Gene NvecPTP-sf3-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf3
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP057_AA protein Get Run
NvecP057_AA_5-204 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 3-204 1.1e-47 157.7 In-house 92-285 (298) alignment 
Range on Protein: 3-204
Range on HMM: 92-285/298.0
LQDHKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTesGTGKYGSMSVTTKTITTKPDYTITALILTNNTTAppSTREI
|. .||.  .||||.|. ||..|||.||.|  .| |||... .  .. .|. |||..  |. .||...|. .   .. |.... |........  ..||.
lhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkkee..kerev

SHYQFTSWKEKTTPNVALFVgfVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEesKTSVVDLFEVAKRLRQARCGIISSLPHYNFIY
 . .|||| .|..|..|  |  .   |.| .. .| ...||||.||.| | .| |.|.|  .   .  | .|||.|.| |.||. |.|.. .  .| |||
rqlhftsWpdkgvpenatsv..ldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervk..keqvvDvfqvvkvlRkkrpgavqteeqYvfiy

QV
..
ea
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 3-204 3.2e-41 136.1 In-house 84-278 (290) alignment 
Range on Protein: 3-204
Range on HMM: 84-278/290.0
LQDHKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTgkYGSMSVTTKTITTKPDYTITALILTNNTTApPSTREI
....| ...||||| |. .|..|||...|.  .  |||. . .....     |||.... .  || .|..    .|  .|... | ..|...|  .....
ikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikllneetlneyierklevknknsa.gakqsv

SHYQFTSWKEKTtpNVALFVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEesKTSVVDLFEVAKRLRQARCGIISSLPHYNFIY
 .||.|.|...   .|.   . ... .|. |.  .. . ...|||||. | ..||.|.....   .  .. |.|.|.| |..|. . | . .  .|..|.
tqyqitnwdstg..kvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkck..tegvidvfqvlksqRiqkpgsvqtvqqyqgif

QV
|.
qi
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 3-204 7.6e-41 135.0 In-house 83-274 (288) alignment 
Range on Protein: 3-204
Range on HMM: 83-274/288.0
LQDHKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTgKYGSMSVTTKTITTKPDYTITALILTNNTTappsTREI
....|....||||| |. .|. |||..|.|. .  |||...   . .     |||...  . .|||. || .   .. |..   |.|  ..|     .||
idgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpk.nyGsvtvtlveskeledfvlrklllekkkt....elei

SHYQFTSWKEKTTPNVAL-FVGFVvasREVsKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEEskTSVVDLFEVAKRLRQARCGIISSLPHYNFI
 .||...| ..  |. .  .....   | | |  .|..  |.|||||.| | ||.|.|||  .   ||  . ..|.... ..||. |  ..  | .| ||
tqyqylaWpdhgvPeskapllell...rqv.kvanqadtgpiivhCsaGvGrtgtFialdalidavee..edyiDvagtvaklRkqRallvqtlkqYefi

YQV
|.|
yev
subfamily_PTPN12_pd Subfamily PTPN12 3-203 1.2e-34 114.5 In-house 76-271 (290) alignment 
Range on Protein: 3-203
Range on HMM: 76-271/290.0
LQDHKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTITTKP-DYTITALILTNNttapPSTRE
..  .|. .|||.| |. .|. |||.|.||.    .||.     ..      ||| .   . ..|...||...  .   |..| .| ....      .|.
ikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq....kesrk

ISHYQFTSWKEKTTPNVALFvgfVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKT-SVVDLFEVAKRLRQARCGIISSLPHYNF
.  ...|.| .. .|. |     ...  |  .......|||..|||| | | ||. .|.|.  .  .. |. . .|.|..  .||. |  .. .   |..
vyqfhYtaWPDhgvPssaks...llelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyel

IYQ
.|.
vyk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 3-203 2.7e-29 97.3 In-house 84-282 (325) alignment 
Range on Protein: 3-203
Range on HMM: 84-282/325.0
LQDHKGQRRYIATQHPMRETMADFWQMV--WEtgSGHIVMVNDDQKNKEaDYPFYWPTTESGTGKYGSMSVTTKTITTKPDYTITALILTNNTTapPSTR
|.|.|..  ..|.| |. .|. |.|..|  |.  .  .|..|  ...|.     |||   . . ..|.. |  .|| .  ||    | . .       ||
lrddkkkdvflaaqaPltatindlWrlvldWr..csvvvvlneldlgkd.rcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkk..Getr

EISHYQFTSWKEKTTPNV-ALFVGFVVASREVSKKYEQ--EKDAPVIVHCSDGQGFTGVFVALDIGVRshEESKTSVVDLFEVAKRLRQARCGIISSLPH
 .  .|. ||..  ...  | .. ..    .||..     .  .|..||||.| | ||||..|   .   .  . | ||.|.. |.||. |  .. .   
svkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysala..kvieesrvdifgfvkklrkdrpsmvetvdq

YNFIYQ
| .||.
yiliye
subfamily_PTPRB_pd Subfamily PTPRB 4-203 3.7e-41 136.1 In-house 88-279 (293) alignment 
Range on Protein: 4-203
Range on HMM: 88-279/293.0
QDHKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTgKYGSMSVTTKTITTKPDYTITALILTNnttaPPSTREIS
.... .| .|||| |. ||. |||.||||. |  |||. .   .       |||..|. .  ||...|| .. ... |..|  | ...      ..|.. 
pgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiek....ekeerkvr

HYQFTSWKEKTTPNVA-LFVGFVVASREVSKKyeQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEEskTSVVDLFEVAKRLRQARCGIISSLPHYNFIY
.|.|||| .   |. .  .. || . ||. .|  .....|..|||| | | ||.|.|||  ... ||  . .||.| .  .||. |. .. .  .| ||.
qyhftsWpdhgvPektktlldfvrtvreaiek..taskrPivvhCsaGvGRtGtfialdrllqaiee..edyvdifgivaelReeRnllvqtekqYifih

Q
|
q
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 4-203 1.3e-40 134.0 In-house 69-260 (283) alignment 
Range on Protein: 4-203
Range on HMM: 69-260/283.0
QDHKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTteSGTGKYGSMSVTTKTITTKPDYTITALILTNNTTAPpSTREIS
...| ...||..| |...|. |||.||..     |||.   | ...     |||    |. .|| . || .  ||.  ..|  |.| .|..|  ||  ..
ksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk..rGsedyGeftvtlrkettsnsfiikelllrvnssak.stllla

HYQFTSWkekTTPNVALFVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHeeSKTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQ
|||.  |   .  .    .  .|    |  .  ..|..|..|||| | | |.||.|.   |        ||||.|.| | .|. | ... .|  | ....
hyqvidW...leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkda..ltesvvdvfavvkimreqrmmavqtldqyklvhe
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 4-202 1e-25 85.3 In-house 45-234 (239) alignment 
Range on Protein: 4-202
Range on HMM: 45-234/239.0
QDHKGQ-RRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTesgTGKYGSMSVTTKTITTKPDYTITALILTNNTTAppSTREI
.|. |  . |||||  .  .  |||.|.|.     |||.    . ..     ||| .   | ||  . || .      || | ......   .    | .
rdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds...tskycnlrvtlrktevfadyiirtfvmsqvgqt..eeryv

SHYQFTSWKEKTTPNVALFVgfVVASREVSKkYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTsvVDLFEVAKRLRQARCGIISSLPHYNFIY
 .|.|| | .|  |. |  |  .   |...|        | ..||| | | || |. .|  .|  .. ||  ||.|.  | .|. |  .. .  .| ||.
yqyhftvwpdkgvpqyatav..lglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqkt..vdifnyvkairedrphmvqtseqyvfih
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 4-202 1e-25 85.3 In-house 44-233 (239) alignment 
Range on Protein: 4-202
Range on HMM: 44-233/239.0
QDHKGQ-RRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTesgTGKYGSMSVTTKTITTKPDYTITALILTNNTTAppSTREI
.|. |  . |||||  .  .  |||.|.|.     |||.    . ..     ||| .   | ||  . || .      || | ......   .    | .
rdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds...tskycnlrvtlrktevfadyiirtfvmsqvgqt..eeryv

SHYQFTSWKEKTTPNVALFVgfVVASREVSKkYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTsvVDLFEVAKRLRQARCGIISSLPHYNFIY
 .|.|| | .|  |. |  |  .   |...|        | ..||| | | || |. .|  .|  .. ||  ||.|.  | .|. |  .. .  .| ||.
yqyhftvwpdkgvpqyatav..lglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkqkt..vdifnyvkairedrphmvqtseqyvfih
subfamily_PTPRD_pd Subfamily PTPRD 5-204 2e-53 176.9 In-house 86-276 (564) alignment 
Range on Protein: 5-204
Range on HMM: 86-276/564.0
DHKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTeSgTGKYGSMSVTTKTITTKPDYTITALILTNNTTapPSTREISH
 .. .. |||||.|. ||..|||.||||  |  |||..  . ...  .  |||.. . | .||.. || .  ... ||.|. ..|.....   ..||. .
gyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkks..sesreVrq

YQFTSWKEKTTPNVAlfVGFVVASREVSKKYeQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEEskTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQV
..|||| ..  |. |   ...   |.|..   ...  |..|||| | | ||.|...|. ..  .|    .||.... |.||. |  .. .   | ||...
FhFtsWPdhgvpesa..tslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerike..ektvDiyqyvkalrkqRnamVqteeQYiFihea
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 5-204 2.6e-46 153.2 In-house 84-278 (305) alignment 
Range on Protein: 5-204
Range on HMM: 84-278/305.0
DHKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTITTKPDYTITALILTNNTTaPPSTREISH
 .|.. .||..| |...|.||||....|.   .|||. . .....     |||.... . ..|..||. |  .| .||..  | .... .    .| ...
gykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.dkesrtvlq

YQFTSWKEKTTPNVAlfVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHeeSKTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQV
||.|.| ..  |. |    ..   ..| |.....|. |..||||.| | ||||.|.|| .      |  |||.||| |.||. | .....| .|.|....
yqltdWPdhGvpqfa..tsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerl..kkEevvdvfevlkqlRskrmkmvqtldqYvflhda
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 5-204 2.1e-45 149.9 In-house 47-237 (250) alignment 
Range on Protein: 5-204
Range on HMM: 47-237/250.0
DHKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEAdYPFYWPTTEsgTGKYGSMSVTTKTITTKPDYTITALILTNNTTAppSTREISH
 ..... .||||.|. .|. |||.||.|  || |||... . ...  |. |||. .  . |||.. |. .   .. |||.. |.|.... |  . | . .
gyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek..aekyGdvtvsllskeefadytkrklklskakka..derivrq

YQFTSWKEKTTPNVALFVgfVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGIISSLPHYNFIYQV
..|..| .|. |.||  |  .   ..| .. .| ..|||||.|| | | .| |.|.|  .   ...|  |||.|.| |.||. | . . ||  | |.|..
lhfvvWPdkgvPevatav..LellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkek..vvdvfkvikvlrkdrphavesleqyvfvyei
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 5-204 1.3e-44 147.6 In-house 86-278 (319) alignment 
Range on Protein: 5-204
Range on HMM: 86-278/319.0
DHKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTEsgTGKYGSMSVTTKTITTKPDYTITALILtNNTTAPPSTREISH
 .. ....|||| |. .|. |||.|||| .|  .||..... . .  .  |||...    .|| . || .    . || |  | | |. ..   |||..|
gyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtleeeeeledyiirklkl.nkkssevetRevkh

YQFTSWKEKTTPNVALFVgfVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHeeSKTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQV
.|.|.| ..  |. |. .  .   ... |  |.... |..||||.| | || |..||. .     .. .|.|.|....|||  |  ...    |.|||..
fqyteWpdhdvPekatsl..ldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlerv..keegvlDvfstvsrlRtqRnimvqrpeqYkfiyea
subfamily_Ptp69D_pd Subfamily Ptp69D 5-203 3.5e-42 139.6 In-house 86-280 (307) alignment 
Range on Protein: 5-203
Range on HMM: 86-280/307.0
DHKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTesGTGKYGSMSVTTKTITTKPDYTITALILTNNTTA---PPSTRE
 .| ....|| | |. .|. |||.|..|  .  |||. . .  .... . |||     . .||.. |..    ...||.| .| ....       . .|.
gykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrk

ISHYQFTSWKEKTTPNVALfvGFVVASREVSKKYEQEkDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGIISSLPHYNFI
.  |..|.||. . |.||   | .   ..| . |...  .|..|||| | | .|.|||||. .   .. .   ||.||. | ||. |  .. ||  | |.
vvqyhytgWkDskvPevar..gllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaed..kvdifetvkdLrsqRnllvqsleqYvfl

YQ
|.
yr
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 5-204 3e-36 119.9 In-house 81-273 (287) alignment 
Range on Protein: 5-204
Range on HMM: 81-273/287.0
DHKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESgtGKYGSMSVTTKTITTKPDYTITALILTNNTTAPpSTREISH
 .| ....|... || .|. .||.....     |||. ... |.|     |||...|    .|  ...    ... .|..  | ..|.. |  .....  
gykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkag.dkqqvkq

YQFTSWKEKTtpNVALFVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEesKTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQV
||.|.|...   .|. .   ..   |  |.  .. .....|||||. | ...|.| .....  .  .  |.|.|.| |. |. . | .    .|.||...
yqitnWdstg..kvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkck..teGviDvfqvlksqriqkpgsvqtveqykfindi
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 5-202 1.9e-15 51.7 In-house 77-264 (288) alignment 
Range on Protein: 5-202
Range on HMM: 77-264/288.0
DHKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTITTKPDYTITALILTNNTTAPpSTREISH
 .| .|| | .| |.. |.  .|.|. |..  .|||...           |.|.    . ..| .   .|   .  | ...  .| .. .    .  . .
sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskege.ekvivki

YQFTSWKEKTTPNValFVGFVVASREVskkyeQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTsvVDLFEVAKRLRQARCGIISSLPHYNFIY
  .  |.... |.   .. ..     .     .. . |..||.| | | || ..   | ..|   .    . . .. ..||. |   | .   | ...
lhlleWdddgvPen..ylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrlddf..lgirsllaklreerfkaiqtemqylyvh
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 6-204 2.2e-145 475.7 In-house 1-199 (199) alignment 
Range on Protein: 6-204
Range on HMM: 1-199/199.0
HKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTITTKPDYTITALILTNNTTAPPSTREISHY
|||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||
hkgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishy

QFTSWKEKTTPNVALFVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQV
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
0040438 (Phosphotyrosine protein) phosphatases II 6-204 8.2e-53 175.1 In-house 65-271 (317) alignment 
Range on Protein: 6-204
Range on HMM: 65-271/317.0
HKG-----------------QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTteSGTGKYGSMSVTTKTITTKPDYTITALI
 .|                 .|..||||.|. .|..|||.|||| |...|||...   ..   .  |||.   .| .|| ..||.. .......|.. | 
lggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtle

LTNNttAPPSTREISHYQFTSWKEKTTP-NVALFVGFVVASREVSKkyeqEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQA
....    . .|.. |...|.| . ..| .  |.. |. | ||. .    ... ||.||||.| | ||.|.|... ..  |. .   ||..|. |.||..
vedl..gdsesrtvthfhytgWpdhgvppspdllldfleavreale....dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg..gvdveeavkelreq

RCGIISSLPHYNFIYQV
|.|.. .. .| |.|..
Rpgavqtpeqyrflyda
Y_phosphatase Protein-tyrosine phosphatase 6-204 1.7e-52 173.6 Pfam-A 38-232 (235) alignment 
Range on Protein: 6-204
Range on HMM: 38-232/235.0
HKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTK-TIT-TKPDYTITALILTNNTTAPpSTREIS
.| ....||||.|. .|..|||.|||.  .  |||.........  .. |||..|... .||...|..|  ..  . .||.. | |.....    .||..
ykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkees.ekrevk

HYQFTSWKEKTTP-NVALFVGFVVASREVSkkyeQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTsvVDLFEVAKRLRQARCGIISSLPHYNFIY
....|.|.....| ..  .. .. . .. .    ..|..||.||||.| | ||.|||||| ... |. ..  ||.... |.||. |.|...||  | |.|
qlhytnWpdhgvpespkslldlirkveksk....eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee..vdvlqivkelRkqRpgmvqsleqYifly

QV
..
ka
Y_phosphatase Protein-tyrosine phosphatase 6-204 1.7e-52 173.6 In-house 38-232 (235) alignment 
Range on Protein: 6-204
Range on HMM: 38-232/235.0
HKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTK-TIT-TKPDYTITALILTNNTTAPpSTREIS
.| ....||||.|. .|..|||.|||.  .  |||.........  .. |||..|... .||...|..|  ..  . .||.. | |.....    .||..
ykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkees.ekrevk

HYQFTSWKEKTTP-NVALFVGFVVASREVSkkyeQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTsvVDLFEVAKRLRQARCGIISSLPHYNFIY
....|.|.....| ..  .. .. . .. .    ..|..||.||||.| | ||.|||||| ... |. ..  ||.... |.||. |.|...||  | |.|
qlhytnWpdhgvpespkslldlirkveksk....eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee..vdvlqivkelRkqRpgmvqsleqYifly

QV
..
ka
0039614 (Phosphotyrosine protein) phosphatases II 6-204 5.4e-51 169.2 In-house 78-284 (297) alignment 
Range on Protein: 6-204
Range on HMM: 78-284/297.0
HKG-------------------QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEaDYPFYWPTTESgtgKYGSMSVTTKTITTKPDYTITA
 .|                   .|..||||.|. ||..|||.|||| |. .|||...   ..   .. |||....   .|| ..||.........||.. 
edgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrt

LILTNnttaPPSTREISHYQFTSWKEKTTP-NVALFVGFVVASREVSKKYeqEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESktSVVDLFEVAKRLR
| .||       .|.. |.|.|.| . ..| ...|.  |. . ||. ...  .|. ||.||||.| | ||.|.|... ..  |.     ||..|. |.||
levtn....ngesrtvthfqytgwpdhgvppslellleflelvrealael..pkggpvlVHCsaGvgRtGtfiaaylmleqleke..ggvdvleavkelr

QARCGIISSLPHYNFIYQV
..|.|.. .. .| |.|..
eqRpgavqtpsqyrflyda
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 6-204 1.4e-43 144.2 In-house 85-275 (318) alignment 
Range on Protein: 6-204
Range on HMM: 85-275/318.0
HKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTteSGTGKYGSMSVTTKTITTKPDYTITALILTNntTAPPSTREISHY
.. .. |||.| |. ||. |||.|||| .|  |||. . . .  |    |||   .|. .||.. |. |  ..  ||..  . .|.  |   ..|..  |
yrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPs..kgsrsygklvvelkeevelsdyvlrefkvtr..teeeesrqvrqy

QFTSWKEKTTPNVAlfVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGIISSLPHYNFIYQV
..||| .. .|. .  ....   |.|||  ....  |..|||| | | ||||.|.|| ..  .. .  .||.|.. |.||. |  ..     |.|||.|
hytsWpdegvpesg..aslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaea..lvDvfqtvkqlreqrnlmvqtedqyefiydv
subfamily_PTPRK_pd Subfamily PTPRK 6-204 1.3e-42 140.7 In-house 82-272 (314) alignment 
Range on Protein: 6-204
Range on HMM: 82-272/314.0
HKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTesGTGkYGSMSVTTKTITTKPDYTITALILTNNTTAPPSTREISHY
.|  . .|.||.|..||..|||..|.. ..  |||... ...       |||    ..  || . |.    ... .. .  . ... . .   .||. ..
ykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed..tev.ygdikvelvetellaelvvrifrveklargqeeirevrqf

QFTSWKEKTTPNVAlfVGFVVASREVSKKYEQeKDAPVIVHCSDGQGFTGVFVALDIGVRSHEesKTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQV
||..| .  .|. |   |..   |.| |. |. .. ...|||| | | ||.|.|.|| .   |  . .|||.|...| ||. .  ..     |.|||.|
qflgWpdhdvPvsa..tgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmie..regvvdvfnavktlrsrkvnmveteeqykfiydv
subfamily_PTPRA_pd Subfamily PTPRA 6-204 3e-41 136.4 In-house 97-290 (330) alignment 
Range on Protein: 6-204
Range on HMM: 97-290/330.0
HKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTteSGTGKYGSMSVTTKTITTKPDYTITALILTN--NTTAPPSTREIS
.| . ..||.| | .||. |||.|.||  |  |||. . .. ||     |||.   |.  || . |. .  |   |||.  .....  ..|   ..| ..
ykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd..eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvr

HYQFTSWKEKTTPNVAlfVGFVVASREVSKKYEQEKDaPVIVHCSDGQGFTGVFVALDIGVRS-HEEsktSVVDLFEVAKRLRQARCGIISSLPHYNFIY
 . |||| .   |  .  .| .   ..| |. .|. . |..|||| | | || |..||  .   . |    .||.||. ||||. |. .. ..  |.|||
qfhftswPdvGvPfep..iGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkae...rkvdvfefvkrlrlqrpqmvqtdeqyefiy

QV
.|
kv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 6-204 7.1e-40 131.9 In-house 80-271 (281) alignment 
Range on Protein: 6-204
Range on HMM: 80-271/281.0
HKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESgTGKYGSMSVTTKTITTKPDYTITALILtNNTTAppSTREISHY
 ||...||||| |. .....|||||||.    ||||  . ..       |||  .| . ||| . |.... ..|. |    . | .....   |||... 
ykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddns.elkygdvtvkstaeeekatyierkfkl.eresg..etreveql

QFTSWKEKTTPNVAlfVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEeSKTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQV
..|.| ..  |. .    ..   .|| |  |....||...||| | | ||...|||  |.. | .... .|. .| . ||..|  .. ..  |.|.|..
aytaWPdhGvPatt..kellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkave.aeleeldvkavvaelrkernlmvqtvvqyefvyka
subfamily_PTPN9_pd Subfamily PTPN9 6-203 2.4e-37 123.6 In-house 81-284 (297) alignment 
Range on Protein: 6-203
Range on HMM: 81-284/297.0
HKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTITTKPDYTITALILTNNTTAppSTREISHY
.| .. .|||| |...|. |||.||||     |||.     ..      |||..|  . ..|..||..  . .. ||... | ..| .|    .|...|.
ykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkte..esrkvthf

QFTSWKEKTTPNVAL-FVGFVVASRE--------VSKK-YEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEEskTSVVDLFEVAKRLRQARCGIISSL
||.|| .  .|. |  .. .. . ||        ....   . .. |..|||| | | || |..||| .   ||  ...||..|. |.||. |   |   
qflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrlee..vgtvdvvetvkllrtqrafsiqtp

PHYNFIYQ
  |.| |.
eqyefcyl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 6-203 4.9e-23 76.5 In-house 68-253 (267) alignment 
Range on Protein: 6-203
Range on HMM: 68-253/267.0
HKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNddqKNKEADYPFYWPTTESGTGKYGSMSVTTKTITTKPDYTITALILTNNTTappSTREISHY
.| .. .|.|| |.. |..||.... . .   ||..    |  . . . .||     . ||  ..|       . || | .| |  .     |..... |
yktknafivtqdplkntitdfltvihdqkvpvivllt...kvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkne...sahnvtly

QFTSWKEKTTPNVALFVGFVVasreVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEesKTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQ
 .  |. .|  .  |   | .    ..|.  .. . |..|.|||| | .| |. .|  ..     . .|.|.|.  ...|. | |.. .. .| .|..
yykkwnintnnkpylkplfgi....laknqlengnrPlvvacsdGvGrsGtflvidsqlerak..tegvsdifdflrkirsqriglvdtkeryiyihe
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 6-117 2.2e-16 54.6 In-house 72-182 (297) alignment 
Range on Protein: 6-117
Range on HMM: 72-182/297.0
HKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTITtKPDYTitALILTNNTTA-PPSTREISH
 . . .|| .| |...|. |||..|.| . . ||||   |..       ||| .. .  | |.. |   . |   ..    .|||. .      .| . |
eeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsst.sdefd..rviltelqliyrsesrvvrh

YQFTSWKEKTTP-N
 || || ..  | .
vqflswpdhGvpsd
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 6-203 2.3e-08 28.0 In-house 79-273 (303) alignment 
Range on Protein: 6-203
Range on HMM: 79-273/303.0
HKGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESgTGKYGSMSVT---TKTITTKPDYTITALILTNNTTAppSTREI
 . ... | || |.  | ||||||. |     ....  | . ..    . .|  .    |.   |.     | .     ...  | ..| .    |   .
ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd.flkfeersirvgefkrvelgdgwvlkvlsvsngdyk..sflhv

SHYQftSWKEKTTPNV--ALFVGFVVASREVSKKYEQEKdaPVIVHCSDGQGFTGVFVALDIGVRSHEESKtSVVDLFEVAKRLRQARCGIISSLPHYNF
 ||.  .|  .. |.   . ||  .   . | .|| . .  | .     | | .| |  ..    |  . . . .||  . . .|. |   .  |  . .
hhyk..awphnsipsdgspkfvkqiwqlqsvlrkysdst..ptvymslsgcgragtfalfetahlslhseq.asldlvkclenvrngrlhavqnlsqfsv

IYQ
.| 
vyt
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 7-204 2.1e-144 472.5 In-house 1-198 (198) alignment 
Range on Protein: 7-204
Range on HMM: 1-198/198.0
KGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTITTKPDYTITALILTNNTTAPPSTREISHYQ
||||||||||||.|||.|||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||
kgqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

FTSWKEKTTPNVALFVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQV
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
0050432 (Phosphotyrosine protein) phosphatases II 7-204 7.2e-56 185.1 In-house 105-294 (308) alignment 
Range on Protein: 7-204
Range on HMM: 105-294/308.0
KGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTES-GTGKYGSMSVTTKTITTKPDYTITALILTNNTTAppSTREISHY
| .|..||||.|. .|..|||.|||| .. .|||... . |.   .. |||...  |. .|| ..||.. .....|||.. |.|||. .    .|.. |.
klprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg..esrtvthf

QFTSWKEKTTPN-VALFVGFVVASREVSkkyeqeKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESktSVVDLFEVAKRLRQARCGIISSLPHYNFIYQV
..|.|..  .|. .. .. |. . |..       .. |..||||.| | ||.|.|||. ..  |.     ||.||. |.||. |.| . .. .| |.|..
hytnWpdhgvPpspeilldflelvrksl......pggpivVHCsaGvGRtGtfialdllleqleke..ggvdvfeavkklReqRpgmvqtpeqylflyra
0046845 (Phosphotyrosine protein) phosphatases II 7-204 2e-55 183.5 In-house 74-269 (284) alignment 
Range on Protein: 7-204
Range on HMM: 74-269/284.0
KGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTeSGTGKYGSMSVTTKTITTKPDYTITALILTNNtTAPPSTREISHYQ
. ....||||.|. .|..|||.|||| .. .|||...   |.   ...|||.. ... .|| ..||.. ...|.|||.. | |||.   .  .|.. |..
yikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnl.gytgesrtvthfh

FTSWKEKTTP-NVALFVGFVVASREVSKKyeQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESK-TSVVDLFEVAKRLRQARCGIISSLPHYNFIYQV
.||| .  .| ... .. |. . ||. ..   ... |..||||.| | ||.|.|||.  .  |. . ...||..|. ||||. |.| . .| .| |.|..
ytswpdhgvppspedlleflrlvrellen..lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyea
0051299 (Phosphotyrosine protein) phosphatases II 7-204 7.9e-55 181.7 In-house 89-281 (288) alignment 
Range on Protein: 7-204
Range on HMM: 89-281/288.0
KGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTteSGTGKYGSMSVTTKTITTKPDYTITALILTNN--TTAPPSTREISH
. .|..||||.|. .|..|||.|||| .. .|||... . ..  ... |||.  .|. .|| ..||.. .....|||.. |..||.  .. .  .|.. |
nlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvth

YQFTSWKEKTTPN-VALFVGFVVASREVSKkyeqEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESktSVVDLFEVAKRLRQARCGIISSLPHYNFIYQ
...|.| .  .|. . |.. |. . |.. .     .. ||.||||.| | ||.|.|||. ..  |.    .||..|. ||||. |.|.. .. .| |.|.
fhytnwpdhgvpdspellldflrlvrkala....sgggpvvVHCsaGvgRtgtfialdllleqleke..ggvdvleavkrlreqRpgmvqtpeqyrfvye

V
.
a
0036941 (Phosphotyrosine protein) phosphatases II 7-204 1e-54 181.3 In-house 75-272 (297) alignment 
Range on Protein: 7-204
Range on HMM: 75-272/297.0
KGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTITT--KPDYTITALILTNNTTAppSTREISH
. .|..||||.|. .|..|||.|||| .. .|||....  .    .. |||..| .. .|| ..||......  ..|||.. | .|.. .    .|.. |
dlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng..esrtvth

YQFTSWKEKTTPN-VALFVGFVVASREVSKKYeqEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEES-KTSVVDLFEVAKRLRQARCGIISSLPHYNFIY
...|.| .  .|. .| .. |. . |.| |..   .. ||.||||.| | .|.|.|.|. ..  |.. |.  ||..|. | ||. |.|.. .| .| |.|
fhytgwpdhgvpespaslldfielvrkvlkll..psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfly

QV
..
ea
0047943 (Phosphotyrosine protein) phosphatases II 7-204 1.1e-53 177.8 In-house 74-267 (273) alignment 
Range on Protein: 7-204
Range on HMM: 74-267/273.0
KGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESG-TGKYGSMSVTTKTITTKPDYTITALILTNNTTAPpsTREISHY
. .|..||||.|. .|..|||.|||| .. .|||..... ..  ... |||... . . .|| ..||.. ..||.|||.. |.|||. |    .|.. |.
nlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge..srtvthf

QFTSWKEKTTP-NVALFVGFVVASREVSKKYEQEkdAPVIVHCSDGQGFTGVFVALDIGVRSHEESktSVVDLFEVAKRLRQARCGIISSLPHYNFIYQV
..|.| .  .| ... .. |. . |.. ... ..   ||.||||.| | ||.|.|||. ..  |.     ||..|. |.||. |.|.. .. .| |.|..
hytgwpdhgvppslesllefielvrkalealpsn..gpvvVHCsaGvgRtgtfialdllldqleke..ggvdvleavkllrsqRpgmvqtpeqyrflyea
DSPc_SM00195 7-204 2.3e-50 166.7 In-house 66-257 (263) alignment 
Range on Protein: 7-204
Range on HMM: 66-257/263.0
KGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTITTKP-DYTITALILTNNTTapPSTREISHY
. ...|||||.|. .|..|||.||||...  |||......|..     ||| .. |. ..|..||...  ..|. ..... | ||....    ||.. .|
nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqy

QFTSWKEKTTP-NVALFVGFVVASREVSKKYeqekDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTsvVDLFEVAKRLRQARCGIISSLPHYNFIYQV
|...|... .| .   .. .. | .. ...     ..|..||||.| | ||.||..|| ... || |.  ||.||. |.||. |.|....| .| |||..
qyknWpdhgvpdstksvlellravkksksts....sgpivVhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtleqYlfiyea
PTPc_SM00194 7-204 2.3e-50 166.7 In-house 66-257 (263) alignment 
Range on Protein: 7-204
Range on HMM: 66-257/263.0
KGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTITTKP-DYTITALILTNNTTapPSTREISHY
. ...|||||.|. .|..|||.||||...  |||......|..     ||| .. |. ..|..||...  ..|. ..... | ||....    ||.. .|
nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqy

QFTSWKEKTTP-NVALFVGFVVASREVSKKYeqekDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTsvVDLFEVAKRLRQARCGIISSLPHYNFIYQV
|...|... .| .   .. .. | .. ...     ..|..||||.| | ||.||..|| ... || |.  ||.||. |.||. |.|....| .| |||..
qyknWpdhgvpdstksvlellravkksksts....sgpivVhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtleqYlfiyea
subfamily_PTPRG_pd Subfamily PTPRG 7-204 2.7e-42 139.7 In-house 88-282 (563) alignment 
Range on Protein: 7-204
Range on HMM: 88-282/563.0
KGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTteSGTGKYGSMSVTTKTITTKPDYTITALILTN----NTTAPPSTREI
. .. .||||.|...|. |||.|.||  .  |||. . ....  . . |||.   .. .||...|| ..  ..  ||.  |.. |    ..    . ...
qkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklv

SHYQFTSWKEKTTPNVALFVGFVVASREVSKKyeqEKDAPVIVHCSDGQGFTGVFVALDIGVRshEESKTSVVDLFEVAKRLRQARCGIISSLPHYNFIY
 .|..|.| ....|. .|.|   |  .. ..|   ..  |..|||| | | ||....||  ..  .  . ..|..|...|..|  |  .. .   | |..
rqyhytkWPdhgvPehslpvLifvkkssaank...aeaGPivvHcsaGvgrtGtyivldtllk..qiqqenavnvfgflkhiraqRnflvqteEqYiflh

QV
..
da
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 7-204 4e-37 122.8 In-house 89-274 (315) alignment 
Range on Protein: 7-204
Range on HMM: 89-274/315.0
KGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTesgTGKYGSMSVTTKTITTKPDYTITALiltnNTTAPPSTREISHYQ
. .|||||.| |  ... |||..|.|   |.|||...  ....     |||        || ..|| |    . .||. .|     ..     ||.  ..
nkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtl....svvfgdnirevvqlh

FTSWKEKTTPNVAlfVGFVVASREVsKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGIISSLPHYNFIYQV
.||| .   |. .  . ..   | | |...... ....||||.|.| || |..||  .   |  .  ..|.... ...|| | ......  |.|||..
ytswpdmgvpkyt..iplmnlirtv.kqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaen..aidvynfitgvrqnrikmvqvaeqyqfiyda
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 7-204 2.5e-34 113.4 In-house 82-288 (301) alignment 
Range on Protein: 7-204
Range on HMM: 82-288/301.0
KGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTITTKPDYTITALILT-----N--------NT
. ....||.| ||..|..|||...|.    .|||| . ......    |||..|  . ..| ..|| .  .. ||..|  | ..     |        ..
sekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkv

TAPPSTREISHYQFTSWKEKTT---PNVALFVgfvVasREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVrshEESK-TSVVDLFEVAKRLRQARC
..  |....  .| |.| .      |.  | |   .   .| ..  .   .||.|||||. . .||.....||.   |  |   |||.|.| |..|. . 
ksdksswdvlqlqvtdWpqdGvvreprtvLqv...i..ddvihrqqkigggpvvVHCSdtVsrsGvYcsvsigl...EQckaegVVdvfqvtkavrrskp

GIISSLPHYNFIYQV
| .  |  | .||.|
gaVtTLeqytsiydv
subfamily_PTPN1_pd Subfamily PTPN1 7-203 7.5e-33 108.5 In-house 68-265 (290) alignment 
Range on Protein: 7-203
Range on HMM: 68-265/290.0
KGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTES-GTGKYG--SMSVTTKTITTKPDYTITALILTNNTTAppSTREIS
. .|.|| || |. .|.. |||||||  |  .||.|    ...     |||. |.  . ..   ...|.  .  .|  ||.  | |.| .|    ||||.
eakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktq..etreil

HYQFTSWKEKTTPNV-ALFVGFVVASREVSKKyeQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESK-TSVVDLFEVAKRLRQARCGIISSLPHYNFI
|. .|.| . . |.  | |. |.   ||      ...  |...||| | | .| |. .|  .   |... .| ||. .|   ||. | |.|      .| 
hfhyttwpdfgvpespaaflkflfkvresGsl..ssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfs

YQ
|.
yl
0049772 (Phosphotyrosine protein) phosphatases II 7-203 3.5e-22 75.0 In-house 81-274 (314) alignment 
Range on Protein: 7-203
Range on HMM: 81-274/314.0
KGQRRYIATQHPMRETMADF----------WQMV--WETGSGHIVM---------------------VNDDQKNKeadyPFY--------Wpttesgtgk
.| ...||||.|. .|. ||          |.||  ..  .  |||                      ..   |     ...                  
dgflkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng....neptaadlellk.........

ygsmsvttktittkpdY-------TitaliltnnttappsTREISHYQFTSWKEKTTPNVALFVGFVVASREVskkyeqEKDAPVIVHCSDGQGFTGVFV
                                        .|.. .|  . .   ..|  . |  |. . .|.      .|. ||.|||..| | ||.||
................eelydpelf...............erlgikylripvpDgsaplledfdeflefieea......dkggpvlvHCkaGkgRtgtfv

ALDIGVRSHEesktsvVDLFEVAKRLRQARC-----GIISSLPHYNFIYQ
.... .. .       |.| |. ...|..|      | | .| .| ||..
vaaylmkllg......vsleealedvrlkRpinpnpgfieqleqyefile
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 7-203 5.5e-18 59.9 In-house 72-264 (285) alignment 
Range on Protein: 7-203
Range on HMM: 72-264/285.0
KGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTITTK--PDYTITALILTNNTTAPPSTREISH
| |  ||.|| |. ||..|||.|...    ...|.    .       .|.|       |.|   .|      .      . || ..|   |      . |
kdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnh

YQFTSWKEKTTPNVALFVgfVVASREVsKKYeQEKDAPVIVHCSDGQGFTGVFVALDIG-VRSHEESKtsvVDLFEVAKRLRQARCGIISSLPHYNFIYQ
 |   | .. .|. |  .  .   . | ||  . |. |. |||| | | |  || .|   .|  |. .   ...... . .|  |   . |  .. |.| 
vqvpwwpdqlapedarpm..ielykwv.kkv.npkekpicvhcsagvgrtatfvgidyatirimenpn...iemldivremramrfqavqshmqflflyv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 7-58 4.6e-08 26.8 In-house 104-155 (349) alignment 
Range on Protein: 7-58
Range on HMM: 104-155/349.0
KGQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPT
. ...||||| |.  |. ||....   |   .. .|||...    .  ||  
svekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe
0045450 (Phosphotyrosine protein) phosphatases II 8-204 6.9e-51 169.2 In-house 105-299 (307) alignment 
Range on Protein: 8-204
Range on HMM: 105-299/307.0
GQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTeSGTGKYGSMSVTTKTITTKPDYTITALILTNNtTAPPSTREISHYQF
 .|..||||.|. ||..|||.|.|| |...|||....  ..   .. |||.. ...  || . ||.. ......||.. | .|..      .|.. |...
lkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvthfhy

TSWKEKTTP-NVALFVGFVVASREVSKKYeqEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTSV-VDLFEVAKRLRQARCGIISSLPHYNFIYQV
|.| . ..| ... .. |. . |.. ...   |. ||.||||.| | ||.|.|...  | .|. .|   |||.|. |.||. |.|.. .. .| |.|..
tgwpdhgvppsfeelldfieevrkaleel..pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea
0043336 (Phosphotyrosine protein) phosphatases II 8-204 4.1e-50 166.2 In-house 86-272 (278) alignment 
Range on Protein: 8-204
Range on HMM: 86-272/278.0
GQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPtteSGTGKYGSMSVTTKTITTKPDYTITALILTNNTTAPPstREISHYQF
 .|..||||.|. ||..|||.|||| |. .|||....  ..   .  |||   .|. .|| ..||.. .....|||.. | .||. . ..  |.. ||..
vprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdges..rtvthyhy

TSWKEKTTP-NVALFVGFVVASREVSKkyeqEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGIISSLPHYNFIYQV
..| . ..| ...|.. |. | ||. .     .. ||.||||.| | ||.|.||.. ..  |  .   |||.|. |.||. |.|.. .. .| |.|..
lgwpdhgvpeslsllldflkavreale....dsngpvlVHCsaGvgRTGtfialyllleqlekeg..gvdleeavkelreqRpgavqtpsqyrflyea
0040439 (Phosphotyrosine protein) phosphatases II 8-204 5e-48 159.2 In-house 52-241 (249) alignment 
Range on Protein: 8-204
Range on HMM: 52-241/249.0
GQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTteSGTGKYGSMSVTTKTITTKPDYTITALILTNNttAPPSTREISHYQF
 .||.||||.|. ||..|||.|.|| |...|||..... ..  ..  |||.  .|. .|| ..||.. ...|.|||.. | |||.    ...|.. |.|.
ikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggsleygdftvtllsvevkddytvrtleltnl..ydgesrtvlhiqy

TSWKEKTTP-NVALFVGFVVASREVSKKYeqEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEesKTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQV
|.| .  .| ... .. |. | |.. ...  .|. ||.||||.| | ||.|.|... ..  |  |.  |||.|. | ||..|.|.. .. .| |.|..
tdwpdhgvppsfedlldfieavrkaleel..pkggpvlVHCsaGvgRtGtfiaaylmleqle..kelgvdleeavkllrsqRpgavqnpeqyrflyea
0042113 (Phosphotyrosine protein) phosphatases II 8-204 1.2e-46 154.4 In-house 50-238 (245) alignment 
Range on Protein: 8-204
Range on HMM: 50-238/245.0
GQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTteSGTGKYGSMSVTTKTITTKPDYTITALILTNntTAPPSTREISHYQF
  ...||||.|..|| .|||.|.|| |. .|||....  ..  ... |||.  ... .|| ..||........|||.. | .||  .  . .||. ||..
itpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..gesltygdftvtllseehlddytvrtlevtn..lgddesrevihyhy

TSWKEKTTPN-VALFVGFVVASREVSKKyeqEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEesKTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQV
..| . ..|. ..|.. |. . |.. ..    .. ||.||||.| | ||.|.|... ..  |  |.  |.|.|. |.||. |.|.. .. .| |.|..
lpwpdhgvpdllellldflefvrkalae...dsngpvlVHCsaGvgRtGtfiaaylmleqle..kelgvsleeavkelrsqRpgavqtpsqyrflyea
subfamily_PTPN6_pd Subfamily PTPN6 8-204 3.8e-40 132.8 In-house 96-292 (306) alignment 
Range on Protein: 8-204
Range on HMM: 96-292/306.0
GQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGkYGSMSVTTKTITTKPDYTITALILTNNtTAPPSTREISHYQF
 ...|||||  ...|..|||.|||.  |  |||.  .    .     |||..|. .  ||..|||. . ... ||..  | .... .   ..||. .|.|
sdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskk.kkkkeerevfqyhf

TSWKEKTTPNVAL-FVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTSV-VDLFEVAKRLRQARCGIISSLPHYNFIYQV
.|| .. .|.    .. |.   .. ... |...  |..||||.| | || |. .|| ..  |.... . .|. .. | .|. | |..     |.|.|..
ksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvyka
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 8-203 1e-36 121.3 In-house 62-258 (270) alignment 
Range on Protein: 8-203
Range on HMM: 62-258/270.0
GQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTIT--TKPDYTITALILTNNTtappSTREISHY
 ...|||.. |.  |. .||.|.||. .  |||. . . .       |||.    . |.  . ... ...   .  | .| | |...     ..|.. |.
ekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekg....eerrlvHf

QFTSWKEKTTPNVAL----FVGFVVASREVSKKYEQEKD-APVIVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGIISSLPHYNF
....| ... |. .         .   |.| .  .. ..  |..||||.| | ||...||||.||  ||.|   ||. .. ..||. |. ...   .|.|
wyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetk..kvdvlaiieelRkdRmalvqhpeqyef

IYQ
.|.
lyk
subfamily_PTPN13_pd Subfamily PTPN13 8-204 1.8e-34 114.3 In-house 75-264 (273) alignment 
Range on Protein: 8-204
Range on HMM: 75-264/273.0
GQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKY-GSMSVTTKTITTKPDYTITALILTNNTTAppSTREISHYQ
 . .|||.| |. ||..||||||||  .  |.||  .. ...     ||| ... . |  . . |.   .. . .... || .... ..   .||..| .
deyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesg..esrevahln

FTSWKEKTTPNVAL-FVGFVVASREVSKkyeqeKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGIISSLPHYNFIYQV
|..| .  .|. |. .. ||   |.. .     . .|..|||| | | .|.....|. .   |  |   .|. |. ..||. | |.. .   | |.|..
fvkwPdhgvPssaaellqfvaevrrlqt.....dagPivvhcsaGiGrsGtlitidvvlglierdk..efdvkeivrklreqrqgvvqtkdqyifvyka
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 8-203 2e-33 110.6 In-house 42-233 (237) alignment 
Range on Protein: 8-203
Range on HMM: 42-233/237.0
G-QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTgKYGSMSVTTKTITTKPDYTITALILTNNTTAPpSTREISHYQ
|  ..|||.| |.  .  |||||||.     |||.    ...|     ||| |.  .  || ..|. |      |||. .|.|....|     | |  ||
gtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa.aygvltvslkkkeefsdytvrslllskrltlk.evrlihqyq

FTSWKEKTTPNVALFVgFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGIISSLPHYNFIYQ
|||| ..  |. .  . .    . . .     . .| |.||| | | ||.|. .|  .|  .| |  |||...  . . . |  || .  .| ||.|
ftswpdrgvpqqtaal.lrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekk..vvdiynyvysieedrpyiiqtkdqyvfihq
0049260 (Phosphotyrosine protein) phosphatases II 8-203 5.7e-29 96.2 In-house 7-144 (152) alignment 
Range on Protein: 8-203
Range on HMM: 7-144/152.0
GQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWpttesgtgkygsmsvttktittkpdytitaliltnnttappstreisHYQF
 ....||||.|...|.||||.|..| | ..|||..... ...   ..|.                                               .|..
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...............................................qylh

TSWKEKTTPNVALFVGFVVASREVSkkyEQEKDAPVIVHCSDGQGFTGVFVALDIGVrsheesktSVVDLFEVAKRLRQARCGIISSLPHYNFIYQ
. |   ..|. . .. |..   |      ..|. ||.|||| | | ||..||...            |.|.|. ...|..| |.. .  .. |.|.
lpwpDhgvpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml........lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 8-203 2.4e-26 87.2 In-house 78-271 (287) alignment 
Range on Protein: 8-203
Range on HMM: 78-271/287.0
GQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESgTGKYGSMSVTTKTIT-TKPDYTITALILTNNTTAppSTREISHYQ
 . ..||.| |.  |. |||..|.|| |  ....  . ..       |||  |    . |  ||.    .  .|.|.. || | .  |    .| .  ..
ddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerev.PmrvGGysvvlldydikePeygvralrlidletr..earvvkqld

FTSWKEKTTPNV-ALFVGFVVAS-REVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEEskTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQ
. || .|. .     .. ||.   . .  . . ..  |..||.. | | .|...|. . |.  |.  .  ||   |  |||. | ... .   . ..|.
llswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrled..lGrvdvaavvirlreyraalvqavvqlrllye
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 8-203 2.4e-24 80.5 In-house 86-230 (392) alignment 
Range on Protein: 8-203
Range on HMM: 86-230/392.0
GQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKeadypfywpttesgtgkygsmsvttktittkpdytitaliltnnttAPPSTREISHYQF
 .. |||.| |   .. |||.||..     |.||.. ..                                                   ..| .. ..|
nekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..............................................kgddartvaqfhf

TSWKEKTTPNVALfvGFVVASREVSKKYEQEKdAPVIVHCSDGQGFTGVFVALDIGVrSHEeSKTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQ
| | .|  |. .    ..   .||. .. |    |.|.||| | | ||| ...|  | .|   || .||.|..   .|. |  .. .  .| ||| 
tewPdkdvpkhts..sllkfikevkadfGqyt.hpliihcsagvgrtgvvisidsvv.aha.kktrmvdvfnfvtnirrkrpymvqtkeqyafiyg
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 8-58 2.3e-06 21.4 In-house 83-132 (347) alignment 
Range on Protein: 8-58
Range on HMM: 83-132/347.0
GQRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNkEADYPFYWPT
 .. || ||.|. .|. |||.||  |    .| . . .|. ||   |  .|
askeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikd.eaieefanat
0045098 (Phosphotyrosine protein) phosphatases II 9-204 2.5e-49 163.5 In-house 63-267 (278) alignment 
Range on Protein: 9-204
Range on HMM: 63-267/278.0
QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTteSGTGKYGSMSVTTKTITTKPDYTITALILTNNTTAPPST--REISHYQ
....||||.|. .|.||||.|.|| |. .|||... . ..   .. |||   .|.  || ..||.. ... .|||.. |..|| |. ...   |.. |..
pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlh

FTSWKEKTTPNVALFVGFVVASREVSKKYE------------QEKDAPVIVHCSDGQGFTGVFVALDIGVRSHeeskTSVVDLFEVAKRLRQARCG-IIS
...| . ..|.  .   |  . ... . ..            .... ||.|||| | | ||..||...  .       ..|||.|. | ||. |.| .. 
ylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell....eggvdlleavkelrsqRpglavq

SLPHYNFIYQV
.| .|.|.|..
nleqyrflyef
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 9-204 2.4e-45 149.8 In-house 72-263 (274) alignment 
Range on Protein: 9-204
Range on HMM: 72-263/274.0
QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESG--TGKYGSMSVTTKTITTKPDYTITALILTNNTTappsTREISHYQ
.. |.||| |. .|.||||.|.... .  |||. . . ..|.    |.|..|.   ...|| ...... |... ||... |.| . .     .|.. || 
skayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler....ersvkhyw

FTSWKEKTTPNVALFVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEEskTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQV
.|.| .. .|. |  .  .|.  | |.. |..| |||.|||| | | ||.|.| .|.||  .|  ..|||....   ||. | |.. .   |..|...
ytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlre..eivvdvlkivcnlrldrGGmvqtseqyelihra
0037934 (Phosphotyrosine protein) phosphatases II 9-204 2.7e-43 143.6 In-house 43-237 (243) alignment 
Range on Protein: 9-204
Range on HMM: 43-237/243.0
QRRYIATQHPMRETMAD----FWQMVWETGSGHIVMVNDDQKNKEADYPFYWPttesGTGKYGSMSVTTKTITTKPDYTITALILTNnTTAPPSTREISH
 .|.||||.|. || .|    ||.|.|| |...|||..... ..  ... |||    |.  || ..||.. .....|||.. | |.| . ... ||.. |
tprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp....gevtygdftvtllseehlddytvrtlllen.ldlddltrlvih

YQFTSWKEKTTPN-VALFVGFVVASREVSKKY----EQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHeesktSvVDLFEVAKRLRQARCG-IISSLPHY
|....| . ..|. .. .. |. . ||. ...       .. ||.|||| | | ||...|...  .       . |||.|. |.||. |.| .. .. .|
yhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll.....g.vdleeavkllreqRpgkavqtpsqy

NFIYQV
 |.|..
rflyea
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 9-203 3.5e-41 136.2 In-house 91-278 (297) alignment 
Range on Protein: 9-203
Range on HMM: 91-278/297.0
QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEaDYPFYWPttESGTGKYGSMSVTTKTITTKPDYTITALILTNNTtaPPSTREISHYQFT
. |.|.|| ||..|.||||.||..     |||.|||.....     ||.  ..|. ..|..||...... .  .    | .|..   . ..| .  |||.
khrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs..dkgvttfGdvsvvllsvsereGfikrelevtkgk..akarrvvkqyqfv

SWKEKTTPNVALFVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEesKTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQ
.| .|. ..      ..    || |...|....|..|||. | | |||....|  |   .  ..  ||.|.. |.||| |  ..    .|.|.|.
eWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeak..rekevdifglvkklrqerpylvqtkeqykfvyv
subfamily_PTPN14_pd Subfamily PTPN14 9-204 6.3e-39 128.7 In-house 92-291 (300) alignment 
Range on Protein: 9-204
Range on HMM: 92-291/300.0
QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTE--SGTGKYGSMSVTTKTITTKPDYTITALILTNNTTAppSTREISHYQ
.| ||..| |.. |. ||||||||.|   |||. .....       |.| .|    | ..|   ||||  .. . .. |.| |    .     |.. | |
ersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpsk..eertvwhlq

FTSWKEKTTPN-VALFVGFVVASREVSKKYEQEK-----DAPVIVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGIISSLPHYNF
.| | ..  |. |  |. ..   . | .| ..|.     . ||.||||.| | ||| .  |. . . |  .  ..|. .| .|||. |  ....|  |.|
ytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehne..eidikkvlarLreqrmllvqtlaqYkf

IYQV
.|.|
vYkv
subfamily_CG7180_pd Subfamily CG7180 9-204 7.4e-38 124.9 In-house 84-285 (296) alignment 
Range on Protein: 9-204
Range on HMM: 84-285/296.0
QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEaDYPFYWPTTEsgTGKYGSMSVTTKTITTKPDYTITALILTNN--------TTAPPSTR
.. || |. |..||. .||..|.. ..  .|.. .    ..  || ||| .     .|| . | . .  . .. .|  . || .        .     ||
kkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetR

EISHYQFTSWKE-KTTPNV-ALFVGFVVASREVSKKY-EQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEesKTSVVDLFEVAKRLRQARCGIISSLPH
 . ..|.| |.  .  | . . .. ..   | . .|  |... .||.|..|||.. .||..|.|. .   |  |.  ||.|| .|.||. | ... .  .
ivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelve..keeevdvFeavktlrrsRpqLvenvee

YNFIYQV
| .||.|
YkyiYdv
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 9-204 8.2e-38 125.0 In-house 86-272 (315) alignment 
Range on Protein: 9-204
Range on HMM: 86-272/315.0
QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTITTKPDYTITALILTNNTTappsTREISHYQFT
.. |||.| | . .. |||.||...    ||||.. |..       |||  .. . ..||..|..  . .  | ..  |.. .  .    .| .. .|||
dkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrksee....srtvtqfqft

SWKEKTTPNVALfvGFVVASREVSKKyEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHeeSKTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQV
 | .| ... .    ..   .||  . ...|. ...|||| | | |||....|  |      .|..||.|.. | ||. |  .. .  .| |||..
ewPdkGvdkqts..sllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqi..krtrsvdvfnfvknlrakrpylvqteeeyafiyda
subfamily_PTPN3_pd Subfamily PTPN3 9-201 6.2e-37 122.0 In-house 83-267 (280) alignment 
Range on Protein: 9-201
Range on HMM: 83-267/280.0
QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTtESGTGKYGSMSVTTKTITTKPDYTITALILTNNTTAppSTREISHYQFT
  |||||| |...|..||||||||  |  |||. .   .       |||. .. . .||..||. .   ..  | .  |.|....|     |.| . |..
vnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketk..eerkilqlqyl

SWKEKTTPNV-ALFVGFVVASREVSkkyeQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTsvVDLFEVAKRLRQARCGIISSLPHYNFI
.| ... |.  | |. ||   |..     . |. ||.|||| | | |||...|.. .   |...   |   .. ...|. |  .. .   |.|.
aWpdhgvPddsadflefvervrklr....sgkeePvvvhCsaGigrtGvlilletalalieaaep..vypldivrtmrdqramlvqtasqykfv
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 9-203 2.2e-35 117.5 In-house 103-285 (319) alignment 
Range on Protein: 9-203
Range on HMM: 103-285/319.0
QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNddqKNKEADypfYWPTTesGTGKYGSMSVTTKTITTKPDYTITALILTNNTTApPSTREISHYQFT
. .|||.| |. .|.||||.|.||  .  ||..    |.| ..   |||    .  |.. . |  ....   .|..  . |....      |.|  . | 
kdkyiaaqGPldntladfWrmiweyncstivllt...kdkcsq...ywplk..ivikeerfkvkvdsveetaeyvvrdielsedgke.kdirkitqfhfl

SWKEKTTPNVALFVGFVVAS-REVSKKYEqeKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGIISSLPHYNFIYQ
 | ..  |. .  .  .|   | . .| .  . |...|||| | | |||...||. .   .| |   ||.... . ||| |  .. .|  | ||| 
GwpdvGvpdypsdlmrlvkkvrhltsken..hranivvhcsaGvGrtGvyivldvlldrmkeek..qvdvynfvrdlrqqrntlvqdlvqykfiys
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 9-203 3e-35 117.1 In-house 67-249 (284) alignment 
Range on Protein: 9-203
Range on HMM: 67-249/284.0
QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNddqKNKEADypfYWPTTesGTGKYGSMSVTTKTITTKPDYTITALILTNNTTApPSTREISHYQFT
. .||||| |. .|.||||.|.||  .  ||..    |.| ..   |||    .  |.. . |  ....   .|..  . |....      |.|  . | 
kdkyiatqGPldntladfWrmiweyncstivllt...kdkcsq...ywplk..ivikeerfkvkvdsveeseeyvvrdielsedgke.kdirkirqfhfl

SWKEKTTPNVALFVGFVVAS-REVSKKYEqeKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESktSVVDLFEVAKRLRQARCGIISSLPHYNFIYQ
 | ..  |. .  .  .|   | ...| .  . |...|||| | | |||...||. .   .|   . ||.... . ||| |  .. .|  | ||| 
gwpdvgvpdypsdlmrlvkkvrhltsken..hranivvhcsagvgrtgvyivldvlldrmkee..kqvdvynfvrdlrqqrntlvqdlvqykfiys
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 9-204 6.3e-35 115.2 In-house 85-271 (515) alignment 
Range on Protein: 9-204
Range on HMM: 85-271/515.0
QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTITTKPDYTITALILTNNTTappsTREISHYQFT
.. |||.| | . .. |||..|..     |.||.. ...       |||   . . |.||..| . .. .  . ..  | .. .      .| .  ..||
dkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd....srtvtqfhft

SWKEKTTPNVAlfVGFVVASREVSKKYEQEKdAPVIVHCSDGQGFTGVFVALDIGVRSHeeSKTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQV
 | .| .|. .    ..   .||  . .| .  |.|.||| | | |||....|  |      .| .||.|.. . .|| |  ..    .| |||..
eWPdkGvpkht..ssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvaha..kttrmvdvfnfvtnirqkrpylvqtqeqyafiyga
subfamily_PTPRN_pd Subfamily PTPRN 9-203 9.4e-32 104.9 In-house 99-286 (297) alignment 
Range on Protein: 9-203
Range on HMM: 99-286/297.0
QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTITTKpDYTITALILTNNTTAppSTREISHYQFT
.  ||||| |. .|.||||||||| |.  ||..   ...       ||| . | . .   . . .. | .. || . .. | |  |    || .. . | 
apayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcd.dylvrsfylknlqts..etrtvtqfhfl

SWKEKTTPNVALfvGFVVASREVSKKYEQeKDAPVIVHCSDGQGFTGVFVALDIGVRSHEEsKTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQ
||.|...|  |    ..   | | | |   . .|..|||||| | |||....|. .          .|.    . ||. | |.. .   ..|...
swpeegvPasak..sllefrrkvnksyrG.rscpivvhcsdGaGrtGvyilidlvlnrllk.Gvkeidiaatlehlrdqrpglvktkdqfefalt
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 9-203 2.2e-30 100.5 In-house 90-273 (439) alignment 
Range on Protein: 9-203
Range on HMM: 90-273/439.0
QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKN-KeadypfYWPTTEsgTGKYGSMSVTTKTITTKPDYTITALILTNNTTAPPSTREISHYQF
.. ||||| | .||  |||..|.|  . .|||. .  .  |      |||. .     || ..| .      |.|.|  . . |.       | . ....
dklyiatqgpkkettddfwrlviekktvtivmltnlvesyk......ywpsda..evcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhy

TSWKEKTTPNVALFVGFVVasREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEesKTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQ
..| .|  |  | .|   .  | .    ..|.  ||.|||| | | ||  .|||| .          ||.  . | ||. |  .. .| .| |||.
iawpdknvpaqashvldfl..rainsandkeeygpvvvhcsagvGrtGtiialdialeqlk..lenkvdikgivkvlrkqrkqmvqalcqyvfiyn
0041856 (Phosphotyrosine protein) phosphatases II 9-203 5.6e-29 96.4 In-house 33-165 (182) alignment 
Range on Protein: 9-203
Range on HMM: 33-165/182.0
QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNddqknkeadYPFYWPTTEsgtgkygsmsvttktittkpdytitaliltnnttappsTREISHYQFT
..|.||||.|. .|.|||..|..| | ..||...          . |||. .                                      .|.. .|...
atrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......................................erlgiqylyl

SWKEKTTPNVALFVGFVVASREvskkyeqeKDAPVIVHCSDGQGFTGVFVALDIGVRSheesktSvVDLFEVAKRLRQARCGIISSLPHYNFIYQ
.|   ..|..  .. |. . .|        .. ||.|||| | | ||..||...  .       . |.|.|. | .|..|.|.. .. .| |...
pwpDhgvpdldelldfieevle........eggpvlVHCsaGvgRtgtlvaaylmkkl......g.vsleeavklvrsrRpgmvitpnqyfflql
0043147 (Phosphotyrosine protein) phosphatases II 9-203 5.6e-29 96.5 In-house 19-155 (172) alignment 
Range on Protein: 9-203
Range on HMM: 19-155/172.0
QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDqknkeadypfywpttesgtgkygsmsvttktittkpdytitaliltnNTTAPPSTREISHYQFT
 .|.|||| |.|.|.||||.|..| | .|||....                                                 ..... .|.. .|...
pdrfiatqgplrntladfwrmlkelgithivnltel...............................................lydpellerlgiqylyl

SWKEKTTPNVALFVGFVvasREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVrsheesktS-VvDLFEVAKRLRQARCGIISSLPHYNFIYQ
.|   ..|. .|.  |.   . . ... .... ||.|||| | | ||..||...            . .|.|. . .|..|.|.. .  .|.|.|.
pwpDhgvpllelllefl...efidellalspggpvlVHCsaGvgRtgtlvaaylml........lgl.sleeavalvrekRpgavqnpsqyrflyy
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 9-189 6.6e-23 75.9 In-house 89-261 (301) alignment 
Range on Protein: 9-189
Range on HMM: 89-261/301.0
QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTITTK-PDYTITALILTNNTTAPPSTREISHYQF
 .|.|||| |...|. ||| |.      .|||.    ...|     | |.. | . . |  ....|.  .   . ..   .  ...|   .|| . |||.
phrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqy

TSWKEKTTPNVALFVgfvVASREVSKKYEQekdaPVIVHCSDGQGFTGVFVALDIGVRSHEESKTsvVDLFEVAKRLRQARC
..| .. .|.    .       |. || |.    |..||||.| | .  |.. ..  |  |  .|  ..| |  |.||. | 
sewtdrgvPkshael...fdlmelvkksek....PivvhcsaGiGrsvafigteylareveadpt..ieltealkhlrehrw
subfamily_CG42327_pd Subfamily CG42327 9-117 2.7e-19 64.0 In-house 71-178 (319) alignment 
Range on Protein: 9-117
Range on HMM: 71-178/319.0
QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESG--TGKYGSMSVTTKTITTKPDYTITALILTNNTTAppSTREISHYQ
.  |||.| .. .. .|||..|||  |  || . | ...     . |.|| |..  |  || . || |   .|  | |..|.| .       .||..|| 
pnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdke..esrelthyw

FtSWKEKTTPN
.  | |   | 
y.kwleaevPa
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 9-204 2.8e-19 63.9 In-house 80-264 (281) alignment 
Range on Protein: 9-204
Range on HMM: 80-264/281.0
QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTITTKPDYTITALILTNNTtappSTREISHYQFT
.| || || | .|| ||||.|.|.  .  |||. .  . .      |.|       ..  .||. .  | .     | | |. .      || |.|. . 
krgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyeg....etrlithwlwk

SWKEKTTPNVALFVGfvvasrEVSKKYEqEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEeSKTSVVDLFEVAKRLRQ-ARCGIISSLPHYNFIYQV
 | .   |. .  .       .. .|    . .| ..||| | | .| ..|..| ..|   |. .. |. ..  .||   |.  . .| .| .|..|
ewpdwqvpessevml......kilrkir.arstppvihcsagvgrsgtlmaveialqsih.shftlpdikqivshlrvtgraasvqtlqqymliwkv
subfamily_ptpA1_pd Subfamily ptpA1 9-162 8.8e-19 62.5 In-house 88-251 (418) alignment 
Range on Protein: 9-162
Range on HMM: 88-251/418.0
QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTES---------GTGKYGSMSVTTKTITTKPDYTITALILtnNTTAPPST
 ...|.|| |. .|.||||.||||     |||.. . .|       |||             |   .|. ||    .   |.  | .  .    |    |
pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrni..rltfeget

REISHYQFTSWKEKTTPNVALFVG---FVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDI
|.|..||.  | ..  |. .  .    . .. |.       ... |.||||| | | || |..  |
rditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavi
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 9-204 1.9e-17 57.9 In-house 95-284 (305) alignment 
Range on Protein: 9-204
Range on HMM: 95-284/305.0
QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVT-----TKTITTKPDYTITALILTNNttaPPSTREIS
..|.|..| |. .|. .|| || .    .|||.    .        |||..     .  |  |      .| .   ..  || | || .      .  . 
ekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltys...gdqkmsvr

HYQFTSWKEKTTPNVALfvgfvvASREVSKKYEQEKdAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTsVVDLFEVAKRLRQARCGIISSLPHYNFIYQ
| |.| | ..  | . |      .| |.       |  |..|||| | | ||  ||..  .    | |  .  . |. | ||. |.  | .  .| ||..
hlqwtewpdrgvppckl......tslellsairgsk.vpivvhcsagigrtgtivaieyilekiaenkp.cppmpelvkalrdqrafsiqndvqylfihr

V
|
v
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 9-204 2.4e-12 41.2 In-house 87-282 (305) alignment 
Range on Protein: 9-204
Range on HMM: 87-282/305.0
QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYG--SMSVTTKT-------ITTKPDYTITALILTNNTtAPPST
 .|.| || |. .| |||| | ..     | |. . ..        |... .  . ..      .. |        .... . ..|. .|. .  .  ..
pkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlvieg.pgeka

REISHYQFTSWKEKTTPNVALFVGFVVASREVSKkyeqekdAPVIVHCSDGQGFTGVFVALDIGVRSHeESKTSVVDLFEVAKRLRQARCGIISSLPHYN
| ..|| .  | ..  |   | .  ...   .||        |..|||| | | ||  | |.  .     .   . |   . ...|. |   | .   | 
rkvthyhwidwpdrgvpaadlailellekarpsk.......gpivvhcsagigrtgsvvmleyildql.lagqiiedtdkilqkireqrnnsiqtdaqyl

FIYQV
|..||
fvhqv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 9-59 7.6e-12 39.6 In-house 103-153 (350) alignment 
Range on Protein: 9-59
Range on HMM: 103-153/350.0
QRRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTT
. .||||| |...|. ||.... . .   |.....|. .    .  ||.  
dfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqeg
0051429 (Phosphotyrosine protein) phosphatases II 10-204 1.6e-31 105.4 In-house 22-220 (272) alignment 
Range on Protein: 10-204
Range on HMM: 22-220/272.0
RRYIATQHPMRETMADFWQMvWETGSGHIVMVNDDQKNKEADYPFYWP----------TTESGTGKYGSMSVTTKTITTKPDYTITALILTNNTTAPPSt
.|......|.. | ||||.. .| |  .||.. ..   .  ....|||           ..  |  || ..||.  .....||... |.||.  .|  . 
grlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagea.

REISHYQFTSWKEKTTPN--VALFVGFVVAsrevskkyeqekDAPVIVHCSDGQGFTGVFVALDIGVrsHEESKTSVVD--------LFEVAKRLRQARC
||. |...|.|    .|   .  .. .. .            . ||.|||| | . ||..|||.. .  .  |.. .||        |.|. ..||..| 
revmhlhytdwpdhgvpqeallellellld............ggpvlvHCsaGkdRTGtvvalllll..lgvsletivddYlltnlyleeaveelraqrp

GIISSLPHYNFIYQV
|.. .  .| |.|..
gavqteeqylflyea
0036282 (Phosphotyrosine protein) phosphatases II 10-203 7.4e-29 96.0 In-house 17-164 (174) alignment 
Range on Protein: 10-203
Range on HMM: 17-164/174.0
RRYIATQHPMRetmadFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTtesgtgkygsmsvttktittkpdytitaliltnntTAPPSTREISHYQFTS
.|.||.|.|..     ||.|..| |. ..||... . ..    . |||.                                   .    .|.. .|... 
prliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................lredlerlgiqylylp

WKEKTTPNVALFVGFVVASREVSKKyeqEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEeskTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQ
|   ..|... .  || . .|. ..    .. ||.|||| | | ||..||...  | ..   .|.|| ... ..||. |.|.. .  .| |.|.
wpDhgvpdlsillefvkfveealse...dpggpvlVHCsaGvgRtGtlvaaylmlrgll...eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 10-203 7.6e-17 56.3 In-house 82-271 (307) alignment 
Range on Protein: 10-203
Range on HMM: 82-271/307.0
RRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTK--TI---TTKPDYTITALiLTNNTTAPPSTREISH
...|..| |. .|. .|| |. .     ..|. .  .  .     |||  |  .  .|. . |     .   .  ||  .  .  | .      .| |.|
kkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinv.ttlkvdwaqksrtiqh

YQFTSWKEKTTPNVALFVGFVVASrevsKKYEQekdAPVIVHCSDGQGFTGVFVALDIgVRSHEESKTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQ
.|.. | .. .|.. |    .. .     .|..    ||.|||| | | .|  ||. . |.    .     |. .. . ||. |   | .   | ....
lqwenwpdrgvpqinltainllea....vrydt...npvvvhcsaGvGrsGtivaisl.vqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhr
subfamily_eak_pd Subfamily eak 10-131 7.9e-16 52.4 In-house 93-210 (332) alignment 
Range on Protein: 10-131
Range on HMM: 93-210/332.0
RRYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTITTKPDYTITALILTNNTtappSTREISHYQFTS
|.|| |  .  . .  ||||| |  |  ||.. .| ..|   .  |.|       |.| . |..|    .  .    |.|.        | .. ||..  
rkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGn....ethrvlhykvfG

WKEKTTPNVALFVGFVVASREV
| | |.| .  |. .  . .||
wtettlpkyedflalrkvmkev
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 10-201 1.2e-14 48.8 In-house 82-268 (312) alignment 
Range on Protein: 10-201
Range on HMM: 82-268/312.0
RRYIATQHPMRETMADFWQMVWETGSGHIVMVN---DDQKNKEADYPFYW-PTTESGTGKYGSMSVTTKTITTKPDYTITALILTNNTTAPPSTREISHY
 |...|| |. .| . |||..   ||  |...    .|  .| | |        .    .  . ..|   |  |    ||  .|     |      . ||
erfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhy

QFTSWKEKTTPNVAlfvgfVVASREVSKKYEQEKdaPVIVHCSDGQGFTGVFVALDIGVRSH-EESKTSVVDLFEVakrLRQARCGIISSLPHYNFI
|..|| ..  |.         | | .|    . |  ||| ||| | | || .. ..  . .     |  | | | .   ||. |.  .  .|.| . 
qwaswpdhgmpdsc.....dtalrllsavkkdkk..pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvl...lrkdrarsvrvfpqyvya
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 10-74 2.2e-06 21.3 In-house 236-296 (440) alignment 
Range on Protein: 10-74
Range on HMM: 236-296/440.0
RRYIATQHPMRETMADFWQMVWETGSGHIVMVNddQKNKEaDYPFYWPTTESgTGKYGSMSVTTK
  .|||| |.  |. |||..| .     |.|.|  | |       |||     .  .| ..|  |
nafiatqmpldstvldfwrlvhdyristiimln..qlndk.tcsiywpvntr.svtfgpftvghk
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 10-117 4.4e-06 21.0 In-house 28-129 (130) alignment 
Range on Protein: 10-117
Range on HMM: 28-129/130.0
RRYIATQHPMRETMADFWQMVWETGSGHIVMVNDdqKNKEADypfYWPTTESgTGKYGSMSVTTKTITTKPDYtITALILTNNTTAPPSTREISHYQFTS
. |. ||||. .|  |||.|. |     .|..     ..| .   ||| .|     |    . | |   . .. | |  |  .     | . .. .| . 
aeylltqhpladtsmdfwkmmleryvnvlvvlgs..veeede...ywpdseP.lewyeediivtltdrdefkn.ikasnleiesdlneshqaltmfqisn

WKE-KTTPN
|    ||||
wpsdgttpn
subfamily_PTPN23_pd Subfamily PTPN23 11-203 1.2e-37 124.3 In-house 84-274 (288) alignment 
Range on Protein: 11-203
Range on HMM: 84-274/288.0
RYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTITTKPDYTITALILTNNTTapPSTREISHYQFTSW
 .|||| |...|..|||.||.|  |  |||. . .. ..     |||. .  | |.| .||| |  .. . .    |.|. . .    ....|| |.|||
dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletlda..davksvshlqltsW

KEKTTPN-VALFVGFVVASREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHeESKTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQ
 |   |.    .. |. . ..  .. ... ..|..|||| | | ||||  .   ||   | .  ..|. .| .|||. |   ..   ...| |.
pelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrel.ekgnglldiiqvvsrlreqRrfmvqekeqlkfsye
0046846 (Phosphotyrosine protein) phosphatases II 11-203 1.2e-27 92.2 In-house 24-167 (176) alignment 
Range on Protein: 11-203
Range on HMM: 24-167/176.0
RYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGkygsmsvttktittkpdytitaliltnnttappstreisHYQFTSW
|.||||.|...|.|||..|..| | ...|......  .  . | |||  |.                                          .|... |
rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................................qylhlpw

KEKTTPNVALFVGFVVASREVSKKYeqekdAPVIVHCSDGQGFTGVFVALDIGVRsheeskTSVVDLFEVAKRLRQARC-GIISSLPHYNFIYQ
 . ..|. .|.  .. . ||. |.       ||.|||| | | ||..||...  .         ....|. ...|. |. |.. .  .| |.|.
pDhgvpdlelllellefirealkeg.....gpvlVHCsaGigRtgtlvaayllel......ekglsveealalvreqRplgavqtpeQyrflye
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 11-193 5.8e-24 79.2 In-house 95-267 (290) alignment 
Range on Protein: 11-193
Range on HMM: 95-267/290.0
RYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTiTTKPDYTITALILTNNTTAPPSTREISHYQFTSW
 .| || ....|. |.|.|| ...   |||. .  ..  |    |.| .|  .  .|...|.     ...|  |   .|.           . |..  ||
mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcse.eddkdaniikktlsvrdkdsGkehklkhlkiksw

KEKTTPNVALFVGFVVasREVskkyeQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTsvVDLFEVAKRLRQARCGIIS
 .|. .. .| .  ..  | .     ..   ||.|||| | | || |||...|..   . |   .|| .. . ||..| . . 
pdksvalstlallrtl..ril.....rkasGpvvvhcsaGiGrtGtfvaievglqilldGke..ldlldlvralrnsrlnsvq
0051082 (Phosphotyrosine protein) phosphatases II 11-203 4.4e-22 73.7 In-house 14-147 (151) alignment 
Range on Protein: 11-203
Range on HMM: 14-147/151.0
RYIATQHPmretMADFWQMVWETGSGHIVMVNDDQKNKeaDYPFYWPTTEsgtgkygsmsvttktittkpdytitaliltnnttappstREISHYQFTSW
.......|    .|||.....| |  .||...... ..   .| |.| ..                                       .|. |.....|
glyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.......................................ievlhipildw

KEKTTPNV----ALFVGFVVAsrevskkyeqEKDAPVIVHCSDGQGFTGVFVALDIGVRSheesktsvVDLFEVAKRLRQARCGIISSLPHYNFIYQ
.. ..|      . |. .. .           |. ||.|||| | | ||..|||..  .         |.|.|. . .|. |.|.. .  .. |...
pdpglplsfdavleflellld..........kkngpvlvHCsaGkgRTGtlvalylmllg........vsleealeeyrlkrpgvvqpnqqflfqlf
subfamily_egg_pd Subfamily egg 11-204 1.9e-21 71.1 In-house 84-265 (307) alignment 
Range on Protein: 11-204
Range on HMM: 84-265/307.0
RYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEAdyPFYWPTTESGTGKY--GSMSVTTKTITTKPD--YTITALILTNNTtappstREISHYQ
 .| .| |...|. |||.||..    .|||..  .....   ..||| .|| . ..  ||. ...  .  |.|  ...| | |          .|  . .
efilaqaplkntvddfwrmvfqeevqyivmltsrkeserc..eyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd......deerfle

FTSWKEKTTPNVALFVGFVVASREVSKkyeqekdaPVIVHCSDGQGFTGVFVALDIGVRSHEESKTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQV
   .  . . .|   .  .   |..||        ||.|.. .|   ....||..| . |     .    . .  . ||. |   ..|   | |.|..
hwqgdvnnssdvysplrvlrklrnlsk........pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 11-203 5e-13 43.1 In-house 91-279 (302) alignment 
Range on Protein: 11-203
Range on HMM: 91-279/302.0
RYIATQHPMRETM---ADFWQMVWETGSGHIVMVNDDQKNKEaDYPFYWPTTESGTGKYGSMSVTTKTITTKPDYT--ITALILTNNTTAPPsTREIshY
  | .| | ...    ..||.||..    ..|..  ... |.     ..|..     .||.| | .. .  . . .   .  .| .. .  .   ..  |
siilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsv.lanv..y

QFTSWKEKTTPnvALFVGFVVASREVsKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESktSVVDLFEVAKRLRQARCGIISSLPHYNFIYQ
 .| ||.|. |    .   . .  .|  . ... |.....    | |  |.|..| . | . ...  . .   |..| .|. |. .. ||  |...| 
vltnWkqkkvp..vkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkg..kepnikeivksiRsqRpravdslkQyvslyi
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 11-197 9.1e-13 42.4 In-house 95-278 (310) alignment 
Range on Protein: 11-197
Range on HMM: 95-278/310.0
RYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTeSGTGKYGSMSVTTKTItTKPDYTITALILTNNTTAPPSTR--------EI
 .| .| |.. |. |||.|...  .  |...    ..       |||.    |  || . ||  .  .  .. |  | .|      |            .
tficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl.gvtetygcirvtnlse.sseefeicnlavtfvpdnvpvdeqpanlkelrv

SHYQFTSWKEKTTPNVAlfvGFVVASREVSkkyeQEKDAPVIVHCSDGQGFTGVFVALDIGVRshEESKTSVVDLFEVAKRLRQARCGIISSLPH
|  ..  | ..  |.        |  | ..    | .  |..|||| |.. ..| |||.. .      .   ||. ||   |.. |   | .   
slikwpnwpdrgvpdek...chtvpqrlla....qvrhgpcvvhcsagkdrlyvvvalklkid..kldrglkvdaeevktellksraiciqtelq
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 11-118 1.8e-07 25.0 In-house 138-239 (244) alignment 
Range on Protein: 11-118
Range on HMM: 138-239/244.0
RYIATQHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEadypfYWPTTESGTgKYGsMSVtTKTITTKPDY-TITALILTNNTTAPPSTREISHYQFTS
 || ||||. .|  |||.|. |     .|..   ... |     ||| .|     |    . | |.| . ..  | |  |  ..    | . .. .| . 
eyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpdseple.wye.edi.tvtltdrdefknikasnleiesdmneshqaltmfqisn

WK-EKTTPNV
|  . |||| 
wpsdgttpnd
0044763 (Phosphotyrosine protein) phosphatases II 12-203 6.8e-20 66.9 In-house 31-165 (178) alignment 
Range on Protein: 12-203
Range on HMM: 31-165/178.0
YIATQHPmretmADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESgtgkygsmsvttktittkpdytitaliltnnttappstreiSHYQFTSWK
|.... |     ||......| | .|||...... .   ... |||. ..                                          .|... . 
ylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.........................................iqylhipip

EKTTPN-VALFVGFVVASREVSkkyeQEKDAPVIVHCSDGQGFTGVFVALDIGVRSheesktSVvDLFEVAKRLRQARCgIISSLPHYNFIYQ
  ..|.  . |  || . .|.     .||. ||.|||| | | .|..||...  .       .. .|.|. ...|..|. |. .  .....|.
Dhgvpdllehflefvefieeal....dekggpvlVHCsaGvgRsgtlvaaylmkkl......gl.sleeaielvrerRp.ivpnpgqlrqLye
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 14-193 3.5e-19 63.9 In-house 39-205 (255) alignment 
Range on Protein: 14-193
Range on HMM: 39-205/255.0
AtqhpmreTMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTitTKPDYTITALILTNNTTAPPSTREISHYQFTSWKEK
        |.. |.|..  |..  .||. | . ..  .   |.|.   .  |.  ..|||    .  |  . .| .| . .    |... ||... | ||
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWiek

TTPNVALFVGFVVASREVSKkyeqekdaPVIVHCSDGQGFTGVFVALDIG----VRSHEESKTSVVDLFEVAKRLRQARCGIIS
 .|. |  . ...     ||        .|.|||| | | .  ||  ..     .|| ....|  .|  .. . ||. | . | 
naPelareilnilkvvrdsk........svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraih
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 16-202 1.3e-15 52.3 In-house 66-252 (290) alignment 
Range on Protein: 16-202
Range on HMM: 66-252/290.0
QHPMR-------ETMADFWQMVWETGSGHIVMVNDDQKNKEA-DYpF----YWPTTESGTGKYGSMSVTTKTITTKPDYTITALILTNNTTAPpstREIS
| |          |. .|| |. .  . ..||. . .....  .  |    | |... .  |.. ..|  |   .. |  .  |... .   .     . 
qsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantsl.faCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeee...ftvt

HYQFTSWKEKTTPNVALFVGFVVasrevsKKYEqEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTSVvDLFEVAKRLRQARCGIISSLPHYNFIY
|... .|..  ...  . .  ..      .| .  ...|||||| ||     .. |...|     |.. ||  | .| | ||. |   |.|   . |. 
HsllkgWnklnvqedtktllsli......qkvk.asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsv.kledvlkalrkqralaitsalelafvd
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 16-193 5.2e-14 46.4 In-house 97-272 (302) alignment 
Range on Protein: 16-193
Range on HMM: 97-272/302.0
QHPMRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTI-------TTKPDYTITALILTNNTTAPPSTREISHYQFT
  | ..|.  .| .. .   . .| . .  ...|  .  |. .   |. |.|  .|.|. .       | | .... .. ..|. .     . ..  .|.
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

SWKEKTTPNVALfvgfvvASREVSKKYEQEKdAPVIVHCSDGQGFTGVFVALDIGVRSHeeSKTSVVDLFEVAKRLRQARCGIIS
.| .. .|. |       .. .. |  |  |   |.|||| | | || .||.  |.     ||  | || .. . .|| | | . 
awpdhGapkeay......taldilkfcesyk.knvlvhcsaGvGrtGtlvaikyGiqlc..skkkvtdllsivlpvrqcryGavq
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 16-203 6.1e-06 19.1 In-house 121-303 (346) alignment 
Range on Protein: 16-203
Range on HMM: 121-303/346.0
QHPMRE---TMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYwPTTESGTGKYGSMSVTTKTIT--TKP-DYTITALILTNNTTAppsTREISHyqFTS
| |  |    . ||| |...     . ..  |.| |..   ..    . |    | | .  .       | .|||  |   |  .      .. |   . 
qlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslf.ndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsv...icqvhh..hap

WKEKTTPNVALFVGFVVAsREVSKKyeQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESktSVVDLFEVAKRLRQARCGIISSLPHYNFIYQ
||    |  .| .  ..  .  |.|  | ..| | |    | | .  |.     ..  ..      ...|. | ..| | | . |.. |  || 
wkhlqqppktlpiikmih.qflsek..qvqnagvcvvslfgcgracsfigalyainqlnng..iepniceimknikqqrpggvesfaqyasiya
subfamily_hpo-7_pd Subfamily hpo-7 19-192 9.9e-16 52.4 In-house 43-210 (263) alignment 
Range on Protein: 19-192
Range on HMM: 43-210/263.0
MRETMADFWQMVWETGSGHIVMVNDDQKNKEADYPFYWPTTESGTGKYGSMSVTTKTITTkpDYTITALILTNNTTAPPSTREISHYQFTSWKEKTTPNV
. .|.. |.|..  |..  .||. | . .   .   |.|.   .  |.  ..|.|  .    |  . .| |...      |... ||... | ||  |. 
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

ALFVGFVVASREVSKkyeqekdaPVIVHCSDGQGFTGVFVALDIG----VRSHEESKTSVVDLFEVAKRLRQARCGII
|  .  ..     ||        ...|||| | | .  |.  ..     .|| ....|  .|  .. . ||. | . |
areilnilkvarnsk........slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkrai
0048076 (Phosphotyrosine protein) phosphatases II 55-203 7e-15 50.4 In-house 2-137 (145) alignment 
Range on Protein: 55-203
Range on HMM: 2-137/145.0
YWPTTESGTGKYGSMSvTTKTITTKPDYTITALILTnNTTAPPSTREISHYQFTSWKEKTTPNV-ALFVGFVVASREVSKKyeqekDAPVIVHCSDGQGF
|||.   .   .||.  |.. . .  |. ||...    .. .  .|.. .|....|   ..|.  .|.  |. . .|. |.     . ||.|||| | | 
ywpseilpglylgslp.taldlellkdlgittvlnl.tselellerlgiqylylpwpDhgvpdllellleflefieealke.....ggpvlVHCsaGvgR

TGVFVALDIGVRsheeskTSvVDLFEVAKRLRQARCGIISSLPHYNFIYQ
||..||...  .       . |.|.|. ...|..| |.. .  ...|.|.
tgtlvaaylmll......lg.vsleealelvrsqrpgavpnpgqlrflye
0048179 (Phosphotyrosine protein) phosphatases II 67-203 3.4e-14 48.3 In-house 14-139 (144) alignment 
Range on Protein: 67-203
Range on HMM: 14-139/144.0
GSMSvTTKTITTKPDYTITALI-LTNNTTAPPSTREISHYQFTSWKEKTTPNV-ALFVGFVVASREVskkyeQEKDAPVIVHCSDGQGFTGVFVALDIGV
||.  |.. . .  .. ||..| ||..   .  .||. .|....|    .|.  .|.  |. . .|.     .|.. ||.|||| | | ||..||... .
gslp.taldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieea.....leeggpvlVHCsaGvgRtgtlvaaylmk

rsheesKTSvVDLFEVAKRLRQARCGIISSLPHYNFIYQ
      |   ..|.|. ...|..|.|.. .  ...|...
......klg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 99-203 1.2e-11 38.6 In-house 88-188 (440) alignment 
Range on Protein: 99-203
Range on HMM: 88-188/440.0
TREISHYQFTSWKEKTTPNVALFVGFVVasREVSKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRshEESKTSVVDLFEVAKRLRQARCGIISSLPHY
.| . .|.. .| .|  |..|  |  ..  ..|..  |.  ..|..|||| | | ||| .|.|  .|  |  ..  .|.| . . .|. |  .. .  .|
srtlkqyhyqgwpdkgvpkfagpvlkmi..qdvnesqekagngpllvhcsagagrtgviiavdsilr..eakrsdqidifsfinsmrnnrpqmvqtpeqy

NFIYQ
 |...
afvhe
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 99-165 1.8e-08 28.5 In-house 214-287 (350) alignment 
Range on Protein: 99-165
Range on HMM: 214-287/350.0
TREISHYQFTSWKEK-TTPNVALFVGFV-----VASREVSK-KYEQEKDAPVIVHCSDGQGFTGVFVALDIGVR
  .. . |.  ||.  .  |   ..  .     .    ...  ..... .|..|||| | | ||..|.||  . 
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDslls
PTPc_DSPc_SM00012 102-204 3.9e-22 73.8 In-house 2-102 (105) alignment 
Range on Protein: 102-204
Range on HMM: 2-102/105.0
ISHYQFTSWKEKTTPNVAlfVGFVVASREVSKKYEQEK-DAPVIVHCSDGQGFTGVFVALDIGVRSHEESKtSVVDLFEVAKRLRQARCGIISSLPHYNF
..||..|.|... .|. .    .. . |.| |......  .||.||||.| | ||.|||||| ....|... . ||.|.. |.||. | | ....  | |
vkhyhytgwpdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket.kevdifqivkelrkqRpgmvqteeqylf

IYQV
.|..
lyra
subfamily_CG42327_pd Subfamily CG42327 132-204 2.2e-16 54.4 In-house 239-310 (319) alignment 
Range on Protein: 132-204
Range on HMM: 239-310/319.0
SKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEESKTSvVDLFEVAKRLRQARCGIISSLPHYNFIYQV
|.  ..|.  |..|||||| | ||. .| || .|| |||| | ||. ..   .|. |.  . .   |.|||.|
srsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrs.vdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 132-170 1.3e-06 22.0 In-house 257-295 (349) alignment 
Range on Protein: 132-170
Range on HMM: 257-295/349.0
SKKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVRSHEES
 . ..... ....|||| | | |||.| ||. .   |  
rlyldtdqlstllvhcsaGcGrtGvlvtldlllsilepl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 133-203 3.2e-07 24.5 In-house 221-289 (297) alignment 
Range on Protein: 133-203
Range on HMM: 221-289/297.0
KKYEQEKDAPVIVHCSDGQGFTGVFVALDIGVrsHEESKTSVVDLFEVAKRLRQARCGIISSLPHYNFIYQ
 . |. ..|...|||| | | .|| |  |. .      |  . |   . . ||. |  .. .|  ....|.
lraemprnayllvhcsaGvGrsGvvvlsdvil..aklrkkripdvaailsilreqrarlvqtleqfellyd
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 144-202 4.2e-06 21.1 In-house 2-58 (69) alignment 
Range on Protein: 144-202
Range on HMM: 2-58/69.0
IVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGIISSLPHYNFIY
.|||| | | || |.|. . .      |  .||.|.  . .|. |  ..     | ||.
vvhcssgtgrtgtfiaimvemariksek..lvdifnnvqymrkcrpmmvmneieyifih
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 144-202 6.4e-06 20.4 In-house 1-57 (69) alignment 
Range on Protein: 144-202
Range on HMM: 1-57/69.0
IVHCSDGQGFTGVFVALDIGVRSHEESKtsVVDLFEVAKRLRQARCGIISSLPHYNFIY
.|||| | | || |.|. . .      |  .||.|.  . .|. |  ..     | ||.
vvhcssGtGrtGtfiaimvemariksek..lvdifnnvqymrkcrpmmvmneneymfih