Gene NvecPTP-sf2-12 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP055_AA protein Get Run
NvecP055_AA_0-59 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1-65 1.1e-27 92.1 In-house 233-297 (298) alignment 
Range on Protein: 1-65
Range on HMM: 233-297/298.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFLDSFSDYA
| ||||| .|. ||..|||.|.||||||.|||||..|||||.. .||||.|||.. .||||.|..
GvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1-66 9.4e-24 79.0 In-house 185-250 (250) alignment 
Range on Protein: 1-66
Range on HMM: 185-250/250.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFLDSFSDYAN
| ||||. .|. .|..|.| |.|||||. .||||. ||.||||| ||||.||. . .|||..|||.
GvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
subfamily_PTPRD_pd Subfamily PTPRD 1-64 1.5e-19 65.1 In-house 224-287 (564) alignment 
Range on Protein: 1-64
Range on HMM: 224-287/564.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFLDSFSDY
| ||.|| ... ....|.|.|..||..| || ||. |.  |..  ||.|..|| . .|..... 
GVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
0050432 (Phosphotyrosine protein) phosphatases II 1-65 2.6e-19 65.1 In-house 242-306 (308) alignment 
Range on Protein: 1-65
Range on HMM: 242-306/308.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFLDSFSDYA
| ||.||..|.. .......|. ||||.||| ||  |||.|... ||.|.|.| . .| ..  ..
GvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-62 4.3e-19 63.7 In-house 226-287 (319) alignment 
Range on Protein: 1-62
Range on HMM: 226-287/319.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFLDSFS
|.|| || ...  ...||| | |.|||. |. ||. |.  |.   || |.||| ........
GvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_PTPRA_pd Subfamily PTPRA 1-57 2.5e-18 61.1 In-house 238-294 (330) alignment 
Range on Protein: 1-57
Range on HMM: 238-294/330.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAF
|.||.||.... .|..|||||..||||..|| ||. ||  | .. ||.|.|.. . .
GvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
0046845 (Phosphotyrosine protein) phosphatases II 1-65 2.7e-18 61.8 In-house 214-281 (284) alignment 
Range on Protein: 1-65
Range on HMM: 214-281/284.0
GAGRSGTLCAVLSVIDRVKAEH---VVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFLDSFSDYA
| ||.||..|.  .......|.   .|||..||| ||  |||.|..| ||.|.||| . .| ..  ..
GvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1-66 3.2e-18 60.9 In-house 223-288 (318) alignment 
Range on Protein: 1-66
Range on HMM: 223-288/318.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFLDSFSDYAN
| || |. .|| ....|.||| .||||| || ||  |.  |    ||.|.|.. . .| |.  ...
GvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
0051299 (Phosphotyrosine protein) phosphatases II 1-57 9.4e-18 60.1 In-house 229-285 (288) alignment 
Range on Protein: 1-57
Range on HMM: 229-285/288.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAF
| ||.||..|.. .......|..|||..||| ||  |||.|... ||.|.||| . .
GvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1-59 1.7e-17 58.5 In-house 226-284 (305) alignment 
Range on Protein: 1-59
Range on HMM: 226-284/305.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFLD
| ||.|. .||   ..|.|.| |||||. .| || .|...|..| ||||...|    . 
gvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
0036941 (Phosphotyrosine protein) phosphatases II 1-58 1.9e-17 58.9 In-house 217-277 (297) alignment 
Range on Protein: 1-58
Range on HMM: 217-277/297.0
GAGRSGTLCAVLSVIDRVK---AEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFL
| |||||..|.  ......    |. ||...||| ||  |||||..| ||.|.||| . .|
GvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0047943 (Phosphotyrosine protein) phosphatases II 1-57 2.3e-17 58.8 In-house 215-271 (273) alignment 
Range on Protein: 1-57
Range on HMM: 215-271/273.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAF
| ||.||..|.. ..|....|. |||..||| ||  |||.|... ||.|.||| . .
GvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
subfamily_PTPRK_pd Subfamily PTPRK 1-55 3.2e-17 57.3 In-house 220-274 (314) alignment 
Range on Protein: 1-55
Range on HMM: 220-274/314.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATM
||||.|| .|. .|.| .. |.|||||.||| ||....  ||   ||.|.|.. .
GaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvil
0040438 (Phosphotyrosine protein) phosphatases II 1-58 4.4e-17 57.8 In-house 219-276 (317) alignment 
Range on Protein: 1-58
Range on HMM: 219-276/317.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFL
| ||.||..|.. ...... |. |||..||| ||. |||||... ||.|.|.| . .|
GvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
Y_phosphatase Protein-tyrosine phosphatase 1-55 7.5e-17 56.9 Pfam-A 180-234 (235) alignment 
Range on Protein: 1-55
Range on HMM: 180-234/235.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATM
|.||.||..|.  ......||. |||.|.|| ||..|||.|.|| ||.|.|.| .
GvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1-55 7.5e-17 56.9 In-house 180-234 (235) alignment 
Range on Protein: 1-55
Range on HMM: 180-234/235.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATM
|.||.||..|.  ......||. |||.|.|| ||..|||.|.|| ||.|.|.| .
GvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0039614 (Phosphotyrosine protein) phosphatases II 1-60 7.6e-17 57.1 In-house 232-291 (297) alignment 
Range on Protein: 1-60
Range on HMM: 232-291/297.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFLDS
| ||.||..| . ...... |. |||..||| ||  |||||... ||.|.|.| . .|  
GvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0043336 (Phosphotyrosine protein) phosphatases II 1-55 2.6e-16 55.4 In-house 220-274 (278) alignment 
Range on Protein: 1-55
Range on HMM: 220-274/278.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATM
| ||.||..|.. ...... |. ||...||| ||  |||||... ||.|.||| .
GvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
DSPc_SM00195 1-58 3.8e-16 54.6 In-house 205-262 (263) alignment 
Range on Protein: 1-58
Range on HMM: 205-262/263.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFL
| ||.||.... ........|. ||.|. || || .|||.|..| || |.||| ....
GvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1-58 3.8e-16 54.6 In-house 205-262 (263) alignment 
Range on Protein: 1-58
Range on HMM: 205-262/263.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFL
| ||.||.... ........|. ||.|. || || .|||.|..| || |.||| ....
GvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_CG7180_pd Subfamily CG7180 1-55 4.3e-16 53.4 In-house 233-287 (296) alignment 
Range on Protein: 1-55
Range on HMM: 233-287/296.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATM
||.|||  .|.   .. |. |. ||||.||| || |||. ||.  .| ..|.   
GasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll
0042113 (Phosphotyrosine protein) phosphatases II 1-57 6.6e-16 53.9 In-house 186-242 (245) alignment 
Range on Protein: 1-57
Range on HMM: 186-242/245.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAF
| ||.||..|.. .......|. |....||| ||  |||||... ||.|.||| . .
GvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
PTPc_DSPc_SM00012 1-55 7.2e-16 53.7 In-house 49-104 (105) alignment 
Range on Protein: 1-55
Range on HMM: 49-104/105.0
GAGRSGTLCAVLSVIDRVKAE-HVVDVFQAVKVLRASRPGAVESLRQYVFCYEATM
|.||.||..|.  .......| . ||.|| || || .|||.|....||.|.|.| .
GvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyrall
0045450 (Phosphotyrosine protein) phosphatases II 1-56 8.1e-16 54.1 In-house 244-302 (307) alignment 
Range on Protein: 1-56
Range on HMM: 244-302/307.0
GAGRSGTLCAVLSVIDRVKAEHV---VDVFQAVKVLRASRPGAVESLRQYVFCYEATMA
| ||.||..| . .......|..   ||...||| ||. |||||... ||.|.||| . 
GvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_Ptp69D_pd Subfamily Ptp69D 1-58 1.7e-15 51.9 In-house 229-286 (307) alignment 
Range on Protein: 1-58
Range on HMM: 229-286/307.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFL
|.||||.. |. |.....|||. ||.|. || ||  |.  |.||.||||.| | . . 
GvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys
0040439 (Phosphotyrosine protein) phosphatases II 1-55 2.3e-15 52.3 In-house 189-243 (249) alignment 
Range on Protein: 1-55
Range on HMM: 189-243/249.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATM
| ||.||..| . ...... |. ||...||| ||  |||||... ||.|.||| .
GvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1-55 1.1e-14 49.1 In-house 222-276 (315) alignment 
Range on Protein: 1-55
Range on HMM: 222-276/315.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATM
| ||.||.... .|.|...||...||..... .|. | ..|... || | |.| .
GvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1-59 1.3e-14 48.9 In-house 222-282 (288) alignment 
Range on Protein: 1-59
Range on HMM: 222-282/288.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFL--D
| ||.||  |.  .||.|..| ..||. .|. || .|.  |. |.||.|.||. .     |
GvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieed
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1-58 1.4e-14 48.6 In-house 220-277 (315) alignment 
Range on Protein: 1-58
Range on HMM: 220-277/315.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFL
|.||.| .... .|....| ...||||. || ||| ||  | .  .| | |.| .  |
GvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
0045098 (Phosphotyrosine protein) phosphatases II 1-56 1.7e-14 49.4 In-house 216-270 (278) alignment 
Range on Protein: 1-56
Range on HMM: 216-270/278.0
GAGRSGTLCAVLSVIDRVkaEHVVDVFQAVKVLRASRPG-AVESLRQYVFCYEATMA
| ||.|||.|.  .....  |..||...||| ||  ||| ||..| ||.|.||. . 
GvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1-60 4.2e-14 47.4 In-house 227-286 (297) alignment 
Range on Protein: 1-60
Range on HMM: 227-286/297.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFLDS
| || | |....||. ..| |. ||.|. || || .||  |    || | |.| . .| |
GvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
0051429 (Phosphotyrosine protein) phosphatases II 1-61 5e-14 48.1 In-house 160-228 (272) alignment 
Range on Protein: 1-61
Range on HMM: 160-228/272.0
GAGRSGTLCAVLSVIDRVKAEHVVD--------VFQAVKVLRASRPGAVESLRQYVFCYEATMAFLDSF
| .|.||..|.| .. .| .| .||        ...||. ||| |||||..  ||.|.||| ...|.|.
GkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1-57 6.7e-14 46.7 In-house 231-287 (325) alignment 
Range on Protein: 1-57
Range on HMM: 231-287/325.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAF
| ||.|.. .. |....|  |  ||.|. || ||. ||  ||.  ||...||| . .
GvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1-57 2.6e-13 43.9 In-house 219-275 (515) alignment 
Range on Protein: 1-57
Range on HMM: 219-275/515.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAF
|.|| | .... ||. ..|  ..||||. |...|. ||  |    || | |.| .  
GvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavled
0037934 (Phosphotyrosine protein) phosphatases II 1-55 2.7e-13 45.5 In-house 188-239 (243) alignment 
Range on Protein: 1-55
Range on HMM: 188-239/243.0
GAGRSGTLCAVLSVIDRVkaeHvVDVFQAVKVLRASRPG-AVESLRQYVFCYEATM
| ||.|||.| . .....   . ||...||| ||. ||| ||... ||.|.||| .
GvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1-64 3.6e-13 44.5 In-house 234-298 (319) alignment 
Range on Protein: 1-64
Range on HMM: 234-298/319.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMA-FLDSFSDY
|.||.|.  ..  ..||.| |. |||.. |. ||  |.  |..| || |.| | .  .| ..|| 
GvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1-64 5.9e-13 43.9 In-house 198-262 (284) alignment 
Range on Protein: 1-64
Range on HMM: 198-262/284.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMA-FLDSFSDY
|.||.|.  ..  ..||.| |. |||.. |. ||  |.  |..| || |.| | .  .| ..|| 
gvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdv
subfamily_PTPN13_pd Subfamily PTPN13 1-60 6.7e-13 43.5 In-house 212-271 (273) alignment 
Range on Protein: 1-60
Range on HMM: 212-271/273.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFLDS
| |||||| ..  |.. .. .. .|| . |. ||  | | | .  ||.|.|.|..  | |
GiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1-55 7.5e-13 43.0 In-house 209-263 (283) alignment 
Range on Protein: 1-55
Range on HMM: 209-263/283.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATM
| ||.....|. . .. ...| |||||. ||..|  |..|| .| || . .|. .
giGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1-55 9.1e-13 42.8 In-house 202-256 (267) alignment 
Range on Protein: 1-55
Range on HMM: 202-256/267.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATM
| |||||.  . | ..|.| | |.|.|. .. .|  |.| |... .|....|   
GvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihella
subfamily_PTPRG_pd Subfamily PTPRG 1-59 1.3e-12 41.7 In-house 230-288 (563) alignment 
Range on Protein: 1-59
Range on HMM: 230-288/563.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFLD
|.||.||.... ... ....|..|.||. .| .|| |.  |..  ||.| ..| .  . 
GvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
0046846 (Phosphotyrosine protein) phosphatases II 1-58 1.9e-12 42.8 In-house 119-173 (176) alignment 
Range on Protein: 1-58
Range on HMM: 119-173/176.0
GAGRSGTLCAVLsvidRVKAEHVVDVFQAVKVLRASRP-GAVESLRQYVFCYEATMAFL
| ||.|||.| .     .. |. ..|..|.. .|. || |||..  || |.||. . .|
GigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefellll
subfamily_PTPN9_pd Subfamily PTPN9 1-58 3.2e-12 41.1 In-house 233-290 (297) alignment 
Range on Protein: 1-58
Range on HMM: 233-290/297.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFL
| ||.||....   ..|.. . .|||...|| ||. |  ..    ||.||| | . . 
GiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
0036282 (Phosphotyrosine protein) phosphatases II 1-52 3.8e-12 41.7 In-house 114-164 (174) alignment 
Range on Protein: 1-52
Range on HMM: 114-164/174.0
GAGRSGTLCAVLSVIDRVKaEHVVDVFQAVKVLRASRPGAVESLRQYVFCYE
| ||.|||.| . .. . . | .||... |. ||  |||.|..  || |.|.
GvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1-58 4.1e-12 40.1 In-house 228-285 (302) alignment 
Range on Protein: 1-58
Range on HMM: 228-285/302.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFL
|||| |.. ..  ......... . . . || .|. || ||.|| |||. | |.. ..
GaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1-55 4.9e-12 40.1 In-house 8-62 (69) alignment 
Range on Protein: 1-55
Range on HMM: 8-62/69.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATM
|.||.||. |..  . |.|.| .||.|  |. .|  ||  |    .|.| ..| .
gtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1-59 6.4e-12 39.6 In-house 328-386 (392) alignment 
Range on Protein: 1-59
Range on HMM: 328-386/392.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFLD
||||.| .|. .  | ..   . ||.||.||.||| |   |..  .| | |.    .| 
gagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqteeeyafvydvireylh
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1-55 7.8e-12 39.4 In-house 7-61 (69) alignment 
Range on Protein: 1-55
Range on HMM: 7-61/69.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATM
|.||.||. |..  . |.|.| .||.|  |. .|  ||  |    .|.| ..| .
GtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv
0043147 (Phosphotyrosine protein) phosphatases II 1-52 3.5e-11 38.6 In-house 110-155 (172) alignment 
Range on Protein: 1-52
Range on HMM: 110-155/172.0
GAGRSGTLCAVLSVIdrvkaeHVVDVFQAVKVLRASRPGAVESLRQYVFCYE
| ||.|||.| . ..      . .....||. .|. |||||..  || |.|.
GvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrflyy
0049260 (Phosphotyrosine protein) phosphatases II 1-52 4.4e-11 38.2 In-house 99-144 (152) alignment 
Range on Protein: 1-52
Range on HMM: 99-144/152.0
GAGRSGTLCAVLSVIdrvkaeHVVDVFQAVKVLRASRPGAVESLRQYVFCYE
| ||.|||.| . ..      . |....||. .|. |||||..  |. |.||
GvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_PTPRB_pd Subfamily PTPRB 1-60 1e-10 36.1 In-house 228-287 (293) alignment 
Range on Protein: 1-60
Range on HMM: 228-287/293.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFLDS
| ||.||. |.  ...... | .||.|  |  || .|   | . .||.| ... ...| .
GvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
0049772 (Phosphotyrosine protein) phosphatases II 1-61 2.7e-10 36.0 In-house 222-283 (314) alignment 
Range on Protein: 1-61
Range on HMM: 222-283/314.0
GAGRSGTLCAVLSVIDRVKaehvVDVFQAVKVLRASRP-----GAVESLRQYVFCYEATMAFLDSF
| ||.||....  .. . .    |.. .|.. .|. ||     |..|.|.||.|..|| . .|. .
GkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylkfl
0041856 (Phosphotyrosine protein) phosphatases II 1-55 3.1e-10 35.4 In-house 119-168 (182) alignment 
Range on Protein: 1-55
Range on HMM: 119-168/182.0
GAGRSGTLCAVLSVIDRvkaeHvVDVFQAVKVLRASRPGAVESLRQYVFCYEATM
| ||.|||.|   .. .    . |....||| .|  |||.|... ||.|.. | .
GvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlall
subfamily_PTPN12_pd Subfamily PTPN12 1-57 3.4e-10 34.3 In-house 217-276 (290) alignment 
Range on Protein: 1-57
Range on HMM: 217-276/290.0
GAGRSGTLCAVLSVIDRVKAEHV---VDVFQAVKVLRASRPGAVESLRQYVFCYEATMAF
| || ||..|.  | . .|||..   .|||. |  ||  |. .| .  ||.. |.| . .
GvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1-59 1.2e-09 32.7 In-house 211-269 (274) alignment 
Range on Protein: 1-59
Range on HMM: 211-269/274.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFLD
| || |   |..  . ....|.||||.. |  ||  | | |..  || . ..| . .| 
GiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
0048076 (Phosphotyrosine protein) phosphatases II 1-55 5.4e-09 31.4 In-house 91-140 (145) alignment 
Range on Protein: 1-55
Range on HMM: 91-140/145.0
GAGRSGTLCAVLsvidRVKAEHvVDVFQAVKVLRASRPGAVESLRQYVFCYEATM
| ||.|||.|       .. .. |....|.. .|. |||||..  |. |.||. .
GvgRtgtlvaay....lmlllg.vsleealelvrsqrpgavpnpgqlrflyefel
0051082 (Phosphotyrosine protein) phosphatases II 1-53 5.4e-09 31.3 In-house 102-148 (151) alignment 
Range on Protein: 1-53
Range on HMM: 102-148/151.0
GAGRSGTLCAVLSVIDRvkaehvVDVFQAVKVLRASRPGAVESLRQYVFCYEA
| ||.|||.|.. .. .      |....|.. .|..|||.| .  |..|.. |
GkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
0048179 (Phosphotyrosine protein) phosphatases II 1-52 9.5e-09 30.7 In-house 93-139 (144) alignment 
Range on Protein: 1-52
Range on HMM: 93-139/144.0
GAGRSGTLCAVLsvidRVKAEHvVDVFQAVKVLRASRPGAVESLRQYVFCYE
| ||.|||.|      ..| .. .....|.. .|. |||||..  |. |..|
GvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1-56 9.8e-09 29.1 In-house 222-277 (439) alignment 
Range on Protein: 1-56
Range on HMM: 222-277/439.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMA
| ||.||. |.   ....|.|  ||.   |||||  |   |..| |||| |.| . 
gvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1-59 2.1e-08 28.3 In-house 220-278 (287) alignment 
Range on Protein: 1-59
Range on HMM: 220-278/287.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFLD
|.||||.| |.| ...| .    ||| ..|  ||  | . | .  |. . ||| ...  
GiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_PTPN23_pd Subfamily PTPN23 1-56 2.3e-08 28.2 In-house 222-278 (288) alignment 
Range on Protein: 1-56
Range on HMM: 222-278/288.0
GAGRSGTLCAVLSVIDRVKAEH-VVDVFQAVKVLRASRPGAVESLRQYVFCYEATMA
| ||.|... | ...  ..... ..|. | |. ||. |   |.   |. |.||| . 
GvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_PTPN6_pd Subfamily PTPN6 1-60 4.6e-08 27.4 In-house 237-299 (306) alignment 
Range on Protein: 1-60
Range on HMM: 237-299/306.0
GAGRSGTLCAV---LSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFLDS
| || ||.  .   |..| . . .  .|. ..||..|. | | |    || | |.|  .....
GiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1-54 4.9e-08 27.4 In-house 183-236 (239) alignment 
Range on Protein: 1-54
Range on HMM: 183-236/239.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEAT
| ||.|..  . ... . | .. ||.|. || .|  ||  |..  |||| . | 
gvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1-54 5.7e-08 27.2 In-house 184-237 (239) alignment 
Range on Protein: 1-54
Range on HMM: 184-237/239.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEAT
| ||.|..  . ... . | .. ||.|. || .|  ||  |..  |||| . | 
gvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_PTPN14_pd Subfamily PTPN14 1-59 6.1e-08 27.0 In-house 239-297 (300) alignment 
Range on Protein: 1-59
Range on HMM: 239-297/300.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFLD
|.||.| |  .  .|  .. ....|. .... ||  |   |..| || | |.. . .|.
GvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1-56 6.3e-08 26.8 In-house 238-293 (297) alignment 
Range on Protein: 1-56
Range on HMM: 238-293/297.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMA
| |||| .     ...... ... ||   ...||  |.  |..|.|. ..|.|...
GvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_CG42327_pd Subfamily CG42327 1-57 8.8e-08 26.2 In-house 257-314 (319) alignment 
Range on Protein: 1-57
Range on HMM: 257-314/319.0
GAGRSGTLCAVLSVIDRVKAE-HVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAF
|.||.|.. |    | ...   . ||. | |  .|  |  || .  || | |     .
GvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1-60 1.4e-07 25.9 In-house 218-278 (281) alignment 
Range on Protein: 1-60
Range on HMM: 218-278/281.0
GAGRSGTLCAVLSVIDRVKAE-HVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFLDS
| ||.||  |.  ....|.|| . .|| . |. || .|   | .. || | | | .  || 
GvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1-59 1.4e-07 25.8 In-house 207-265 (270) alignment 
Range on Protein: 1-59
Range on HMM: 207-265/270.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFLD
| ||.||| |.  ..  .. .. ||| . .. ||  |.  |.  .|| | |.| . . .
GvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
0044763 (Phosphotyrosine protein) phosphatases II 1-53 1.5e-07 26.7 In-house 120-166 (178) alignment 
Range on Protein: 1-53
Range on HMM: 120-166/178.0
GAGRSGTLCAVLSVIDRvkaeHVvDVFQAVKVLRASRPgAVESLRQYVFCYEA
| ||||||.|   .. .    .. ....|.. .|. || .|..  |. ..|| 
GvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyef
subfamily_PTPRN_pd Subfamily PTPRN 1-54 1.8e-06 21.9 In-house 234-288 (297) alignment 
Range on Protein: 1-54
Range on HMM: 234-288/297.0
GAGRSGTLCAVLSVIDRV-KAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEAT
||||.|. ...  |..|. |  . .|.  ... ||  ||| |..  |. |.. | 
GaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1-55 2.8e-06 21.6 In-house 214-268 (288) alignment 
Range on Protein: 1-55
Range on HMM: 214-268/288.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATM
|.||.|||  .| ... .. .  . . . .. ||..|  |...  ||.. .   .
GvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvl
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1-49 4.1e-06 20.5 In-house 231-279 (302) alignment 
Range on Protein: 1-49
Range on HMM: 231-279/302.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVF
| ||.||| |.   |.  . ..| |. . |. .|. | ||| . .| ..
GvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1-55 6.6e-06 18.9 In-house 252-306 (346) alignment 
Range on Protein: 1-55
Range on HMM: 252-306/346.0
GAGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATM
|.||. ..   |  |...      .... .| ..  |||.|||. ||   |   .
gcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivf
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2-64 2.6e-15 51.0 In-house 227-289 (290) alignment 
Range on Protein: 2-64
Range on HMM: 227-289/290.0
AGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFLDSFSDY
 |||...||.   |...| | |.|||| .| .|  .|| |..  || . ..  .  ||||. |
vgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2-67 1e-14 49.2 In-house 222-287 (287) alignment 
Range on Protein: 2-67
Range on HMM: 222-287/287.0
AGRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFLDSFSDYANF
 |||...||.   |...| | |.|||| .|  |  .||.|   .|| | ... ...||||. |..|
vGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 3-66 1.4e-17 58.3 In-house 238-301 (301) alignment 
Range on Protein: 3-66
Range on HMM: 238-301/301.0
GRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATMAFLDSFSDYAN
.|||. |.|   .. .||| |||||| .| .| |.||||  | ||.. |..   .|   | |||
srsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 3-52 6.7e-11 36.2 In-house 383-432 (440) alignment 
Range on Protein: 3-52
Range on HMM: 383-432/440.0
GRSGTLCAVLSVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYE
  || .|.|. ...... .  .|||| ...|| |||  | .| .|..|| 
eesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdyllcyk
subfamily_ptpA1_pd Subfamily ptpA1 13-55 1.3e-06 22.4 In-house 353-395 (418) alignment 
Range on Protein: 13-55
Range on HMM: 353-395/418.0
SVIDRVKAEHVVDVFQAVKVLRASRPGAVESLRQYVFCYEATM
...|. ..   ...|  |  ||  ||| |. | ||.|||.. .
aimdkynsridfnlfsivlklreqrpgmvqqleqylfcyktil