvr.....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv.fpkgel

subfamily_hpo-7_pd Subfamily hpo-7 64-276 2.1e-18 61.2 In-house 46-260 (263) alignment
Range on Protein: 64-276
Range on HMM: 46-260/263.0
AFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWP---DKTETYGGVTVTLHQSEIfaDYEIRTFILSK--AKRSGSRMVRQFHFTVWPDKGVPQYATA
. . |....  .... .|||..  | |. || .|.|   |.   .  |.|.  ..    |  ..|  | .   ..   . |... .. |..|  |. |  
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelare

VLAFRRKVRalnprDAGPVIVHCSAGVGRTGAYIVIDA----MLEQAKKSRTVDI--RNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQSEN
.|   . .|     .  ...||||.|.||. |. |..     |. . ... ||..  .. |  ||. |.  ..|  | .|    ||. .   ... . | 
ilnilkvar.....nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgelea

YNQAMQKlaSVNRKFQMTGYALEF
  | ..|  |  .  ||    |||
kyqeirk..sylharqmmhkdlef

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 64-241 1.6e-17 57.9 In-house 103-288 (302) alignment
Range on Protein: 64-241
Range on HMM: 103-288/302.0
AFEGFWRMVWEQNSQSIVMLTNLVELGKTKCHKYWPDKTE---TYGGVTVT---LH-QSEIFADYEI---RT--FILSKAKRSGSRMVRQFHFTVWPDKG
. | .| .. . |   .| |...|| .. || .|. || .   ..|  ||.   .. . | |.| .     |  .  .| |.   . |  ..|. |||.|
tlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhG

VPQYATAVLAFRRKVRALNPRdagpVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
 |. | . |   .   .        |.|||||||||||. . |   ..  .| .. |. . .. .|. |   ||...|  ..   |  .|
apkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkgl

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 88-234 2.9e-08 27.6 In-house 144-295 (332) alignment
Range on Protein: 88-234
Range on HMM: 144-295/332.0
ELGKTKCHKYWPDKTETYGGVTVTLHQSEIFADYEIRTFILSKAKRSGSRMVRQFHFTVWPDK-GVPQYATAVLAFRR--KVRALN--PRDAGPVIVHCS
||    |.|.||.|.      ..... |. ...  ..|| |. ...   .    .||  | |   .|.|   . |  .   .|. .      ||... |.
elkakicrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvca

AGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
.|| .   .  || .. .  . . | ... . |.. .|   ..|   ||   
tgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystac

0048076 (Phosphotyrosine protein) phosphatases II 105-238 2.4e-25 84.3 In-house 13-140 (145) alignment
Range on Protein: 105-238
Range on HMM: 13-140/145.0
YGGVTvTLHQSEIFADYEIRT-FILSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDaGPVIVHCSAGVGRTGAYIVIDAMLEqakk
.|... | .. | ..|. |.| . |.  ..  .|.. |.... ||| |||. .  .|.| . .... ... |||.|||||||||||...... ||.    
lgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....

sRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVL
 . |.. . |  .|. ||..|.. .|. |.. ..|
.lgvsleealelvrsqrpgavpnpgqlrflyefel

0048179 (Phosphotyrosine protein) phosphatases II 119-235 4.6e-24 80.2 In-house 26-139 (144) alignment
Range on Protein: 119-235
Range on HMM: 26-139/144.0
ADYEIRTFI---LSKAKRSGSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDaGPVIVHCSAGVGRTGAYIVIDAMLeqakkSRTVDIRNYLIA
... |.| |    .  . .  |.. |.... ||| |||.... .|.| . .... ... |||.|||||||||||...... |.      . ... . |  
kklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealal

LRKDRPHMVQTKEQYSFIHS
.|. ||..|.. .|. |.. 
vrsrrpgavpnpgqlrfLle

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 135-275 1.4e-33 110.8 In-house 87-228 (440) alignment
Range on Protein: 135-275
Range on HMM: 87-228/440.0
GSRMVRQFHFTVWPDKGVPQYATAVLAFRRKVRALN-PRDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFI
 || ..|.|.  |||||||..|  || . . |   .     ||..||||||.||||  |..|..| .||.|  .|| ... ..|..||.|||| |||.|.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HSAVLEALTCGNTEIQSENYNQAMQKLASVNRKFQMTGYALE
| ||||.| ||.| |  ..  . ....   | . . .    |
heavlegllcgdtliledditerveqiqwpnphtdksplqqe

PTPc_DSPc_SM00012 139-239 2.5e-33 109.8 In-house 2-105 (105) alignment
Range on Protein: 139-239
Range on HMM: 2-105/105.0
VRQFHFTVWPDKGVPQYATAVLAFRRKVRALNPRDA--GPVIVHCSAGVGRTGAYIVIDAMLEQAKKS-RTVDIRNYLIALRKDRPHMVQTKEQYSFIHS
|...|.| |||.|||......| . |.|.  .   .  .||.||||||||||| ....| .|.| .|. ..||| ... .||| ||.||||.|||.|.. 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle

0038934 (Phosphotyrosine protein) phosphatases II 142-234 2.6e-07 26.0 In-house 82-170 (194) alignment
Range on Protein: 142-234
Range on HMM: 82-170/194.0
FHFTVWPDKG-VPQYATAVLAFRRKVRALNPRDAGPVIVHCSAGVGRTGAYIVIdAMLEqakkSRTVDIRNYLIALRKDRPHMVQTKEQYSFIH
..   .||.| ||....    ..   . ||    | | ||| ||.||||  ..  ....    ..  . .  .  .|  ||..... .... ..
ylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa.YLiy....rlgmsaeeAialfrekRpgaipnqdyleall

subfamily_PTPDC1_pd Subfamily PTPDC1 145-234 5.1e-08 27.5 In-house 88-169 (182) alignment
Range on Protein: 145-234
Range on HMM: 88-169/182.0
TVWPDKGVPQYATAvLAFRrKVRALNPrDAGPVIVHCSAGVGRTGAyiVIDAMLEQAKKsrtVDIRNYLIALRKDRPHMVQTKEQYSFIH
  |.| ||.   .. |    || |    . | | ||| || ||||   .| ..|  ||.   ..  . .  .|. ||. .||.||  ...
fgwkDygvasleri.Ldiv.kvvafal.qegkvavhChaGlGrtGv..liacylvyakr...ltaekaiklvrskrpksiqtreqvelvk

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 164-241 1.2e-17 58.7 In-house 219-295 (297) alignment
Range on Protein: 164-241
Range on HMM: 219-295/297.0
RKVRALNPRDAgPVIVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEAL
  .||  ||.| ...|||||||||.|  .  |..|.. .| |  |..  |  ||. |. .||| ||. ....|||. |
eslraemprna.yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl

subfamily_CG42327_pd Subfamily CG42327 172-236 2.3e-17 57.7 In-house 245-310 (319) alignment
Range on Protein: 172-236
Range on HMM: 245-310/319.0
RDAGPVIVHCSAGVGRTGAYIVIDAMLEQAKKS-RTVDIRNYLIALRKDRPHMVQTKEQYSFIHSA
 . ||..|||| ||||||  |  |  ... ..| |.||| . .  .|.|| . |.||||| ||.  
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 172-238 2.5e-13 44.5 In-house 260-341 (350) alignment
Range on Protein: 172-238
Range on HMM: 260-341/350.0
RDAGPVIVHCSAGVGRTGAYIVIDAMLE-------QAKKSRTVDIRN--------YLIALRKDRPHMVQTKEQYSFIHSAVL
  . |..||||||||||| .. .| .|.         |.|| .|  .         .  ||| |  |||...|. ||. |.|
arsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 172-239 1e-08 28.9 In-house 263-342 (349) alignment
Range on Protein: 172-239
Range on HMM: 263-342/349.0
RDAGPVIVHCSAGVGRTGAYIVIDAMLE----QAKKSRTVDIRNY-------LI-ALRKDRPHMVQTKEQYSFIHSAVLE
 .  ...|||||| |||| .. .| .|.      ..|  .....         .  ||| |  |||   |. .|. |.|.
dqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk

subfamily_eak_pd Subfamily eak 175-250 1.4e-10 35.1 In-house 238-314 (332) alignment
Range on Protein: 175-250
Range on HMM: 238-314/332.0
GPvIVHCSAGVGRTGAYIVIDAMLE--QAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCGNTEIQS
 | |. .. |  |.|...||| ...  ..||  .  . ....  .. | | | .. |.|||. .||. |   | ... 
ap.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrd

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 178-244 9e-17 55.2 In-house 2-68 (69) alignment
Range on Protein: 178-244
Range on HMM: 2-68/69.0
IVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCG
.||||.| ||||..| |   . . |  . ||| | .  .|| || ||  . .| ||| |. |||  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 178-244 1.4e-16 54.6 In-house 1-67 (69) alignment
Range on Protein: 178-244
Range on HMM: 1-67/69.0
IVHCSAGVGRTGAYIVIDAMLEQAKKSRTVDIRNYLIALRKDRPHMVQTKEQYSFIHSAVLEALTCG
.||||.| ||||..| |   . . |  . ||| | .  .|| || ||  ...| ||| |. |||  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG

0050432 (Phosphotyrosine protein) phosphatases II 235-538 1.3e-87 289.3 In-house 6-306 (308) alignment
Range on Protein: 235-538
Range on HMM: 6-306/308.0
SAVLEALTCGNTEIQSENYNQAMQKLAS-VNRKFQMTGYALEFQRLNSVTSreipAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLhkehaDEESDYINA
.|.||.|....|.|. ..... ...|.  ..........  ||..|.||.      .| ||...|.| .|||..||... ..|| |     ||.||||||
dallelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp....lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInA

VFLHVR--MERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHD-QEYPQYLPVE---GATKYGHIRVSLLSKQEKGDVISTKLKVTR--NKKT
 . ..     ...|||||.||..|.||||||| .... .||||..|.| . . ..|| | |   | ..||...| ||| ....|.. ..|..|   ....
syvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges

HEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQqqcGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQ
..|.|.|. .||| ..|. ....||.|..|. |.   .. |..| ||.||||.|||.|.  ..|.|..|. .|||...|..|  |||.|... ||.|.|.
rtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyr

IIQKYLDSFSDYA
....|| ..  ..
alleylklkltkl

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 236-431 3.7e-14 46.9 In-house 34-224 (244) alignment
Range on Protein: 236-431
Range on HMM: 34-224/244.0
AVLEALTCGNTEIQSENYNQAMQKLASVNRKFQMTGYALEFQRLNSVtSREIPAEEKSVgEKPQNLHKNRFSDIIALNSCRVMLHKEHAdeESDYINAVF
||| | .. |  |.   ....   |.| ...      |   |  ...  |  |.  | .  .|.| .||| .  . ..  || | |        |||| |
avlsanatknryinilpfdetrvilssskkegsdyinanyiqgsqni.irpdpsvmkda.fnpnnswknregaglpfdfnrvplskgsm..gntyinasf

LHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEYPQYLPVEGATKygHIRVSLLSKQEKGDVISTKLKVTRN-KKTHEVRHL
.        .| |||||  |  |||.|. .  .  .|.|  . | |. .|.  |.|   .   | |.|  ..|  .. ...|..  . ...|.   .
vgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeedeywpdseplewyee..ditvtltdrdefknikasnleiesdmneshqaltm

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 244-538 4.6e-144 474.2 In-house 1-297 (298) alignment
Range on Protein: 244-538
Range on HMM: 1-297/298.0
GNTEIQSENYNQAMQKLASVNRKFQMTGYALEFQRLNSVTSrEIPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERN
|||||..|....|.||||.|..|...|||||||||||||.| ||..|||.|..||.| .|||..|||||.|.||.|.||.||||||||||.|||   .||
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvss.eieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn

AFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQ-EYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTRNK--KTHEVRHLHHVSWPDKC
||||||.||..|.||||||||..||||||||.||.|.|. .|..| | ||...||.|.||||||.|..|.|..||||...|  |..|||.||..|||||.
afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkg

IPEVARSVLDLLDEVQASQQQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSFSDYA
.||.|.||||||..|.|||||.||.||.||||.||||||||.||.||.||.|.|||.|||||.|..|..|||||.. .||||.|......||||.|..
vpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

0051299 (Phosphotyrosine protein) phosphatases II 244-531 2e-84 278.7 In-house 1-286 (288) alignment
Range on Protein: 244-531
Range on HMM: 1-286/288.0
GNTEIQSENYNQAMQKLAsvnrKFQMTGYALEFQRLNSVTSReipaEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERN
|.|||. |.. ....||     . ..||.. ||..| |..       . |.. .|.||.|||.|||......|| |. .. .|.|||||| ....    .
gdteisveellklvlkll....angltglleefeellsllpd....ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkr

AFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHD-QEYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVT------RNKKTHEVRHLHHVSW
.|||||.||..|.||||||| .... .||||..|.|.. . ..|| | .| ..||.|.| ||| ....|.. ..|.||       ......|.|.|. .|
kfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnw

PDKCIPEVARSVLDLLDEVQASQQqCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
|| ..|. ....||.| .|. ...  |. ||.| ||.||||.|||.|.  ..|.|..|...||....||.|  |||.|... ||.|.|...  ||
pdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_PTPN6_pd Subfamily PTPN6 246-533 3.1e-58 192.2 In-house 2-299 (306) alignment
Range on Protein: 246-533
Range on HMM: 2-299/306.0
TEIQSENYNQAMQKLASVNRKFQMTGYALEFQRLNSVTSREIpaEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHkEHADEESDYINAVFLH--VRMERN
|.. ... .| ...|   . ... .|.  ||..|.   ...    ... |.||.| .|||.  |.  .  ||.|. |.   .|||||| ...  |. ...
tsllakeieqrvselekeeeslekagfeeefeelqqeeakkl..lsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdk

AFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQ-EYPQYLPVEGA-TKYGHIRVSLLSKQEKGDVISTKLKVT---RNKKTHEVRHLHHVSWPD
..||||  |..|..|||||| . .   |||. .  |. .    .| | | . ..||.|.|. .|.... | |  .|.|.   ..|...||...|. ||||
syiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPd

KCIPEVARSVLDLLDEVQASQQQCG---NAPVLVQCSNGVGRSGTFCAISSVIERLKT---EQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLD
. .|.    |||.|..|.. |...    . |..| ||.|.|| |||  |  ... ...   .  ||. ...| .|. | | |   .|| | |..|.||..
hgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie

S
.
t

subfamily_PTPRB_pd Subfamily PTPRB 247-532 2.4e-65 215.5 In-house 6-286 (293) alignment
Range on Protein: 247-532
Range on HMM: 6-286/293.0
EIQSENYNQAMQKLASVNrkfqMTGYALEFQRLNSVTSREipaeEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFI
.|. |.... ..|... .     .... |...|..| . .    .... |...|  |||...|.. .  || |.. . ...|||||| ...    .. ||
piklekfeehvkkmkads....dlrfseeyeelkavgkdq....avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefi

ATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQ-EYPQYLPVE-GATKYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEV
||| || .|..|||||| .    .|||| .| |. .    .| | .  .. ||.|.|.|....|. | .  .||....|....||..|..||||  .|| 
atqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPek

ARSVLDLLDEVQASQ-QQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLD
....||.. .|. .. ... ..|..| || ||||.||| |.  .......|...|.| .. ..| .|   | . .||.| .| ....| 
tktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 253-525 3.4e-28 93.1 In-house 10-284 (310) alignment
Range on Protein: 253-525
Range on HMM: 10-284/310.0
YNQAMQKLASVNRKFQMTGYALEFQRLNSVTSREIPAEeksvgEKPQNLHKNRFSDIIALNSCRVMLHKEHADeESDYINAVFLHVRMERNAFIATQHPL
| .|....     |. . | . ....|..     .  |        ...||||.||.. |...|| |. ...    ||| | ...    |..|| .| ||
ylkalenfiiateklgieglvkqyrkldakqdssltye.....aykkymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrstficsqgpl

QHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEY-PQYLPVEGATK-YGHIRVSLLSKQEKGDVIStKLKVT------------RNKKTHEVRHLHHVSWPD
|||| |||||. .    .|..| .  |  .     | |  | |. || |||. ||.  .   |  .| ||             | |   |  ..   |||
qhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeic.nlavtfvpdnvpvdeqpanlkelrvslikwpnwpd

KCIPEVARSVLdlldeVQASQQQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQ
. .|.     .      |    |    |..|.|| |..| .. .|.   |..|.  . .|. .|.  .. .|   ...  ||..  .
rgvpdekchtv.....pqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidr

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 254-532 2.6e-40 132.9 In-house 11-284 (290) alignment
Range on Protein: 254-532
Range on HMM: 11-284/290.0
NQAMQKLASVNRKFQMTGYALEFqrLNSVTSR-EIPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKehaDEESDYINAVFlhVRMERNAFIATQHPL
 .|..|.||   | .. ..| |.  |. .         |... .|  ...|||. |..  .  ||.|.      . ||. | .  |.  .  || || .|
teafekfasdvvkknvdelakey..leklkpylpvqylerkifdkntefkknrykdvvcndktrvilkd...GydGdyvhany..vkGlkamfiltqGal

QHTIEDFWRMVTDYDIGTIVMLNNLHEHDQE-YPQYLPV-EG-ATKYGHIRVSLLSKQEKGDVISTK-LKVT--RNKKTHEVRHLHHVSWPDKCIPEVAR
. |. |.|||| . .. .|||| .| |. .    || |  || .  .|.| |    ...| . |  | | |    . | | ..||. .|||||...  . 
kdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstl

SVLDLLDEVQasqQQCGnaPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLD
..| .|  ..   .  |  || | || |.||.||| ||   .. |   . .|. .... .|  | ..|.  .||.   .|. ..  
allrtlrilr...kasG..pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGk

0039614 (Phosphotyrosine protein) phosphatases II 260-534 2.9e-80 265.2 In-house 22-292 (297) alignment
Range on Protein: 260-534
Range on HMM: 22-292/297.0
LASVNRKFQMTGYALEFQRLNSVTSreipaEeKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHA-DEESDYINAVFLHVRME-RNAFIATQHPLQHTIE
|  .......|.. |||..| |..      . .|....|.| .|||..||......|| |. |   |..|||||| .. .     ..|||||.||..|.|
llllekansktllllefeellslkp.....d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetve

DFWRMVTDYDIGTIVMLNNLHEHDQEYPQYLPVEGAtKYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQA
|||||| .... .||||..| |... ..|| | ||  .||...| ||. ....... ..|.||.|.....|.|.....||| ..|. ....|..|..|. 
dFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvre

SQQQC-GNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSF
 .... .. |||| ||.||||.|||.|.  ..|.|..|. .||....|..|  |||||... ||.|.|......|  .
alaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 260-540 1.9e-65 215.7 In-house 10-287 (287) alignment
Range on Protein: 260-540
Range on HMM: 10-287/287.0
LASVNRKFQMTGYALEFQRLNSVTSREipaEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHkehaDEESDYINAVFLHVRMERNAFIATQHPLQHTIEDF
..  ...   .|.   |. |..|| ||   .|  ..  .|| .|||...|.  .  ||.|.    .|. |||||||.    |..|||... |. .|. .|
fvakghakgnegfknqftvleqvtqre...devthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnf

WRMVTDYDIGTIVMLNNLHEHDQEY-PQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTRNKK---THEVRHLHHVSWPDKC-IPEVARSVLdLLDE
|... |  . .|||| ...|.|.|   || | | .. .|. ...||... . ..|  ||.|....|   ...|.  .  .|...  ..| . ..| ...|
WkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill.viee

VQASQQQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSFSDYANF
   .|.. ||....| ||..||||..|||.   |.. ||| |||||||.|. |  .||.|   .|| | ..|...|||||. |..|
myktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf

0049772 (Phosphotyrosine protein) phosphatases II 260-534 1.6e-43 145.0 In-house 6-283 (314) alignment
Range on Protein: 260-534
Range on HMM: 6-283/314.0
LASVNRKFQMTGYALEFQRLNSVTSREIPAEEKSVGEKPQNLHKNRFSDIIALNsCRVMLHKEHADEeSDYINAVFLHVRmerNAFIATQHPLQHTIEDF
|||...  ..  .  ....||... . .|.    |. .. | .|||. ||.  . .||.|.... .  |||||| ...     ..|||||.||..|..||
lasfsellihddllklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdf

----------WRMV--TDYDIGTIVM---------------------LNNLHEHDqeypqylPVEGATKYGHIRvsllskqekgdvistklKVT--RNKK
          ||||   |... .|||                     |..| ..        .   |  . ...                 ...  ... 
reepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.......neptaadlellk.................eelydpelf

THEVRHLHHVSWPDKCIPeVARSVLDLLDEVQASqqqCGNAPVLVQCSNGVGRSGTFCAISSVIERLKteqViDVFQVIKRIRANRP-----GAVESLTQ
.... ..... .|| . |   . ....|. ...      . |||| |. |.||.|||...  .. .|.   | .. ......|. ||     |..|.| |
erlgikylripvpDgsap.lledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg...v.sleealedvrlkRpinpnpgfieqleq

YVFCYQIIQKYLDSF
|.|.......||. .
yefilealleylkfl

0036941 (Phosphotyrosine protein) phosphatases II 262-531 1.9e-78 259.1 In-house 5-277 (297) alignment
Range on Protein: 262-531
Range on HMM: 5-277/297.0
SVNRKFQMTGYALEFQRLnsvtSREIPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLhkehADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWR
 ..........  ||..|     . ..  ..||...|.||.|||..||......|| |     ||.|||||| .. .    ..|||||.||..|.|||||
llekllflalllkefeel....lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWr

MVTDYDIGTIVMLNNLHEHDQ-EYPQYLPVE--GATKYGHIRVSLLSKQE--KGDVISTKLKVTR--NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDE
|| .... .||||..| | .   ..|| | |  .  .||...| ||| ..  ..|.. ..|.||   |.....|.|.|. .||| ..|| ..|.||....
mvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfiel

VQASQQQC-GNAPVLVQCSNGVGRSGTFCAISSVIERLK---TEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
|.  ...  .. |||| ||.||||||||.|.  ....|.   .|. .|.....| .|  |||||..| ||.|.|......|
vrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

0047943 (Phosphotyrosine protein) phosphatases II 263-531 5.6e-78 257.5 In-house 5-272 (273) alignment
Range on Protein: 263-531
Range on HMM: 5-272/273.0
VNRKFQMTGYALEFQRLNSVTSreipAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLhkehADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRM
.......|....||..| |..       ..||...|.|..|||..||......|| |     |..|||||| .. .    ..|||||.||..|.||||||
lekllgltllleefelllslkp....lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrm

VTDYDIGTIVMLNNLHEHDQ-EYPQYLPVEG---ATKYGHIRVSLLSKQEKGDVISTKLKVTR--NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQ
| .... .||||..|.| ..  ..|| | ||    ..||...| ||| ..|.|.. ..|..|.  ......|.|.|. .||| ..|.   |.|.....|.
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

ASQQQC-GNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
  .... .| ||.| ||.||||.|||.|.  ....|..|. .||....|..|  |||.|... ||.|.|... .||
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 263-533 9.6e-60 197.1 In-house 8-278 (281) alignment
Range on Protein: 263-533
Range on HMM: 8-278/281.0
VNRKFQMTGYALEFQRLNSVTSREIpAeekSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRM
 ... . .|.. |.. |...  ..  |   .  ....| .|||.|.|.| .  || ..........||||| |.    . ...|||| |. .....||.|
qlsqndnaGfieeyeklaaigvdnt.a...taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

VTDYDIGTIVMLNNLHEHDQ-EYPQYLPVEG-ATKYGHIRVSLLSKQEKGDVISTKLKV-TRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQ
| .... .|||. .  | ..    .| | .  ..|||...|. ....||   |. |.|. ... .| ||..|....|||. .|. .. .|.  .||.  .
vweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlklt

QQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTE-QVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDS
..  .||... || ||||.||. |.  .......| . .|| .|.. .| .|   | ...|| | |... ..|| 
ekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 264-537 5.3e-64 210.9 In-house 14-289 (290) alignment
Range on Protein: 264-537
Range on HMM: 14-289/290.0
NRKFQMTGYALEFQRLNSVTSReipaEEKSVGEKPQNLHKNRFSDIIALNSCRVMLH--KEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWR
... ...|.  .|..|.|  |     ..  ||  ..| ..|||..|.  .  |..|.   .| | . .||||....   |....|||| |...|. |||.
ghakgnegfrnqfkmldsgese....htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWk

MVTDYDIGTIVMLNNLHEHDQE-YPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTRNKK---THEVRHLHHVSWPDKCIPEVARSVLDLLDEVQA
.. . ..  |||| |  |....   || | .....||.... ||. ..  . | .||.|. ...   ...| ...  .|...   .   ..| .. |.. 
liwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk

SQQQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSFSDY
 | . || ...| ||..||||..|||.   |.. |||.|||||||.|. |  .|| |..  || . .||. .|||||. |
tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 264-537 1.3e-58 193.8 In-house 26-298 (319) alignment
Range on Protein: 264-537
Range on HMM: 26-298/319.0
NRKF--QMTGYALEFQRLnsvTSREIPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWR
...|  ..| .  ||.|.   . . ..  ...  . .||  |||. .|.| .  .| |..    | |||||| |.     .. .||.| ||. |..||||
ksdfdddltklevefrra...cklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWr

MVTDYDIGTIVMLNnlhehDQEYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTR---NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQ-A
|. .|.. |||.|       .   || | ..  |...  |.. | .|  . .  ......   .|   ...  |   |||.  |. .  .. |.. |.  
miweyncstivllt.....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhl

SQQQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQ-KYLDSFSDY
 ... ..|...| || ||||.|.. ..  ...|.| |. .||..... .| .|.  |..|.|| |.|  .  ..| ..|| 
tskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdv

0043336 (Phosphotyrosine protein) phosphatases II 265-531 2.5e-75 248.8 In-house 15-277 (278) alignment
Range on Protein: 265-531
Range on HMM: 15-277/278.0
RKFQMTGYALEFQRLNSVTSreipaEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVT
 .   |.. |||..|.|..      ...|....|.| .|||..||......|| |. .  |. |||||| .. .    ..|||||.||..|.||||||| 
llnlktllllefeellsfkl.....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvw

DYDIGTIVMLNNLHEHD-QEYPQYLPvEGATKYGHIRVSLLSKQEKGDVISTKLKVT--RNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQq
.... |||||..| |.. . . || | .| ..||...| ||. ....|.. ..|.||  .......|.|.|...||| ..||   ..||.| .|.  .. 
elgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.

CGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
  | |||| ||.||||.|||.|.  ..|.|..|. .|.....|..|  |||||... ||.|.|.... ||
dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

0040438 (Phosphotyrosine protein) phosphatases II 266-531 2.2e-79 262.3 In-house 14-276 (317) alignment
Range on Protein: 266-531
Range on HMM: 14-276/317.0
KFQMTGYALEFQRLNSVtsreiPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTD
| ..|.   ||..| |.     . .. ||.|.|.| .|||..||. . ..|| |. .  |..|||||| . ..  ....|||||.||..|.||||||| .
ksdftalleefedllsl.....kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvwe

YDIGTIVMLNNLHEHD-QEYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVT--RNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQqC
.....||||..| | . . . || | .. ..||...| ||| .|..... ..|.|.  .......|.|.|. .||| ..|.  ...||.|..|.....  
qgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.d

GNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
.. |||| ||.||||.|||.|.  ..|.|..|. .||....|..|. |||||... ||.|.|.....||
pggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 267-530 2.2e-72 238.6 In-house 18-278 (288) alignment
Range on Protein: 267-530
Range on HMM: 18-278/288.0
FQMTGYALEFQRLNSVTSReipaEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDY
 . ||.  |.. | .. .     .....|....| .|||. .|....  || |.| .  ...||||| ....  .....|||| ||..|..|||..| ..
rnrtgfseeynsLaalekt....ksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyen

DIGTIVMLNNLHEHD-QEYPQYLPVEGA-TKYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCgN
.. |||||..| | . ..  .| | ..  ..||.. | |....|..|..  || . ..|.  |. .... .|||. .|| .. .|.||. |. ..|.   
ktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.t

APVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKY
 |..|.||.||||.||| |.  .|.....|..|||. .....| .|.  |. |.||.|.|... . 
gpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl

0045450 (Phosphotyrosine protein) phosphatases II 268-531 3.4e-76 252.2 In-house 25-304 (307) alignment
Range on Protein: 268-531
Range on HMM: 25-304/307.0
QMTGYALEFQRLNSVTSREipAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHAD-EESDYINAVFL--------HVRMERNAFIATQHPLQHTIED
 .||.. ||..|.||| .     | |....|.| .|||..||......|| |. .. . |.|||||| .         ..    ..|||||.||..|.||
fltgllkefekllsvtvfl..lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetved

FWRMVTDYDIGTIVMLNNLHEHDQE-YPQYLPVEGAT-KYGHIRVSLLSKQEKGDVISTKLKVT---RNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLD
||||. ......||||..| |...| ..|| | || .  ||...| |||........ ..|.||    ......|.|.|. .||| ..|.   ..||...
FwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfie

EVQASQQQC-GNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQV---IDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
||.. .... .. |||| || ||||.|||.|.  ....|..|..   .|.....|..|. |||||... ||.|.|......|
evrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_CG7180_pd Subfamily CG7180 268-531 2.3e-56 185.6 In-house 11-290 (296) alignment
Range on Protein: 268-531
Range on HMM: 11-290/296.0
QMTGYALEFQRLNSVTSReIPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYD
..  . .|.. .  .|.| .  ..   | . .|. |||  ...  .  ||.|.| . .|.|||||||.    .  ...| |. | ..|...|||.| | .
krrkfrveyklelkltpr.leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydee

IGTIVMLNNLHEHDQEYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTRN------------KKTHEVRHLHHVSWPD-KCIPEVARSVLDLLDE
| ..|.| .  .  . ||.|.| .. ..||.| | ......  .. . ..|.|..             .|  |....   |.  . .| .. ....|.  
isavvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrr

VQASQQQC----GNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
|.  ...      ..||.| .|.|..||| ..||   .| .. |. .|||. .|..| .||. ||. ..| ..|.......
vrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 269-535 2.7e-76 251.7 In-house 22-287 (319) alignment
Range on Protein: 269-535
Range on HMM: 22-287/319.0
MTGYALEFQRLNSVTSReipaeEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDI
.|. . ||. |.  ..      . .  .|..| .|||...|.| . .||.| . .  |.|||||| |.    ||..||||| ||..||||||||| ....
etllekefkllkeavnd.....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeees

GTIVMLNNLHEHDQ-EYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTRNKK---THEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGN
 ..|||..| |. . .. .| | |  ..||.. | |....|. |.|  |||. ...    | || | .. .|||. .|| |.|.|||| ... |...  .
sivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqs

APVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSFS
 |. | ||.|||| |||.... ..||.| |.|.|||....|.|. |.  |.   || |.|... .......
gPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 269-531 2e-64 212.8 In-house 22-288 (325) alignment
Range on Protein: 269-531
Range on HMM: 22-288/325.0
MTGYALEFQRLNSVTSReipaeEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDI
  |.| ||. | |. .       | |  ||.|  |||| ...||.  ||.|   . | .|||||| .|.  .... |.|.| || .||.|.||.| |.  
qdgfahefgllpsddgi.....akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrc

GTIVMLNNLHEHDQEYPQYLPVE--GATKYGHIRVSLLSKQEKGDVISTKLKVTRNKK--THEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQ---
  .|.|| | . ...  .| | |   . ..| ..|.| . .|  | .  .|.| . ||  |  |. ... ||.|   ..   ... .|. |.| ...   
svvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservta

--CGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
   . .|.|| ||.||||.|.| .. |..... .|  .|.|...|..|..||  ||.  ||...|. . ...
ntkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay

subfamily_PTPN23_pd Subfamily PTPN23 269-531 1.1e-54 180.2 In-house 14-280 (288) alignment
Range on Protein: 269-531
Range on HMM: 14-280/288.0
MTGYALEFQRLNSVTSREipAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHkehaDEESDYINAVFLH-VRMERNAFIATQHPLQHTIEDFWRMVTDYD
 |.   .|. |..   .|  |...|.     . .|||. ||.  .. ||.|.    ... ||||| |.. .      ||||| ||| |. |||.|| .  
ktaldkkfkeleqkqdke..arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqk

IGTIVMLNNLHEHDQE-YPQYLPVE--GATKYGHIRVSLLSKQEKGDVISTKLKVTRN--KKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQA---SQ
  .|||| . .| ...   .| | .   ..|.|...|.| |..| . ..  .||.. .  .....|.||.  |||.  .|.   ..|..||||..   ..
ssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeav

QQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTE-QVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
|.  ..|..|.|| ||||.|.|. . .... |...  ..|. ||..|.|..|   |.  .|. |.|... .. 
qrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa

subfamily_Ptp69D_pd Subfamily Ptp69D 270-532 8.5e-71 233.6 In-house 22-287 (307) alignment
Range on Protein: 270-532
Range on HMM: 22-287/307.0
TGYALEFQRLNSVtsrEIPaEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIG
 |.| |...|..    ||.  . .|.||  |. |||. ||.| .. ||.|.|   .|.|||||| |..   |.. ||| | |.. ||.|||||... .. 
fglakeyekLear...eid.kstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevt

TIVMLNNLHEHDQ-EYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTRNK-------KTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQ
.|||| || |... . ..| |.|  ..||.| | | |.....| |  .|.|...|       ....|   |. .|.|  .|||||..|.|...|.  ...
livmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykl

CgNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLD
  ..|..| ||.||||||.| |..|....||.|. .|.|...| .| .|.  |.|| ||||.|. . .| .
n.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

subfamily_PTPN12_pd Subfamily PTPN12 270-532 6.1e-65 214.0 In-house 8-278 (290) alignment
Range on Protein: 270-532
Range on HMM: 8-278/290.0
TGYALEFQRLNSVTSREIPAE--EKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYD
  .| |||.| .....    .  ....|||..| .|||. ||.  .  ||.|.|.. .|.|||||| |..   .. ..||.| || .|..|||||. ...
eefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwekn

IGTIVMLNNLHEHDQEY-PQYLPVE--GATKYGHIRVSLLSKQEKG-DVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQqCG
.  .||. .. | ..    .| | |   ....|...|.| ...    | .   |||...|....|. .|. .|||. .|. | |.|.|...|.  |.   
veivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.se

NAPVLVQCSNGVGRSGTFCAISSVIERLKTEQV---IDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLD
.||..| || |||| || .||  | | ||.|..   .|||... ..| .|. .| .  ||.. |. . ... 
daPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

subfamily_PTPRG_pd Subfamily PTPRG 270-533 1.1e-62 207.1 In-house 19-289 (563) alignment
Range on Protein: 270-533
Range on HMM: 19-289/563.0
TGYALEFQRL-NSVTSREIPAEEksvGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEES-DYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYD
.|.. ||. | . ..|....||     .||.| .||| ..|.| .. || |..    ... ||||| ...     .||||||.||..|..|||||. .  
igfseefealqsetiskdldaeh...sqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

IGTIVMLNNLHEHDQ-EYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTR-------N-KKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQAS
  .|||. || |. . . ..| | ... .||...| | ... .    . .|..         . .. ..||. |  .|||.. || .  ||      .|.
vaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaa

QQQcGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDS
...    |..| ||.||||.||.............|....||...|.|||.|.  |..  ||.| ...... . |
nka.eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 270-527 4.1e-52 171.8 In-house 6-262 (283) alignment
Range on Protein: 270-527
Range on HMM: 6-262/283.0
TGYALEFQRLNSVTsreIPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHAdeesDYINAVFLHVRM---ERNAFIATQHPLQHTIEDFWRMVTDY
... | ...|. ..   .|  .  .    .| .|||. .|.. .  || |. |      |||||||. |     . . .|..| ||..|. |||.|| | 
nnnklfrevlkrls...vpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfde

DIGTIVMLNNLHEHDQE-YPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTRN---KKTHEVRHLHHVSWpDKCIPEVARSVLDLLDEVQASQQQC
.| .|||| .| |  ..   || | .|. .||   |.|     .   |  .| .  |   |.|  . |   . |  .. ..     |  .. |.. |.. 
kitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW.leygeqaiinslvkfnkvislqtes

GNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQII
 ..|..| ||.|.||...|.|.|. .. ..|| |.|||.|.| .| .|..|| .| || . ....
kkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv

subfamily_PTPN13_pd Subfamily PTPN13 270-532 3.8e-47 155.9 In-house 11-270 (273) alignment
Range on Protein: 270-532
Range on HMM: 11-270/273.0
TGYALEFQRLNSVTsreiPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHAdeesdYINAVFLHVRMERNA--FIATQHPLQHTIEDFWRMVTDYD
   | ||. |. .     | .. .||.| .| .|||. ...  .  || | .| .     |||| ...|... .   .||.| || .|..|||.|| . .
qqPaeefkelrelk....pldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqk

IGTIVMLNNLHEHDQ-EYPQYLPVEGA---TKYGHIRVSLLSKQEKGDVISTKLKVTR--NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQq
   |.|. .  |...    .| |..     . .. ..|.||  |.. .    .|.|.    ....|| ||. |.|||  .|  | ..| .. ||.  |. 
aeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.

cGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLD
  ..|..| || |.|||||. .|  |.. .. .. .|| ......|  | | | .  ||.|.|..| . | 
.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

0046845 (Phosphotyrosine protein) phosphatases II 274-538 3.3e-81 268.1 In-house 4-281 (284) alignment
Range on Protein: 274-538
Range on HMM: 4-281/284.0
LEFQRLNSVTSREIpaEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHAD-EESDYINAVFLHVR-----MERNAFIATQHPLQHTIEDFWRMVTDYD
 ||..|.|.|   .   . ||. .|.||.|||..||......|| |. .. | |.|||||| ....      . ...|||||.||..|.||||||| ...
eefeellsltvkll..lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

IGTIVMLNNLHEHDQ-EYPQYLPVEG-ATKYGHIRVSLLSKQEKGDVISTKLKVTR---NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQ-
. .||||..|.| ..  ..|| | ||   .||...| |||...|.|.. ..|..|.   ......|.|.|. |||| ..|. ....|..|..|. .... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

CGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQ---VIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSFSDYA
 |. |..| ||.||||.|||.|.  ..|.|..|.   ..||....||.|  |||.|..| ||.|.|.... || ..  ..
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 275-538 2.7e-77 254.9 In-house 25-287 (318) alignment
Range on Protein: 275-538
Range on HMM: 25-287/318.0
EFQRLNSVtsREIPAEEKSvgEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVML
|..||. .  .| ... ||   .| | .|||. .|.| ...|| |.. . .|.|||||| ..   ....|.||.| || .||||||||| . .  .||||
eyerlsrs..eetvtslks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivml

NNLHEHDQ-EYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTRNKK--THEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGNAPVLVQC
 ...|. .    .| | .|...||...| | .. | .| .  ..||||...  . .||  |. ||||. .|| . |.|||. .|.. ||..|. |..| |
tqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhC

SNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSFSDYA
| |||| |.|.|.....||.| |...||||..|..| .|.  |    ||.|.|......| |.  ..
saGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev

DSPc_SM00195 275-531 4.8e-76 250.9 In-house 5-262 (263) alignment
Range on Protein: 275-531
Range on HMM: 5-262/263.0
EFQRLNSVTSREipaeEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVML
||..|.. || .    |.. .||..| .|||...|.  .. || |.||. .|.|||||| .. .  .....||||.||..|.|||||||.. .. .||||
efekleestspk....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NNLHE-HDQEYPQYLPVE--GATKYGHIRVSLLSKQEKG-DVISTKLKVTRNK--KTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCgNAPVL
..  | . ..  .| | |  | ...|.|.| | ....|  ..| ..|..| ..  .|..|..... .|||. .|. ..|||.|| .|. |...  ..|..
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
|.||.||||.|||..|......|..|. .|.|...|..| .|||.|..|.|| |.|..| .|.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 275-531 4.8e-76 250.9 In-house 5-262 (263) alignment
Range on Protein: 275-531
Range on HMM: 5-262/263.0
EFQRLNSVTSREipaeEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVML
||..|.. || .    |.. .||..| .|||...|.  .. || |.||. .|.|||||| .. .  .....||||.||..|.|||||||.. .. .||||
efekleestspk....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NNLHE-HDQEYPQYLPVE--GATKYGHIRVSLLSKQEKG-DVISTKLKVTRNK--KTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCgNAPVL
..  | . ..  .| | |  | ...|.|.| | ....|  ..| ..|..| ..  .|..|..... .|||. .|. ..|||.|| .|. |...  ..|..
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
|.||.||||.|||..|......|..|. .|.|...|..| .|||.|..|.|| |.|..| .|.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 275-530 1.2e-46 153.9 In-house 11-258 (267) alignment
Range on Protein: 275-530
Range on HMM: 11-258/267.0
EFQRLNSVTSREIpAEEKSVGEKPQnlHKNRFSDIIALNSCRVMLHKEHADeesdYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVML
||. .. ... .     .|..|| |   .||. | .  .  ||.| ..  .    |||| ...    .||||.|| ||. || ||. ...|... .||.|
efelikkisdtss.tisqsiaeknq..ernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

NNLHEhdQEYPQYLPVE--GATKYGHIRVSLLSKQEK--GDVISTKLKVtRNKKTHEVRHLHHVSWPdkcIPEVARSVLDLLDE-VQASQQQCGNAPVLV
 .  .  .. ... | .   | ||  . |    ..|.   ..|. .||. .|. .|.|   ..  |    |    .  |  |   .   | . || |..|
tkvft..dnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkf.knesahnvtlyyykkwn...intnnkpylkplfgilaknqlengnrPlvv

QCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKY
.||.||||||||  | | .||.|||.| |.|. ...||  |.| |... .|....... .|
acsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey

subfamily_eak_pd Subfamily eak 278-444 6.7e-14 46.0 In-house 28-197 (332) alignment
Range on Protein: 278-444
Range on HMM: 28-197/332.0
RLNSVT--SREIPAEEKSVGEKPQNLHKNrFSDIIALNSCRVMLHKEHADeESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVML-
|.| |.   .  ..  .|.... .....|   .|.  .   | |     . .  ||||  .      . .| |  . .  .  ||.|| .    .||.| 
rinivadlddyqrllsisetarleavnrn.vvkivpydrylvrltssqln.rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqll

NNLHEHDQEYPQYLPVEG--ATKYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEV
... .. ... .|.| ..    |.|.. |   .  ... .   .|....  .||.| | .   | .  .| .
edvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpky

subfamily_PTPRA_pd Subfamily PTPRA 280-530 6.8e-74 243.7 In-house 39-294 (330) alignment
Range on Protein: 280-530
Range on HMM: 39-294/330.0
NSVTSREIPAEeKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHE
|.. . .| |    . .| .| .|||. .|.  .  ||.| . .  |||||||| |..   |.. |||.| |...|.||||||. ...  ||||| .|.|
nalPagpiqat.lelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelke

HDQE-YPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVT------RNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGNaPVLVQCS
 ..|   || | ||.  ||.|||..  ...  |.   |. |.      |.||.  || .|  ||||  .|  .. .|.|| .|.. .|| .. |. | ||
rkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcs

NGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKY
 ||||.|||.....|.||.|.|...|||...||.|..||  | .. ||.|.|.....|
aGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley

subfamily_PTPN14_pd Subfamily PTPN14 280-532 1.1e-46 154.2 In-house 30-297 (300) alignment
Range on Protein: 280-532
Range on HMM: 30-297/300.0
NSVTSREIpAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADeESDYINAVFL--HVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNL
. .. ..    . |... |.| .|||| |..  . .|| |   . . ...||||  .   |  ..  .|..| ||..|..|||.|| . ..  |||| . 
eripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmltee

HEHDQEY-PQYLPVE----GATKYGHIRVSLLSKQEKGDVISTKLKVT--RNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQC--------
.|. .|   .|.| .       ..|. .|.   ... . || |.||.     |.  .| || .. |||. .||  .. |. |.|||. ...         
eedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveske

GNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLD
 . |||| ||.||||.|       .|. |.....||. .|..|.|  |   |..|.|| | |... |||.
skPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 283-537 1.6e-57 190.2 In-house 8-262 (284) alignment
Range on Protein: 283-537
Range on HMM: 8-262/284.0
TSREIPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNnlhehDQ
. . ... ...  . .||  |||. .|.| .  .| |..    | |||||| |.     .. .|||| ||. |..|||||. .|.. |||.|      ..
cklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kd

EYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTR---NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQ-ASQQQCGNAPVLVQCSNGVGRS
   || | ..  |... .|.. | .|  . .  ......   .|.  ..|  |   |||.  |. .  .. |.. |.  .... ..|...| || ||||.
kcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrt

GTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQ-KYLDSFSDY
|.. ..  ...|.| |. .||..... .| .|.  |..|.|| |.|  .  ..| ..|| 
gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdv

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 283-529 4.3e-31 102.6 In-house 20-267 (281) alignment
Range on Protein: 283-529
Range on HMM: 20-267/281.0
TSREIPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHK-EHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHD
   . |..  .| ..| | .|||...| .|.  || |.      . .||| | ...  . .  .| || | . |  |||||. . .  .|||| .. | .
lpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletn

QEY-PQYLPVEG--ATKYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASqqqcgNAPVLVQCSNGVGRS
.|   .|.| .   . .. .. ||      .  ...|.|... . .|. . |     |||  .|| .  .| .| ...|       .| ...|| |||||
rekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar.....stppvihcsagvgrs

GTFCAISSVIERLKTEQ-VIDVFQVIKRIRA-NRPGAVESLTQYVFCYQIIQK
||. |.   .. ...   . |. |.. ..|   |  .|..| ||.. ....  
gtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 284-400 4e-18 60.2 In-house 31-161 (350) alignment
Range on Protein: 284-400
Range on HMM: 31-161/350.0
SREIPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLH--------KEHADEESDYINAVFLHVR---MERN-A--FIATQHPLQHTIEDFWRMVTDYDIG
. | | ..  . |  .   |||...|.  .  || |.        |.|. . .||||| .|..    .| |    .|||| ||. |..||.....  .. 
dsespsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvk

TIVMLNNLHEHDQEY-PQYLPvEGATKYGHIR
 |..|... |.. |   .| . ||. .  ...
vilsltsdvelnlekcyrYWq.egsydditvk

subfamily_PTPN3_pd Subfamily PTPN3 285-532 6.7e-50 164.6 In-house 26-277 (280) alignment
Range on Protein: 285-532
Range on HMM: 26-277/280.0
REIPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEhadeESDYINAVFLHVRMER----NAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEH
|  |  . |.  ||.||.|||. ||.. .. ||.|...    |.||||| .. . ..     | .|||| ||..| .|||.|| . .. .|||| .| |.
rkkpglaisaarkpenlsknryrdilpydatrvklkes....etdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlver

DQ-EYPQYLPVEG-ATKYGHIRVSLLSKQEKGDVISTKLKVTRNK--KTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQqQCGNAPVLVQCSNGVG
 .    || | ..  ..||...| . ...|.  ..  .| .....  . ... .| ...|||...|. . ..|.....|.. . .  . ||.| || |.|
GrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr.sgkeePvvvhCsaGig

RSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVF-CYQIIQKYLD
|.| . ..   .  . ... . . ......|  |   |.. .|| | |  |.. | .
rtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 285-532 6.1e-37 122.0 In-house 24-278 (287) alignment
Range on Protein: 285-532
Range on HMM: 24-278/287.0
REIPAEEKSVgEKPQNLHKNRFSDIIALNSCRVMLHKEhADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVML-NNLHEHDQE
.  .|  |.  |.  . .|||..|.. ..  ||.| .| ..  |||||| ..    . .||||.| |.  |. ||||.| .    .....  .. |  ..
esstatfkaa.eelaavkknryadvlPiddtrvllsae.gelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlk

YPQYLPV-EGATKYGHIRVSLLSKQEKGDVIST-KLKVTR--NKKTHEVRHLHHVSWPDKCIPEV----ARSVLDLLDEVQASQQQCGNAPVLVQCSNGV
  .| |  |   . |   | ||... |    ..  |..     .... |. |. .||||| ..      .| |||  . ......  .  |..| .. |.
cykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGi

GRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLD
||||.. |.  ...||.    .|| .|. |.|  | . | .  |. . |. .  |  
GrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 285-444 2.2e-27 90.7 In-house 18-182 (297) alignment
Range on Protein: 285-444
Range on HMM: 18-182/297.0
REIPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHadEESDYINAVFLHVRMERN--AFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHD-
.|  .|. |.  ..  |.|||. ||.| .. || | .     |.||||| ..    | .   .| .| ||. |..|||..|.. |...|||. .| |   
deargesfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGr

-QEYPQYLP-VEGATKYGHIRVSLLSKQ--EKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEV
 . .| .   |..  | |.. |  ||.   |   || |.|..   ...  |||  ..||||. .|  
dkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsd

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 287-532 4.7e-61 201.3 In-house 31-278 (315) alignment
Range on Protein: 287-532
Range on HMM: 31-278/315.0
IPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQ-EYP
 .. .. |. ...| .|||. .|. |.| ||.|     . .|||||| ...   . .|.||.| ||. ...|||||| .... ||||.....| |. .  
PdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcr

QYLPV--EGATKYGHIRVSLLSKQEKGDVISTKLkVTR-NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASqQQCGNAPVLVQCSNGVGRSGTFC
|| |     ....| |.|.||| .  .| .  || |||  .... |   .   |||| ... . |.| |. ||.|. ..  . ..|| || ||||.| ..
qywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvi

AISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLD
.| .|....| ....|||...| .||.||  | .  .| | |......| 
sidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll

subfamily_ptpA1_pd Subfamily ptpA1 287-491 1.8e-30 101.0 In-house 34-256 (418) alignment
Range on Protein: 287-491
Range on HMM: 34-256/418.0
IPAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERnAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHE-----HD
.   | | |.| .|  |||...|. .|  || |.| .  | |||||| ..     .  ||.|| ||  || |||||| .     ||||.   |      |
vgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcd

QEYPQYLPVEGATK-------YGHIRVSLLS--KQEKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQC-----GNAPV
. .|. .  |  .        .|   | |.   .. . ..|. ....| . .|... . ..  |||. ||. .. . .||  .   |.|       | |.
rywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpi

LVQCSNGVGRSGTFCAISSVIERL
.|.|| ||||.||||.   ....|
ivhcsagvgrtgtfctavimmkkl

subfamily_PTPN9_pd Subfamily PTPN9 288-530 8.8e-58 190.7 In-house 30-289 (297) alignment
Range on Protein: 288-530
Range on HMM: 30-289/297.0
PAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQ-EYPQ
.. .  . ... ||.|||..|.. ... ||.| |.. ||.|||||| |.    ...|||||| ||..|..|||||| . .. .|||   . |. .    |
veGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgq

YLP--VEGATKYGHIRVSLLSKQEKGDVISTKLKVT--RNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQ------------QCGNAPVLVQ
| |   | ....|...|| .. .|. |   ..|...  ..... .| |   .||||  .|. | |.||.|..|.  |             .. . |..| 
yWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvh

CSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKY
|| |.||.|||...   ..||......||....|..|. |  ..    ||.|||. .  |
csaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley

subfamily_PTPRN_pd Subfamily PTPRN 288-528 3.3e-46 152.3 In-house 44-289 (297) alignment
Range on Protein: 288-528
Range on HMM: 44-289/297.0
PAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERN-AFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQE-YP
  . |.|.....|..||| ..... .  || |..| ..|.|||||| ..  .  |. |.|||| || .|. |||.|| .  .  ||.| .|.|.. .   
epstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqck

QYLPVEGATKYGHIRVSLLSKQEKGD---VISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQcGNAPVLVQCSNGVGRSGTFC
.| | ||.  |.   | |.|.    |   | |  ||  ....|  |  .|..|||.. .|  |.|.|..   |. | .    .|..| ||.|.||.|...
rywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyi

AISSVIERL-KTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQ
.|  |..|| |  . ||.   .. .| .||| |..  |. |... . 
lidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 288-527 1.3e-44 147.2 In-house 33-232 (392) alignment
Range on Protein: 288-527
Range on HMM: 33-232/392.0
PAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDqeypqy
.. ...|..|. ||.|||. .|. ..| ||.|       .|||.|| ...     .|.||.| |   ...|||||| . .. ||.|...|.| |      
diypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd......

lpvegatkyghirvsllskqekgdvistklkvtRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGnAPVLVQCSNGVGRSGTFCAISSV
                                 . .... |   | . |||| .|. . |.| .. ||.|   |    |....|| ||||.|   .| ||
.................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyt.hpliihcsagvgrtgvvisidsv

IERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQII
. . |. ...|||...  || .||  |..  || | |  .
vahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 288-384 4.2e-09 30.2 In-house 36-148 (349) alignment
Range on Protein: 288-384
Range on HMM: 36-148/349.0
PAEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKE--------HADEE------SDYINAVFLHV-RME-RNAFIATQHPLQHTIEDFWRMVTDYDIGTI
....  . |  .   |||..||.  .  ||.|.|         ..  |       ||||| .|.. |..  . .|||| ||  |..||.....   .  .
eiddvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklv

VMLNNLHEHDQEY
. ||. .| . | 
lsLnddkelslek

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 289-534 4.5e-73 241.1 In-house 35-286 (305) alignment
Range on Protein: 289-534
Range on HMM: 35-286/305.0
AEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEY-PQY
 |   ||.| .| .|||...|. |.  |..| ... ...|||||| ...   .....|..| ||..|..||||.. .. . ||||| .| | ...   ||
eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqY

LPVEGAT--KYGHIRVSLLSKQEKGDVISTKLKVTR---NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGNAPVLVQCSNGVGRSGTFC
 | . .   ..|.. | | |...  | |  |||..    .|... | ...  .|||. .|. | |.|.|...|| .|..  . |.|| ||.||||.|.|.
WpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfi

AISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSF
|..  .||||.|.|.|||.|.|..| .|...|..| ||||......... ..
avdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg

0045098 (Phosphotyrosine protein) phosphatases II 289-531 1.4e-66 220.0 In-house 22-272 (278) alignment
Range on Protein: 289-531
Range on HMM: 22-272/278.0
AEEKSVGEKPQNLHKNRFSDIIALNSCRVMlhkehadeesDYINAVFLHVRmeRNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEH-DQEYPQY
  | ... .. ||.|||..||......||           ||||| ....   ...|||||.||..|..|||||. ...| .||||..|.|   . ..||
pseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

LPVEGATKYGHIRVSLLSKQEKGDVISTKLKVT------RNKKTHEVRHLHHVSWPDKCIPEVA--RSVLDLLDEVQASQQ------------QCGNAPV
 | .|   ||...| ||| .. .|.. ..|.||       . ....|.||| ..||| ..|.    .|.|.||..... ..            . .. ||
wpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

LVQCSNGVGRSGTFCAISSVIERLktEQVIDVFQVIKRIRANRPG-AVESLTQYVFCYQIIQKYL
|| || ||||.||..|.  ..|.|  |...|.....| .|  ||| ||..| ||.|.|. ....|
lVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 289-539 1e-55 183.6 In-house 29-301 (301) alignment
Range on Protein: 289-539
Range on HMM: 29-301/301.0
AEEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHA--DEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEH-DQEYP
 .. .|| . .| . ||| .|  ..  |..|.....    . .|||| ...   |...|||.| |...|. ||||.. ..   .|||. ||.|   ..  
dksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskce

QYLPVEG--ATKYGHIRVSLLSKQEKG-----------------DVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGNAP
|| |      ...|.. | | ..|                      |  |.||...|....|  |. ..||.  .    | ||  .|.|   ||. | .|
qywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggp

VLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSFSDYAN
|.| ||..|.|||..|..|  .|  | | |.|||||.|..| ..||||  | ||.. |..|..||   | |||
vvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 290-532 7.6e-53 174.2 In-house 10-265 (270) alignment
Range on Protein: 290-532
Range on HMM: 10-265/270.0
EEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLH-VRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEY-PQY
.|... |  .. . ||. ||.     ||.|.... |... |||| ... .  |....||.. ||. |...||||. .    .|||. .|.|. ..   .|
sesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

LPVEG----ATKYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVAR------SVLDLLDEVQASQQQCGNA-PVLVQCSNGVG
 | |     ....|.|.|  ||.. .   | |.|..... ..... | ....|||. .|. .       ..| .| .|..|...  .| |.|| ||.|||
WpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvg

RSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLD
|.||. |.  ... |.... .|| ..|...| .|.  |.   || | |. ...| .
RtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae

subfamily_PTPN1_pd Subfamily PTPN1 290-527 1e-43 144.1 In-house 22-267 (290) alignment
Range on Protein: 290-527
Range on HMM: 22-267/290.0
EEKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHAdeesDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQE-YPQYL
 . .. ..|.|  .||. |.   . .|..|....     ||||| ....   .  .| || || .|.. ||.|| . .  ..||||.. |..|    || 
fptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

PVEGA---TKYG--HIRVSLLSKQEKGDVISTKLKVTR--NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQC-GNAPVLVQCSNGVGRSGT
| .      ..   ...| |.|...|   .  .|...    ..|.|. | |...|||  .||   . |..| .|. |        |... || |.|||||
PqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

FCAISSVIERLKTE---QVIDVFQVIKRIRANRPGAVESLTQYVFCYQII
|| . ... ... .   . .|. .|.  .|  | | .    |  | |. |
fclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 291-533 1.8e-65 216.0 In-house 42-286 (297) alignment
Range on Protein: 291-533
Range on HMM: 42-286/297.0
EKSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFlhVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEYPQYLPV
.. | ||  |..|.|...|.  .| ||.|.    | .|||.|| |  |.  .. .|.|| | . |..|||.|| |... ||||||...| |..  .| . 
pqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasf..vkgnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsd

EGATKYGHIRVSLLSKQEKGDVISTKLKVTRNK--KTHEVRHLHHVSWPDKCIPE--VARSVLDLLDEVQASQQQCGNAPVLVQCSNGVGRSGTFCAISS
.| |..|.. | ||| .|.   |  .|.||..|  ... |.  ..|.|||| ...   |.|.|.|..||. . .|  ..|.|| |..|||| | ...| |
kgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltids

VIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDS
|. . | |. .|.|...|..| .||  |    || | |... ..| |
vvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 292-539 1e-134 442.4 In-house 1-250 (250) alignment
Range on Protein: 292-539
Range on HMM: 1-250/250.0
KSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEYPQYLPVE
|||..||||..|||..|||||.|.||.|.||..|.|||||||.|||...||.||||||.|||.|||||||||.....||||||.||.|....|.||.|||
ksvakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPve

GATKYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHE--VRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGNAPVLVQCSNGVGRSGTFCAISSVIE
.|.|||...||||||.|..|....|||....||..|  ||.||.|.||||..||||..||.||..|||||||.|||||.||||.||||||.|.||..|.|
kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

RLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSFSDYAN
|||.|.|.|||.|||..|..||.|||||.||||.|.||.|.|||..|||.
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar

0040439 (Phosphotyrosine protein) phosphatases II 292-531 3.9e-71 234.9 In-house 3-246 (249) alignment
Range on Protein: 292-531
Range on HMM: 3-246/249.0
KSVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEH-DQEYPQYLPV
.||...| |..|||..||......|| |.     . |||||| ....    ..|||||.||..|.||||||. ...|..||||..| |.  . . || | 
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

EGATKYGHIRVSLLSKQEKGDVISTKLKVT--RNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQC-GNAPVLVQCSNGVGRSGTFCAISSV
.| ..||...| ||| ..|.|.. ..|..|   ......|.|.....|||  .|.   ..||....|.  ....  . |||| ||.||||.|||.|.  .
ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

IERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
.|.|..|. .|.....| .|  |||||... ||.|.|......|
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 292-349 7.3e-08 26.5 In-house 40-94 (95) alignment
Range on Protein: 292-349
Range on HMM: 40-94/95.0
KSVGEKPQNLHKNRFSDIIALNSCRVMLHKEhadEESDYINAVFLHVRMERNAFIATQ
 .||    |. |||| .|.  .. ||.|       .||||||.|.     .|..||.|
ytvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaq

0042113 (Phosphotyrosine protein) phosphatases II 293-531 4.7e-70 231.1 In-house 2-243 (245) alignment
Range on Protein: 293-531
Range on HMM: 2-243/245.0
SVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQE-YPQYLPVE
||...| | .|||.|||......|| |  .  |. |||||| . ..    . |||||.||..|.||||||. ...| |||||....|.... ..|| | .
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GATKYGHIRVSLLSKQEKGDVISTKLKVT--RNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGNAPVLVQCSNGVGRSGTFCAISSVIE
. ..||...| ||| . ..|.. ..|.||  ......||.|.|...||| ..|.  ...||.|..|.  .....| |||| || ||||.|||.|.  ..|
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

RLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
.|..|. .......|..|  |||||... ||.|.|......|
qlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_PTPRK_pd Subfamily PTPRK 293-527 8.1e-68 223.6 In-house 36-273 (314) alignment
Range on Protein: 293-527
Range on HMM: 36-273/314.0
SVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHD-QEYPQYLPVE
 .  | .| .|||. ||.| . .||.|.  . | .|||||| ..      .|||.||.|||.|..||||.| |..  .||||..| |.   .  .| | .
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

GATkYGHIRVSLLSKQEKGDVISTKLKVTR----NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQcGNAPVLVQCSNGVGRSGTFCAISSV
. . ||.|.| |.. . . ....  ..|..     ....|||......|||  .|  |...|.|. .|..||.. .. ...| ||.| ||.|||.||..|
tev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidiv

IERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQII
.. ...|.|.|||...| .|....  ||   ||.|.|..|
ldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 293-529 5.6e-44 145.3 In-house 41-277 (439) alignment
Range on Protein: 293-529
Range on HMM: 41-277/439.0
SVGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQeypqYLPVEG
|.  .  .  |||. |. |..  ||.|..      | |||| ...   . . .|||| | ..| .||||.| .    ||||| || |  .    | | ..
slaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk....ywpsda

ATKYGHIRVSLLSKQEKGDVISTKLKVTR----NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGNAPVLVQCSNGVGRSGTFCAISSVI
 . || | |    . |  . .   .||      ..| . | ..|...|||| .|  |  |||.|  .......    ||.|.|| ||||.||  |.   .
evcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdial

ERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQK
|.||.|. .|.  ..| .| .|   |..| |||| |. . .
eqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle

0037934 (Phosphotyrosine protein) phosphatases II 294-531 2.1e-63 209.4 In-house 4-242 (243) alignment
Range on Protein: 294-531
Range on HMM: 4-242/243.0
VGEKPQNLHKNRFSDIIALNSCRVMLhkehadEESDYINAVFLHVRmeRNaFIATQHPLQHTIED----FWRMVTDYDIGTIVMLNNLHEH-DQEYPQYL
.. .|.||.|||.|||....  || |      | |||||| .  |   .. .||||.||..|.||    ||||. ...|..||||..| |.  . ..|| 
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PveGATKYGHIRVSLLSKQEKGDVISTKLKVTR---NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQ-------CGNAPVLVQCSNGVGRS
|  | . ||...| ||| ....|.. ..|....   .. |..|.|.|...||| ..|.   ..||.||||.. ...        .. |||| || ||||.
p..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GTFCAISSVIERLkteQvIDVFQVIKRIRANRPG-AVESLTQYVFCYQIIQKYL
||..|.  ....|   . .|.....|..|. ||| ||... ||.|.|......|
Gtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 294-531 1.5e-62 206.3 In-house 37-276 (515) alignment
Range on Protein: 294-531
Range on HMM: 37-276/515.0
VGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQE-YPQYLPV--
| ..  | .|||. .|. ..| || |   . . .|||.|| ...     .|.||.| |.. ...||||.| .... ||.|...|.| |.    .| |   
vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp

EGATKYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGnAPVLVQCSNGVGRSGTFCAISSVIER
  . |.|.|.|.|.| .  .. |  ||.|....... |   |   |||| .|. ..|.| |. ||.|...|    |... || |||| | ...| ||. .
gdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvah

LKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
 || ...|||.... ||..||  |    || | |.... .|
akttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 294-527 2e-62 205.9 In-house 43-275 (315) alignment
Range on Protein: 294-527
Range on HMM: 43-275/315.0
VGEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEYPQ-YLPVEg
|  | .| .|||. .||| .  || |     |..|||.|| |.     .. .||.| |.  ...||||.| ..|||.||||.|| | ...  . | | . 
vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.

ATKYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGnAPVLVQCSNGVGRSGTFCAISSVIERLK
   ||.| |.. |.. . ..    | |. ... .||  ||. ||||  .|. . ....|   |.  ...   ....| ||.||||.|||.....|.....
kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqae

TEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQII
.|..|||...|...|.|| ..|... || | |...
aenaidvynfitgvrqnrikmvqvaeqyqfiydal

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 294-531 1.9e-36 120.6 In-house 37-271 (288) alignment
Range on Protein: 294-531
Range on HMM: 37-271/288.0
VGEKPQNLHKNRFSDIIALNSCRVMLHkehaDEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQE-YPQYLPVEG
. .  .|  ..|. ..   . .|| |.    |.   ||.|  .     .. .| .| ||. ||| .|.|. . |.  ||||..| |. .|   .|.|.. 
idsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl

ATKYGHIRVSLLSKQEKGDV----ISTKLKVTRNKKTHE-VRHLHHVSWPDKCIPEVARSVLDLLDEVqasqqQCGNAPVLVQCSNGVGRSGTFCAISSV
  |    |.    |... |.      . |..... ...  |..||   |.|...||   | | ||. .     .  . |..|..|.||||.||.  |  .
GekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililia

IERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
.| |. .  . . ..... |..|  |...  ||.. .... ..|
leslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel

subfamily_egg_pd Subfamily egg 295-530 1.3e-25 84.7 In-house 35-269 (307) alignment
Range on Protein: 295-530
Range on HMM: 35-269/307.0
GEKPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQeYPQYLPV---E
  .  ||.| |   .   .|.|| |. ..     |.| |  .. .   | || .| ||. | .||||||   ..  ||||.   | ..  . | |    .
aasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeser.ceyywpkaesd

GATK-YGHIRVSLLSKQEKGDVI--STKLKVTRNKktHEVRHLHHVSWPDKCIPEVArSVLDLLDEVQASqqqcgNAPVLVQCSNGVGRSGTFCAISSVI
 .    | .|.  |  ..| | .   ||||.   .  .| |.| |  .  .   .|  | | .|  ..         ||.||. .|| ...|. ||   .
slvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqgdvnnssdvy.splrvlrklrnl.....skpvvvqdilGvskaatlvaieial

ERLKTEQV--IDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKY
  |    .    | . .. .| .|. .|||  .|.| |...  .
lsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlff

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 295-374 3e-11 37.4 In-house 32-116 (347) alignment
Range on Protein: 295-374
Range on HMM: 32-116/347.0
GEKPQNLHKNRFSDIIALNSCRVMLHKEH-----ADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVML
 |  ..| |||  |    .. ||.|  |.     ||.   ||||  ..    .. .| ||.|| .|. |||.||.   .  .| .
vewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 296-531 3e-32 106.6 In-house 44-287 (305) alignment
Range on Protein: 296-531
Range on HMM: 44-287/305.0
EKPQNLHKNRFSDIIALNSCRVMLHKEHAdeeSDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHD-QEYPQYLPVEGAT
 . |. .|||. |.  |.  || |.        .|| | ..    . . || || ||..|  ||| |  .  . .| || || |.  .   .|.. .   
keaqeagknrykdvgcldnnrvklegpwp...heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkd

------KYGHIRVSL-------LSKQEKGDVISTKLKVTR-NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQqqcgnAPVLVQCSNGVGRSGT
      |  .| | .       . |. | .|  |.| .    .|.. | | | . |||. .|    ..|.|| . ..|.      |. | || |.||.|.
vlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk.....gpivvhcsagigrtgs

FCAISSVIERLKTEQVID-VFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
   .  ....| . |.|.   .....|| .|  .... .||.| .|.| .|.
vvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 297-532 7.7e-57 187.5 In-house 25-269 (274) alignment
Range on Protein: 297-532
Range on HMM: 25-269/274.0
KPQNLHKNRFSDIIALNSCRVMLHKEHADEE-SDYINAVFLH-VRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQ-EYPQYLPVEGA
 . . .|||. .|.  .  ||.|..|....| |.|||| ...  . | .|..||| ||..|..|||||.   ..  |||| .|.|...    .| | .  
vfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaed

T----KYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGN--APVLVQCSNGVGRSGTFCAISSV
.    .||.. .   .. |. |   .|| .   .....| |  . .|||.  |. |...|||..||. |...  .  |||.| || |.|| | | |||  
yeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisia

IERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLD
. .|. |.|.||....  .| .| | |..  || . .... .|| 
vrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 297-524 5.1e-40 132.1 In-house 5-234 (239) alignment
Range on Protein: 297-524
Range on HMM: 5-234/239.0
KPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHV-RMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHE-HDQEYPQYLPvEGAT
|  |  |||...|.. .  ||.| |   |  |||||| .|.      .|.||||  .. .  |||||. .     ||||  | | | ..  || | . ..
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dsts

KYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHE--VRHLHHVSWPDKCIPEVARSVLDLLDEVQAsQQQCGNAPVLVQCSNGVGRSGTFCAISSVIERLK
||  .||.|   .   | |   . ...  .| |  | . |   |||| .|. | .|| |  ..   .   |  | ...|| ||||.|.|  | ... . |
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqak

TEQVIDVFQVIKRIRANRPGAVESLTQYVFCY
 .. .|.|. .| || .||  |..  |||| .
kqktvdifnyvkairedrphmvqtseqyvfih

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 297-524 5.5e-40 132.0 In-house 4-233 (239) alignment
Range on Protein: 297-524
Range on HMM: 4-233/239.0
KPQNLHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLHV-RMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHE-HDQEYPQYLPvEGAT
|  |  |||...|.. .  ||.| |   |  |||||| .|.      .|.||||  .. .  |||||. .     ||||  | | | ..  || | . ..
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dsts

KYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHE--VRHLHHVSWPDKCIPEVARSVLDLLDEVQAsQQQCGNAPVLVQCSNGVGRSGTFCAISSVIERLK
||  .||.|   .   | |   . ...  .| |  | . |   |||| .|. | .|| |  ..   .   |  | ...|| ||||.|.|  | ... . |
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqak

TEQVIDVFQVIKRIRANRPGAVESLTQYVFCY
 .. .|.|. .| || .||  |..  |||| .
kqktvdifnyvkairedrphmvqtseqyvfih

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 297-531 5.2e-37 122.5 In-house 38-277 (307) alignment
Range on Protein: 297-531
Range on HMM: 38-277/307.0
KPQNLHKNRFSDIIALNSCRVMLHKEHAdeESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQ-EYPQYLPVEGATK
   | .|||..|. . . .|.... . .   |||| | .| . .. . ||..| ||. |. .|| |. . .. ...|| .. |  .    || |.|   |
fsantdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqk

--YG----HIRVSLLSKQE---KGDVI-STKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQqqcgnAPVLVQCSNGVGRSGTFCAIS
  .|     | |. |  ..     |.|  |.|||   .|.  ..||    |||. .|..  . ..||. |.  .      ||.| || |||||||  |||
lvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt.....npvvvhcsaGvGrsGtivais

SVIERL-KTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
 | ... . .   |. .... .|..|. |...  ||.. .... .|.
lvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 297-530 1.1e-24 81.6 In-house 44-278 (303) alignment
Range on Protein: 297-530
Range on HMM: 44-278/303.0
KPQNLHKNRFSDIIALNSCRVMLHkehadeESDYINAVFLHVRMERNAfIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEYPQYL-PVEG-AT
  .|..|||| |.| |.  .| |       .| || | .|..  ...| | || ||.||  |||.|. .  .  ...|    |.|.   ... | .    
fvknmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdfl

K--YGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVRHLHHV-SWPDKCIPEV-ARSVLDLLDEVQASQQQC-GNAPVLVQCSNGVGRSGTFCAISSVIE
|     |||  . . | ||  . |.    | . .   |.||  .|| . ||   .  ..  . ..|.  ..   . | .     |.||.|||. . .   
kfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahl

RLKTEQV-IDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKY
 |..||  .|. .... .|  |  ||. |.|. . | .. ..
slhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 299-527 7.4e-39 128.4 In-house 2-235 (237) alignment
Range on Protein: 299-527
Range on HMM: 2-235/237.0
QNLHKNRFSDIIALNSCRVMLHKEHADeeSDYINAVFLHV-RMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQE-YPQYLPV-EGATK
.|  |||...|.| . .||.|.   ..  |||||| .|.      . .||.| ||. . .|||.|| .     ||||  | | ...   .| |  .  . 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVRHLH---HVSWPDKCIPEVARSVLDLLDEVQ-ASQQQCGNAPVLVQCSNGVGRSGTFCAISSVIERL
|| . |||  |.|  |     | .... . .||| .|     ||||. .|. . ..| .  ..   |.     .| .. || ||||.| |  | ... . 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQII
| ..|.|... .. |  .||  ...  |||| .| |
kekkvvdiynyvysieedrpyiiqtkdqyvfihqti

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 299-531 3.1e-26 86.5 In-house 50-285 (302) alignment
Range on Protein: 299-531
Range on HMM: 50-285/302.0
QNLHKNRFSDIIALNSCRVMLHKEhadeESDYINAVFLHVRMERNAFIATQHPLQHTI---EDFWRMVTDYDIGTIVMLNNLHEHDQEYPQYLP--VEGA
.||.||.  |. .|.| .| |..|    . .|.||  ..|   ..  | .| | . .    |.||||| .  | ..|.|    | ..   ...|   .  
knlkknqsedvpildsnlvkleae....pdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdy

TKYGHIRVSLLSkQEKGDV--ISTKLKVTR----NKKTHEVRhlHHVSWPDKCIPEVARSVLDLLDEVqASQQQCGNAPVLVQCSNGVGRSGTFCAISSV
..||...|      || .       . |      |    .|   ..  |..| .|.   ..     .|   ... .......   ||.|| |.| .   .
keygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvy..vltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlava

IERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
.|.|....   . ...| ||..|| ||.||.|||. | ..  |.
veklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 299-383 3e-06 20.9 In-house 33-116 (332) alignment
Range on Protein: 299-383
Range on HMM: 33-116/332.0
QNLHKNRFSDIIALNSCRVMLHKEhaDEESDYINAVFLHVRMERNAFIATQHPLQ-HTIEDFWRMVTDYDIGTIVMLNNLHEHDQE
.|.  ||   . ...  || |  .  | . |. || ..    ...|.| .| |.. ||   |||||..     |... .. |... 
nnmdmnriphlycfdhsrvelapq..dgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkr

Y_phosphatase Protein-tyrosine phosphatase 300-528 5.4e-73 240.6 Pfam-A 1-234 (235) alignment
Range on Protein: 300-528
Range on HMM: 1-234/235.0
NLHKNRFSDIIALNSCRVMLhkEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEH-DQEYPQYLP--VEGATKY
|..|||..||.. .. || |  .. ...|||||| ...   | ..|||||.||..|||||||||..... .||||..| |  .....|| |   |. ..|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GHIRVSLL--SKQEKGDVISTKLKVTRNKKT---HEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQqQCGNAPVLVQCSNGVGRSGTFCAISSVIERL
|.|.| |   .|... ... .||... .|.    .||..||. .|||...|| ..|.|||...|. |. .  ..||.|.||.||||.|||.|.. ..|.|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQ
..|. .||.|..|..|..|||.|.||.||.|.|..|.
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 300-528 5.4e-73 240.6 In-house 1-234 (235) alignment
Range on Protein: 300-528
Range on HMM: 1-234/235.0
NLHKNRFSDIIALNSCRVMLhkEHADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEH-DQEYPQYLP--VEGATKY
|..|||..||.. .. || |  .. ...|||||| ...   | ..|||||.||..|||||||||..... .||||..| |  .....|| |   |. ..|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GHIRVSLL--SKQEKGDVISTKLKVTRNKKT---HEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQqQCGNAPVLVQCSNGVGRSGTFCAISSVIERL
|.|.| |   .|... ... .||... .|.    .||..||. .|||...|| ..|.|||...|. |. .  ..||.|.||.||||.|||.|.. ..|.|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQ
..|. .||.|..|..|..|||.|.||.||.|.|..|.
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail

0041856 (Phosphotyrosine protein) phosphatases II 300-529 2.7e-42 139.8 In-house 1-169 (182) alignment
Range on Protein: 300-529
Range on HMM: 1-169/182.0
NLHKNRFSDIIALNSCRvmlhkehadeESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNnlhehdqeYPQYLPvegatkyghi
||.|||.|||.  .  |           .||||| ..   .  . |||||.||..|..||.||. ...|.|||.|.         ..| |          
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywp..........

rvsllskqekgdvistklkvtrNKKTHEVRHLHHVSWPDKCIPEvARSVLDLLDEVQAsqqqcGNAPVLVQCSNGVGRSGTFCAISSVIERlkteQvIDV
                      .. .... ......||| ..|.  ...||...||..      . |||| || ||||.||..|.  ....    . ...
......................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsl

FQVIKRIRANRPGAVESLTQYVFCYQIIQK
....| .|  |||.|... ||.|.....  
eeavklvrsrRpgmvitpnqyfflqlalle

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 300-531 8.5e-31 101.7 In-house 55-289 (305) alignment
Range on Protein: 300-531
Range on HMM: 55-289/305.0
NLHKNRFSDIIALNSCRVMLHKEHadeESDYINAVFLHVRME-RNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHD-QEYPQYLPVEGATK--
.  |||..|. . .   | |.|      |||| | .. . |   . ||..| ||..||..|| || .  .  |||| .  |       || |.    |  
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

-YGHIRVSLLSKQ----EKGDVISTKLKVTR-NKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQqqcgnAPVLVQCSNGVGRSGTFCAISSVIE
  . | |  .|         ..  | |..|   ...  ||||.   |||. .| .  . |.||  .. |.      |..|.|| |.||.||  ||  ..|
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk.....vpivvhcsagigrtgtivaieyile

RLKTE-QVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
..  . ..  . ...| .| .|  ....  ||.| .... .|.
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 300-531 7.8e-30 98.8 In-house 35-270 (285) alignment
Range on Protein: 300-531
Range on HMM: 35-270/285.0
NLHKNRFSDIIALNSCRVMLhKEHadeESDYINAVFLHVR-MERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEY-PQYLPV--EGATK
|   ||..|. ...  ||.| |.|   . ||| | ....   .....|.|| ||  |. |||.|. .  |  ..||  | |   |    | |       |
npdlnryadvrcieetrvvl.knh...drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

YGHIRVSLLSKQEK--GDVISTKLKVTR-NKKTHEVRHLHHV---SWPDKCIPEVARSVLDLLDEVQASQqqCGNAPVLVQCSNGVGRSGTFCAISSVIE
.|.  ..|   .|.     |   | |.  .  . |  .. ||    |||.  || || ...|   |.  .    . |. |.|| ||||. ||  |     
fgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvn..pkekpicvhcsagvgrtatfvgidyati

RLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
|.  .  |....... .|| |  ||.|  |..| | .. .|.
rimenpniemldivremramrfqavqshmqflflyvvlmeyf

subfamily_CG42327_pd Subfamily CG42327 301-458 7e-20 65.9 In-house 29-193 (319) alignment
Range on Protein: 301-458
Range on HMM: 29-193/319.0
LHKNRFSDIIALNSCRVMLHKEHADEESDYINAVFLH-VRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHD-QEYPQYLPV----EGAT
  |.|. ... |   ||.|..   |... |..| ..   .  .| .||.| .|. .  ||||.| .    .|| | .|.|   .  ..|||     ..  
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

KYGHIRVSLLSKQEKGD-VISTK-LKVTRNKKTHEVRHLHHvSWPDKCIPEVARSVLDLLDEVQAS
 ||.|.|.|  .. |   .|||  ||   .... |. |  .  |..  .|   .... .| ||..|
lyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 304-535 2e-21 71.0 In-house 47-280 (312) alignment
Range on Protein: 304-535
Range on HMM: 47-280/312.0
NRFSDIIALNSCRVMLhkehADEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEY-PQYLP-VEGATKYGHIRV
||. .|   .  |  |    | .|  || | |...    . |..|| ||. |.  ||...      .|..|  . |   |   .|.  . |  .    ||
nrypniqcwdrgrftl....agdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

SL-------LSKQEKGDVISTKLKVTRNKKT--HEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQqcgnaPVLVQCSNGVGRSGTFCAISSVIERLK
         .  . |  .    |||  .       . |    ||||. .|.   . | ||  |.  ..     ||. .|| ||||.||.. | |.|  |.
yteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmiaalr

TEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSFS
  .  .| ..   .| .|  .|. . |||.. ... ..| | .
hprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskg

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 312-527 8.1e-22 72.7 In-house 30-255 (290) alignment
Range on Protein: 312-527
Range on HMM: 30-255/290.0
LNSCRVMLHKEHADEESDYINAVFLHVRmERNAFIATQHPLQHT-------IEDFWRMVTDYDIGTIVMLNNLHEHDQEYP-----QYLP--VEGATKYG
..  ||.|.       .||| | .. .  .  ..|.|| |....       ||.|| |. .  .  .||| . .|....       .| |  |..  |..
veatrvvLkgygkrfnddyiHAnrvtcp.nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfk

HIRVSLLSKQEKGDVISTKLKVTRN-KKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQasqqqCGNAPVLVQCSNGVGRSGTFCAISSVIERLK-TEQ
 . |.  || .. ||.  .| |. . .. . | |   ..| .  ..|  ...|.|.. |.     . ..||.| | .|. || .. ||      .  |..
gltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiilgyQkiaetsg

VIDVFQVIKRIRANRPGAVESLTQYVFCYQII
 . . .|.| .| .|  |. | ... |    |
svkledvlkalrkqralaitsalelafvdagi

0044763 (Phosphotyrosine protein) phosphatases II 314-530 6.7e-28 92.9 In-house 4-170 (178) alignment
Range on Protein: 314-530
Range on HMM: 4-170/178.0
SCRVMLHKEHADEESDYINAVFLHvrmeRNaFIATQHPLqhtiEDFWRMVTDYDIGTIVMLNNLHEHD-QEYPQYLPVEGAtkyghirvsllskqekgdv
 .|| |..    | ||||||..       . ......|     .|..... ...|..||.|..  |.  .....| | |                     
rtrvllsnleglersdyinaseil....pg.lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...................

istklkvtrnkkthevRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGnAPVLVQCSNGVGRSGTFCAISSVIERlkteQViDVFQVIKRIRANRPg
                 . .|. .|| . |.. . .|.... ... ....|  |||| || |||||||..|.  ....    .. .....|...|. || 
................iqylhipipDhgvpdllehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.

AVESLTQYVFCYQIIQKY
.|..  |. ..|.. ...
ivpnpgqlrqLyefelrl

0046846 (Phosphotyrosine protein) phosphatases II 321-532 8.5e-39 128.4 In-house 5-174 (176) alignment
Range on Protein: 321-532
Range on HMM: 5-174/176.0
KEHADEESDYINAVFLHVRMernaFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEY-PQYLPVegATKYGHirvsllskqekgdvistklkv
. . |. .||||| ..   .    .||||.|| .|..||..|. ...|...|.|....|...   |.| |.   .|.|.                     
llgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi.....................

trnkkthevrHLHHVSWPDKCIPEVaRSVLDLLDEVQASQQQcgNAPVLVQCSNGVGRSGTFCAISsvieRLKTEQVIDVFQVIKRIRANRP-GAVESLT
          . .|. ||| ..|.  . .|.||....  ...  . |||| || |.||.||..|.      |..|. ..|.......|. || |||..  
..........qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpe

QYVFCYQIIQKYLD
|| |.|. ....|.
Qyrflyefellllk

0043147 (Phosphotyrosine protein) phosphatases II 325-525 5.3e-41 135.5 In-house 2-155 (172) alignment
Range on Protein: 325-525
Range on HMM: 2-155/172.0
DEESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLhehdqeypqylpvegatkyghirvsllskqekgdvistklKVTRNKK
|| |||||| .|..    . ||||| ||..|..|||||. ...|..||.|..|                                         ... . 
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel........................................lydpell

THEVRHLHHVSWPDKCIPeVARSVLDLLDEVQASQQQCGNAPVLVQCSNGVGRSGTFCAISSVIerlkteQVIDVFQVIKRIRANRPGAVESLTQYVFCY
.... ......||| . |  .. .|..|. ..  .... . |||| || ||||.||..|.  ..      . ........ .|. |||||..  || |.|
erlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfly

Q
.
y

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 327-437 2e-11 38.3 In-house 12-122 (130) alignment
Range on Protein: 327-437
Range on HMM: 12-122/130.0
ESDYINAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEYPQYLPVEGATKygHIRVSLLSKQEKGDVISTKLKVTRNKKT-
. .|||| |. .    . .. |||||  |  |||.|. .  .  .|.|  . | |. .|.  |.|   .  .| |.|  ..|   . ...|.. .. .  
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeedeywpdsePlewyee..diivtltdrdefknikasnleiesdlnes

HEVRHLHHVS-WP
|.   . ..| ||
hqaltmfqisnwp

0051429 (Phosphotyrosine protein) phosphatases II 328-534 2.2e-46 154.0 In-house 4-228 (272) alignment
Range on Protein: 328-534
Range on HMM: 4-228/272.0
SDYINAVFLHVRME---RNAFIATQHPLQHTIEDFWRMvTDYDIGTIVMLNNLHEHDQEY-PQYLP------------VEGATKYGHIRVSLLSKQEKGD
|.|||| ..        .........||..|..||||.  ...| |||.| ...|....  ..|.|            ..    ||..|| |||.. . |
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

VISTKLKVT---RNKKTHEVRHLHHVSWPDKCIPEVArsVLDLLDEVQAsqqqcgNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVID--------VF
.| ..| .|    .....||.|||. .||| ..|. |  .|.||.....      . |||| || |..|.||..|.  .....  |...|        ..
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

QVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSF
......|| |||||.. .||.|.|......|.|.
eaveelraqrpgavqteeqylflyeallellrsl

0036282 (Phosphotyrosine protein) phosphatases II 328-525 5.4e-42 138.8 In-house 2-164 (174) alignment
Range on Protein: 328-525
Range on HMM: 2-164/174.0
SDYINAVFLHVRMERNAFIATQHPLQhtiedFWRMVTDYDIGTIVMLNNLHEHD-QEYPQYLPVegatkyghirvsllskqekgdvistklkvTRNKKTH
|||||| .|.. .  . .||.|.||.     ||.|. ...| |.|||....| .    ..| |                              .|.  ..
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.............................lredler

EVRHLHHVSWPDKCIPEVARsVLDLLDEVQASQQQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKtEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQ
.. ..... ||| . |...  .|.....|.  ...... |||| || ||||.||..|.  .. .|. | ..|........|  |||.|..  || |.|.
lgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy

0051082 (Phosphotyrosine protein) phosphatases II 328-527 3.6e-30 99.9 In-house 3-149 (151) alignment
Range on Protein: 328-527
Range on HMM: 3-149/151.0
SDYINAVFLHVRmernaFIATQHPLQhtieDFWRMVTDYDIGTIVMLNNLHEHDqEYPQYLPVEGatkyghirvsllskqekgdvistklkvtrnkktHE
|||||. ..  .     ......||.    ||.... ...| |||.|....|..  .|.||| .|                                 .|
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg.................................ie

VRHLHHVSWPDKCIPEVARSVLDLLDEVQAsqqqCGNAPVLVQCSNGVGRSGTFCAISSVIERlkteqvIDVFQVIKRIRANRPGAVESLTQYVFCYQII
|.|.. ..|||  .|.   .||..|.....    ..| |||| || |.||.||..|.  ....      ........ .|. |||.| . .|..|... .
vlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfal





subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 331-520 1.9e-28 94.1 In-house 78-270 (301) alignment
Range on Protein: 331-520
Range on HMM: 78-270/301.0
INAVFLHVRMERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHD-QEYPQYLPVEGATKYGHIRVSLL--SKQE--KGDVISTKLKVTRN---
| | ..    . . ||||| ||. | |||| |.. ||. .|||| .  |.  .   .||||. . |    | ..   .|.   . ...  .|.|.     
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

KKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQqcgnaPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQY
 .|. | |  ...|.|. .|.    . ||.. |. |..     |..|.||.|.||| .| .   .  ...... |.. . .|..| .|  .|   .| 
fatrtvthyqysewtdrgvPkshaelfdlmelvkksek.....PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 337-531 1.4e-12 40.9 In-house 110-309 (346) alignment
Range on Protein: 337-531
Range on HMM: 110-309/346.0
HVRMERNAFIAtQHP---LQHTIEDFWRMVTDYDIGTIVML-NNLHEHDQEYPQYLPVEGATKY-GHIRVSLLSKQEKGDVISTKLKVTRNKKTHEV--R
 ...|..  .| | |    .  .|||| |. . .|  . ..  . . ..     .   .|  .| |.. .     .  ||     ..|  . ..  |  .
ifqfehkliva.qlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicq

HLHHVSWPDKCIPEVARSVLDLLDEVQaSQQQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQK
  ||  |     |  .  .. .. .   |..|  || | |    | ||. .|      |..|      ......| |. .|||.|||..||   | |.  
vhhhapwkhlqqppktlpiikmihqfl.sekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfd

YL
|.
yi

0049260 (Phosphotyrosine protein) phosphatases II 341-525 1.9e-35 117.1 In-house 7-144 (152) alignment
Range on Protein: 341-525
Range on HMM: 7-144/152.0
ERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQEYPQYLPvegatkyghirvsllskqekgdvistklkvtrnkkthevrHLHHVSWPDKC
  ..|||||.|. .|..|||||. ...|.|||||..|.| . ..  ...                                        . .|. ||| .
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi........................................qylhlpwpDhg

IPEVARSVLDLLDEVQASqQQCGNAPVLVQCSNGVGRSGTFCAISSVIerlkteQVIDVFQVIKRIRANRPGAVESLTQYVFCYQ
 |. .  .|.||. ..   ..  . |||| || ||||.||..|.  ..      . ..........|. |||||..  |. |.|.
vpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 341-429 1.9e-14 47.8 In-house 234-321 (440) alignment
Range on Protein: 341-429
Range on HMM: 234-321/440.0
ERNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHehDQEYPQYLPVEG-ATKYGHIRVSLLSKQEKGDVISTKLKVTRNKKTHEVR
 .||||||| ||. |. ||||.| || | ||.|||.|   |.    | ||.  .  .| . |     ..   |    |..  ... ||.|
kknafiatqmpldstvldfwrlvhdyristiimlnqln..dktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheir

subfamily_PTPRD_pd Subfamily PTPRD 342-537 1.4e-76 253.4 In-house 90-287 (564) alignment
Range on Protein: 342-537
Range on HMM: 90-287/564.0
RNAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQ-EYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKV--TRNKKTHEVRHLHHVSWPD
|.|.||||.||..|||||||||..... |||||..|.|... .. .| | .| ..||.. |.| ...|. |.. ...|.  .......|||. |..||||
rkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPd

KCIPEVARSVLDLLDEVQASQqQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYLDSFSDY
...|| |.|.|||...|.|.. .... |..|.||.||||.|||..|....||.|.|...|..|..|..|..|.  |.. .||.|....|...|..... 
hgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 343-526 1.9e-32 107.1 In-house 5-199 (199) alignment
Range on Protein: 343-526
Range on HMM: 5-199/199.0
NAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQ-EYPQYLPV--EGATKYGHIRVSLLSKQEKGDVISTKLKVTRNK----KTHEVRHLHHVS
  .|||||||..|. |||.|| .   | |||.|.     . .|| | |.   |..||| . |.  .   | |   | | .| |      | |. |    |
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKCIPEVARSVLDLL--DEVQASQQQCGNAPVLVQCSNGVGRSGTFCAISSVI---ERLKTeQVIDVFQVIKRIRANRPGAVESLTQYVFCYQI
| .|  |.||  |  ..   ||    .|  .|||.|.||.| | .| | |.   .   |  ||  |.|.|.| ||.|  | | . || .| | ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyqv

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 343-526 2e-32 107.0 In-house 4-198 (198) alignment
Range on Protein: 343-526
Range on HMM: 4-198/198.0
NAFIATQHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHDQ-EYPQYLPV--EGATKYGHIRVSLLSKQEKGDVISTKLKVTRNK----KTHEVRHLHHVS
  .|||||||..|. |||.|| .   | |||.|.     . .|| | |.   |..||| . |.  .   | |   | | .| |      | |. |    |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDKCIPEVARSVLDLL--DEVQASQQQCGNAPVLVQCSNGVGRSGTFCAISSVI---ERLKTeQVIDVFQVIKRIRANRPGAVESLTQYVFCYQI
| .|  |.||  |  ..   ||    .|  .|||.|.||.| | .| | |.   .   |  ||  |.|.|.| ||.|  | | . || .| | ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyqv

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 349-530 4.6e-21 69.5 In-house 97-287 (302) alignment
Range on Protein: 349-530
Range on HMM: 97-287/302.0
QHPLQHTIEDFWRMVTDYDIGTIVMLNNLHEHD-QEYPQYL--PVEGATKYGHIRVSLLSKQEKGDVIS-------TKLKVTRNKKT----HEVRHLHHV
  | . |.| .| .. .|... .| | .. | . . . .|    |.|  |.|.  |  .| ... .  .        ..... .||.    . |  |.. 
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

SWPDKCIPEVARSVLDLLDEVQASQQQcgnapVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKY
.|||.  |. | . ||.|   .. ...     ||| ||.||||.||. ||   |.  ....| |. .... .|. | ||| . .| ..   .. | 
awpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkg

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 352-528 1.4e-22 75.0 In-house 39-218 (255) alignment
Range on Protein: 352-528
Range on HMM: 39-218/255.0
LqhTIEDFWRMVTDYDIGTIVMLNNLHEH-DQEYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVT----RNKKTHEVRHLHHVSWPDKCIPEVAR
|  |.. |....   .  ..||| ...|.  ..  .|.|.|   |     |.. . .   ||.   |..|    . ||||.|.| ..  |..|  || ||
l..tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar

SVLDLLDEVQASQqqcgnaPVLVQCSNGVGRSGTFCAISSVIE----RLKTEQV--IDVFQVIKRIRANRPGAVESLTQYVFCYQIIQ
 .| .|  |. |.      .|.|.||.|.||| .|  . .|       |.| .   .|  .... .| .|..|..   |  |.  .. 
eilnilkvvrdsk......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl

subfamily_hpo-7_pd Subfamily hpo-7 352-527 3e-20 67.2 In-house 43-223 (263) alignment
Range on Protein: 352-527
Range on HMM: 43-223/263.0
LQHTIEDFWRMVTDYDIGTIVMLNNLHEHD-QEYPQYLPVEGATKYGHIRVSLLSKQEKGDVISTKLKVTR----NKKTHEVRHLHHVSWPDKCIPEVAR
|  ||. |....      ..||| . .|.. ..  .|.|.|   |     |.. . . . ||.   |...      ||||.|.|  .. |..|  || ||
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

SVLDLLDEVQASQqqcgnaPVLVQCSNGVGRSGTFCAISSVIE----RLKTEQV--IDVFQVIKRIRANRPGAVESLTQYVFCYQII
..| .|. .. |.      .. | ||.|.|||  |  . .|       |.| .   .|  .... .| .|..|..   |  |   ..
eilnilkvarnsk......slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmv

0048179 (Phosphotyrosine protein) phosphatases II 401-525 7.5e-22 73.0 In-house 22-139 (144) alignment
Range on Protein: 401-525
Range on HMM: 22-139/144.0
VSLLSKQEKGDVISTKLKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQqcGNAPVLVQCSNGVGRSGTFCAISsvieRLKTEQvIDVF
. || |.  . ||.   .   .  ..|. ...|..||| ..|. .  .|..|. ... ..   . |||| || ||||.||..|.     ..|... ....
lellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsle

QVIKRIRANRPGAVESLTQYVFCYQ
......|. |||||..  |. |...
ealalvrsrrpgavpnpgqlrfLle

0048076 (Phosphotyrosine protein) phosphatases II 403-530 5e-22 73.6 In-house 36-142 (145) alignment
Range on Protein: 403-530
Range on HMM: 36-142/145.0
LlskqekgdvistklKVTRNKKTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQcgNAPVLVQCSNGVGRSGTFCAISSVIErlktEQvIDVFQV
|                ...  .... ......||| ..|. .. .|..|. ... ...  . |||| || ||||.||..|.  ...    .. ......
l..............tselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleea

IKRIRANRPGAVESLTQYVFCYQIIQKY
....|. |||||..  |. |.|. ....
lelvrsqrpgavpnpgqlrflyefelel

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 408-530 4.2e-11 37.2 In-house 200-343 (350) alignment
Range on Protein: 408-530
Range on HMM: 200-343/350.0
EKGDVISTKLKVTRnkkTHEVRHLHHVSWPDKC---IPEVARSVL----DLLDEVQASQ--QQCGNAPVLVQCSNGVGRSGTFCAISSVIE---RLK---
....... .| ..     ..| .|.   |.|      ||   ..|    ||.|.  | .  ..   .|.|| || |||| ||.... |...    |.   
dnnsltaitlaasd...PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenlt

T--------EQVID-VFQVIKRIRANRPGAVESLTQYVFCYQIIQKY
          .. | ........|  |   | .|.|..|.|. .. |
kesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfy

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 424-528 3.2e-22 73.5 In-house 87-191 (440) alignment
Range on Protein: 424-528
Range on HMM: 87-191/440.0
KTHEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFC
... ... |. .|||| .|..|  || ....|. ||...||.|.||.|| |.||.|   |. |..   |  . ||.| .|. .| |||  |..  ||.| 
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

YQIIQ
.. . 
heavl

0038934 (Phosphotyrosine protein) phosphatases II 426-529 5.1e-07 25.0 In-house 77-175 (194) alignment
Range on Protein: 426-529
Range on HMM: 77-175/194.0
HEVRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCGNAPVLVQCSNGVGRSGTFCAISsVIERLKTeqviDVFQVIKRIRANRPGAVESLTQYVFCYQ
    . ..  .||.. .     .|. || |.   ... .  |.| |  |.||.||..|    |.||.     .. . |...|  ||||...  ..   ..
kagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaY.Liyrlgm....saeeAialfrekRpgaipnqdyleallk

IIQK
  . 
ryke

PTPc_DSPc_SM00012 428-528 1.5e-33 110.4 In-house 2-104 (105) alignment
Range on Protein: 428-528
Range on HMM: 2-104/105.0
VRHLHHVSWPDKCIPEVARSVLDLLDEVQASQQQCG-NAPVLVQCSNGVGRSGTFCAISSVIERLKTE-QVIDVFQVIKRIRANRPGAVESLTQYVFCYQ
|.|.|. .|||...|| . |.|.||..|. ...... ..||.|.||.||||.|||.|.. ....|..| . .|.||..|..|  |||.|....||.|.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

IIQ
...
all

subfamily_DSP23_pd Subfamily DSP23 431-525 2.3e-06 22.3 In-house 54-140 (148) alignment
Range on Protein: 431-525
Range on HMM: 54-140/148.0
LHHVSWPDKCIPEVArSVLDLLDEVQASQQQcgNAPVLVQCSNGVGRSGTFCAISSVierlkTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQ
|...  .| . | .   | ...  |. ....  |  | | |  | ||.||. |   |      |. .   . |  .|  |||.||.. |    ..
lvrlriddyhppale.qvvefvrvveeaeek..neavsvhcllgrgrtgtmlacylv.....kerklaaaeaiaevrrlrpgsvetveqeklvrd

subfamily_CDKN3_pd Subfamily CDKN3 431-529 2.5e-06 21.2 In-house 102-194 (202) alignment
Range on Protein: 431-529
Range on HMM: 102-194/202.0
LHHVSWPDKCIPEVArSVLDLLDEVQASQQQCgnAPVLVQCSNGVGRSGTFCAIssVIerLKTEQVIDVFQVIKRIRANR-PGAVESLTQYVFCYQIIQK
 ||   .|  .|..| | |..|.|.. . ..      || |  |.|||    |   ..  |  ...|.  . |...|  .  .|.... || .  .. .|
vhhypiadglvpdia.sclkileelrinlkay..rktlvhcygglgrsslviac..ll..lylddtiepkdaidklrdlkgsraiqtvkqynylsefrdk





subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 450-531 2.1e-07 24.6 In-house 249-344 (349) alignment
Range on Protein: 450-531
Range on HMM: 249-344/349.0
DLLDEVQAS--QQQCGNAPVLVQCSNGVGRSGTFCAISSVIER----------LKTEQ-VID-VFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
||.|.  |    ..   ...|| || | ||.|... . ....           .| ..   | .. ..  .|  |   |. |.|....|. . ||.
dliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf

subfamily_CG42327_pd Subfamily CG42327 459-531 1.3e-13 45.3 In-house 242-315 (319) alignment
Range on Protein: 459-531
Range on HMM: 242-315/319.0
QQQCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTE-QVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQKYL
 ..  . |. | ||.||||.|.  |    |..|..  . .|. |..  .| .|  || .  || | |.....| 
gtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 461-529 2e-12 41.6 In-house 225-293 (297) alignment
Range on Protein: 461-529
Range on HMM: 225-293/297.0
QCGNAPVLVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQIIQK
.  ||..|| || ||||||       ....|. ... ||  ... .| .|.  |..| |. ..|... |
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 468-526 8e-12 39.4 In-house 2-60 (69) alignment
Range on Protein: 468-526
Range on HMM: 2-60/69.0
LVQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQI
.|.|| | ||.||| ||   . |.|.|...|.|  .. .|  ||  |    .|.| .  
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihda

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 469-526 2.9e-11 37.5 In-house 2-59 (69) alignment
Range on Protein: 469-526
Range on HMM: 2-59/69.0
VQCSNGVGRSGTFCAISSVIERLKTEQVIDVFQVIKRIRANRPGAVESLTQYVFCYQI
|.|| | ||.||| ||   . |.|.|...|.|  .. .|  ||  |    .|.| .. 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihda